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Conserved domains on  [gi|544825605|ref|WP_021241603|]
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MULTISPECIES: type 1 fimbria D-mannose specific adhesin FimH [Enterobacter]

Protein Classification

fimbrial protein( domain architecture ID 646)

fimbrial protein similar to the type-1 fimbrial major subunit FimA, which is transported to the outer membrane by the lipoprotein sorting system, and a mature or processed FimA protein on the outer membrane is autopolymerized to form Fim fimbriae

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fimbrial super family cl01416
Fimbrial protein;
23-335 0e+00

Fimbrial protein;


The actual alignment was detected with superfamily member PRK15199:

Pssm-ID: 445401  Cd Length: 335  Bit Score: 564.53  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544825605  23 TVCVNEKGVPTEVHYDLTDKFNSSNNQIGQVVTLSEKSQWVGVNAVCPKGTVGNTTKRSYVTDYQVTGTSDGYQYLKLND 102
Cdd:PRK15199  23 TVCANSTGVAEDEHYDLSNVFNSTNNQPGQIVTLPEKSGWVGVNAICPPGTLVNYTYRSYVTNFPVQETIDNYKYMKLND 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544825605 103 YLDGAMKITDSYAGVFYPPKNYIQMGSHPNVSKNRPFGVQDSSLVFRLKVTRRFINMVVIPRATMFRVYVTTTSSDPLTT 182
Cdd:PRK15199 103 YLLGAMSIVDSVAGIFYPPQNYIRMGTDPNVSQNLPFGVMDSKLIFRLKVIRPFINMVEIPRQTMFTVYVTTTPYDPLVT 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544825605 183 PVYTISYSGTIQVPQSCAINAGNVVEFDFGDIGASLFSKAGVGNKPEGVSSQSKTIAIKCTNVEANAMLTMRVEAEKVSD 262
Cdd:PRK15199 183 PVYTISYSGRVEVPQNCELNAGQVVEFDFGDIGASLFSQAGAGNRPQGVMPQTKTIAIKCTNVAAQAYLTMRLEAEKVSG 262

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 544825605 263 NVLVSDNPDVGFIIANESGAPLTPNNLTSKIPFRLDDSAQAKVGIRVWPVSVTGNKPAEGRFTSRGYLRVDYD 335
Cdd:PRK15199 263 QAMVSDNPDLGFIVADQNGTPLTPNNLNSKIPFRLDDAAAANVGIRAWPISITGQKPTEGPFTARGYLRVDYD 335
 
Name Accession Description Interval E-value
fimH PRK15199
type 1 fimbrin D-mannose specific adhesin FimH;
23-335 0e+00

type 1 fimbrin D-mannose specific adhesin FimH;


Pssm-ID: 237921  Cd Length: 335  Bit Score: 564.53  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544825605  23 TVCVNEKGVPTEVHYDLTDKFNSSNNQIGQVVTLSEKSQWVGVNAVCPKGTVGNTTKRSYVTDYQVTGTSDGYQYLKLND 102
Cdd:PRK15199  23 TVCANSTGVAEDEHYDLSNVFNSTNNQPGQIVTLPEKSGWVGVNAICPPGTLVNYTYRSYVTNFPVQETIDNYKYMKLND 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544825605 103 YLDGAMKITDSYAGVFYPPKNYIQMGSHPNVSKNRPFGVQDSSLVFRLKVTRRFINMVVIPRATMFRVYVTTTSSDPLTT 182
Cdd:PRK15199 103 YLLGAMSIVDSVAGIFYPPQNYIRMGTDPNVSQNLPFGVMDSKLIFRLKVIRPFINMVEIPRQTMFTVYVTTTPYDPLVT 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544825605 183 PVYTISYSGTIQVPQSCAINAGNVVEFDFGDIGASLFSKAGVGNKPEGVSSQSKTIAIKCTNVEANAMLTMRVEAEKVSD 262
Cdd:PRK15199 183 PVYTISYSGRVEVPQNCELNAGQVVEFDFGDIGASLFSQAGAGNRPQGVMPQTKTIAIKCTNVAAQAYLTMRLEAEKVSG 262

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 544825605 263 NVLVSDNPDVGFIIANESGAPLTPNNLTSKIPFRLDDSAQAKVGIRVWPVSVTGNKPAEGRFTSRGYLRVDYD 335
Cdd:PRK15199 263 QAMVSDNPDLGFIVADQNGTPLTPNNLNSKIPFRLDDAAAANVGIRAWPISITGQKPTEGPFTARGYLRVDYD 335
Fimbrial pfam00419
Fimbrial protein;
187-335 2.28e-20

Fimbrial protein;


Pssm-ID: 425671  Cd Length: 152  Bit Score: 85.95  E-value: 2.28e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544825605  187 ISYSGTI-QVPQSCAINAGNVVEFDFGDIGASLFSKAGVGNkpegvSSQSKTIAIKCTNVEANAMLTMRVEAEK--VSDN 263
Cdd:pfam00419   1 INFTGTVtRVPATCKITAGTPIEVDFGQIPVNELNAGGEGS-----RQKPFSITLECSSGSSAVKVTVGLFGTAdaSSPN 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 544825605  264 VLVSDN-----PDVGFIIANESGAPLTPNNLTSKIPFRLDDSAQAKVGIRVWPVSVTGNKPAEGRFTSRGYLRVDYD 335
Cdd:pfam00419  76 LLLTGNgagaaTGVGIRLYDANGGALPPNNGTSSIPVSATAAVATGITFTASLVATTGGTPTAGDFNATATIVVDYQ 152
FimA COG3539
Pilin (type 1 fimbrial protein) [Cell motility];
176-335 2.50e-14

Pilin (type 1 fimbrial protein) [Cell motility];


Pssm-ID: 442760 [Multi-domain]  Cd Length: 172  Bit Score: 70.07  E-value: 2.50e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544825605 176 SSDPLTTPVYTISYSGTIqVPQSCAINAGNV-VEFDFGDIGASLFSKAGvgnkpEGVSSQSKTIAIK-CTNVEANAmLTM 253
Cdd:COG3539   15 SAAAAAAADGTVNFTGTV-VAPTCTINTGSKdQTVDLGTVSTSDLNGVG-----STSGPKPFSIKLTnCDAGTSNS-VKV 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544825605 254 RVEAEKVSDN--VLV----SDNPDVGFIIANESGAPLTPNNLTSKIPfrLDDSAQAKVGIRVWPVSvTGNKPAEGRFTSR 327
Cdd:COG3539   88 TFTGTADSANpgLLAntgsGGASGVGIQLLDSDGTPIPLGTPSSAVT--LTSNGSATLPFYARYVA-TGATVTAGSFNAT 164


                 ....*...
gi 544825605 328 GYLRVDYD 335
Cdd:COG3539  165 ATFTIDYQ 172
 
Name Accession Description Interval E-value
fimH PRK15199
type 1 fimbrin D-mannose specific adhesin FimH;
23-335 0e+00

type 1 fimbrin D-mannose specific adhesin FimH;


Pssm-ID: 237921  Cd Length: 335  Bit Score: 564.53  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544825605  23 TVCVNEKGVPTEVHYDLTDKFNSSNNQIGQVVTLSEKSQWVGVNAVCPKGTVGNTTKRSYVTDYQVTGTSDGYQYLKLND 102
Cdd:PRK15199  23 TVCANSTGVAEDEHYDLSNVFNSTNNQPGQIVTLPEKSGWVGVNAICPPGTLVNYTYRSYVTNFPVQETIDNYKYMKLND 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544825605 103 YLDGAMKITDSYAGVFYPPKNYIQMGSHPNVSKNRPFGVQDSSLVFRLKVTRRFINMVVIPRATMFRVYVTTTSSDPLTT 182
Cdd:PRK15199 103 YLLGAMSIVDSVAGIFYPPQNYIRMGTDPNVSQNLPFGVMDSKLIFRLKVIRPFINMVEIPRQTMFTVYVTTTPYDPLVT 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544825605 183 PVYTISYSGTIQVPQSCAINAGNVVEFDFGDIGASLFSKAGVGNKPEGVSSQSKTIAIKCTNVEANAMLTMRVEAEKVSD 262
Cdd:PRK15199 183 PVYTISYSGRVEVPQNCELNAGQVVEFDFGDIGASLFSQAGAGNRPQGVMPQTKTIAIKCTNVAAQAYLTMRLEAEKVSG 262

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 544825605 263 NVLVSDNPDVGFIIANESGAPLTPNNLTSKIPFRLDDSAQAKVGIRVWPVSVTGNKPAEGRFTSRGYLRVDYD 335
Cdd:PRK15199 263 QAMVSDNPDLGFIVADQNGTPLTPNNLNSKIPFRLDDAAAANVGIRAWPISITGQKPTEGPFTARGYLRVDYD 335
PRK15189 PRK15189
fimbrial protein BcfD; Provisional
 24-335 1.76e-85

fimbrial protein BcfD; Provisional


Pssm-ID: 185111 [Multi-domain]  Cd Length: 335  Bit Score: 261.21  E-value: 1.76e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544825605  24 VCVNEKGVPTEVHYDLTDKFNSSNNQIGQVVTLsEKSQWVGVNAVCPKGTVG-NTTKRSYVTDYQVTGTSDGYQYLKLN- 101
Cdd:PRK15189  23 VCKNVNGVPSSINYDLTTTLTAEQNQVGKTVQL-EKSQEVNVQAVCPAGASTySQTYRSYVSPYPVVETSGNWKYLKLDp 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544825605 102 DYLDGAMKITDSYAGVFYPPKNYIQMGSHPNVSKNRPFGVQDSSLVFRLKVTRRFINMVVIPRATMFRVYVTTTSSDPLT 181
Cdd:PRK15189 102 DYLEGGMRIEDSSAGDIYPPMNNVLMGYDENVKAGQPFYVRDSNLEFQLKIVKPFVGTVNISPKTMFNVYVMTAAGDPLT 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544825605 182 TPVYTISYSGTIQVPQSCAINAGNVVEFDFGDIGASLFSKAgvGNKPEGVSSQSKTIAIKCTNVEANAMLTMRVEAEKVS 261
Cdd:PRK15189 182 DVVYSILYSGTVTVPQSCEINAGQTILVNFGALYSGNFNHA--GQKPEGVRAKKFSVPVKCSGLDSQVNLTMRLIATPDS 259

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 544825605 262 D--NVLVSDNPDVGFIIANESGAPLTPNNLTSKIPFRLDDSAQAKVGIRVWPVSVTGNKPAEGRFTSRGYLRVDYD 335
Cdd:PRK15189 260 HvpQAIASDNADVGVVVETDEGNALIPNDVQSVAPFITDSAGRANITLQAYPVSTTGETPAEGAFTALASLRVDFD 335
PRK15206 PRK15206
long polar fimbrial protein LpfD; Provisional
 69-333 1.13e-22

long polar fimbrial protein LpfD; Provisional


Pssm-ID: 237924 [Multi-domain]  Cd Length: 359  Bit Score: 96.96  E-value: 1.13e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544825605  69 CP-KGTVGNTTKRSYVTDYQVTGTSDGYQYLKLNDYLDGAMKITDSYAGVFYPPKNYIQMGS--------HPNVSKNRPF 139
Cdd:PRK15206  78 CPdDTSLINDTYFKAVVPLAFVTNIESRSYYQINNNIAIASDVLVSGGRGEYVNTPFENVGNltanrsqcTQNASSKDAI 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544825605 140 GVQDSSLVFRLKVTRRFINMVVIPRATMFRVYVTTTSSDPLTTPVYTISYSGTIQVPQSCAINAGNVVEFDFGDIGASLF 219
Cdd:PRK15206 158 WTTGGKGHLSLYILHPFVGESIIPSTKIMDLFGTKKPSVYNSIPAASVYISGSITVPQGCELSSGSTLEIPFGEFKATDF 237

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544825605 220 sKAGVGNKPEGVSSQSKTIAIKCTNVEANAMLTMRVEAEKVSD--NVLVSDNPDVGFIIANESGAPLTPNNLTSKIPFRL 297
Cdd:PRK15206 238 -KDRKGQVAKNATKFTKELQFKCTNISDGVKIFLRIEGMPNANdsNAIDMGNPDIGAVIEGANGKILVPNDASVNQELSV 316

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 544825605 298 -----DDSAQAKVGIRVWPVSVTGNKPAEGRFTSRGYLRVD 333
Cdd:PRK15206 317 sglvdDTHRTASTTISAYPISTTGKLPAAGDFEGIATMRID 357
Fimbrial pfam00419
Fimbrial protein;
187-335 2.28e-20

Fimbrial protein;


Pssm-ID: 425671  Cd Length: 152  Bit Score: 85.95  E-value: 2.28e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544825605  187 ISYSGTI-QVPQSCAINAGNVVEFDFGDIGASLFSKAGVGNkpegvSSQSKTIAIKCTNVEANAMLTMRVEAEK--VSDN 263
Cdd:pfam00419   1 INFTGTVtRVPATCKITAGTPIEVDFGQIPVNELNAGGEGS-----RQKPFSITLECSSGSSAVKVTVGLFGTAdaSSPN 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 544825605  264 VLVSDN-----PDVGFIIANESGAPLTPNNLTSKIPFRLDDSAQAKVGIRVWPVSVTGNKPAEGRFTSRGYLRVDYD 335
Cdd:pfam00419  76 LLLTGNgagaaTGVGIRLYDANGGALPPNNGTSSIPVSATAAVATGITFTASLVATTGGTPTAGDFNATATIVVDYQ 152
PRK15297 PRK15297
fimbrial protein;
149-332 1.10e-14

fimbrial protein;


Pssm-ID: 185197 [Multi-domain]  Cd Length: 359  Bit Score: 74.00  E-value: 1.10e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544825605 149 RLKVTRRFINMVVIPRATMFRVYVTTT---SSD---PLTTPVYTISYSGTIQVPQSCAINAGNVVEFDFGDIGASLFSKA 222
Cdd:PRK15297 169 RIYITHPLVGEITIPETTIMNLYLSKTpgsSGDnipPSVPPMAHVTMSGTITVPQSCSINAGQVIEVRLPDIEGKDIRHL 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544825605 223 GVGNKPEGVSSQsktIAIKCTNVEANAMLTMRVEAEKVSDN--VLVSDNPDVGFIIANESGAPLTPNNlTSKIPFRLDDS 300
Cdd:PRK15297 249 GDSPQNSHVTTQ---VNFTCSNVADGTNLSMSLNGATDPHNpdYLKTDNENLGIRISDKYDNTIVPGG-SAELPIEDYTD 324

                        170       180       190
                 ....*....|....*....|....*....|..
gi 544825605 301 AQAKVGIRVWPVSVTGNKPAEGRFTSRGYLRV 332
Cdd:PRK15297 325 GKGSTEFTAAPVNTTGHVPHTGEYQATATLEI 356
FimA COG3539
Pilin (type 1 fimbrial protein) [Cell motility];
176-335 2.50e-14

Pilin (type 1 fimbrial protein) [Cell motility];


Pssm-ID: 442760 [Multi-domain]  Cd Length: 172  Bit Score: 70.07  E-value: 2.50e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544825605 176 SSDPLTTPVYTISYSGTIqVPQSCAINAGNV-VEFDFGDIGASLFSKAGvgnkpEGVSSQSKTIAIK-CTNVEANAmLTM 253
Cdd:COG3539   15 SAAAAAAADGTVNFTGTV-VAPTCTINTGSKdQTVDLGTVSTSDLNGVG-----STSGPKPFSIKLTnCDAGTSNS-VKV 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544825605 254 RVEAEKVSDN--VLV----SDNPDVGFIIANESGAPLTPNNLTSKIPfrLDDSAQAKVGIRVWPVSvTGNKPAEGRFTSR 327
Cdd:COG3539   88 TFTGTADSANpgLLAntgsGGASGVGIQLLDSDGTPIPLGTPSSAVT--LTSNGSATLPFYARYVA-TGATVTAGSFNAT 164


                 ....*...
gi 544825605 328 GYLRVDYD 335
Cdd:COG3539  165 ATFTIDYQ 172
PRK15291 PRK15291
fimbrial protein StgD; Provisional
 91-326 1.40e-11

fimbrial protein StgD; Provisional


Pssm-ID: 185191 [Multi-domain]  Cd Length: 355  Bit Score: 64.76  E-value: 1.40e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544825605  91 TSDGYQYLKLNDYLDGAMKITDSYAGVFYPPknyiqMGSHPNVSKNRPFGVQD------------SSLVFRLKVTRRFIN 158
Cdd:PRK15291  98 TRNGYTYYTLNDNLSIATSIAVLGRGFIAVP-----FEAEPNVVKDGMNCYTDtvegnlatlytgSEVKVSFLINKPFVG 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544825605 159 MVVIPRATMFRVY--VTTTSSDPLTTPVYTISYSGTIQVPQSCAINAGNVVEFDFGDIGASLFS----KAGVGNKpegvs 232
Cdd:PRK15291 173 QVAIPGTIVANLYggLDASSSTASTDKLAEVRIVGDIVAPQSCEIDSGQVIEVNFGKIPVADFSttqgTAAAGHK----- 247

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544825605 233 sQSKTIAIKCTNVEANAMLTMRVEAEKV--SDNVL-VSDNPDVGFIIAN--ESGAPLTPNNLTSKIPFRLDDSAQAKVGI 307
Cdd:PRK15291 248 -VTKTVQVKCTGMLDENIVYSTFNADPVdsSANMMkVLGNDDVGIMIYDkwDRMVKVTGGKMDMDMGVNNGGAETNSLTF 326

                        250
                 ....*....|....*....
gi 544825605 308 RVWPVSVTGNKPAEGRFTS 326
Cdd:PRK15291 327 SAAPASATGARPQPGTFEA 345
PRK15276 PRK15276
putative fimbrial subunit SteE; Provisional
 187-334 1.70e-04

putative fimbrial subunit SteE; Provisional


Pssm-ID: 185179  Cd Length: 153  Bit Score: 41.25  E-value: 1.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544825605 187 ISYSGTIQVPQSCAINAGNVVEFDFGDIgaslfskagVGNKPEGVSSQSKT-IAIKCTNVEANAMLTMRVE----AEKVS 261
Cdd:PRK15276  17 LTFHGKLINPPACTINNGETLEVSFGSV---------IIDNIDGVNYLTEIpWTLTCDSSFRDDALTFTLSylgtATPYS 87

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 544825605 262 DNVLVSDNPDVGfIIANESGAPLTPNNltskiPFRLDDSAQAKvgIRVWPVSVTGNKPAEGRFTSRGYLRVDY 334
Cdd:PRK15276  88 AKALTTNVPELG-IELQQNGTVFPPGT-----SLTINESSLPT--LKAVPVKQPGKEPAEGDFEAFATLQVDY 152
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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