|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
8-410 |
1.49e-91 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 280.61 E-value: 1.49e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 8 RWQMIVLVCFITIINYLDRTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGL 87
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 88 ATMGHALTGSWMGLAFMRGIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQFAF 167
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 168 IVAGILAVIAAFIWLIFYkdpkdakrlspeersyiengqekhlnnakkektsvinilkqRNFWGIGISRFLADPAWGTIN 247
Cdd:cd17319 161 IIEGLLGLLLAVLWWFYL-----------------------------------------RQVWGLALGYFGINYALYGLL 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 248 FWVPVFFVETLHFSLKEIAMFVWLPFLMADLGCLASGFVAKFFnergiSLINSRRITFTIGAILMTTIGLVSIIENPYIA 327
Cdd:cd17319 200 TWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRL-----LRGARRLVIIIGLLLAAVGLLLAYLTTSPVVA 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 328 VLLISIGGFSHQLLSTVAATLGADLFKKNEVATAVGMAGACAWSGQLIFNLFIGAFVSIIG-FGPFFIALAVFDLIGAVA 406
Cdd:cd17319 275 VILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGsYTAAFLFLAAVALLAALL 354
|
....
gi 545256359 407 LWIL 410
Cdd:cd17319 355 VLLL 358
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
19-411 |
7.44e-87 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 269.98 E-value: 7.44e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 19 TIINYLDRTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMGHALTGSW 98
Cdd:TIGR00893 3 TVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGAY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 99 MGLAFMRGIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQFAFIVAGILAVIAA 178
Cdd:TIGR00893 83 VSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGIIWG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 179 FIWLIFYKDPKDAKRLSPEERSYIENG-----QEKHLNNAKKeKTSVINILKQRNFWGIGISRFLADPAWGTINFWVPVF 253
Cdd:TIGR00893 163 VLWLKFIPDPPQKAKWLTEEEKYIVVGgllaeQQGKGPSTPK-KYQIKELLKDRRVWGLALGQFLVNIGLGFFLTWFPTY 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 254 FVETLHFSLKEIAMFVWLPFLMADLGCLASGFVAKFFNERGISLINSRRITFTIGAILMTTIGLVSIIENPYIAVLLISI 333
Cdd:TIGR00893 242 LVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFARKTAIIAGLVLSLLMFATNYVNIPYAALALVAL 321
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 545256359 334 GGFSHQlLSTVAATLGADLFKKNEVATAVGMAGACAWSGQLIFNLFIGAFVSIIG-FGPFFIALAVFDLIGAVALWILI 411
Cdd:TIGR00893 322 GFFGLG-AGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGsFAGALMVVAALALIGALSYLLLV 399
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
1-416 |
1.02e-73 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 235.15 E-value: 1.02e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 1 MKYIKHYRWQMIVLVCFITIINYLDRTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFI 80
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 81 CAVIWGLATMGHALTGSWMGLAFMRGIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMF 160
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 161 HSWQFAFIVAGILAVIAAFIwlifykdpkdakrlspeersyiengqekhlnnakkektsvinilkqrNFWGIGISRFLAD 240
Cdd:COG2271 161 FGWRAAFLILGLPGLLLALL-----------------------------------------------RFWLLALAYFLVY 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 241 PAWGTINFWVPVFFVETLHFSLKEIAMFVWLPFLMADLGCLASGFVAKFFNERgislinsRRITFTIGAILMT-TIGLVS 319
Cdd:COG2271 194 FALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRR-------RKLVLAIGLLLAAlALLLLA 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 320 IIENPYIAVLLISIGGFSHQLLSTVAATLGADLFKKNEVATAVGMAGACAWSGQLIFNLFIGAFVSIIGFGPFFIALAVF 399
Cdd:COG2271 267 LLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAAL 346
|
410
....*....|....*..
gi 545256359 400 DLIGAVALWILIKDNKQ 416
Cdd:COG2271 347 ALLAALLALLLLRETRK 363
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
7-412 |
1.34e-52 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 180.85 E-value: 1.34e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 7 YRWQMIVLVCFITIINYLDRTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWG 86
Cdd:COG2223 2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 87 LATMGHALTGSWMGLAFMRGIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQFA 166
Cdd:COG2223 82 IGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 167 FIVAGILAVIAAFIWLIFYKDPKDAKRLSpeersyiengqekhlnnAKKEKTSVINILKQRNFWGIGISRFLADPAWGTI 246
Cdd:COG2223 162 FLILGILLLVVAVLAWLFLRDPPAGAAAA-----------------AKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGF 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 247 NFWVPVFFVETLHFSLKEIAMFVWLPFLMADLGCLASGFVAKFFnergislinSRRITFTIGAILMT--TIGLVSIIENP 324
Cdd:COG2223 225 SSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRI---------GGRRVLLIVFALMAlgLLLLALALGSL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 325 YIAVLLISIGGFSHQLLSTVAATLGADLFKKNEVATAVGMAGACAWSGQLIFNLFIGAFVSIIG-FGPFFIALAVFDLIG 403
Cdd:COG2223 296 WLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVA 375
|
....*....
gi 545256359 404 AVALWILIK 412
Cdd:COG2223 376 LVLTLLLYR 384
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-373 |
5.66e-41 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 148.97 E-value: 5.66e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 1 MKYIKHYRWQMIVLVCFITIINYLDRTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFI 80
Cdd:COG2814 1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 81 CAVIWGLATMGHALTGSWMGLAFMRGIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMF 160
Cdd:COG2814 81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 161 HSWQFAFIVAGILAVIAAFIWLIFYKDPKDAKRlspeersyiengqekhlnnaKKEKTSVINILKQRNFWGIGISRFLAD 240
Cdd:COG2814 161 FGWRWVFLVNAVLALLALLLLLRLLPESRPAAR--------------------ARLRGSLRELLRRPRLLLLLLLAFLLG 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 241 PAWGTINFWVPVFFVETLHFSLKEIAMFVWLPFLMADLGCLASGFVAKFFnergislinSRRITFTIGAILMT-TIGLVS 319
Cdd:COG2814 221 FGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF---------GRRRLLLIGLLLLAlGLLLLA 291
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 545256359 320 IIENPYIAVLLISIGGFSHQLLSTVAATLGADLFKKNEVATAVGMAGACAWSGQ 373
Cdd:COG2814 292 LAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
23-393 |
7.55e-39 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 143.67 E-value: 7.55e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 23 YLDRTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMGHALTGSWMGLA 102
Cdd:TIGR00881 8 YLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 103 FMRGIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLI-AWCIMFHSWQFAFIVAGILAVIAAFIW 181
Cdd:TIGR00881 88 ALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVlFGIAELYSWHWVFIVPGIIAIIVSLIC 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 182 LIFYKDPKDAKRLSPEERSYIE---NGQEKHLNNAKKEKTSVINILKQRNFWGIGISR-FLADPAWGtINFWVPVFFVET 257
Cdd:TIGR00881 168 FLLLRDSPQSCGLPPAEEMPNEepdGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYvFVYVVRTG-ILDWSPLYLTQE 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 258 LHFSLKEIAMFVWLPFLMADLGCLASGFVA-KFFNERGISLINSRRITFTIGAILMTTIGLVSiieNPYIAVLLISIGGF 336
Cdd:TIGR00881 247 KGFSKEKASWAFTLYELGGLVGTLLAGWLSdKLFNGRRGPLAVFFMALIIVSLLVYWLNPAAN---PLMDLICLFALGFL 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 545256359 337 SH--QLLSTVAAtlgADLFKKNEVATAVGMAGACAWSGQLIFNLFIGAFVSIIGFGPFF 393
Cdd:TIGR00881 324 VYgpQMLIGVIA---SELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFGWAGAF 379
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
15-376 |
5.50e-36 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 135.24 E-value: 5.50e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 15 VCFITIINYLDRTALGVAAP-TIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMGHA 93
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 94 LTGSWMGLAFMRGIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQFAFIVAGIL 173
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 174 AVIAAFIWLiFYKDPKDAKRLSPEERsyiengqekhlnnAKKEKTSVINILKQRNFWGIGISRFLADPAWGTINFWVPVf 253
Cdd:pfam07690 161 SLLAAVLLL-LPRPPPESKRPKPAEE-------------ARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPL- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 254 FVETLHFSLKEIAMFVWLPFLMADLGCLASGFVAKFFNERgislinsRRITFTIGAILMTTIGLV--SIIENPYIAVLLI 331
Cdd:pfam07690 226 YQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRR-------RRLLLALLLLILAALGLLllSLTLSSLWLLLAL 298
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 545256359 332 SIGGFSHQLLSTVAATLGADLFKKNEVATAVGMAGACAWSGQLIF 376
Cdd:pfam07690 299 LLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
15-408 |
1.79e-32 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 126.39 E-value: 1.79e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 15 VCFITIINYLDRTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMGHAL 94
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 95 TGSWMGLAFMRGIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFH--SWQFAFIVAGI 172
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 173 LAVIAAFIWLIFYKDPKDAKRLSPEERSYiengqekhlnnaKKEKTSVINILKQRNFWGIGISRFLADPAWGTINFWVPV 252
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASS------------KSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 253 FFVETLHFSLKEIAMFVWLPFLMADLGCLASGFVAKFFnergislINSRRITFTIGAILMTTIGLVSIIENPYIAVLLIS 332
Cdd:cd06174 229 FLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRL-------IGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLL 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 545256359 333 IGGFSHQLLSTVAATLGADLFKKNEVATAVGMAGACAWSGQLIFNLFIGAFVSI-IGFGPFFIALAVFDLIGAVALW 408
Cdd:cd06174 302 LLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAtFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
8-410 |
4.19e-32 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 126.20 E-value: 4.19e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 8 RWQMIVLVCFITIINYLDRTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFID----NIGLKLGFFICAV 83
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDrsnpKRFLAIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 84 I-WGLATMGHALTGSWMgLAFMRGIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMF-- 160
Cdd:cd17345 81 InILIGFVPSATSSVGL-MFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIfg 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 161 -HSWQFAFIVAGILAVIAAFIWLIFYKDPKDAKRLSPEERSYIENGQEKHLNNAKKEKTS----VINILKQRNFWGIGIS 235
Cdd:cd17345 160 dGWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIEEYKGDYPEEADGEEEEQELSAweifVKYVLKNKLLWYIAIA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 236 R-FLADPAWGTINfWVPVFFVETLHFSLKEIAMFVWLPFLMADLGCLASGFVA-KFFnergisliNSRRITFTIGAILMT 313
Cdd:cd17345 240 NvFVYLVRYGILD-WAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSdKLF--------KGRRAPTGIIFMILV 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 314 TIGLVSIIENPYIAVLLISIGG-----FSHQLLSTVAATlgaDLFKKNEVATAVGMAGACAWSGQLIF-NLFIGAFVSII 387
Cdd:cd17345 311 IVALIVYWLAPNVLVDLIALIAlgfliYGPVMLIGLQAL---ELVPKKAAGTAAGLTGLFGYLGGSVLaTALIGIIVDHF 387
|
410 420
....*....|....*....|...
gi 545256359 388 GFGPFFIALAVFDLIGAVALWIL 410
Cdd:cd17345 388 GWNGGFIVLLASCILAIIFLALV 410
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
34-411 |
6.68e-32 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 124.61 E-value: 6.68e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 34 PTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMGHALTGSWMGLAFMRGIMGVSEA 113
Cdd:cd17325 20 PLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 114 SAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQFAFIVAGILAVIAAFIWLIFYKDPKdakr 193
Cdd:cd17325 100 AVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPR---- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 194 lspeersyieNGQEKHLNNAKKEKTSVINILKQRNFWGIGISRFLADPAWGTINFWVPVFFVETLHFSLKEIAMFvwlpF 273
Cdd:cd17325 176 ----------PPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLL----F 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 274 LMADLGCLASGFVAKFFNERGislinSRRITFTIGAILMT-TIGLVSIIENPYIAVLLISIGGFSHQLLSTVAATLGADL 352
Cdd:cd17325 242 GAQGLASALSQPPAGKLSDRI-----GRKPLILIGLLLSAvALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADI 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 545256359 353 FKKNEVATAVGMAGACAWSGQLIFNLFIGAFVSIIGFGPFFIALAVFDLIGAVALWILI 411
Cdd:cd17325 317 VPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
8-407 |
3.76e-30 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 119.69 E-value: 3.76e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 8 RWQMIVLVCFITIINYLDRTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGL 87
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 88 ATMGHALTGSWMGLAFMRGIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQFAF 167
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 168 IVAGILAVIAAFIWLIFYKDpkdakrlspeERSYIengqekhlnnakkektsvinilkqrnfWGIGISRFLADPAWGTIN 247
Cdd:cd17312 161 LVPGIVGLVVAIILFFFLRD----------SPPYV---------------------------WVLSLAYAFVYIVRYACL 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 248 FWVPVFFVETLHFSLKEIAMFVWLPFLMADLGCLASGFVA-KFFNERgislinsRRITFTIGAILMTTiGLVSIIENP-- 324
Cdd:cd17312 204 DWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSdKLFGGR-------RAPIAVIYMLLMTL-SLALFWFFPhn 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 325 --YIAVLLISIGGFSHQLLSTVAATLGADLFKKNEVATAVGMAGACAWSGQLIFNLFIGAFVSIIGFGPFFIALAVFDLI 402
Cdd:cd17312 276 klLSIVLLFLIGFFVGGPINLIGGAAAQDIGRKEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALL 355
|
....*
gi 545256359 403 GAVAL 407
Cdd:cd17312 356 SVLLL 360
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
9-398 |
9.76e-28 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 113.50 E-value: 9.76e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 9 WQMIVLVCFITIINYLDRTALGVAAPTIMS-DLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGL 87
Cdd:cd17327 4 LFILPLLCILYFLQYLDKSNISNAAVMGMKeDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 88 ATMGHALTGSWMGLAFMRGIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLApPLIAWCIM-------F 160
Cdd:cd17327 84 LTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFG-GLLAYGVFkilgvggL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 161 HSWQFAFIVAGILAVI-AAFIWLIFYKDPKDAKRLSPEERSY----IENGQEKhLNNAKKEKTSVINILKQRNFWGIGIS 235
Cdd:cd17327 163 AGWRWLFIIEGLITIIiGLVIFFWLPDNPSKAWFLTEEEKELaverLRANQTG-KGDQKFKWKQIKEAFKDPRTWLLFLF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 236 RFLADPAWGTINFWVPVfFVETLHFSLKEIAMFVWLPFLMADLGCLASGFVAKFFNERGIslinsrritFTIGAILMTTI 315
Cdd:cd17327 242 FFCSQITNNGISNFLPL-ILKSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGL---------FAIFACVLALV 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 316 GLVSIIENP------YIAVLLISIGGFSHQLLSTVAATLGADLFKKnEVATAVGMAGAC---AWSGQLIFNL----FIGA 382
Cdd:cd17327 312 GSIILLAAPnppgayFAAYILGGGSYAGFPILLSWISSNCAGYTKR-ATVLAIMLIFYNvgnIVAPQIFRAGdaprYIPG 390
|
410
....*....|....*.
gi 545256359 383 FVSIIGFGPFFIALAV 398
Cdd:cd17327 391 NIALLVCACVSIVLSV 406
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
28-408 |
1.95e-27 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 112.33 E-value: 1.95e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 28 ALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMGHALTGSWMGLAFMRGI 107
Cdd:cd17475 14 GIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 108 MGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQFAFIVAGILAVIAAFIWLIFYKD 187
Cdd:cd17475 94 VGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYRE 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 188 PKDAKRLSPeersyiengqekhlnNAKKEKTSVINILKQRNFWGIGISRF-LADPAWGTINFWVpVFFVETLHFSLKEIA 266
Cdd:cd17475 174 PPAASAATE---------------SASTLLRSLKEVLRNRDVWLIAIAGAlLVAPQFALLTFLL-LFLHDHLGLSVVAAG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 267 MFVWLPFLMADLGCLASGFVAK--FFNERGISLinsrRITFTIGAILMTTIGLVSIIENPYIAVLLISIGGFSHQLLSTV 344
Cdd:cd17475 238 ALLAVAQLGGALGRIGLGRVSDrvFGGRRRPVL----VITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGL 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 545256359 345 AATLGADLFKKNEVATAVGMAGACAWSGQLIFNLFIGAFV-SIIGFGPFFIALAVFDLIGAVALW 408
Cdd:cd17475 314 YLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVdATHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
13-338 |
7.12e-25 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 104.94 E-value: 7.12e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 13 VLVCFI-TIINYLDRTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLAT-- 89
Cdd:cd17380 1 VILLFLaTCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATll 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 90 MGHALTGSWMGLAFMRGIMGVSEASAIPAGVKTASTWFPAKER----GIATGVFNMGTSFGAMLAPPLIAWcimfHSWQF 165
Cdd:cd17380 81 TPLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERsravSIVTAGSYLGTLLGGLIGPLLLEY----YGWPS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 166 AFIVAGILAVIAAFIWLIFYkdpkdakrlspeersyiengqekhlnnakkektsvinilkqRNFWGIGISRFLADPAWGT 245
Cdd:cd17380 157 VFYFFGLLGLLWALVWLIYL-----------------------------------------PPVWAIIVAHFCMNWGFYI 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 246 INFWVPVFFVETLhFSLKEIAMFVWLPFLMADLGCLASGFVAKFFNERGISLINSRRITFTIG----AILMTtigLVSII 321
Cdd:cd17380 196 LLSWLPTYFHEVL-VPLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGWTVTSVRKLMQSIGflgpALFLL---LLSHT 271
|
330 340
....*....|....*....|.
gi 545256359 322 ENPYIAVLLISIG----GFSH 338
Cdd:cd17380 272 DSFSLALLCMSVAlglsAFSS 292
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
27-413 |
5.19e-24 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 103.03 E-value: 5.19e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 27 TALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMGHALTGSWMGLAFMRG 106
Cdd:COG2807 35 TSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTA 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 107 IMGVSEASAIPAGVKTASTWFPAKeRGIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQFAFIVAGILAVIAAFIWLIFYK 186
Cdd:COG2807 115 LIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLR 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 187 DPKDAKRLSPEERsyiengqekhlnnakkektSVINILKQRNFWGIGISRFLADPAWGTINFWVPVFFVEtLHFSLKEIA 266
Cdd:COG2807 194 RRPAAAAAAPAAA-------------------SLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAG 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 267 mfvWLPFLMAdLGCLASGFVAKFFNERgislINSRRITFTIGAiLMTTIGLVSII----ENPYIAVLLISIGGFShqlLS 342
Cdd:COG2807 254 ---LLLSLFQ-LAGIPGSLLVPLLADR----LGDRRPLLLLLG-LLGLAGLLGLLlapgSLPWLWAVLLGLGQGG---LF 321
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 545256359 343 TVAATLGADLFK-KNEVATAVGMAGACAWSGQLIFNLFIGAFVSIIG-FGPFFIALAVFDLIGAVALWILIKD 413
Cdd:COG2807 322 PLALTLIGLRARtPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGsWTAALLLLAALAVLMLVAGLLAGRP 394
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
8-417 |
1.78e-23 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 101.08 E-value: 1.78e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 8 RWQMIVLVCFITIINYLDRTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGL 87
Cdd:COG0738 6 YRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 88 ATMGHALTGSWMGLAFMRGIMGVSeASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFH---SWQ 164
Cdd:COG0738 86 GLLLFALAPSYPLLLLALFLLGLG-LGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGlslSWH 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 165 FAFIVAGILAVIAAfIWLIFYKDPKDakrlspeersyiengqEKHLNNAKKEKTSVINILKQRNFWGIGISRFLADPAWG 244
Cdd:COG0738 165 LPYLILAVLLLLLA-LLFLRSKLPEI----------------EEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEG 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 245 TINFWVPVFFVETLHFSLKEIAMFVWLPFLMADLGCLASGFVAKFFnergislinSRRITFTIGAILMTT-IGLVSIIEN 323
Cdd:COG0738 228 AIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF---------GPVRLLRLSALLAAVgLLLALLAPG 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 324 PYIAVLLISIGGFSHQLLSTVAATLGADLFKKNeVATAVGMAGACAWSGQLIFNLFIGAFVSIIGFGPFFIALAVFDLIG 403
Cdd:COG0738 299 PWLALIGLALVGLGLSLMFPTIFSLALDGLGKR-TAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLI 377
|
410
....*....|....
gi 545256359 404 AVALWILIKDNKQT 417
Cdd:COG0738 378 LLLALALKRKRRKK 391
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
14-336 |
4.68e-23 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 100.39 E-value: 4.68e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 14 LVCFITIINYLDRTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMGHA 93
Cdd:cd17328 3 VLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 94 LTGSWMGLAFMRGIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFH-SWQFAFIVAGI 172
Cdd:cd17328 83 FAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 173 LAVIAAFIWLIFYKDPkdaKRLSPEERSYIENGQEKHLNNAKkektsviNILKQRNFWGIGISRFLADPAWGTINFWVPV 252
Cdd:cd17328 163 LGVLLAILLLLFVREP---PRGAAEGGVMAKSTATSFLADLK-------ALAKNPSFILSTLGFTAVSFVTGALAFWAPT 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 253 FFVETL---HFSLKEIAMFVWLPFLMAD-LGCLASGFVAKFFNERGIslinsrRITFTIGAILM------TTIGLVSIIE 322
Cdd:cd17328 233 FFLRAFgvgDLSSADVGLIFGAITCIAGvLGVLLGGILADRLRRKTP------RADPLVCAVGLlaaapfLFLALVLALS 306
|
330
....*....|....
gi 545256359 323 NPYIAVLLISIGGF 336
Cdd:cd17328 307 NLLLAWVLLFLGEF 320
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
8-184 |
3.16e-22 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 96.03 E-value: 3.16e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 8 RWQMIVLVCFITIINYLDRTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGL 87
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 88 ATMGHALTGSWMGLAFMRGIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQFAF 167
Cdd:COG0477 92 ASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171
|
170
....*....|....*..
gi 545256359 168 IVAGILAVIAAFIWLIF 184
Cdd:COG0477 172 LINAPLGLLALVLRLRL 188
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
12-410 |
7.40e-22 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 96.49 E-value: 7.40e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 12 IVLVCFITIINYLDRTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMG 91
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 92 HALTGSWMGLAFMRGIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLApPLIAWCIMFHSWQFAFIVAG 171
Cdd:cd17474 81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVG-PLLGGLLAAISWRYPFFLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 172 ILAVIAAFIWLIFYKDPKDAKRLSPeersyiengqekhlnnaKKEKTSVINILKQRNFWGIGISRFLADPAWGTINFWVP 251
Cdd:cd17474 160 ALIPVAFLAILFLLPEPKEKAKSSS-----------------ATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLP 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 252 VFFVETLHFSLKEIAMFVwlpFLMADLGCLASGFVAKFFNERgisliNSRRITFTIGAILMT-TIGLVSIIENPYIAVLL 330
Cdd:cd17474 223 FLLELLYGISPIIIGLLF---AGWSVLLALGSLFVGRLLKKR-----FGARRILVIGLLLYAlSLLLLGFVPSLALLLIA 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 331 ISIGGFSHQLLSTVAATLGADLFKKNEVATAVGMAGACAWSGQLIFNLFIGAFVSIIGFGPFFIALAVFDLIGAVALWIL 410
Cdd:cd17474 295 IVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
43-338 |
1.15e-21 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 96.15 E-value: 1.15e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 43 SKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMGH--ALTGSWMGLAFMRGIMGVSEASAIPAGV 120
Cdd:cd17318 54 SEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTplAARGGYGALIVLRILQGLAQGVTFPAMH 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 121 KTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQFAFIVAGILAVIAAFIWLIFYkdpkdakrlspeers 200
Cdd:cd17318 134 ALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV--------------- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 201 yiengqekhlnnakkektsvinilkqRNFWGIGISRFLADPAWGTINFWVPVFFVETLHFSLKEIAMFVWLPFLMADLGC 280
Cdd:cd17318 199 --------------------------LPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICS 252
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 545256359 281 LASGFVAKFFNERGI-SLINSRRITFTIGAILMTT--IGLVSIIENPYIAVLLISIGGFSH 338
Cdd:cd17318 253 IVGGYLADWLRSRGIlSTTTVRKLFTSIGFLGPGVflIALGYLGSNATLAVVFLTLSVGLS 313
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
34-408 |
2.03e-21 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 94.92 E-value: 2.03e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 34 PTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMGHALTGSWMGLAFMRGIMGVSEA 113
Cdd:cd17324 23 PDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 114 SAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQFAFIVAGILAVIAAF-IWLIFYKDPKDAK 192
Cdd:cd17324 103 GFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALlLWRLLPSLPPKKP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 193 RLSPEERSYIEngqekhlnnakkektsvinILKQRNFWGIGISRFLADPAWGTINFWVPVFFVETLHFSlkeiAMFVWLP 272
Cdd:cd17324 183 GSLGLLSSLLL-------------------LLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFS----SSAIIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 273 FLMADLGCLASGFVAKFFNERGisliNSRRITFTIGAILMTTIGLVSIIENPYIAVLLISIGGFSHQLLSTVAATLGADL 352
Cdd:cd17324 240 LLLFGVAGVVGSPLAGRLADRG----GRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRL 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 545256359 353 FKKNeVATAVGMAGACAWSGQLIFNLFIGAFVSIIGFGPFFIALAVFDLIGAVALW 408
Cdd:cd17324 316 APEA-RGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
8-410 |
4.12e-20 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 91.52 E-value: 4.12e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 8 RWQMI---VLVCFITIINYldrtALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVI 84
Cdd:cd17353 2 RWLVLlgaVLMHLILGYQY----AWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGIL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 85 W--GLATMGHAlTGSWMGLAFMRGIMGVSEASAIPAGVKTASTWFPAKeRGIATGVFNMGTSFGAMLAPPLIAWCIMFHS 162
Cdd:cd17353 78 FglGFILSAFA-ISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDK-RGLATGIVIAGFGLGSLIFSPLIAYLINTVG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 163 WQFAFIVAGILAVIAAFIWLIFYKDPkdAKRLSPEERSYIENGQEKHLNNAkkektSVINILKQRNFWGIGISRFL-ADP 241
Cdd:cd17353 156 VPTTFLILGIIFLIIIVIGAFLIRDP--PKGWVPPGVDPLANNAENSPRDY-----TPREMLRTPTFWLLWLMFFLnATA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 242 AWGTINFWVPvFFVETLHFSLKEIAMFVWLPFLMADLGCLASGFVAKFfnergISLINSRRITFTIGAILMttIGLVSII 321
Cdd:cd17353 229 GLMLIGQAKP-IGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDK-----IGRKNTLSIAFLIQGVAM--FLLPFIG 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 322 ENPYIAVLLISIGGFSHQLLSTVAATLGADLFKKNEVATAVGMAgACAWSGQLIFNLFIGAFVSI-IGFGPFFIALAVFD 400
Cdd:cd17353 301 SVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLL-YTAKGVGGLIGPIIAAYVLYtGGYNAAFIIAAALS 379
|
410
....*....|
gi 545256359 401 LIGAVALWIL 410
Cdd:cd17353 380 LVALALALLL 389
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
6-388 |
1.94e-19 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 89.72 E-value: 1.94e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 6 HYRWQMIVLVCFITIINYLDRTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIW 85
Cdd:TIGR00895 13 RYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 86 GLATMGHALTGSWMGLAFMRGIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQF 165
Cdd:TIGR00895 93 SVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRS 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 166 AFIVAGILAVIAA----------FIWLIFYKDPKDAKRLSPEERSYIENGQEKHLNNAKKE--KTSVINILKQ----RNF 229
Cdd:TIGR00895 173 LFYVGGIAPLLLLlllmrflpesIDFLVSKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQgtKRSVFKALFQgktaRIT 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 230 WGIGISRFLADPAWGTINFWVPVFFVETlHFSLKEIAMFVWLPFLMADLGCLASGFVAKFFNERGISLInsrritFTIGA 309
Cdd:TIGR00895 253 VLLWLLYFMLLVGVYFLTNWLPKLMVEL-GFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALL------LLLGA 325
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 545256359 310 ILMTTIGlvSIIENPYIAVLLISIGGFSHQLLSTVAATLGADLFKKNEVATAVGMAgacawsgqlifnLFIGAFVSIIG 388
Cdd:TIGR00895 326 VFAVLVG--STLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWA------------IGIGRLGAIIG 390
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
12-364 |
4.70e-18 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 85.32 E-value: 4.70e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 12 IVLVCFITIinyLDRTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMG 91
Cdd:cd17503 1 LLLGAFMAI---LDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 92 HALTGSWMGLAFMRGIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQFAFIVAG 171
Cdd:cd17503 78 CGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 172 ILAVIAAFIwlifykdpkdakrlspeersyiengqekhlnnakkekTSVIN--ILKQRNFWGIGISRFLADPAWGTINFW 249
Cdd:cd17503 158 PIGILALLL-------------------------------------APLLDlrLFKDRNFTLGLLLSFLLGLGLFGAMFL 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 250 VPVFFVETLHFSLKEIAMFVwlpFLMADLGCLASGFVAKFFNERGIslinsrRITFTIGAILMTT----IGLVSIIENPY 325
Cdd:cd17503 201 LPLYLQNVLGYSAFESGLVL---APGGLASAILSPLVGRLLDKFGP------RLLLLAGLLLLALgtllLAFLTPDTSLW 271
|
330 340 350
....*....|....*....|....*....|....*....
gi 545256359 326 IAVLLISIGGFSHQLLSTVAATLGADLFKKNEVATAVGM 364
Cdd:cd17503 272 LIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATAL 310
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
12-409 |
1.09e-17 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 83.81 E-value: 1.09e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 12 IVLVCFITIINYLDRTALGVAAPTIMS--DLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLAT 89
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAefSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 90 MGHALTGSWMGLAFMRGIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHS----WQF 165
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSgdwgWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 166 AFIVAGILAVIAAFIWlifykdpkdakrlspeersyiengqekhlnnakkektsvinilkqRNFWGIGISRFLADPAWGT 245
Cdd:cd17316 161 LFLIGALPALLALLLR---------------------------------------------RRTLLLILLWFFISFGYYG 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 246 INFWVPVFFVETLHFSLKEIAMFVWLPFLMADLGCLASGFVAKFFNERGISLInsrritFTIGAILMTTIGLVSIIENPY 325
Cdd:cd17316 196 LTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVI------GLILSGILALPLFYLLSGSPT 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 326 IAVLLISIGGFSHQLLSTVAATLGADLFKKNEVATAVGMAGACAWSGQLIFNLFIGAFVSIIGFGPFFIALAVFDLIGAV 405
Cdd:cd17316 270 LLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVAL 349
|
....
gi 545256359 406 ALWI 409
Cdd:cd17316 350 IVAL 353
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
24-410 |
1.19e-17 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 83.76 E-value: 1.19e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 24 LDRTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMGHALTGSWMGLAF 103
Cdd:cd17321 10 LDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 104 MRGIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQFAFIVAGILAVIAAFIwli 183
Cdd:cd17321 90 ARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLL--- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 184 fykdpkdakrlspeersyiengqekhlnnakkektsvinilkQRNFWGIGISRFLADPAWGTINFWVPVFFVETLHFSLK 263
Cdd:cd17321 167 ------------------------------------------ARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPL 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 264 EIAMFVWLPFLMADLGCLASGFVAKFFNERGISLINSrrITFTIGAILMTTIGLVSIIENPYIAVLLISIGGFSHQLLST 343
Cdd:cd17321 205 QAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGL--LLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLT 282
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 545256359 344 VAATLGADlfkKNEVATAVGMAGAC---------AWSGQLIFNLFIGAFVSIIGFGPFFIALAVFDLIGAVALWIL 410
Cdd:cd17321 283 NAALSSVP---KEKAGAASGILNTArqlggalgvALLGALLTAGLSANLGDSGVAALLSAAAAAFAAGFHLAFLVA 355
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
29-413 |
1.14e-16 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 81.19 E-value: 1.14e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 29 LGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMGHALTGSWMGLAFMRGIM 108
Cdd:cd17371 18 LGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 109 GVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFG----AMLAPPLIAWCIMFHSWQFAFIVAGILAVIAAFIWLiF 184
Cdd:cd17371 98 GLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGwllaTLLAALLFPLLPPEIAWRVLFLLGALPALLVLFIRR-F 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 185 YKDPkdakrlspeersyiENGQEKHLNNAKKEKTSVINILKQRNFWGIGISRFL----ADPAWGTINFWVPVFFVETLHF 260
Cdd:cd17371 177 VKEP--------------PQWQAARAARRHFADRPSLRELFSPPLLRTTLLASLlatgALGGYYGITTWLPSYLTGERGL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 261 SLKEIAMFVWLPFLMADLGCLASGFVAKFFnergislinSRRITFTIGAILmTTIGLVSII---ENPYIAVLLISIGGFS 337
Cdd:cd17371 243 SFEGSAGYLVVTILGGFLGYLAGGFLADRI---------GRRNNFALFALG-SAISILLYFflpLSPTLILILGFPLGFF 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 545256359 338 HQLLSTVAATLGADLFKKNEVATAVGMAGACAWSGQLIFNLFIGAFVSIIGFGPFFIALAVFDLIGAVALWILIKD 413
Cdd:cd17371 313 ASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALLLPE 388
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
12-185 |
1.85e-16 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 80.32 E-value: 1.85e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 12 IVLVCFITIINYLDRTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMG 91
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 92 HALTGSWMGLAFMRGIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQFAFIVAG 171
Cdd:cd17365 81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGG 160
|
170 180
....*....|....*....|.
gi 545256359 172 ILAVIAA-------FIWLIFY 185
Cdd:cd17365 161 VPPLILLpllrgtlLLWVTFF 181
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
24-188 |
4.07e-16 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 80.12 E-value: 4.07e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 24 LDRTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMGHALTGSWMGLAF 103
Cdd:TIGR00711 16 LDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMII 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 104 MRGIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQFAFIV---AGILAVIAAFI 180
Cdd:TIGR00711 96 FRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLInvpIGIIVVVVAFF 175
|
....*...
gi 545256359 181 WLIFYKDP 188
Cdd:TIGR00711 176 ILPRDKPA 183
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
12-410 |
2.07e-15 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 77.31 E-value: 2.07e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 12 IVLVCFIT-IINYLDRTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATM 90
Cdd:cd17355 4 VLAVTFLIlILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 91 GHALTGSWMGLAFMRGIMGVSEASAIPAGV-KTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQFAFIV 169
Cdd:cd17355 84 LLALATSLWQLYLLWGLLGGGGAGTLAAVAfATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 170 -AGILAVIAAFIWLIFYKDPKDAKRLSPEERSYIENGqekhlnnakkekTSVINILKQRNFWGIGISRFLADPAWGTINF 248
Cdd:cd17355 164 lALLALLVLVPVLLLLRRRPADLALRAYDDASPASPG------------STLKEALRSASFWLLALAFFLCGFAVVGLIV 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 249 WVPVFFVEtLHFSLKEIAMFVWLPFLMADLGCLASGFVAKffnergisLINSRRITFTIGAILMTTIGLVSIIENPYIAV 328
Cdd:cd17355 232 HLVPYLAD-RGISPAAAAVALALIGLFNIVGRLLSGWLGD--------RYSPRRLLAASYALRALGLALLLLLPFPPLAL 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 329 LLISIG-GFSHQLLSTVAATLGADLFKKNEVATAVGMAGACAWSGQLIFNLFIGAFVSIIG-FGPFFIALAVFDLIGAVA 406
Cdd:cd17355 303 LLFAALfGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGsYTAAWALAVALGLIAALL 382
|
....
gi 545256359 407 LWIL 410
Cdd:cd17355 383 VLPI 386
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
15-410 |
2.35e-15 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 76.86 E-value: 2.35e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 15 VCFITIINYLDRTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMGHAL 94
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 95 TGSWMGLAFMRGIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQFAFIVAGILA 174
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 175 VIA-AFIWLIFYKDPKDAKRLSPEERSYIEngqekhlnnakkektsviniLKQRNFWGIGISRFLADPAWGTINFWVPVF 253
Cdd:cd17489 161 LLAlLLVFLVKDPPPVAAEEAEAGTRAFRR--------------------LVEKKVLPPALILFLASIAYGAISTFLPLY 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 254 FVETLH------FSLKEIAMFVWLPFLmadlgclasgfvAKFFNERGislinsrRITFTIGAILMTTIGLVSIIENPYIA 327
Cdd:cd17489 221 AAERGIsnaglfFTVYAIALLLSRPFS------------GKLSDRKG-------PKTVIIPGLLLLALGLLLLSFAGSPW 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 328 VLLIS--IGGFSHQLLSTVAATLGADLFKKNEVATAVGMAGACAWSGQLIFNLFIGAFVSIIGFGPFFIALAVFDLIGAV 405
Cdd:cd17489 282 MLLLAavLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALV 361
|
....*
gi 545256359 406 ALWIL 410
Cdd:cd17489 362 LYIFL 366
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
2-370 |
3.38e-15 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 77.39 E-value: 3.38e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 2 KYIKHYrwqMIVLVCFITIinYLDRTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLK--LGFF 79
Cdd:PRK09556 26 PFMQSY---LVVFIGYLTM--YLIRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVGKTLVGYYADGKNTKqfLPFL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 80 -----ICAVIWGLATMGhalTGSWMGLAF-MRGIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPL 153
Cdd:PRK09556 101 lilsaICMLGFGASLGS---GSVSLGLMIaLWALSGFFQSTGGPCSYSTITRWTPRRKRGRFLGFWNISHNLGGAGAGGV 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 154 IAW--CIMFH-SWQFAFIVAGILAVIAAFIWLIFYKDPKDAKRLSPEERSYIENGQEKHLNNAKKEKTS----VINILKQ 226
Cdd:PRK09556 178 ALWgaNYFFDgHVIGMFIFPSIIALIIGFIGLRYGSDSPEELGWGKAEEIFGEPISEEDKETESTDMTKwqifVEYVLKN 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 227 RNFWGIGISRFLADPAWGTINFWVPVFFVETLHFSLKEIAMFVWLPFLMADLGCLASGFVAkffnergiSLINSRRITFT 306
Cdd:PRK09556 258 PVIWLLCFANIFLYIVRIGIDNWSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLS--------DLANGRRALVA 329
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 545256359 307 IGAILMT--TIGLVSIIENPYIAVLLISIGG---FSHQLLSTVAATlgaDLFKKNEVATAVGMAGACAW 370
Cdd:PRK09556 330 CIALALIifTLGVYQHATSEYMYLASLFALGflvFGPQLLIGVAAV---GFVPKKAIGVANGIKGTFAY 395
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
50-311 |
5.96e-15 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 76.32 E-value: 5.96e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 50 IVSVFQLAYTIGQPIMGFFIDNIGLK----LGFFICAVIWGLATMGHALTGSWmgLAFMRGIMGVSEASAIPAGVKTAST 125
Cdd:TIGR00894 81 ILSSHFYGQIIIQIPVGYLAGKYVFKwsigIGMFLSSVISIVIPWAAGGGIAL--VVFCRVIQGLAQGSVSPATHKIIVK 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 126 WFPAKERGIATGVFNMGTSFGAMLAPPLIAW-CIMFHSWQFAFIVAGILAVIAAFIWLIF-YKDPKDAKRLSPEERSYIE 203
Cdd:TIGR00894 159 WAPPKERSRLLGMSTSGFQLGTFIFLPISGWlCESWGGWPMIFYVFGIVGCAWSLLWFVFpADDPSIHPCISKFEKKYIN 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 204 NGQEKHlNNAKKEKTSVINILKQRNFWGIGISRFLADPAWGTINFWVPVFFVETLHFSLKEIAMFVWLPFLMADLGCLAS 283
Cdd:TIGR00894 239 SSLQGQ-KGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFA 317
|
250 260
....*....|....*....|....*....
gi 545256359 284 GFVAKFFNERGI-SLINSRRITFTIGAIL 311
Cdd:TIGR00894 318 GYLADFLKSSKTlSLTAARKIFNGIGGLG 346
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
27-407 |
3.62e-13 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 70.36 E-value: 3.62e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 27 TALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMGHALTGS----WMGLA 102
Cdd:cd17341 16 FLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVSsywgLLVLG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 103 FMRGIMGVSEASAIPagvkTASTWFPAKERG----IATGVFNMGTSFGAMLAPPLIAWCIM---FHSWQFAFIVAGILAV 175
Cdd:cd17341 96 FLLGFAGANFASGQP----WASFWFPKEKIGgaagGIAGAGNMGVAVSQLLAPLIAGAIVFdggFVGWRNAFFVPGILLA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 176 IAAFIWLIFYKDPKDAKRLSPEERSyiengqekhlnnakkektSVINILKQRNFWGIGISRFLADPAWGTINFWVPVFFV 255
Cdd:cd17341 172 IAAVLVLLFGDDLPTGKASALEFLK------------------VQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFK 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 256 ETLHFSLKEIAMFVWLPFLMADLGCLASGFVAKFFNERGISLINSrrITFTIGAILMTTIGLVSIIENPyIAVLLISIGG 335
Cdd:cd17341 234 TRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLF--IVMTIGAALLSLSLPTSGTNLV-LFLALFVALG 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 545256359 336 FSHQLLSTVAATLGADLFKKnEVATAVGMAGACAWSGQLIFNLFIGAFVSIIGFGPFFIALAVFDLIGAVAL 407
Cdd:cd17341 311 LGAGAGNGSVFRMVPFIFRR-ELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTLL 381
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
23-410 |
3.69e-13 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 70.89 E-value: 3.69e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 23 YLDRTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDN--------IGLkLGFFICAVIWGLATMGHAL 94
Cdd:PRK11663 36 YFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRsnaryfmgIGL-IATGIINILFGFSSSLWAF 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 95 TGSWMGLAFMRGImgvseasAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQFAFIVAGILA 174
Cdd:PRK11663 115 ALLWVLNAFFQGW-------GWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIALHYGWRYGMMIAGIIA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 175 VIAAFIWLIFYKDPKDAKRLSP--EERS-YIENGQEKHLNNAKKEKTSVINILKQRNFWGIGISRFLADPAWGTINFWVP 251
Cdd:PRK11663 188 IVVGLFLCWRLRDKPQAMGLPSvgEWRHdALELAQQQEGAGLSRKEILTKYVLLNPYIWLLSFSYVLVYVVRAAINDWGN 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 252 VFFVETLHFSL----KEIAMFVWLPFlmadLGCLASGFVA-KFFN-ERG-ISLINSRRITFTIGAI-LMTTIGLVsiien 323
Cdd:PRK11663 268 LYMSETLGVDLvtanSAVSMFELGGF----IGALVAGWGSdKLFNgNRGpMNLIFAAGILLSVGSLwLMPFASYV----- 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 324 pYIAVLLISIGG--FSHQLLSTVAAtlgADLFKKNEVATAVGMAGACAWSGQLIFNLFIGAFVSIIGFGPFFIALAVfdL 401
Cdd:PRK11663 339 -MQAACFFTIGFfvFGPQMLIGMAA---AECSHKEAAGAATGFVGLFAYLGAALSGYPLAKVLEIWHWTGFFVVISI--A 412
|
....*....
gi 545256359 402 IGAVALWIL 410
Cdd:PRK11663 413 AGISALLLL 421
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
34-408 |
4.09e-13 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 70.28 E-value: 4.09e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 34 PTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMGHALTGSWMGLAFMRGIMGVSEA 113
Cdd:cd17478 20 PLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 114 SAIPAGVKTASTwFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQFAFIVAGILAVIAAFIWLIFYKDPKDAKR 193
Cdd:cd17478 100 AFHPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAK 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 194 lspeersyiENGQEKHLNNAKKEKTSVINILkqrnfWGIGISRFLADPAwgtINFWVPVFFVETLhFSLKEIAMFVWLPF 273
Cdd:cd17478 179 ---------KAAAKSSARSTLKGVWRALLLL-----LIIVFLRSWVLSS---LTTFLPFYLVQRG-YSLVFAGLLLSLFL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 274 LMADLGCLASGFVAKFFNergislinsRRITFTIGAILMTTIGLVSIIENPYIAVLLISIGGFSHQLLSTVAATLGADLF 353
Cdd:cd17478 241 FAGAIGTLIGGPLSDRFG---------RRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELL 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 545256359 354 KKNeVATAVGMAGACAWSGQLIFNLFIGAFVSIIGFGPFFIALAVFDLIGAVALW 408
Cdd:cd17478 312 PGN-VGLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
4-192 |
6.34e-13 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 69.91 E-value: 6.34e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 4 IKHYRWQMIVLVCFITIINYLdrtALGVAAPTIMSD-LGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICA 82
Cdd:COG2223 202 LRDPRFWLLSLLYFGTFGSFI---GFSSWLPPYLVDqFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVF 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 83 VIWGLATMGHALT-GSWMGLAFMRGIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCI-MF 160
Cdd:COG2223 279 ALMALGLLLLALAlGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLdAT 358
|
170 180 190
....*....|....*....|....*....|..
gi 545256359 161 HSWQFAFIVAGILAVIAAFIWLIFYKDPKDAK 192
Cdd:COG2223 359 GSYTAAFLVFAVLALVALVLTLLLYRRPRRAA 390
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
12-185 |
1.05e-12 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 69.14 E-value: 1.05e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 12 IVLVCFITIINYLDRTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMG 91
Cdd:cd17323 1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 92 HALTGSWMGLAFMRGIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQFAFIvag 171
Cdd:cd17323 81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFW--- 157
|
170
....*....|....
gi 545256359 172 ILAVIAAFIWLIFY 185
Cdd:cd17323 158 FLAIISGFCLILIF 171
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
17-410 |
1.18e-12 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 68.79 E-value: 1.18e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 17 FITIINYLDRTALGVAAPTIM----SDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMGH 92
Cdd:cd17329 3 VLLIGSFLNRLGFFMVWPFMAiylhQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 93 ALTGSWMGLAFMRGIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHSwQFAFIVAGI 172
Cdd:cd17329 83 GFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSF-RLLFLAAAV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 173 LAVIAAFIWLIFYKDPKDAKRLSPEERSYIENGQekhlnnakkektsvinILKQRNFWGIGISRFLADPAWGTINFWVPV 252
Cdd:cd17329 162 LFLLAALVLLFLLPETRPKRRAAEKTEILRGYKI----------------VLRDRAFLLFLLASFLISLIYFQLESTLPV 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 253 FFVETLHFSLKEIAMFVWLPFLMAdlgCLASGFVAKFFNERGISLInsrritFTIGAILMTT-IGLVSIIENPYIAVLLI 331
Cdd:cd17329 226 YVVEILGLGESLLGLLLALNALLI---VLLQFPVARLVERFRLRKI------LMIGILLFAIgFAVLAFANTLAVLILAM 296
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 545256359 332 SIGGFSHQLLSTVAATLGADLFKKNEVATAVGMAGACAWSGQLIFNLFIGAFVSIIGFGPFFIALAVFDLIGAVALWIL 410
Cdd:cd17329 297 IVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
12-410 |
2.01e-12 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 68.37 E-value: 2.01e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 12 IVLVCFITIINYLDRTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMG 91
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 92 HALTGSWMGLAFMRGIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQFAFIVAG 171
Cdd:cd17320 81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 172 ILAVIAAFIWLIFYKDPKDAKRLSPEERSYIENGqekhlnnakkektsvINILKQRNFWG---IGISRFLADPAWGTINf 248
Cdd:cd17320 161 LLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAY---------------KRVLKNRRFLGyalALGLSFAGLFAYLAAA- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 249 wvPVFFVETLHFSLKEIAMFVWLPFLMADLGCLASGFVAKFFNERgiSLINSRRITFTIGAILMTTIGLVsIIENPYIAV 328
Cdd:cd17320 225 --PFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPR--RLLRLGLLLLLAAALVLLLAALL-GGLSLWPLV 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 329 LLISIGGFSHQLLSTVAATLGADLFKKnevatAVGMAGACAWSGQLIFNLFIGAFVSIIGFG---PFFIALAVFDLIGAV 405
Cdd:cd17320 300 APLFLIFFGFGLIFPNATSLALEPFPH-----VAGTASALLGFLQFLIGALAGALVGLLPNGtalPMGLLILVLGLLALL 374
|
....*
gi 545256359 406 ALWIL 410
Cdd:cd17320 375 LLILL 379
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
23-411 |
7.96e-12 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 66.28 E-value: 7.96e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 23 YLDRTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMGHALTGSWMGLA 102
Cdd:cd17488 16 YLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGFSSSLWAFA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 103 FMRGIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQFAFIVAGILAvIAAFIWL 182
Cdd:cd17488 96 VLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGMYVPGIIA-ILMGIVL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 183 IFykdpkdakRLspeersyiengqekhlnnakKEKTSVInilkqrnfWGIGISRFLADPAWGTINFWVPVFFVETLHFSL 262
Cdd:cd17488 175 CW--------RL--------------------RDRPPYI--------WLLAFCYVLVYVVRTAINDWGNLYLSETHGYSL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 263 KEIAMFVWLPFLMADLGCLASGFVAKFF---NERGISLINSRRITFTIGAILmttigLVSIIENPYIAVLLISIGGFSH- 338
Cdd:cd17488 219 VKANSAVSLFEVGGLIGALVAGWGSDKLfkgNRGPMNLIFALGLLVSVGALW-----LVPVHSYWLLATCFFTIGFFVFg 293
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 545256359 339 -QLLSTVAAtlgADLFKKNEVATAVGMAGACAWSGQLIFNLFIGAFVSIIGFGPFFIALAVFDLIGAVALWILI 411
Cdd:cd17488 294 pQMLIGMAA---AECSHKDAAGSATGFVGLFAYLGAALAGYPLAKVIESWGWSGFFIVISIAAAISGLLLLPLL 364
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
8-407 |
8.38e-12 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 66.28 E-value: 8.38e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 8 RWQMIVLVCFITIINYLDRTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLK--LGFFICAVIW 85
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRplMALAGIMVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 86 GLATMGHALTGSWMGLAFMrGIMGVSEASAIPAGVKTASTWFPAKeRGIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQF 165
Cdd:cd17314 81 GYTYLSYVFNSFPLSYACF-VFIGAGTGILYGSAVLVTTQYFPDT-KGLALGLPTTGYSLGLVLGSPLLRILWVFYGLAL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 166 AFIVAGILAVIA-AFIWLIFYKDPKDAKRlspeersyiengqEKHLNNAKKEKTSVINILKQrnFWGIGISRFLADPAWg 244
Cdd:cd17314 159 VYTILGILAAIVlSVVSLLGFKEPPDNQA-------------RLHVQKKKTQTMGEIFRDKV--FWILFIAIFLVLIGG- 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 245 tinfWVPVFFVETLHFSLKEIAMFVWLPF-----LMADLGCLASGFVAKFFnergISLINSRRITFTIGAILMTTIgLVS 319
Cdd:cd17314 223 ----FLFIANMASLVRSLQLDAPSFVTKLmsiygLFNAFGRLLWGIVADFF----GGRLSTLSILLTILGLGLCAF-LFL 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 320 IIENPYIAVLLISIGGFSHQLLSTVAATLGADLFKKNEVATAVGMAGACAWSGQLIFnLFIGAFVSIIGFGPFFIAL--A 397
Cdd:cd17314 294 LKMTPVGLVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILG-PMLGAKFYDRTPSYISAVYiyA 372
|
410
....*....|
gi 545256359 398 VFDLIGAVAL 407
Cdd:cd17314 373 VIVFLASAIL 382
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
23-301 |
1.58e-11 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 65.43 E-value: 1.58e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 23 YLDRTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMGHALTGSWMGLA 102
Cdd:cd17343 16 YFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFSGSSSVWVFS 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 103 FMRGIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQFAFIVAGILAVIAAFIWL 182
Cdd:cd17343 96 ILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTLSISGTVAVVMSVVCL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 183 IFYKDpkdakrlSPEERSYIENGQEKHLNNAKKEKTSVINI---LKQRNFWGIGISRFLADPAWGTINFWVPVFFVETLH 259
Cdd:cd17343 176 LFIKN-------EPSDVGLNNIEEEESKGKKKKSPRGESTLkelLLSPFLWLLSLGYLVVFGVKTAVTDWGQLFLIQDKG 248
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 545256359 260 FSLKEIAMFVwlpfLMADLGCLASGFVAKFFNERGISLINSR 301
Cdd:cd17343 249 QSALTGSSFM----SSLEVGGFVGSIAAGYLSDWAVAKHGSS 286
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
8-183 |
1.76e-11 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 65.90 E-value: 1.76e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 8 RWQMIVLVCFITIINYLDRTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGL 87
Cdd:PRK14995 4 QWLTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 88 ATMGHALTGSWMGLAFMRGIMGVSEASAIPA---GVKTasTWFPAKERGIATGVF----NMGTSFGamlapPLIAWCIMF 160
Cdd:PRK14995 84 ASLAAAFSPTASWLIATRALLAIGAAMIVPAtlaGIRA--TFTEEKQRNMALGVWaavgSGGAAFG-----PLVGGILLE 156
|
170 180
....*....|....*....|....*.
gi 545256359 161 H-SWQFAFI--VAGILAVIAAFIWLI 183
Cdd:PRK14995 157 HfYWGSVFLinVPIVLVVMGLTARYV 182
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
15-405 |
3.31e-11 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 64.26 E-value: 3.31e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 15 VCFITIINYLDRTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMGHAL 94
Cdd:cd17333 1 LYISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 95 TGSWMGLAFMRGIMGVSeASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCI-MFHSWQFAFIVAGIL 173
Cdd:cd17333 81 TPSIYLFVVLMFLAGLG-AGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLtSELSWSWAYLIIGLI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 174 AVIAAFIWLIFYKDPKDAKRLspeersyiengqekHLNNAKKEKTSVINILKQRNFWGIGISRFLADPAWGTINFWVPVF 253
Cdd:cd17333 160 YLLLAILILLTLFPELPSARN--------------PQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSY 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 254 FVETLHFSLKEIAMFVWLPFLMADLGCLASGFVakffnergISLINSRRITFTIGAILMTTIGLVSIIENPYIAVLLISI 333
Cdd:cd17333 226 LVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPI--------SRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATAL 297
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 545256359 334 GGFSHQLLSTVAATLGADLFKKnEVATAVGMAGACAWSGQLIFNLFIGAFVSIIGFGPFFIALAVFDLIGAV 405
Cdd:cd17333 298 LGLFMAALFPTILSLGISNLPY-AKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFV 368
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
24-410 |
3.97e-10 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 61.04 E-value: 3.97e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 24 LDRTALGVAAPTIMSDLGiSKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMGHALTGSWMGLAF 103
Cdd:cd17502 10 LDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIV 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 104 MRGIMGVSeASAIPAGVKTA-STWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQFAFIVAGILAVIAAFIWl 182
Cdd:cd17502 89 GRAIQGIG-GGGLMSLAFIIiADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLALALL- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 183 ifykdpkdakrlspeersyiengqekhlnnakkektsvinilkqRNFWGIGISRFLADPAWGTINFWVPVFFVETLHFSL 262
Cdd:cd17502 167 --------------------------------------------RTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSA 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 263 KEIAMFVWLPFLMADLGCLASG-FVAKFFNERGISLINSrrITFTIGAILMTTIGLVSIIENPYIAVLLISIG-GFSHQL 340
Cdd:cd17502 203 TKSGVRLLPLIIGLVIGSIISGaLISKTGRYKPLIVIGT--ILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGlGIGFQQ 280
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 341 LsTVAATLGADlfkKNEVATAVGMAGACAWSGQLIFnlfigafvsiIGFGPFFIALAVFDLIGAVALWIL 410
Cdd:cd17502 281 P-LVAVQNAVP---PADVGVATATNTFFRSLGGTLG----------VAITDVFLVALALAALAFLLSLFL 336
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
40-408 |
7.04e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 60.69 E-value: 7.04e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 40 LGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLG-----FFICAVIWGLATM------GHALTGSWMGLAFMRGIM 108
Cdd:COG2211 41 LGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGrrrpwILIGAIPLALSFVllftapDLSPTGKLIYALVTYLLL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 109 GVSEASAIPAgvktASTWFPA-----KERGIATGVFNMGTSFGAMLAPPLIAWCIMF------HSWQFAFIVAGILAVIA 177
Cdd:COG2211 121 GLAYTLVNIP----YSALGAEltpdyEERTRLSSWRFAFAGLGGLLASVLPPPLVAAfggdaaLGYRLTALIFAVLGLLA 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 178 AFIWLIFYKDPKDAKRlspeersyiengqekhlnNAKKEKTSVINILKQRNFWGIGISRFLADPAWGTINFWVPVFFVET 257
Cdd:COG2211 197 FLLTFFGTKERPVPEE------------------EKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYV 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 258 LHFSLKEIAMFVWLPFLMADLGCLASGFVAKFFnergislinSRRITFTIGAILMtTIGLVSII----ENPYIAVLLISI 333
Cdd:COG2211 259 LGLSAALVGLLLALYFLAALLGAPLWPRLAKRF---------GKKKAFIIGLLLA-ALGLLLLFflgpGNLWLLLVLAAL 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 334 GGFSHQLLSTVAATLGADLFKKNEVATAVGMAGAC--AWS-----GQLIFNLFIGAFVSIIGFGP--------------- 391
Cdd:COG2211 329 AGIGLGAILVLPWAMLADVVDYDEWKTGRRREGLYfgIFTfaiklGQALAGALAGLLLALFGYVAgaaqspsaltgirll 408
|
410
....*....|....*..
gi 545256359 392 FFIALAVFDLIGAVALW 408
Cdd:COG2211 409 FFLLPAVLLLLAALLLL 425
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
27-180 |
1.68e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 59.13 E-value: 1.68e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 27 TALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMGHALTGSWMGLAFMRG 106
Cdd:cd17504 13 TMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRA 92
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 545256359 107 IMGVSEAsAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQFAFIVAGILAVIAAFI 180
Cdd:cd17504 93 LQGIGGA-VFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAAL 165
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
9-184 |
1.91e-09 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 59.12 E-value: 1.91e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 9 WQMIVLVCFITIINYLDRTALGVAAPTIMSDLGI-SKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGL 87
Cdd:cd17473 196 WKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGgSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMAL 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 88 ATMGHALTGSWMGLAFMRGIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCI-MFHSWQFA 166
Cdd:cd17473 276 GFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVnLTGGLSGA 355
|
170
....*....|....*...
gi 545256359 167 FIVAGILAVIAAFIWLIF 184
Cdd:cd17473 356 FLILGVLALVLAIVLLLL 373
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
12-291 |
2.43e-09 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 58.82 E-value: 2.43e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 12 IVLVCFITIINYLDRTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMG 91
Cdd:PRK11551 17 IGLCFLVALLEGLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 92 HALTGSWMGLAFMRGIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPpLIAWCIMFHS-WQFAFIVA 170
Cdd:PRK11551 97 TAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALAS-VIGVLAAGDAaWRHIFYVG 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 171 GI---LAVIAAFIWLifykdpkdakrlsPEERSYIENGQekhlnnAKKEKTSVINILkqrnfwgigisrFLADPAWGTIN 247
Cdd:PRK11551 176 GVgplLLVPLLMRWL-------------PESRAFAQAAG------AGKQRAPVLRAL------------FGEGRATATLL 224
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 545256359 248 FWVPVFFVET-LHFSLKeiamfvWLPFLMADLGC--LASGFVAKFFN 291
Cdd:PRK11551 225 LWISYFFTLIvLYFLLN------WLPSLLVGQGLsrSQAGLVQIAFN 265
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
37-182 |
5.64e-09 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 57.55 E-value: 5.64e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 37 MSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMGHALTGSWMGLAFMRGIMGVSEASAI 116
Cdd:cd17370 226 AQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQE 305
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 545256359 117 PAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQFAFIVAGILAVIAAFIWL 182
Cdd:cd17370 306 SIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
39-408 |
1.88e-08 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 56.12 E-value: 1.88e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 39 DLGISKEQYSWI----VSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMGHALTGSW---MGLAFMRGIMGVS 111
Cdd:cd17357 39 GLNLSDSELDLLwsliVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSKSAkspELLIFGRFLVGIA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 112 EASAIPAGVKTASTWFPAKERGiATGVFN-MGTSFGAMLApPLIAWCIMF---HSWQFAFIVAGILAVIAAFIWLIFYKD 187
Cdd:cd17357 119 CGLSTGFVPMYLQEISPSELRG-ALGSLTqIGVTLGILLG-QVFGLPSVLgteTLWPYLLFFPGIPALLQLAALPFFPES 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 188 PK--------------DAKRLSPEERSYIENGQEKH---LNNAKKEKTSVINILKQRNFW---GIGISrFLADPAWGTIN 247
Cdd:cd17357 197 PKflliskgdeeeaekSLKFLRGIEDDVDQELEEIKkesEQMGDQKQVSLMQLLRDPSLRlplLLVLV-VSASQQFSGIN 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 248 --FWVPVFFVETLHFSLKEIAmfvWLPFLMADL---GCLASGFVAKFFNERGISLINsrrITFTIGAILMTTIGLVSIIE 322
Cdd:cd17357 276 aiFFYSTFIFENAGFSPQLAE---WANLGIGIVnvlSTIVGPFLIEKVGRRPLLLIS---LSVCAVALLLMSVFLFLSEQ 349
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 323 N---PYIAVLLISIGGFSHQL-LSTVAATLGADLFKKNEVATAVGMAGACAWSGQLIFNLFIgAFVSIIGFGPFFIALAV 398
Cdd:cd17357 350 NswmSYGCIVAIFLFIFFFAIgLGPIPWFIGAELFPQAPRSAAQSLGSSVNWTSNFIVGMAF-PPLQSIGGGFVFIIFAI 428
|
410
....*....|
gi 545256359 399 FDLIGAVALW 408
Cdd:cd17357 429 PCALFLLYLY 438
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
7-184 |
2.18e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 55.70 E-value: 2.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 7 YRWQMIVLVCFITIINYLDRTALGVAAPTIMSD-LGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIW 85
Cdd:cd06173 205 RRSPLLRLLLLALALFALLGGALTVLLPLLAKEvLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 86 GLATMGHALTGSWMGLAFMRGIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQF 165
Cdd:cd06173 285 GLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSA 364
|
170
....*....|....*....
gi 545256359 166 AFIVAGILAVIAAFIWLIF 184
Cdd:cd06173 365 VFLLAGALLLLAALLLLLL 383
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
8-150 |
2.64e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 55.37 E-value: 2.64e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 8 RWQMIVLVCFITIINYLDRTALGVAAPTIMSD-LGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWG 86
Cdd:COG2814 205 RRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLA 284
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 545256359 87 LATMGHALTGSWMGLAFMRGIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLA 150
Cdd:COG2814 285 LGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
9-182 |
2.65e-08 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 55.30 E-value: 2.65e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 9 WQMIVLVCFITIINYldrtALGVAAPTIM-SDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGL 87
Cdd:cd17316 180 LLLILLWFFISFGYY----GLTTFLPTYLqTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGI 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 88 AT--MGHALTGSWMGLAFMRGIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCI-MFHSWQ 164
Cdd:cd17316 256 LAlpLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLaSTGGTG 335
|
170
....*....|....*...
gi 545256359 165 FAFIVAGILAVIAAFIWL 182
Cdd:cd17316 336 VPALILALLAIVALIVAL 353
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
8-262 |
3.45e-08 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 55.49 E-value: 3.45e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 8 RWQMIVLVCFITIINYLDRTALGVAAPTIMsDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDN----IGLKLGFFICAV 83
Cdd:PRK11273 27 RWQIFLGIFFGYAAYYLVRKNFALAMPYLV-EQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRsnprVFLPAGLILAAA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 84 IWGLATMGHALTGSWMGLAFMRGIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPL----IAWcim 159
Cdd:PRK11273 106 VMLFMGFVPWATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGLPPLLfllgMAW--- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 160 FHSWQFAFIVAGILAVIAAFIWLIFYKDPKDAKRLSPEER---SYIENGQEKHLNNAKKEKTSVINILKQRNFWGIGISR 236
Cdd:PRK11273 183 FNDWHAALYMPAFAAILVALFAFAMMRDTPQSCGLPPIEEyknDYPDDYNEKHEQELTAKQIFMQYVLPNKLLWYIAIAN 262
|
250 260
....*....|....*....|....*..
gi 545256359 237 -FLADPAWGTINfWVPVFFVETLHFSL 262
Cdd:PRK11273 263 vFVYLLRYGILD-WSPTYLKEVKHFAL 288
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
27-410 |
4.26e-08 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 54.89 E-value: 4.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 27 TALGVAAPTIMSD-LGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMGHALTGSWMGLAFMR 105
Cdd:cd17473 16 AAIAPALPAIAQHfVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASR 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 106 GIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHsWQFAFIVAGILAVIAAFIWLiFY 185
Cdd:cd17473 96 ALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIG-WRAPFLVYLLALPVLILVLL-FL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 186 KDPKDAKrlspeersyienGQEKHLNNAKKEktsvinILKQRNFWGIGISRFLADPAWGTINFWVPVFFVETLHFSLKEI 265
Cdd:cd17473 174 PEPARKS------------KSAASPGAATAA------ALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 266 AMFVWLPFLMADLGCLASGFVAKFFNERGISLinsrrITFTIGAILMTTIGLVSiieNPYIAVLLISIGGFSHQLLSTVA 345
Cdd:cd17473 236 GLALAIASLAGAIGALLFGRLKRRLGKRRLLA-----IGFALMALGFLLLALAS---GLWVVLLGAILAGLGFGLLLPTL 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 545256359 346 ATLGADLFKKNEVATAVGMAGACAWSGQLIFNLFIGAFVSII-GFGPFFIALAVFDLIGAVALWIL 410
Cdd:cd17473 308 NSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTgGLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
34-407 |
4.65e-08 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 54.49 E-value: 4.65e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 34 PTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMGHALTGSWMGLAFMRGIMGVSeA 113
Cdd:cd17477 20 SLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIG-L 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 114 SAIPAGVKTA-STWFPAKERGIATGVFNMGTSFGAMLAPPLIAWciMFHSWQFAFIVAGILAVIAAFIWLIFYKDPKDAK 192
Cdd:cd17477 99 AGLFVVSESWlNALATNENRGRVLGLYSTVLGLGFALGPLLLAL--VGTAGALPFLIAAVLLLLALVPLLLTRRAAPEIE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 193 rlspeersyiengqekhlnnaKKEKTSVINILKQrnFWGIGISRFLADPAWGTINFWVPVFFVEtLHFSLKEIAMFVWLP 272
Cdd:cd17477 177 ---------------------EAESISLRRLLRI--APLALLGAFVAGFLEGAFYSLLPLYGLR-LGLSVAQAALLLAAF 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 273 FLMADLGCLASGFVAKFFNERGIslinsrrITFTIGAILMTTIGLVSIIENPY-IAVLLISIGGFSHqLLSTVAATLGAD 351
Cdd:cd17477 233 VLGGLLLQWPLGWLADRFDRRRV-------LLGCALLGALAALLLPLVPGLPLaLLVLLFLWGGAAG-PLYTLALALAGD 304
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 545256359 352 LFKKNEVATAVGMAGACAWSGQLIFNLFIGAFVSIIGFGPFFIALAVFDLIGAVAL 407
Cdd:cd17477 305 RLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
13-202 |
5.74e-08 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 54.94 E-value: 5.74e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 13 VLVCFITIINYLDRTALGVAAPTIMSDLGiSKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLgFFICAviWGLATMGH 92
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRW-FFIGG--NLLGVVGS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 93 ALTG---SWMGLAFMRGIMGVSeASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIM--FHSWQFAF 167
Cdd:cd06179 77 IVAGtakSVNMLIGGQALIGIG-AGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEanAAGWRWIF 155
|
170 180 190
....*....|....*....|....*....|....*
gi 545256359 168 IVAGILAVIAAFIWLIFYKDPKDAKRLSPEERSYI 202
Cdd:cd06179 156 YINAIFNALALILLFFFYHPPPRPQLHGSSTRQKL 190
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
34-409 |
1.35e-07 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 53.38 E-value: 1.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 34 PTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFficaviwGLATMGHALTGSWMGLAFMRGIMGVSEA 113
Cdd:cd17331 24 PYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAAL-------VLSFLSSALSYLLLAFASSVPMLFLSRL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 114 SAI-----PAGVKTASTWFPAKERGIATGvfNMGTSF--GAMLAPPLIAWCIMFHSWQFAFIVAGILAVIAAFIWLIFYK 186
Cdd:cd17331 97 PSVfmhamQAAQMVVTDLTDPGERAAALG--RLGLSYgiGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 187 DPKDAKRLSPEERSYIENGQEKhlnnakkeKTSVINILKQRNFWGIGISRFLADPAWGTINFWVPVFFVETLHFSLKEIA 266
Cdd:cd17331 175 SNTKSKREKEAKESASPPSVFN--------LKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 267 MFV-WLPFLMADLGCLASGFVAKFFNERgiSLINSRRITFTIGAILMttiglvSIIENPYIAVLLISIGGFSHQLLSTVA 345
Cdd:cd17331 247 YLMsYAGVLGMVVQGLLVGPLTKRFGER--SLLKLSVALLAIGYLLL------AFVTTVWQLLVLLLPLVIGGSVLYTVI 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 545256359 346 ATLGADLFKKNEVATAVGMAGACAWSGQLIFNLFIGAFVSIIGFGPFFIALAVFDLIGAVALWI 409
Cdd:cd17331 319 TSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAINGLLTVYLLL 382
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
34-191 |
2.09e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 52.57 E-value: 2.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 34 PTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIG-LKLGFFICAVIWGLATMGHALTGSWMGLAFMrGIMGVSE 112
Cdd:COG2807 239 PPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGdRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWA-VLLGLGQ 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 113 ASAIPAGVKTASTWFP-AKERGIATGVFNMGTSFGAMLAPPLIAWCI-MFHSWQFAFIVAGILAVIAAFIWLIFYKDPKD 190
Cdd:COG2807 318 GGLFPLALTLIGLRARtPAEAAALSGMAQSVGYLLAALGPLLVGALHdATGSWTAALLLLAALAVLMLVAGLLAGRPYVE 397
|
.
gi 545256359 191 A 191
Cdd:COG2807 398 D 398
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
32-183 |
2.39e-07 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 52.39 E-value: 2.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 32 AAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMGHALTGSWMGLAFMRGIMGVS 111
Cdd:TIGR00710 27 AFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFG 106
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 545256359 112 EASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQFAFIVAGILAVIA-AFIWLI 183
Cdd:TIGR00710 107 ASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLsALIFFI 179
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
48-183 |
2.48e-07 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 52.20 E-value: 2.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 48 SWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMGHALTGSWMGLAFMRGIMGVSEASAIPAGVKTASTWF 127
Cdd:cd17317 28 ALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIV 107
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 545256359 128 PAKERGIATGVFNMGTSFGAMLAPPLiawCIMFHSWQ-FAFIVAGILAVIAAFIWLI 183
Cdd:cd17317 108 GPKYRSFVGILFGLFWALGYMLLALL---AYLIRDWRwLQLAISLPGLLFLLLLWWL 161
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
11-184 |
2.94e-07 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 52.17 E-value: 2.94e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 11 MIVLVCFIT-IINYLDRTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLAT 89
Cdd:cd17352 3 VVVFASFLVnFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 90 MGHAL-TGSWMGLAFMRGIMGVSEASAIPAGVKTASTWFpAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQFAFI 168
Cdd:cd17352 83 LLSSFaTSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYF-EKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALL 161
|
170
....*....|....*.
gi 545256359 169 VAGILAVIAAFIWLIF 184
Cdd:cd17352 162 ILGGLCLNLCVCGLLL 177
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
34-183 |
3.21e-07 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 52.17 E-value: 3.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 34 PTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFID--NIGLKLGFFICAVIWGLATMGHALTGSWMGLAFMRGIMGVS 111
Cdd:cd17352 207 PSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADkpRIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFC 286
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 545256359 112 EASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCI-MFHSWQFAFIVAGILAVIAAFIWLI 183
Cdd:cd17352 287 SGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRdYTGDYDAAFYFCGACLLLSGVLLFL 359
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
31-190 |
4.05e-07 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 51.53 E-value: 4.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 31 VAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMGHAL-TGSWMGLAFMR---G 106
Cdd:TIGR00886 23 LAVFLIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLaVQSYSVLLLIRlfiG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 107 IMGVSEASAIPagvkTASTWFPAKERGIATGVF----NMGTSFGAMLAPPLIAWCIMFHS--------WQFAFIVAGILA 174
Cdd:TIGR00886 103 IAGGSFASCMP----WISFFFPKKIQGTALGLAagwgNMGGGVAQFVMPPIIGSLIFGGGqpahlawgWAFVIVPAGILL 178
|
170
....*....|....*.
gi 545256359 175 VIAAFIWLIFYKDPKD 190
Cdd:TIGR00886 179 LPALLIFFVGADTPPG 194
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
227-413 |
8.42e-07 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 50.65 E-value: 8.42e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 227 RNFWGIGISRFLADPAWGTINFWVPvFFVETLHFSLKEIAMFVWLPFLMADLGCLASGF-VAKFfnergislinSRRITF 305
Cdd:COG2223 5 RVLLLATLAFFLAFGVWYLWSVLAP-PLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFlVDRF----------GPRRVL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 306 TIGAILMTTIGLVSIIENPYIAVLLIS-IGGFSHQLLSTVAATLGADLFKKNEVATAVGMAGACAWSGQLIFNLFIGAFV 384
Cdd:COG2223 74 LIGLLLLGIGLLLLALAVSYWLLLLLGlLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLI 153
|
170 180
....*....|....*....|....*....
gi 545256359 385 SIIGFGPFFIALAVFDLIGAVALWILIKD 413
Cdd:COG2223 154 AAFGWRNAFLILGILLLVVAVLAWLFLRD 182
|
|
| MFS_SLC49 |
cd17334 |
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ... |
8-179 |
1.03e-06 |
|
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340892 [Multi-domain] Cd Length: 407 Bit Score: 50.48 E-value: 1.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 8 RWQMIVLVCFITIINYLDRTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGL 87
Cdd:cd17334 2 RWVVLLLFSLLSFSNAMQWITFSPIADEARTFFDLSASQINWLSLVYPIVYVPGVFAFCWLLDKVGLRIGVLIGAALNAL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 88 ATMGHALTGSWMGLAFMRGIMGVSEASA----IPAGVKTASTWFPAKERGIATGVFNMGTSFG---AMLAPPLIA----- 155
Cdd:cd17334 82 GSVLKCIPLGQQPKFALLVLGQVLNALAqvlvLSLPPLIAAVWFPPKERTTATAIASLANFLGcaiGFLLPPVVVpppkg 161
|
170 180
....*....|....*....|....*...
gi 545256359 156 ----WCIMFHSwQFAFIVAGILAVIAAF 179
Cdd:cd17334 162 tkkeFGAVFYG-EFGFACLLLALVLALF 188
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
9-180 |
2.27e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 49.48 E-value: 2.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 9 WQMIVLVCFITIINYLDRTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLA 88
Cdd:cd17478 194 WRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPF 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 89 TMGHALTGSWMGLAFMrGIMGVSEASAIPAGVKTASTWFPAKeRGIATGVFnMGTSFG-AMLAPPLIAWCIMFHSWQFAF 167
Cdd:cd17478 274 LLLFLLTPGIWSYILL-VLAGFLLFASFPVTVVLAQELLPGN-VGLASGLM-MGLSFGlGGIGAPVLGALADAFGLESVL 350
|
170
....*....|...
gi 545256359 168 IVAGILAVIAAFI 180
Cdd:cd17478 351 LILALLPLLGALL 363
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
225-421 |
4.45e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 48.43 E-value: 4.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 225 KQRNFWGIGISRFLADPAWGTINFWVPvFFVETLHFSLKEIAMFVWLPFLMADLGCLASGFVAKFFnergislinSRRIT 304
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRF---------GRRRV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 305 FTIGAILMTTIGLVS-IIENPYIAVLLISIGGFSHQLLSTVAATLGADLFKKNEVATAVGMAGACAWSGQLIFNLFIGAF 383
Cdd:COG2814 78 LLLGLLLFALGSLLCaLAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLL 157
|
170 180 190
....*....|....*....|....*....|....*...
gi 545256359 384 VSIIGFGPFFIALAVFDLIGAVALWILIKDNKQTDDHS 421
Cdd:COG2814 158 ADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARAR 195
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
232-413 |
5.26e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 48.18 E-value: 5.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 232 IGISRFLADPAWGTINFWVPVFFVETLHFSLKEIAMFVWLPFLMADLGCLASGFVAKFFnergislinSRRITFTIGAIL 311
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRF---------GRRRVLLIGLLL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 312 MTTIGLVSIIENPYIAVLLIS-IGGFSHQLLSTVAATLGADLFKKNEVATAVGMAGACAWSGQLIFNLFIGAFVSIIGFG 390
Cdd:pfam07690 72 FALGLLLLLFASSLWLLLVLRvLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWR 151
|
170 180
....*....|....*....|...
gi 545256359 391 PFFIALAVFDLIGAVALWILIKD 413
Cdd:pfam07690 152 AAFLILAILSLLAAVLLLLPRPP 174
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
34-180 |
5.92e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 47.97 E-value: 5.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 34 PTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLK---LGFFICAVIwGLATMGHALTGSWM--GLAFMRGIM 108
Cdd:cd17365 195 PKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKrvlALFFALGAV-SLALLGVSPASLVLlyVLVFLAGAC 273
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 545256359 109 GVSEASAIPAgvkTASTWFPAKER----GIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQFAFIVAGILAVIAAFI 180
Cdd:cd17365 274 VNGAQVGLYA---LAARFYPTEVRatgvGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLALAIPAALGALAVLL 346
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
45-337 |
7.31e-06 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 47.85 E-value: 7.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 45 EQYSWIVSVFQLAYTIGQPIMGFFIDNIGLK--LGFFI-CAVIWGLATMGHALTGSWMGLAfMRGIMGVSEASAIPAGVK 121
Cdd:cd17381 65 ETQGWILGSFFYGYIITQIPGGYLASKIGGKllLGFGIlGTAVFTLLTPLAADLGAGYLIA-VRALEGLGEGVTFPAMHA 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 122 TASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQFAFIVAGILAVIAAFIWLIFYKDpkdakrlspeersy 201
Cdd:cd17381 144 MWASWAPPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLVMP-------------- 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 202 iengqekhlnnakkektsvinilkqrnFWGIGISRFLADPAWGTINFWVPVFFVETLHFSLKEIAMFVWLPFLMADLGCL 281
Cdd:cd17381 210 ---------------------------LWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMI 262
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 545256359 282 ASGFVAKFFNER-GISLINSRRITFTIG----AILMTTIGLVSIIENPYIAVLLIS--IGGFS 337
Cdd:cd17381 263 LSGQIADNLREKqNFSTVCVRKIFTLIGmigpAVFLLAAGFTGCNYSLAVAFLTISstLGGFS 325
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
2-184 |
1.08e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 47.18 E-value: 1.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 2 KYIKHYRWQMIVLVCFITIINYLDRTALGVAAPTIMSDL-GISKEQYSWIVSVFQLAYTIGQPIMG-----FFIDNIGLK 75
Cdd:cd17474 190 DLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLyGISPIIIGLLFAGWSVLLALGSLFVGrllkkRFGARRILV 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 76 LGFFICAVIWGLATMGHALTGSWMGLAfmrgIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIA 155
Cdd:cd17474 270 IGLLLYALSLLLLGFVPSLALLLIAIV----LFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFG 345
|
170 180
....*....|....*....|....*....
gi 545256359 156 WCIMFHSWQFAFIVAGILAVIAAFIWLIF 184
Cdd:cd17474 346 LLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_MFSD1 |
cd17340 |
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily ... |
14-410 |
1.95e-05 |
|
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily domain-containing protein 1 (MFSD1) is also called smooth muscle cell-associated protein 4 (SMAP-4). The function of MFSD1 is still unknown. Its expression is affected by altered nutrient intake. During starvation, expression of MFSD1 is downregulated in anterior brain sections in mice while it is upregulated in the brainstem. In mice raised on high-fat diet, MFSD1 is specifically downregulated in brainstem and hypothalamus. MFSD1 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340898 [Multi-domain] Cd Length: 394 Bit Score: 46.50 E-value: 1.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 14 LVCFITIINYLDRTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDN-IGLKLGFFICAVIWGLATMGH 92
Cdd:cd17340 3 LMCFLGFGSYFCYDNPAALQKQFIEDMDINTSQFMLLYSVYSWPNVVLCFFGGFLIDRvFGIRLGTIIFSLLVLIGQLIF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 93 ALTGS----WMGLA--FMRGIMGVSEASAIPAgvkTASTWFPAKER----GIATGVFNMGTSFGAMLAPPLIAWCIMFHS 162
Cdd:cd17340 83 ALGALtnlfWLMLVgrFIFGIGGESLAVAQNT---YAVSWFKGKELnlvfGLQLSFARIGSTVNFNVMPPIYKRISDFYS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 163 WQ----FAFIVAGILAVIAAFIWLIFYKDPKDAKRLSPEERSyiENGQEKHLNNAKKEKTSvinilkqrnFWGI-GISRF 237
Cdd:cd17340 160 GYkslgVALWIGAITCLFSLICAIILGLLDKRAERILKKESN--KTGEVIKLSDVKDFPLS---------FWLIcIICVF 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 238 LADPAWGTINFWvPVFFVETLHFSLKEIAMFVWLPFLMADLGCLASGFVAKFFnergislinSRRITFTIGAILMTTIG- 316
Cdd:cd17340 229 YYVAVFPFIGLG-TVFFEEKYGFSPSEAAAVNSIVYIISAAASPVFGFLVDKV---------GRNILWVLIALVITLLGh 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 317 --LVSIIENPYIAVLLIsigGFSHQLLSTVAATLGADLFKKNEVATAVGMAGACAWSGQLIFNLFIGAFVSIIGFG---P 391
Cdd:cd17340 299 llLAFTFVNPLIAMVIM---GIGYSMLACALWPMVPLVVPEHQLGTAYGFMQSIQNLGLAVFPIIAGSILDKKGYLlleV 375
|
410
....*....|....*....
gi 545256359 392 FFIALAVFDLIGAVALWIL 410
Cdd:cd17340 376 FFIACLCVSLIALIILYLV 394
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
38-415 |
2.13e-05 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 46.50 E-value: 2.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 38 SDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLG-------FFICAVIWGLATMGHALtgsWMgLAFMRGIMGV 110
Cdd:pfam00083 39 SSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSllianvlFVIGAVLQGAAKGKWSV---YQ-LIVGRVLVGI 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 111 SEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLA----------PPLIAWCIMFHswqFAFIVAGILAVIAAFI 180
Cdd:pfam00083 115 GVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAyifglglnktSNSDGWRIPLG---LQLVPALLLIIGLLFL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 181 -----WLIFYKDPKDAKRL------SPEERSYIENGQEKHLNNAKKEKTSVINIL-----KQRNFWGIGISRFLADPAWG 244
Cdd:pfam00083 192 pesprWLVEKGRLEEAREVlaklrgVPDVDRELDEIKDSLEAGQEAEKASWKELFstktrRQRLLIGVMLQIFQQLTGIN 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 245 TINFWVPVFFvETLHFS-----------LKEIAMFVWLPFlmAD--------LGCLASGFVAKFFNERGISLINSRRITF 305
Cdd:pfam00083 272 AIFYYSTTIF-ENLGLSdsflvtiivgvVNFVFTFIAIFL--VDrfgrrpllLLGAAGMAICFVILGIVALLGVSKSDWA 348
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 306 TIGAILMTTIglvsiienpYIAVLLISIGGfshqllstVAATLGADLFKKNEVATAVGMAGACAWSGQLIFNLFIGAFVS 385
Cdd:pfam00083 349 GIVAIVFIAL---------FIAFFAMGWGP--------VPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITD 411
|
410 420 430
....*....|....*....|....*....|
gi 545256359 386 IIGFGPFFIALAVFDLIGAVALWILIKDNK 415
Cdd:pfam00083 412 AIGLGYTFFIFAGLLVLFIIFVFFFVPETK 441
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
2-151 |
2.36e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 46.26 E-value: 2.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 2 KYIKHYRWQMIVLVCFITIINYldrTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIG---LKLGF 78
Cdd:pfam07690 195 KALLRDPVLWLLLALLLFGFAF---FGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGrrrRLLLA 271
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 545256359 79 FICAVIWGLATMGHALTGSWMGLAFMRGIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAP 151
Cdd:pfam07690 272 LLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
15-184 |
3.08e-05 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 45.72 E-value: 3.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 15 VCFITIINYLDRTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMGHAL 94
Cdd:cd17476 3 ISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 95 TGSWMGLAFMRGIMGVSEASAIPAGVKTASTWF-PAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQFAFIVAGIL 173
Cdd:cd17476 83 SPNFIFFIICRALQGLGPAFLLPNAMALLGRTYpPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAIL 162
|
170
....*....|.
gi 545256359 174 AVIAAFIWLIF 184
Cdd:cd17476 163 AAIVAVAAIFW 173
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
31-410 |
3.27e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 45.68 E-value: 3.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 31 VAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLK--------LGFFICAVIWGLATMGHALTGSWMGLA 102
Cdd:cd06173 20 VALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRrlliladlLRALLAAVLALLALLGSLSLWLLLVLA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 103 FMRGIMGVSEASAIPAGVKTAStwfPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQFAFIVAGILAVIAA-FIW 181
Cdd:cd06173 100 FLLGIASAFFGPARQALLPELV---PKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSAlLLL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 182 LIFYKDPKDAKRLSPEERSYIENGQEKhlnnakkektsvinILKQRNFWGIGISRFLADPAWGTINFWVPVFFVETLHFS 261
Cdd:cd06173 177 FIRRPPPAAPGESSSLLLRDLREGLRY--------------LRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 262 LKEIAMFVWLPFLMADLGCLASGFVAKFFNERGISLINsrritFTIGAILMTTIGLVSiieNPYIAVLLISIGGFSHQLL 341
Cdd:cd06173 243 AAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIG-----ALLLGLALLVLGLSP---SLWLLLAALFLLGLAGGLF 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 545256359 342 STVAATLGADLFKKNEVATAVGMAGACAWSGQLIFNLFIGAFVSIIGFGPFFIALAVFDLIGAVALWIL 410
Cdd:cd06173 315 NVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
8-188 |
3.89e-05 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 45.88 E-value: 3.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 8 RWQMIVlVCFITIINYLDRTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGL 87
Cdd:PRK10504 9 RWQLWI-VAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 88 ATMGHALTGSWMGLAFMRGIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQFAF 167
Cdd:PRK10504 88 GSLFCALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIF 167
|
170 180
....*....|....*....|....
gi 545256359 168 IV---AGILAVIAAFIWLIFYKDP 188
Cdd:PRK10504 168 LInipVGIIGAIATLMLMPNYTMQ 191
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
9-186 |
3.95e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 45.66 E-value: 3.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 9 WQMIVLVCFITIINYLdrTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLA 88
Cdd:COG2211 230 FLLLLLAYLLFFLALA--LVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 89 TMGHALTGS---WMGLAFMrGIMGVSEASAIP------AGVKTASTWFPAKER-GIATGVFNMGTSFGAMLAPPLIAWCI 158
Cdd:COG2211 308 LLLLFFLGPgnlWLLLVLA-ALAGIGLGAILVlpwamlADVVDYDEWKTGRRReGLYFGIFTFAIKLGQALAGALAGLLL 386
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 545256359 159 MF--------------HSWQFAFIVAGILAVIAAFIWLIFYK 186
Cdd:COG2211 387 ALfgyvagaaqspsalTGIRLLFFLLPAVLLLLAALLLLFYP 428
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
75-411 |
5.03e-05 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 45.29 E-value: 5.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 75 KLGFFICAVIWGLATMGHALTGSWMGLAFMRGIMGVSEASAIPAGVKTAStWFPAKERGIATGVFNMGTSFGAMLAPpLI 154
Cdd:cd17490 62 KLFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAATWVSFTVLYAS-YFPPDEAAKAMGLINLVNNLGQLIAF-LI 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 155 AWCIMFH-SWQFAFIVAGILAVIaAFIWLIFYKDPKDAKrlspeersyiengqekhlNNAKKEKTSVINILKQRNFWGIG 233
Cdd:cd17490 140 GGLIAEHfGMRAPFLLAALAGVL-GFILSLFIKEERREK------------------KPVLTELKELLSVLKDKKLLFFS 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 234 isrFLADPAWGtINFWVPVFFVETLHFSL----KEIAMFVWLPFLMADLGCLASGFvaKFFNERGislinsRRITFTIGA 309
Cdd:cd17490 201 ---LLAILQQM-ITFSTTFGFTPLIAKQLgassFQLGLLSIIYLLPNALASLLSGT--LFYKKLG------ERNTIIIGF 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 310 ILMT-TIGLVSIIENPYIAVLLISIGGFSHQLLSTVAATLGADLFKKNEVATAVGMAGACAWSGQLIFNLFIGAFVSIIG 388
Cdd:cd17490 269 LLLGaYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFG 348
|
330 340
....*....|....*....|...
gi 545256359 389 FGPFFIALAVFDLIGAVALWILI 411
Cdd:cd17490 349 LQTGFFVIGVIALLAAILSLAYY 371
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
33-193 |
1.48e-04 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 43.85 E-value: 1.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 33 APTIMSDLGISKEQySWIVSVFQLAYTIG----QPIMGFFIDNIGLKLGFFICAVIWGLATMGHALTGSWMGLAFMRGIM 108
Cdd:TIGR00898 112 SSTIVTEWDLVCED-AWKVDLTQSCFFVGvllgSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLV 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 109 GVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLApPLIAWCIMFHSW-QFAFIVAGILAVIAAFI------W 181
Cdd:TIGR00898 191 GMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLL-PLVAYFIPDWRWlQLAVSLPTFLFFLLSWFvpesprW 269
|
170
....*....|..
gi 545256359 182 LIFYKDPKDAKR 193
Cdd:TIGR00898 270 LISQGRIEEALK 281
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
34-185 |
1.76e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 43.36 E-value: 1.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 34 PTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMG-FFIDNIGLKLGFFICAVIWGLATMGHALTGSWMGLAFMRGIMGVSE 112
Cdd:cd17490 219 PLIAKQLGASSFQLGLLSIIYLLPNALASLLSGtLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGT 298
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 545256359 113 ASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQFAFIVAGILAVIAAFIWLIFY 185
Cdd:cd17490 299 GILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSLAYY 371
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
26-199 |
2.79e-04 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 42.68 E-value: 2.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 26 RTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMGHALTGSWMGLAFMR 105
Cdd:cd06180 15 RFAYTPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 106 GIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFH-SWQFAFIVAGILAVIAAFI-WLI 183
Cdd:cd06180 95 FLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLGGGlSWRAGWLALALLSAVLLLLsFLL 174
|
170
....*....|....*.
gi 545256359 184 FYKDPKDAKRLSPEER 199
Cdd:cd06180 175 LRRGPSAPTEASAAES 190
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
93-182 |
3.39e-04 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 42.71 E-value: 3.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 93 ALTGSWMGLAFMRGIMGVSEASAIPAGVKTASTWFPAKERG-IATGVFnMGTSFGAMLAPPLIAWCIMFHSWQFAFIVAG 171
Cdd:cd17382 99 AARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSrLATTAF-CGSYAGAVVGMPLSGILVQYVGWSSPFYVYG 177
|
90
....*....|.
gi 545256359 172 ILAVIAAFIWL 182
Cdd:cd17382 178 VFGIIWYMFWM 188
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
32-199 |
5.94e-04 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 41.82 E-value: 5.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 32 AAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMGHALTGSWMGLAFMRGIMGVS 111
Cdd:PRK11102 13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 112 EASA---IPAGVKTAstwFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQFAFIVAGILAVIAAFiwLIFYKDP 188
Cdd:PRK11102 93 AAAAsvvINALMRDM---FPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAA--LVFFFIP 167
|
170
....*....|.
gi 545256359 189 KDakrLSPEER 199
Cdd:PRK11102 168 ET---LPKERR 175
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
56-409 |
7.01e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 41.74 E-value: 7.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 56 LAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATM------GHALTGSW--MGLAFMRGIMGVSEASAIPAGVKTASTWF 127
Cdd:cd17369 55 LARPLGGVVFGHFGDRIGRKKTLVLTLLLMGIATFligllpTYAQIGILapILLVLLRLLQGLALGGEWGGAVLMAVEHA 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 128 PAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHS--------WQFAFIVAGILAVIAAFIwlifykdpkdakRLSPEER 199
Cdd:cd17369 135 PPKRRGFYGSFPQLGAPVGLLLATGVFLLLSALLSdeaflswgWRIPFLLSAVLVAVGLYI------------RLRLEET 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 200 SYIENGQEKhlnnAKKEKTSVINILKQ--RNFWGIGISRFLADPAWGTINFWVPVFFVETLHFSLKEIAMFVWLPFLMAD 277
Cdd:cd17369 203 PVFRRAKEA----GQVVRAPLVEVLRRhwRALLLAIGLRLAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAA 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 278 LGCLASGFVAKFFnergislinSRRITFTIGAILMTTIG-----LVSIIENPYIAVLLISIGGFSHQLLSTVAATLGADL 352
Cdd:cd17369 279 ITIPLFGWLSDRV---------GRRPVYLAGALLAALFAfpffwLLDTGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAEL 349
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 545256359 353 FKKNEVATAVGMA---GACAWSGqliFNLFIGAFVSIIGFGPFFIA--LAVFDLIGAVALWI 409
Cdd:cd17369 350 FPTRVRYTGASLGyqlGAILGGG---FAPLIATALVAATGSWWPVAlyLAALAVISLVAALF 408
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
27-181 |
9.66e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 41.00 E-value: 9.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 27 TALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMGHALTGSWMG-LAFMR 105
Cdd:cd17477 205 GAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLaLLVLL 284
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 545256359 106 GIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQFAFIVAGILAVIAAFIW 181
Cdd:cd17477 285 FLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
52-188 |
1.07e-03 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 41.15 E-value: 1.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 52 SVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMGHALtGSWMGL------AFMRGIMGVSEASAIPAGVKTAST 125
Cdd:cd17344 69 SAFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFGL-GYYWNIhslwyfVVVQILAGLFQSTGWPSVVACVGN 147
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 545256359 126 WFPAKERGIATGVFNMGTSFGAMLApPLIAWCIMFHSWQFAFIVAGIL-AVIAAFIWLIFYKDP 188
Cdd:cd17344 148 WFGKGKRGLIMGIWNSHTSVGNILG-SLIAGIFVSSAWGLSFIVPGIIiAAMGVLVFLFLVEHP 210
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
34-407 |
1.67e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 40.30 E-value: 1.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 34 PTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLG----FFICAVIWGL---------ATMGHALTGSWMG 100
Cdd:cd17313 23 PPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGrrrpFILVGAPLAAlglilipnaADIGLALGDGPRT 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 101 LAFMRGIMGVS----EASAIPAGVKT-ASTWFPAKERGIATGVFNM--------GTSFGAMLAPPLIAWCIMFHSWQFAF 167
Cdd:cd17313 103 WALVLFVLGIVlldfAMNVCQGPVRAlLPDLVPPEQRSKANGIINFmgglggvlGYLLGAILWDHNWFGFALGGNLKVPF 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 168 IVAGILAVIAAFIWLIFYKDPKDAKRlspEERSYIENGQEKHLNNAKKEKTSvinilKQRNFWGIGISRFLADPAWGTIN 247
Cdd:cd17313 183 YIGAIILLVCVLVTLFFVKEPPLSPE---AGEHSENPSLGEVLKSLLKLLKI-----MPRSLLRLLLVIFFWWIAFFPFE 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 248 F----WV--PVFFVETLHFSLKEIA--MFVWLPFLMAdLGCLASGFVAKFFNERgisliNSRRITFTIGAILMT-TIGLV 318
Cdd:cd17313 255 LfftdYMgeEVYHGTSAASSHYGAGvrMGAWGLLIFS-LAFLIFSLPIGKLGKK-----IGRKKVYLIGLVLFAvGMALM 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 319 SIIENPYIAVLLISIGGFSHQLLSTVAATLGADLFKKNE--VATAVGMAGACAWSGQLIFNLFIGAFVSIIGFGPFFIAL 396
Cdd:cd17313 329 ALVHNVTVALVLFALGGIGWATININPYPLVSDYHSESGrgQGTDTGLLNLAISLAQILVSLLAGPIIDVKGYGTVFPVA 408
|
410
....*....|.
gi 545256359 397 AVFDLIGAVAL 407
Cdd:cd17313 409 AVASFLSLVGA 419
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
7-206 |
2.18e-03 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 40.35 E-value: 2.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 7 YRWQMIVLVCFITIINYLDRTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWG 86
Cdd:TIGR01299 164 FQWALFFVLGLALMADGVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNG 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 87 LATMGHALTGSWMGLAFMRGIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLiAWCIM------- 159
Cdd:TIGR01299 244 FFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIYAAAM-AWAIIphygwsf 322
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 545256359 160 -------FHSWQFaFIVAGILAVIAAFIWLIFYKDpkdakrlSPeeRSYIENGQ 206
Cdd:TIGR01299 323 qmgsayqFHSWRV-FVIVCAFPCVFAIGALTFMPE-------SP--RFFLENGK 366
|
|
| MFS_SLC18A3_VAChT |
cd17383 |
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ... |
63-198 |
3.18e-03 |
|
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340941 [Multi-domain] Cd Length: 378 Bit Score: 39.60 E-value: 3.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 63 PIMGFFIDNIGLKLGFFICAVIWGLATMGHALTGSWMGLAFMRGIMGVSEASAIPAGVKTASTWFPAK-ERGIATGVFNM 141
Cdd:cd17383 48 PFSGTLIDRVGYDIPMMIGLTVMFLSTAVFAFGESYAVLFFARSLQGVGSAFADTAGLAMIADRFTEEaERSKALGIALA 127
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 545256359 142 GTSFGAMLAPPLIAWCIMFHSWQFAFIVAGILAVIAAFIWLIFYKDPKDAKRLSPEE 198
Cdd:cd17383 128 FISFGCLVAPPFGGILYEFAGKEVPFLILAFVCLLDGLLLLLVMKPVRRETRANMPE 184
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
29-183 |
3.19e-03 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 39.48 E-value: 3.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 29 LGVAAPTIMSDLGI--SKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMGHALTGSWMGLAFMRG 106
Cdd:cd17315 16 INGALLYIAKDLGFglSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 107 IMGvseasaIPAGVKTASTWF------PAKERGIATGVFNMGTSFGAMLA--PPLIAWCIMFHSWQFAFIVAGILAVIAA 178
Cdd:cd17315 96 LLG------LGVGLASVLVPLyiseiaPAKIRGALGTLNQLMITFGILLAylLGLALSLSPPGWWRLMFALAAVPALLQL 169
|
....*
gi 545256359 179 FIWLI 183
Cdd:cd17315 170 LLMFF 174
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
301-413 |
3.89e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 39.10 E-value: 3.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 301 RRITFTIGAILM-TTIGLVSIIENPYIAVLLISIGGFSHQLLSTVAATLGADLFKKNEVATAVGMAGACAWSGQLIFNLF 379
Cdd:cd17325 60 RKRLLLLGLLLLaVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLL 139
|
90 100 110
....*....|....*....|....*....|....
gi 545256359 380 IGAFVSIIGFGPFFIALAVFDLIGAVALWILIKD 413
Cdd:cd17325 140 GGLLADALGYRAPFLVCAALALLALVLALLLLPE 173
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
12-179 |
3.94e-03 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 39.18 E-value: 3.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 12 IVLVCFITIINYLDRTALGVAAPTIMSDL-GISKEQYSWIVSVFQLAYTIGQPIMGFFID-----NIGLKLGFFICAVIW 85
Cdd:cd17312 185 VWVLSLAYAFVYIVRYACLDWGPLYLYEVkGYSLIDAGWFSSLYEVGGIAGTILAGLLSDklfggRRAPIAVIYMLLMTL 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 86 GLATMGHALTGSWM--GLAFMRG------IMGVSEASAIPAGVKTAStwfpakerGIATGVFNMGTSFGAMLAPPLIAWC 157
Cdd:cd17312 265 SLALFWFFPHNKLLsiVLLFLIGffvggpINLIGGAAAQDIGRKEAA--------GTATGFVGLFGYLGASLAGLPLGYI 336
|
170 180
....*....|....*....|....*
gi 545256359 158 IMFHSW---QFAFIVAGILAVIAAF 179
Cdd:cd17312 337 IDHYGWstvFYFLISAALLSVLLLL 361
|
|
| MFS_FLVCR_like |
cd17398 |
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ... |
7-154 |
4.41e-03 |
|
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340956 [Multi-domain] Cd Length: 406 Bit Score: 39.14 E-value: 4.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 7 YRWQMIVLVCFITIINYLDRTALGVAAPTIMSDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAviwG 86
Cdd:cd17398 1 RRWIMLFLFCLYSMSNAFQWIQYAIISNIIVDYYGVSDTAVDWTSMIYMLTYIPLIFPATWLLEKYGLRVTVLLGS---F 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 87 LATMGHAL-------TGSWMGLAFmRGIMGVSEAS--AIPAgvKTASTWFPAKERGIAT--GVF--NMGTSFGAMLAPPL 153
Cdd:cd17398 78 LNCLGAWLklfssspDLFWVAMAG-QTICALAQVFilGIPP--RLAAVWFGPDEVSTATaiGVFgnQLGVALGFVLPPLL 154
|
.
gi 545256359 154 I 154
Cdd:cd17398 155 V 155
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
9-184 |
5.33e-03 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 38.82 E-value: 5.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 9 WQMIVLVCFITIINYLDRTALGVAAPTIM-SDLGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLK---LGFFICAVI 84
Cdd:cd17367 222 PRELLLVVGLTAGGTLAFYTWTTYLQKFLvNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRpllLFFGIGGTL 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 85 --WGLATMGHALTGSWM-------GLAFMRG---IMGVSEASAIPAGVKTASTWFPakeRGIATGVFNmGTsfgamlAPP 152
Cdd:cd17367 302 atVPLLSALDHTDSPYTafalvlvGLVFLSGytsINAVVKAELFPTHVRALGVGLP---YALAVAIFG-GT------APY 371
|
170 180 190
....*....|....*....|....*....|...
gi 545256359 153 LIAWCI-MFHSWQFAFIVAGiLAVIAAFIWLIF 184
Cdd:cd17367 372 VALWLKsIGHEWVFFWYVAG-LIAISLVVYLRM 403
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
11-185 |
5.35e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 38.75 E-value: 5.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 11 MIVLVCFITIINYLDRTALGVAAPTIMSD-LGISKEQYSWIVSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLAT 89
Cdd:cd17329 201 AFLLFLLASFLISLIYFQLESTLPVYVVEiLGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGF 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 90 MGHALTGSWMGLAFMRGIMGVSEASAIPAGVKTASTWFPAKERGIATGVFNMGTSFGAMLAPPLIAWCIMFHSWQFAFIV 169
Cdd:cd17329 281 AVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLI 360
|
170
....*....|....*.
gi 545256359 170 AGILAVIAAFIWLIFY 185
Cdd:cd17329 361 LAALGLIAAALLLGLQ 376
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
51-182 |
5.94e-03 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 38.55 E-value: 5.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 51 VSVFQLAYTIGQPIMGFFIDNIGLKLG-----FFICAViwGLATMGHALTGSWMGLAFMRGIMGVSEASAIPAGVKTAST 125
Cdd:cd17314 248 MSIYGLFNAFGRLLWGIVADFFGGRLStlsilLTILGL--GLCAFLFLLKMTPVGLVLTGSLLGFSYGGLFTVYPATVST 325
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 545256359 126 WFPAKERGIATGVFNMGTSFGAMLAPPLIAWCI-MFHSWQFAFIVAGILAVIAAFIWL 182
Cdd:cd17314 326 VFGTESFATLYGILLFAPAIGSILGPMLGAKFYdRTPSYISAVYIYAVIVFLASAILL 383
|
|
| PLN00028 |
PLN00028 |
nitrate transmembrane transporter; Provisional |
34-187 |
6.17e-03 |
|
nitrate transmembrane transporter; Provisional
Pssm-ID: 177665 [Multi-domain] Cd Length: 476 Bit Score: 38.75 E-value: 6.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 34 PTIMSDLGISKEQYsWIVSVFQLAYTIGQPI-MGFFIDNIGLKLGFFICAVIWGLATMGHALTGSWMGLAFMRGIMGVSE 112
Cdd:PLN00028 60 PIIRDNLNLTKSDI-GNAGIASVSGSIFSRLaMGPVCDLYGPRYGSAFLLMLTAPAVFCMSLVSSATGFIAVRFFIGFSL 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 113 ASAIPAGVKTaSTWFPAKERGIATGVF----NMGTSFGAMLAP---PLIAWCIM--FHSWQFAFIVAGILAVIAAFIWLI 183
Cdd:PLN00028 139 ATFVSCQYWM-STMFNGKIVGTANGIAagwgNLGGGVTQLLMPlvfPLIKDAGApsFTAWRIAFFVPGLLHIIMGILVLT 217
|
....
gi 545256359 184 FYKD 187
Cdd:PLN00028 218 LGQD 221
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
51-408 |
8.30e-03 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 38.35 E-value: 8.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 51 VSVFQLAYTIGQPIMGFFIDNIGLKLGFFICAVIWGLATMGHALTGSWMGLAFMRGIMGvseASAIPAGVKT-ASTWFPA 129
Cdd:cd17472 38 LGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQG---SGAISSVVMAlLADLTRE 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 130 KERGIATGVfnMGTSFG-----AMLAPPLIAWCIMFHSwqfAFIVAGILAVIAAFIWLIFYKDPKdakrlspeersyien 204
Cdd:cd17472 115 ENRTKAMAL--IGASIGiafaiSMVLGPLLAAHLGVSG---LFLITAILSLVSLLILLFFVPDPP--------------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 205 gqeKHLNNAKKEKTSVINILKQRNFWGIGISRFLadpawgtinfwvpvffvetLHFSLkeIAMFVWLPFLMADLGC---- 280
Cdd:cd17472 175 ---KIVQISEKEKKKLKKLLKNKRLLRLDFSIFI-------------------LHFVL--MAFFYILPLLLTQLGGgkgq 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545256359 281 --------LASGFVAKFFNERGISLINSRRITFTIGAILMTTIGLVSIIENPYIAVLLISIGGF--SHQLLSTVAATLGA 350
Cdd:cd17472 231 lwkvylpaILIGFILMVPFVIYAEKKGKMKQVFVSSILLIAVGFLLLLFAATSLWLLIIGLIIFfiGFNLLEALLPSLVS 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 545256359 351 DLFKKNEVATAVGMAGACAWSGQLIFNLFIGAFVSIIGFG---PFFIALAVFDLIGAVALW 408
Cdd:cd17472 311 KIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSsvfLTILILALLWLLVSFLLP 371
|
|
| |
