|
Name |
Accession |
Description |
Interval |
E-value |
| AcrA |
COG0845 |
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ... |
40-367 |
4.88e-48 |
|
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];
Pssm-ID: 440606 [Multi-domain] Cd Length: 324 Bit Score: 165.50 E-value: 4.88e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 40 REMPVKINNDANITALNKATIEPTVSGQVATMAVKVGDEVKQGQVVAMLDTSTMQQQLNQLIQQLGEAQSSGgvqavpqe 119
Cdd:COG0845 6 GDVPETVEATGTVEARREVEVRARVSGRVEEVLVDEGDRVKKGQVLARLDPPDLQAALAQAQAQLAAAQAQL-------- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 120 ttivpgAVSAADVNRAREMMQNGIITEKEY---QTIVQRSQATVVTSgggyvstggmetagiQAAIAQLQTQIAQAQIVS 196
Cdd:COG0845 78 ------ELAKAELERYKALLKKGAVSQQELdqaKAALDQAQAALAAA---------------QAALEQARANLAYTTIRA 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 197 PINGRVAAIYNEDRKVAIEGRPFMLIQQNSPVVASLSIPQNFALKlaeptIKPSIKVYLKID---DKQIPGEITYIDTNA 273
Cdd:COG0845 137 PFDGVVGERNVEPGQLVSAGTPLFTIADLDPLEVEFDVPESDLAR-----LKVGQPVTVTLDagpGKTFEGKVTFIDPAV 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 274 PAGVPSVLVKATFLNADGLIQPGEFYTLVIESEAKAPVLAVPKEAVRENKDGKFVYVVTADNTVDVRVVETSETDDDYTA 353
Cdd:COG0845 212 DPATRTVRVRAELPNPDGLLRPGMFVRVRIVLGERENALLVPASAVVRDGGGAYVFVVDADGKVERRPVTLGRRDGDQVE 291
|
330
....*....|....
gi 546351234 354 IVNGLVKGERVITS 367
Cdd:COG0845 292 VLSGLKAGDRVVVS 305
|
|
| RND_mfp |
TIGR01730 |
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion ... |
32-377 |
1.30e-43 |
|
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273776 [Multi-domain] Cd Length: 322 Bit Score: 153.62 E-value: 1.30e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 32 VTTAEADMREMPVKINNDANITALNKATIEPTVSGQVATMAVKVGDEVKQGQVVAMLDTSTMQQQLNQLIQQLGEAQSsg 111
Cdd:TIGR01730 1 VTVATVESETLANTLTFPGSLEAVDEADLAAEVAGKITKISVREGQKVKKGQVLARLDDDDYQLALQAALAQLAAAEA-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 112 gvQAvpqettivpgAVSAADVNRAREMMQNGIITEKEY---QTIVQRSQATVvtsgggyvstggmetAGIQAAIAQLQTQ 188
Cdd:TIGR01730 79 --QL----------ELAQRSFERAERLVKRNAVSQADLddaKAAVEAAQADL---------------EAAKASLASAQLN 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 189 IAQAQIVSPINGRVAAIYNEDRKVAIEGRPFMLIQQNSPVVASLSIPQNFAlklaePTIKPSIKVYLKIDD---KQIPGE 265
Cdd:TIGR01730 132 LRYTEIRAPFDGTIGRRLVEVGAYVTAGQTLATIVDLDPLEADFSVPERDL-----PQLRRGQTLTVELDAlpgEEFKGK 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 266 ITYIDTNAPAGVPSVLVKATFLNADGLIQPGEFYTLVIESEAKAPVLAVPKEAVRENKDGKFVYVVTADNTVDVRVVETS 345
Cdd:TIGR01730 207 LRFIDPRVDSGTGTVRVRATFPNPDGRLLPGMFGRVTISLKVRSSAIVVPTQAVIEDLNGKYVYVVKNDGKVSKRPVEVG 286
|
330 340 350
....*....|....*....|....*....|....
gi 546351234 346 ETDDDYTAIVNGLVKGERVITSkGEFEL--GEKV 377
Cdd:TIGR01730 287 LRNGGYVEIESGLKAGDQIVTA-GVVKLrdGAKV 319
|
|
| PRK11556 |
PRK11556 |
MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit; |
20-366 |
7.79e-18 |
|
MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit;
Pssm-ID: 183194 [Multi-domain] Cd Length: 415 Bit Score: 84.46 E-value: 7.79e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 20 AGLMAGCFGPtkVTTAEADMREMPVKINNDANITALNKATIEPTVSGQVATMAVKVGDEVKQGQVVAMLDTSTMQQQLnq 99
Cdd:PRK11556 52 RGMRSGPLAP--VQAATATEQAVPRYLTGLGTVTAANTVTVRSRVDGQLMALHFQEGQQVKAGDLLAEIDPRPFKVAL-- 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 100 liqqlgeAQSSGgvQAVPQETTIvpgAVSAADVNRAREMMQNGIITEKEY---QTIVQRSQATVVTSgggyvstggmeta 176
Cdd:PRK11556 128 -------AQAQG--QLAKDQATL---ANARRDLARYQQLAKTNLVSRQELdaqQALVSETEGTIKAD------------- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 177 giQAAIAQLQTQIAQAQIVSPINGRVAAiynedRKVAI-------EGRPFMLIQQNSPVVASLSIPQN--FALKLAEPTI 247
Cdd:PRK11556 183 --EASVASAQLQLDYSRITAPISGRVGL-----KQVDVgnqissgDTTGIVVITQTHPIDLVFTLPESdiATVVQAQKAG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 248 KP-SIKVYLKIDDKQIP-GEITYIDTNAPAGVPSVLVKATFLNADGLIQPGEFYT--LVIESEAKAPVlaVPKEAVRENK 323
Cdd:PRK11556 256 KPlVVEAWDRTNSKKLSeGTLLSLDNQIDATTGTIKLKARFNNQDDALFPNQFVNarMLVDTLQNAVV--IPTAALQMGN 333
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 546351234 324 DGKFVYVVTADNTVDVRVVETSETDDDYTAIVNGLVKGERVIT 366
Cdd:PRK11556 334 EGHFVWVLNDENKVSKHLVTPGIQDSQKVVISAGLSAGDRVVT 376
|
|
| CusB_dom_1 |
pfam00529 |
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ... |
56-366 |
8.37e-07 |
|
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.
Pssm-ID: 425733 [Multi-domain] Cd Length: 322 Bit Score: 50.11 E-value: 8.37e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 56 NKATIEPTVSGQVATMAVKVGDEVKQGQVVAMLDTSTmqqqlnqliqqlgeaqssggvqavpqettivpgavSAADVNRA 135
Cdd:pfam00529 19 NAKAVQPQVSGIVTRVLVKEGDRVKAGDVLFQLDPTD-----------------------------------YQAALDSA 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 136 REMMQNGIITEKEYQTIVQRSQATVVTSGGGYVSTGGMETA--GIQAAIAQLQTQIAQAQI-------VSPINGRVAAIY 206
Cdd:pfam00529 64 EAQLAKAQAQVARLQAELDRLQALESELAISRQDYDGATAQlrAAQAAVKAAQAQLAQAQIdlarrrvLAPIGGISRESL 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 207 NEDRKVAIEGRPFML--IQQNSPVVASLSIPQNFALKL-------AEPTIKPSIKVYLKIDDKQ--------IPGEITYI 269
Cdd:pfam00529 144 VTAGALVAQAQANLLatVAQLDQIYVQITQSAAENQAEvrselsgAQLQIAEAEAELKLAKLDLerteirapVDGTVAFL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 270 DTNAPAGVPSVLVKATFLN-ADGLIQPGEF-YTLVIESEAKAPVLaVPKEAVRENKDGKF-VYVVTADNTVDVRVVETSE 346
Cdd:pfam00529 224 SVTVDGGTVSAGLRLMFVVpEDNLLVPGMFvETQLDQVRVGQPVL-IPFDAFPQTKTGRFtGVVVGISPDTGPVRVVVDK 302
|
330 340
....*....|....*....|
gi 546351234 347 TDDDYTAIVNGLVKGERVIT 366
Cdd:pfam00529 303 AQGPYYPLRIGLSAGALVRL 322
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| AcrA |
COG0845 |
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ... |
40-367 |
4.88e-48 |
|
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];
Pssm-ID: 440606 [Multi-domain] Cd Length: 324 Bit Score: 165.50 E-value: 4.88e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 40 REMPVKINNDANITALNKATIEPTVSGQVATMAVKVGDEVKQGQVVAMLDTSTMQQQLNQLIQQLGEAQSSGgvqavpqe 119
Cdd:COG0845 6 GDVPETVEATGTVEARREVEVRARVSGRVEEVLVDEGDRVKKGQVLARLDPPDLQAALAQAQAQLAAAQAQL-------- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 120 ttivpgAVSAADVNRAREMMQNGIITEKEY---QTIVQRSQATVVTSgggyvstggmetagiQAAIAQLQTQIAQAQIVS 196
Cdd:COG0845 78 ------ELAKAELERYKALLKKGAVSQQELdqaKAALDQAQAALAAA---------------QAALEQARANLAYTTIRA 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 197 PINGRVAAIYNEDRKVAIEGRPFMLIQQNSPVVASLSIPQNFALKlaeptIKPSIKVYLKID---DKQIPGEITYIDTNA 273
Cdd:COG0845 137 PFDGVVGERNVEPGQLVSAGTPLFTIADLDPLEVEFDVPESDLAR-----LKVGQPVTVTLDagpGKTFEGKVTFIDPAV 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 274 PAGVPSVLVKATFLNADGLIQPGEFYTLVIESEAKAPVLAVPKEAVRENKDGKFVYVVTADNTVDVRVVETSETDDDYTA 353
Cdd:COG0845 212 DPATRTVRVRAELPNPDGLLRPGMFVRVRIVLGERENALLVPASAVVRDGGGAYVFVVDADGKVERRPVTLGRRDGDQVE 291
|
330
....*....|....
gi 546351234 354 IVNGLVKGERVITS 367
Cdd:COG0845 292 VLSGLKAGDRVVVS 305
|
|
| RND_mfp |
TIGR01730 |
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion ... |
32-377 |
1.30e-43 |
|
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273776 [Multi-domain] Cd Length: 322 Bit Score: 153.62 E-value: 1.30e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 32 VTTAEADMREMPVKINNDANITALNKATIEPTVSGQVATMAVKVGDEVKQGQVVAMLDTSTMQQQLNQLIQQLGEAQSsg 111
Cdd:TIGR01730 1 VTVATVESETLANTLTFPGSLEAVDEADLAAEVAGKITKISVREGQKVKKGQVLARLDDDDYQLALQAALAQLAAAEA-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 112 gvQAvpqettivpgAVSAADVNRAREMMQNGIITEKEY---QTIVQRSQATVvtsgggyvstggmetAGIQAAIAQLQTQ 188
Cdd:TIGR01730 79 --QL----------ELAQRSFERAERLVKRNAVSQADLddaKAAVEAAQADL---------------EAAKASLASAQLN 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 189 IAQAQIVSPINGRVAAIYNEDRKVAIEGRPFMLIQQNSPVVASLSIPQNFAlklaePTIKPSIKVYLKIDD---KQIPGE 265
Cdd:TIGR01730 132 LRYTEIRAPFDGTIGRRLVEVGAYVTAGQTLATIVDLDPLEADFSVPERDL-----PQLRRGQTLTVELDAlpgEEFKGK 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 266 ITYIDTNAPAGVPSVLVKATFLNADGLIQPGEFYTLVIESEAKAPVLAVPKEAVRENKDGKFVYVVTADNTVDVRVVETS 345
Cdd:TIGR01730 207 LRFIDPRVDSGTGTVRVRATFPNPDGRLLPGMFGRVTISLKVRSSAIVVPTQAVIEDLNGKYVYVVKNDGKVSKRPVEVG 286
|
330 340 350
....*....|....*....|....*....|....
gi 546351234 346 ETDDDYTAIVNGLVKGERVITSkGEFEL--GEKV 377
Cdd:TIGR01730 287 LRNGGYVEIESGLKAGDQIVTA-GVVKLrdGAKV 319
|
|
| PRK11556 |
PRK11556 |
MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit; |
20-366 |
7.79e-18 |
|
MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit;
Pssm-ID: 183194 [Multi-domain] Cd Length: 415 Bit Score: 84.46 E-value: 7.79e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 20 AGLMAGCFGPtkVTTAEADMREMPVKINNDANITALNKATIEPTVSGQVATMAVKVGDEVKQGQVVAMLDTSTMQQQLnq 99
Cdd:PRK11556 52 RGMRSGPLAP--VQAATATEQAVPRYLTGLGTVTAANTVTVRSRVDGQLMALHFQEGQQVKAGDLLAEIDPRPFKVAL-- 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 100 liqqlgeAQSSGgvQAVPQETTIvpgAVSAADVNRAREMMQNGIITEKEY---QTIVQRSQATVVTSgggyvstggmeta 176
Cdd:PRK11556 128 -------AQAQG--QLAKDQATL---ANARRDLARYQQLAKTNLVSRQELdaqQALVSETEGTIKAD------------- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 177 giQAAIAQLQTQIAQAQIVSPINGRVAAiynedRKVAI-------EGRPFMLIQQNSPVVASLSIPQN--FALKLAEPTI 247
Cdd:PRK11556 183 --EASVASAQLQLDYSRITAPISGRVGL-----KQVDVgnqissgDTTGIVVITQTHPIDLVFTLPESdiATVVQAQKAG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 248 KP-SIKVYLKIDDKQIP-GEITYIDTNAPAGVPSVLVKATFLNADGLIQPGEFYT--LVIESEAKAPVlaVPKEAVRENK 323
Cdd:PRK11556 256 KPlVVEAWDRTNSKKLSeGTLLSLDNQIDATTGTIKLKARFNNQDDALFPNQFVNarMLVDTLQNAVV--IPTAALQMGN 333
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 546351234 324 DGKFVYVVTADNTVDVRVVETSETDDDYTAIVNGLVKGERVIT 366
Cdd:PRK11556 334 EGHFVWVLNDENKVSKHLVTPGIQDSQKVVISAGLSAGDRVVT 376
|
|
| EmrA |
COG1566 |
Multidrug resistance efflux pump EmrA [Defense mechanisms]; |
6-296 |
2.59e-15 |
|
Multidrug resistance efflux pump EmrA [Defense mechanisms];
Pssm-ID: 441174 [Multi-domain] Cd Length: 331 Bit Score: 76.24 E-value: 2.59e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 6 RRFRWLFMVMIVMVAGLM---AGCFGPTKVTTAeadmrempvkinnDANITAlNKATIEPTVSGQVATMAVKVGDEVKQG 82
Cdd:COG1566 5 KKRRLLALVLLLLALGLAlwaAGRNGPDEPVTA-------------DGRVEA-RVVTVAAKVSGRVTEVLVKEGDRVKKG 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 83 QVVAMLDTSTMQQQLNQLIQQLGEAQSS----GGVQAVPQETTIVPGAVSAA---------DVNRAREMMQNGIITEKEY 149
Cdd:COG1566 71 QVLARLDPTDLQAALAQAEAQLAAAEAQlarlEAELGAEAEIAAAEAQLAAAqaqldlaqrELERYQALYKKGAVSQQEL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 150 QTI----------VQRSQATVVTSGGGYVSTGGMETAgiQAAIAQLQTQIAQAQ-------IVSPINGRVAAIYNEDRKV 212
Cdd:COG1566 151 DEAraaldaaqaqLEAAQAQLAQAQAGLREEEELAAA--QAQVAQAEAALAQAElnlarttIRAPVDGVVTNLNVEPGEV 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 213 AIEGRPFMLIQQNSPVVASLSIPQNFALKlaeptIKPSIKVYLKID---DKQIPGEITYI----------DTNAPAGVPS 279
Cdd:COG1566 229 VSAGQPLLTIVPLDDLWVEAYVPETDLGR-----VKPGQPVEVRVDaypDRVFEGKVTSIspgagftsppKNATGNVVQR 303
|
330
....*....|....*...
gi 546351234 280 VLVKATFLNADGL-IQPG 296
Cdd:COG1566 304 YPVRIRLDNPDPEpLRPG 321
|
|
| PRK15030 |
PRK15030 |
multidrug efflux RND transporter periplasmic adaptor subunit AcrA; |
39-367 |
4.00e-13 |
|
multidrug efflux RND transporter periplasmic adaptor subunit AcrA;
Pssm-ID: 184990 [Multi-domain] Cd Length: 397 Bit Score: 70.13 E-value: 4.00e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 39 MREMPVKINND--ANITALNKATIEPTVSGQVATMAVKVGDEVKQGQVVAMLDTSTMQQQLNQLIQQLGEAQSSGGVQAV 116
Cdd:PRK15030 45 VKTEPLQITTElpGRTSAYRIAEVRPQVSGIILKRNFKEGSDIEAGVSLYQIDPATYQATYDSAKGDLAKAQAAANIAQL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 117 PqettivpgavsaadVNRAREMMQNGIITEKEY-QTIVQRSQATVVTSGGgyvstggmetagiQAAIAQLQTQIAQAQIV 195
Cdd:PRK15030 125 T--------------VNRYQKLLGTQYISKQEYdQALADAQQANAAVTAA-------------KAAVETARINLAYTKVT 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 196 SPINGRVAAIYNEDRKVAIEGRPFML--IQQNSPVVASLSIPQNFALKLAEPTIKPSIK-------VYLKIDDK-QIP-- 263
Cdd:PRK15030 178 SPISGRIGKSNVTEGALVQNGQATALatVQQLDPIYVDVTQSSNDFLRLKQELANGTLKqengkakVSLITSDGiKFPqd 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 264 GEITYIDTNAPAGVPSVLVKATFLNADGLIQPGEFYTLVIESEAKAPVLAVPKEAV-RENKDGKFVYVVTADNTVDVRVV 342
Cdd:PRK15030 258 GTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGLNPNAILVPQQGVtRTPRGDATVLVVGADDKVETRPI 337
|
330 340
....*....|....*....|....*
gi 546351234 343 ETSETDDDYTAIVNGLVKGERVITS 367
Cdd:PRK15030 338 VASQAIGDKWLVTEGLKAGDRVVIS 362
|
|
| PRK09859 |
PRK09859 |
multidrug transporter subunit MdtE; |
58-367 |
1.17e-12 |
|
multidrug transporter subunit MdtE;
Pssm-ID: 137559 [Multi-domain] Cd Length: 385 Bit Score: 68.59 E-value: 1.17e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 58 ATIEPTVSGQVATMAVKVGDEVKQGQVVAMLDTSTMQQQLNQLIQQLGEAQSSGgvqavpqettivpgAVSAADVNRARE 137
Cdd:PRK09859 62 AEIRPQVGGIIIKRNFIEGDKVNQGDSLYQIDPAPLQAELNSAKGSLAKALSTA--------------SNARITFNRQAS 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 138 MMQNGIITEKEYQTivQRSQatvvtsgggyVSTGGMETAGIQAAIAQLQTQIAQAQIVSPING-------RVAAIYNEDR 210
Cdd:PRK09859 128 LLKTNYVSRQDYDT--ARTQ----------LNEAEANVTVAKAAVEQATINLQYANVTSPITGvsgkssvTVGALVTANQ 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 211 KVAIegrpfMLIQQNSPVVASLSIPQNFALKLAEPT-------IKPSIKVYLKIDDKQ---IPGEITYIDTNAPAGVPSV 280
Cdd:PRK09859 196 ADSL-----VTVQRLDPIYVDLTQSVQDFLRMKEEVasgqikqVQGSTPVQLNLENGKrysQTGTLKFSDPTVDETTGSV 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 281 LVKATFLNADGLIQPGEFYTLVIESEAKAPVLAVPKEAVRENKDGKFV-YVVTADNTVDVRVVETSETDDDYTAIVNGLV 359
Cdd:PRK09859 271 TLRAIFPNPNGDLLPGMYVTALVDEGSRQNVLLVPQEGVTHNAQGKATaLILDKDDVVQLREIEASKAIGDQWVVTSGLQ 350
|
....*...
gi 546351234 360 KGERVITS 367
Cdd:PRK09859 351 AGDRVIVS 358
|
|
| PRK09578 |
PRK09578 |
MexX/AxyX family multidrug efflux RND transporter periplasmic adaptor subunit; |
3-367 |
3.98e-09 |
|
MexX/AxyX family multidrug efflux RND transporter periplasmic adaptor subunit;
Pssm-ID: 169982 [Multi-domain] Cd Length: 385 Bit Score: 57.88 E-value: 3.98e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 3 ERQRRFRWLFMVMIVMvaGLMAGCF---------GPTKVTTAEADMREMPVKINNDANITALNKATIEPTVSGQVATMAV 73
Cdd:PRK09578 2 EWARRRRLLLAALVAL--FVLAGCGkgdsdaaaaAPREATVVTVRPTSVPMTVELPGRLDAYRQAEVRARVAGIVTARTY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 74 KVGDEVKQGQVVAMLDTSTMQQQLNQLIQQLGEAQSSggvqavpqettivpgAVSAAD-VNRAREMMQNGIITEKEYQTI 152
Cdd:PRK09578 80 EEGQEVKQGAVLFRIDPAPLKAARDAAAGALAKAEAA---------------HLAALDkRRRYDDLVRDRAVSERDYTEA 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 153 V---QRSQATVVTSgggyvstggmetagiQAAIAQLQTQIAQAQIVSPINGRVA-AIYNEDRKVAI-EGRPFMLIQQNSP 227
Cdd:PRK09578 145 VadeRQAKAAVASA---------------KAELARAQLQLDYATVTAPIDGRARrALVTEGALVGQdQATPLTTVEQLDP 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 228 VVASLSIPQNFALKL--------AEPTIKPSIKVYLKIDDK---QIPGEITYIDTNAPAGVPSVLVKATFLNADGLIQPG 296
Cdd:PRK09578 210 IYVNFSQPAADVEALrravksgrATGIAQQDVAVTLVRADGseyPLKGKLLFSDLAVDPTTDTVAMRALFPNPERELLPG 289
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 546351234 297 EFYTLVIESEAKAPVLAVPKEAVRENKDGKFVYVVTADNTV-DVRVVETSETDDDYTaIVNGLVKGERVITS 367
Cdd:PRK09578 290 AYVRIALDRAVNPRAILVPRDALLRTADSASVKVVGQNGKVrDVEVEADQMSGRDWI-VTRGLAGGERVIVD 360
|
|
| CusB_dom_1 |
pfam00529 |
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ... |
56-366 |
8.37e-07 |
|
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.
Pssm-ID: 425733 [Multi-domain] Cd Length: 322 Bit Score: 50.11 E-value: 8.37e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 56 NKATIEPTVSGQVATMAVKVGDEVKQGQVVAMLDTSTmqqqlnqliqqlgeaqssggvqavpqettivpgavSAADVNRA 135
Cdd:pfam00529 19 NAKAVQPQVSGIVTRVLVKEGDRVKAGDVLFQLDPTD-----------------------------------YQAALDSA 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 136 REMMQNGIITEKEYQTIVQRSQATVVTSGGGYVSTGGMETA--GIQAAIAQLQTQIAQAQI-------VSPINGRVAAIY 206
Cdd:pfam00529 64 EAQLAKAQAQVARLQAELDRLQALESELAISRQDYDGATAQlrAAQAAVKAAQAQLAQAQIdlarrrvLAPIGGISRESL 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 207 NEDRKVAIEGRPFML--IQQNSPVVASLSIPQNFALKL-------AEPTIKPSIKVYLKIDDKQ--------IPGEITYI 269
Cdd:pfam00529 144 VTAGALVAQAQANLLatVAQLDQIYVQITQSAAENQAEvrselsgAQLQIAEAEAELKLAKLDLerteirapVDGTVAFL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 270 DTNAPAGVPSVLVKATFLN-ADGLIQPGEF-YTLVIESEAKAPVLaVPKEAVRENKDGKF-VYVVTADNTVDVRVVETSE 346
Cdd:pfam00529 224 SVTVDGGTVSAGLRLMFVVpEDNLLVPGMFvETQLDQVRVGQPVL-IPFDAFPQTKTGRFtGVVVGISPDTGPVRVVVDK 302
|
330 340
....*....|....*....|
gi 546351234 347 TDDDYTAIVNGLVKGERVIT 366
Cdd:pfam00529 303 AQGPYYPLRIGLSAGALVRL 322
|
|
| PRK09783 |
PRK09783 |
copper/silver efflux system membrane fusion protein CusB; Provisional |
172-367 |
4.20e-05 |
|
copper/silver efflux system membrane fusion protein CusB; Provisional
Pssm-ID: 236625 [Multi-domain] Cd Length: 409 Bit Score: 45.24 E-value: 4.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 172 GMETAGIQAAIA--QLQTQIAqaqIVSPINGRVAAI-------YNEDRKVAiegrpfmLIQQNSPVVASLSIPQNFALKL 242
Cdd:PRK09783 191 GMPEADIRRLIAtrKIQTRFT---LKAPIDGVITAFdlragmnIAKDNVVA-------KIQGMDPVWVTAAIPESIAWLV 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 243 AEPT-IKPSIKVYlkiDDKQIPGEITYIDTNAPAGVPSVLVKATFLNADGLIQPGEFYTLVIESEAkAPVLAVPKEAVRE 321
Cdd:PRK09783 261 KDASqFTLTVPAR---PDKTFTIRKWTLLPSVDAATRTLQLRLEVDNADEALKPGMNAWLQLNTAS-EPMLLIPSQALID 336
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 546351234 322 NKDGKFVYVVTADNTVDVRVVETSETDDDYTAIVNGLVKGERVITS 367
Cdd:PRK09783 337 TGSEQRVITVDADGRFVPKRVAVFQESQGVTAIRSGLAEGEKVVSS 382
|
|
| PRK11578 |
PRK11578 |
macrolide transporter subunit MacA; Provisional |
1-89 |
7.81e-04 |
|
macrolide transporter subunit MacA; Provisional
Pssm-ID: 183211 [Multi-domain] Cd Length: 370 Bit Score: 41.30 E-value: 7.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 1 MEERQRRFRWLFMVMIVMVAGLMAGCF--GP-TKVTTAEADMREMPVKINNDANITALNKATIEPTVSGQVATMAVKVGD 77
Cdd:PRK11578 2 KKRKKVKKRYLIALVIVLAGGITLWRIlnAPvPTYQTLIVRPGDLQQSVLATGKLDALRKVDVGAQVSGQLKTLSVAIGD 81
|
90
....*....|..
gi 546351234 78 EVKQGQVVAMLD 89
Cdd:PRK11578 82 KVKKDQLLGVID 93
|
|
| PRK10476 |
PRK10476 |
multidrug transporter subunit MdtN; |
48-222 |
1.19e-03 |
|
multidrug transporter subunit MdtN;
Pssm-ID: 182488 [Multi-domain] Cd Length: 346 Bit Score: 40.40 E-value: 1.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 48 NDANITAlNKATIEPTVSGQVATMAVKVGDEVKQGQVV-----------------------AMLDTSTMQQQLNQLIQQL 104
Cdd:PRK10476 40 DDAYIDA-DVVHVASEVGGRIVELAVTENQAVKKGDLLfridprpyeltvaqaqadlaladAQIMTTQRSVDAERSNAAS 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 105 GEAQSSGGVQAVPQETTIV--------PGAVSAADVNRAREMMQNGIITEKeyQTIVQRSQATVVTSGggyvsTGGMET- 175
Cdd:PRK10476 119 ANEQVERARANAKLATRTLerlepllaKGYVSAQQVDQARTAQRDAEVSLN--QALLQAQAAAAAVGG-----VDALVAq 191
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 546351234 176 -AGIQAAIAQLQTQIAQAQIVSPINGRVAAIYNEDRKVAIEGRP-FMLI 222
Cdd:PRK10476 192 rAAREAALAIAELHLEDTTVRAPFDGRVVGLKVSVGEFAAPMQPiFTLI 240
|
|
| Biotin_lipoyl_2 |
pfam13533 |
Biotin-lipoyl like; |
56-91 |
1.85e-03 |
|
Biotin-lipoyl like;
Pssm-ID: 433286 Cd Length: 50 Bit Score: 35.88 E-value: 1.85e-03
10 20 30
....*....|....*....|....*....|....*.
gi 546351234 56 NKATIEPTVSGQVATMAVKVGDEVKQGQVVAMLDTS 91
Cdd:pfam13533 1 PVVKIASPVSGKVVAVNVKEGQQVKKGDVLATLDSP 36
|
|
| PRK03598 |
PRK03598 |
putative efflux pump membrane fusion protein; Provisional |
64-193 |
3.37e-03 |
|
putative efflux pump membrane fusion protein; Provisional
Pssm-ID: 235136 [Multi-domain] Cd Length: 331 Bit Score: 39.17 E-value: 3.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 64 VSGQVATMAVKVGDEVKQGQVVAMLDTSTMQQQLNQLIQQLGEAQSS-----GGVQavPQETTIVPGAVSAADV------ 132
Cdd:PRK03598 50 VGGRLASLAVDEGDAVKAGQVLGELDAAPYENALMQAKANVSVAQAQldlmlAGYR--DEEIAQARAAVKQAQAaydyaq 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 546351234 133 ---NRAREMMQNGIITEKEY-QTIVQRSQAtvvtsgggyvstggmeTAGIQAA---------------IAQLQTQIAQAQ 193
Cdd:PRK03598 128 nfyNRQQGLWKSRTISANDLeNARSSRDQA----------------QATLKSAqdklsqyregnrpqdIAQAKASLAQAQ 191
|
|
| SHOCT_2 |
pfam20612 |
SHOCT domain; This family of proteins is functionally uncharacterized. This family of proteins ... |
135-152 |
5.37e-03 |
|
SHOCT domain; This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 53 and 72 amino acids in length. This family of proteins is related to the SHOCT domain.
Pssm-ID: 466761 Cd Length: 53 Bit Score: 34.83 E-value: 5.37e-03
|
| |
