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Conserved domains on  [gi|547299573|ref|WP_022031970|]
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MULTISPECIES: threonine/serine exporter family protein [Hungatella]

Protein Classification

threonine/serine exporter family protein( domain architecture ID 10581889)

threonine/serine exporter family protein similar to ThrE, a membrane protein involved in the export of threonine and serine

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ThrE_2 pfam12821
Threonine/Serine exporter, ThrE; ThrE_2 is a family of membrane proteins involved in the ...
 4-131 2.26e-33

Threonine/Serine exporter, ThrE; ThrE_2 is a family of membrane proteins involved in the export of threonine and serine. L-threonine, L-serine are both substrates for the exporter. The exporter exhibits nine-ten predicted transmembrane-spanning helices with long charged C and N termini and an amphipathic helix present within the N terminus. L-Threonine can be made by the amino acid-producing bacterium Corynebacterium glutamicum, but the potential for amino acid formation can be considerably improved by reducing its intracellular degradation into glycine and increasing its export by this exporter. Members of the family are found in Bacteria, Archaea, and the fungal kingdoms, and the family can exist either as a single long polypeptide chain or as two short polypeptides. All family members show an extended hydrophilic N-terminal domain with weak sequence similarity to portions of hydrolases (proteases, peptidases, and glycosidases); this suggests that since this region is cytoplasmic to the membrane it may be generating the transport substrate, so may imply that threonine may not be the primary substrate and the ThrE has a subsidiary function.


:

Pssm-ID: 432807  Cd Length: 129  Bit Score: 113.77  E-value: 2.26e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547299573    4 QTIGAFLAVLSFALILEVPARHILRAGFVGAVCWAIYLISLRYSDSVIASAFVSTLVVAFISHIFARRFKVPVTVFLVAG 83
Cdd:pfam12821   1 QLIFAFIATLGFGILFNVPKRALFYAGIGGAVGWLVYLLLMHFGSSIALASFLAALAIGLLSEIFARRLKAPVTVFLVPG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 547299573   84 ILPSVPGASIYRSVYYMIRNASDLSTYYLTETLQIAGAIAMAVFIMDS 131
Cdd:pfam12821  81 IIPLVPGGGAYNTMYYLVQGNYALAVSYGLETLFIAGAIALGLVLVSL 128
 
Name Accession Description Interval E-value
ThrE_2 pfam12821
Threonine/Serine exporter, ThrE; ThrE_2 is a family of membrane proteins involved in the ...
 4-131 2.26e-33

Threonine/Serine exporter, ThrE; ThrE_2 is a family of membrane proteins involved in the export of threonine and serine. L-threonine, L-serine are both substrates for the exporter. The exporter exhibits nine-ten predicted transmembrane-spanning helices with long charged C and N termini and an amphipathic helix present within the N terminus. L-Threonine can be made by the amino acid-producing bacterium Corynebacterium glutamicum, but the potential for amino acid formation can be considerably improved by reducing its intracellular degradation into glycine and increasing its export by this exporter. Members of the family are found in Bacteria, Archaea, and the fungal kingdoms, and the family can exist either as a single long polypeptide chain or as two short polypeptides. All family members show an extended hydrophilic N-terminal domain with weak sequence similarity to portions of hydrolases (proteases, peptidases, and glycosidases); this suggests that since this region is cytoplasmic to the membrane it may be generating the transport substrate, so may imply that threonine may not be the primary substrate and the ThrE has a subsidiary function.


Pssm-ID: 432807  Cd Length: 129  Bit Score: 113.77  E-value: 2.26e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547299573    4 QTIGAFLAVLSFALILEVPARHILRAGFVGAVCWAIYLISLRYSDSVIASAFVSTLVVAFISHIFARRFKVPVTVFLVAG 83
Cdd:pfam12821   1 QLIFAFIATLGFGILFNVPKRALFYAGIGGAVGWLVYLLLMHFGSSIALASFLAALAIGLLSEIFARRLKAPVTVFLVPG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 547299573   84 ILPSVPGASIYRSVYYMIRNASDLSTYYLTETLQIAGAIAMAVFIMDS 131
Cdd:pfam12821  81 IIPLVPGGGAYNTMYYLVQGNYALAVSYGLETLFIAGAIALGLVLVSL 128
YjjB COG3610
Uncharacterized membrane protein YjjB, DUF3815 family [Function unknown];
1-141 1.44e-32

Uncharacterized membrane protein YjjB, DUF3815 family [Function unknown];


Pssm-ID: 442828  Cd Length: 150  Bit Score: 112.21  E-value: 1.44e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547299573   1 MVVQTIGAFLAVLSFALILEVPARHILRAGFVGAVCWAIYLISLRYSDSVIASAFVSTLVVAFISHIFARRFKVPVTVFL 80
Cdd:COG3610    6 LLLQLLAAFVAAVGFAVLFNAPRRALLWAGLGGALGWLVYLLLLDLGLGPVLATFVAALVVGLLAELLARRLKAPATVFT 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 547299573  81 VAGILPSVPGASIYRSVYYMIRNASDLSTYYLTETLQIAGAIAMAVFIMDSLFRLGQKKQS 141
Cdd:COG3610   86 VPGIIPLVPGSGAYRAMYALVEGDYLAALSNGLEALLIAGALAAGLLLGSLLARPRRRKRR 146
 
Name Accession Description Interval E-value
ThrE_2 pfam12821
Threonine/Serine exporter, ThrE; ThrE_2 is a family of membrane proteins involved in the ...
 4-131 2.26e-33

Threonine/Serine exporter, ThrE; ThrE_2 is a family of membrane proteins involved in the export of threonine and serine. L-threonine, L-serine are both substrates for the exporter. The exporter exhibits nine-ten predicted transmembrane-spanning helices with long charged C and N termini and an amphipathic helix present within the N terminus. L-Threonine can be made by the amino acid-producing bacterium Corynebacterium glutamicum, but the potential for amino acid formation can be considerably improved by reducing its intracellular degradation into glycine and increasing its export by this exporter. Members of the family are found in Bacteria, Archaea, and the fungal kingdoms, and the family can exist either as a single long polypeptide chain or as two short polypeptides. All family members show an extended hydrophilic N-terminal domain with weak sequence similarity to portions of hydrolases (proteases, peptidases, and glycosidases); this suggests that since this region is cytoplasmic to the membrane it may be generating the transport substrate, so may imply that threonine may not be the primary substrate and the ThrE has a subsidiary function.


Pssm-ID: 432807  Cd Length: 129  Bit Score: 113.77  E-value: 2.26e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547299573    4 QTIGAFLAVLSFALILEVPARHILRAGFVGAVCWAIYLISLRYSDSVIASAFVSTLVVAFISHIFARRFKVPVTVFLVAG 83
Cdd:pfam12821   1 QLIFAFIATLGFGILFNVPKRALFYAGIGGAVGWLVYLLLMHFGSSIALASFLAALAIGLLSEIFARRLKAPVTVFLVPG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 547299573   84 ILPSVPGASIYRSVYYMIRNASDLSTYYLTETLQIAGAIAMAVFIMDS 131
Cdd:pfam12821  81 IIPLVPGGGAYNTMYYLVQGNYALAVSYGLETLFIAGAIALGLVLVSL 128
YjjB COG3610
Uncharacterized membrane protein YjjB, DUF3815 family [Function unknown];
1-141 1.44e-32

Uncharacterized membrane protein YjjB, DUF3815 family [Function unknown];


Pssm-ID: 442828  Cd Length: 150  Bit Score: 112.21  E-value: 1.44e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547299573   1 MVVQTIGAFLAVLSFALILEVPARHILRAGFVGAVCWAIYLISLRYSDSVIASAFVSTLVVAFISHIFARRFKVPVTVFL 80
Cdd:COG3610    6 LLLQLLAAFVAAVGFAVLFNAPRRALLWAGLGGALGWLVYLLLLDLGLGPVLATFVAALVVGLLAELLARRLKAPATVFT 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 547299573  81 VAGILPSVPGASIYRSVYYMIRNASDLSTYYLTETLQIAGAIAMAVFIMDSLFRLGQKKQS 141
Cdd:COG3610   86 VPGIIPLVPGSGAYRAMYALVEGDYLAALSNGLEALLIAGALAAGLLLGSLLARPRRRKRR 146
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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