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Conserved domains on  [gi|544968103|ref|WP_021371561|]
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MULTISPECIES: ClbS/DfsB family four-helix bundle protein [Clostridia]

Protein Classification

ClbS/DfsB family four-helix bundle protein( domain architecture ID 10547130)

ClbS/DfsB family four-helix bundle protein similar to Paenibacillus dendritiformis sibling lethal factor precursor (DfsB), which adopts a non-enzymatic variant of the DinB fold; proteolytic processing of DfsB produces sibling bacteriocin, also called sibling lethal factor (Slf), which inhibits sibling bacterial colonies

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF1706 pfam08020
Protein of unknown function (DUF1706); This family contains many hypothetical proteins from ...
 2-169 1.28e-75

Protein of unknown function (DUF1706); This family contains many hypothetical proteins from bacteria and yeast.


:

Pssm-ID: 429789  Cd Length: 162  Bit Score: 223.21  E-value: 1.28e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544968103    2 RVYENKEELKTEINKTFEKYIVEFDNIPESLKDKRIDEVDRTPAENLAYQVGWTTLVLKWEEDERNGLQVKTPSDEFKWN 81
Cdd:pfam08020   1 ARPTSKEELIEAINKNFEKLIALIDSIPEELKDGAHWGRDKSPRDVLAHLYGWHKLLLKWEEDEQEGLTVFFPAPGYKWN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544968103   82 QLGELYQWFTDTYAYLSLQELKSKLNENINSIYVMIDSLSDEELFKPHMRKWaddatkTAVWEVYKFIHVNTVAPFKTFR 161
Cdd:pfam08020  81 QLGELNQSFYKKYQDTSLEELLALLKESHQRIMALIESFSDEELFTKGGRKW------TGTWTLGRYIHSNTSSPYDWAR 154


                  ....*...
gi 544968103  162 NKIRKWKK 169
Cdd:pfam08020 155 KKIRKWKK 162
 
Name Accession Description Interval E-value
DUF1706 pfam08020
Protein of unknown function (DUF1706); This family contains many hypothetical proteins from ...
 2-169 1.28e-75

Protein of unknown function (DUF1706); This family contains many hypothetical proteins from bacteria and yeast.


Pssm-ID: 429789  Cd Length: 162  Bit Score: 223.21  E-value: 1.28e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544968103    2 RVYENKEELKTEINKTFEKYIVEFDNIPESLKDKRIDEVDRTPAENLAYQVGWTTLVLKWEEDERNGLQVKTPSDEFKWN 81
Cdd:pfam08020   1 ARPTSKEELIEAINKNFEKLIALIDSIPEELKDGAHWGRDKSPRDVLAHLYGWHKLLLKWEEDEQEGLTVFFPAPGYKWN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544968103   82 QLGELYQWFTDTYAYLSLQELKSKLNENINSIYVMIDSLSDEELFKPHMRKWaddatkTAVWEVYKFIHVNTVAPFKTFR 161
Cdd:pfam08020  81 QLGELNQSFYKKYQDTSLEELLALLKESHQRIMALIESFSDEELFTKGGRKW------TGTWTLGRYIHSNTSSPYDWAR 154


                  ....*...
gi 544968103  162 NKIRKWKK 169
Cdd:pfam08020 155 KKIRKWKK 162
DfsB COG4283
Uncharacterized conserved protein DfsB/IRC4, DUF1706 (PF08020) domain [General function ...
 2-169 5.58e-73

Uncharacterized conserved protein DfsB/IRC4, DUF1706 (PF08020) domain [General function prediction only];


Pssm-ID: 443424  Cd Length: 167  Bit Score: 216.66  E-value: 5.58e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544968103   2 RVYENKEELKTEINKTFEKYIVEFDNIPESLKDKRIDE--VDRTPAENLAYQVGWTTLVLKWEEDERNGLQVKTPSDEFK 79
Cdd:COG4283    1 PRPTSKEELLEAINKNFEKLIALLDSIPEEEADEPFDFggRDRSVRDVLAHLIGWHELLLKWYEDEQAGEPVDFPAEGYK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544968103  80 WNQLGELYQWFTDTYAYLSLQELKSKLNENINSIYVMIDSLSDEELFKPHMRKWaddatkTAVWEVYKFIHVNTVAPFKT 159
Cdd:COG4283   81 WNTLGELNQKFYAKYQDLSLEELLALLNASHQEILALIESLSDEELFGKKRRPW------TGKWTLGRYIQSNTSSPYDW 154

                        170
                 ....*....|
gi 544968103 160 FRNKIRKWKK 169
Cdd:COG4283  155 ARKKIRKWKK 164
 
Name Accession Description Interval E-value
DUF1706 pfam08020
Protein of unknown function (DUF1706); This family contains many hypothetical proteins from ...
 2-169 1.28e-75

Protein of unknown function (DUF1706); This family contains many hypothetical proteins from bacteria and yeast.


Pssm-ID: 429789  Cd Length: 162  Bit Score: 223.21  E-value: 1.28e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544968103    2 RVYENKEELKTEINKTFEKYIVEFDNIPESLKDKRIDEVDRTPAENLAYQVGWTTLVLKWEEDERNGLQVKTPSDEFKWN 81
Cdd:pfam08020   1 ARPTSKEELIEAINKNFEKLIALIDSIPEELKDGAHWGRDKSPRDVLAHLYGWHKLLLKWEEDEQEGLTVFFPAPGYKWN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544968103   82 QLGELYQWFTDTYAYLSLQELKSKLNENINSIYVMIDSLSDEELFKPHMRKWaddatkTAVWEVYKFIHVNTVAPFKTFR 161
Cdd:pfam08020  81 QLGELNQSFYKKYQDTSLEELLALLKESHQRIMALIESFSDEELFTKGGRKW------TGTWTLGRYIHSNTSSPYDWAR 154


                  ....*...
gi 544968103  162 NKIRKWKK 169
Cdd:pfam08020 155 KKIRKWKK 162
DfsB COG4283
Uncharacterized conserved protein DfsB/IRC4, DUF1706 (PF08020) domain [General function ...
 2-169 5.58e-73

Uncharacterized conserved protein DfsB/IRC4, DUF1706 (PF08020) domain [General function prediction only];


Pssm-ID: 443424  Cd Length: 167  Bit Score: 216.66  E-value: 5.58e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544968103   2 RVYENKEELKTEINKTFEKYIVEFDNIPESLKDKRIDE--VDRTPAENLAYQVGWTTLVLKWEEDERNGLQVKTPSDEFK 79
Cdd:COG4283    1 PRPTSKEELLEAINKNFEKLIALLDSIPEEEADEPFDFggRDRSVRDVLAHLIGWHELLLKWYEDEQAGEPVDFPAEGYK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544968103  80 WNQLGELYQWFTDTYAYLSLQELKSKLNENINSIYVMIDSLSDEELFKPHMRKWaddatkTAVWEVYKFIHVNTVAPFKT 159
Cdd:COG4283   81 WNTLGELNQKFYAKYQDLSLEELLALLNASHQEILALIESLSDEELFGKKRRPW------TGKWTLGRYIQSNTSSPYDW 154

                        170
                 ....*....|
gi 544968103 160 FRNKIRKWKK 169
Cdd:COG4283  155 ARKKIRKWKK 164
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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