3-deoxy-D-manno-octulosonic-acid transferase [Cell wall/membrane/envelope biogenesis]; 3-deoxy-D-manno-octulosonic-acid transferase is part of the Pathway/BioSystem: Lipid A biosynthesis
:
Pssm-ID: 441128 [Multi-domain] Cd Length: 424 Bit Score: 512.76 E-value: 1.42e-175
Tetraacyldisaccharide-1-P 4'-kinase (Lipid A 4'-kinase) [Cell wall/membrane/envelope ...
483-838
2.51e-116
Tetraacyldisaccharide-1-P 4'-kinase (Lipid A 4'-kinase) [Cell wall/membrane/envelope biogenesis]; Tetraacyldisaccharide-1-P 4'-kinase (Lipid A 4'-kinase) is part of the Pathway/BioSystem: Lipid A biosynthesis
:
Pssm-ID: 441269 Cd Length: 349 Bit Score: 357.18 E-value: 2.51e-116
3-deoxy-D-manno-octulosonic-acid transferase [Cell wall/membrane/envelope biogenesis]; 3-deoxy-D-manno-octulosonic-acid transferase is part of the Pathway/BioSystem: Lipid A biosynthesis
Pssm-ID: 441128 [Multi-domain] Cd Length: 424 Bit Score: 512.76 E-value: 1.42e-175
Tetraacyldisaccharide-1-P 4'-kinase (Lipid A 4'-kinase) [Cell wall/membrane/envelope ...
483-838
2.51e-116
Tetraacyldisaccharide-1-P 4'-kinase (Lipid A 4'-kinase) [Cell wall/membrane/envelope biogenesis]; Tetraacyldisaccharide-1-P 4'-kinase (Lipid A 4'-kinase) is part of the Pathway/BioSystem: Lipid A biosynthesis
Pssm-ID: 441269 Cd Length: 349 Bit Score: 357.18 E-value: 2.51e-116
Tetraacyldisaccharide-1-P 4'-kinase; This family consists of tetraacyldisaccharide-1-P 4 ...
487-837
3.37e-84
Tetraacyldisaccharide-1-P 4'-kinase; This family consists of tetraacyldisaccharide-1-P 4'-kinase also known as Lipid-A 4'-kinase or Lipid A biosynthesis protein LpxK, EC:2.7.1.130. This enzyme catalyzes the reaction: ATP + 2,3-bis(3-hydroxytetradecanoyl)-D -glucosaminyl-(beta-D-1,6)-2,3-bis(3-hydroxytetradecanoyl)-D-glu cosam inyl beta-phosphate <=> ADP + 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D- glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate. This enzyme is involved in the synthesis of lipid A portion of the bacterial lipopolysaccharide layer (LPS). The family contains a P-loop motif at the N terminus.
Pssm-ID: 460616 Cd Length: 319 Bit Score: 271.75 E-value: 3.37e-84
3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Members of this family transfer ...
51-216
3.71e-69
3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Members of this family transfer activated sugars to a variety of substrates, including glycogen, fructose-6-phosphate and lipopolysaccharides. Members of the family transfer UDP, ADP, GDP or CMP linked sugars. The Glycos_transf_N region is flanked at the N-terminus by a signal peptide and at the C-terminus by Glycos_transf_1 (pfam00534). The eukaryotic glycogen synthases may be distant members of this bacterial family.
Pssm-ID: 461298 Cd Length: 178 Bit Score: 226.21 E-value: 3.71e-69
tetraacyldisaccharide 4'-kinase; Also called lipid-A 4'-kinase. This essential gene encodes an ...
491-841
1.06e-45
tetraacyldisaccharide 4'-kinase; Also called lipid-A 4'-kinase. This essential gene encodes an enzyme in the pathway of lipid A biosynthesis in Gram-negative organisms. A single copy of this protein is found in Gram-negative bacteria. PSI-BLAST converges on this set of apparent orthologs without identifying any other homologs. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]
Pssm-ID: 273216 Cd Length: 311 Bit Score: 166.49 E-value: 1.06e-45
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
87-415
2.96e-05
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.
Pssm-ID: 340831 [Multi-domain] Cd Length: 366 Bit Score: 47.15 E-value: 2.96e-05
3-deoxy-D-manno-octulosonic-acid transferase [Cell wall/membrane/envelope biogenesis]; 3-deoxy-D-manno-octulosonic-acid transferase is part of the Pathway/BioSystem: Lipid A biosynthesis
Pssm-ID: 441128 [Multi-domain] Cd Length: 424 Bit Score: 512.76 E-value: 1.42e-175
Tetraacyldisaccharide-1-P 4'-kinase (Lipid A 4'-kinase) [Cell wall/membrane/envelope ...
483-838
2.51e-116
Tetraacyldisaccharide-1-P 4'-kinase (Lipid A 4'-kinase) [Cell wall/membrane/envelope biogenesis]; Tetraacyldisaccharide-1-P 4'-kinase (Lipid A 4'-kinase) is part of the Pathway/BioSystem: Lipid A biosynthesis
Pssm-ID: 441269 Cd Length: 349 Bit Score: 357.18 E-value: 2.51e-116
Tetraacyldisaccharide-1-P 4'-kinase; This family consists of tetraacyldisaccharide-1-P 4 ...
487-837
3.37e-84
Tetraacyldisaccharide-1-P 4'-kinase; This family consists of tetraacyldisaccharide-1-P 4'-kinase also known as Lipid-A 4'-kinase or Lipid A biosynthesis protein LpxK, EC:2.7.1.130. This enzyme catalyzes the reaction: ATP + 2,3-bis(3-hydroxytetradecanoyl)-D -glucosaminyl-(beta-D-1,6)-2,3-bis(3-hydroxytetradecanoyl)-D-glu cosam inyl beta-phosphate <=> ADP + 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D- glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate. This enzyme is involved in the synthesis of lipid A portion of the bacterial lipopolysaccharide layer (LPS). The family contains a P-loop motif at the N terminus.
Pssm-ID: 460616 Cd Length: 319 Bit Score: 271.75 E-value: 3.37e-84
3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Members of this family transfer ...
51-216
3.71e-69
3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Members of this family transfer activated sugars to a variety of substrates, including glycogen, fructose-6-phosphate and lipopolysaccharides. Members of the family transfer UDP, ADP, GDP or CMP linked sugars. The Glycos_transf_N region is flanked at the N-terminus by a signal peptide and at the C-terminus by Glycos_transf_1 (pfam00534). The eukaryotic glycogen synthases may be distant members of this bacterial family.
Pssm-ID: 461298 Cd Length: 178 Bit Score: 226.21 E-value: 3.71e-69
tetraacyldisaccharide 4'-kinase; Also called lipid-A 4'-kinase. This essential gene encodes an ...
491-841
1.06e-45
tetraacyldisaccharide 4'-kinase; Also called lipid-A 4'-kinase. This essential gene encodes an enzyme in the pathway of lipid A biosynthesis in Gram-negative organisms. A single copy of this protein is found in Gram-negative bacteria. PSI-BLAST converges on this set of apparent orthologs without identifying any other homologs. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]
Pssm-ID: 273216 Cd Length: 311 Bit Score: 166.49 E-value: 1.06e-45
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
87-415
2.96e-05
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.
Pssm-ID: 340831 [Multi-domain] Cd Length: 366 Bit Score: 47.15 E-value: 2.96e-05
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ...
91-415
4.70e-03
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.
Pssm-ID: 340825 [Multi-domain] Cd Length: 391 Bit Score: 40.40 E-value: 4.70e-03
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
200-427
6.01e-03
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.
Pssm-ID: 340836 [Multi-domain] Cd Length: 362 Bit Score: 39.99 E-value: 6.01e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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