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Conserved domains on  [gi|530785712|ref|WP_020962478|]
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hypothetical protein [Thermofilum adornatum]

Protein Classification

ATP-binding cassette domain-containing protein( domain architecture ID 1000069)

ATP-binding cassette domain-containing protein may function as an ABC transporter ATP-binding protein is the ATPase, the catalytic subunit of an ATP transporter complex responsible for coupling the energy of ATP hydrolysis to the import of one or more from a variety of substrates

CATH:  3.40.50.300
Gene Ontology:  GO:0005524|GO:0042626|GO:0043190
PubMed:  10529352|25750732|24638992
SCOP:  4003976
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YhaQ super family cl34724
ABC-type uncharacterized transport system, ATPase component [General function prediction only]; ...
 45-191 4.04e-16

ABC-type uncharacterized transport system, ATPase component [General function prediction only];


The actual alignment was detected with superfamily member COG4152:

Pssm-ID: 443322 [Multi-domain]  Cd Length: 298  Bit Score: 74.76  E-value: 4.04e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  45 VGVKGLGSKLLPNLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIaRELKAD---VVLSIHVPEEAEWL 121
Cdd:COG4152  117 LGLGDRANKKVEELSKGNQQKVQLIAALLHDPELLILDEPFSGLDPVNVELLKDVI-RELAAKgttVIFSSHQMELVEEL 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712 122 GEYFIVLRDGRVAWRGTLEDL---ARENIYEVYVRGHVPE-----GLEVVASLGYVALVR-----ASEDVLFELNSRGVI 188
Cdd:COG4152  196 CDRIVIINKGRKVLSGSVDEIrrqFGRNTLRLEADGDAGWlralpGVTVVEEDGDGAELKledgaDAQELLRALLARGPV 275


                 ...
gi 530785712 189 RGF 191
Cdd:COG4152  276 REF 278
 
Name Accession Description Interval E-value
YhaQ COG4152
ABC-type uncharacterized transport system, ATPase component [General function prediction only]; ...
 45-191 4.04e-16

ABC-type uncharacterized transport system, ATPase component [General function prediction only];


Pssm-ID: 443322 [Multi-domain]  Cd Length: 298  Bit Score: 74.76  E-value: 4.04e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  45 VGVKGLGSKLLPNLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIaRELKAD---VVLSIHVPEEAEWL 121
Cdd:COG4152  117 LGLGDRANKKVEELSKGNQQKVQLIAALLHDPELLILDEPFSGLDPVNVELLKDVI-RELAAKgttVIFSSHQMELVEEL 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712 122 GEYFIVLRDGRVAWRGTLEDL---ARENIYEVYVRGHVPE-----GLEVVASLGYVALVR-----ASEDVLFELNSRGVI 188
Cdd:COG4152  196 CDRIVIINKGRKVLSGSVDEIrrqFGRNTLRLEADGDAGWlralpGVTVVEEDGDGAELKledgaDAQELLRALLARGPV 275


                 ...
gi 530785712 189 RGF 191
Cdd:COG4152  276 REF 278
ABC_ThiQ_thiamine_transporter cd03298
ATP-binding cassette domain of the thiamine transport system; Part of the ...
 45-137 5.52e-13

ATP-binding cassette domain of the thiamine transport system; Part of the binding-protein-dependent transport system tbpA-thiPQ for thiamine and TPP. Probably responsible for the translocation of thiamine across the membrane. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213265 [Multi-domain]  Cd Length: 211  Bit Score: 64.82  E-value: 5.52e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  45 VGVKGLGSKLLPNLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPV---NVDAVGSYIARELKADVVLSIHVPEEAEWL 121
Cdd:cd03298  116 VGLAGLEKRLPGELSGGERQRVALARVLVRDKPVLLLDEPFAALDPAlraEMLDLVLDLHAETKMTVLMVTHQPEDAKRL 195

                         90
                 ....*....|....*.
gi 530785712 122 GEYFIVLRDGRVAWRG 137
Cdd:cd03298  196 AQRVVFLDNGRIAAQG 211
PRK15439 PRK15439
autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional
 47-147 1.65e-07

autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional


Pssm-ID: 185336 [Multi-domain]  Cd Length: 510  Bit Score: 50.43  E-value: 1.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  47 VKGLGSKLLPNLSSG-----QKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIaRELKAD----VVLSIHVPEE 117
Cdd:PRK15439 125 LAALGCQLDLDSSAGslevaDRQIVEILRGLMRDSRILILDEPTASLTPAETERLFSRI-RELLAQgvgiVFISHKLPEI 203

                         90       100       110
                 ....*....|....*....|....*....|
gi 530785712 118 AEwLGEYFIVLRDGRVAWRGTLEDLARENI 147
Cdd:PRK15439 204 RQ-LADRISVMRDGTIALSGKTADLSTDDI 232
ECF_ATPase_1 TIGR04520
energy-coupling factor transporter ATPase; Members of this family are ATP-binding cassette ...
 57-142 5.62e-07

energy-coupling factor transporter ATPase; Members of this family are ATP-binding cassette (ABC) proteins by homology, but belong to energy coupling factor (ECF) transport systems. The architecture in general is two ATPase subunits (or a double-length fusion protein), a T component, and a substrate capture (S) component that is highly variable, and may be interchangeable in genomes with only one T component. This model identifies many but not examples of the upstream member of the pair of ECF ATPases in Firmicutes and Mollicutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 275313 [Multi-domain]  Cd Length: 268  Bit Score: 48.58  E-value: 5.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712   57 NLSSGQKQLVQL-----MQglcrvSKIKVLDEAFSHLDPVNVDAVGSYIaRELKAD---VVLSI-HVPEEAEWlGEYFIV 127
Cdd:TIGR04520 136 LLSGGQKQRVAIagvlaMR-----PDIIILDEATSMLDPKGRKEVLETI-RKLNKEegiTVISItHDMEEAVL-ADRVIV 208

                          90
                  ....*....|....*
gi 530785712  128 LRDGRVAWRGTLEDL 142
Cdd:TIGR04520 209 MNKGKIVAEGTPREI 223
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 27-100 2.52e-03

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 38.41  E-value: 2.52e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530785712    27 LHDSDVYHGDCLEFFwdvVGVKGLGSKLLPNLSSGQKQLVQL-----MQGlCRVSKIKVLDEAFSHLDPVNVDAVGSYI 100
Cdd:pfam02463 1050 LEDPDDPFSGGIEIS---ARPPGKGVKNLDLLSGGEKTLVALalifaIQK-YKPAPFYLLDEIDAALDDQNVSRVANLL 1124
 
Name Accession Description Interval E-value
YhaQ COG4152
ABC-type uncharacterized transport system, ATPase component [General function prediction only]; ...
 45-191 4.04e-16

ABC-type uncharacterized transport system, ATPase component [General function prediction only];


Pssm-ID: 443322 [Multi-domain]  Cd Length: 298  Bit Score: 74.76  E-value: 4.04e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  45 VGVKGLGSKLLPNLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIaRELKAD---VVLSIHVPEEAEWL 121
Cdd:COG4152  117 LGLGDRANKKVEELSKGNQQKVQLIAALLHDPELLILDEPFSGLDPVNVELLKDVI-RELAAKgttVIFSSHQMELVEEL 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712 122 GEYFIVLRDGRVAWRGTLEDL---ARENIYEVYVRGHVPE-----GLEVVASLGYVALVR-----ASEDVLFELNSRGVI 188
Cdd:COG4152  196 CDRIVIINKGRKVLSGSVDEIrrqFGRNTLRLEADGDAGWlralpGVTVVEEDGDGAELKledgaDAQELLRALLARGPV 275


                 ...
gi 530785712 189 RGF 191
Cdd:COG4152  276 REF 278
CcmA COG1131
ABC-type multidrug transport system, ATPase component [Defense mechanisms];
43-153 2.76e-14

ABC-type multidrug transport system, ATPase component [Defense mechanisms];


Pssm-ID: 440746 [Multi-domain]  Cd Length: 236  Bit Score: 68.94  E-value: 2.76e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  43 DVVGVKGLGSKLLPNLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIaRELKAD---VVLSIHVPEEAE 119
Cdd:COG1131  117 ELFGLTDAADRKVGTLSGGMKQRLGLALALLHDPELLILDEPTSGLDPEARRELWELL-RELAAEgktVLLSTHYLEEAE 195

                         90       100       110
                 ....*....|....*....|....*....|....
gi 530785712 120 WLGEYFIVLRDGRVAWRGTLEDLARENIYEVYVR 153
Cdd:COG1131  196 RLCDRVAIIDKGRIVADGTPDELKARLLEDVFLE 229
NatA COG4555
ABC-type Na+ transport system, ATPase component NatA [Energy production and conversion, ...
 53-153 5.43e-14

ABC-type Na+ transport system, ATPase component NatA [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 443618 [Multi-domain]  Cd Length: 243  Bit Score: 67.96  E-value: 5.43e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  53 KLLPNLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIaRELKAD---VVLSIHVPEEAEWLGEYFIVLR 129
Cdd:COG4555  128 RRVGELSTGMKKKVALARALVHDPKVLLLDEPTNGLDVMARRLLREIL-RALKKEgktVLFSSHIMQEVEALCDRVVILH 206

                         90       100
                 ....*....|....*....|....*...
gi 530785712 130 DGRVAWRGTLEDLA----RENIYEVYVR 153
Cdd:COG4555  207 KGKVVAQGSLDELReeigEENLEDAFVA 234
ABC_ThiQ_thiamine_transporter cd03298
ATP-binding cassette domain of the thiamine transport system; Part of the ...
 45-137 5.52e-13

ATP-binding cassette domain of the thiamine transport system; Part of the binding-protein-dependent transport system tbpA-thiPQ for thiamine and TPP. Probably responsible for the translocation of thiamine across the membrane. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213265 [Multi-domain]  Cd Length: 211  Bit Score: 64.82  E-value: 5.52e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  45 VGVKGLGSKLLPNLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPV---NVDAVGSYIARELKADVVLSIHVPEEAEWL 121
Cdd:cd03298  116 VGLAGLEKRLPGELSGGERQRVALARVLVRDKPVLLLDEPFAALDPAlraEMLDLVLDLHAETKMTVLMVTHQPEDAKRL 195

                         90
                 ....*....|....*.
gi 530785712 122 GEYFIVLRDGRVAWRG 137
Cdd:cd03298  196 AQRVVFLDNGRIAAQG 211
ABC_ATPase cd00267
ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large ...
 54-132 9.44e-13

ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213179 [Multi-domain]  Cd Length: 157  Bit Score: 63.03  E-value: 9.44e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  54 LLPNLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIaRELKAD---VVLSIHVPEEAEWLGEYFIVLRD 130
Cdd:cd00267   77 YVPQLSGGQRQRVALARALLLNPDLLLLDEPTSGLDPASRERLLELL-RELAEEgrtVIIVTHDPELAELAADRVIVLKD 155


                 ..
gi 530785712 131 GR 132
Cdd:cd00267  156 GK 157
ABC_DR_subfamily_A cd03230
ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily ...
 58-133 3.28e-12

ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; This family of ATP-binding proteins belongs to a multi-subunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding protein and one or two integral membrane proteins. Eukaryotic systems of the ABCA subfamily display ABC domains that are quite similar to this family. The ATP-binding domain shows the highest similarity between all members of the ABC transporter family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213197 [Multi-domain]  Cd Length: 173  Bit Score: 62.03  E-value: 3.28e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530785712  58 LSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIaRELKAD---VVLSIHVPEEAEWLGEYFIVLRDGRV 133
Cdd:cd03230   96 LSGGMKQRLALAQALLHDPELLILDEPTSGLDPESRREFWELL-RELKKEgktILLSSHILEEAERLCDRVAILNNGRI 173
ABC_Iron-Siderophores_B12_Hemin cd03214
ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related ...
 43-133 4.26e-11

ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC transporter mediating vitamin B12 uptake. The two ATP-binding cassettes (BtuD) are in close contact with each other, as are the two membrane-spanning subunits (BtuC); this arrangement is distinct from that observed for the E. coli lipid flippase MsbA. The BtuC subunits provide 20 transmembrane helices grouped around a translocation pathway that is closed to the cytoplasm by a gate region, whereas the dimer arrangement of the BtuD subunits resembles the ATP-bound form of the Rad50 DNA repair enzyme. A prominent cytoplasmic loop of BtuC forms the contact region with the ATP-binding cassette and represent a conserved motif among the ABC transporters.


Pssm-ID: 213181 [Multi-domain]  Cd Length: 180  Bit Score: 58.99  E-value: 4.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  43 DVVGVKGLGSKLLPNLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYI---ARELKADVVLSIHVPEEAE 119
Cdd:cd03214   83 ELLGLAHLADRPFNELSGGERQRVLLARALAQEPPILLLDEPTSHLDIAHQIELLELLrrlARERGKTVVMVLHDLNLAA 162

                         90
                 ....*....|....
gi 530785712 120 WLGEYFIVLRDGRV 133
Cdd:cd03214  163 RYADRVILLKDGRI 176
ThiQ COG3840
ABC-type thiamine transport system, ATPase component ThiQ [Coenzyme transport and metabolism];
45-146 4.96e-11

ABC-type thiamine transport system, ATPase component ThiQ [Coenzyme transport and metabolism];


Pssm-ID: 443051 [Multi-domain]  Cd Length: 232  Bit Score: 59.77  E-value: 4.96e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  45 VGVKGLGSKLLPNLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVN-------VDAvgsyIARELKADVVLSIHVPEE 117
Cdd:COG3840  117 VGLAGLLDRLPGQLSGGQRQRVALARCLVRKRPILLLDEPFSALDPALrqemldlVDE----LCRERGLTVLMVTHDPED 192

                         90       100
                 ....*....|....*....|....*....
gi 530785712 118 AEWLGEYFIVLRDGRVAWRGTLEDLAREN 146
Cdd:COG3840  193 AARIADRVLLVADGRIAADGPTAALLDGE 221
ABC_putative_ATPase cd03269
ATP-binding cassette domain of an uncharacterized transporter; This subgroup is related to the ...
 45-133 8.96e-11

ATP-binding cassette domain of an uncharacterized transporter; This subgroup is related to the subfamily A transporters involved in drug resistance, nodulation, lipid transport, and bacteriocin and lantibiotic immunity. In eubacteria and archaea, the typical organization consists of one ABC and one or two integral membranes. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region in addition to the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213236 [Multi-domain]  Cd Length: 210  Bit Score: 58.83  E-value: 8.96e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  45 VGVKGLGSKLLPNLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIaRELKAD---VVLSIHVPEEAEWL 121
Cdd:cd03269  116 LELSEYANKRVEELSKGNQQKVQFIAAVIHDPELLILDEPFSGLDPVNVELLKDVI-RELARAgktVILSTHQMELVEEL 194

                         90
                 ....*....|..
gi 530785712 122 GEYFIVLRDGRV 133
Cdd:cd03269  195 CDRVLLLNKGRA 206
FepC COG1120
ABC-type cobalamin/Fe3+-siderophores transport system, ATPase component [Inorganic ion ...
 43-156 9.64e-11

ABC-type cobalamin/Fe3+-siderophores transport system, ATPase component [Inorganic ion transport and metabolism, Coenzyme transport and metabolism];


Pssm-ID: 440737 [Multi-domain]  Cd Length: 254  Bit Score: 59.29  E-value: 9.64e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  43 DVVGVKGLGSKLLPNLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIaRELKAD----VVLSIHVPEEA 118
Cdd:COG1120  123 ERTGLEHLADRPVDELSGGERQRVLIARALAQEPPLLLLDEPTSHLDLAHQLEVLELL-RRLARErgrtVVMVLHDLNLA 201

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 530785712 119 EWLGEYFIVLRDGRVAWRGTLED-LARENIYEVY-VRGHV 156
Cdd:COG1120  202 ARYADRLVLLKDGRIVAQGPPEEvLTPELLEEVYgVEARV 241
ABC_PhnC_transporter cd03256
ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; ...
 1-151 7.19e-10

ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all kingdoms of wildlife, but only prokaryotic microorganisms are able to cleave this bond. Certain bacteria such as E. coli can use alkylphosphonates as a phosphorus source. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213223 [Multi-domain]  Cd Length: 241  Bit Score: 56.81  E-value: 7.19e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712   1 MSFLGVLLGFLPTIIYYVAYYpglkslhdsdvyhgdCLEffwdVVGVKGLGSKLLPNLSSGQKQLVQLMQGLCRVSKIKV 80
Cdd:cd03256  107 RSTWRSLFGLFPKEEKQRALA---------------ALE----RVGLLDKAYQRADQLSGGQQQRVAIARALMQQPKLIL 167

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530785712  81 LDEAFSHLDPVNVDAVGSY---IARELKADVVLSIHVPEEAEWLGEYFIVLRDGRVAWRGTLEDLARENIYEVY 151
Cdd:cd03256  168 ADEPVASLDPASSRQVMDLlkrINREEGITVIVSLHQVDLAREYADRIVGLKDGRIVFDGPPAELTDEVLDEIY 241
EcfA2 COG1122
Energy-coupling factor transporter ATP-binding protein EcfA2 [Inorganic ion transport and ...
 43-142 7.71e-09

Energy-coupling factor transporter ATP-binding protein EcfA2 [Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440739 [Multi-domain]  Cd Length: 230  Bit Score: 53.49  E-value: 7.71e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  43 DVVGVKGLGSKLLPNLSSGQKQLVQL-----MQglcrvSKIKVLDEAFSHLDPVNVDAVGSYIaRELKAD---VVLSIHV 114
Cdd:COG1122  120 ELVGLEHLADRPPHELSGGQKQRVAIagvlaME-----PEVLVLDEPTAGLDPRGRRELLELL-KRLNKEgktVIIVTHD 193

                         90       100
                 ....*....|....*....|....*...
gi 530785712 115 PEEAEWLGEYFIVLRDGRVAWRGTLEDL 142
Cdd:COG1122  194 LDLVAELADRVIVLDDGRIVADGTPREV 221
ABC_Carb_Monos_I cd03216
First domain of the ATP-binding cassette component of monosaccharide transport system; This ...
 58-134 2.99e-08

First domain of the ATP-binding cassette component of monosaccharide transport system; This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (such as xylose, arabinose, and ribose), that cannot be broken down to simple sugars by hydrolysis. Pentoses include xylose, arabinose, and ribose. Important hexoses include glucose, galactose, and fructose. In members of the Carb_monos family, the single hydrophobic gene product forms a homodimer while the ABC protein represents a fusion of two nucleotide-binding domains. However, it is assumed that two copies of the ABC domains are present in the assembled transporter.


Pssm-ID: 213183 [Multi-domain]  Cd Length: 163  Bit Score: 50.89  E-value: 2.99e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  58 LSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIaRELKAD---VVLSIHVPEEAEWLGEYFIVLRDGRVA 134
Cdd:cd03216   83 LSVGERQMVEIARALARNARLLILDEPTAALTPAEVERLFKVI-RRLRAQgvaVIFISHRLDEVFEIADRVTVLRDGRVV 161
ABC_cobalt_CbiO_domain1 cd03225
First domain of the ATP-binding cassette component of cobalt transport system; Domain I of the ...
 42-132 3.37e-08

First domain of the ATP-binding cassette component of cobalt transport system; Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC transport system of the CbiMNQO family is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most of cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems.


Pssm-ID: 213192 [Multi-domain]  Cd Length: 211  Bit Score: 51.70  E-value: 3.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  42 WDVVGVKGLGSKLLPNLSSGQKQLVQL-----MQglcrvSKIKVLDEAFSHLDPVNVDAVGSYIaRELKAD---VVLSIH 113
Cdd:cd03225  119 LELVGLEGLRDRSPFTLSGGQKQRVAIagvlaMD-----PDILLLDEPTAGLDPAGRRELLELL-KKLKAEgktIIIVTH 192

                         90
                 ....*....|....*....
gi 530785712 114 VPEEAEWLGEYFIVLRDGR 132
Cdd:cd03225  193 DLDLLLELADRVIVLEDGK 211
ABC_ModC_molybdenum_transporter cd03297
ATP-binding cassette domain of the molybdenum transport system; ModC is an ABC-type ...
 43-137 3.44e-08

ATP-binding cassette domain of the molybdenum transport system; ModC is an ABC-type transporter and the ATPase component of a molybdate transport system that also includes the periplasmic binding protein ModA and the membrane protein ModB. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213264 [Multi-domain]  Cd Length: 214  Bit Score: 51.53  E-value: 3.44e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  43 DVVGVKGLGSKLLPNLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSY---IARELKADVVLSIHVPEEAE 119
Cdd:cd03297  117 DLLGLDHLLNRYPAQLSGGEKQRVALARALAAQPELLLLDEPFSALDRALRLQLLPElkqIKKNLNIPVIFVTHDLSEAE 196

                         90
                 ....*....|....*...
gi 530785712 120 WLGEYFIVLRDGRVAWRG 137
Cdd:cd03297  197 YLADRIVVMEDGRLQYIG 214
ABC_Pro_Gly_Betaine cd03294
ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; This ...
 45-142 4.29e-08

ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporters is the obligatory coupling of ATP hydrolysis to substrate translocation. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213261 [Multi-domain]  Cd Length: 269  Bit Score: 51.88  E-value: 4.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  45 VGVKGLGSKLLPNLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVnvdavgsyIARELKaDVVLSI------------ 112
Cdd:cd03294  148 VGLEGWEHKYPDELSGGMQQRVGLARALAVDPDILLMDEAFSALDPL--------IRREMQ-DELLRLqaelqktivfit 218

                         90       100       110
                 ....*....|....*....|....*....|
gi 530785712 113 HVPEEAEWLGEYFIVLRDGRVAWRGTLEDL 142
Cdd:cd03294  219 HDLDEALRLGDRIAIMKDGRLVQVGTPEEI 248
ABC_Carb_Solutes_like cd03259
ATP-binding cassette domain of the carbohydrate and solute transporters-like; This family is ...
 58-137 5.05e-08

ATP-binding cassette domain of the carbohydrate and solute transporters-like; This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213226 [Multi-domain]  Cd Length: 213  Bit Score: 50.98  E-value: 5.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  58 LSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIA---RELKADVVLSIHVPEEAEWLGEYFIVLRDGRVA 134
Cdd:cd03259  131 LSGGQQQRVALARALAREPSLLLLDEPLSALDAKLREELREELKelqRELGITTIYVTHDQEEALALADRIAVMNEGRIV 210


                 ...
gi 530785712 135 WRG 137
Cdd:cd03259  211 QVG 213
ABC_NatA_sodium_exporter cd03266
ATP-binding cassette domain of the Na+ transporter; NatA is the ATPase component of a ...
 18-137 6.33e-08

ATP-binding cassette domain of the Na+ transporter; NatA is the ATPase component of a bacterial ABC-type Na+ transport system called NatAB, which catalyzes ATP-dependent electrogenic Na+ extrusion without mechanically coupled proton or K+ uptake. NatB possess six putative membrane spanning regions at its C-terminus. In B. subtilis, NatAB is inducible by agents such as ethanol and protonophores, which lower the proton-motive force across the membrane. The closest sequence similarity to NatA is exhibited by DrrA of the two-component daunorubicin- and doxorubicin-efflux system. Hence, the functional NatAB is presumably assembled with two copies of a single ATP-binding protein and a single integral membrane protein.


Pssm-ID: 213233 [Multi-domain]  Cd Length: 218  Bit Score: 50.83  E-value: 6.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  18 VAYYPGLKSLhDSDVYHGDcLEFFWDVVGVKGLGSKLLPNLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVG 97
Cdd:cd03266   99 LEYFAGLYGL-KGDELTAR-LEELADRLGMEELLDRRVGGFSTGMRQKVAIARALVHDPPVLLLDEPTTGLDVMATRALR 176

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 530785712  98 SYIaRELKAD---VVLSIHVPEEAEWLGEYFIVLRDGRVAWRG 137
Cdd:cd03266  177 EFI-RQLRALgkcILFSTHIMQEVERLCDRVVVLHRGRVVYEG 218
ABC_Class3 cd03229
ATP-binding cassette domain of the binding protein-dependent transport systems; This class is ...
 58-132 7.50e-08

ATP-binding cassette domain of the binding protein-dependent transport systems; This class is comprised of all BPD (Binding Protein Dependent) systems that are largely represented in archaea and eubacteria and are primarily involved in scavenging solutes from the environment. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213196 [Multi-domain]  Cd Length: 178  Bit Score: 50.26  E-value: 7.50e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530785712  58 LSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIaRELKAD----VVLSIHVPEEAEWLGEYFIVLRDGR 132
Cdd:cd03229  101 LSGGQQQRVALARALAMDPDVLLLDEPTSALDPITRREVRALL-KSLQAQlgitVVLVTHDLDEAARLADRVVVLRDGK 178
PRK15439 PRK15439
autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional
 47-147 1.65e-07

autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional


Pssm-ID: 185336 [Multi-domain]  Cd Length: 510  Bit Score: 50.43  E-value: 1.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  47 VKGLGSKLLPNLSSG-----QKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIaRELKAD----VVLSIHVPEE 117
Cdd:PRK15439 125 LAALGCQLDLDSSAGslevaDRQIVEILRGLMRDSRILILDEPTASLTPAETERLFSRI-RELLAQgvgiVFISHKLPEI 203

                         90       100       110
                 ....*....|....*....|....*....|
gi 530785712 118 AEwLGEYFIVLRDGRVAWRGTLEDLARENI 147
Cdd:PRK15439 204 RQ-LADRISVMRDGTIALSGKTADLSTDDI 232
CcmA COG4133
ABC-type transport system involved in cytochrome c biogenesis, ATPase component ...
 43-124 3.11e-07

ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443308 [Multi-domain]  Cd Length: 206  Bit Score: 48.63  E-value: 3.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  43 DVVGVKGLGSKLLPNLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIARELKAD--VVLSIHVPEEAE- 119
Cdd:COG4133  117 EAVGLAGLADLPVRQLSAGQKRRVALARLLLSPAPLWLLDEPFTALDAAGVALLAELIAAHLARGgaVLLTTHQPLELAa 196


                 ....*....
gi 530785712 120 ----WLGEY 124
Cdd:COG4133  197 arvlDLGDF 205
ABCC_MRP_domain2 cd03244
ATP-binding cassette domain 2 of multidrug resistance-associated protein; The ABC subfamily C ...
 57-112 4.90e-07

ATP-binding cassette domain 2 of multidrug resistance-associated protein; The ABC subfamily C is also known as MRP (multidrug resistance-associated protein). Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional membrane-spanning domains is not clear. The MRP was found in the multidrug-resistance lung cancer cell in which p-glycoprotein was not overexpressed. MRP exports glutathione by drug stimulation, as well as, certain substrates in conjugated forms with anions, such as glutathione, glucuronate, and sulfate.


Pssm-ID: 213211 [Multi-domain]  Cd Length: 221  Bit Score: 48.26  E-value: 4.90e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 530785712  57 NLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIARELKADVVLSI 112
Cdd:cd03244  139 NLSVGQRQLLCLARALLRKSKILVLDEATASVDPETDALIQKTIREAFKDCTVLTI 194
ECF_ATPase_1 TIGR04520
energy-coupling factor transporter ATPase; Members of this family are ATP-binding cassette ...
 57-142 5.62e-07

energy-coupling factor transporter ATPase; Members of this family are ATP-binding cassette (ABC) proteins by homology, but belong to energy coupling factor (ECF) transport systems. The architecture in general is two ATPase subunits (or a double-length fusion protein), a T component, and a substrate capture (S) component that is highly variable, and may be interchangeable in genomes with only one T component. This model identifies many but not examples of the upstream member of the pair of ECF ATPases in Firmicutes and Mollicutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 275313 [Multi-domain]  Cd Length: 268  Bit Score: 48.58  E-value: 5.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712   57 NLSSGQKQLVQL-----MQglcrvSKIKVLDEAFSHLDPVNVDAVGSYIaRELKAD---VVLSI-HVPEEAEWlGEYFIV 127
Cdd:TIGR04520 136 LLSGGQKQRVAIagvlaMR-----PDIIILDEATSMLDPKGRKEVLETI-RKLNKEegiTVISItHDMEEAVL-ADRVIV 208

                          90
                  ....*....|....*
gi 530785712  128 LRDGRVAWRGTLEDL 142
Cdd:TIGR04520 209 MNKGKIVAEGTPREI 223
SunT COG2274
ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase ...
 57-148 7.87e-07

ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms];


Pssm-ID: 441875 [Multi-domain]  Cd Length: 711  Bit Score: 48.68  E-value: 7.87e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  57 NLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIARELKADVVLSI-HVPE---EAEWLgeyfIVLRDGR 132
Cdd:COG2274  611 NLSGGQRQRLAIARALLRNPRILILDEATSALDAETEAIILENLRRLLKGRTVIIIaHRLStirLADRI----IVLDKGR 686

                         90
                 ....*....|....*..
gi 530785712 133 VAWRGTLEDL-ARENIY 148
Cdd:COG2274  687 IVEDGTHEELlARKGLY 703
GsiA COG1123
ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain ...
 45-201 8.27e-07

ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440740 [Multi-domain]  Cd Length: 514  Bit Score: 48.36  E-value: 8.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  45 VGVKGLGSKLLPNLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIA---RELKADVVLSIHVPEEAEWL 121
Cdd:COG1123  130 VGLERRLDRYPHQLSGGQRQRVAIAMALALDPDLLIADEPTTALDVTTQAEILDLLRelqRERGTTVLLITHDLGVVAEI 209

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712 122 GEYFIVLRDGRVAWRGTLEDLAREniyevyvrghvPEGLEVVASLG----YVALVRASEDVLFELnsRGVIRGFRRAGVR 197
Cdd:COG1123  210 ADRVVVMDDGRIVEDGPPEEILAA-----------PQALAAVPRLGaargRAAPAAAAAEPLLEV--RNLSKRYPVRGKG 276


                 ....
gi 530785712 198 VYYA 201
Cdd:COG1123  277 GVRA 280
cbiO PRK13647
cobalt transporter ATP-binding subunit; Provisional
 43-149 9.15e-07

cobalt transporter ATP-binding subunit; Provisional


Pssm-ID: 237457 [Multi-domain]  Cd Length: 274  Bit Score: 47.81  E-value: 9.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  43 DVVGVKGLGSKLLPNLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIARELKA--DVVLSIH-VPEEAE 119
Cdd:PRK13647 124 KAVRMWDFRDKPPYHLSYGQKKRVAIAGVLAMDPDVIVLDEPMAYLDPRGQETLMEILDRLHNQgkTVIVATHdVDLAAE 203

                         90       100       110
                 ....*....|....*....|....*....|
gi 530785712 120 WlGEYFIVLRDGRVAWRGTLEDLARENIYE 149
Cdd:PRK13647 204 W-ADQVIVLKEGRVLAEGDKSLLTDEDIVE 232
thiQ PRK10771
thiamine ABC transporter ATP-binding protein ThiQ;
45-158 1.14e-06

thiamine ABC transporter ATP-binding protein ThiQ;


Pssm-ID: 182716 [Multi-domain]  Cd Length: 232  Bit Score: 47.27  E-value: 1.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  45 VGVKGLGSKLLPNLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDP-------VNVDAVgsyiARELKADVVLSIHVPEE 117
Cdd:PRK10771 117 MGIEDLLARLPGQLSGGQRQRVALARCLVREQPILLLDEPFSALDPalrqemlTLVSQV----CQERQLTLLMVSHSLED 192

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 530785712 118 AEWLGEYFIVLRDGRVAWRGTLEDLareniyevyVRGHVPE 158
Cdd:PRK10771 193 AARIAPRSLVVADGRIAWDGPTDEL---------LSGKASA 224
ZnuC COG1121
ABC-type Mn2+/Zn2+ transport system, ATPase component [Inorganic ion transport and metabolism]; ...
 43-151 2.09e-06

ABC-type Mn2+/Zn2+ transport system, ATPase component [Inorganic ion transport and metabolism];


Pssm-ID: 440738 [Multi-domain]  Cd Length: 245  Bit Score: 46.62  E-value: 2.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  43 DVVGVKGLGSKLLPNLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIaRELKAD---VVLSIHVPEEAE 119
Cdd:COG1121  125 ERVGLEDLADRPIGELSGGQQQRVLLARALAQDPDLLLLDEPFAGVDAATEEALYELL-RELRREgktILVVTHDLGAVR 203

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 530785712 120 wlgEYF---IVLRDGRVAWRGTLEDLARENIYEVY 151
Cdd:COG1121  204 ---EYFdrvLLLNRGLVAHGPPEEVLTPENLSRAY 235
ABCC_Glucan_exporter_like cd03254
ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Glucan ...
 57-142 2.33e-06

ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virulence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and lipid export. The MRP-like family, similar to all ABC proteins, have a common four-domain core structure constituted by two membrane-spanning domains each composed of six transmembrane (TM) helices and two nucleotide-binding domains (NBD). ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213221 [Multi-domain]  Cd Length: 229  Bit Score: 46.45  E-value: 2.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  57 NLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIARELKADVVLSI-HVP---EEAEWLgeyfIVLRDGR 132
Cdd:cd03254  139 NLSQGERQLLAIARAMLRDPKILILDEATSNIDTETEKLIQEALEKLMKGRTSIIIaHRLstiKNADKI----LVLDDGK 214

                         90
                 ....*....|
gi 530785712 133 VAWRGTLEDL 142
Cdd:cd03254  215 IIEEGTHDEL 224
ABCC_Protease_Secretion cd03246
ATP-binding cassette domain of PrtD, subfamily C; This family represents the ABC component of ...
 58-133 3.52e-06

ATP-binding cassette domain of PrtD, subfamily C; This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export degradative enzymes by using a type I protein secretion system and lack an N-terminal signal peptide, but contain a C-terminal secretion signal. The Type I secretion apparatus is made up of three components, an ABC transporter, a membrane fusion protein (MFP), and an outer membrane protein (OMP). For the HlyA transporter complex, HlyB (ABC transporter) and HlyD (MFP) reside in the inner membrane of E. coli. The OMP component is TolC, which is thought to interact with the MFP to form a continuous channel across the periplasm from the cytoplasm to the exterior. HlyB belongs to the family of ABC transporters, which are ubiquitous, ATP-dependent transmembrane pumps or channels. The spectrum of transport substrates ranges from inorganic ions, nutrients such as amino acids, sugars, or peptides, hydrophobic drugs, to large polypeptides, such as HlyA.


Pssm-ID: 213213 [Multi-domain]  Cd Length: 173  Bit Score: 45.29  E-value: 3.52e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530785712  58 LSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIA--RELKADVVLSIHVPEEAEwLGEYFIVLRDGRV 133
Cdd:cd03246   97 LSGGQRQRLGLARALYGNPRILVLDEPNSHLDVEGERALNQAIAalKAAGATRIVIAHRPETLA-SADRILVLEDGRV 173
PRK14247 PRK14247
phosphate ABC transporter ATP-binding protein; Provisional
 58-156 3.96e-06

phosphate ABC transporter ATP-binding protein; Provisional


Pssm-ID: 172735 [Multi-domain]  Cd Length: 250  Bit Score: 46.06  E-value: 3.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  58 LSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIArELKAD--VVLSIHVPEEAEWLGEYFIVLRDGRVAW 135
Cdd:PRK14247 147 LSGGQQQRLCIARALAFQPEVLLADEPTANLDPENTAKIESLFL-ELKKDmtIVLVTHFPQQAARISDYVAFLYKGQIVE 225

                         90       100
                 ....*....|....*....|....
gi 530785712 136 RGTLEDL---ARENIYEVYVRGHV 156
Cdd:PRK14247 226 WGPTREVftnPRHELTEKYVTGRL 249
ABC_OpuCA_Osmoprotection cd03295
ATP-binding cassette domain of the osmoprotectant transporter; OpuCA is a the ATP binding ...
 58-144 4.37e-06

ATP-binding cassette domain of the osmoprotectant transporter; OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition, to the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213262 [Multi-domain]  Cd Length: 242  Bit Score: 45.75  E-value: 4.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  58 LSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIAR---ELKADVVLSIHVPEEAEWLGEYFIVLRDGRVA 134
Cdd:cd03295  136 LSGGQQQRVGVARALAADPPLLLMDEPFGALDPITRDQLQEEFKRlqqELGKTIVFVTHDIDEAFRLADRIAIMKNGEIV 215

                         90
                 ....*....|
gi 530785712 135 WRGTLEDLAR 144
Cdd:cd03295  216 QVGTPDEILR 225
ABC_Org_Solvent_Resistant cd03261
ATP-binding cassette transport system involved in resistance to organic solvents; ABC ...
 43-142 4.65e-06

ATP-binding cassette transport system involved in resistance to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213228 [Multi-domain]  Cd Length: 235  Bit Score: 45.57  E-value: 4.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  43 DVVGVKGLGSKLLPNLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYI---ARELKADVVLSIHVPEEAE 119
Cdd:cd03261  122 EAVGLRGAEDLYPAELSGGMKKRVALARALALDPELLLYDEPTAGLDPIASGVIDDLIrslKKELGLTSIMVTHDLDTAF 201

                         90       100
                 ....*....|....*....|...
gi 530785712 120 WLGEYFIVLRDGRVAWRGTLEDL 142
Cdd:cd03261  202 AIADRIAVLYDGKIVAEGTPEEL 224
cbiO PRK13640
energy-coupling factor transporter ATPase;
57-142 7.81e-06

energy-coupling factor transporter ATPase;


Pssm-ID: 184200 [Multi-domain]  Cd Length: 282  Bit Score: 45.18  E-value: 7.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  57 NLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIaRELKAD---VVLSI-HVPEEAEwLGEYFIVLRDGR 132
Cdd:PRK13640 143 NLSGGQKQRVAIAGILAVEPKIIILDESTSMLDPAGKEQILKLI-RKLKKKnnlTVISItHDIDEAN-MADQVLVLDDGK 220

                         90
                 ....*....|
gi 530785712 133 VAWRGTLEDL 142
Cdd:PRK13640 221 LLAQGSPVEI 230
ABCC_MRP_Like cd03228
ATP-binding cassette domain of multidrug resistance protein-like transporters; The MRP ...
 58-132 8.92e-06

ATP-binding cassette domain of multidrug resistance protein-like transporters; The MRP (Multidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a diverse functional spectrum that includes ion transport, cell surface receptor, and toxin secretion activities. The MRP-like family, similar to all ABC proteins, have a common four-domain core structure constituted by two membrane-spanning domains, each composed of six transmembrane (TM) helices, and two nucleotide-binding domains (NBD). ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213195 [Multi-domain]  Cd Length: 171  Bit Score: 44.30  E-value: 8.92e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530785712  58 LSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIARELKADVVLSI-HVPEEAEwLGEYFIVLRDGR 132
Cdd:cd03228   97 LSGGQRQRIAIARALLRDPPILILDEATSALDPETEALILEALRALAKGKTVIVIaHRLSTIR-DADRIIVLDDGR 171
cbiO PRK13635
energy-coupling factor ABC transporter ATP-binding protein;
58-140 1.43e-05

energy-coupling factor ABC transporter ATP-binding protein;


Pssm-ID: 184195 [Multi-domain]  Cd Length: 279  Bit Score: 44.62  E-value: 1.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  58 LSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIaRELKAD---VVLSI-HVPEEAEwLGEYFIVLRDGRV 133
Cdd:PRK13635 141 LSGGQKQRVAIAGVLALQPDIIILDEATSMLDPRGRREVLETV-RQLKEQkgiTVLSItHDLDEAA-QADRVIVMNKGEI 218


                 ....*..
gi 530785712 134 AWRGTLE 140
Cdd:PRK13635 219 LEEGTPE 225
CydC COG4987
ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease ...
 57-146 1.70e-05

ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444011 [Multi-domain]  Cd Length: 569  Bit Score: 44.76  E-value: 1.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  57 NLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIARELKADVVLSI-HVPEEAEWLGEyFIVLRDGRVAW 135
Cdd:COG4987  471 RLSGGERRRLALARALLRDAPILLLDEPTEGLDAATEQALLADLLEALAGRTVLLItHRLAGLERMDR-ILVLEDGRIVE 549

                         90
                 ....*....|.
gi 530785712 136 RGTLEDLAREN 146
Cdd:COG4987  550 QGTHEELLAQN 560
CydD COG4988
ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease ...
 57-146 2.32e-05

ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444012 [Multi-domain]  Cd Length: 563  Bit Score: 44.36  E-value: 2.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  57 NLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIaRELKAD--VVLSIHVPEEAEWlGEYFIVLRDGRVA 134
Cdd:COG4988  473 GLSGGQAQRLALARALLRDAPLLLLDEPTAHLDAETEAEILQAL-RRLAKGrtVILITHRLALLAQ-ADRILVLDDGRIV 550

                         90
                 ....*....|..
gi 530785712 135 WRGTLEDLAREN 146
Cdd:COG4988  551 EQGTHEELLAKN 562
ABC_drug_resistance_like cd03264
ABC-type multidrug transport system, ATPase component; The biological function of this family ...
 7-137 3.16e-05

ABC-type multidrug transport system, ATPase component; The biological function of this family is not well characterized, but display ABC domains similar to members of ABCA subfamily. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213231 [Multi-domain]  Cd Length: 211  Bit Score: 42.95  E-value: 3.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712   7 LLGFLP---------TIIYYVAYYPGLKSLHDSDVYHGDC--LEffwdVVGVKGLGSKLLPNLSSGQKQLVQLMQGLCRV 75
Cdd:cd03264   73 RIGYLPqefgvypnfTVREFLDYIAWLKGIPSKEVKARVDevLE----LVNLGDRAKKKIGSLSGGMRRRVGIAQALVGD 148

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530785712  76 SKIKVLDEAFSHLDPVNVDAVGSYIArELKAD--VVLSIHVPEEAEWLGEYFIVLRDGRVAWRG 137
Cdd:cd03264  149 PSILIVDEPTAGLDPEERIRFRNLLS-ELGEDriVILSTHIVEDVESLCNQVAVLNKGKLVFEG 211
MRP_assoc_pro TIGR00957
multi drug resistance-associated protein (MRP); This model describes multi drug ...
 57-112 3.26e-05

multi drug resistance-associated protein (MRP); This model describes multi drug resistance-associated protein (MRP) in eukaryotes. The multidrug resistance-associated protein is an integral membrane protein that causes multidrug resistance when overexpressed in mammalian cells. It belongs to ABC transporter superfamily. The protein topology and function was experimentally demonstrated by epitope tagging and immunofluorescence. Insertion of tags in the critical regions associated with drug efflux, abrogated its function. The C-terminal domain seem to highly conserved. [Transport and binding proteins, Other]


Pssm-ID: 188098 [Multi-domain]  Cd Length: 1522  Bit Score: 44.17  E-value: 3.26e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 530785712    57 NLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIARELKADVVLSI 112
Cdd:TIGR00957 1421 NLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTI 1476
ABC_subfamily_A cd03263
ATP-binding cassette domain of the lipid transporters, subfamily A; The ABCA subfamily ...
 6-133 3.39e-05

ATP-binding cassette domain of the lipid transporters, subfamily A; The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency, degenerative retinopathies, and congenital keratinization disorders. The ABCA1 protein is involved in disorders of cholesterol transport and high-density lipoprotein (HDL) biosynthesis. The ABCA4 (ABCR) protein transports vitamin A derivatives in the outer segments of photoreceptor cells, and therefore, performs a crucial step in the visual cycle. The ABCA genes are not present in yeast. However, evolutionary studies of ABCA genes indicate that they arose as transporters that subsequently duplicated and that certain sets of ABCA genes were lost in different eukaryotic lineages.


Pssm-ID: 213230 [Multi-domain]  Cd Length: 220  Bit Score: 42.88  E-value: 3.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712   6 VLLGFLpTIIYYVAYYPGLKSLHDSDVYHgdCLEFFWDVVGVKGLGSKLLPNLSSGQKQLVQLMQGLCRVSKIKVLDEAF 85
Cdd:cd03263   85 ALFDEL-TVREHLRFYARLKGLPKSEIKE--EVELLLRVLGLTDKANKRARTLSGGMKRKLSLAIALIGGPSVLLLDEPT 161

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 530785712  86 SHLDPVNVDAVGSYIARELKA-DVVLSIHVPEEAEWLGEYFIVLRDGRV 133
Cdd:cd03263  162 SGLDPASRRAIWDLILEVRKGrSIILTTHSMDEAEALCDRIAIMSDGKL 210
ABCC_NFT1 cd03369
ATP-binding cassette domain 2 of NFT1, subfamily C; Domain 2 of NFT1 (New full-length MRP-type ...
 57-112 6.54e-05

ATP-binding cassette domain 2 of NFT1, subfamily C; Domain 2 of NFT1 (New full-length MRP-type transporter 1). NFT1 belongs to the MRP (multidrug resistance-associated protein) family of ABC transporters. Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional membrane-spanning domains is not clear. The MRP was found in the multidrug-resisting lung cancer cell in which p-glycoprotein was not overexpressed. MRP exports glutathione by drug stimulation, as well as, certain substrates in conjugated forms with anions such as glutathione, glucuronate, and sulfate.


Pssm-ID: 213269 [Multi-domain]  Cd Length: 207  Bit Score: 42.01  E-value: 6.54e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 530785712  57 NLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDpVNVDAVGSYIARELKADV-VLSI 112
Cdd:cd03369  125 NLSQGQRQLLCLARALLKRPRVLVLDEATASID-YATDALIQKTIREEFTNStILTI 180
ABCC_MsbA cd03251
ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; ...
 44-148 6.84e-05

ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213218 [Multi-domain]  Cd Length: 234  Bit Score: 42.22  E-value: 6.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  44 VVGVKGLgskllpNLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIARELKADVVLSIhvpeeAEWL-- 121
Cdd:cd03251  131 VIGERGV------KLSGGQRQRIAIARALLKDPPILILDEATSALDTESERLVQAALERLMKNRTTFVI-----AHRLst 199

                         90       100       110
                 ....*....|....*....|....*....|.
gi 530785712 122 ---GEYFIVLRDGRVAWRGTLEDL-ARENIY 148
Cdd:cd03251  200 ienADRIVVLEDGKIVERGTHEELlAQGGVY 230
MdlB COG1132
ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms];
57-146 9.93e-05

ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms];


Pssm-ID: 440747 [Multi-domain]  Cd Length: 579  Bit Score: 42.46  E-value: 9.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  57 NLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIARELK----------------ADVVlsihvpeeaew 120
Cdd:COG1132  476 NLSGGQRQRIAIARALLKDPPILILDEATSALDTETEALIQEALERLMKgrttiviahrlstirnADRI----------- 544

                         90       100
                 ....*....|....*....|....*.
gi 530785712 121 lgeyfIVLRDGRVAWRGTLEDLAREN 146
Cdd:COG1132  545 -----LVLDDGRIVEQGTHEELLARG 565
ABCC_ATM1_transporter cd03253
ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; ATM1 is an ABC ...
 44-148 1.33e-04

ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; ATM1 is an ABC transporter that is expressed in the mitochondria. Although the specific function of ATM1 is unknown, its disruption results in the accumulation of excess mitochondrial iron, loss of mitochondrial cytochromes, oxidative damage to mitochondrial DNA, and decreased levels of cytosolic heme proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213220 [Multi-domain]  Cd Length: 236  Bit Score: 41.45  E-value: 1.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  44 VVGVKGLgskllpNLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIARELKADVVLSIhvpeeAEWLGE 123
Cdd:cd03253  130 IVGERGL------KLSGGEKQRVAIARAILKNPPILLLDEATSALDTHTEREIQAALRDVSKGRTTIVI-----AHRLST 198

                         90       100       110
                 ....*....|....*....|....*....|.
gi 530785712 124 Y-----FIVLRDGRVAWRGTLEDL-ARENIY 148
Cdd:cd03253  199 IvnadkIIVLKDGRIVERGTHEELlAKGGLY 229
cbiO PRK13648
cobalt transporter ATP-binding subunit; Provisional
 58-142 1.39e-04

cobalt transporter ATP-binding subunit; Provisional


Pssm-ID: 184207 [Multi-domain]  Cd Length: 269  Bit Score: 41.66  E-value: 1.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  58 LSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIaRELKAD---VVLSI-H-VPEEAEwlGEYFIVLRDGR 132
Cdd:PRK13648 143 LSGGQKQRVAIAGVLALNPSVIILDEATSMLDPDARQNLLDLV-RKVKSEhniTIISItHdLSEAME--ADHVIVMNKGT 219

                         90
                 ....*....|
gi 530785712 133 VAWRGTLEDL 142
Cdd:PRK13648 220 VYKEGTPTEI 229
PRK14246 PRK14246
phosphate ABC transporter ATP-binding protein; Provisional
 58-156 1.48e-04

phosphate ABC transporter ATP-binding protein; Provisional


Pssm-ID: 172734 [Multi-domain]  Cd Length: 257  Bit Score: 41.57  E-value: 1.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  58 LSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIArELKAD--VVLSIHVPEEAEWLGEYFIVLRDGRVAW 135
Cdd:PRK14246 154 LSGGQQQRLTIARALALKPKVLLMDEPTSMIDIVNSQAIEKLIT-ELKNEiaIVIVSHNPQQVARVADYVAFLYNGELVE 232

                         90       100
                 ....*....|....*....|....
gi 530785712 136 RGTLEDL---ARENIYEVYVRGHV 156
Cdd:PRK14246 233 WGSSNEIftsPKNELTEKYVIGRI 256
ABC_DrrA cd03265
Daunorubicin/doxorubicin resistance ATP-binding protein; DrrA is the ATP-binding protein ...
 53-142 1.56e-04

Daunorubicin/doxorubicin resistance ATP-binding protein; DrrA is the ATP-binding protein component of a bacterial exporter complex that confers resistance to the antibiotics daunorubicin and doxorubicin. In addition to DrrA, the complex includes an integral membrane protein called DrrB. DrrA belongs to the ABC family of transporters and shares sequence and functional similarities with a protein found in cancer cells called P-glycoprotein. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region in addition to the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213232 [Multi-domain]  Cd Length: 220  Bit Score: 41.20  E-value: 1.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  53 KLLPNLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIaRELKAD----VVLSIHVPEEAEWLGEYFIVL 128
Cdd:cd03265  127 RLVKTYSGGMRRRLEIARSLVHRPEVLFLDEPTIGLDPQTRAHVWEYI-EKLKEEfgmtILLTTHYMEEAEQLCDRVAII 205

                         90
                 ....*....|....
gi 530785712 129 RDGRVAWRGTLEDL 142
Cdd:cd03265  206 DHGRIIAEGTPEEL 219
PLN03232 PLN03232
ABC transporter C family member; Provisional
 57-112 1.94e-04

ABC transporter C family member; Provisional


Pssm-ID: 215640 [Multi-domain]  Cd Length: 1495  Bit Score: 41.50  E-value: 1.94e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 530785712   57 NLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDpVNVDA-VGSYIARELKADVVLSI 112
Cdd:PLN03232 1371 NFSVGQRQLLSLARALLRRSKILVLDEATASVD-VRTDSlIQRTIREEFKSCTMLVI 1426
PLN03130 PLN03130
ABC transporter C family member; Provisional
 57-112 2.01e-04

ABC transporter C family member; Provisional


Pssm-ID: 215595 [Multi-domain]  Cd Length: 1622  Bit Score: 41.65  E-value: 2.01e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 530785712   57 NLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDpVNVDA-VGSYIARELKADVVLSI 112
Cdd:PLN03130 1374 NFSVGQRQLLSLARALLRRSKILVLDEATAAVD-VRTDAlIQKTIREEFKSCTMLII 1429
ABCC_CFTR2 cd03289
ATP-binding cassette domain 2 of CFTR,subfamily C; The cystic fibrosis transmembrane regulator ...
 58-145 2.23e-04

ATP-binding cassette domain 2 of CFTR,subfamily C; The cystic fibrosis transmembrane regulator (CFTR), the product of the gene mutated in patients with cystic fibrosis, has adapted the ABC transporter structural motif to form a tightly regulated anion channel at the apical surface of many epithelia. Use of the term assembly of a functional ion channel implies the coming together of subunits or at least smaller not-yet functional components of the active whole. In fact, on the basis of current knowledge only the CFTR polypeptide itself is required to form an ATP- and protein kinase A-dependent low-conductance chloride channel of the type present in the apical membrane of many epithelial cells. CFTR displays the typical organization (IM-ABC)2 and carries a characteristic hydrophilic R-domain that separates IM1-ABC1 from IM2-ABC2.


Pssm-ID: 213256 [Multi-domain]  Cd Length: 275  Bit Score: 40.99  E-value: 2.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  58 LSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAvgsyIARELK---AD--VVLSIHvPEEAEWLGEYFIVLRDGR 132
Cdd:cd03289  139 LSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPITYQV----IRKTLKqafADctVILSEH-RIEAMLECQRFLVIEENK 213

                         90
                 ....*....|...
gi 530785712 133 VAWRGTLEDLARE 145
Cdd:cd03289  214 VRQYDSIQKLLNE 226
cbiO PRK13632
cobalt transporter ATP-binding subunit; Provisional
 43-150 2.74e-04

cobalt transporter ATP-binding subunit; Provisional


Pssm-ID: 237452 [Multi-domain]  Cd Length: 271  Bit Score: 40.74  E-value: 2.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  43 DVVGVKGLGSKLLPNLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIA--RELKADVVLSI-HVPEEAe 119
Cdd:PRK13632 128 KKVGMEDYLDKEPQNLSGGQKQRVAIASVLALNPEIIIFDESTSMLDPKGKREIKKIMVdlRKTRKKTLISItHDMDEA- 206

                         90       100       110
                 ....*....|....*....|....*....|..
gi 530785712 120 WLGEYFIVLRDGRVAWRGT-LEDLARENIYEV 150
Cdd:PRK13632 207 ILADKVIVFSEGKLIAQGKpKEILNNKEILEK 238
PTZ00243 PTZ00243
ABC transporter; Provisional
 45-149 2.91e-04

ABC transporter; Provisional


Pssm-ID: 240327 [Multi-domain]  Cd Length: 1560  Bit Score: 41.30  E-value: 2.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712   45 VGVKGLgskllpNLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPvnvdAVGSYIAREL-------KADVVLS--IHVP 115
Cdd:PTZ00243  776 IGEKGV------NLSGGQKARVSLARAVYANRDVYLLDDPLSALDA----HVGERVVEECflgalagKTRVLAThqVHVV 845

                          90       100       110
                  ....*....|....*....|....*....|....
gi 530785712  116 EEAEwlgeYFIVLRDGRVAWRGTLEDLARENIYE 149
Cdd:PTZ00243  846 PRAD----YVVALGDGRVEFSGSSADFMRTSLYA 875
ABC_Metallic_Cations cd03235
ATP-binding cassette domain of the metal-type transporters; This family includes transporters ...
 45-113 3.56e-04

ATP-binding cassette domain of the metal-type transporters; This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-siderophore uptake family suggesting that they share a common ancestor. The best characterized metal-type ABC transporters are the YfeABCD system of Y. pestis, the SitABCD system of Salmonella enterica serovar Typhimurium, and the SitABCD transporter of Shigella flexneri. Moreover other uncharacterized homologs of these metal-type transporters are mainly found in pathogens like Haemophilus or enteroinvasive E. coli isolates.


Pssm-ID: 213202 [Multi-domain]  Cd Length: 213  Bit Score: 39.82  E-value: 3.56e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530785712  45 VGVKGLGSKLLPNLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIaRELKAD---VVLSIH 113
Cdd:cd03235  120 VGLSELADRQIGELSGGQQQRVLLARALVQDPDLLLLDEPFAGVDPKTQEDIYELL-RELRREgmtILVVTH 190
MglA COG1129
ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism];
57-191 3.85e-04

ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism];


Pssm-ID: 440745 [Multi-domain]  Cd Length: 497  Bit Score: 40.39  E-value: 3.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  57 NLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSyIARELKADVVLSI---HVPEEAEWLGEYFIVLRDGRV 133
Cdd:COG1129  140 DLSVAQQQLVEIARALSRDARVLILDEPTASLTEREVERLFR-IIRRLKAQGVAIIyisHRLDEVFEIADRVTVLRDGRL 218

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530785712 134 AWRGTLEDLARENIyevyVRGHVPEGLEVVaslgYVALVRASEDVLFE---LNSRGVIRGF 191
Cdd:COG1129  219 VGTGPVAELTEDEL----VRLMVGRELEDL----FPKRAAAPGEVVLEvegLSVGGVVRDV 271
PRK10851 PRK10851
sulfate/thiosulfate ABC transporter ATP-binding protein CysA;
58-145 4.81e-04

sulfate/thiosulfate ABC transporter ATP-binding protein CysA;


Pssm-ID: 182778 [Multi-domain]  Cd Length: 353  Bit Score: 40.07  E-value: 4.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  58 LSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIAR---ELKADVVLSIHVPEEAEWLGEYFIVLRDGRVA 134
Cdd:PRK10851 137 LSGGQKQRVALARALAVEPQILLLDEPFGALDAQVRKELRRWLRQlheELKFTSVFVTHDQEEAMEVADRVVVMSQGNIE 216

                         90
                 ....*....|.
gi 530785712 135 WRGTLEDLARE 145
Cdd:PRK10851 217 QAGTPDQVWRE 227
cbiO PRK13652
cobalt transporter ATP-binding subunit; Provisional
 10-142 5.25e-04

cobalt transporter ATP-binding subunit; Provisional


Pssm-ID: 172200 [Multi-domain]  Cd Length: 277  Bit Score: 39.79  E-value: 5.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  10 FLPTIIYYVAYYPGLKSLHDSDVYHGdcLEFFWDVVGVKGLGSKLLPNLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLD 89
Cdd:PRK13652  92 FSPTVEQDIAFGPINLGLDEETVAHR--VSSALHMLGLEELRDRVPHHLSGGEKKRVAIAGVIAMEPQVLVLDEPTAGLD 169

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 530785712  90 PVNVDAVGSYIAR---ELKADVVLSIHVPEEAEWLGEYFIVLRDGRVAWRGTLEDL 142
Cdd:PRK13652 170 PQGVKELIDFLNDlpeTYGMTVIFSTHQLDLVPEMADYIYVMDKGRIVAYGTVEEI 225
met_CoM_red_A2 TIGR03269
methyl coenzyme M reductase system, component A2; The enzyme that catalyzes the final step in ...
 57-138 5.54e-04

methyl coenzyme M reductase system, component A2; The enzyme that catalyzes the final step in methanogenesis, methyl coenzyme M reductase, contains alpha, beta, and gamma chains. In older literature, the complex of alpha, beta, and gamma chains was termed component C, while this single chain protein was termed methyl coenzyme M reductase system component A2. [Energy metabolism, Methanogenesis]


Pssm-ID: 132313 [Multi-domain]  Cd Length: 520  Bit Score: 40.17  E-value: 5.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712   57 NLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIARELKAD---VVLSIHVPEEAEWLGEYFIVLRDGRV 133
Cdd:TIGR03269 168 DLSGGEKQRVVLARQLAKEPFLFLADEPTGTLDPQTAKLVHNALEEAVKASgisMVLTSHWPEVIEDLSDKAIWLENGEI 247


                  ....*
gi 530785712  134 AWRGT 138
Cdd:TIGR03269 248 KEEGT 252
PRK09984 PRK09984
phosphonate ABC transporter ATP-binding protein;
45-151 6.34e-04

phosphonate ABC transporter ATP-binding protein;


Pssm-ID: 182182 [Multi-domain]  Cd Length: 262  Bit Score: 39.61  E-value: 6.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  45 VGVKGLGSKLLPNLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIARELKAD---VVLSIHVPEEAEWL 121
Cdd:PRK09984 140 VGMVHFAHQRVSTLSGGQQQRVAIARALMQQAKVILADEPIASLDPESARIVMDTLRDINQNDgitVVVTLHQVDYALRY 219

                         90       100       110
                 ....*....|....*....|....*....|
gi 530785712 122 GEYFIVLRDGRVAWRGTLEDLARENIYEVY 151
Cdd:PRK09984 220 CERIVALRQGHVFYDGSSQQFDNERFDHLY 249
ABC_CysA_sulfate_importer cd03296
ATP-binding cassette domain of the sulfate transporter; Part of the ABC transporter complex ...
 43-142 6.68e-04

ATP-binding cassette domain of the sulfate transporter; Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a solute-binding protein (cysP). ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213263 [Multi-domain]  Cd Length: 239  Bit Score: 39.24  E-value: 6.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  43 DVVGVKGLGSKLLPNLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIAR---ELKADVVLSIHVPEEAE 119
Cdd:cd03296  122 KLVQLDWLADRYPAQLSGGQRQRVALARALAVEPKVLLLDEPFGALDAKVRKELRRWLRRlhdELHVTTVFVTHDQEEAL 201

                         90       100
                 ....*....|....*....|...
gi 530785712 120 WLGEYFIVLRDGRVAWRGTLEDL 142
Cdd:cd03296  202 EVADRVVVMNKGRIEQVGTPDEV 224
ABC_MetN_methionine_transporter cd03258
ATP-binding cassette domain of methionine transporter; MetN (also known as YusC) is an ...
 57-142 6.88e-04

ATP-binding cassette domain of methionine transporter; MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213225 [Multi-domain]  Cd Length: 233  Bit Score: 39.10  E-value: 6.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  57 NLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVG---SYIARELKADVVLSIHVPEEAEWLGEYFIVLRDGRV 133
Cdd:cd03258  140 QLSGGQKQRVGIARALANNPKVLLCDEATSALDPETTQSILallRDINRELGLTIVLITHEMEVVKRICDRVAVMEKGEV 219


                 ....*....
gi 530785712 134 AWRGTLEDL 142
Cdd:cd03258  220 VEEGTVEEV 228
PRK14267 PRK14267
phosphate ABC transporter ATP-binding protein; Provisional
 57-133 7.02e-04

phosphate ABC transporter ATP-binding protein; Provisional


Pssm-ID: 184596 [Multi-domain]  Cd Length: 253  Bit Score: 39.44  E-value: 7.02e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530785712  57 NLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIArELKAD--VVLSIHVPEEAEWLGEYFIVLRDGRV 133
Cdd:PRK14267 149 NLSGGQRQRLVIARALAMKPKILLMDEPTANIDPVGTAKIEELLF-ELKKEytIVLVTHSPAQAARVSDYVAFLYLGKL 226
PRK14271 PRK14271
phosphate ABC transporter ATP-binding protein; Provisional
 41-142 8.25e-04

phosphate ABC transporter ATP-binding protein; Provisional


Pssm-ID: 172759 [Multi-domain]  Cd Length: 276  Bit Score: 39.31  E-value: 8.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  41 FWDVVGVKGLGSKLlpNLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIaREL--KADVVLSIHVPEEA 118
Cdd:PRK14271 149 LWDAVKDRLSDSPF--RLSGGQQQLLCLARTLAVNPEVLLLDEPTSALDPTTTEKIEEFI-RSLadRLTVIIVTHNLAQA 225

                         90       100
                 ....*....|....*....|....
gi 530785712 119 EWLGEYFIVLRDGRVAWRGTLEDL 142
Cdd:PRK14271 226 ARISDRAALFFDGRLVEEGPTEQL 249
PRK11176 PRK11176
lipid A ABC transporter ATP-binding protein/permease MsbA;
58-148 8.34e-04

lipid A ABC transporter ATP-binding protein/permease MsbA;


Pssm-ID: 183016 [Multi-domain]  Cd Length: 582  Bit Score: 39.62  E-value: 8.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  58 LSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIArELKAD-VVLSI-HVPEEAEWLGEyFIVLRDGRVAW 135
Cdd:PRK11176 481 LSGGQRQRIAIARALLRDSPILILDEATSALDTESERAIQAALD-ELQKNrTSLVIaHRLSTIEKADE-ILVVEDGEIVE 558

                         90
                 ....*....|....
gi 530785712 136 RGTLEDL-ARENIY 148
Cdd:PRK11176 559 RGTHAELlAQNGVY 572
ABC_MTABC3_MDL1_MDL2 cd03249
ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; MTABC3 ...
 58-153 8.54e-04

ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the yeast MDL1 (multidrug resistance-like protein 1) and MDL2 (multidrug resistance-like protein 2) transporters are also included in this CD. MDL1 is an ATP-dependent permease that acts as a high-copy suppressor of ATM1 and is thought to have a role in resistance to oxidative stress. Interestingly, subfamily B is more closely related to the carboxyl-terminal component of subfamily C than the two halves of ABCC molecules are with one another.


Pssm-ID: 213216 [Multi-domain]  Cd Length: 238  Bit Score: 39.06  E-value: 8.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  58 LSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIARELKADVVLSI----HVPEEAEWLgeyfIVLRDGRV 133
Cdd:cd03249  140 LSGGQKQRIAIARALLRNPKILLLDEATSALDAESEKLVQEALDRAMKGRTTIVIahrlSTIRNADLI----AVLQNGQV 215

                         90       100
                 ....*....|....*....|.
gi 530785712 134 AWRGTLEDL-ARENIYEVYVR 153
Cdd:cd03249  216 VEQGTHDELmAQKGVYAKLVK 236
araG PRK11288
L-arabinose ABC transporter ATP-binding protein AraG;
48-162 9.68e-04

L-arabinose ABC transporter ATP-binding protein AraG;


Pssm-ID: 183077 [Multi-domain]  Cd Length: 501  Bit Score: 39.51  E-value: 9.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  48 KGLGSKLLPN-----LSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIaRELKAD--VVLSI-HVPEEAE 119
Cdd:PRK11288 126 EHLGVDIDPDtplkyLSIGQRQMVEIAKALARNARVIAFDEPTSSLSAREIEQLFRVI-RELRAEgrVILYVsHRMEEIF 204

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 530785712 120 WLGEYFIVLRDGR-VAWRGTLEDLARE------------NIYEVYVRGHVPEGLEV 162
Cdd:PRK11288 205 ALCDAITVFKDGRyVATFDDMAQVDRDqlvqamvgreigDIYGYRPRPLGEVRLRL 260
cbiO PRK13636
cobalt transporter ATP-binding subunit; Provisional
 46-161 1.13e-03

cobalt transporter ATP-binding subunit; Provisional


Pssm-ID: 184196 [Multi-domain]  Cd Length: 283  Bit Score: 38.68  E-value: 1.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  46 GVKGLGSKLLPNLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYI---ARELKADVVLSIHVPEEAEWLG 122
Cdd:PRK13636 130 GIEHLKDKPTHCLSFGQKKRVAIAGVLVMEPKVLVLDEPTAGLDPMGVSEIMKLLvemQKELGLTIIIATHDIDIVPLYC 209

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 530785712 123 EYFIVLRDGRVAWRGTLEDL--ARENIYEVYVR----GHVPEGLE 161
Cdd:PRK13636 210 DNVFVMKEGRVILQGNPKEVfaEKEMLRKVNLRlpriGHLMEILK 254
PRK13536 PRK13536
nodulation factor ABC transporter ATP-binding protein NodI;
58-198 1.31e-03

nodulation factor ABC transporter ATP-binding protein NodI;


Pssm-ID: 237419 [Multi-domain]  Cd Length: 340  Bit Score: 38.66  E-value: 1.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  58 LSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDP----VNVDAVGSYIARelKADVVLSIHVPEEAEWLGEYFIVLRDGRV 133
Cdd:PRK13536 173 LSGGMKRRLTLARALINDPQLLILDEPTTGLDPharhLIWERLRSLLAR--GKTILLTTHFMEEAERLCDRLCVLEAGRK 250

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530785712 134 AWRGTLEDLARENI----YEVYvrGHVPEGLEVVASlGYVALVRASEDVLFELNS-----RGVIRGfrRAGVRV 198
Cdd:PRK13536 251 IAEGRPHALIDEHIgcqvIEIY--GGDPHELSSLVK-PYARRIEVSGETLFCYAPdpeqvRVQLRG--RAGLRL 319
ABC_MalK_N cd03301
The N-terminal ATPase domain of the maltose transporter, MalK; ATP binding cassette (ABC) ...
 58-133 1.88e-03

The N-terminal ATPase domain of the maltose transporter, MalK; ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two transmembrane-spanning domains (TMDs) or subunits and two nucleotide binding domains (NBDs) or subunits that couple transport to the hydrolysis of ATP. In the maltose transport system, the periplasmic maltose binding protein (MBP) stimulates the ATPase activity of the membrane-associated transporter, which consists of two transmembrane subunits, MalF and MalG, and two copies of the ATP binding subunit, MalK, and becomes tightly bound to the transporter in the catalytic transition state, ensuring that maltose is passed to the transporter as ATP is hydrolyzed.


Pssm-ID: 213268 [Multi-domain]  Cd Length: 213  Bit Score: 38.00  E-value: 1.88e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530785712  58 LSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDP---VNVDAVGSYIARELKADVVLSIHVPEEAEWLGEYFIVLRDGRV 133
Cdd:cd03301  131 LSGGQRQRVALGRAIVREPKVFLMDEPLSNLDAklrVQMRAELKRLQQRLGTTTIYVTHDQVEAMTMADRIAVMNDGQI 209
ABC_PstB_phosphate_transporter cd03260
ATP-binding cassette domain of the phosphate transport system; Phosphate uptake is of ...
 58-133 1.92e-03

ATP-binding cassette domain of the phosphate transport system; Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein is a phosphate-binding protein located in the periplasmic space. PstA and PstC are hydrophobic and they form the transmembrane portion of the Pst system. PstB is the catalytic subunit, which couples the energy of ATP hydrolysis to the import of phosphate across cellular membranes through the Pst system, often referred as ABC-protein. PstB belongs to one of the largest superfamilies of proteins characterized by a highly conserved adenosine triphosphate (ATP) binding cassette (ABC), which is also a nucleotide binding domain (NBD).


Pssm-ID: 213227 [Multi-domain]  Cd Length: 227  Bit Score: 37.93  E-value: 1.92e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530785712  58 LSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIaRELKAD--VVLSIHVPEEAEWLGEYFIVLRDGRV 133
Cdd:cd03260  142 LSGGQQQRLCLARALANEPEVLLLDEPTSALDPISTAKIEELI-AELKKEytIVIVTHNMQQAARVADRTAFLLNGRL 218
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 27-100 2.52e-03

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 38.41  E-value: 2.52e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530785712    27 LHDSDVYHGDCLEFFwdvVGVKGLGSKLLPNLSSGQKQLVQL-----MQGlCRVSKIKVLDEAFSHLDPVNVDAVGSYI 100
Cdd:pfam02463 1050 LEDPDDPFSGGIEIS---ARPPGKGVKNLDLLSGGEKTLVALalifaIQK-YKPAPFYLLDEIDAALDDQNVSRVANLL 1124
MlaF COG1127
ATPase subunit MlaF of the ABC-type intermembrane phospholipid transporter Mla [Cell wall ...
 81-144 3.08e-03

ATPase subunit MlaF of the ABC-type intermembrane phospholipid transporter Mla [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440744 [Multi-domain]  Cd Length: 241  Bit Score: 37.27  E-value: 3.08e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530785712  81 LDEAFSHLDPVNVDAVGSYIA---RELKADVVLSIHVPEEAEWLGEYFIVLRDGRVAWRGTLEDLAR 144
Cdd:COG1127  165 YDEPTAGLDPITSAVIDELIRelrDELGLTSVVVTHDLDSAFAIADRVAVLADGKIIAEGTPEELLA 231
PRK10619 PRK10619
histidine ABC transporter ATP-binding protein HisP;
39-142 3.17e-03

histidine ABC transporter ATP-binding protein HisP;


Pssm-ID: 182592 [Multi-domain]  Cd Length: 257  Bit Score: 37.26  E-value: 3.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  39 EFFWDVVGVKGLGSKLLP-NLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAV---GSYIARELKADVVLSiHV 114
Cdd:PRK10619 133 VKYLAKVGIDERAQGKYPvHLSGGQQQRVSIARALAMEPEVLLFDEPTSALDPELVGEVlriMQQLAEEGKTMVVVT-HE 211

                         90       100
                 ....*....|....*....|....*...
gi 530785712 115 PEEAEWLGEYFIVLRDGRVAWRGTLEDL 142
Cdd:PRK10619 212 MGFARHVSSHVIFLHQGKIEEEGAPEQL 239
PRK10070 PRK10070
proline/glycine betaine ABC transporter ATP-binding protein ProV;
45-153 3.64e-03

proline/glycine betaine ABC transporter ATP-binding protein ProV;


Pssm-ID: 182221 [Multi-domain]  Cd Length: 400  Bit Score: 37.71  E-value: 3.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  45 VGVKGLGSKLLPNLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPV----NVDAVGSYIARELKADVVLSiHVPEEAEW 120
Cdd:PRK10070 152 VGLENYAHSYPDELSGGMRQRVGLARALAINPDILLMDEAFSALDPLirteMQDELVKLQAKHQRTIVFIS-HDLDEAMR 230

                         90       100       110
                 ....*....|....*....|....*....|...
gi 530785712 121 LGEYFIVLRDGRVAWRGTLEDLArENIYEVYVR 153
Cdd:PRK10070 231 IGDRIAIMQNGEVVQVGTPDEIL-NNPANDYVR 262
ABC_NrtD_SsuB_transporters cd03293
ATP-binding cassette domain of the nitrate and sulfonate transporters; NrtD and SsuB are the ...
 45-134 3.71e-03

ATP-binding cassette domain of the nitrate and sulfonate transporters; NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213260 [Multi-domain]  Cd Length: 220  Bit Score: 37.07  E-value: 3.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  45 VGVKGLGSKLLPNLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSY---IARELKADVVLSIHVPEEAEWL 121
Cdd:cd03293  119 VGLSGFENAYPHQLSGGMRQRVALARALAVDPDVLLLDEPFSALDALTREQLQEElldIWRETGKTVLLVTHDIDEAVFL 198

                         90
                 ....*....|....*
gi 530785712 122 GEYFIVL--RDGRVA 134
Cdd:cd03293  199 ADRVVVLsaRPGRIV 213
ABC_PotA_N cd03300
ATP-binding cassette domain of the polyamine transporter; PotA is an ABC-type transporter and ...
 43-149 3.88e-03

ATP-binding cassette domain of the polyamine transporter; PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required for homodimerization with PotA and heterdimerization with PotB. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213267 [Multi-domain]  Cd Length: 232  Bit Score: 37.22  E-value: 3.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  43 DVVGVKGLGSKLLPNLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLD-------PVNVDAvgsyIARELKADVVLSIHVP 115
Cdd:cd03300  116 DLVQLEGYANRKPSQLSGGQQQRVAIARALVNEPKVLLLDEPLGALDlklrkdmQLELKR----LQKELGITFVFVTHDQ 191

                         90       100       110
                 ....*....|....*....|....*....|....
gi 530785712 116 EEAEWLGEYFIVLRDGRVAWRGTLEDlarenIYE 149
Cdd:cd03300  192 EEALTMSDRIAVMNKGKIQQIGTPEE-----IYE 220
ABC_CcmA_heme_exporter cd03231
Cytochrome c biogenesis ATP-binding export protein; CcmA, the ATP-binding component of the ...
 15-115 4.67e-03

Cytochrome c biogenesis ATP-binding export protein; CcmA, the ATP-binding component of the bacterial CcmAB transporter. The CCM family is involved in bacterial cytochrome c biogenesis. Cytochrome c maturation in E. coli requires the ccm operon, which encodes eight membrane proteins (CcmABCDEFGH). CcmE is a periplasmic heme chaperon that binds heme covalently and transfers it onto apocytochrome c in the presence of CcmF, CcmG, and CcmH. The CcmAB proteins represent an ABC transporter and the CcmCD proteins participate in heme transfer to CcmE.


Pssm-ID: 213198 [Multi-domain]  Cd Length: 201  Bit Score: 36.70  E-value: 4.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  15 IYYVAYYPGLKS----LHDSDVYHGDC----LEFFWDVVGVKGLGSKLLPNLSSGQKQLVQLMQGLCRVSKIKVLDEAFS 86
Cdd:cd03231   75 LLYLGHAPGIKTtlsvLENLRFWHADHsdeqVEEALARVGLNGFEDRPVAQLSAGQQRRVALARLLLSGRPLWILDEPTT 154

                         90       100       110
                 ....*....|....*....|....*....|.
gi 530785712  87 HLDPVNVDAVGSYIARELKAD--VVLSIHVP 115
Cdd:cd03231  155 ALDKAGVARFAEAMAGHCARGgmVVLTTHQD 185
PRK09700 PRK09700
D-allose ABC transporter ATP-binding protein AlsA;
43-152 5.37e-03

D-allose ABC transporter ATP-binding protein AlsA;


Pssm-ID: 182036 [Multi-domain]  Cd Length: 510  Bit Score: 37.07  E-value: 5.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  43 DVVGVKGLGSKLLPNLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVgSYIARELKAD---VVLSIHVPEEAE 119
Cdd:PRK09700 131 LRVGLKVDLDEKVANLSISHKQMLEIAKTLMLDAKVIIMDEPTSSLTNKEVDYL-FLIMNQLRKEgtaIVYISHKLAEIR 209

                         90       100       110
                 ....*....|....*....|....*....|...
gi 530785712 120 WLGEYFIVLRDGRVAWRGTLEDLARENIYEVYV 152
Cdd:PRK09700 210 RICDRYTVMKDGSSVCSGMVSDVSNDDIVRLMV 242
CFTR_protein TIGR01271
cystic fibrosis transmembrane conductor regulator (CFTR); The model describes the cystis ...
 58-113 5.82e-03

cystic fibrosis transmembrane conductor regulator (CFTR); The model describes the cystis fibrosis transmembrane conductor regulator (CFTR) in eukaryotes. The principal role of this protein is chloride ion conductance. The protein is predicted to consist of 12 transmembrane domains. Mutations or lesions in the genetic loci have been linked to the aetiology of asthma, bronchiectasis, chronic obstructive pulmonary disease etc. Disease-causing mutations have been studied by 36Cl efflux assays in vitro cell cultures and electrophysiology, all of which point to the impairment of chloride channel stability and not the biosynthetic processing per se. [Transport and binding proteins, Anions]


Pssm-ID: 273530 [Multi-domain]  Cd Length: 1490  Bit Score: 37.20  E-value: 5.82e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530785712    58 LSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAvgsyIARELK-----ADVVLSIH 113
Cdd:TIGR01271 1354 LSNGHKQLMCLARSILSKAKILLLDEPSAHLDPVTLQI----IRKTLKqsfsnCTVILSEH 1410
PRK10790 PRK10790
SmdB family multidrug efflux ABC transporter permease/ATP-binding protein;
57-151 6.08e-03

SmdB family multidrug efflux ABC transporter permease/ATP-binding protein;


Pssm-ID: 182733 [Multi-domain]  Cd Length: 592  Bit Score: 37.00  E-value: 6.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  57 NLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIA--RELKADVV----LSIHVpeEAEWLgeyfIVLRD 130
Cdd:PRK10790 476 NLSVGQKQLLALARVLVQTPQILILDEATANIDSGTEQAIQQALAavREHTTLVViahrLSTIV--EADTI----LVLHR 549

                         90       100
                 ....*....|....*....|...
gi 530785712 131 GRVAWRGTLEDL--ARENIYEVY 151
Cdd:PRK10790 550 GQAVEQGTHQQLlaAQGRYWQMY 572
ABCC_Hemolysin cd03252
ATP-binding cassette domain of hemolysin B, subfamily C; The ABC-transporter hemolysin B is a ...
 44-146 6.72e-03

ATP-binding cassette domain of hemolysin B, subfamily C; The ABC-transporter hemolysin B is a central component of the secretion machinery that translocates the toxin, hemolysin A, in a Sec-independent fashion across both membranes of E. coli. The hemolysin A (HlyA) transport machinery is composed of the ATP-binding cassette (ABC) transporter HlyB located in the inner membrane, hemolysin D (HlyD), also anchored in the inner membrane, and TolC, which resides in the outer membrane. HlyD apparently forms a continuous channel that bridges the entire periplasm, interacting with TolC and HlyB. This arrangement prevents the appearance of periplasmic intermediates of HlyA during substrate transport. Little is known about the molecular details of HlyA transport, but it is evident that ATP-hydrolysis by the ABC-transporter HlyB is a necessary source of energy.


Pssm-ID: 213219 [Multi-domain]  Cd Length: 237  Bit Score: 36.31  E-value: 6.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  44 VVGVKGLGskllpnLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVGSYIARELKADVVLSIHVPEEAEWLGE 123
Cdd:cd03252  131 IVGEQGAG------LSGGQRQRIAIARALIHNPRILIFDEATSALDYESEHAIMRNMHDICAGRTVIIIAHRLSTVKNAD 204

                         90       100
                 ....*....|....*....|...
gi 530785712 124 YFIVLRDGRVAWRGTLEDLAREN 146
Cdd:cd03252  205 RIIVMEKGRIVEQGSHDELLAEN 227
MK0520 COG2401
ABC-type ATPase fused to a predicted acetyltransferase domain [General function prediction ...
 57-121 8.95e-03

ABC-type ATPase fused to a predicted acetyltransferase domain [General function prediction only];


Pssm-ID: 441957 [Multi-domain]  Cd Length: 222  Bit Score: 36.09  E-value: 8.95e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530785712  57 NLSSGQKQLVQLMQGLCRVSKIKVLDEAFSHLDPVNVDAVG---SYIARELKADVVLSIHVPEEAEWL 121
Cdd:COG2401  136 ELSTGQKFRFRLALLLAERPKLLVIDEFCSHLDRQTAKRVArnlQKLARRAGITLVVATHHYDVIDDL 203
metN PRK11153
DL-methionine transporter ATP-binding subunit; Provisional
 57-150 9.93e-03

DL-methionine transporter ATP-binding subunit; Provisional


Pssm-ID: 236863 [Multi-domain]  Cd Length: 343  Bit Score: 35.93  E-value: 9.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530785712  57 NLSSGQKQLVqlmqGLCRV--SKIKVL--DEAFSHLDPVNVDAVGSYIA---RELKADVVLSIHVPEEAEWLGEYFIVLR 129
Cdd:PRK11153 140 QLSGGQKQRV----AIARAlaSNPKVLlcDEATSALDPATTRSILELLKdinRELGLTIVLITHEMDVVKRICDRVAVID 215

                         90       100
                 ....*....|....*....|....*....
gi 530785712 130 DGRVAWRGTLED--------LARENIYEV 150
Cdd:PRK11153 216 AGRLVEQGTVSEvfshpkhpLTREFIQST 244
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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