|
Name |
Accession |
Description |
Interval |
E-value |
| AlaS |
COG0013 |
Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Alanyl-tRNA ... |
4-872 |
0e+00 |
|
Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Alanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439784 [Multi-domain] Cd Length: 880 Bit Score: 1313.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 4 MTSAEVRQMFLDFFKSKGHTVEPSQSLVPVNDPTLLWINSGVATLKKYFDGSVVPENPRLTNAQKAIRT----NDIENVG 79
Cdd:COG0013 2 MTSAEIRQKFLDFFESKGHTIVPSSSLVPKNDPTLLFTNAGMVQFKPYFLGQEKPPYPRATTSQKCVRTggkhNDLENVG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 80 KTARHHTMFEMLGNFSIGDYFRKEAIAFAWELLTssEWFEFPAEKLYITYYPADMDTYNRWV-EVGVDPTHLVPI--EDN 156
Cdd:COG0013 82 YTARHHTFFEMLGNFSFGDYFKEEAIAWAWELLT--EVLGLPKERLWVTVYEDDDEAYDIWKkEIGVPEERIIRLgkKDN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 157 FWEIGA-GPSGPDTEIFFDRGEVYDPEHVGLkllaEDIENDRYIEIWNIVLSQFNADPSiprSEYPELPQKNIDTGMGLE 235
Cdd:COG0013 160 FWEMGDtGPCGPCSEIFYDRGPEYGGGPPGS----PGEDGDRYIEIWNLVFMQFNRDED---GTLTPLPKKNIDTGMGLE 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 236 RMVCIIQGGKTNFDTDLFLPIIREIEKLSGKTYSPDSE-NMSFKVIADHIRSLSFAIGDGALPGNEGRGYVLRRLLRRAV 314
Cdd:COG0013 233 RIAAVLQGVHSNYETDLFRPLIEAAAELTGVKYGADEEdDVSLRVIADHIRAVAFLIADGVLPSNEGRGYVLRRILRRAV 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 315 MHGKKLGIQGKFLASLVPTVGKIMQSYYPEVLEKEDFIMQIIDREEETFNRTIDAGQKLIDELLVNLKSEGKDRLEGADI 394
Cdd:COG0013 313 RHGRLLGIKEPFLYKLVPVVVEEMGDAYPELKEKQELIEKVLKAEEERFLRTLERGLKLLDEAIAKLKAAGGKVLSGEDA 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 395 FRLYDTYGFPVELTEELAEDEGFKIDHEGFKVAMKAQQERARAAVVKGGSMGAQN--ETLSSIEVESEFL-YEDKTTQGK 471
Cdd:COG0013 393 FKLYDTYGFPLDLTEEIARERGLTVDEEGFEAAMEEQRERARAAAKFSGDAAVDGvwRELLEEGGPTEFVgYDTLEAEAK 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 472 LLVAIQDDEIVDEVSG--KAQLVFDVTPFYAEMGGQVADHGVIKDAEGqvVANVLDVQHAPHGQNLHSVETLS-PLKVGE 548
Cdd:COG0013 473 VLALVKDGELVDSAKAgeEVEVVLDRTPFYAESGGQVGDTGTIEGDGG--VFEVTDTQKPPGGLIVHIGKVEEgELKVGD 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 549 SYTLEIDKERRAAVVKNHTATHLLHAALHNIVGNHALQAGSLNEVEFLRFDFTHFAQVTKEELAEIERQVNEVIWQSLKV 628
Cdd:COG0013 551 TVTAQVDAERRRAIARNHSATHLLHAALREVLGEHVTQAGSLVAPDRLRFDFSHFEALTPEELAEIEDLVNEKIRENLPV 630
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 629 ETVETDIATAKEMGAMALFGEKYGKNVRVVKIGDYSIELCGGTHTQTTSEIGLFKIVKEEGIGSGVRRIIAVTGQKAYEA 708
Cdd:COG0013 631 ETREMPLDEAKALGAMALFGEKYGDEVRVVSIGDFSRELCGGTHVSRTGDIGLFKIVSESSVAAGVRRIEAVTGEAALEY 710
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 709 FKDAENTLNEVATMVKAPqTSQVLAKVTSLQDELKTAQKENDALAGKLAASQSDEIFKNVQTAGSLNFIASEVTVPDANG 788
Cdd:COG0013 711 LREQEALLKELAELLKAP-PEELPERVEALLEELKELEKELEQLKAKLASAAADDLLAQAEEIGGVKVLAARVEGVDAKD 789
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 789 LRNLADIWKQKELSDVLVLVAKIGEKVSLLVA-SK---SSDVKAGNLVKELAPFVDGRGGGKPDMAMAGGSKAAGIPELL 864
Cdd:COG0013 790 LRDLADDLKDKLGSGVVVLASVADGKVSLVAGvTKdlvKKGLKAGDLVKEVAKIVGGGGGGRPDMAQAGGKDPSKLDEAL 869
|
....*...
gi 545593678 865 AAVAEKLA 872
Cdd:COG0013 870 AAVKEWLA 877
|
|
| alaS |
TIGR00344 |
alanine--tRNA ligase; The model describes alanine--tRNA ligase. This enzyme catalyzes the ... |
8-854 |
0e+00 |
|
alanine--tRNA ligase; The model describes alanine--tRNA ligase. This enzyme catalyzes the reaction (tRNAala + L-alanine + ATP = L-alanyl-tRNAala + pyrophosphate + AMP). [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273026 [Multi-domain] Cd Length: 845 Bit Score: 951.82 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 8 EVRQMFLDFFKSKGHTVEPSQSLVPVNDPTLLWINSGVATLKKYFDGSVVPENPRLTNAQKAIRTNDIENVGKTARHHTM 87
Cdd:TIGR00344 1 EIRQTFLDFFKEKGHQVIPSAPLVPRNDPTLLLTNAGMAQFKPIFTGIVKPPSNRLTNAQPCIRLNDLENVGRTARHHTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 88 FEMLGNFSIGDYFRKEAIAFAWELLTSSewFEFPAEKLYITYYPADMDTYNRWVEVGVDPTHLVPI--EDNFWEIGAGPS 165
Cdd:TIGR00344 81 FEMLGNFSFGDYFKEEAIAFAWELLTEV--LGLDKERLYVTVYEDDEEAYKIWEKIGIPADRIIKCdaKDNFWDMGDGPC 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 166 GPDTEIFFDrgevydpeHVGLKLLAEDIENDRYIEIWNIVLSQFNADPSiprSEYPELPQKNIDTGMGLERMVCIIQGGK 245
Cdd:TIGR00344 159 GPCTEIYYD--------FVGGKPGEPLEENDRYLEVWNLVFMQFNRDPD---GNYTPLPKKNIDTGMGLERFVAVLQGVP 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 246 TNFDTDLFLPIIREIEKLSGKTYSPDSENM----------SFKVIADHIRSLSFAIGDGALPGNEGRGYVLRRLLRRAVM 315
Cdd:TIGR00344 228 TNYDTDIFLPLIEKIEEITGVKYDSNNAGImdekrvedlrSLRVIADHTRAIAFMLADGVVPSNEGRGYVLRRLIRRALR 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 316 HGKKLGIQGKFLASLVPTVGKIMQSYYPEVLEKEDFIMQIIDREEETFNRTIDAGQKLIDELlvnLKSEGKDRLEGADIF 395
Cdd:TIGR00344 308 HGKKLGLKEAFLYKLVPTLIEVLGDYYPELKEKQEFVEQILELEEERFAKTLERGLRLFEKL---LKKTGKKELDGEDAF 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 396 RLYDTYGFPVELTEELAEDEGFKIDHEGFKVAMKAQQERARAAVvkggSMGAQNETLSSIEVESEFL-YEDKTTQGKLLV 474
Cdd:TIGR00344 385 KLYDTYGFPVELTKEIAEERGLTVDMPGFEALMAEQRERSKQNS----QFQEQEIALVNVYPATEFLgYDDLEFEAKVIG 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 475 AIQDDEIVDEVSG--KAQLVFDVTPFYAEMGGQVADHGVIKDAEGQVvaNVLDVQHaPHGQNLHSVETLSP-LKVGESYT 551
Cdd:TIGR00344 461 LFDDGYLVEQALAgqSVYVILDQTPFYAESGGQIGDTGYLIANDGKF--RVVDVQK-PNGVVFHFGEVEGGsLKVGDKVI 537
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 552 LEIDKERRAAVVKNHTATHLLHAALHNIVGNHALQAGSLNEVEFLRFDFTHFAQVTKEELAEIERQVNEVIWQSLKVETV 631
Cdd:TIGR00344 538 AVIDEKRRFRIMRNHSATHLLHAALQKVLGNHVWQAGSLVSFKKLRFDFSHFRALTREELEEIEDLANEQILANIPIKVI 617
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 632 ETDIATAKEMGAMALFGEKY--GKNVRVVKIGDYSIELCGGTHTQTTSEIGLFKIVKEEGIGSGVRRIIAVTGQKAYEAF 709
Cdd:TIGR00344 618 FMDLDEAKRKGAFALFGEKYvpGEKVRVVSVGDFSVELCGGTHVRNTGEIGLFKIVKESGIAAGVRRIEAVTGEAAIEYL 697
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 710 KDAENTLNEVATMVKAPqTSQVLAKVTSLQDELKTAQKENDALAGKLAASQSDEIFKNVQTAGSLNFIASEVTVPDANGL 789
Cdd:TIGR00344 698 NEQEDKLKELADILKVT-PNELPKKVERFFEEWKALQKELESLKLKIADQKIDELKDKAETINGVKVLVEVVDAKDMKSL 776
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 545593678 790 RNLADIWKQKELSDVLVLVAKIGEKVSLLVASK----SSDVKAGNLVKELAPFVDGRGGGKPDMAMAGG 854
Cdd:TIGR00344 777 KTMADRLKSKLGSAIYVLASFAEGKVKLVCGVSndvlTKKIKAGELINQIAQVLGGKGGGRPDFAQGGG 845
|
|
| PLN02900 |
PLN02900 |
alanyl-tRNA synthetase |
1-872 |
0e+00 |
|
alanyl-tRNA synthetase
Pssm-ID: 215487 [Multi-domain] Cd Length: 936 Bit Score: 825.80 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 1 MKTMTSAEVRQMFLDFFKSKGHTVEPSQSLVPVNDPTLLWINSGVATLKKYFDGSVVPEN-----PRLTNAQKAIRT--- 72
Cdd:PLN02900 8 EKEWPGDRIRRTFLSFFESKGHTFLPSSPLVPVDDPTLLFTNAGMNQFKPIFLGTADPNTplrklPRATNTQKCIRAggk 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 73 -NDIENVGKTARHHTMFEMLGNFSIGDYFRKEAIAFAWELLTssEWFEFPAEKLYITYY------PADMDTYNRWVEVgV 145
Cdd:PLN02900 88 hNDLDDVGKDTYHHTFFEMLGNWSFGDYFKKEAIGWAWELLT--KVYGLPADRLYATYFggdekqAPDDEARAIWLDY-L 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 146 DPTHLVPI--EDNFWEIGA-GPSGPDTEIFFDRgevydpehVGLKLLAEDIEND--RYIEIWNIVLSQFNADPSipRSEY 220
Cdd:PLN02900 165 PEERVLPFgcKDNFWEMGDtGPCGPCSEIHYDR--------IGERDAADLVNNDdpRFIEIWNLVFIQFNREAD--GSLK 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 221 PeLPQKNIDTGMGLERMVCIIQGGKTNFDTDLFLPIIREIEK------LSGKTYSPDSEN--MSFKVIADHIRSLSFAIG 292
Cdd:PLN02900 235 P-LPAKHVDTGMGLERLASILQNKPSNYDTDLFMPIFDAIQEatgarpYAGKVGAEDDDRvdMAYRVVADHIRTLSFAIA 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 293 DGALPGNEGRGYVLRRLLRRAVMHGK-KLGIQGKFLASLVPTVGKIMQSYYPEVLEKEDFIMQIIDREEETFNRTIDAGQ 371
Cdd:PLN02900 314 DGVVPSNEGRGYVLRRLLRRAVRYGRlLLGAEEGFFPALVEVVVELSGDVFPEVKKNEKRITEIIAEEELSFGKTLEKGI 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 372 KLIDELLVNLKSEGKDRLEGADIFRLYDTYGFPVELTEELAEDEGFKIDHEGFKVAMKAQQERARAAVVKGGS----MGA 447
Cdd:PLN02900 394 EKFKKALAAAKANGGPVLSGKDAFLLYDTYGFPVDLTELMAEERGVTVDMEGFEAAMEEARERSRAAHLKAGGgaieLAA 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 448 QNE---TLSSIEVESEFL-YEDKTTQGKLLVAI-QDDEIVDEVSGKAQ--LVFDVTPFYAEMGGQVADHGVIKDAEGQVV 520
Cdd:PLN02900 474 EATswlQKQGVAATDDFLkYDWLSDHEAVVKAIlTGGGFVESVSEGDEvgIVLDKTSFYAESGGQIGDTGVLEGSGGAVV 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 521 aNVLDVQHAPhGQNLHSVE-TLSPLKVGESYTLEIDKERRAAVVKNHTATHLLHAALHNIVGNHALQAGSLNEVEFLRFD 599
Cdd:PLN02900 554 -EVSDVQKAG-GFVLHIGTvTEGSVSVGDAVTCKVDYDRRRRIAPNHTATHLLNSALKEVLGDHVDQKGSLVAFEKLRFD 631
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 600 FTHFAQVTKEELAEIERQVNEVIWQSLKVETVETDIATAKE-MGAMALFGEKYGKNVRVVKIGD-YSIELCGGTHTQTTS 677
Cdd:PLN02900 632 FSHGKPMTPEELREVESLVNEWIGDALPVEAKEMPLADAKRiNGLRAVFGEKYPDPVRVVSVGGvYSMELCGGTHVSNTA 711
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 678 EIGLFKIVKEEGIGSGVRRIIAVTGQKAYEAFKDAENTLNEVATMVK-----------------------APQTSQVLAK 734
Cdd:PLN02900 712 EAEAFKLLSEEGIAKGIRRITAVTGGAAVEAINAADSLERELDSALKvegsdlekkvaslksrvdaavipAAKKEEIRAR 791
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 735 VTSLQDELKTAQKENDALAGKLAASQSDEIFKNVQTAGSLNFIASEVTVPDANGLRNLAD--IWKQKELSDVLVLVAKIG 812
Cdd:PLN02900 792 VSALQKELRAAQKEAAALRAKLAVAKATELASKALSAGKSVLVARLDVGVDAAALKEAAEkvIAKLGDPAAVVLSSDEEK 871
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 545593678 813 EKVSLLVA----SKSSDVKAGNLVKELAPFVDGRGGGKPDMAMAGGSKAAGIPELLAAvAEKLA 872
Cdd:PLN02900 872 GKVSLVAAvppgVVKKGLKAGKWLGAIAKLCGGGGGGKPGFAQGQGRDAEKLDAALEK-ARAFA 934
|
|
| tRNA-synt_2c |
pfam01411 |
tRNA synthetases class II (A); Other tRNA synthetase sub-families are too dissimilar to be ... |
8-558 |
0e+00 |
|
tRNA synthetases class II (A); Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only alanyl-tRNA synthetases.
Pssm-ID: 279719 [Multi-domain] Cd Length: 548 Bit Score: 661.28 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 8 EVRQMFLDFFKSKGHTVEPSQSLVPVNDPTLLWINSGVATLKKYFDGSVV-PENPRLTNAQKAIRTNDIENVGKTARHHT 86
Cdd:pfam01411 1 EIRQTFLDFFEKKGHTRVPSSPVVPRNDPTLLFTNAGMNQFKPIFLGGVAkPPYNRATNSQKCIRAGDLENVGRTGRHHT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 87 MFEMLGNFSIGDYFRKEAIAFAWELLTssEWFEFPAEKLYITYYPADMDTYNRW-VEVGVDPTHLVPI--EDNFWEIGA- 162
Cdd:pfam01411 81 FFEMLGNFSFGDYFKEEAIEYAWELLT--KELGLPPERLYVTVFEWDDEAGPIWeKIVGGPEERILRFgdKDNFWEMGDt 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 163 GPSGPDTEIFFDRGEVYDPEHVGLKLLAEDienDRYIEIWNIVLSQFNADPSIPRSEypeLPQKNIDTGMGLERMVCIIQ 242
Cdd:pfam01411 159 GPCGPCSEIDYDRGEEIGGWDSGGTPTADD---DRFLEIWNLVFMQFNRENDGTLKP---LPKKSIDTGMGLERLVAVLQ 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 243 GGKTNFDTDLFLPIIREIEKLSGKTYSPDSE-NMSFKVIADHIRSLSFAIGDGALPGNEGRGYVLRRLLRRAVMHGKKLG 321
Cdd:pfam01411 233 DVRSNYDTDVFIPVIELIEEISGARYYTVDEtDEAYRVIADHTRALTFALADGVVPSNEGRGYVLRRILRRAVRHAKKLG 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 322 IQGKFLASLVPTVGKIMQSYYPEVLEKEDFIMQIIDREEETFNRTIDAGQKLIDELLVNLKsEGKDRLEGADIFRLYDTY 401
Cdd:pfam01411 313 LKEPFLYDLVPTVVEVLGDAYPELKEDEDFIQEILELEEERFAKTLERGLRLLERLIAKLK-KGKKTLPGEDAFKLYDTY 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 402 GFPVELTEELAEDEGFKIDHEGFKVAMKAQQERARAAvVKGGSMGAQNETLSSIEVESEFL-YEDKTTQGKLLVAIQDDE 480
Cdd:pfam01411 392 GFPVDLTKEIAEERGLKVDMPGFEYAMVEQRERSKQA-VKEKGEKLDVSALKELPATTEFLgYDDLESEAKILALPKDGE 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 481 IVDEVSG--KAQLVFDVTPFYAEMGGQVADHGVIKDaeGQVVANVLDVQhAPHGQNLHSVETLS-PLKVGESYTLEIDKE 557
Cdd:pfam01411 471 FVAEVLAgqEGGVILDRTPFYAESGGQIGDTGYIIG--DGGEFRVTDVQ-KYGGVVVHKGKLESgKLKVGDKVIAVIDED 547
|
.
gi 545593678 558 R 558
Cdd:pfam01411 548 R 548
|
|
| AlaRS_core |
cd00673 |
Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is ... |
6-243 |
6.23e-109 |
|
Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. Class II assignment is based upon its predicted structure and the presence of three characteristic sequence motifs.
Pssm-ID: 238360 [Multi-domain] Cd Length: 232 Bit Score: 333.94 E-value: 6.23e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 6 SAEVRQMFLDFFKSKGHTVEPSQSLVPVNDPTLLWINSGVATLKKYFDGSVVPENPRLTNAQKAIRTNDIENVGKTARHH 85
Cdd:cd00673 1 ASEIRETFLSFFEKKGHTRVPSSPVVPRDDPTLLFTNAGMNQFKPIFLGEVPPPANRLVNSQKCIRAGDIDNVGKTGRHH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 86 TMFEMLGNFSIGDYFRKEAIAFAWELLTSSewFEFPAEKLYITYYPADMDTYNRWVE-VGVDPTHLVPI--EDNFWEIG- 161
Cdd:cd00673 81 TFFEMLGNFSFGDYFKEEAIAFAWELLTEV--LGLPKDRLYVSVFEGDDEEEAIWWWkIGLPGIRIERIgfKDNFWEMGg 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 162 AGPSGPDTEIFFDRGEVYDPEHVglkllaEDIENDRYIEIWNIVLSQFNADPSIPrseYPELPQKNIDTGMGLERMVCII 241
Cdd:cd00673 159 NGPCGPCSEIFYDRGEERDAASL------PNEDDDRYLEIWNLVFMQYNRDADGT---YRPLPKKIVDTGMGLERLVWVL 229
|
..
gi 545593678 242 QG 243
Cdd:cd00673 230 QG 231
|
|
| tRNA_SAD |
smart00863 |
Threonyl and Alanyl tRNA synthetase second additional domain; The catalytically active form of ... |
655-697 |
1.27e-20 |
|
Threonyl and Alanyl tRNA synthetase second additional domain; The catalytically active form of threonyl/alanyl tRNA synthetase is a dimer. Within the tRNA synthetase class II dimer, the bound tRNA interacts with both monomers making specific interactions with the catalytic domain, the C-terminal domain, and this SAD domain (the second additional domain). The second additional domain is comprised of a pair of perpendicularly orientated antiparallel beta sheets, of four and three strands, respectively, that surround a central alpha helix that forms the core of the domain.
Pssm-ID: 197931 [Multi-domain] Cd Length: 43 Bit Score: 85.51 E-value: 1.27e-20
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 545593678 655 VRVVKIGDYSIELCGGTHTQTTSEIGLFKIVKEEGIGSGVRRI 697
Cdd:smart00863 1 VRVVSIGDFSVELCGGTHVPNTGEIGAFKILSVSGAYWGLQRI 43
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| AlaS |
COG0013 |
Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Alanyl-tRNA ... |
4-872 |
0e+00 |
|
Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Alanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439784 [Multi-domain] Cd Length: 880 Bit Score: 1313.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 4 MTSAEVRQMFLDFFKSKGHTVEPSQSLVPVNDPTLLWINSGVATLKKYFDGSVVPENPRLTNAQKAIRT----NDIENVG 79
Cdd:COG0013 2 MTSAEIRQKFLDFFESKGHTIVPSSSLVPKNDPTLLFTNAGMVQFKPYFLGQEKPPYPRATTSQKCVRTggkhNDLENVG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 80 KTARHHTMFEMLGNFSIGDYFRKEAIAFAWELLTssEWFEFPAEKLYITYYPADMDTYNRWV-EVGVDPTHLVPI--EDN 156
Cdd:COG0013 82 YTARHHTFFEMLGNFSFGDYFKEEAIAWAWELLT--EVLGLPKERLWVTVYEDDDEAYDIWKkEIGVPEERIIRLgkKDN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 157 FWEIGA-GPSGPDTEIFFDRGEVYDPEHVGLkllaEDIENDRYIEIWNIVLSQFNADPSiprSEYPELPQKNIDTGMGLE 235
Cdd:COG0013 160 FWEMGDtGPCGPCSEIFYDRGPEYGGGPPGS----PGEDGDRYIEIWNLVFMQFNRDED---GTLTPLPKKNIDTGMGLE 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 236 RMVCIIQGGKTNFDTDLFLPIIREIEKLSGKTYSPDSE-NMSFKVIADHIRSLSFAIGDGALPGNEGRGYVLRRLLRRAV 314
Cdd:COG0013 233 RIAAVLQGVHSNYETDLFRPLIEAAAELTGVKYGADEEdDVSLRVIADHIRAVAFLIADGVLPSNEGRGYVLRRILRRAV 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 315 MHGKKLGIQGKFLASLVPTVGKIMQSYYPEVLEKEDFIMQIIDREEETFNRTIDAGQKLIDELLVNLKSEGKDRLEGADI 394
Cdd:COG0013 313 RHGRLLGIKEPFLYKLVPVVVEEMGDAYPELKEKQELIEKVLKAEEERFLRTLERGLKLLDEAIAKLKAAGGKVLSGEDA 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 395 FRLYDTYGFPVELTEELAEDEGFKIDHEGFKVAMKAQQERARAAVVKGGSMGAQN--ETLSSIEVESEFL-YEDKTTQGK 471
Cdd:COG0013 393 FKLYDTYGFPLDLTEEIARERGLTVDEEGFEAAMEEQRERARAAAKFSGDAAVDGvwRELLEEGGPTEFVgYDTLEAEAK 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 472 LLVAIQDDEIVDEVSG--KAQLVFDVTPFYAEMGGQVADHGVIKDAEGqvVANVLDVQHAPHGQNLHSVETLS-PLKVGE 548
Cdd:COG0013 473 VLALVKDGELVDSAKAgeEVEVVLDRTPFYAESGGQVGDTGTIEGDGG--VFEVTDTQKPPGGLIVHIGKVEEgELKVGD 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 549 SYTLEIDKERRAAVVKNHTATHLLHAALHNIVGNHALQAGSLNEVEFLRFDFTHFAQVTKEELAEIERQVNEVIWQSLKV 628
Cdd:COG0013 551 TVTAQVDAERRRAIARNHSATHLLHAALREVLGEHVTQAGSLVAPDRLRFDFSHFEALTPEELAEIEDLVNEKIRENLPV 630
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 629 ETVETDIATAKEMGAMALFGEKYGKNVRVVKIGDYSIELCGGTHTQTTSEIGLFKIVKEEGIGSGVRRIIAVTGQKAYEA 708
Cdd:COG0013 631 ETREMPLDEAKALGAMALFGEKYGDEVRVVSIGDFSRELCGGTHVSRTGDIGLFKIVSESSVAAGVRRIEAVTGEAALEY 710
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 709 FKDAENTLNEVATMVKAPqTSQVLAKVTSLQDELKTAQKENDALAGKLAASQSDEIFKNVQTAGSLNFIASEVTVPDANG 788
Cdd:COG0013 711 LREQEALLKELAELLKAP-PEELPERVEALLEELKELEKELEQLKAKLASAAADDLLAQAEEIGGVKVLAARVEGVDAKD 789
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 789 LRNLADIWKQKELSDVLVLVAKIGEKVSLLVA-SK---SSDVKAGNLVKELAPFVDGRGGGKPDMAMAGGSKAAGIPELL 864
Cdd:COG0013 790 LRDLADDLKDKLGSGVVVLASVADGKVSLVAGvTKdlvKKGLKAGDLVKEVAKIVGGGGGGRPDMAQAGGKDPSKLDEAL 869
|
....*...
gi 545593678 865 AAVAEKLA 872
Cdd:COG0013 870 AAVKEWLA 877
|
|
| alaS |
TIGR00344 |
alanine--tRNA ligase; The model describes alanine--tRNA ligase. This enzyme catalyzes the ... |
8-854 |
0e+00 |
|
alanine--tRNA ligase; The model describes alanine--tRNA ligase. This enzyme catalyzes the reaction (tRNAala + L-alanine + ATP = L-alanyl-tRNAala + pyrophosphate + AMP). [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273026 [Multi-domain] Cd Length: 845 Bit Score: 951.82 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 8 EVRQMFLDFFKSKGHTVEPSQSLVPVNDPTLLWINSGVATLKKYFDGSVVPENPRLTNAQKAIRTNDIENVGKTARHHTM 87
Cdd:TIGR00344 1 EIRQTFLDFFKEKGHQVIPSAPLVPRNDPTLLLTNAGMAQFKPIFTGIVKPPSNRLTNAQPCIRLNDLENVGRTARHHTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 88 FEMLGNFSIGDYFRKEAIAFAWELLTSSewFEFPAEKLYITYYPADMDTYNRWVEVGVDPTHLVPI--EDNFWEIGAGPS 165
Cdd:TIGR00344 81 FEMLGNFSFGDYFKEEAIAFAWELLTEV--LGLDKERLYVTVYEDDEEAYKIWEKIGIPADRIIKCdaKDNFWDMGDGPC 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 166 GPDTEIFFDrgevydpeHVGLKLLAEDIENDRYIEIWNIVLSQFNADPSiprSEYPELPQKNIDTGMGLERMVCIIQGGK 245
Cdd:TIGR00344 159 GPCTEIYYD--------FVGGKPGEPLEENDRYLEVWNLVFMQFNRDPD---GNYTPLPKKNIDTGMGLERFVAVLQGVP 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 246 TNFDTDLFLPIIREIEKLSGKTYSPDSENM----------SFKVIADHIRSLSFAIGDGALPGNEGRGYVLRRLLRRAVM 315
Cdd:TIGR00344 228 TNYDTDIFLPLIEKIEEITGVKYDSNNAGImdekrvedlrSLRVIADHTRAIAFMLADGVVPSNEGRGYVLRRLIRRALR 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 316 HGKKLGIQGKFLASLVPTVGKIMQSYYPEVLEKEDFIMQIIDREEETFNRTIDAGQKLIDELlvnLKSEGKDRLEGADIF 395
Cdd:TIGR00344 308 HGKKLGLKEAFLYKLVPTLIEVLGDYYPELKEKQEFVEQILELEEERFAKTLERGLRLFEKL---LKKTGKKELDGEDAF 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 396 RLYDTYGFPVELTEELAEDEGFKIDHEGFKVAMKAQQERARAAVvkggSMGAQNETLSSIEVESEFL-YEDKTTQGKLLV 474
Cdd:TIGR00344 385 KLYDTYGFPVELTKEIAEERGLTVDMPGFEALMAEQRERSKQNS----QFQEQEIALVNVYPATEFLgYDDLEFEAKVIG 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 475 AIQDDEIVDEVSG--KAQLVFDVTPFYAEMGGQVADHGVIKDAEGQVvaNVLDVQHaPHGQNLHSVETLSP-LKVGESYT 551
Cdd:TIGR00344 461 LFDDGYLVEQALAgqSVYVILDQTPFYAESGGQIGDTGYLIANDGKF--RVVDVQK-PNGVVFHFGEVEGGsLKVGDKVI 537
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 552 LEIDKERRAAVVKNHTATHLLHAALHNIVGNHALQAGSLNEVEFLRFDFTHFAQVTKEELAEIERQVNEVIWQSLKVETV 631
Cdd:TIGR00344 538 AVIDEKRRFRIMRNHSATHLLHAALQKVLGNHVWQAGSLVSFKKLRFDFSHFRALTREELEEIEDLANEQILANIPIKVI 617
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 632 ETDIATAKEMGAMALFGEKY--GKNVRVVKIGDYSIELCGGTHTQTTSEIGLFKIVKEEGIGSGVRRIIAVTGQKAYEAF 709
Cdd:TIGR00344 618 FMDLDEAKRKGAFALFGEKYvpGEKVRVVSVGDFSVELCGGTHVRNTGEIGLFKIVKESGIAAGVRRIEAVTGEAAIEYL 697
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 710 KDAENTLNEVATMVKAPqTSQVLAKVTSLQDELKTAQKENDALAGKLAASQSDEIFKNVQTAGSLNFIASEVTVPDANGL 789
Cdd:TIGR00344 698 NEQEDKLKELADILKVT-PNELPKKVERFFEEWKALQKELESLKLKIADQKIDELKDKAETINGVKVLVEVVDAKDMKSL 776
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 545593678 790 RNLADIWKQKELSDVLVLVAKIGEKVSLLVASK----SSDVKAGNLVKELAPFVDGRGGGKPDMAMAGG 854
Cdd:TIGR00344 777 KTMADRLKSKLGSAIYVLASFAEGKVKLVCGVSndvlTKKIKAGELINQIAQVLGGKGGGRPDFAQGGG 845
|
|
| PLN02900 |
PLN02900 |
alanyl-tRNA synthetase |
1-872 |
0e+00 |
|
alanyl-tRNA synthetase
Pssm-ID: 215487 [Multi-domain] Cd Length: 936 Bit Score: 825.80 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 1 MKTMTSAEVRQMFLDFFKSKGHTVEPSQSLVPVNDPTLLWINSGVATLKKYFDGSVVPEN-----PRLTNAQKAIRT--- 72
Cdd:PLN02900 8 EKEWPGDRIRRTFLSFFESKGHTFLPSSPLVPVDDPTLLFTNAGMNQFKPIFLGTADPNTplrklPRATNTQKCIRAggk 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 73 -NDIENVGKTARHHTMFEMLGNFSIGDYFRKEAIAFAWELLTssEWFEFPAEKLYITYY------PADMDTYNRWVEVgV 145
Cdd:PLN02900 88 hNDLDDVGKDTYHHTFFEMLGNWSFGDYFKKEAIGWAWELLT--KVYGLPADRLYATYFggdekqAPDDEARAIWLDY-L 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 146 DPTHLVPI--EDNFWEIGA-GPSGPDTEIFFDRgevydpehVGLKLLAEDIEND--RYIEIWNIVLSQFNADPSipRSEY 220
Cdd:PLN02900 165 PEERVLPFgcKDNFWEMGDtGPCGPCSEIHYDR--------IGERDAADLVNNDdpRFIEIWNLVFIQFNREAD--GSLK 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 221 PeLPQKNIDTGMGLERMVCIIQGGKTNFDTDLFLPIIREIEK------LSGKTYSPDSEN--MSFKVIADHIRSLSFAIG 292
Cdd:PLN02900 235 P-LPAKHVDTGMGLERLASILQNKPSNYDTDLFMPIFDAIQEatgarpYAGKVGAEDDDRvdMAYRVVADHIRTLSFAIA 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 293 DGALPGNEGRGYVLRRLLRRAVMHGK-KLGIQGKFLASLVPTVGKIMQSYYPEVLEKEDFIMQIIDREEETFNRTIDAGQ 371
Cdd:PLN02900 314 DGVVPSNEGRGYVLRRLLRRAVRYGRlLLGAEEGFFPALVEVVVELSGDVFPEVKKNEKRITEIIAEEELSFGKTLEKGI 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 372 KLIDELLVNLKSEGKDRLEGADIFRLYDTYGFPVELTEELAEDEGFKIDHEGFKVAMKAQQERARAAVVKGGS----MGA 447
Cdd:PLN02900 394 EKFKKALAAAKANGGPVLSGKDAFLLYDTYGFPVDLTELMAEERGVTVDMEGFEAAMEEARERSRAAHLKAGGgaieLAA 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 448 QNE---TLSSIEVESEFL-YEDKTTQGKLLVAI-QDDEIVDEVSGKAQ--LVFDVTPFYAEMGGQVADHGVIKDAEGQVV 520
Cdd:PLN02900 474 EATswlQKQGVAATDDFLkYDWLSDHEAVVKAIlTGGGFVESVSEGDEvgIVLDKTSFYAESGGQIGDTGVLEGSGGAVV 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 521 aNVLDVQHAPhGQNLHSVE-TLSPLKVGESYTLEIDKERRAAVVKNHTATHLLHAALHNIVGNHALQAGSLNEVEFLRFD 599
Cdd:PLN02900 554 -EVSDVQKAG-GFVLHIGTvTEGSVSVGDAVTCKVDYDRRRRIAPNHTATHLLNSALKEVLGDHVDQKGSLVAFEKLRFD 631
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 600 FTHFAQVTKEELAEIERQVNEVIWQSLKVETVETDIATAKE-MGAMALFGEKYGKNVRVVKIGD-YSIELCGGTHTQTTS 677
Cdd:PLN02900 632 FSHGKPMTPEELREVESLVNEWIGDALPVEAKEMPLADAKRiNGLRAVFGEKYPDPVRVVSVGGvYSMELCGGTHVSNTA 711
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 678 EIGLFKIVKEEGIGSGVRRIIAVTGQKAYEAFKDAENTLNEVATMVK-----------------------APQTSQVLAK 734
Cdd:PLN02900 712 EAEAFKLLSEEGIAKGIRRITAVTGGAAVEAINAADSLERELDSALKvegsdlekkvaslksrvdaavipAAKKEEIRAR 791
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 735 VTSLQDELKTAQKENDALAGKLAASQSDEIFKNVQTAGSLNFIASEVTVPDANGLRNLAD--IWKQKELSDVLVLVAKIG 812
Cdd:PLN02900 792 VSALQKELRAAQKEAAALRAKLAVAKATELASKALSAGKSVLVARLDVGVDAAALKEAAEkvIAKLGDPAAVVLSSDEEK 871
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 545593678 813 EKVSLLVA----SKSSDVKAGNLVKELAPFVDGRGGGKPDMAMAGGSKAAGIPELLAAvAEKLA 872
Cdd:PLN02900 872 GKVSLVAAvppgVVKKGLKAGKWLGAIAKLCGGGGGGKPGFAQGQGRDAEKLDAALEK-ARAFA 934
|
|
| tRNA-synt_2c |
pfam01411 |
tRNA synthetases class II (A); Other tRNA synthetase sub-families are too dissimilar to be ... |
8-558 |
0e+00 |
|
tRNA synthetases class II (A); Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only alanyl-tRNA synthetases.
Pssm-ID: 279719 [Multi-domain] Cd Length: 548 Bit Score: 661.28 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 8 EVRQMFLDFFKSKGHTVEPSQSLVPVNDPTLLWINSGVATLKKYFDGSVV-PENPRLTNAQKAIRTNDIENVGKTARHHT 86
Cdd:pfam01411 1 EIRQTFLDFFEKKGHTRVPSSPVVPRNDPTLLFTNAGMNQFKPIFLGGVAkPPYNRATNSQKCIRAGDLENVGRTGRHHT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 87 MFEMLGNFSIGDYFRKEAIAFAWELLTssEWFEFPAEKLYITYYPADMDTYNRW-VEVGVDPTHLVPI--EDNFWEIGA- 162
Cdd:pfam01411 81 FFEMLGNFSFGDYFKEEAIEYAWELLT--KELGLPPERLYVTVFEWDDEAGPIWeKIVGGPEERILRFgdKDNFWEMGDt 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 163 GPSGPDTEIFFDRGEVYDPEHVGLKLLAEDienDRYIEIWNIVLSQFNADPSIPRSEypeLPQKNIDTGMGLERMVCIIQ 242
Cdd:pfam01411 159 GPCGPCSEIDYDRGEEIGGWDSGGTPTADD---DRFLEIWNLVFMQFNRENDGTLKP---LPKKSIDTGMGLERLVAVLQ 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 243 GGKTNFDTDLFLPIIREIEKLSGKTYSPDSE-NMSFKVIADHIRSLSFAIGDGALPGNEGRGYVLRRLLRRAVMHGKKLG 321
Cdd:pfam01411 233 DVRSNYDTDVFIPVIELIEEISGARYYTVDEtDEAYRVIADHTRALTFALADGVVPSNEGRGYVLRRILRRAVRHAKKLG 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 322 IQGKFLASLVPTVGKIMQSYYPEVLEKEDFIMQIIDREEETFNRTIDAGQKLIDELLVNLKsEGKDRLEGADIFRLYDTY 401
Cdd:pfam01411 313 LKEPFLYDLVPTVVEVLGDAYPELKEDEDFIQEILELEEERFAKTLERGLRLLERLIAKLK-KGKKTLPGEDAFKLYDTY 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 402 GFPVELTEELAEDEGFKIDHEGFKVAMKAQQERARAAvVKGGSMGAQNETLSSIEVESEFL-YEDKTTQGKLLVAIQDDE 480
Cdd:pfam01411 392 GFPVDLTKEIAEERGLKVDMPGFEYAMVEQRERSKQA-VKEKGEKLDVSALKELPATTEFLgYDDLESEAKILALPKDGE 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 481 IVDEVSG--KAQLVFDVTPFYAEMGGQVADHGVIKDaeGQVVANVLDVQhAPHGQNLHSVETLS-PLKVGESYTLEIDKE 557
Cdd:pfam01411 471 FVAEVLAgqEGGVILDRTPFYAESGGQIGDTGYIIG--DGGEFRVTDVQ-KYGGVVVHKGKLESgKLKVGDKVIAVIDED 547
|
.
gi 545593678 558 R 558
Cdd:pfam01411 548 R 548
|
|
| PRK01584 |
PRK01584 |
alanyl-tRNA synthetase; Provisional |
4-700 |
1.54e-178 |
|
alanyl-tRNA synthetase; Provisional
Pssm-ID: 234962 [Multi-domain] Cd Length: 594 Bit Score: 527.80 E-value: 1.54e-178
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 4 MTSAEVRQMFLDFFKSKGHTVEPSQSLVPVNDPTLLWINSGVATLKKYFDGSVVPENPRLTNAQKAIRTNDIENVGKtAR 83
Cdd:PRK01584 1 MTLDELRKKYIDFFKSKGHVEIAGKSLIPENDPTVLFTTAGMHPLVPYLLGEPHPSGTRLVDVQKCLRTGDIDEVGD-LS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 84 HHTMFEMLGNFSIGDYFRKEAIAFAWELLTSSEWFEFPAEKLYITYY------PADMDTYNRWVEVGV--DPTHLVPIED 155
Cdd:PRK01584 80 HLTFFEMLGNWSLGAYFKEESIKYSFEFLTSPDYLNIPKDKLYVTVFegdeeiPRDEETASVWESLGIpkDRIFYLSREH 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 156 NFW-EIG-AGPSGPDTEIFFDRGEvydpEHVGLKLlaeDIEND--RYIEIWNIVLSQFNADPSiprSEYPELPQKNIDTG 231
Cdd:PRK01584 160 NWWgPVGeTGPCGPDTEIFVDTGK----PKCSVNC---RPTCScgKYFEIWNNVFMQYNKDED---GNYEELKRKCVDTG 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 232 MGLERMVCIIQGGKTNFDTDLFLPIIREIEKLSGKTYSPDSE-NMSFKVIADHIRSLSFAIGD--GALPGNEGRGYVLRR 308
Cdd:PRK01584 230 MGIERTIAFLQGKSSVYDTEAFTPIIKRIEKISGKIYGQNEEdDRSIRIIADHIRAACFILGDpfVVLPSNVGQGYVLRR 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 309 LLRRAVMHGKKLGIQGKFLASLVPTVGKIMQSYYPEVLEKEDFIMQIIDREEETFNRTIDAGQKLIDELLVNLKSEGKdr 388
Cdd:PRK01584 310 LIRRSIRHAKKLGIESHFLADLVDSVEEIYGSFYPELTEKKDFIKEELNKEEEKFFKTLRKGEQEFIKLIPNLGSSKI-- 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 389 LEGADIFRLYDTYGFPVELTEELAEDEGFKIDHEGFKVAMKAQQERARaavvKGGsmgaqnetlssieveseflyeDKTT 468
Cdd:PRK01584 388 IPGDIAFKLYDTYGFPYEITEELASEYGFTVDREGFDEHFKKHQKVSK----KGA---------------------DKVF 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 469 QGKLlvaiqddeivdevsgkaqlvfdvtpfyaemggqvADhgvikdaegqvvanvldvqhaphgqnlHSVETlsplkvge 548
Cdd:PRK01584 443 KGGL----------------------------------AD---------------------------HSYET-------- 453
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 549 sytleidkerraavVKNHTATHLLHAALHNIVGNHALQAGSLNEVEFLRFDFTHFAQVTKEELAEIERQVNEVIWQSLKV 628
Cdd:PRK01584 454 --------------TKLHTATHLLHKALRLVLGDHVRQKGSNITAERLRFDFSHPEKMTDDEIKKVEDIVNLQIKNDLSV 519
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 545593678 629 ETVETDIATAKEMGAMALFGEKYGKNVRVVKIGDYSIELCGGTHTQTTSEIGLFKIVKEEGIGSGVRRIIAV 700
Cdd:PRK01584 520 KKEVMSLEEAREKGAMALFGEKYEDIVKVYEIDGFSKEVCGGPHVENTGELGTFKIQKEQSSSSGVRRIRAI 591
|
|
| AlaRS_core |
cd00673 |
Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is ... |
6-243 |
6.23e-109 |
|
Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. Class II assignment is based upon its predicted structure and the presence of three characteristic sequence motifs.
Pssm-ID: 238360 [Multi-domain] Cd Length: 232 Bit Score: 333.94 E-value: 6.23e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 6 SAEVRQMFLDFFKSKGHTVEPSQSLVPVNDPTLLWINSGVATLKKYFDGSVVPENPRLTNAQKAIRTNDIENVGKTARHH 85
Cdd:cd00673 1 ASEIRETFLSFFEKKGHTRVPSSPVVPRDDPTLLFTNAGMNQFKPIFLGEVPPPANRLVNSQKCIRAGDIDNVGKTGRHH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 86 TMFEMLGNFSIGDYFRKEAIAFAWELLTSSewFEFPAEKLYITYYPADMDTYNRWVE-VGVDPTHLVPI--EDNFWEIG- 161
Cdd:cd00673 81 TFFEMLGNFSFGDYFKEEAIAFAWELLTEV--LGLPKDRLYVSVFEGDDEEEAIWWWkIGLPGIRIERIgfKDNFWEMGg 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 162 AGPSGPDTEIFFDRGEVYDPEHVglkllaEDIENDRYIEIWNIVLSQFNADPSIPrseYPELPQKNIDTGMGLERMVCII 241
Cdd:cd00673 159 NGPCGPCSEIFYDRGEERDAASL------PNEDDDRYLEIWNLVFMQYNRDADGT---YRPLPKKIVDTGMGLERLVWVL 229
|
..
gi 545593678 242 QG 243
Cdd:cd00673 230 QG 231
|
|
| AlaX |
COG2872 |
Ser-tRNA(Ala) deacylase AlaX (editing enzyme) [Translation, ribosomal structure and biogenesis] ... |
482-697 |
3.04e-39 |
|
Ser-tRNA(Ala) deacylase AlaX (editing enzyme) [Translation, ribosomal structure and biogenesis];
Pssm-ID: 442119 [Multi-domain] Cd Length: 238 Bit Score: 145.72 E-value: 3.04e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 482 VDEVSGKAQLVFDVTPFYAEMGGQVADHGVIKdAEGQVVAnVLDVQHApHGQNLHSVETLSPLKVGESYTLEIDKERRAA 561
Cdd:COG2872 19 VTAVTEEGGVVLDRTAFYPTGGGQPGDTGTLV-WDGKEIR-VVDVRKE-DGEIVHVLEGAPLPEVGDEVTGEIDWERRYR 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 562 VVKNHTATHLLHAALHN-----IVGNHalqagsLNEvEFLRFDFtHFAQVTKEELAEIERQVNEVIWQSLKVETvetDIA 636
Cdd:COG2872 96 HMRLHTALHLLSAVVYReygapVTGGQ------IGE-DRARIDF-DLPEFDEEDLEEIEAEANELIAADLPVRI---YWI 164
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 545593678 637 TAKEMGA-------MALFGEKYGKNVRVVKIGDYSIELCGGTHTQTTSEIGLFKIVKEEGIGSGVRRI 697
Cdd:COG2872 165 TREELEAipglvrtMSVLPPPGVGRVRIVEIGGVDLQPCGGTHVANTGEIGRIKITKIEKKGKGNRRV 232
|
|
| tRNA_SAD |
smart00863 |
Threonyl and Alanyl tRNA synthetase second additional domain; The catalytically active form of ... |
655-697 |
1.27e-20 |
|
Threonyl and Alanyl tRNA synthetase second additional domain; The catalytically active form of threonyl/alanyl tRNA synthetase is a dimer. Within the tRNA synthetase class II dimer, the bound tRNA interacts with both monomers making specific interactions with the catalytic domain, the C-terminal domain, and this SAD domain (the second additional domain). The second additional domain is comprised of a pair of perpendicularly orientated antiparallel beta sheets, of four and three strands, respectively, that surround a central alpha helix that forms the core of the domain.
Pssm-ID: 197931 [Multi-domain] Cd Length: 43 Bit Score: 85.51 E-value: 1.27e-20
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 545593678 655 VRVVKIGDYSIELCGGTHTQTTSEIGLFKIVKEEGIGSGVRRI 697
Cdd:smart00863 1 VRVVSIGDFSVELCGGTHVPNTGEIGAFKILSVSGAYWGLQRI 43
|
|
| DHHA1 |
pfam02272 |
DHHA1 domain; This domain is often found adjacent to the DHH domain pfam01368 and is called ... |
735-869 |
2.34e-20 |
|
DHHA1 domain; This domain is often found adjacent to the DHH domain pfam01368 and is called DHHA1 for DHH associated domain. This domain is diagnostic of DHH subfamily 1 members. This domains is also found in alanyl tRNA synthetase, suggesting that this domain may have an RNA binding function. The domain is about 60 residues long and contains a conserved GG motif.
Pssm-ID: 396724 [Multi-domain] Cd Length: 139 Bit Score: 87.88 E-value: 2.34e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 735 VTSLQDELKTAQKENDALAGKLAASQSDEIFKNVQTAGSLNFIASEV-TVPDANGLRNLADIWKQKELSDVLVLVAKI-G 812
Cdd:pfam02272 1 LESLNEELKELEKELEELKEALALLKAKELLEKAEEINGVKVLVAEVgEGWDAGALGIAADRLKKKLGDPVIVLVAKEdG 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 545593678 813 EKVSLLVASKSSD-VKAGNLVKELAPFVDGRGGGKpDMAMAGGSKAAGIPELLAAVAE 869
Cdd:pfam02272 81 DKVKVSARSSKDKgVDAGELLKEVAAILGGGGGGH-DLAAGAGIDAEKLDEALELLEE 137
|
|
| tRNA_SAD |
pfam07973 |
Threonyl and Alanyl tRNA synthetase second additional domain; The catalytically active from of ... |
655-697 |
2.60e-19 |
|
Threonyl and Alanyl tRNA synthetase second additional domain; The catalytically active from of threonyl/alanyl tRNA synthetase is a dimer. Within the tRNA synthetase class II dimer, the bound tRNA interacts with both monomers making specific interactions with the catalytic domain, the C-terminal domain, and this domain (the second additional domain). The second additional domain is comprised of a pair of perpendicularly orientated antiparallel beta sheets, of four and three strands, respectively, that surround a central alpha helix that forms the core of the domain.
Pssm-ID: 429764 [Multi-domain] Cd Length: 43 Bit Score: 81.72 E-value: 2.60e-19
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 545593678 655 VRVVKIGDYSIELCGGTHTQTTSEIGLFKIVKEEGIGSGVRRI 697
Cdd:pfam07973 1 VRVVSIGDFDVDLCGGTHVPNTGEIGAFKILKGESKNKGLRRI 43
|
|
| PLN02961 |
PLN02961 |
alanine-tRNA ligase |
487-685 |
8.47e-13 |
|
alanine-tRNA ligase
Pssm-ID: 178546 [Multi-domain] Cd Length: 223 Bit Score: 68.57 E-value: 8.47e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 487 GKAQLVFDVTPFYAEMGGQVADHGVIKDAEGQVVANVLDVQHApHGQNLH-------SVETLSPLKVGESYTLEIDKERR 559
Cdd:PLN02961 1 GRIALVLDRTIFHPQGGGQPSDTGRIVISGGDTKFSVQDVRRK-DGVVYHygvfegsNPESASPFEAGDEVTVTVDESRR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 560 AAVVKNHTATHLLHAALHNI--------VGNHALqAGSLneVEFLrfdfthfAQVTKEEL----AEIERQVNEVIWQSLK 627
Cdd:PLN02961 80 KLHSRLHSAGHLLDVCMARVglgplepgKGYHFP-DGPF--VEYK-------GKIPQGELdskqDELEAEANELIAEGGK 149
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 628 VETVETDIATAKEM--GAMALFGEKyGKNVRVVKIGDYSIELCGGTHTQTTSEIGLFKIV 685
Cdd:PLN02961 150 VSAAVLPYDEAAELcgGSLPDYIAK-DSTPRIVKIGDSPGCPCGGTHVADVSEITSVKVT 208
|
|
| PRK12444 |
PRK12444 |
threonyl-tRNA synthetase; Reviewed |
563-689 |
6.05e-05 |
|
threonyl-tRNA synthetase; Reviewed
Pssm-ID: 183530 [Multi-domain] Cd Length: 639 Bit Score: 46.66 E-value: 6.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 563 VKNHTATHLLHAALHNIVGNHALQAGSLNEVEFLrFDFTHFAQVTKEELAEIERQVNEVIWQSLKVETVETDIATAKEmg 642
Cdd:PRK12444 74 IARHSAAHILAQAVKRLYGDVNLGVGPVIENGFY-YDMDLPSSVNVEDLRKIEKEMKKIINENIKIERVEVSREEAAK-- 150
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 643 amaLFGEKY-------------GKNVRVVKIGDYsIELCGGTHTQTTSEIGLFKIVKEEG 689
Cdd:PRK12444 151 ---LFQEMNdrlklelleaipsGESITLYKQGEF-VDLCRGPHLPSTGYLKAFQLTHVSG 206
|
|
| ThrS |
COG0441 |
Threonyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Threonyl-tRNA ... |
598-686 |
1.66e-03 |
|
Threonyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Threonyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440210 [Multi-domain] Cd Length: 639 Bit Score: 41.94 E-value: 1.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545593678 598 FDFTHfaQVTKEELAEIERQVNEVIWQSLKVETVETDIATAKEMgaMALFGEKY----------GKNVRVVKIGDYsIEL 667
Cdd:COG0441 106 FDLER--PFTPEDLEKIEKEMKEIIKEDLPIEREEVSREEAIEL--FKEKGEPYkveliedipeDEEISLYRQGEF-VDL 180
|
90
....*....|....*....
gi 545593678 668 CGGTHTQTTSEIGLFKIVK 686
Cdd:COG0441 181 CRGPHVPSTGKIKAFKLLS 199
|
|
| |
