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Conserved domains on  [gi|543996329|ref|WP_021034569|]
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glycosyltransferase family 2 protein [Haemophilus influenzae]

Protein Classification

glycosyltransferase family 2 protein( domain architecture ID 10118426)

glycosyltransferase family 2 protein catalyzes the transfer of saccharide moieties from a donor to an acceptor to form glycosidic bonds

CATH:  3.90.550.10
CAZY:  GT2
EC:  2.4.-.-
Gene Ontology:  GO:0016757|GO:0006486
PubMed:  9445404|12691742|10508766|12200473|10521532
SCOP:  3000077

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 3-232 1.45e-94

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


:

Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 277.25  E-value: 1.45e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543996329   3 TISVAMIIKNEAQDLANCLDTVKDWVDEIIILDSGSTDNTKEIALSYGAKFYENSnWQGFGKQRQLAQQYVTSDYVLWLD 82
Cdd:cd02511    1 TLSVVIITKNEERNIERCLESVKWAVDEIIVVDSGSTDRTVEIAKEYGAKVYQRW-WDGFGAQRNFALELATNDWVLSLD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543996329  83 ADERVTLKLQQAILSAVKNDREnTVYEIPRVSEVFGREIRHSGWYPDYVVRLYRTNYAQYNDSLVHEKVEFPAGTKVEkL 162
Cdd:cd02511   80 ADERLTPELADEILALLATDDY-DGYYVPRRNFFLGRWIRHGGWYPDRQLRLFRRGKARFEDGRVHEQVVVDGGVGIV-L 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 543996329 163 TGDLEHFTYKSIHHYLVKSAGYAKAWADQRQAKGKKATLWQGISHA--LGCFVKMYLLKAGFLDGKQGFLLA 232
Cdd:cd02511  158 KGDILHYGYKSLEEFLEKHNRYSSLEAKDLAAKGKKRSLLKGLLLGrpLLAFLKMYILKRGFLDGRAGFILA 229
 
Name Accession Description Interval E-value
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 3-232 1.45e-94

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 277.25  E-value: 1.45e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543996329   3 TISVAMIIKNEAQDLANCLDTVKDWVDEIIILDSGSTDNTKEIALSYGAKFYENSnWQGFGKQRQLAQQYVTSDYVLWLD 82
Cdd:cd02511    1 TLSVVIITKNEERNIERCLESVKWAVDEIIVVDSGSTDRTVEIAKEYGAKVYQRW-WDGFGAQRNFALELATNDWVLSLD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543996329  83 ADERVTLKLQQAILSAVKNDREnTVYEIPRVSEVFGREIRHSGWYPDYVVRLYRTNYAQYNDSLVHEKVEFPAGTKVEkL 162
Cdd:cd02511   80 ADERLTPELADEILALLATDDY-DGYYVPRRNFFLGRWIRHGGWYPDRQLRLFRRGKARFEDGRVHEQVVVDGGVGIV-L 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 543996329 163 TGDLEHFTYKSIHHYLVKSAGYAKAWADQRQAKGKKATLWQGISHA--LGCFVKMYLLKAGFLDGKQGFLLA 232
Cdd:cd02511  158 KGDILHYGYKSLEEFLEKHNRYSSLEAKDLAAKGKKRSLLKGLLLGrpLLAFLKMYILKRGFLDGRAGFILA 229
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 1-156 4.15e-22

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 90.53  E-value: 4.15e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543996329   1 MPTISVAMIIKNEAQDLANCLD-----TVKDWvdEIIILDSGSTDNTKEIALSYGA-----KFYENSNWQGFGKQRQLAQ 70
Cdd:COG0463    1 MPLVSVVIPTYNEEEYLEEALEsllaqTYPDF--EIIVVDDGSTDGTAEILRELAAkdpriRVIRLERNRGKGAARNAGL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543996329  71 QYVTSDYVLWLDADERVTLKLQQAILSAVKNDRENTVY--EIPRVSEVFGREIRHSGWYpdYVVRLYRTNYAQYNDSLVH 148
Cdd:COG0463   79 AAARGDYIAFLDADDQLDPEKLEELVAALEEGPADLVYgsRLIREGESDLRRLGSRLFN--LVRLLTNLPDSTSGFRLFR 156

                        170
                 ....*....|..
gi 543996329 149 ----EKVEFPAG 156
Cdd:COG0463  157 revlEELGFDEG 168
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 5-148 1.90e-20

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 85.14  E-value: 1.90e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543996329    5 SVAMIIKNEAQDLANCLDTVKDW---VDEIIILDSGSTDNTKEIALSY-----GAKFYENSNWQGFGKQRQLAQQYVTSD 76
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNQtypNFEIIVVDDGSTDGTVEIAEEYakkdpRVRVIRLPENRGKAGARNAGLRAATGD 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 543996329   77 YVLWLDADERVT-LKLQQAILSAVKNDRENTVYEIPRVSEVFGREIRHSGWYPDYVVRLYRTNYAQYNDSLVH 148
Cdd:pfam00535  81 YIAFLDADDEVPpDWLEKLVEALEEDGADVVVGSRYVIFGETGEYRRASRITLSRLPFFLGLRLLGLNLPFLI 153
PRK13915 PRK13915
putative glucosyl-3-phosphoglycerate synthase; Provisional
 3-84 1.27e-08

putative glucosyl-3-phosphoglycerate synthase; Provisional


Pssm-ID: 237556 [Multi-domain]  Cd Length: 306  Bit Score: 54.54  E-value: 1.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543996329   3 TISVAMIIKNEAQDLANCLDTVK-----DWVDEIIILDSGSTDNTKEIALSYGAKFYensNW----------QGFGKQ-- 65
Cdd:PRK13915  32 TVSVVLPALNEEETVGKVVDSIRpllmePLVDELIVIDSGSTDATAERAAAAGARVV---SReeilpelpprPGKGEAlw 108

                         90
                 ....*....|....*....
gi 543996329  66 RQLAQqyVTSDYVLWLDAD 84
Cdd:PRK13915 109 RSLAA--TTGDIVVFVDAD 125
EPS_HpsE NF038302
hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;
30-84 5.32e-03

hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;


Pssm-ID: 439602 [Multi-domain]  Cd Length: 307  Bit Score: 37.47  E-value: 5.32e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 543996329  30 EIIILDSGSTDNTKEIALSYgakfyeNSNW-------------QGFGKQRQLAQQYVTSDYVLWLDAD 84
Cdd:NF038302  35 EIIVVDNNSTDNTAQVVQEY------QKNWpspyplrycfepqQGAAFARQRAIQEAKGELIGFLDDD 96
 
Name Accession Description Interval E-value
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 3-232 1.45e-94

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 277.25  E-value: 1.45e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543996329   3 TISVAMIIKNEAQDLANCLDTVKDWVDEIIILDSGSTDNTKEIALSYGAKFYENSnWQGFGKQRQLAQQYVTSDYVLWLD 82
Cdd:cd02511    1 TLSVVIITKNEERNIERCLESVKWAVDEIIVVDSGSTDRTVEIAKEYGAKVYQRW-WDGFGAQRNFALELATNDWVLSLD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543996329  83 ADERVTLKLQQAILSAVKNDREnTVYEIPRVSEVFGREIRHSGWYPDYVVRLYRTNYAQYNDSLVHEKVEFPAGTKVEkL 162
Cdd:cd02511   80 ADERLTPELADEILALLATDDY-DGYYVPRRNFFLGRWIRHGGWYPDRQLRLFRRGKARFEDGRVHEQVVVDGGVGIV-L 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 543996329 163 TGDLEHFTYKSIHHYLVKSAGYAKAWADQRQAKGKKATLWQGISHA--LGCFVKMYLLKAGFLDGKQGFLLA 232
Cdd:cd02511  158 KGDILHYGYKSLEEFLEKHNRYSSLEAKDLAAKGKKRSLLKGLLLGrpLLAFLKMYILKRGFLDGRAGFILA 229
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 1-156 4.15e-22

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 90.53  E-value: 4.15e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543996329   1 MPTISVAMIIKNEAQDLANCLD-----TVKDWvdEIIILDSGSTDNTKEIALSYGA-----KFYENSNWQGFGKQRQLAQ 70
Cdd:COG0463    1 MPLVSVVIPTYNEEEYLEEALEsllaqTYPDF--EIIVVDDGSTDGTAEILRELAAkdpriRVIRLERNRGKGAARNAGL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543996329  71 QYVTSDYVLWLDADERVTLKLQQAILSAVKNDRENTVY--EIPRVSEVFGREIRHSGWYpdYVVRLYRTNYAQYNDSLVH 148
Cdd:COG0463   79 AAARGDYIAFLDADDQLDPEKLEELVAALEEGPADLVYgsRLIREGESDLRRLGSRLFN--LVRLLTNLPDSTSGFRLFR 156

                        170
                 ....*....|..
gi 543996329 149 ----EKVEFPAG 156
Cdd:COG0463  157 revlEELGFDEG 168
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 5-148 1.90e-20

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 85.14  E-value: 1.90e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543996329    5 SVAMIIKNEAQDLANCLDTVKDW---VDEIIILDSGSTDNTKEIALSY-----GAKFYENSNWQGFGKQRQLAQQYVTSD 76
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNQtypNFEIIVVDDGSTDGTVEIAEEYakkdpRVRVIRLPENRGKAGARNAGLRAATGD 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 543996329   77 YVLWLDADERVT-LKLQQAILSAVKNDRENTVYEIPRVSEVFGREIRHSGWYPDYVVRLYRTNYAQYNDSLVH 148
Cdd:pfam00535  81 YIAFLDADDEVPpDWLEKLVEALEEDGADVVVGSRYVIFGETGEYRRASRITLSRLPFFLGLRLLGLNLPFLI 153
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 6-140 4.89e-15

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 70.23  E-value: 4.89e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543996329   6 VAMIIKNEAQDLANCLDTV-----KDWvdEIIILDSGSTDNTKEIALSYGAK-----FYENSNWQGFGKQRQLAQQYVTS 75
Cdd:cd00761    1 VIIPAYNEEPYLERCLESLlaqtyPNF--EVIVVDDGSTDGTLEILEEYAKKdprviRVINEENQGLAAARNAGLKAARG 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 543996329  76 DYVLWLDADERVTLKLQQAILSAVKNDRE--------NTVYEIPRVSEVFGREIRHSGWYPDYVVRLYRTNYA 140
Cdd:cd00761   79 EYILFLDADDLLLPDWLERLVAELLADPEadavggpgNLLFRRELLEEIGGFDEALLSGEEDDDFLLRLLRGG 151
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
1-88 1.32e-12

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 64.63  E-value: 1.32e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543996329   1 MPTISVAMIIKNEAQDLANCLDTVK---DWVDEIIILDSGSTDNTKEIALSY---GAKFYENSNWQGFGKQRQLAQQYVT 74
Cdd:COG1216    2 RPKVSVVIPTYNRPELLRRCLESLLaqtYPPFEVIVVDNGSTDGTAELLAALafpRVRVIRNPENLGFAAARNLGLRAAG 81

                         90
                 ....*....|....
gi 543996329  75 SDYVLWLDADERVT 88
Cdd:COG1216   82 GDYLLFLDDDTVVE 95
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 1-87 7.34e-12

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 63.99  E-value: 7.34e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543996329   1 MPTISVAMIIKNEAQDLANCLDTVK-----DWVDEIIILDSGSTDNTKEIALSYGA-----KFYENSNWQGFGKQRQLAQ 70
Cdd:COG1215   28 LPRVSVIIPAYNEEAVIEETLRSLLaqdypKEKLEVIVVDDGSTDETAEIARELAAeyprvRVIERPENGGKAAALNAGL 107

                         90
                 ....*....|....*..
gi 543996329  71 QYVTSDYVLWLDADERV 87
Cdd:COG1215  108 KAARGDIVVFLDADTVL 124
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 12-84 1.40e-09

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 56.04  E-value: 1.40e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543996329  12 NEAQDLANCLDTVKD-----WVDEIIILDSGSTDNTKEIALSYGAKFYENSNW---QGFGKQRQLAQ--QYVTSDYVLWL 81
Cdd:cd04179    7 NEEENIPELVERLLAvleegYDYEIIVVDDGSTDGTAEIARELAARVPRVRVIrlsRNFGKGAAVRAgfKAARGDIVVTM 86


                 ...
gi 543996329  82 DAD 84
Cdd:cd04179   87 DAD 89
PRK13915 PRK13915
putative glucosyl-3-phosphoglycerate synthase; Provisional
 3-84 1.27e-08

putative glucosyl-3-phosphoglycerate synthase; Provisional


Pssm-ID: 237556 [Multi-domain]  Cd Length: 306  Bit Score: 54.54  E-value: 1.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543996329   3 TISVAMIIKNEAQDLANCLDTVK-----DWVDEIIILDSGSTDNTKEIALSYGAKFYensNW----------QGFGKQ-- 65
Cdd:PRK13915  32 TVSVVLPALNEEETVGKVVDSIRpllmePLVDELIVIDSGSTDATAERAAAAGARVV---SReeilpelpprPGKGEAlw 108

                         90
                 ....*....|....*....
gi 543996329  66 RQLAQqyVTSDYVLWLDAD 84
Cdd:PRK13915 109 RSLAA--TTGDIVVFVDAD 125
GT_2_like_a cd02522
GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; ...
 4-104 3.07e-08

GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Glycosyltransferase family 2 (GT-2) subfamily of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133013 [Multi-domain]  Cd Length: 221  Bit Score: 52.57  E-value: 3.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543996329   4 ISVamIIK--NEAQDLANCLDTVKDWVD---EIIILDSGSTDNTKEIALSYGAKFYENSnwQGFGKQRQLAQQYVTSDYV 78
Cdd:cd02522    1 LSI--IIPtlNEAENLPRLLASLRRLNPlplEIIVVDGGSTDGTVAIARSAGVVVISSP--KGRARQMNAGAAAARGDWL 76

                         90       100
                 ....*....|....*....|....*.
gi 543996329  79 LWLDADERVTLKLQQAILSAVKNDRE 104
Cdd:cd02522   77 LFLHADTRLPPDWDAAIIETLRADGA 102
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 3-53 3.92e-07

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 49.54  E-value: 3.92e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 543996329   3 TISVAMIIKNEAQDLANCLDTVKDW-----VDEIIILDSGSTDNTKEIALSYGAKF 53
Cdd:cd02525    1 FVSIIIPVRNEEKYIEELLESLLNQsypkdLIEIIVVDGGSTDGTREIVQEYAAKD 56
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 11-84 5.96e-07

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 48.38  E-value: 5.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543996329  11 KNEAQDLANCLDTVK--DW-VDEIIILDSGSTDNTKEIALSYGAKFYENS----NWQGFGKQRQLAQ--QYVTSDYVLWL 81
Cdd:cd06423    6 YNEEAVIERTIESLLalDYpKLEVIVVDDGSTDDTLEILEELAALYIRRVlvvrDKENGGKAGALNAglRHAKGDIVVVL 85


                 ...
gi 543996329  82 DAD 84
Cdd:cd06423   86 DAD 88
DPG_synthase cd04188
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ...
 12-84 9.89e-07

DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.


Pssm-ID: 133031 [Multi-domain]  Cd Length: 211  Bit Score: 47.95  E-value: 9.89e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543996329  12 NEAQDLANCLDTVKDWVD-------EIIILDSGSTDNTKEIALSYGAKF------YENSNWQGFGKQRQLAQQYVTSDYV 78
Cdd:cd04188    7 NEEKRLPPTLEEAVEYLEerpsfsyEIIVVDDGSKDGTAEVARKLARKNpalirvLTLPKNRGKGGAVRAGMLAARGDYI 86


                 ....*.
gi 543996329  79 LWLDAD 84
Cdd:cd04188   87 LFADAD 92
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 2-102 2.63e-06

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 47.73  E-value: 2.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543996329   2 PTISVAMIIKNEAQDLANCLDTVKD--WVD-EIIILDSGSTDNTKEIALSYGAKF-----YENSNwQGFGKQRQLAQQYV 73
Cdd:PRK10073   6 PKLSIIIPLYNAGKDFRAFMESLIAqtWTAlEIIIVNDGSTDNSVEIAKHYAENYphvrlLHQAN-AGVSVARNTGLAVA 84

                         90       100       110
                 ....*....|....*....|....*....|
gi 543996329  74 TSDYVLWLDADERVTLKLQQAILS-AVKND 102
Cdd:PRK10073  85 TGKYVAFPDADDVVYPTMYETLMTmALEDD 114
GT2_Chondriotin_Pol_N cd06420
N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin ...
 12-84 3.16e-06

N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin polymerase is a two domain, bi-functional protein. The N-terminal domain functions as a GalNAc transferase. The bacterial chondroitin polymerase catalyzes elongation of the chondroitin chain by alternatively transferring the GlcUA and GalNAc moiety from UDP-GlcUA and UDP-GalNAc to the non-reducing ends of the chondroitin chain. The enzyme consists of N-terminal and C-terminal domains in which the two active sites catalyze the addition of GalNAc and GlcUA, respectively. Chondroitin chains range from 40 to over 100 repeating units of the disaccharide. Sulfated chondroitins are involved in the regulation of various biological functions such as central nervous system development, wound repair, infection, growth factor signaling, and morphogenesis, in addition to its conventional structural roles. In Caenorhabditis elegans, chondroitin is an essential factor for the worm to undergo cytokinesis and cell division. Chondroitin is synthesized as proteoglycans, sulfated and secreted to the cell surface or extracellular matrix.


Pssm-ID: 133042 [Multi-domain]  Cd Length: 182  Bit Score: 46.42  E-value: 3.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543996329  12 NEAQDLANCLDTVK---DWVDEIIILDSGSTDNTKEIALSYGAKFYEN--SNWQ---GF--GKQRQLAQQYVTSDYVLWL 81
Cdd:cd06420    7 NRPEALELVLKSVLnqsILPFEVIIADDGSTEETKELIEEFKSQFPIPikHVWQedeGFrkAKIRNKAIAAAKGDYLIFI 86


                 ...
gi 543996329  82 DAD 84
Cdd:cd06420   87 DGD 89
CESA_like_1 cd06439
CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of ...
 2-101 4.32e-06

CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of cellulose synthase (CESA) superfamily. CESA superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members of the superfamily include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins.


Pssm-ID: 133061 [Multi-domain]  Cd Length: 251  Bit Score: 46.42  E-value: 4.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543996329   2 PTISVAMIIKNEAQD----LANC--LDTVKDWVdEIIILDSGSTDNTKEIALSYGAK------FYENSnwqgfGKQRQL- 68
Cdd:cd06439   29 PTVTIIIPAYNEEAVieakLENLlaLDYPRDRL-EIIVVSDGSTDGTAEIAREYADKgvkllrFPERR-----GKAAALn 102

                         90       100       110
                 ....*....|....*....|....*....|....
gi 543996329  69 -AQQYVTSDYVLWLDADervTLKLQQAILSAVKN 101
Cdd:cd06439  103 rALALATGEIVVFTDAN---ALLDPDALRLLVRH 133
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 6-87 1.05e-05

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 44.47  E-value: 1.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543996329   6 VAMIIKNEAQDLANCLDTVK---DWVDEIIILDSGSTDNTKEIALSYGA--KFYENSNWQGFGKQRQLAQQYVTSDYVLW 80
Cdd:cd04186    1 IIIVNYNSLEYLKACLDSLLaqtYPDFEVIVVDNASTDGSVELLRELFPevRLIRNGENLGFGAGNNQGIREAKGDYVLL 80


                 ....*..
gi 543996329  81 LDADERV 87
Cdd:cd04186   81 LNPDTVV 87
Glyco_tranf_2_4 pfam13704
Glycosyl transferase family 2; Members of this family of prokaryotic proteins include putative ...
 11-85 1.77e-04

Glycosyl transferase family 2; Members of this family of prokaryotic proteins include putative glucosyltransferases,


Pssm-ID: 433416 [Multi-domain]  Cd Length: 97  Bit Score: 39.54  E-value: 1.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543996329   11 KNEAQDLANCLDTVKDW-VDEIIILDSGSTDNTKEIALSYGAKF-------YENSNwQGFGKQRQLAQQYVTSDYVLWLD 82
Cdd:pfam13704   1 RNEADILPQWLAHHLALgFDHIYVYDNGSDDGTAEILARLPDVSilrsdlsYKDAR-FQVDWRNALLARYAEADWVLVVD 79


                  ...
gi 543996329   83 ADE 85
Cdd:pfam13704  80 ADE 82
GT_2_WfgS_like cd06433
WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella ...
 5-53 3.43e-04

WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133055 [Multi-domain]  Cd Length: 202  Bit Score: 40.61  E-value: 3.43e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 543996329   5 SVAMIIKNEAQDLANCLDTVK--DWVD-EIIILDSGSTDNTKEIALSYGAKF 53
Cdd:cd06433    1 SIITPTYNQAETLEETIDSVLsqTYPNiEYIVIDGGSTDGTVDIIKKYEDKI 52
GT_2_like_e cd04192
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 11-87 8.75e-04

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133035 [Multi-domain]  Cd Length: 229  Bit Score: 39.58  E-value: 8.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543996329  11 KNEAQDLANCLDTV------KDWVdEIIILDSGSTDNTKEIALSYGAKFYEN----SNWQGF--GKQRQLAQ--QYVTSD 76
Cdd:cd04192    6 RNEAENLPRLLQSLsaldypKEKF-EVILVDDHSTDGTVQILEFAAAKPNFQlkilNNSRVSisGKKNALTTaiKAAKGD 84

                         90
                 ....*....|.
gi 543996329  77 YVLWLDADERV 87
Cdd:cd04192   85 WIVTTDADCVV 95
EpsO_like cd06438
EpsO protein participates in the methanolan synthesis; The Methylobacillus sp EpsO protein is ...
 12-88 1.26e-03

EpsO protein participates in the methanolan synthesis; The Methylobacillus sp EpsO protein is predicted to participate in the methanolan synthesis. Methanolan is an exopolysaccharide (EPS), composed of glucose, mannose and galactose. A 21 genes cluster was predicted to participate in the methanolan synthesis. Gene disruption analysis revealed that EpsO is one of the glycosyltransferase enzymes involved in the synthesis of repeating sugar units onto the lipid carrier.


Pssm-ID: 133060 [Multi-domain]  Cd Length: 183  Bit Score: 38.74  E-value: 1.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543996329  12 NEAQDLANCLDTVK--DWVDEII----ILDSgSTDNTKEIALSYGAKFYENSNWQGFGKQ-------RQLAQQYVTSDYV 78
Cdd:cd06438    7 NEEAVIGNTVRSLKaqDYPRELYrifvVADN-CTDDTAQVARAAGATVLERHDPERRGKGyaldfgfRHLLNLADDPDAV 85

                         90
                 ....*....|
gi 543996329  79 LWLDADERVT 88
Cdd:cd06438   86 VVFDADNLVD 95
GT_2_like_d cd04196
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 23-84 1.45e-03

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133039 [Multi-domain]  Cd Length: 214  Bit Score: 38.77  E-value: 1.45e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 543996329  23 TVKDWvdEIIILDSGSTDNTKEIALSYGAK------FYENSNWQGFGKQRQLAQQYVTSDYVLWLDAD 84
Cdd:cd04196   24 TYKND--ELIISDDGSTDGTVEIIKEYIDKdpfiiiLIRNGKNLGVARNFESLLQAADGDYVFFCDQD 89
DPM1_like cd06442
DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to ...
 12-84 2.52e-03

DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to eukaryotic DPM1, including enzymes from bacteria and archaea; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133062 [Multi-domain]  Cd Length: 224  Bit Score: 38.28  E-value: 2.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 543996329  12 NEAQDLANCLD----TVKDWVDEIIILDSGSTDNTKEIALSYGAKFYE-----NSNWQGFGKQRQLAQQYVTSDYVLWLD 82
Cdd:cd06442    7 NERENIPELIErldaALKGIDYEIIVVDDNSPDGTAEIVRELAKEYPRvrlivRPGKRGLGSAYIEGFKAARGDVIVVMD 86


                 ..
gi 543996329  83 AD 84
Cdd:cd06442   87 AD 88
EPS_HpsE NF038302
hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;
30-84 5.32e-03

hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;


Pssm-ID: 439602 [Multi-domain]  Cd Length: 307  Bit Score: 37.47  E-value: 5.32e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 543996329  30 EIIILDSGSTDNTKEIALSYgakfyeNSNW-------------QGFGKQRQLAQQYVTSDYVLWLDAD 84
Cdd:NF038302  35 EIIVVDNNSTDNTAQVVQEY------QKNWpspyplrycfepqQGAAFARQRAIQEAKGELIGFLDDD 96
DPM1_like_bac cd04187
Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes ...
 30-84 8.78e-03

Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133030 [Multi-domain]  Cd Length: 181  Bit Score: 36.30  E-value: 8.78e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 543996329  30 EIIILDSGSTDNTKEIALSYGA-----KFYENS-NwqgFGKQRQLAQ--QYVTSDYVLWLDAD 84
Cdd:cd04187   31 EIIFVDDGSTDRTLEILRELAArdprvKVIRLSrN---FGQQAALLAglDHARGDAVITMDAD 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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