NCBI Conserved Domain Search

Conserved domains on [gi|523689182|ref|WP_020808188|]

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ABC transporter ATP-binding protein [Agrobacterium tumefaciens]

Protein Classification

ABC transporter ATP-binding protein( domain architecture ID 11418519)

ABC transporter ATP-binding protein is the ATPase catalytic subunit of an ATP transporter complex responsible for coupling the energy of ATP hydrolysis to the import of one or more from a variety of substrates including dipeptides and oligopeptides

CATH: 3.40.50.300

Gene Ontology: GO:0042626|GO:0140359|GO:0016887

PubMed: 25750732|24638992

SCOP: 4003976

TCDB: 3.A.1

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

DppD

COG0444

ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid ...

8-323

4.73e-177

ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];

Pssm-ID: 440213 [Multi-domain] Cd Length: 320 Bit Score: 492.26 E-value: 4.73e-177

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSVTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGTLIEGGMTVDGHDIMSLSNRAL 87
Cdd:COG0444    1 LLEVRNLKVYFPTRRGVVKAVDGVSFDVRRGETLGLVGESGSGKSTLARAILGLLPPPGITSGEILFDGEDLLKLSEKEL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  88 SDLRGAVVSMVFQEPRLALDPVYTVGRQIEETIMRHEKVSRGLAAERALALFQKVRIPSPERRLSNYPHEMSGGMLQRAM 167
Cdd:COG0444   81 RKIRGREIQMIFQDPMTSLNPVMTVGDQIAEPLRIHGGLSKAEARERAIELLERVGLPDPERRLDRYPHELSGGMRQRVM 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 168 IAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDIIR 247
Cdd:COG0444  161 IARALALEPKLLIADEPTTALDVTIQAQILNLLKDLQRELGLAILFITHDLGVVAEIADRVAVMYAGRIVEEGPVEELFE 240

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 523689182 248 NPRHPYTKGLLGARVELAEGRDRLVTIPGAPPDLAAMPPGCAFAPRCVQVSDLCQKQIPPLLPLSGGAGVACLFPD 323
Cdd:COG0444  241 NPRHPYTRALLSSIPRLDPDGRRLIPIPGEPPSLLNPPSGCRFHPRCPYAMDRCREEEPPLREVGPGHRVACHLYE 316

Name

Accession

Description

Interval

E-value

DppD

COG0444

ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid ...

8-323

4.73e-177

ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];

Pssm-ID: 440213 [Multi-domain] Cd Length: 320 Bit Score: 492.26 E-value: 4.73e-177

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSVTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGTLIEGGMTVDGHDIMSLSNRAL 87
Cdd:COG0444    1 LLEVRNLKVYFPTRRGVVKAVDGVSFDVRRGETLGLVGESGSGKSTLARAILGLLPPPGITSGEILFDGEDLLKLSEKEL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  88 SDLRGAVVSMVFQEPRLALDPVYTVGRQIEETIMRHEKVSRGLAAERALALFQKVRIPSPERRLSNYPHEMSGGMLQRAM 167
Cdd:COG0444   81 RKIRGREIQMIFQDPMTSLNPVMTVGDQIAEPLRIHGGLSKAEARERAIELLERVGLPDPERRLDRYPHELSGGMRQRVM 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 168 IAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDIIR 247
Cdd:COG0444  161 IARALALEPKLLIADEPTTALDVTIQAQILNLLKDLQRELGLAILFITHDLGVVAEIADRVAVMYAGRIVEEGPVEELFE 240

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 523689182 248 NPRHPYTKGLLGARVELAEGRDRLVTIPGAPPDLAAMPPGCAFAPRCVQVSDLCQKQIPPLLPLSGGAGVACLFPD 323
Cdd:COG0444  241 NPRHPYTRALLSSIPRLDPDGRRLIPIPGEPPSLLNPPSGCRFHPRCPYAMDRCREEEPPLREVGPGHRVACHLYE 316

oppD

PRK09473

oligopeptide transporter ATP-binding component; Provisional

4-322

5.60e-112

oligopeptide transporter ATP-binding component; Provisional

Pssm-ID: 181888 [Multi-domain] Cd Length: 330 Bit Score: 327.84 E-value: 5.60e-112

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   4 QNDAMIDISNLSVTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGTLIEGGMTVDGHDIMSLS 83
Cdd:PRK09473   8 QADALLDVKDLRVTFSTPDGDVTAVNDLNFSLRAGETLGIVGESGSGKSQTAFALMGLLAANGRIGGSATFNGREILNLP 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  84 NRALSDLRGAVVSMVFQEPRLALDPVYTVGRQIEETIMRHEKVSRGLAAERALALFQKVRIPSPERRLSNYPHEMSGGML 163
Cdd:PRK09473  88 EKELNKLRAEQISMIFQDPMTSLNPYMRVGEQLMEVLMLHKGMSKAEAFEESVRMLDAVKMPEARKRMKMYPHEFSGGMR 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 164 QRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVG 243
Cdd:PRK09473 168 QRVMIAMALLCRPKLLIADEPTTALDVTVQAQIMTLLNELKREFNTAIIMITHDLGVVAGICDKVLVMYAGRTMEYGNAR 247

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 523689182 244 DIIRNPRHPYTKGLLGARVELAEGRDRLVTIPGAPPDLAAMPPGCAFAPRCVQVSDLCQkQIPPLLPLSGGAGVACLFP 322
Cdd:PRK09473 248 DVFYQPSHPYSIGLLNAVPRLDAEGESLLTIPGNPPNLLRLPKGCPFQPRCPHAMEICS-SAPPLEEFGPGRLRACFKP 325

ABC_NikE_OppD_transporters

cd03257

ATP-binding cassette domain of nickel/oligopeptides specific transporters; The ABC transporter ...

8-240

1.23e-111

ATP-binding cassette domain of nickel/oligopeptides specific transporters; The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane components (NikB and NikC), and two ATPase (NikD and NikE). The NikABCDE transporter is synthesized under anaerobic conditions to meet the increased demand for nickel resulting from hydrogenase synthesis. The molecular mechanism of nickel uptake in many bacteria and most archaea is not known. Many other members of this ABC family are also involved in the uptake of dipeptides and oligopeptides. The oligopeptide transport system (Opp) is a five-component ABC transport composed of a membrane-anchored substrate binding proteins (SRP), OppA, two transmembrane proteins, OppB and OppC, and two ATP-binding domains, OppD and OppF.

Pssm-ID: 213224 [Multi-domain] Cd Length: 228 Bit Score: 323.30 E-value: 1.23e-111

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSVTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKgtlIEGGMTVDGHDIMSLSNRAL 87
Cdd:cd03257    1 LLEVKNLSVSFPTGGGSVKALDDVSFSIKKGETLGLVGESGSGKSTLARAILGLLKP---TSGSIIFDGKDLLKLSRRLR 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  88 SdLRGAVVSMVFQEPRLALDPVYTVGRQIEETIMRHEKVSRGLAAERALALfQKVRIPSPERRLSNYPHEMSGGMLQRAM 167
Cdd:cd03257   78 K-IRRKEIQMVFQDPMSSLNPRMTIGEQIAEPLRIHGKLSKKEARKEAVLL-LLVGVGLPEEVLNRYPHELSGGQRQRVA 155

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 523689182 168 IAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEG 240
Cdd:cd03257  156 IARALALNPKLLIADEPTSALDVSVQAQILDLLKKLQEELGLTLLFITHDLGVVAKIADRVAVMYAGKIVEEG 228

nickel_nikD

TIGR02770

nickel import ATP-binding protein NikD; This family represents the NikD subunit of a ...

27-261

2.03e-81

nickel import ATP-binding protein NikD; This family represents the NikD subunit of a multisubunit nickel import ABC transporter complex. Nickel, once imported, may be used in urease and in certain classes of hydrogenase and superoxide dismutase. NikD and NikE are homologous. [Transport and binding proteins, Cations and iron carrying compounds]

Pssm-ID: 131817 [Multi-domain] Cd Length: 230 Bit Score: 246.51 E-value: 2.03e-81

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   27 AVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGTLI-EGGMTVDGHDIMSLSnralsdLRGAVVSMVFQEPRLA 105
Cdd:TIGR02770   1 LVQDLNLSLKRGEVLALVGESGSGKSLTCLAILGLLPPGLTQtSGEILLDGRPLLPLS------IRGRHIATIMQNPRTA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  106 LDPVYTVGRQIEETIMRHEKVSRGlAAERALALFQKVRIPSPERRLSNYPHEMSGGMLQRAMIAMALACNPKVLLADEPT 185
Cdd:TIGR02770  75 FNPLFTMGNHAIETLRSLGKLSKQ-ARALILEALEAVGLPDPEEVLKKYPFQLSGGMLQRVMIALALLLEPPFLIADEPT 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 523689182  186 TALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDIIRNPRHPYTKGLLGAR 261
Cdd:TIGR02770 154 TDLDVVNQARVLKLLRELRQLFGTGILLITHDLGVVARIADEVAVMDDGRIVERGTVKEIFYNPKHETTRKLLSAH 229

ABC_tran

pfam00005

ABC transporter; ABC transporters for a large family of proteins responsible for translocation ...

28-186

8.20e-38

ABC transporter; ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain pfam00664. These four domains may belong to a single polypeptide or belong in different polypeptide chains.

Pssm-ID: 394964 [Multi-domain] Cd Length: 150 Bit Score: 131.62 E-value: 8.20e-38

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   28 VNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKgtlIEGGMTVDGHDIMSLSNRALsdlrGAVVSMVFQEPRLalD 107
Cdd:pfam00005   1 LKNVSLTLNPGEILALVGPNGAGKSTLLKLIAGLLSP---TEGTILLDGQDLTDDERKSL----RKEIGYVFQDPQL--F 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  108 PVYTVGRQIEETiMRHEKVSRGLAAERALALFQKVRIPS-PERRLSNYPHEMSGGMLQRAMIAMALACNPKVLLADEPTT 186
Cdd:pfam00005  72 PRLTVRENLRLG-LLLKGLSKREKDARAEEALEKLGLGDlADRPVGERPGTLSGGQRQRVAIARALLTKPKLLLLDEPTA 150

tungstate_WtpC

NF040840

tungstate ABC transporter ATP-binding protein WtpC;

8-259

1.48e-28

tungstate ABC transporter ATP-binding protein WtpC;

Pssm-ID: 468779 [Multi-domain] Cd Length: 347 Bit Score: 112.86 E-value: 1.48e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSvtfrRGGKAVKaVNGVSLSVKPGEVVALLGESGSGKSVtmrsLLRLhpkgtlIEGGMTVDGHDIMsLSNRAL 87
Cdd:NF040840   1 MIRIENLS----KDWKEFK-LRDISLEVKEGEYFIILGPSGAGKTV----LLEL------IAGIWPPDSGKIY-LDGKDI 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  88 SDL----RGavVSMVFQEprLALDPVYTVGRQIEETiMRHEKVSRGLAAERALALFQKVRIpspERRLSNYPHEMSGGML 163
Cdd:NF040840  65 TNLppekRG--IAYVYQN--YMLFPHKTVFENIAFG-LKLRKVPKEEIERKVKEIMELLGI---SHLLHRKPRTLSGGEQ 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 164 QRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVG 243
Cdd:NF040840 137 QRVALARALIIEPKLLLLDEPLSALDVQTRDELIREMKRWHREFGFTAIHVTHNFEEALSLADRVGIMLNGRLSQVGDVR 216

                        250
                 ....*....|....*.
gi 523689182 244 DIIRNPRHPYTKGLLG 259
Cdd:NF040840 217 EVFRRPKNEFVARFVG 232

GguA

NF040905

sugar ABC transporter ATP-binding protein;

25-238

1.17e-21

sugar ABC transporter ATP-binding protein;

Pssm-ID: 468840 [Multi-domain] Cd Length: 500 Bit Score: 95.24 E-value: 1.17e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  25 VKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGTLiEGGMTVDGhDIMSLSNRALSDLRGAVVsmVFQEprL 104
Cdd:NF040905  14 VKALDDVNLSVREGEIHALCGENGAGKSTLMKVLSGVYPHGSY-EGEILFDG-EVCRFKDIRDSEALGIVI--IHQE--L 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 105 ALDPVYTvgrqIEETI-MRHEKVSRGL-----AAERALALFQKVRIP-SPERRLSNypheMSGGMLQRAMIAMALACNPK 177
Cdd:NF040905  88 ALIPYLS----IAENIfLGNERAKRGVidwneTNRRARELLAKVGLDeSPDTLVTD----IGVGKQQLVEIAKALSKDVK 159

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 523689182 178 VLLADEPTTALDATVQIQILLLIRELqREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVE 238
Cdd:NF040905 160 LLILDEPTAALNEEDSAALLDLLLEL-KAQGITSIIISHKLNEIRRVADSITVLRDGRTIE 219

AztA

NF040873

zinc ABC transporter ATP-binding protein AztA;

27-231

4.29e-17

zinc ABC transporter ATP-binding protein AztA;

Pssm-ID: 468810 [Multi-domain] Cd Length: 191 Bit Score: 78.04 E-value: 4.29e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  27 AVNGVSLSVKPGEVVALLGESGSGKSVTMRSLlrlhpKGTLIEGGMTVDGHdimslsnralsdlRGAVVSMVFQepRLAL 106
Cdd:NF040873   7 VLHGVDLTIPAGSLTAVVGPNGSGKSTLLKVL-----AGVLRPTSGTVRRA-------------GGARVAYVPQ--RSEV 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 107 DP--------VYTVGRQIEETIMRHEKVSRGLAAERALAlfqKVRIpspeRRLSNYP-HEMSGGMLQRAMIAMALACNPK 177
Cdd:NF040873  67 PDslpltvrdLVAMGRWARRGLWRRLTRDDRAAVDDALE---RVGL----ADLAGRQlGELSGGQRQRALLAQGLAQEAD 139

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 523689182 178 VLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEvADRIAVM 231
Cdd:NF040873 140 LLLLDEPTTGLDAESRERIIALLAEEHAR-GATVVVVTHDLELVRR-ADPCVLL 191

40850658_otr

NF000106

oxytetracycline efflux ABC transporter Otr(C) ATP-binding subunit;

25-245

1.87e-12

oxytetracycline efflux ABC transporter Otr(C) ATP-binding subunit;

Pssm-ID: 411078 [Multi-domain] Cd Length: 351 Bit Score: 67.07 E-value: 1.87e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  25 VKAVNGVSLSVKPGEVVALLGESGSGKSvtmRSLLRLHPKGTliEGGMTVDGHDIMSLSNRALSDLRGA--VVSMVFQEP 102
Cdd:NF000106  26 VKAVDGVDLDVREGTVLGVLGP*GAA**---RGALPAHV*GP--DAGRRPWRF*TWCANRRALRRTIG*hrPVR*GRRES 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 103 RLALDPVYTVGRQIEetimrhekVSRGLAAERALALFQKVRIPSPERRLSNyphEMSGGMLQRAMIAMALACNPKVLLAD 182
Cdd:NF000106 101 FSGRENLYMIGR*LD--------LSRKDARARADELLERFSLTEAAGRAAA---KYSGGMRRRLDLAASMIGRPAVLYLD 169

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 523689182 183 EPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDI 245
Cdd:NF000106 170 EPTTGLDPRTRNEVWDEVRSMVRD-GATVLLTTQYMEEAEQLAHELTVIDRGRVIADGKVDEL 231

GguA

NF040905

sugar ABC transporter ATP-binding protein;

26-239

4.73e-08

sugar ABC transporter ATP-binding protein;

Pssm-ID: 468840 [Multi-domain] Cd Length: 500 Bit Score: 54.03 E-value: 4.73e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  26 KAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRlHPKGTLIEGGMTVDGHDImslsnrALSDLRGAV------VSmvf 99
Cdd:NF040905 274 KVVDDVSLNVRRGEIVGIAGLMGAGRTELAMSVFG-RSYGRNISGTVFKDGKEV------DVSTVSDAIdaglayVT--- 343

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 100 qEPR--LALDPVYTVGRQIeeTIMRHEKVSRG----LAAERALA--LFQKVRI--PSPERRLSNypheMSGGMLQRAMIA 169
Cdd:NF040905 344 -EDRkgYGLNLIDDIKRNI--TLANLGKVSRRgvidENEEIKVAeeYRKKMNIktPSVFQKVGN----LSGGNQQKVVLS 416

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 523689182 170 MALACNPKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHD----IGvaaeVADRIAVMYAGRIVEE 239
Cdd:NF040905 417 KWLFTDPDVLILDEPTRGIDVGAKYEIYTIINELAAE-GKGVIVISSElpelLG----MCDRIYVMNEGRITGE 485

AAA

smart00382

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...

37-230

3.99e-07

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.

Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 48.91 E-value: 3.99e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182    37 PGEVVALLGESGSGKSVTMRSLLRLhpkgtlieggmtvdghdimslsnraLSDLRGAVVsmvfqepRLALDPVYTVGRQI 116
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARE-------------------------LGPPGGGVI-------YIDGEDILEEVLDQ 48

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   117 EETIMRHEKVSRGlaaeralalfqkvripsperrlsnyphemSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQI 196
Cdd:smart00382  49 LLLIIVGGKKASG-----------------------------SGELRLRLALALARKLKPDVLILDEITSLLDAEQEALL 99

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 523689182   197 LLLIR-----ELQREYGLSVIFVTHDIGVAAEVADRIAV 230
Cdd:smart00382 100 LLLEElrlllLLKSEKNLTVILTTNDEKDLGPALLRRRF 138

ABC2_perm_RbbA

NF033858

ribosome-associated ATPase/putative transporter RbbA;

27-236

8.56e-06

ribosome-associated ATPase/putative transporter RbbA;

Pssm-ID: 468210 [Multi-domain] Cd Length: 907 Bit Score: 47.43 E-value: 8.56e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  27 AVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGtliEG-----GMTVDGHDI--------MSLSNRALSDLrga 93
Cdd:NF033858 281 AVDHVSFRIRRGEIFGFLGSNGCGKSTTMKMLTGLLPAS---EGeawlfGQPVDAGDIatrrrvgyMSQAFSLYGEL--- 354

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  94 vvsmvfqeprlaldpvyTVgRQieeTIMRHEKVSRgLAAERAlalfqKVRIPSPERR--LSNYPHEMSG----GMLQRAM 167
Cdd:NF033858 355 -----------------TV-RQ---NLELHARLFH-LPAAEI-----AARVAEMLERfdLADVADALPDslplGIRQRLS 407

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 523689182 168 IAMALACNPKVLLADEPTT-----ALDATVQiqilLLIrELQREYGLSvIFV-THDIGvAAEVADRIAVMYAGRI 236
Cdd:NF033858 408 LAVAVIHKPELLILDEPTSgvdpvARDMFWR----LLI-ELSREDGVT-IFIsTHFMN-EAERCDRISLMHAGRV 475

ABC2_perm_RbbA

NF033858

ribosome-associated ATPase/putative transporter RbbA;

16-240

1.03e-03

ribosome-associated ATPase/putative transporter RbbA;

Pssm-ID: 468210 [Multi-domain] Cd Length: 907 Bit Score: 40.88 E-value: 1.03e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  16 VTFRRGgkAVKAVNGVSLSVKPGEVVALLGESGSGKSvtmrSLLrlhpkgTLI-------EGGMTVDGHDIMSLSNRAls 88
Cdd:NF033858   7 VSHRYG--KTVALDDVSLDIPAGCMVGLIGPDGVGKS----SLL------SLIagarkiqQGRVEVLGGDMADARHRR-- 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  89 dlrgAVVsmvfqePRLA---------LDPVYTVgrqiEETImrhEKVSR--GL-AAERAlalfqkVRI----------PS 146
Cdd:NF033858  73 ----AVC------PRIAympqglgknLYPTLSV----FENL---DFFGRlfGQdAAERR------RRIdellratglaPF 129

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 147 PER---RLSnyphemsGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREY-GLSVIfvthdigVA- 221
Cdd:NF033858 130 ADRpagKLS-------GGMKQKLGLCCALIHDPDLLILDEPTTGVDPLSRRQFWELIDRIRAERpGMSVL-------VAt 195

                        250       260
                 ....*....|....*....|....
gi 523689182 222 -----AEVADRIAVMYAGRIVEEG 240
Cdd:NF033858 196 aymeeAERFDWLVAMDAGRVLATG 219

Name

Accession

Description

Interval

E-value

DppD

COG0444

ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid ...

8-323

4.73e-177

ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];

Pssm-ID: 440213 [Multi-domain] Cd Length: 320 Bit Score: 492.26 E-value: 4.73e-177

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSVTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGTLIEGGMTVDGHDIMSLSNRAL 87
Cdd:COG0444    1 LLEVRNLKVYFPTRRGVVKAVDGVSFDVRRGETLGLVGESGSGKSTLARAILGLLPPPGITSGEILFDGEDLLKLSEKEL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  88 SDLRGAVVSMVFQEPRLALDPVYTVGRQIEETIMRHEKVSRGLAAERALALFQKVRIPSPERRLSNYPHEMSGGMLQRAM 167
Cdd:COG0444   81 RKIRGREIQMIFQDPMTSLNPVMTVGDQIAEPLRIHGGLSKAEARERAIELLERVGLPDPERRLDRYPHELSGGMRQRVM 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 168 IAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDIIR 247
Cdd:COG0444  161 IARALALEPKLLIADEPTTALDVTIQAQILNLLKDLQRELGLAILFITHDLGVVAEIADRVAVMYAGRIVEEGPVEELFE 240

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 523689182 248 NPRHPYTKGLLGARVELAEGRDRLVTIPGAPPDLAAMPPGCAFAPRCVQVSDLCQKQIPPLLPLSGGAGVACLFPD 323
Cdd:COG0444  241 NPRHPYTRALLSSIPRLDPDGRRLIPIPGEPPSLLNPPSGCRFHPRCPYAMDRCREEEPPLREVGPGHRVACHLYE 316

YejF

COG4172

ABC-type microcin C transport system, duplicated ATPase component YejF [Secondary metabolites ...

3-283

3.22e-132

ABC-type microcin C transport system, duplicated ATPase component YejF [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 443332 [Multi-domain] Cd Length: 533 Bit Score: 386.73 E-value: 3.22e-132

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   3 MQNDAMIDISNLSVTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGTLIEGG-MTVDGHDIMS 81
Cdd:COG4172    1 MMSMPLLSVEDLSVAFGQGGGTVEAVKGVSFDIAAGETLALVGESGSGKSVTALSILRLLPDPAAHPSGsILFDGQDLLG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  82 LSNRALSDLRGAVVSMVFQEPRLALDPVYTVGRQIEETIMRHEKVSRGLAAERALALFQKVRIPSPERRLSNYPHEMSGG 161
Cdd:COG4172   81 LSERELRRIRGNRIAMIFQEPMTSLNPLHTIGKQIAEVLRLHRGLSGAAARARALELLERVGIPDPERRLDAYPHQLSGG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 162 MLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGL 241
Cdd:COG4172  161 QRQRVMIAMALANEPDLLIADEPTTALDVTVQAQILDLLKDLQRELGMALLLITHDLGVVRRFADRVAVMRQGEIVEQGP 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 523689182 242 VGDIIRNPRHPYTKGLLGARVElaegRDRLVTIPGAPPDLAA 283
Cdd:COG4172  241 TAELFAAPQHPYTRKLLAAEPR----GDPRPVPPDAPPLLEA 278

oppD

PRK09473

oligopeptide transporter ATP-binding component; Provisional

4-322

5.60e-112

oligopeptide transporter ATP-binding component; Provisional

Pssm-ID: 181888 [Multi-domain] Cd Length: 330 Bit Score: 327.84 E-value: 5.60e-112

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   4 QNDAMIDISNLSVTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGTLIEGGMTVDGHDIMSLS 83
Cdd:PRK09473   8 QADALLDVKDLRVTFSTPDGDVTAVNDLNFSLRAGETLGIVGESGSGKSQTAFALMGLLAANGRIGGSATFNGREILNLP 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  84 NRALSDLRGAVVSMVFQEPRLALDPVYTVGRQIEETIMRHEKVSRGLAAERALALFQKVRIPSPERRLSNYPHEMSGGML 163
Cdd:PRK09473  88 EKELNKLRAEQISMIFQDPMTSLNPYMRVGEQLMEVLMLHKGMSKAEAFEESVRMLDAVKMPEARKRMKMYPHEFSGGMR 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 164 QRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVG 243
Cdd:PRK09473 168 QRVMIAMALLCRPKLLIADEPTTALDVTVQAQIMTLLNELKREFNTAIIMITHDLGVVAGICDKVLVMYAGRTMEYGNAR 247

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 523689182 244 DIIRNPRHPYTKGLLGARVELAEGRDRLVTIPGAPPDLAAMPPGCAFAPRCVQVSDLCQkQIPPLLPLSGGAGVACLFP 322
Cdd:PRK09473 248 DVFYQPSHPYSIGLLNAVPRLDAEGESLLTIPGNPPNLLRLPKGCPFQPRCPHAMEICS-SAPPLEEFGPGRLRACFKP 325

ABC_NikE_OppD_transporters

cd03257

ATP-binding cassette domain of nickel/oligopeptides specific transporters; The ABC transporter ...

8-240

1.23e-111

Pssm-ID: 213224 [Multi-domain] Cd Length: 228 Bit Score: 323.30 E-value: 1.23e-111

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSVTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKgtlIEGGMTVDGHDIMSLSNRAL 87
Cdd:cd03257    1 LLEVKNLSVSFPTGGGSVKALDDVSFSIKKGETLGLVGESGSGKSTLARAILGLLKP---TSGSIIFDGKDLLKLSRRLR 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  88 SdLRGAVVSMVFQEPRLALDPVYTVGRQIEETIMRHEKVSRGLAAERALALfQKVRIPSPERRLSNYPHEMSGGMLQRAM 167
Cdd:cd03257   78 K-IRRKEIQMVFQDPMSSLNPRMTIGEQIAEPLRIHGKLSKKEARKEAVLL-LLVGVGLPEEVLNRYPHELSGGQRQRVA 155

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 523689182 168 IAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEG 240
Cdd:cd03257  156 IARALALNPKLLIADEPTSALDVSVQAQILDLLKKLQEELGLTLLFITHDLGVVAKIADRVAVMYAGKIVEEG 228

AppF

COG4608

ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; ...

3-323

3.34e-104

ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism];

Pssm-ID: 443658 [Multi-domain] Cd Length: 329 Bit Score: 307.81 E-value: 3.34e-104

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   3 MQNDAMIDISNLSVTF-------RRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKgTliEGGMTVD 75
Cdd:COG4608    2 AMAEPLLEVRDLKKHFpvrgglfGRTVGVVKAVDGVSFDIRRGETLGLVGESGCGKSTLGRLLLRLEEP-T--SGEILFD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  76 GHDIMSLSNRALSDLRgAVVSMVFQEPRLALDPVYTVGRQIEETIMRHEKVSRGLAAERALALFQKVRIPsPERrLSNYP 155
Cdd:COG4608   79 GQDITGLSGRELRPLR-RRMQMVFQDPYASLNPRMTVGDIIAEPLRIHGLASKAERRERVAELLELVGLR-PEH-ADRYP 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 156 HEMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGR 235
Cdd:COG4608  156 HEFSGGQRQRIGIARALALNPKLIVCDEPVSALDVSIQAQVLNLLEDLQDELGLTYLFISHDLSVVRHISDRVAVMYLGK 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 236 IVEEGLVGDIIRNPRHPYTKGLLGA--RVELAEGRDRLVtIPGAPPDLAAMPPGCAFAPRCVQVSDLCQKQIPPLLPLSG 313
Cdd:COG4608  236 IVEIAPRDELYARPLHPYTQALLSAvpVPDPERRRERIV-LEGDVPSPLNPPSGCRFHTRCPYAQDRCATEEPPLREVGP 314

                        330
                 ....*....|
gi 523689182 314 GAGVACLFPD 323
Cdd:COG4608  315 GHQVACHLAE 324

dppD

PRK11022

dipeptide transporter ATP-binding subunit; Provisional

7-322

8.24e-104

dipeptide transporter ATP-binding subunit; Provisional

Pssm-ID: 182906 [Multi-domain] Cd Length: 326 Bit Score: 307.05 E-value: 8.24e-104

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   7 AMIDISNLSVTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRL--HPkGTLIEGGMTVDGHDIMSLSN 84
Cdd:PRK11022   2 ALLNVDKLSVHFGDESAPFRAVDRISYSVKQGEVVGIVGESGSGKSVSSLAIMGLidYP-GRVMAEKLEFNGQDLQRISE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  85 RALSDLRGAVVSMVFQEPRLALDPVYTVGRQIEETIMRHEKVSRGLAAERALALFQKVRIPSPERRLSNYPHEMSGGMLQ 164
Cdd:PRK11022  81 KERRNLVGAEVAMIFQDPMTSLNPCYTVGFQIMEAIKVHQGGNKKTRRQRAIDLLNQVGIPDPASRLDVYPHQLSGGMSQ 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 165 RAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGD 244
Cdd:PRK11022 161 RVMIAMAIACRPKLLIADEPTTALDVTIQAQIIELLLELQQKENMALVLITHDLALVAEAAHKIIVMYAGQVVETGKAHD 240

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 523689182 245 IIRNPRHPYTKGLLGARVELAEGRDRLVTIPGAPPDLAAMPPGCAFAPRCVQVSDLCQKQIPPLLPLsGGAGVACLFP 322
Cdd:PRK11022 241 IFRAPRHPYTQALLRALPEFAQDKARLASLPGVVPGKYDRPNGCLLNPRCPYATDRCRAEEPALNML-AGRQSKCHYP 317

GsiA

COG1123

ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain ...

6-260

4.37e-97

ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain [Posttranslational modification, protein turnover, chaperones];

Pssm-ID: 440740 [Multi-domain] Cd Length: 514 Bit Score: 296.04 E-value: 4.37e-97

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   6 DAMIDISNLSVTFR-RGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPkgtLIEGGMTVDGHDIMSLSN 84
Cdd:COG1123  258 EPLLEVRNLSKRYPvRGKGGVRAVDDVSLTLRRGETLGLVGESGSGKSTLARLLLGLLR---PTSGSILFDGKDLTKLSR 334

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  85 RALSDLRGAVvSMVFQEPRLALDPVYTVGRQIEETIMRHEKVSRGLAAERALALFQKVRIPspERRLSNYPHEMSGGMLQ 164
Cdd:COG1123  335 RSLRELRRRV-QMVFQDPYSSLNPRMTVGDIIAEPLRLHGLLSRAERRERVAELLERVGLP--PDLADRYPHELSGGQRQ 411

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 165 RAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGD 244
Cdd:COG1123  412 RVAIARALALEPKLLILDEPTSALDVSVQAQILNLLRDLQRELGLTYLFISHDLAVVRYIADRVAVMYDGRIVEDGPTEE 491

                        250
                 ....*....|....*.
gi 523689182 245 IIRNPRHPYTKGLLGA 260
Cdd:COG1123  492 VFANPQHPYTRALLAA 507

GsiA

COG1123

ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain ...

6-281

2.02e-94

ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain [Posttranslational modification, protein turnover, chaperones];

Pssm-ID: 440740 [Multi-domain] Cd Length: 514 Bit Score: 289.11 E-value: 2.02e-94

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   6 DAMIDISNLSVTFRRGgkAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGTLIEGGMTVDGHDIMSLSNR 85
Cdd:COG1123    2 TPLLEVRDLSVRYPGG--DVPAVDGVSLTIAPGETVALVGESGSGKSTLALALMGLLPHGGRISGEVLLDGRDLLELSEA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  86 alsdLRGAVVSMVFQEPRLALDPVyTVGRQIEETImRHEKVSRGLAAERALALFQKVRIpspERRLSNYPHEMSGGMLQR 165
Cdd:COG1123   80 ----LRGRRIGMVFQDPMTQLNPV-TVGDQIAEAL-ENLGLSRAEARARVLELLEAVGL---ERRLDRYPHQLSGGQRQR 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 166 AMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDI 245
Cdd:COG1123  151 VAIAMALALDPDLLIADEPTTALDVTTQAEILDLLRELQRERGTTVLLITHDLGVVAEIADRVVVMDDGRIVEDGPPEEI 230

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 523689182 246 IRNPRhpytkgLLGARVELAEGRDRLVTIPGAPPDL 281
Cdd:COG1123  231 LAAPQ------ALAAVPRLGAARGRAAPAAAAAEPL 260

DppF

COG1124

ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid ...

8-260

6.47e-87

ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];

Pssm-ID: 440741 [Multi-domain] Cd Length: 248 Bit Score: 260.89 E-value: 6.47e-87

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSVTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGTlieGGMTVDGHDImslSNRAL 87
Cdd:COG1124    1 MLEVRNLSVSYGQGGRRVPVLKDVSLEVAPGESFGLVGESGSGKSTLLRALAGLERPWS---GEVTFDGRPV---TRRRR 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  88 SDLRGAVvSMVFQEPRLALDPVYTVGRQIEETIMRHEkvsRGLAAERALALFQKVRIPspERRLSNYPHEMSGGMLQRAM 167
Cdd:COG1124   75 KAFRRRV-QMVFQDPYASLHPRHTVDRILAEPLRIHG---LPDREERIAELLEQVGLP--PSFLDRYPHQLSGGQRQRVA 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 168 IAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDIIR 247
Cdd:COG1124  149 IARALILEPELLLLDEPTSALDVSVQAEILNLLKDLREERGLTYLFVSHDLAVVAHLCDRVAVMQNGRIVEELTVADLLA 228

                        250
                 ....*....|...
gi 523689182 248 NPRHPYTKGLLGA 260
Cdd:COG1124  229 GPKHPYTRELLAA 241

SapD

COG4170

ABC-type antimicrobial peptide export system, ATPase component SapD [Defense mechanisms];

7-322

4.32e-82

ABC-type antimicrobial peptide export system, ATPase component SapD [Defense mechanisms];

Pssm-ID: 443330 [Multi-domain] Cd Length: 331 Bit Score: 251.75 E-value: 4.32e-82

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   7 AMIDISNLSVTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGTLIEGG-MTVDGHDIMSLSNR 85
Cdd:COG4170    2 PLLDIRNLTIEIDTPQGRVKAVDRVSLTLNEGEIRGLVGESGSGKSLIAKAICGITKDNWHVTADrFRWNGIDLLKLSPR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  86 ALSDLRGAVVSMVFQEPRLALDPVYTVGRQIEETIMRHE-KVS----RGLAAERALALFQKVRIPSPERRLSNYPHEMSG 160
Cdd:COG4170   82 ERRKIIGREIAMIFQEPSSCLDPSAKIGDQLIEAIPSWTfKGKwwqrFKWRKKRAIELLHRVGIKDHKDIMNSYPHELTE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 161 GMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEG 240
Cdd:COG4170  162 GECQKVMIAMAIANQPRLLIADEPTNAMESTTQAQIFRLLARLNQLQGTSILLISHDLESISQWADTITVLYCGQTVESG 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 241 LVGDIIRNPRHPYTKGLLGA----RVELAEgRDRLVTIPGAPPDLAAMPPGCAFAPRCVQVSDLCQKQiPPLLPLSGGAg 316
Cdd:COG4170  242 PTEQILKSPHHPYTKALLRSmpdfRQPLPH-KSRLNTLPGSIPPLQHLPIGCRLGPRCPYAQKKCVET-PRLRKIKGHE- 318


                 ....*.
gi 523689182 317 VACLFP 322
Cdd:COG4170  319 FACHFP 324

nickel_nikD

TIGR02770

nickel import ATP-binding protein NikD; This family represents the NikD subunit of a ...

27-261

2.03e-81

Pssm-ID: 131817 [Multi-domain] Cd Length: 230 Bit Score: 246.51 E-value: 2.03e-81

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   27 AVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGTLI-EGGMTVDGHDIMSLSnralsdLRGAVVSMVFQEPRLA 105
Cdd:TIGR02770   1 LVQDLNLSLKRGEVLALVGESGSGKSLTCLAILGLLPPGLTQtSGEILLDGRPLLPLS------IRGRHIATIMQNPRTA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  106 LDPVYTVGRQIEETIMRHEKVSRGlAAERALALFQKVRIPSPERRLSNYPHEMSGGMLQRAMIAMALACNPKVLLADEPT 185
Cdd:TIGR02770  75 FNPLFTMGNHAIETLRSLGKLSKQ-ARALILEALEAVGLPDPEEVLKKYPFQLSGGMLQRVMIALALLLEPPFLIADEPT 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 523689182  186 TALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDIIRNPRHPYTKGLLGAR 261
Cdd:TIGR02770 154 TDLDVVNQARVLKLLRELRQLFGTGILLITHDLGVVARIADEVAVMDDGRIVERGTVKEIFYNPKHETTRKLLSAH 229

PRK10261

glutathione transporter ATP-binding protein; Provisional

3-266

1.98e-80

glutathione transporter ATP-binding protein; Provisional

Pssm-ID: 182342 [Multi-domain] Cd Length: 623 Bit Score: 256.32 E-value: 1.98e-80

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   3 MQNDAMIDISNLSVTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRL--HPKGTLIEGGMTVDGH--- 77
Cdd:PRK10261   7 LDARDVLAVENLNIAFMQEQQKIAAVRNLSFSLQRGETLAIVGESGSGKSVTALALMRLleQAGGLVQCDKMLLRRRsrq 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  78 --DIMSLSNRALSDLRGAVVSMVFQEPRLALDPVYTVGRQIEETIMRHEKVSRGLAAERALALFQKVRIPSPERRLSNYP 155
Cdd:PRK10261  87 viELSEQSAAQMRHVRGADMAMIFQEPMTSLNPVFTVGEQIAESIRLHQGASREEAMVEAKRMLDQVRIPEAQTILSRYP 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 156 HEMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGR 235
Cdd:PRK10261 167 HQLSGGMRQRVMIAMALSCRPAVLIADEPTTALDVTIQAQILQLIKVLQKEMSMGVIFITHDMGVVAEIADRVLVMYQGE 246

                        250       260       270
                 ....*....|....*....|....*....|.
gi 523689182 236 IVEEGLVGDIIRNPRHPYTKGLLGARVELAE 266
Cdd:PRK10261 247 AVETGSVEQIFHAPQHPYTRALLAAVPQLGA 277

YejF

COG4172

ABC-type microcin C transport system, duplicated ATPase component YejF [Secondary metabolites ...

9-260

2.55e-78

ABC-type microcin C transport system, duplicated ATPase component YejF [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 443332 [Multi-domain] Cd Length: 533 Bit Score: 248.06 E-value: 2.55e-78

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTF-------RRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKgtliEGGMTVDGHDIMS 81
Cdd:COG4172  276 LEARDLKVWFpikrglfRRTVGHVKAVDGVSLTLRRGETLGLVGESGSGKSTLGLALLRLIPS----EGEIRFDGQDLDG 351

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  82 LSNRALSDLRgAVVSMVFQEPRLALDPVYTVGRQIEETIMRHE-KVSRGLAAERALALFQKVRIPsPERRlSNYPHEMSG 160
Cdd:COG4172  352 LSRRALRPLR-RRMQVVFQDPFGSLSPRMTVGQIIAEGLRVHGpGLSAAERRARVAEALEEVGLD-PAAR-HRYPHEFSG 428

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 161 GMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEG 240
Cdd:COG4172  429 GQRQRIAIARALILEPKLLVLDEPTSALDVSVQAQILDLLRDLQREHGLAYLFISHDLAVVRALAHRVMVMKDGKVVEQG 508

                        250       260
                 ....*....|....*....|
gi 523689182 241 LVGDIIRNPRHPYTKGLLGA 260
Cdd:COG4172  509 PTEQVFDAPQHPYTRALLAA 528

dppF

PRK11308

dipeptide transporter ATP-binding subunit; Provisional

20-319

5.91e-78

dipeptide transporter ATP-binding subunit; Provisional

Pssm-ID: 236898 [Multi-domain] Cd Length: 327 Bit Score: 241.02 E-value: 5.91e-78

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  20 RGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLlrlhpkgTLIE----GGMTVDGHDIMSLSNRALSDLRGAVv 95
Cdd:PRK11308  23 KPERLVKALDGVSFTLERGKTLAVVGESGCGKSTLARLL-------TMIEtptgGELYYQGQDLLKADPEAQKLLRQKI- 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  96 SMVFQEPRLALDPVYTVGRQIEETIMRHEKVSRGLAAERALALFQKVRIpSPERrLSNYPHEMSGGMLQRAMIAMALACN 175
Cdd:PRK11308  95 QIVFQNPYGSLNPRKKVGQILEEPLLINTSLSAAERREKALAMMAKVGL-RPEH-YDRYPHMFSGGQRQRIAIARALMLD 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 176 PKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDIIRNPRHPYTK 255
Cdd:PRK11308 173 PDVVVADEPVSALDVSVQAQVLNLMMDLQQELGLSYVFISHDLSVVEHIADEVMVMYLGRCVEKGTKEQIFNNPRHPYTQ 252

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 523689182 256 GLLGARVELAEGRDRL-VTIPGAPPDLAAMPPGCAFAPRCVQVSDLCQKQIPPLLPLsGGAGVAC 319
Cdd:PRK11308 253 ALLSATPRLNPDDRRErIKLTGELPSPLNPPPGCAFNARCPRAFGRCRQEQPQLRDY-DGRLVAC 316

PRK15134

microcin C ABC transporter ATP-binding protein YejF; Provisional

1-260

7.13e-77

microcin C ABC transporter ATP-binding protein YejF; Provisional

Pssm-ID: 237917 [Multi-domain] Cd Length: 529 Bit Score: 244.61 E-value: 7.13e-77

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   1 MTMqndAMIDISNLSVTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGTLI--EGGMTVDGHD 78
Cdd:PRK15134   1 MTQ---PLLAIENLSVAFRQQQTVRTVVNDVSLQIEAGETLALVGESGSGKSVTALSILRLLPSPPVVypSGDIRFHGES 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  79 IMSLSNRALSDLRGAVVSMVFQEPRLALDPVYTVGRQIEETIMRHEKVSRGLAAERALALFQKVRIPSPERRLSNYPHEM 158
Cdd:PRK15134  78 LLHASEQTLRGVRGNKIAMIFQEPMVSLNPLHTLEKQLYEVLSLHRGMRREAARGEILNCLDRVGIRQAAKRLTDYPHQL 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 159 SGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVE 238
Cdd:PRK15134 158 SGGERQRVMIAMALLTRPELLIADEPTTALDVSVQAQILQLLRELQQELNMGLLFITHNLSIVRKLADRVAVMQNGRCVE 237

                        250       260
                 ....*....|....*....|..
gi 523689182 239 EGLVGDIIRNPRHPYTKGLLGA 260
Cdd:PRK15134 238 QNRAATLFSAPTHPYTQKLLNS 259

PhnK

COG4107

ABC-type phosphonate transport system, ATPase component PhnK [Inorganic ion transport and ...

1-254

2.14e-70

ABC-type phosphonate transport system, ATPase component PhnK [Inorganic ion transport and metabolism];

Pssm-ID: 443283 [Multi-domain] Cd Length: 262 Bit Score: 219.30 E-value: 2.14e-70

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   1 MTMQNDAMIDISNLSVTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSL-LRLHP-KGTLIEGGMTVDGHD 78
Cdd:COG4107    1 MTNEEQPLLSVRGLSKRYGPGCGTVVACRDVSFDLYPGEVLGIVGESGSGKSTLLKCLyFDLAPtSGSVYYRDRDGGPRD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  79 IMSLSNRALSDLRGAVVSMVFQEPRLALDPVYTVGRQIEETIM----RHEKVSRglaaERALALFQKVRIPSpeRRLSNY 154
Cdd:COG4107   81 LFALSEAERRRLRRTDWGMVYQNPRDGLRMDVSAGGNIAERLMaageRHYGDIR----ARALEWLERVEIPL--ERIDDL 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 155 PHEMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAG 234
Cdd:COG4107  155 PRTFSGGMQQRVQIARALVTNPRLLFLDEPTTGLDVSVQARLLDLIRRLQRELGLSMIVVTHDLGVIRLLADRTMVMKNG 234

                        250       260
                 ....*....|....*....|
gi 523689182 235 RIVEEGLVGDIIRNPRHPYT 254
Cdd:COG4107  235 RVVESGLTDQVLEDPQHPYT 254

PRK15093

peptide ABC transporter ATP-binding protein SapD;

8-322

6.88e-68

peptide ABC transporter ATP-binding protein SapD;

Pssm-ID: 185049 [Multi-domain] Cd Length: 330 Bit Score: 215.44 E-value: 6.88e-68

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSVTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGTLIEGG-MTVDGHDIMSLSNRA 86
Cdd:PRK15093   3 LLDIRNLTIEFKTSDGWVKAVDRVSMTLTEGEIRGLVGESGSGKSLIAKAICGVTKDNWRVTADrMRFDDIDLLRLSPRE 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  87 LSDLRGAVVSMVFQEPRLALDPVYTVGRQIEETIMRHEKVSR-----GLAAERALALFQKVRIPSPERRLSNYPHEMSGG 161
Cdd:PRK15093  83 RRKLVGHNVSMIFQEPQSCLDPSERVGRQLMQNIPGWTYKGRwwqrfGWRKRRAIELLHRVGIKDHKDAMRSFPYELTEG 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 162 MLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGL 241
Cdd:PRK15093 163 ECQKVMIAIALANQPRLLIADEPTNAMEPTTQAQIFRLLTRLNQNNNTTILLISHDLQMLSQWADKINVLYCGQTVETAP 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 242 VGDIIRNPRHPYTKGLLGARVELAEG---RDRLVTIPGAPPDLAAMPPGCAFAPRCVQVSDLCQkQIPPLLPLSGGAgVA 318
Cdd:PRK15093 243 SKELVTTPHHPYTQALIRAIPDFGSAmphKSRLNTLPGAIPLLEHLPIGCRLGPRCPYAQRECI-ETPRLTGAKNHL-YA 320


                 ....
gi 523689182 319 CLFP 322
Cdd:PRK15093 321 CHFP 324

PRK15079

oligopeptide ABC transporter ATP-binding protein OppF; Provisional

1-320

2.45e-67

oligopeptide ABC transporter ATP-binding protein OppF; Provisional

Pssm-ID: 185037 [Multi-domain] Cd Length: 331 Bit Score: 213.80 E-value: 2.45e-67

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   1 MTMQNDAMIDISNLSVTFR-RGGKA--------VKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKgtlIEGG 71
Cdd:PRK15079   1 VTEGKKVLLEVADLKVHFDiKDGKQwfwqppktLKAVDGVTLRLYEGETLGVVGESGCGKSTFARAIIGLVKA---TDGE 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  72 MTVDGHDIMSLSNRALSDLRGAVvSMVFQEPRLALDPVYTVGRQIEETI-MRHEKVSRGLAAERALALFQKVRI-PSPER 149
Cdd:PRK15079  78 VAWLGKDLLGMKDDEWRAVRSDI-QMIFQDPLASLNPRMTIGEIIAEPLrTYHPKLSRQEVKDRVKAMMLKVGLlPNLIN 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 150 RlsnYPHEMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIA 229
Cdd:PRK15079 157 R---YPHEFSGGQCQRIGIARALILEPKLIICDEPVSALDVSIQAQVVNLLQQLQREMGLSLIFIAHDLAVVKHISDRVL 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 230 VMYAGRIVEEGLVGDIIRNPRHPYTKGLLGA------------RVELAEGRdrlVTIPGAPPDlaamppGCAFAPRCVQV 297
Cdd:PRK15079 234 VMYLGHAVELGTYDEVYHNPLHPYTKALMSAvpipdpdlernkTIQLLEGE---LPSPINPPS------GCVFRTRCPIA 304

                        330       340
                 ....*....|....*....|...
gi 523689182 298 SDLCQKQiPPLLPLSGGAGVACL 320
Cdd:PRK15079 305 GPECAKT-RPVLEGSFRHAVSCL 326

AbcC

COG1135

ABC-type methionine transport system, ATPase component [Amino acid transport and metabolism];

8-274

5.26e-67

ABC-type methionine transport system, ATPase component [Amino acid transport and metabolism];

Pssm-ID: 440750 [Multi-domain] Cd Length: 339 Bit Score: 213.40 E-value: 5.26e-67

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSVTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSvtmrSLLRL-----HPkgTliEGGMTVDGHDIMSL 82
Cdd:COG1135    1 MIELENLSKTFPTKGGPVTALDDVSLTIEKGEIFGIIGYSGAGKS----TLIRCinlleRP--T--SGSVLVDGVDLTAL 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  83 SNRALSDLRGAVvSMVFQEPRLaLDpvytvGRQIEETI---MRHEKVSRGLAAERALALFQKVRIpspERRLSNYPHEMS 159
Cdd:COG1135   73 SERELRAARRKI-GMIFQHFNL-LS-----SRTVAENValpLEIAGVPKAEIRKRVAELLELVGL---SDKADAYPSQLS 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 160 GGMLQRAMIAMALACNPKVLLADEPTTALD-ATVQiQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVE 238
Cdd:COG1135  143 GGQKQRVGIARALANNPKVLLCDEATSALDpETTR-SILDLLKDINRELGLTIVLITHEMDVVRRICDRVAVLENGRIVE 221

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 523689182 239 EGLVGDIIRNPRHPYTKGLLG------------ARVELAEGRDRLVTI 274
Cdd:COG1135  222 QGPVLDVFANPQSELTRRFLPtvlndelpeellARLREAAGGGRLVRL 269

nikD

PRK10418

nickel transporter ATP-binding protein NikD; Provisional

9-264

4.97e-64

nickel transporter ATP-binding protein NikD; Provisional

Pssm-ID: 236688 [Multi-domain] Cd Length: 254 Bit Score: 203.01 E-value: 4.97e-64

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTfrrggKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKG-TLIEGGMTVDGHDImslsnrAL 87
Cdd:PRK10418   5 IELRNIALQ-----AAQPLVHGVSLTLQRGRVLALVGGSGSGKSLTCAAALGILPAGvRQTAGRVLLDGKPV------AP 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  88 SDLRGAVVSMVFQEPRLALDPVYTVGRQIEETIMrhekvSRGLAAERA--LALFQKVRIPSPERRLSNYPHEMSGGMLQR 165
Cdd:PRK10418  74 CALRGRKIATIMQNPRSAFNPLHTMHTHARETCL-----ALGKPADDAtlTAALEAVGLENAARVLKLYPFEMSGGMLQR 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 166 AMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDI 245
Cdd:PRK10418 149 MMIALALLCEAPFIIADEPTTDLDVVAQARILDLLESIVQKRALGMLLVTHDMGVVARLADDVAVMSHGRIVEQGDVETL 228

                        250
                 ....*....|....*....
gi 523689182 246 IRNPRHPYTKGLLGARVEL 264
Cdd:PRK10418 229 FNAPKHAVTRSLVSAHLAL 247

ABC_MJ0796_LolCDE_FtsE

cd03255

ATP-binding cassette domain of the transporters involved in export of lipoprotein and ...

9-236

1.18e-63

ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and Cell division ATP-binding protein FtsE; This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. The FtsEX complex resembles an ABC transporter, where FtsE is the ATPase and the membrane subunit FtsX resembles a permease subunit. But rather than transporting any substrate, the complex acts in cell division by undergoing conformational changes that alter the activity of cell wall hydrolases located outside the plasma membrane. The complex is widely conserved in bacteria, but also extremely divergent in sequence between different lineages. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.

Pssm-ID: 213222 [Multi-domain] Cd Length: 218 Bit Score: 200.79 E-value: 1.18e-63

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSvTMRSLLrlhpkGTLI---EGGMTVDGHDIMSLSNR 85
Cdd:cd03255    1 IELKNLSKTYGGGGEKVQALKGVSLSIEKGEFVAIVGPSGSGKS-TLLNIL-----GGLDrptSGEVRVDGTDISKLSEK 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  86 ALSDLRGAVVSMVFQEPRLAldPVYTVGRQIEeTIMRHEKVSRGLAAERALALFQKVRIpspERRLSNYPHEMSGGMLQR 165
Cdd:cd03255   75 ELAAFRRRHIGFVFQSFNLL--PDLTALENVE-LPLLLAGVPKKERRERAEELLERVGL---GDRLNHYPSELSGGQQQR 148

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 523689182 166 AMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEvADRIAVMYAGRI 236
Cdd:cd03255  149 VAIARALANDPKIILADEPTGNLDSETGKEVMELLRELNKEAGTTIVVVTHDPELAEY-ADRIIELRDGKI 218

LolD

COG1136

ABC-type lipoprotein export system, ATPase component [Cell wall/membrane/envelope biogenesis];

6-239

8.56e-62

ABC-type lipoprotein export system, ATPase component [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 440751 [Multi-domain] Cd Length: 227 Bit Score: 196.03 E-value: 8.56e-62

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   6 DAMIDISNLSVTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSvTMRSLLrlhpkGTLI---EGGMTVDGHDIMSL 82
Cdd:COG1136    2 SPLLELRNLTKSYGTGEGEVTALRGVSLSIEAGEFVAIVGPSGSGKS-TLLNIL-----GGLDrptSGEVLIDGQDISSL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  83 SNRALSDLRGAVVSMVFQEPRLalDPVYTVGRQIEeTIMRHEKVSRGLAAERALALFQKVRIpspERRLSNYPHEMSGGM 162
Cdd:COG1136   76 SERELARLRRRHIGFVFQFFNL--LPELTALENVA-LPLLLAGVSRKERRERARELLERVGL---GDRLDHRPSQLSGGQ 149

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 523689182 163 LQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEvADRIAVMYAGRIVEE 239
Cdd:COG1136  150 QQRVAIARALVNRPKLILADEPTGNLDSKTGEEVLELLRELNRELGTTIVMVTHDPELAAR-ADRVIRLRDGRIVSD 225

ABC_MetN_methionine_transporter

cd03258

ATP-binding cassette domain of methionine transporter; MetN (also known as YusC) is an ...

8-250

4.07e-59

ATP-binding cassette domain of methionine transporter; MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213225 [Multi-domain] Cd Length: 233 Bit Score: 189.71 E-value: 4.07e-59

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSVTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRsLLRLHPKGTliEGGMTVDGHDIMSLSNRAL 87
Cdd:cd03258    1 MIELKNVSKVFGDTGGKVTALKDVSLSVPKGEIFGIIGRSGAGKSTLIR-CINGLERPT--SGSVLVDGTDLTLLSGKEL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  88 SDLRgAVVSMVFQEPRLaLDpvytvGRQIEETI---MRHEKVSRGLAAERALALFQKVRIpspERRLSNYPHEMSGGMLQ 164
Cdd:cd03258   78 RKAR-RRIGMIFQHFNL-LS-----SRTVFENValpLEIAGVPKAEIEERVLELLELVGL---EDKADAYPAQLSGGQKQ 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 165 RAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGD 244
Cdd:cd03258  148 RVGIARALANNPKVLLCDEATSALDPETTQSILALLRDINRELGLTIVLITHEMEVVKRICDRVAVMEKGEVVEEGTVEE 227


                 ....*.
gi 523689182 245 IIRNPR 250
Cdd:cd03258  228 VFANPQ 233

GlnQ

COG1126

ABC-type polar amino acid transport system, ATPase component [Amino acid transport and ...

8-255

2.12e-58

ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism];

Pssm-ID: 440743 [Multi-domain] Cd Length: 239 Bit Score: 187.89 E-value: 2.12e-58

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSVTFrrGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPkgtlIEGG-MTVDGHDImSLSNRA 86
Cdd:COG1126    1 MIEIENLHKSF--GDLEV--LKGISLDVEKGEVVVIIGPSGSGKSTLLRCINLLEE----PDSGtITVDGEDL-TDSKKD 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  87 LSDLRgAVVSMVFQepRLALDPVYTVGRQIEETIMRHEKVSRGLAAERALALFQKVRIPSperRLSNYPHEMSGGMLQRA 166
Cdd:COG1126   72 INKLR-RKVGMVFQ--QFNLFPHLTVLENVTLAPIKVKKMSKAEAEERAMELLERVGLAD---KADAYPAQLSGGQQQRV 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 167 MIAMALACNPKVLLADEPTTALD-ATVQiQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDI 245
Cdd:COG1126  146 AIARALAMEPKVMLFDEPTSALDpELVG-EVLDVMRDLAKE-GMTMVVVTHEMGFAREVADRVVFMDGGRIVEEGPPEEF 223

                        250
                 ....*....|
gi 523689182 246 IRNPRHPYTK 255
Cdd:COG1126  224 FENPQHERTR 233

MlaF

COG1127

ATPase subunit MlaF of the ABC-type intermembrane phospholipid transporter Mla [Cell wall ...

4-255

3.67e-57

ATPase subunit MlaF of the ABC-type intermembrane phospholipid transporter Mla [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 440744 [Multi-domain] Cd Length: 241 Bit Score: 184.80 E-value: 3.67e-57

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   4 QNDAMIDISNLsvTFRRGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHP--KGTlieggMTVDGHDIMS 81
Cdd:COG1127    1 MSEPMIEVRNL--TKSFGDRVV--LDGVSLDVPRGEILAIIGGSGSGKSVLLKLIIGLLRpdSGE-----ILVDGQDITG 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  82 LSNRALSDLRgAVVSMVFQEPRL--ALdpvyTVgrqiEETIM----RHEKVSRGLAAERALALFQKVRIPSPERRlsnYP 155
Cdd:COG1127   72 LSEKELYELR-RRIGMLFQGGALfdSL----TV----FENVAfplrEHTDLSEAEIRELVLEKLELVGLPGAADK---MP 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 156 HEMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGR 235
Cdd:COG1127  140 SELSGGMRKRVALARALALDPEILLYDEPTAGLDPITSAVIDELIRELRDELGLTSVVVTHDLDSAFAIADRVAVLADGK 219

                        250       260
                 ....*....|....*....|
gi 523689182 236 IVEEGLVGDiIRNPRHPYTK 255
Cdd:COG1127  220 IIAEGTPEE-LLASDDPWVR 238

PotA

COG3842

ABC-type Fe3+/spermidine/putrescine transport systems, ATPase component [Amino acid transport ...

1-287

5.25e-55

ABC-type Fe3+/spermidine/putrescine transport systems, ATPase component [Amino acid transport and metabolism];

Pssm-ID: 443052 [Multi-domain] Cd Length: 353 Bit Score: 182.61 E-value: 5.25e-55

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   1 MTMqndAMIDISNLSVTFrrggKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPkgtLIEGGMTVDGHDIM 80
Cdd:COG3842    1 MAM---PALELENVSKRY----GDVTALDDVSLSIEPGEFVALLGPSGCGKTTLLRMIAGFET---PDSGRILLDGRDVT 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  81 SLS-NRalsdlRGavVSMVFQepRLALDPVYTVgrqiEETIM---RHEKVSRGLAAERALALFQKVRIPSPERRlsnYPH 156
Cdd:COG3842   71 GLPpEK-----RN--VGMVFQ--DYALFPHLTV----AENVAfglRMRGVPKAEIRARVAELLELVGLEGLADR---YPH 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 157 EMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRI 236
Cdd:COG3842  135 QLSGGQQQRVALARALAPEPRVLLLDEPLSALDAKLREEMREELRRLQRELGITFIYVTHDQEEALALADRIAVMNDGRI 214

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 523689182 237 VEEGLVGDIIRNPRHPYTKGLLGA----RVELAEGRDRLVTIPGAP---PDLAAMPPG 287
Cdd:COG3842  215 EQVGTPEEIYERPATRFVADFIGEanllPGTVLGDEGGGVRTGGRTlevPADAGLAAG 272

FepC

COG1120

ABC-type cobalamin/Fe3+-siderophores transport system, ATPase component [Inorganic ion ...

8-246

8.34e-55

ABC-type cobalamin/Fe3+-siderophores transport system, ATPase component [Inorganic ion transport and metabolism, Coenzyme transport and metabolism];

Pssm-ID: 440737 [Multi-domain] Cd Length: 254 Bit Score: 179.08 E-value: 8.34e-55

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSvtFRRGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPkgtLIEGGMTVDGHDIMSLSNRAL 87
Cdd:COG1120    1 MLEAENLS--VGYGGRPV--LDDVSLSLPPGEVTALLGPNGSGKSTLLRALAGLLK---PSSGEVLLDGRDLASLSRREL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  88 SdlrgAVVSMVFQEPRLALDpvYTVgrqiEETIMR----HEKVSRGL------AAERALALFQ--KVRipspERRLsnyp 155
Cdd:COG1120   74 A----RRIAYVPQEPPAPFG--LTV----RELVALgrypHLGLFGRPsaedreAVEEALERTGleHLA----DRPV---- 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 156 HEMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGR 235
Cdd:COG1120  136 DELSGGERQRVLIARALAQEPPLLLLDEPTSHLDLAHQLEVLELLRRLARERGRTVVMVLHDLNLAARYADRLVLLKDGR 215

                        250
                 ....*....|.
gi 523689182 236 IVEEGLVGDII 246
Cdd:COG1120  216 IVAQGPPEEVL 226

metN

PRK11153

DL-methionine transporter ATP-binding subunit; Provisional

8-278

1.34e-54

DL-methionine transporter ATP-binding subunit; Provisional

Pssm-ID: 236863 [Multi-domain] Cd Length: 343 Bit Score: 181.54 E-value: 1.34e-54

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSVTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSvtmrSLLRL-----HP-KGTLIeggmtVDGHDIMS 81
Cdd:PRK11153   1 MIELKNISKVFPQGGRTIHALNNVSLHIPAGEIFGVIGASGAGKS----TLIRCinlleRPtSGRVL-----VDGQDLTA 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  82 LSNRALSDLRGAVvSMVFQEPRLAldpvytVGRQIEETI---MRHEKVSRGLAAERALALFQKVRIPSPERRlsnYPHEM 158
Cdd:PRK11153  72 LSEKELRKARRQI-GMIFQHFNLL------SSRTVFDNValpLELAGTPKAEIKARVTELLELVGLSDKADR---YPAQL 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 159 SGGMLQRAMIAMALACNPKVLLADEPTTALD-ATVQiQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIV 237
Cdd:PRK11153 142 SGGQKQRVAIARALASNPKVLLCDEATSALDpATTR-SILELLKDINRELGLTIVLITHEMDVVKRICDRVAVIDAGRLV 220

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 523689182 238 EEGLVGDIIRNPRHPYTKGLLGA--RVELAEGRDRLVTIPGAP 278
Cdd:PRK11153 221 EQGTVSEVFSHPKHPLTREFIQStlHLDLPEDYLARLQAEPTT 263

PRK10261

glutathione transporter ATP-binding protein; Provisional

18-260

5.28e-54

glutathione transporter ATP-binding protein; Provisional

Pssm-ID: 182342 [Multi-domain] Cd Length: 623 Bit Score: 186.21 E-value: 5.28e-54

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  18 FRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGtliEGGMTVDGHDIMSLSNRALSDLRGAVvSM 97
Cdd:PRK10261 330 LNRVTREVHAVEKVSFDLWPGETLSLVGESGSGKSTTGRALLRLVESQ---GGEIIFNGQRIDTLSPGKLQALRRDI-QF 405

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  98 VFQEPRLALDPVYTVGRQIEETIMRHEKVSRGLAAERALALFQKVRIpSPERRLsNYPHEMSGGMLQRAMIAMALACNPK 177
Cdd:PRK10261 406 IFQDPYASLDPRQTVGDSIMEPLRVHGLLPGKAAAARVAWLLERVGL-LPEHAW-RYPHEFSGGQRQRICIARALALNPK 483

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 178 VLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDIIRNPRHPYTKGL 257
Cdd:PRK10261 484 VIIADEAVSALDVSIRGQIINLLLDLQRDFGIAYLFISHDMAVVERISHRVAVMYLGQIVEIGPRRAVFENPQHPYTRKL 563


                 ...
gi 523689182 258 LGA 260
Cdd:PRK10261 564 MAA 566

CcmA

COG1131

ABC-type multidrug transport system, ATPase component [Defense mechanisms];

9-247

6.68e-54

ABC-type multidrug transport system, ATPase component [Defense mechanisms];

Pssm-ID: 440746 [Multi-domain] Cd Length: 236 Bit Score: 176.02 E-value: 6.68e-54

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTFRRggkaVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGtliEGGMTVDGHDIMSLSNRALs 88
Cdd:COG1131    1 IEVRGLTKRYGD----KTALDGVSLTVEPGEIFGLLGPNGAGKTTTIRMLLGLLRPT---SGEVRVLGEDVARDPAEVR- 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  89 dlrgAVVSMVFQEPrlALDPVYTVgRQIEETIMRHEKVSRGLAAERALALFQKVRI-PSPERRLSNYphemSGGMLQRAM 167
Cdd:COG1131   73 ----RRIGYVPQEP--ALYPDLTV-RENLRFFARLYGLPRKEARERIDELLELFGLtDAADRKVGTL----SGGMKQRLG 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 168 IAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDIIR 247
Cdd:COG1131  142 LALALLHDPELLILDEPTSGLDPEARRELWELLRELAAE-GKTVLLSTHYLEEAERLCDRVAIIDKGRIVADGTPDELKA 220

TauB

COG1116

ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion ...

1-239

9.11e-54

ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism];

Pssm-ID: 440733 [Multi-domain] Cd Length: 260 Bit Score: 176.43 E-value: 9.11e-54

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   1 MTMqNDAMIDISNLSVTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSvtmrSLLRL-----HPkgtlIEGGMTVD 75
Cdd:COG1116    1 MSA-AAPALELRGVSKRFPTGGGGVTALDDVSLTVAAGEFVALVGPSGCGKS----TLLRLiagleKP----TSGEVLVD 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  76 GHDIMSLSNRalsdlrgavVSMVFQEPRL-----ALDPVyTVGrqieetiMRHEKVSRGLAAERALALFQKVRIpspERR 150
Cdd:COG1116   72 GKPVTGPGPD---------RGVVFQEPALlpwltVLDNV-ALG-------LELRGVPKAERRERARELLELVGL---AGF 131

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 151 LSNYPHEMSGGMLQRAMIAMALACNPKVLLADEPTTALDA-T-VQIQILLLirELQREYGLSVIFVTHDIGVAAEVADRI 228
Cdd:COG1116  132 EDAYPHQLSGGMRQRVAIARALANDPEVLLMDEPFGALDAlTrERLQDELL--RLWQETGKTVLFVTHDVDEAVFLADRV 209

                        250
                 ....*....|...
gi 523689182 229 AVMYA--GRIVEE 239
Cdd:COG1116  210 VVLSArpGRIVEE 222

ABC_OpuCA_Osmoprotection

cd03295

ATP-binding cassette domain of the osmoprotectant transporter; OpuCA is a the ATP binding ...

15-264

2.00e-51

ATP-binding cassette domain of the osmoprotectant transporter; OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition, to the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213262 [Multi-domain] Cd Length: 242 Bit Score: 170.17 E-value: 2.00e-51

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  15 SVTFRRGGKAvKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRL-HPKgtliEGGMTVDGHDIMSLSnraLSDLRGA 93
Cdd:cd03295    5 NVTKRYGGGK-KAVNNLNLEIAKGEFLVLIGPSGSGKTTTMKMINRLiEPT----SGEIFIDGEDIREQD---PVELRRK 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  94 VvSMVFQEprLALDPVYTVGRQIEeTIMRHEKVSRGLAAERALALFQKVRIPsPERRLSNYPHEMSGGMLQRAMIAMALA 173
Cdd:cd03295   77 I-GYVIQQ--IGLFPHMTVEENIA-LVPKLLKWPKEKIRERADELLALVGLD-PAEFADRYPHELSGGQQQRVGVARALA 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 174 CNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDIIRNPRHPY 253
Cdd:cd03295  152 ADPPLLLMDEPFGALDPITRDQLQEEFKRLQQELGKTIVFVTHDIDEAFRLADRIAIMKNGEIVQVGTPDEILRSPANDF 231

                        250
                 ....*....|.
gi 523689182 254 TKGLLGARVEL 264
Cdd:cd03295  232 VAEFVGADRLL 242

ABC_NrtD_SsuB_transporters

cd03293

ATP-binding cassette domain of the nitrate and sulfonate transporters; NrtD and SsuB are the ...

9-239

2.19e-51

ATP-binding cassette domain of the nitrate and sulfonate transporters; NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213260 [Multi-domain] Cd Length: 220 Bit Score: 169.19 E-value: 2.19e-51

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSvtmrSLLRL-----HPKgtliEGGMTVDGHDIMSLS 83
Cdd:cd03293    1 LEVRNVSKTYGGGGGAVTALEDISLSVEEGEFVALVGPSGCGKS----TLLRIiagleRPT----SGEVLVDGEPVTGPG 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  84 NRalsdlrgavVSMVFQEPRLAldPVYTVgrqiEETIM---RHEKVSRGLAAERALALFQKVRIPSPERRlsnYPHEMSG 160
Cdd:cd03293   73 PD---------RGYVFQQDALL--PWLTV----LDNVAlglELQGVPKAEARERAEELLELVGLSGFENA---YPHQLSG 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 161 GMLQRAMIAMALACNPKVLLADEPTTALDA-T-VQIQILLLirELQREYGLSVIFVTHDIGVAAEVADRIAVMYA--GRI 236
Cdd:cd03293  135 GMRQRVALARALAVDPDVLLLDEPFSALDAlTrEQLQEELL--DIWRETGKTVLLVTHDIDEAVFLADRVVVLSArpGRI 212


                 ...
gi 523689182 237 VEE 239
Cdd:cd03293  213 VAE 215

ABC_Org_Solvent_Resistant

cd03261

ATP-binding cassette transport system involved in resistance to organic solvents; ABC ...

9-255

4.23e-51

ATP-binding cassette transport system involved in resistance to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213228 [Multi-domain] Cd Length: 235 Bit Score: 168.83 E-value: 4.23e-51

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTFrrGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRL-HPKGtlieGGMTVDGHDIMSLSNRAL 87
Cdd:cd03261    1 IELRGLTKSF--GGRTV--LKGVDLDVRRGEILAIIGPSGSGKSTLLRLIVGLlRPDS----GEVLIDGEDISGLSEAEL 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  88 SDLRgAVVSMVFQEPrlALDPVYTVGRQIEETIMRHEKVSRGLAAERALALFQKVRIPSPERRlsnYPHEMSGGMLQRAM 167
Cdd:cd03261   73 YRLR-RRMGMLFQSG--ALFDSLTVFENVAFPLREHTRLSEEEIREIVLEKLEAVGLRGAEDL---YPAELSGGMKKRVA 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 168 IAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDiIR 247
Cdd:cd03261  147 LARALALDPELLLYDEPTAGLDPIASGVIDDLIRSLKKELGLTSIMVTHDLDTAFAIADRIAVLYDGKIVAEGTPEE-LR 225


                 ....*...
gi 523689182 248 NPRHPYTK 255
Cdd:cd03261  226 ASDDPLVR 233

ABC_Carb_Solutes_like

cd03259

ATP-binding cassette domain of the carbohydrate and solute transporters-like; This family is ...

9-240

3.30e-50

ATP-binding cassette domain of the carbohydrate and solute transporters-like; This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213226 [Multi-domain] Cd Length: 213 Bit Score: 165.77 E-value: 3.30e-50

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTFRrggkAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHpkgTLIEGGMTVDGHDIMSLSNRals 88
Cdd:cd03259    1 LELKGLSKTYG----SVRALDDLSLTVEPGEFLALLGPSGCGKTTLLRLIAGLE---RPDSGEILIDGRDVTGVPPE--- 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  89 dLRGavVSMVFQEPrlALDPVYTVgrqiEETI---MRHEKVSRGLAAERALALFQKVRIPSPERRlsnYPHEMSGGMLQR 165
Cdd:cd03259   71 -RRN--IGMVFQDY--ALFPHLTV----AENIafgLKLRGVPKAEIRARVRELLELVGLEGLLNR---YPHELSGGQQQR 138

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 523689182 166 AMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEG 240
Cdd:cd03259  139 VALARALAREPSLLLLDEPLSALDAKLREELREELKELQRELGITTIYVTHDQEEALALADRIAVMNEGRIVQVG 213

CysA

COG1118

ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and ...

9-291

7.66e-50

ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism];

Pssm-ID: 440735 [Multi-domain] Cd Length: 348 Bit Score: 169.17 E-value: 7.66e-50

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTFrrggKAVKAVNGVSLSVKPGEVVALLGESGSGKSvtmrSLLRL-----HP-KGTLIeggmtVDGHDIMSl 82
Cdd:COG1118    3 IEVRNISKRF----GSFTLLDDVSLEIASGELVALLGPSGSGKT----TLLRIiagleTPdSGRIV-----LNGRDLFT- 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  83 sNRALSDLRgavVSMVFQEPrlALDPVYTVgrqiEETI---MRHEKVSRGLAAERALALFQKVRIPSPERRlsnYPHEMS 159
Cdd:COG1118   69 -NLPPRERR---VGFVFQHY--ALFPHMTV----AENIafgLRVRPPSKAEIRARVEELLELVQLEGLADR---YPSQLS 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 160 GGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEE 239
Cdd:COG1118  136 GGQRQRVALARALAVEPEVLLLDEPFGALDAKVRKELRRWLRRLHDELGGTTVFVTHDQEEALELADRVVVMNQGRIEQV 215

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 523689182 240 GLVGDIIRNPRHPYTKGLLGA----RVELAEGRDRLVTIPgaPPDLAAMPPGCAFA 291
Cdd:COG1118  216 GTPDEVYDRPATPFVARFLGCvnvlRGRVIGGQLEADGLT--LPVAEPLPDGPAVA 269

YbbA

COG4181

Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase ...

1-239

1.09e-46

Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport and catabolism];

Pssm-ID: 443338 [Multi-domain] Cd Length: 233 Bit Score: 157.60 E-value: 1.09e-46

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   1 MTMQNDAMIDISNLSVTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSvtmrSLLRL-----HPKgtliEGGMTVD 75
Cdd:COG4181    1 MSSSSAPIIELRGLTKTVGTGAGELTILKGISLEVEAGESVAIVGASGSGKS----TLLGLlagldRPT----SGTVRLA 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  76 GHDIMSLSNRALSDLRGAVVSMVFQE----PRL-ALDPVytvgrqieetIMRHEKVSRGLAAERALALFQKVRIpspERR 150
Cdd:COG4181   73 GQDLFALDEDARARLRARHVGFVFQSfqllPTLtALENV----------MLPLELAGRRDARARARALLERVGL---GHR 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 151 LSNYPHEMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEvADRIAV 230
Cdd:COG4181  140 LDHYPAQLSGGEQQRVALARAFATEPAILFADEPTGNLDAATGEQIIDLLFELNRERGTTLVLVTHDPALAAR-CDRVLR 218


                 ....*....
gi 523689182 231 MYAGRIVEE 239
Cdd:COG4181  219 LRAGRLVED 227

EcfA2

COG1122

Energy-coupling factor transporter ATP-binding protein EcfA2 [Inorganic ion transport and ...

9-250

1.56e-46

Energy-coupling factor transporter ATP-binding protein EcfA2 [Inorganic ion transport and metabolism, General function prediction only];

Pssm-ID: 440739 [Multi-domain] Cd Length: 230 Bit Score: 157.11 E-value: 1.56e-46

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTFRRGgkaVKAVNGVSLSVKPGEVVALLGESGSGKSvtmrSLLR-----LHPKgtliEGGMTVDGHDImslS 83
Cdd:COG1122    1 IELENLSFSYPGG---TPALDDVSLSIEKGEFVAIIGPNGSGKS----TLLRllnglLKPT----SGEVLVDGKDI---T 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  84 NRALSDLRgAVVSMVFQEPRLALdpvytVGRQIEETIM---RHEKVSRGLAAERALALFQKVRIPSPERRlsnYPHEMSG 160
Cdd:COG1122   67 KKNLRELR-RKVGLVFQNPDDQL-----FAPTVEEDVAfgpENLGLPREEIRERVEEALELVGLEHLADR---PPHELSG 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 161 GMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEG 240
Cdd:COG1122  138 GQKQRVAIAGVLAMEPEVLVLDEPTAGLDPRGRRELLELLKRLNKE-GKTVIIVTHDLDLVAELADRVIVLDDGRIVADG 216

                        250
                 ....*....|
gi 523689182 241 LVGDIIRNPR 250
Cdd:COG1122  217 TPREVFSDYE 226

ABC_HisP_GlnQ

cd03262

ATP-binding cassette domain of the histidine and glutamine transporters; HisP and GlnQ are the ...

9-236

4.48e-46

ATP-binding cassette domain of the histidine and glutamine transporters; HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, respectively. Histidine permease is a multi-subunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP has properties intermediate between those of integral and peripheral membrane proteins and is accessible from both sides of the membrane, presumably by its interaction with HisQ and HisM. The two HisP subunits form a homodimer within the complex. The domain structure of the amino acid uptake systems is typical for prokaryotic extracellular solute binding protein-dependent uptake systems. All of the amino acid uptake systems also have at least one, and in a few cases, two extracellular solute binding proteins located in the periplasm of Gram-negative bacteria, or attached to the cell membrane of Gram-positive bacteria. The best-studied member of the PAAT (polar amino acid transport) family is the HisJQMP system of S. typhimurium, where HisJ is the extracellular solute binding proteins and HisP is the ABC protein.

Pssm-ID: 213229 [Multi-domain] Cd Length: 213 Bit Score: 155.38 E-value: 4.48e-46

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTFrrGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPkgtlIEGG-MTVDGHDImSLSNRAL 87
Cdd:cd03262    1 IEIKNLHKSF--GDFHV--LKGIDLTVKKGEVVVIIGPSGSGKSTLLRCINLLEE----PDSGtIIIDGLKL-TDDKKNI 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  88 SDLRgAVVSMVFQepRLALDPVYTVGRQIEETIMRHEKVSRGLAAERALALFQKVRIPSperRLSNYPHEMSGGMLQRAM 167
Cdd:cd03262   72 NELR-QKVGMVFQ--QFNLFPHLTVLENITLAPIKVKGMSKAEAEERALELLEKVGLAD---KADAYPAQLSGGQQQRVA 145

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 523689182 168 IAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAGRI 236
Cdd:cd03262  146 IARALAMNPKVMLFDEPTSALDPELVGEVLDVMKDLAEE-GMTMVVVTHEMGFAREVADRVIFMDDGRI 213

LolD_lipo_ex

TIGR02211

lipoprotein releasing system, ATP-binding protein; This model represents LolD, a member of the ...

13-238

6.47e-46

lipoprotein releasing system, ATP-binding protein; This model represents LolD, a member of the ABC transporter family (pfam00005). LolD is involved in localization of lipoproteins in some bacteria. It works with a transmembrane protein LolC, which in some species is a paralogous pair LolC and LolE. Depending on whether the residue immediately following the new, modified N-terminal Cys residue, the nascent lipoprotein may be carried further by LolA and LolB to the outer membrane, or remain at the inner membrane. The top scoring proteins excluded by this model include homologs from the archaeal genus Methanosarcina. [Protein fate, Protein and peptide secretion and trafficking]

Pssm-ID: 131266 [Multi-domain] Cd Length: 221 Bit Score: 155.20 E-value: 6.47e-46

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   13 NLSVTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSvTMrsllrLHPKGTL---IEGGMTVDGHDIMSLSNRALSD 89
Cdd:TIGR02211   6 NLGKRYQEGKLDTRVLKGVSLSIGKGEIVAIVGSSGSGKS-TL-----LHLLGGLdnpTSGEVLFNGQSLSKLSSNERAK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   90 LRGAVVSMVFQEPRLALDpvYTVgrqIEETIMRH--EKVSRGLAAERALALFQKVRIpspERRLSNYPHEMSGGMLQRAM 167
Cdd:TIGR02211  80 LRNKKLGFIYQFHHLLPD--FTA---LENVAMPLliGKKSVKEAKERAYEMLEKVGL---EHRINHRPSELSGGERQRVA 151

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 523689182  168 IAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEvADRIAVMYAGRIVE 238
Cdd:TIGR02211 152 IARALVNQPSLVLADEPTGNLDNNNAKIIFDLMLELNRELNTSFLVVTHDLELAKK-LDRVLEMKDGQLFN 221

ABC_Iron-Siderophores_B12_Hemin

cd03214

ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related ...

10-240

8.13e-46

ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC transporter mediating vitamin B12 uptake. The two ATP-binding cassettes (BtuD) are in close contact with each other, as are the two membrane-spanning subunits (BtuC); this arrangement is distinct from that observed for the E. coli lipid flippase MsbA. The BtuC subunits provide 20 transmembrane helices grouped around a translocation pathway that is closed to the cytoplasm by a gate region, whereas the dimer arrangement of the BtuD subunits resembles the ATP-bound form of the Rad50 DNA repair enzyme. A prominent cytoplasmic loop of BtuC forms the contact region with the ATP-binding cassette and represent a conserved motif among the ABC transporters.

Pssm-ID: 213181 [Multi-domain] Cd Length: 180 Bit Score: 153.36 E-value: 8.13e-46

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  10 DISNLSvtFRRGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPkgtLIEGGMTVDGHDIMSLSNRALSD 89
Cdd:cd03214    1 EVENLS--VGYGGRTV--LDDLSLSIEAGEIVGILGPNGAGKSTLLKTLAGLLK---PSSGEILLDGKDLASLSPKELAR 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  90 LRgAVVSMVfqeprlaldpvytvgrqIEETIMRHekvsrglaaeraLAlfqkvripspERRLSnyphEMSGGMLQRAMIA 169
Cdd:cd03214   74 KI-AYVPQA-----------------LELLGLAH------------LA----------DRPFN----ELSGGERQRVLLA 109

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 523689182 170 MALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEG 240
Cdd:cd03214  110 RALAQEPPILLLDEPTSHLDIAHQIELLELLRRLARERGKTVVMVLHDLNLAARYADRVILLKDGRIVAQG 180

phnK

PRK11701

phosphonate C-P lyase system protein PhnK; Provisional

24-257

1.82e-45

phosphonate C-P lyase system protein PhnK; Provisional

Pssm-ID: 183280 [Multi-domain] Cd Length: 258 Bit Score: 155.08 E-value: 1.82e-45

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  24 AVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSL-LRLHP-KGTLIEGGMTVDGHDIMSLSN---RALSDLRGAVVSmv 98
Cdd:PRK11701  18 PRKGCRDVSFDLYPGEVLGIVGESGSGKTTLLNALsARLAPdAGEVHYRMRDGQLRDLYALSEaerRRLLRTEWGFVH-- 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  99 fQEPRLALDPVYTVGRQIEETIM----RHEKVSRglaaERALALFQKVRIPSpeRRLSNYPHEMSGGMLQRAMIAMALAC 174
Cdd:PRK11701  96 -QHPRDGLRMQVSAGGNIGERLMavgaRHYGDIR----ATAGDWLERVEIDA--ARIDDLPTTFSGGMQQRLQIARNLVT 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 175 NPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDIIRNPRHPYT 254
Cdd:PRK11701 169 HPRLVFMDEPTGGLDVSVQARLLDLLRGLVRELGLAVVIVTHDLAVARLLAHRLLVMKQGRVVESGLTDQVLDDPQHPYT 248


                 ...
gi 523689182 255 KGL 257
Cdd:PRK11701 249 QLL 251

nickel_nikE

TIGR02769

nickel import ATP-binding protein NikE; This family represents the NikE subunit of a ...

7-260

2.61e-45

nickel import ATP-binding protein NikE; This family represents the NikE subunit of a multisubunit nickel import ABC transporter complex. Nickel, once imported, may be used in urease and in certain classes of hydrogenase and superoxide dismutase. [Transport and binding proteins, Cations and iron carrying compounds]

Pssm-ID: 131816 [Multi-domain] Cd Length: 265 Bit Score: 154.96 E-value: 2.61e-45

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182    7 AMIDISNLSVTFRRGG----KAVKAV-NGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGtliEGGMTVDGHDIMS 81
Cdd:TIGR02769   1 SLLEVRDVTHTYRTGGlfgaKQRAPVlTNVSLSIEEGETVGLLGRSGCGKSTLARLLLGLEKPA---QGTVSFRGQDLYQ 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   82 LSNRALSDLRgAVVSMVFQEPRLALDPVYTVGRQIEETIMRHEKVSRGLAAERALALFQKVRIPSPERRlsNYPHEMSGG 161
Cdd:TIGR02769  78 LDRKQRRAFR-RDVQLVFQDSPSAVNPRMTVRQIIGEPLRHLTSLDESEQKARIAELLDMVGLRSEDAD--KLPRQLSGG 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  162 MLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGL 241
Cdd:TIGR02769 155 QLQRINIARALAVKPKLIVLDEAVSNLDMVLQAVILELLRKLQQAFGTAYLFITHDLRLVQSFCQRVAVMDKGQIVEECD 234

                         250
                  ....*....|....*....
gi 523689182  242 VGDIIrNPRHPYTKGLLGA 260
Cdd:TIGR02769 235 VAQLL-SFKHPAGRNLQSA 252

PRK15134

microcin C ABC transporter ATP-binding protein YejF; Provisional

8-258

3.50e-45

microcin C ABC transporter ATP-binding protein YejF; Provisional

Pssm-ID: 237917 [Multi-domain] Cd Length: 529 Bit Score: 161.03 E-value: 3.50e-45

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSVTF-------RRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKgtliEGGMTVDGHDIM 80
Cdd:PRK15134 275 LLDVEQLQVAFpirkgilKRTVDHNVVVKNISFTLRPGETLGLVGESGSGKSTTGLALLRLINS----QGEIWFDGQPLH 350

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  81 SLSNRALSDLRGAVvSMVFQEPRLALDPVYTVGRQIEETIMRHEKVSRGLAAE-RALALFQKVRIpSPERRlSNYPHEMS 159
Cdd:PRK15134 351 NLNRRQLLPVRHRI-QVVFQDPNSSLNPRLNVLQIIEEGLRVHQPTLSAAQREqQVIAVMEEVGL-DPETR-HRYPAEFS 427

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 160 GGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEE 239
Cdd:PRK15134 428 GGQRQRIAIARALILKPSLIILDEPTSSLDKTVQAQILALLKSLQQKHQLAYLFISHDLHVVRALCHQVIVLRQGEVVEQ 507

                        250
                 ....*....|....*....
gi 523689182 240 GLVGDIIRNPRHPYTKGLL 258
Cdd:PRK15134 508 GDCERVFAAPQQEYTRQLL 526

nikE

PRK10419

nickel ABC transporter ATP-binding protein NikE;

18-260

9.51e-45

nickel ABC transporter ATP-binding protein NikE;

Pssm-ID: 236689 [Multi-domain] Cd Length: 268 Bit Score: 153.69 E-value: 9.51e-45

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  18 FRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLH-PKGtlieGGMTVDGHDIMSLSNRALSDLRGAVvS 96
Cdd:PRK10419  18 LSGKHQHQTVLNNVSLSLKSGETVALLGRSGCGKSTLARLLVGLEsPSQ----GNVSWRGEPLAKLNRAQRKAFRRDI-Q 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  97 MVFQEPRLALDPVYTVGRQIEETiMRH-EKVSRGLAAERALALFQKVRIPspERRLSNYPHEMSGGMLQRAMIAMALACN 175
Cdd:PRK10419  93 MVFQDSISAVNPRKTVREIIREP-LRHlLSLDKAERLARASEMLRAVDLD--DSVLDKRPPQLSGGQLQRVCLARALAVE 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 176 PKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDIIRNpRHPYTK 255
Cdd:PRK10419 170 PKLLILDEAVSNLDLVLQAGVIRLLKKLQQQFGTACLFITHDLRLVERFCQRVMVMDNGQIVETQPVGDKLTF-SSPAGR 248


                 ....*
gi 523689182 256 GLLGA 260
Cdd:PRK10419 249 VLQNA 253

ABC_cobalt_CbiO_domain1

cd03225

First domain of the ATP-binding cassette component of cobalt transport system; Domain I of the ...

16-235

1.23e-44

First domain of the ATP-binding cassette component of cobalt transport system; Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC transport system of the CbiMNQO family is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most of cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems.

Pssm-ID: 213192 [Multi-domain] Cd Length: 211 Bit Score: 151.47 E-value: 1.23e-44

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  16 VTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKgtlIEGGMTVDGHDIMSLSNRALSdlrgAVV 95
Cdd:cd03225    5 LSFSYPDGARPALDDISLTIKKGEFVLIVGPNGSGKSTLLRLLNGLLGP---TSGEVLVDGKDLTKLSLKELR----RKV 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  96 SMVFQEPRLALdpvytVGRQIEETI---MRHEKVSRGLAAERALALFQKVRIPSPERRlsnYPHEMSGGMLQRAMIAMAL 172
Cdd:cd03225   78 GLVFQNPDDQF-----FGPTVEEEVafgLENLGLPEEEIEERVEEALELVGLEGLRDR---SPFTLSGGQKQRVAIAGVL 149

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 523689182 173 ACNPKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAGR 235
Cdd:cd03225  150 AMDPDILLLDEPTAGLDPAGRRELLELLKKLKAE-GKTIIIVTHDLDLLLELADRVIVLEDGK 211

OpuBA

COG1125

ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and ...

8-260

2.76e-44

ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism];

Pssm-ID: 440742 [Multi-domain] Cd Length: 306 Bit Score: 153.32 E-value: 2.76e-44

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSVTFrrgGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLhpkgtlIE---GGMTVDGHDIMSLSn 84
Cdd:COG1125    1 MIEFENVTKRY---PDGTVAVDDLSLTIPAGEFTVLVGPSGCGKTTTLRMINRL------IEptsGRILIDGEDIRDLD- 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  85 raLSDLR---GAVVsmvfQEPrlALDPVYTVGRQIEeTIMRHEKVSRGLAAERALALFQKVRIPsPERRLSNYPHEMSGG 161
Cdd:COG1125   71 --PVELRrriGYVI----QQI--GLFPHMTVAENIA-TVPRLLGWDKERIRARVDELLELVGLD-PEEYRDRYPHELSGG 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 162 MLQRAMIAMALACNPKVLLADEPTTALDATV--QIQILLLirELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEE 239
Cdd:COG1125  141 QQQRVGVARALAADPPILLMDEPFGALDPITreQLQDELL--RLQRELGKTIVFVTHDIDEALKLGDRIAVMREGRIVQY 218

                        250       260
                 ....*....|....*....|.
gi 523689182 240 GLVGDIIRNPRHPYTKGLLGA 260
Cdd:COG1125  219 DTPEEILANPANDFVADFVGA 239

ECF_ATPase_2

TIGR04521

energy-coupling factor transporter ATPase; Members of this family are ATP-binding cassette ...

9-240

4.74e-44

energy-coupling factor transporter ATPase; Members of this family are ATP-binding cassette (ABC) proteins by homology, but belong to energy coupling factor (ECF) transport systems. The architecture in general is two ATPase subunits (or a double-length fusion protein), a T component, and a substrate capture (S) component that is highly variable, and may be interchangeable in genomes with only one T component. This model identifies many but not examples of the downstream member of the pair of ECF ATPases in Firmicutes and Mollicutes. [Transport and binding proteins, Unknown substrate]

Pssm-ID: 275314 [Multi-domain] Cd Length: 277 Bit Score: 151.84 E-value: 4.74e-44

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182    9 IDISNLSVTFRRGGK-AVKAVNGVSLSVKPGEVVALLGESGSGKSvTMRSLLR--LHP-KGTLieggmTVDGHDIMSLSN 84
Cdd:TIGR04521   1 IKLKNVSYIYQPGTPfEKKALDDVSLTIEDGEFVAIIGHTGSGKS-TLIQHLNglLKPtSGTV-----TIDGRDITAKKK 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   85 RALSDLRgAVVSMVFQEPRlaldpvytvgRQI-EETIM-------RHEKVSRGLAAERALALFQKVRIPspERRLSNYPH 156
Cdd:TIGR04521  75 KKLKDLR-KKVGLVFQFPE----------HQLfEETVYkdiafgpKNLGLSEEEAEERVKEALELVGLD--EEYLERSPF 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  157 EMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRI 236
Cdd:TIGR04521 142 ELSGGQMRRVAIAGVLAMEPEVLILDEPTAGLDPKGRKEILDLFKRLHKEKGLTVILVTHSMEDVAEYADRVIVMHKGKI 221


                  ....
gi 523689182  237 VEEG 240
Cdd:TIGR04521 222 VLDG 225

ABC_Pro_Gly_Betaine

cd03294

ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; This ...

23-262

5.90e-44

ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporters is the obligatory coupling of ATP hydrolysis to substrate translocation. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213261 [Multi-domain] Cd Length: 269 Bit Score: 151.64 E-value: 5.90e-44

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  23 KAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLhpkgtlIE---GGMTVDGHDIMSLSNRALSDLRGAVVSMVF 99
Cdd:cd03294   35 GQTVGVNDVSLDVREGEIFVIMGLSGSGKSTLLRCINRL------IEptsGKVLIDGQDIAAMSRKELRELRRKKISMVF 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 100 QEprLALDPVYTVGRQIEETI-MRHekVSRGLAAERALALFQKVRIpspERRLSNYPHEMSGGMLQRAMIAMALACNPKV 178
Cdd:cd03294  109 QS--FALLPHRTVLENVAFGLeVQG--VPRAEREERAAEALELVGL---EGWEHKYPDELSGGMQQRVGLARALAVDPDI 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 179 LLADEPTTALDATV--QIQILLLirELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDIIRNPRHPY--- 253
Cdd:cd03294  182 LLMDEAFSALDPLIrrEMQDELL--RLQAELQKTIVFITHDLDEALRLGDRIAIMKDGRLVQVGTPEEILTNPANDYvre 259

                        250
                 ....*....|
gi 523689182 254 -TKGLLGARV 262
Cdd:cd03294  260 fFRGVDRAKV 269

ABC_PhnC_transporter

cd03256

ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; ...

9-240

7.94e-44

ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all kingdoms of wildlife, but only prokaryotic microorganisms are able to cleave this bond. Certain bacteria such as E. coli can use alkylphosphonates as a phosphorus source. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213223 [Multi-domain] Cd Length: 241 Bit Score: 150.41 E-value: 7.94e-44

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTFRRGGKAVKavnGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHpkgTLIEGGMTVDGHDIMSLSNRALS 88
Cdd:cd03256    1 IEVENLSKTYPNGKKALK---DVSLSINPGEFVALIGPSGAGKSTLLRCLNGLV---EPTSGSVLIDGTDINKLKGKALR 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  89 DLRGAVvSMVFQEPRLaldpvytVGRQ--IEETIM----RHEKVsRGLAA-------ERALALFQKVRI-PSPERRLSny 154
Cdd:cd03256   75 QLRRQI-GMIFQQFNL-------IERLsvLENVLSgrlgRRSTW-RSLFGlfpkeekQRALAALERVGLlDKAYQRAD-- 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 155 phEMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAG 234
Cdd:cd03256  144 --QLSGGQQQRVAIARALMQQPKLILADEPVASLDPASSRQVMDLLKRINREEGITVIVSLHQVDLAREYADRIVGLKDG 221


                 ....*.
gi 523689182 235 RIVEEG 240
Cdd:cd03256  222 RIVFDG 227

proV

TIGR01186

glycine betaine/L-proline transport ATP binding subunit; This model describes the glycine ...

21-269

8.03e-44

glycine betaine/L-proline transport ATP binding subunit; This model describes the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. Functionally, this transport system is involved in osmoregulation. Under conditions of stress, the organism recruits these transport system to accumulate glycine betaine and other solutes which offer osmo-protection. It has been demonstrated that glycine betaine uptake is accompanied by symport with sodium ions. The locus has been named variously as proU or opuA. A gene library from L.lactis functionally complements an E.coli proU mutant. The comlementing locus is similar to a opuA locus in B.sutlis. This clarifies the differences in nomenclature. [Transport and binding proteins, Amino acids, peptides and amines]

Pssm-ID: 130254 [Multi-domain] Cd Length: 363 Bit Score: 153.85 E-value: 8.03e-44

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   21 GGKavKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLhpkgtlIE---GGMTVDGHDIMSLSNRALSDLRGAVVSM 97
Cdd:TIGR01186   4 GGK--KGVNDADLAIAKGEIFVIMGLSGSGKSTTVRMLNRL------IEptaGQIFIDGENIMKQSPVELREVRRKKIGM 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   98 VFQEprLALDPVYTVGRQIEeTIMRHEKVSRGLAAERALALFQKVRIPSPERRlsnYPHEMSGGMLQRAMIAMALACNPK 177
Cdd:TIGR01186  76 VFQQ--FALFPHMTILQNTS-LGPELLGWPEQERKEKALELLKLVGLEEYEHR---YPDELSGGMQQRVGLARALAAEPD 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  178 VLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDIIRNPRHPYTKGL 257
Cdd:TIGR01186 150 ILLMDEAFSALDPLIRDSMQDELKKLQATLQKTIVFITHDLDEAIRIGDRIVIMKAGEIVQVGTPDEILRNPANEYVEEF 229

                         250
                  ....*....|..
gi 523689182  258 LGaRVELAEGRD 269
Cdd:TIGR01186 230 IG-KVDLSQVFD 240

ABC_PotA_N

cd03300

ATP-binding cassette domain of the polyamine transporter; PotA is an ABC-type transporter and ...

9-249

1.24e-43

ATP-binding cassette domain of the polyamine transporter; PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required for homodimerization with PotA and heterdimerization with PotB. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213267 [Multi-domain] Cd Length: 232 Bit Score: 149.69 E-value: 1.24e-43

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTFrrGGKavKAVNGVSLSVKPGEVVALLGESGSGKSVTMRsllrlhpkgtLIEGGMTVDGHDIMsLSNRALS 88
Cdd:cd03300    1 IELENVSKFY--GGF--VALDGVSLDIKEGEFFTLLGPSGCGKTTLLR----------LIAGFETPTSGEIL-LDGKDIT 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  89 DL----RGavVSMVFQEprLALDPVYTVGRQIEETiMRHEKVSRGLAAERALALFQKVRIPSPERRlsnYPHEMSGGMLQ 164
Cdd:cd03300   66 NLpphkRP--VNTVFQN--YALFPHLTVFENIAFG-LRLKKLPKAEIKERVAEALDLVQLEGYANR---KPSQLSGGQQQ 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 165 RAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGD 244
Cdd:cd03300  138 RVAIARALVNEPKVLLLDEPLGALDLKLRKDMQLELKRLQKELGITFVFVTHDQEEALTMSDRIAVMNKGKIQQIGTPEE 217


                 ....*
gi 523689182 245 IIRNP 249
Cdd:cd03300  218 IYEEP 222

ABC_PstB_phosphate_transporter

cd03260

ATP-binding cassette domain of the phosphate transport system; Phosphate uptake is of ...

9-240

2.64e-43

ATP-binding cassette domain of the phosphate transport system; Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein is a phosphate-binding protein located in the periplasmic space. PstA and PstC are hydrophobic and they form the transmembrane portion of the Pst system. PstB is the catalytic subunit, which couples the energy of ATP hydrolysis to the import of phosphate across cellular membranes through the Pst system, often referred as ABC-protein. PstB belongs to one of the largest superfamilies of proteins characterized by a highly conserved adenosine triphosphate (ATP) binding cassette (ABC), which is also a nucleotide binding domain (NBD).

Pssm-ID: 213227 [Multi-domain] Cd Length: 227 Bit Score: 148.48 E-value: 2.64e-43

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSvtFRRGGKavKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHP--KGTLIEGGMTVDGHDIMSLSNRA 86
Cdd:cd03260    1 IELRDLN--VYYGDK--HALKDISLDIPKGEITALIGPSGCGKSTLLRLLNRLNDliPGAPDEGEVLLDGKDIYDLDVDV 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  87 LSdLRgAVVSMVFQEPRLALDPVY---TVG---RQIEETIMRHEKVSRGLaaERAlALFQKVripspERRLSnyPHEMSG 160
Cdd:cd03260   77 LE-LR-RRVGMVFQKPNPFPGSIYdnvAYGlrlHGIKLKEELDERVEEAL--RKA-ALWDEV-----KDRLH--ALGLSG 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 161 GMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYglSVIFVTHDIGVAAEVADRIAVMYAGRIVEEG 240
Cdd:cd03260  145 GQQQRLCLARALANEPEVLLLDEPTSALDPISTAKIEELIAELKKEY--TIVIVTHNMQQAARVADRTAFLLNGRLVEFG 222

CP_lyasePhnK

TIGR02323

phosphonate C-P lyase system protein PhnK; Members of this family are the PhnK protein of C-P ...

7-260

4.08e-43

phosphonate C-P lyase system protein PhnK; Members of this family are the PhnK protein of C-P lyase systems for utilization of phosphonates. These systems resemble phosphonatase-based systems in having a three component ABC transporter, where TIGR01097 is the permease, TIGR01098 is the phosphonates binding protein, and TIGR02315 is the ATP-binding cassette (ABC) protein. They differ, however, in having, typically, ten or more additional genes, many of which are believed to form a membrane-associated complex. This protein (PhnK) and the adjacent-encoded PhnL resemble transporter ATP-binding proteins but are suggested, based on mutatgenesis studies, to be part of this complex rather than part of a transporter per se. [Central intermediary metabolism, Phosphorus compounds]

Pssm-ID: 188208 [Multi-domain] Cd Length: 253 Bit Score: 148.83 E-value: 4.08e-43

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182    7 AMIDISNLSVTFRRGgkavKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLL-RLHPK-GTLIEGGMTVDGHDIMSLSN 84
Cdd:TIGR02323   2 PLLQVSGLSKSYGGG----KGCRDVSFDLYPGEVLGIVGESGSGKSTLLGCLAgRLAPDhGTATYIMRSGAELELYQLSE 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   85 RALSDLRGAVVSMVFQEPRLALDPVYTVGRQIEETIMRHEKVSRGLAAERALALFQKVRIPspERRLSNYPHEMSGGMLQ 164
Cdd:TIGR02323  78 AERRRLMRTEWGFVHQNPRDGLRMRVSAGANIGERLMAIGARHYGNIRATAQDWLEEVEID--PTRIDDLPRAFSGGMQQ 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  165 RAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGD 244
Cdd:TIGR02323 156 RLQIARNLVTRPRLVFMDEPTGGLDVSVQARLLDLLRGLVRDLGLAVIIVTHDLGVARLLAQRLLVMQQGRVVESGLTDQ 235

                         250
                  ....*....|....*.
gi 523689182  245 IIRNPRHPYTKGLLGA 260
Cdd:TIGR02323 236 VLDDPQHPYTQLLVSS 251

ABC_CysA_sulfate_importer

cd03296

ATP-binding cassette domain of the sulfate transporter; Part of the ABC transporter complex ...

9-260

4.85e-43

ATP-binding cassette domain of the sulfate transporter; Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a solute-binding protein (cysP). ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213263 [Multi-domain] Cd Length: 239 Bit Score: 148.26 E-value: 4.85e-43

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTFRRggkaVKAVNGVSLSVKPGEVVALLGESGSGKSvtmrSLLRL-----HP-KGTLIEGGMTVDGHDImsl 82
Cdd:cd03296    3 IEVRNVSKRFGD----FVALDDVSLDIPSGELVALLGPSGSGKT----TLLRLiagleRPdSGTILFGGEDATDVPV--- 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  83 snralsdlRGAVVSMVFQEprLALDPVYTVGRQIE---ETIMRHEKVSRGLAAERALALFQKVRIPSPERRlsnYPHEMS 159
Cdd:cd03296   72 --------QERNVGFVFQH--YALFRHMTVFDNVAfglRVKPRSERPPEAEIRAKVHELLKLVQLDWLADR---YPAQLS 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 160 GGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEE 239
Cdd:cd03296  139 GGQRQRVALARALAVEPKVLLLDEPFGALDAKVRKELRRWLRRLHDELHVTTVFVTHDQEEALEVADRVVVMNKGRIEQV 218

                        250       260
                 ....*....|....*....|.
gi 523689182 240 GLVGDIIRNPRHPYTKGLLGA 260
Cdd:cd03296  219 GTPDEVYDHPASPFVYSFLGE 239

PRK11264

putative amino-acid ABC transporter ATP-binding protein YecC; Provisional

7-258

4.87e-43

putative amino-acid ABC transporter ATP-binding protein YecC; Provisional

Pssm-ID: 183063 [Multi-domain] Cd Length: 250 Bit Score: 148.74 E-value: 4.87e-43

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   7 AMIDISNLSVTFRrgGKAVkaVNGVSLSVKPGEVVALLGESGSGKSVTMRS--LLRLHPKGTLIEGGMTVDGHDIMSLSN 84
Cdd:PRK11264   2 SAIEVKNLVKKFH--GQTV--LHGIDLEVKPGEVVAIIGPSGSGKTTLLRCinLLEQPEAGTIRVGDITIDTARSLSQQK 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  85 RALSDLRGAVvSMVFQEprLALDPVYTVGRQIEETIMRHEKVSRGLAAERALALFQKVRIPSPErrlSNYPHEMSGGMLQ 164
Cdd:PRK11264  78 GLIRQLRQHV-GFVFQN--FNLFPHRTVLENIIEGPVIVKGEPKEEATARARELLAKVGLAGKE---TSYPRRLSGGQQQ 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 165 RAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIfVTHDIGVAAEVADRIAVMYAGRIVEEGLVGD 244
Cdd:PRK11264 152 RVAIARALAMRPEVILFDEPTSALDPELVGEVLNTIRQLAQEKRTMVI-VTHEMSFARDVADRAIFMDQGRIVEQGPAKA 230

                        250
                 ....*....|....
gi 523689182 245 IIRNPRHPYTKGLL 258
Cdd:PRK11264 231 LFADPQQPRTRQFL 244

PstB

COG1117

ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; ...

1-255

1.11e-42

ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism];

Pssm-ID: 440734 [Multi-domain] Cd Length: 258 Bit Score: 147.88 E-value: 1.11e-42

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   1 MTMQNDAM---IDISNLSVTFrrGGKavKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLH---PkGTLIEGGMTV 74
Cdd:COG1117    1 MTAPASTLepkIEVRNLNVYY--GDK--QALKDINLDIPENKVTALIGPSGCGKSTLLRCLNRMNdliP-GARVEGEILL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  75 DGHDIMSlSNRALSDLRgAVVSMVFQEP---------------RLaldpvytvgrqieetimrHEKVSRGLAA---ERAL 136
Cdd:COG1117   76 DGEDIYD-PDVDVVELR-RRVGMVFQKPnpfpksiydnvayglRL------------------HGIKSKSELDeivEESL 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 137 ---ALFQKVRipspeRRLSNYPHEMSGGMLQRAMIAMALACNPKVLLADEPTTALD--ATVQIQilLLIRELQREYglSV 211
Cdd:COG1117  136 rkaALWDEVK-----DRLKKSALGLSGGQQQRLCIARALAVEPEVLLMDEPTSALDpiSTAKIE--ELILELKKDY--TI 206

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 523689182 212 IFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDIIRNPRHPYTK 255
Cdd:COG1117  207 VIVTHNMQQAARVSDYTAFFYLGELVEFGPTEQIFTNPKDKRTE 250

ABC_DR_subfamily_A

cd03230

ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily ...

9-236

4.05e-42

ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; This family of ATP-binding proteins belongs to a multi-subunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding protein and one or two integral membrane proteins. Eukaryotic systems of the ABCA subfamily display ABC domains that are quite similar to this family. The ATP-binding domain shows the highest similarity between all members of the ABC transporter family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213197 [Multi-domain] Cd Length: 173 Bit Score: 143.69 E-value: 4.05e-42

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTFRRGgkavKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHP--KGTLieggmTVDGHDIMSLSNRA 86
Cdd:cd03230    1 IEVRNLSKRYGKK----TALDDISLTVEKGEIYGLLGPNGAGKTTLIKIILGLLKpdSGEI-----KVLGKDIKKEPEEV 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  87 LSDlrgavVSMVFQEPRLalDPVYTVgrqiEETImrhekvsrglaaeralalfqkvripsperrlsnyphEMSGGMLQRA 166
Cdd:cd03230   72 KRR-----IGYLPEEPSL--YENLTV----RENL------------------------------------KLSGGMKQRL 104

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 167 MIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAGRI 236
Cdd:cd03230  105 ALAQALLHDPELLILDEPTSGLDPESRREFWELLRELKKE-GKTILLSSHILEEAERLCDRVAILNNGRI 173

NatA

COG4555

ABC-type Na+ transport system, ATPase component NatA [Energy production and conversion, ...

8-245

4.88e-42

ABC-type Na+ transport system, ATPase component NatA [Energy production and conversion, Inorganic ion transport and metabolism];

Pssm-ID: 443618 [Multi-domain] Cd Length: 243 Bit Score: 145.77 E-value: 4.88e-42

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSVTFrrggKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLR-LHPKgtliEGGMTVDGHDIMSLSNRA 86
Cdd:COG4555    1 MIEVENLSKKY----GKVPALKDVSFTAKDGEITGLLGPNGAGKTTLLRMLAGlLKPD----SGSILIDGEDVRKEPREA 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  87 LSDLrgavvSMVFQEPrlALDPVYTVGRQIEETIMRHeKVSRGLAAERALALFQKVRIPSP-ERRLsnypHEMSGGMLQR 165
Cdd:COG4555   73 RRQI-----GVLPDER--GLYDRLTVRENIRYFAELY-GLFDEELKKRIEELIELLGLEEFlDRRV----GELSTGMKKK 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 166 AMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELqREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDI 245
Cdd:COG4555  141 VALARALVHDPKVLLLDEPTNGLDVMARRLLREILRAL-KKEGKTVLFSSHIMQEVEALCDRVVILHKGKVVAQGSLDEL 219

ABC_Class3

cd03229

ATP-binding cassette domain of the binding protein-dependent transport systems; This class is ...

9-235

1.01e-41

ATP-binding cassette domain of the binding protein-dependent transport systems; This class is comprised of all BPD (Binding Protein Dependent) systems that are largely represented in archaea and eubacteria and are primarily involved in scavenging solutes from the environment. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213196 [Multi-domain] Cd Length: 178 Bit Score: 142.71 E-value: 1.01e-41

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTFrrggKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHpkgTLIEGGMTVDGHDIMSLsNRALS 88
Cdd:cd03229    1 LELKNVSKRY----GQKTVLNDVSLNIEAGEIVALLGPSGSGKSTLLRCIAGLE---EPDSGSILIDGEDLTDL-EDELP 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  89 DLRgAVVSMVFQEPRLaldpvytvgrqieetiMRHekvsrglaaeraLALFQKVRIPsperrlsnypheMSGGMLQRAMI 168
Cdd:cd03229   73 PLR-RRIGMVFQDFAL----------------FPH------------LTVLENIALG------------LSGGQQQRVAL 111

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 523689182 169 AMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGR 235
Cdd:cd03229  112 ARALAMDPDVLLLDEPTSALDPITRREVRALLKSLQAQLGITVVLVTHDLDEAARLADRVVVLRDGK 178

FtsE

COG2884

Cell division ATPase FtsE [Cell cycle control, cell division, chromosome partitioning];

8-243

2.16e-40

Cell division ATPase FtsE [Cell cycle control, cell division, chromosome partitioning];

Pssm-ID: 442130 [Multi-domain] Cd Length: 223 Bit Score: 140.96 E-value: 2.16e-40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSVTFRRGgkaVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLR-LHPKgtliEGGMTVDGHDIMSLSNRA 86
Cdd:COG2884    1 MIRFENVSKRYPGG---REALSDVSLEIEKGEFVFLTGPSGAGKSTLLKLLYGeERPT----SGQVLVNGQDLSRLKRRE 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  87 LSDLR---GavvsMVFQEPRLaLDpvytvGRQIEETI---MRHEKVSRGLAAERALALFQKVRIpspERRLSNYPHEMSG 160
Cdd:COG2884   74 IPYLRrriG----VVFQDFRL-LP-----DRTVYENValpLRVTGKSRKEIRRRVREVLDLVGL---SDKAKALPHELSG 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 161 GMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEG 240
Cdd:COG2884  141 GEQQRVAIARALVNRPELLLADEPTGNLDPETSWEIMELLEEINRR-GTTVLIATHDLELVDRMPKRVLELEDGRLVRDE 219


                 ...
gi 523689182 241 LVG 243
Cdd:COG2884  220 ARG 222

glnQ

PRK09493

glutamine ABC transporter ATP-binding protein GlnQ;

8-258

4.39e-40

glutamine ABC transporter ATP-binding protein GlnQ;

Pssm-ID: 181906 [Multi-domain] Cd Length: 240 Bit Score: 140.61 E-value: 4.39e-40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSVTFrrggKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHP--KGTLIEGGMTVDGHdimSLSNR 85
Cdd:PRK09493   1 MIEFKNVSKHF----GPTQVLHNIDLNIDQGEVVVIIGPSGSGKSTLLRCINKLEEitSGDLIVDGLKVNDP---KVDER 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  86 ALSDLRGavvsMVFQE----PRL-ALDPVYTVGRQIEetimrheKVSRGLAAERALALFQKVRIpspERRLSNYPHEMSG 160
Cdd:PRK09493  74 LIRQEAG----MVFQQfylfPHLtALENVMFGPLRVR-------GASKEEAEKQARELLAKVGL---AERAHHYPSELSG 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 161 GMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEG 240
Cdd:PRK09493 140 GQQQRVAIARALAVKPKLMLFDEPTSALDPELRHEVLKVMQDLAEE-GMTMVIVTHEIGFAEKVASRLIFIDKGRIAEDG 218

                        250
                 ....*....|....*...
gi 523689182 241 LVGDIIRNPRHPYTKGLL 258
Cdd:PRK09493 219 DPQVLIKNPPSQRLQEFL 236

3a0106s01

TIGR00968

sulfate ABC transporter, ATP-binding protein; [Transport and binding proteins, Anions]

9-260

8.00e-40

sulfate ABC transporter, ATP-binding protein; [Transport and binding proteins, Anions]

Pssm-ID: 130041 [Multi-domain] Cd Length: 237 Bit Score: 139.93 E-value: 8.00e-40

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182    9 IDISNLSVTFRRggkaVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRL-HPKgtliEGGMTVDGHDIMSLsnral 87
Cdd:TIGR00968   1 IEIANISKRFGS----FQALDDVNLEVPTGSLVALLGPSGSGKSTLLRIIAGLeQPD----SGRIRLNGQDATRV----- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   88 sDLRGAVVSMVFQEprLALDPVYTVGRQIE--ETIMRHEKVSRGLAAERALALFQKvripspERRLSNYPHEMSGGMLQR 165
Cdd:TIGR00968  68 -HARDRKIGFVFQH--YALFKHLTVRDNIAfgLEIRKHPKAKIKARVEELLELVQL------EGLGDRYPNQLSGGQRQR 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  166 AMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDI 245
Cdd:TIGR00968 139 VALARALAVEPQVLLLDEPFGALDAKVRKELRSWLRKLHDEVHVTTVFVTHDQEEAMEVADRIVVMSNGKIEQIGSPDEV 218

                         250
                  ....*....|....*
gi 523689182  246 IRNPRHPYTKGLLGA 260
Cdd:TIGR00968 219 YDHPANPFVMSFLGE 233

PRK14247

phosphate ABC transporter ATP-binding protein; Provisional

7-262

3.54e-39

phosphate ABC transporter ATP-binding protein; Provisional

Pssm-ID: 172735 [Multi-domain] Cd Length: 250 Bit Score: 138.51 E-value: 3.54e-39

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   7 AMIDISNLSVTFrrggKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMR---SLLRLHPKGTlIEGGMTVDGHDIMSLS 83
Cdd:PRK14247   2 NKIEIRDLKVSF----GQVEVLDGVNLEIPDNTITALMGPSGSGKSTLLRvfnRLIELYPEAR-VSGEVYLDGQDIFKMD 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  84 nraLSDLRGAVvSMVFQEPrlalDPVYTVgrQIEETIMRHEKVSRgLAAERAlALFQKVRIP--------SPERRLSNYP 155
Cdd:PRK14247  77 ---VIELRRRV-QMVFQIP----NPIPNL--SIFENVALGLKLNR-LVKSKK-ELQERVRWAlekaqlwdEVKDRLDAPA 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 156 HEMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREygLSVIFVTHDIGVAAEVADRIAVMYAGR 235
Cdd:PRK14247 145 GKLSGGQQQRLCIARALAFQPEVLLADEPTANLDPENTAKIESLFLELKKD--MTIVLVTHFPQQAARISDYVAFLYKGQ 222

                        250       260
                 ....*....|....*....|....*..
gi 523689182 236 IVEEGLVGDIIRNPRHPYTKGLLGARV 262
Cdd:PRK14247 223 IVEWGPTREVFTNPRHELTEKYVTGRL 249

ZnuC

COG1121

ABC-type Mn2+/Zn2+ transport system, ATPase component [Inorganic ion transport and metabolism]; ...

3-247

3.82e-38

ABC-type Mn2+/Zn2+ transport system, ATPase component [Inorganic ion transport and metabolism];

Pssm-ID: 440738 [Multi-domain] Cd Length: 245 Bit Score: 135.60 E-value: 3.82e-38

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   3 MQNDAMIDISNLSVTFRRggkaVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPkgtLIEGGMTVDGHDIMSL 82
Cdd:COG1121    1 MMMMPAIELENLTVSYGG----RPVLEDVSLTIPPGEFVAIVGPNGAGKSTLLKAILGLLP---PTSGTVRLFGKPPRRA 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  83 SNRalsdlrgavVSMVFQepRLALD---PVyTVgrqiEETIM----RHEKVSRGL------AAERALAL-----FQKVRI 144
Cdd:COG1121   74 RRR---------IGYVPQ--RAEVDwdfPI-TV----RDVVLmgryGRRGLFRRPsradreAVDEALERvgledLADRPI 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 145 psperrlsnypHEMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEV 224
Cdd:COG1121  138 -----------GELSGGQQQRVLLARALAQDPDLLLLDEPFAGVDAATEEALYELLRELRRE-GKTILVVTHDLGAVREY 205

                        250       260
                 ....*....|....*....|...
gi 523689182 225 ADRIAVMyAGRIVEEGLVGDIIR 247
Cdd:COG1121  206 FDRVLLL-NRGLVAHGPPEEVLT 227

ABC_tran

pfam00005

ABC transporter; ABC transporters for a large family of proteins responsible for translocation ...

28-186

8.20e-38

Pssm-ID: 394964 [Multi-domain] Cd Length: 150 Bit Score: 131.62 E-value: 8.20e-38

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   28 VNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKgtlIEGGMTVDGHDIMSLSNRALsdlrGAVVSMVFQEPRLalD 107
Cdd:pfam00005   1 LKNVSLTLNPGEILALVGPNGAGKSTLLKLIAGLLSP---TEGTILLDGQDLTDDERKSL----RKEIGYVFQDPQL--F 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  108 PVYTVGRQIEETiMRHEKVSRGLAAERALALFQKVRIPS-PERRLSNYPHEMSGGMLQRAMIAMALACNPKVLLADEPTT 186
Cdd:pfam00005  72 PRLTVRENLRLG-LLLKGLSKREKDARAEEALEKLGLGDlADRPVGERPGTLSGGQRQRVAIARALLTKPKLLLLDEPTA 150

MalK

COG3839

ABC-type sugar transport system, ATPase component MalK [Carbohydrate transport and metabolism]; ...

7-287

9.96e-38

ABC-type sugar transport system, ATPase component MalK [Carbohydrate transport and metabolism];

Pssm-ID: 443050 [Multi-domain] Cd Length: 352 Bit Score: 137.51 E-value: 9.96e-38

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   7 AMIDISNLSVTFrrggKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHpkgTLIEGGMTVDGHDIMSLSNRA 86
Cdd:COG3839    2 ASLELENVSKSY----GGVEALKDIDLDIEDGEFLVLLGPSGCGKSTLLRMIAGLE---DPTSGEILIGGRDVTDLPPKD 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  87 lsdlRGavVSMVFQEPrlALDPVYTVgrqiEETI---MRHEKVSRGLAAERALALFQKVRIpspERRLSNYPHEMSGGML 163
Cdd:COG3839   75 ----RN--IAMVFQSY--ALYPHMTV----YENIafpLKLRKVPKAEIDRRVREAAELLGL---EDLLDRKPKQLSGGQR 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 164 QRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDigvAAEV---ADRIAVMYAGRIVEEG 240
Cdd:COG3839  140 QRVALGRALVREPKVFLLDEPLSNLDAKLRVEMRAEIKRLHRRLGTTTIYVTHD---QVEAmtlADRIAVMNDGRIQQVG 216

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 523689182 241 LVGDIIRNPRHPYTKGLLGA------RVELAEGRDRL--VTIPgAPPDLAAMPPG 287
Cdd:COG3839  217 TPEELYDRPANLFVAGFIGSppmnllPGTVEGGGVRLggVRLP-LPAALAAAAGG 270

heterocyst_DevA

TIGR02982

ABC exporter ATP-binding subunit, DevA family; Members of this protein family are found mostly ...

9-237

3.49e-37

ABC exporter ATP-binding subunit, DevA family; Members of this protein family are found mostly in the Cyanobacteria, but also in the Planctomycetes. Cyanobacterial examples are involved in heterocyst formation, by which some fraction of members of the colony undergo a developmental change and become capable of nitrogen fixation. The DevBCA proteins are thought export of either heterocyst-specific glycolipids or an enzyme essential for formation of the laminated layer found in heterocysts.

Pssm-ID: 274374 [Multi-domain] Cd Length: 220 Bit Score: 132.45 E-value: 3.49e-37

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182    9 IDISNLSVTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSvTMRSL---LRlhpkgTLIEGGMTVDGHDIMSLSNR 85
Cdd:TIGR02982   2 ISIRNLNHYYGHGSLRKQVLFDINLEINPGEIVILTGPSGSGKT-TLLTLiggLR-----SVQEGSLKVLGQELHGASKK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   86 ALSDLRGAVvSMVFQEPRLAldPVYTVGRQIEETIMRHEKVSRGLAAERALALFQKVRIpspERRLSNYPHEMSGGMLQR 165
Cdd:TIGR02982  76 QLVQLRRRI-GYIFQAHNLL--GFLTARQNVQMALELQPNLSYQEARERARAMLEAVGL---GDHLNYYPHNLSGGQKQR 149

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 523689182  166 AMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVaAEVADRIAVMYAGRIV 237
Cdd:TIGR02982 150 VAIARALVHHPKLVLADEPTAALDSKSGRDVVELMQKLAKEQGCTILMVTHDNRI-LDVADRILQMEDGKLL 220

PhnT2

TIGR03265

putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; This ABC transporter ...

24-253

3.78e-37

putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; This ABC transporter ATP-binding protein is found in a number of genomes in operon-like contexts strongly suggesting a substrate specificity for 2-aminoethylphosphonate (2-AEP). The characterized PhnSTUV system is absent in the genomes in which this system is found. These genomes encode systems for the catabolism of 2-AEP, making the need for a 2-AEP-specific transporter likely. [Transport and binding proteins, Amino acids, peptides and amines]

Pssm-ID: 274496 [Multi-domain] Cd Length: 353 Bit Score: 135.93 E-value: 3.78e-37

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   24 AVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHpkgTLIEGGMTVDGHDIMSLSNRAlsdlRGavVSMVFQEpr 103
Cdd:TIGR03265  16 AFTALKDISLSVKKGEFVCLLGPSGCGKTTLLRIIAGLE---RQTAGTIYQGGRDITRLPPQK----RD--YGIVFQS-- 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  104 LALDPVYTVGRQIEETiMRHEKVSRGLAAERALALFQKVRIPSPERRlsnYPHEMSGGMLQRAMIAMALACNPKVLLADE 183
Cdd:TIGR03265  85 YALFPNLTVADNIAYG-LKNRGMGRAEVAERVAELLDLVGLPGSERK---YPGQLSGGQQQRVALARALATSPGLLLLDE 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  184 PTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDIIRNPRHPY 253
Cdd:TIGR03265 161 PLSALDARVREHLRTEIRQLQRRLGVTTIMVTHDQEEALSMADRIVVMNHGVIEQVGTPQEIYRHPATPF 230

ABC_ModC_like

cd03299

ATP-binding cassette domain similar to the molybdate transporter; Archaeal protein closely ...

30-262

7.82e-37

ATP-binding cassette domain similar to the molybdate transporter; Archaeal protein closely related to ModC. ModC is an ABC-type transporter and the ATPase component of a molybdate transport system that also includes the periplasmic binding protein ModA and the membrane protein ModB. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213266 [Multi-domain] Cd Length: 235 Bit Score: 132.07 E-value: 7.82e-37

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  30 GVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKgtlIEGGMTVDGHDIMSLSnralSDLRGavVSMVFQEprLALDPV 109
Cdd:cd03299   17 NVSLEVERGDYFVILGPTGSGKSVLLETIAGFIKP---DSGKILLNGKDITNLP----PEKRD--ISYVPQN--YALFPH 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 110 YTVGRQIEETiMRHEKVSRGLAAERALALFQKVRIpspERRLSNYPHEMSGGMLQRAMIAMALACNPKVLLADEPTTALD 189
Cdd:cd03299   86 MTVYKNIAYG-LKKRKVDKKEIERKVLEIAEMLGI---DHLLNRKPETLSGGEQQRVAIARALVVNPKILLLDEPFSALD 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 523689182 190 ATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDIIRNPRHPYTKGLLGARV 262
Cdd:cd03299  162 VRTKEKLREELKKIRKEFGVTVLHVTHDFEEAWALADKVAIMLNGKLIQVGKPEEVFKKPKNEFVAEFLGFNN 234

ABC_DrrA

cd03265

Daunorubicin/doxorubicin resistance ATP-binding protein; DrrA is the ATP-binding protein ...

9-245

9.18e-37

Daunorubicin/doxorubicin resistance ATP-binding protein; DrrA is the ATP-binding protein component of a bacterial exporter complex that confers resistance to the antibiotics daunorubicin and doxorubicin. In addition to DrrA, the complex includes an integral membrane protein called DrrB. DrrA belongs to the ABC family of transporters and shares sequence and functional similarities with a protein found in cancer cells called P-glycoprotein. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region in addition to the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213232 [Multi-domain] Cd Length: 220 Bit Score: 131.34 E-value: 9.18e-37

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLsvTFRRGGkaVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGTlieGGMTVDGHDIMslsnRALS 88
Cdd:cd03265    1 IEVENL--VKKYGD--FEAVRGVSFRVRRGEIFGLLGPNGAGKTTTIKMLTTLLKPTS---GRATVAGHDVV----REPR 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  89 DLRgAVVSMVFQEPrlALDPVYTvGRQIEETIMRHEKVSRGLAAERALALFQKVRI-PSPERRLSNYphemSGGMLQRAM 167
Cdd:cd03265   70 EVR-RRIGIVFQDL--SVDDELT-GWENLYIHARLYGVPGAERRERIDELLDFVGLlEAADRLVKTY----SGGMRRRLE 141

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 523689182 168 IAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDI 245
Cdd:cd03265  142 IARSLVHRPEVLFLDEPTIGLDPQTRAHVWEYIEKLKEEFGMTILLTTHYMEEAEQLCDRVAIIDHGRIIAEGTPEEL 219

FetA

COG4619

ABC-type iron transporter FetAB, ATPase component [Inorganic ion transport and metabolism];

16-236

1.17e-36

ABC-type iron transporter FetAB, ATPase component [Inorganic ion transport and metabolism];

Pssm-ID: 443661 [Multi-domain] Cd Length: 209 Bit Score: 130.71 E-value: 1.17e-36

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  16 VTFRRGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGtliEGGMTVDGHDIMSLSnraLSDLRGAVv 95
Cdd:COG4619    6 LSFRVGGKPI--LSPVSLTLEAGECVAITGPSGSGKSTLLRALADLDPPT---SGEIYLDGKPLSAMP---PPEWRRQV- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  96 SMVFQEPRLALDpvyTVGRQIEET-IMRHEKVSRglaaERALALFQKVRIPspERRLSNYPHEMSGGMLQRAMIAMALAC 174
Cdd:COG4619   77 AYVPQEPALWGG---TVRDNLPFPfQLRERKFDR----ERALELLERLGLP--PDILDKPVERLSGGERQRLALIRALLL 147

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 523689182 175 NPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRI 236
Cdd:COG4619  148 QPDVLLLDEPTSALDPENTRRVEELLREYLAEEGRAVLWVSHDPEQIERVADRVLTLEAGRL 209

PhnL

COG4778

Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnL [Inorganic ion ...

7-235

2.81e-36

Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnL [Inorganic ion transport and metabolism];

Pssm-ID: 443809 [Multi-domain] Cd Length: 229 Bit Score: 130.25 E-value: 2.81e-36

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   7 AMIDISNLSVTFR---RGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLR--LHPKGTLI---EGGMTvdghD 78
Cdd:COG4778    3 TLLEVENLSKTFTlhlQGGKRLPVLDGVSFSVAAGECVALTGPSGAGKSTLLKCIYGnyLPDSGSILvrhDGGWV----D 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  79 IMSLSNRALSDLRGAVVSMVFQ----EPRL-ALDPVytvgrqIEEtiMRHEKVSRGLAAERALALFQKVRIPspERRLSN 153
Cdd:COG4778   79 LAQASPREILALRRRTIGYVSQflrvIPRVsALDVV------AEP--LLERGVDREEARARARELLARLNLP--ERLWDL 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 154 YPHEMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYA 233
Cdd:COG4778  149 PPATFSGGEQQRVNIARGFIADPPLLLLDEPTASLDAANRAVVVELIEEAKAR-GTAIIGIFHDEEVREAVADRVVDVTP 227


                 ..
gi 523689182 234 GR 235
Cdd:COG4778  228 FS 229

ArtP

COG4161

ABC-type arginine transport system, ATPase component [Amino acid transport and metabolism];

27-240

3.20e-36

ABC-type arginine transport system, ATPase component [Amino acid transport and metabolism];

Pssm-ID: 443326 [Multi-domain] Cd Length: 242 Bit Score: 130.52 E-value: 3.20e-36

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  27 AVNGVSLSVKPGEVVALLGESGSGKSVTMR--SLLRLHPKGTLIEGGMTVDGHDimSLSNRALSDLRGAVvSMVFQEPRL 104
Cdd:COG4161   17 ALFDINLECPSGETLVLLGPSGAGKSSLLRvlNLLETPDSGQLNIAGHQFDFSQ--KPSEKAIRLLRQKV-GMVFQQYNL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 105 AldPVYTVGRQIEETIMRHEKVSRGLAAERALALFQKVRIPSPERRlsnYPHEMSGGMLQRAMIAMALACNPKVLLADEP 184
Cdd:COG4161   94 W--PHLTVMENLIEAPCKVLGLSKEQAREKAMKLLARLRLTDKADR---FPLHLSGGQQQRVAIARALMMEPQVLLFDEP 168

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 523689182 185 TTALDATVQIQILLLIRELQrEYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEG 240
Cdd:COG4161  169 TAALDPEITAQVVEIIRELS-QTGITQVIVTHEVEFARKVASQVVYMEKGRIIEQG 223

artP

PRK11124

arginine transporter ATP-binding subunit; Provisional

31-240

3.51e-36

arginine transporter ATP-binding subunit; Provisional

Pssm-ID: 182980 [Multi-domain] Cd Length: 242 Bit Score: 130.52 E-value: 3.51e-36

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  31 VSLSVKPGEVVALLGESGSGKSVTMR--SLLRLHPKGTLIEGGMTVDghdimsLSN----RALSDLRGAVvSMVFQEPRL 104
Cdd:PRK11124  21 ITLDCPQGETLVLLGPSGAGKSSLLRvlNLLEMPRSGTLNIAGNHFD------FSKtpsdKAIRELRRNV-GMVFQQYNL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 105 AldPVYTVGRQIEETIMRHEKVSRGLAAERALALFQKVRI-PSPERrlsnYPHEMSGGMLQRAMIAMALACNPKVLLADE 183
Cdd:PRK11124  94 W--PHLTVQQNLIEAPCRVLGLSKDQALARAEKLLERLRLkPYADR----FPLHLSGGQQQRVAIARALMMEPQVLLFDE 167

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 523689182 184 PTTALDATVQIQILLLIRELQrEYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEG 240
Cdd:PRK11124 168 PTAALDPEITAQIVSIIRELA-ETGITQVIVTHEVEVARKTASRVVYMENGHIVEQG 223

ABC_Mj1267_LivG_branched

cd03219

ATP-binding cassette component of branched chain amino acids transport system; The Mj1267/LivG ...

9-250

3.51e-36

ATP-binding cassette component of branched chain amino acids transport system; The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E. coli branched-chain amino acid transporter. MJ1267 contains an insertion from residues 114 to 123 characteristic of LivG (Leucine-Isoleucine-Valine) homologs. The branched-chain amino acid transporter from E. coli comprises a heterodimer of ABCs (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ).

Pssm-ID: 213186 [Multi-domain] Cd Length: 236 Bit Score: 130.25 E-value: 3.51e-36

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTFrrGGkaVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHP--KGTLIeggmtVDGHDIMSLSNRA 86
Cdd:cd03219    1 LEVRGLTKRF--GG--LVALDDVSFSVRPGEIHGLIGPNGAGKTTLFNLISGFLRptSGSVL-----FDGEDITGLPPHE 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  87 LSDLRgavVSMVFQEPRL-----ALDPVYTVGRQIEETIMRHEKVSRGLAA--ERALALFQKVRIpspERRLSNYPHEMS 159
Cdd:cd03219   72 IARLG---IGRTFQIPRLfpeltVLENVMVAAQARTGSGLLLARARREEREarERAEELLERVGL---ADLADRPAGELS 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 160 GGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELqREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEE 239
Cdd:cd03219  146 YGQQRRLEIARALATDPKLLLLDEPAAGLNPEETEELAELIREL-RERGITVLLVEHDMDVVMSLADRVTVLDQGRVIAE 224

                        250
                 ....*....|.
gi 523689182 240 GLVGDIIRNPR 250
Cdd:cd03219  225 GTPDEVRNNPR 235

PRK15112

peptide ABC transporter ATP-binding protein SapF;

6-258

1.26e-35

peptide ABC transporter ATP-binding protein SapF;

Pssm-ID: 185067 [Multi-domain] Cd Length: 267 Bit Score: 129.91 E-value: 1.26e-35

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   6 DAMIDISNLSVTFR-RGG----KAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGTlieGGMTVDGHDIm 80
Cdd:PRK15112   2 ETLLEVRNLSKTFRyRTGwfrrQTVEAVKPLSFTLREGQTLAIIGENGSGKSTLAKMLAGMIEPTS---GELLIDDHPL- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  81 slsnrALSD--LRGAVVSMVFQEPRLALDPVYTVGRQIEETIMRHEKVSrglAAERALALFQKVRIPS--PERrLSNYPH 156
Cdd:PRK15112  78 -----HFGDysYRSQRIRMIFQDPSTSLNPRQRISQILDFPLRLNTDLE---PEQREKQIIETLRQVGllPDH-ASYYPH 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 157 EMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRI 236
Cdd:PRK15112 149 MLAPGQKQRLGLARALILRPKVIIADEALASLDMSMRSQLINLMLELQEKQGISYIYVTQHLGMMKHISDQVLVMHQGEV 228

                        250       260
                 ....*....|....*....|..
gi 523689182 237 VEEGLVGDIIRNPRHPYTKGLL 258
Cdd:PRK15112 229 VERGSTADVLASPLHELTKRLI 250

PRK10851

sulfate/thiosulfate ABC transporter ATP-binding protein CysA;

9-249

1.99e-35

sulfate/thiosulfate ABC transporter ATP-binding protein CysA;

Pssm-ID: 182778 [Multi-domain] Cd Length: 353 Bit Score: 131.36 E-value: 1.99e-35

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTFRRggkaVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGtliEGGMTVDGHDIMSLSNRals 88
Cdd:PRK10851   3 IEIANIKKSFGR----TQVLNDISLDIPSGQMVALLGPSGSGKTTLLRIIAGLEHQT---SGHIRFHGTDVSRLHAR--- 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  89 DLRgavVSMVFQEprLALDPVYTVGRQIE---ETIMRHEKVSRGLAAERALALFQKVRIPsperRLSN-YPHEMSGGMLQ 164
Cdd:PRK10851  73 DRK---VGFVFQH--YALFRHMTVFDNIAfglTVLPRRERPNAAAIKAKVTQLLEMVQLA----HLADrYPAQLSGGQKQ 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 165 RAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGD 244
Cdd:PRK10851 144 RVALARALAVEPQILLLDEPFGALDAQVRKELRRWLRQLHEELKFTSVFVTHDQEEAMEVADRVVVMSQGNIEQAGTPDQ 223


                 ....*
gi 523689182 245 IIRNP 249
Cdd:PRK10851 224 VWREP 228

ABC_ATPase

cd00267

ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large ...

11-235

3.42e-35

ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213179 [Multi-domain] Cd Length: 157 Bit Score: 125.05 E-value: 3.42e-35

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  11 ISNLSVTFrrggKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGtliEGGMTVDGHDIMSLSNRALSDL 90
Cdd:cd00267    2 IENLSFRY----GGRTALDNVSLTLKAGEIVALVGPNGSGKSTLLRAIAGLLKPT---SGEILIDGKDIAKLPLEELRRR 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  91 rgavVSMVFQeprlaldpvytvgrqieetimrhekvsrglaaeralalfqkvripsperrlsnypheMSGGMLQRAMIAM 170
Cdd:cd00267   75 ----IGYVPQ---------------------------------------------------------LSGGQRQRVALAR 93

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 523689182 171 ALACNPKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAGR 235
Cdd:cd00267   94 ALLLNPDLLLLDEPTSGLDPASRERLLELLRELAEE-GRTVIIVTHDPELAELAADRVIVLKDGK 157

ABC_MalK_N

cd03301

The N-terminal ATPase domain of the maltose transporter, MalK; ATP binding cassette (ABC) ...

25-240

4.10e-35

The N-terminal ATPase domain of the maltose transporter, MalK; ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two transmembrane-spanning domains (TMDs) or subunits and two nucleotide binding domains (NBDs) or subunits that couple transport to the hydrolysis of ATP. In the maltose transport system, the periplasmic maltose binding protein (MBP) stimulates the ATPase activity of the membrane-associated transporter, which consists of two transmembrane subunits, MalF and MalG, and two copies of the ATP binding subunit, MalK, and becomes tightly bound to the transporter in the catalytic transition state, ensuring that maltose is passed to the transporter as ATP is hydrolyzed.

Pssm-ID: 213268 [Multi-domain] Cd Length: 213 Bit Score: 126.60 E-value: 4.10e-35

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  25 VKAVNGVSLSVKPGEVVALLGESGSGKSVTMRsllrlhpkgtLIEGGMTVDGHDImSLSNRALSDL----RGavVSMVFQ 100
Cdd:cd03301   13 VTALDDLNLDIADGEFVVLLGPSGCGKTTTLR----------MIAGLEEPTSGRI-YIGGRDVTDLppkdRD--IAMVFQ 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 101 EprLALDPVYTVGRQIEETiMRHEKVSRGLAAERALALFQKVRIpspERRLSNYPHEMSGGMLQRAMIAMALACNPKVLL 180
Cdd:cd03301   80 N--YALYPHMTVYDNIAFG-LKLRKVPKDEIDERVREVAELLQI---EHLLDRKPKQLSGGQRQRVALGRAIVREPKVFL 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 181 ADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEG 240
Cdd:cd03301  154 MDEPLSNLDAKLRVQMRAELKRLQQRLGTTTIYVTHDQVEAMTMADRIAVMNDGQIQQIG 213

ABC_subfamily_A

cd03263

ATP-binding cassette domain of the lipid transporters, subfamily A; The ABCA subfamily ...

9-240

8.11e-35

ATP-binding cassette domain of the lipid transporters, subfamily A; The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency, degenerative retinopathies, and congenital keratinization disorders. The ABCA1 protein is involved in disorders of cholesterol transport and high-density lipoprotein (HDL) biosynthesis. The ABCA4 (ABCR) protein transports vitamin A derivatives in the outer segments of photoreceptor cells, and therefore, performs a crucial step in the visual cycle. The ABCA genes are not present in yeast. However, evolutionary studies of ABCA genes indicate that they arose as transporters that subsequently duplicated and that certain sets of ABCA genes were lost in different eukaryotic lineages.

Pssm-ID: 213230 [Multi-domain] Cd Length: 220 Bit Score: 126.08 E-value: 8.11e-35

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTFRRGGKavKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGTlieGGMTVDGHDIMSLSNRALS 88
Cdd:cd03263    1 LQIRNLTKTYKKGTK--PAVDDLSLNVYKGEIFGLLGHNGAGKTTTLKMLTGELRPTS---GTAYINGYSIRTDRKAARQ 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  89 dlrgaVVSMVFQEprLALDPVYTVgrqiEETIMRHEKVsRGL----AAERALALFQKVRIPSPERRLSnypHEMSGGMLQ 164
Cdd:cd03263   76 -----SLGYCPQF--DALFDELTV----REHLRFYARL-KGLpkseIKEEVELLLRVLGLTDKANKRA---RTLSGGMKR 140

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 523689182 165 RAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQReyGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEG 240
Cdd:cd03263  141 KLSLAIALIGGPSVLLLDEPTSGLDPASRRAIWDLILEVRK--GRSIILTTHSMDEAEALCDRIAIMSDGKLRCIG 214

hmuV

PRK13548

hemin importer ATP-binding subunit; Provisional

7-240

1.36e-34

hemin importer ATP-binding subunit; Provisional

Pssm-ID: 237422 [Multi-domain] Cd Length: 258 Bit Score: 126.81 E-value: 1.36e-34

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   7 AMIDISNLSVtfRRGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSVTMRSLL-RLHPkgtlIEGGMTVDGHDIMSLSNR 85
Cdd:PRK13548   1 AMLEARNLSV--RLGGRTL--LDDVSLTLRPGEVVAILGPNGAGKSTLLRALSgELSP----DSGEVRLNGRPLADWSPA 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  86 ALSDLRgAVVSmvfQEPRLALDpvYTVgrqieetimrHEKVSRGLA------------AERALALfqkVRIPSPERRLsn 153
Cdd:PRK13548  73 ELARRR-AVLP---QHSSLSFP--FTV----------EEVVAMGRAphglsraeddalVAAALAQ---VDLAHLAGRD-- 131

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 154 YPhEMSGGMLQRAMIAMALA------CNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADR 227
Cdd:PRK13548 132 YP-QLSGGEQQRVQLARVLAqlwepdGPPRWLLLDEPTSALDLAHQHHVLRLARQLAHERGLAVIVVLHDLNLAARYADR 210

                        250
                 ....*....|...
gi 523689182 228 IAVMYAGRIVEEG 240
Cdd:PRK13548 211 IVLLHQGRLVADG 223

CeuD

COG4604

ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and ...

8-247

1.61e-34

ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism];

Pssm-ID: 443654 [Multi-domain] Cd Length: 252 Bit Score: 126.35 E-value: 1.61e-34

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSVTFrrGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSvTMRSLL-RLHPKGtliEGGMTVDGHDIMSLSNRA 86
Cdd:COG4604    1 MIEIKNVSKRY--GGKVV--LDDVSLTIPKGGITALIGPNGAGKS-TLLSMIsRLLPPD---SGEVLVDGLDVATTPSRE 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  87 LSdlrgAVVSMVFQEPRLAL-----DPV------YTVGRQIEETimrHEKVsrglaaERALALFQkvripsperrLSNYP 155
Cdd:COG4604   73 LA----KRLAILRQENHINSrltvrELVafgrfpYSKGRLTAED---REII------DEAIAYLD----------LEDLA 129

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 156 H----EMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVM 231
Cdd:COG4604  130 DryldELSGGQRQRAFIAMVLAQDTDYVLLDEPLNNLDMKHSVQMMKLLRRLADELGKTVVIVLHDINFASCYADHIVAM 209

                        250
                 ....*....|....*.
gi 523689182 232 YAGRIVEEGLVGDIIR 247
Cdd:COG4604  210 KDGRVVAQGTPEEIIT 225

MglA

COG1129

ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism];

5-245

1.95e-34

ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism];

Pssm-ID: 440745 [Multi-domain] Cd Length: 497 Bit Score: 131.29 E-value: 1.95e-34

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   5 NDAMIDISNLSVTFrrGGkaVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGtliEGGMTVDGHDIMSLSN 84
Cdd:COG1129    1 AEPLLEMRGISKSF--GG--VKALDGVSLELRPGEVHALLGENGAGKSTLMKILSGVYQPD---SGEILLDGEPVRFRSP 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  85 RalsDLRGAVVSMVFQEPRLALDpvytvgRQIEETI-MRHEKVSRGL-----AAERALALFQKVRIP-SPERRLSNYPhe 157
Cdd:COG1129   74 R---DAQAAGIAIIHQELNLVPN------LSVAENIfLGREPRRGGLidwraMRRRARELLARLGLDiDPDTPVGDLS-- 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 158 msggMLQRAM--IAMALACNPKVLLADEPTTALDATvQIQILL-LIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAG 234
Cdd:COG1129  143 ----VAQQQLveIARALSRDARVLILDEPTASLTER-EVERLFrIIRRLKAQ-GVAIIYISHRLDEVFEIADRVTVLRDG 216

                        250
                 ....*....|.
gi 523689182 235 RIVEEGLVGDI 245
Cdd:COG1129  217 RLVGTGPVAEL 227

cbiO

PRK13635

energy-coupling factor ABC transporter ATP-binding protein;

16-240

5.56e-34

energy-coupling factor ABC transporter ATP-binding protein;

Pssm-ID: 184195 [Multi-domain] Cd Length: 279 Bit Score: 125.51 E-value: 5.56e-34

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  16 VTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLlrlhpKGTLI--EGGMTVDGhdiMSLSNRALSDLRgA 93
Cdd:PRK13635  11 ISFRYPDAATYALKDVSFSVYEGEWVAIVGHNGSGKSTLAKLL-----NGLLLpeAGTITVGG---MVLSEETVWDVR-R 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  94 VVSMVFQEPrlalDPVYtVGRQIEETI---MRHEKVSRGLAAERALALFQKVRIpspERRLSNYPHEMSGGMLQRAMIAM 170
Cdd:PRK13635  82 QVGMVFQNP----DNQF-VGATVQDDVafgLENIGVPREEMVERVDQALRQVGM---EDFLNREPHRLSGGQKQRVAIAG 153

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 171 ALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEvADRIAVMYAGRIVEEG 240
Cdd:PRK13635 154 VLALQPDIIILDEATSMLDPRGRREVLETVRQLKEQKGITVLSITHDLDEAAQ-ADRVIVMNKGEILEEG 222

SunT

COG2274

ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase ...

9-240

1.79e-33

ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms];

Pssm-ID: 441875 [Multi-domain] Cd Length: 711 Bit Score: 129.95 E-value: 1.79e-33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNlsVTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPkgtLIEGGMTVDGHDIMSLSnraLS 88
Cdd:COG2274  474 IELEN--VSFRYPGDSPPVLDNISLTIKPGERVAIVGRSGSGKSTLLKLLLGLYE---PTSGRILIDGIDLRQID---PA 545

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  89 DLRGAvVSMVFQEPRL---------AL-DPVYTVGR--------QIEETIMRHEKvsrGLA---AERALALfqkvripsp 147
Cdd:COG2274  546 SLRRQ-IGVVLQDVFLfsgtireniTLgDPDATDEEiieaarlaGLHDFIEALPM---GYDtvvGEGGSNL--------- 612

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 148 errlsnyphemSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQReyGLSVIFVTHDIGVAAEvADR 227
Cdd:COG2274  613 -----------SGGQRQRLAIARALLRNPRILILDEATSALDAETEAIILENLRRLLK--GRTVIIIAHRLSTIRL-ADR 678

                        250
                 ....*....|...
gi 523689182 228 IAVMYAGRIVEEG 240
Cdd:COG2274  679 IIVLDKGRIVEDG 691

cbiO

PRK13637

energy-coupling factor transporter ATPase;

9-248

2.04e-33

energy-coupling factor transporter ATPase;

Pssm-ID: 237455 [Multi-domain] Cd Length: 287 Bit Score: 124.39 E-value: 2.04e-33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTFRRGGK-AVKAVNGVSLSVKPGEVVALLGESGSGKSVtmrslLRLHPKGTL--IEGGMTVDGHDIMSlSNR 85
Cdd:PRK13637   3 IKIENLTHIYMEGTPfEKKALDNVNIEIEDGEFVGLIGHTGSGKST-----LIQHLNGLLkpTSGKIIIDGVDITD-KKV 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  86 ALSDLRGAVvSMVFQEPRLALdpvytvgrqIEETImrhEK------VSRGLAAE----RALALFQKVRIpSPERRLSNYP 155
Cdd:PRK13637  77 KLSDIRKKV-GLVFQYPEYQL---------FEETI---EKdiafgpINLGLSEEeienRVKRAMNIVGL-DYEDYKDKSP 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 156 HEMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGR 235
Cdd:PRK13637 143 FELSGGQKRRVAIAGVVAMEPKILILDEPTAGLDPKGRDEILNKIKELHKEYNMTIILVSHSMEDVAKLADRIIVMNKGK 222

                        250
                 ....*....|...
gi 523689182 236 IVEEGLVGDIIRN 248
Cdd:PRK13637 223 CELQGTPREVFKE 235

ABC_Metallic_Cations

cd03235

ATP-binding cassette domain of the metal-type transporters; This family includes transporters ...

11-231

7.33e-33

ATP-binding cassette domain of the metal-type transporters; This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-siderophore uptake family suggesting that they share a common ancestor. The best characterized metal-type ABC transporters are the YfeABCD system of Y. pestis, the SitABCD system of Salmonella enterica serovar Typhimurium, and the SitABCD transporter of Shigella flexneri. Moreover other uncharacterized homologs of these metal-type transporters are mainly found in pathogens like Haemophilus or enteroinvasive E. coli isolates.

Pssm-ID: 213202 [Multi-domain] Cd Length: 213 Bit Score: 120.72 E-value: 7.33e-33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  11 ISNLSVTFRRggkaVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKgtlIEGGMTVDGHDIMSLSNRalsdl 90
Cdd:cd03235    2 VEDLTVSYGG----HPVLEDVSFEVKPGEFLAIVGPNGAGKSTLLKAILGLLKP---TSGSIRVFGKPLEKERKR----- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  91 rgavVSMVFQepRLALDPVYTVgrQIEETIM----RHEKVSRGLAAE---RALALFQKVRIPS-PERRLSnyphEMSGGM 162
Cdd:cd03235   70 ----IGYVPQ--RRSIDRDFPI--SVRDVVLmglyGHKGLFRRLSKAdkaKVDEALERVGLSElADRQIG----ELSGGQ 137

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 523689182 163 LQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVM 231
Cdd:cd03235  138 QQRVLLARALVQDPDLLLLDEPFAGVDPKTQEDIYELLRELRRE-GMTILVVTHDLGLVLEYFDRVLLL 205

ABC_NatA_sodium_exporter

cd03266

ATP-binding cassette domain of the Na+ transporter; NatA is the ATPase component of a ...

8-240

5.94e-32

ATP-binding cassette domain of the Na+ transporter; NatA is the ATPase component of a bacterial ABC-type Na+ transport system called NatAB, which catalyzes ATP-dependent electrogenic Na+ extrusion without mechanically coupled proton or K+ uptake. NatB possess six putative membrane spanning regions at its C-terminus. In B. subtilis, NatAB is inducible by agents such as ethanol and protonophores, which lower the proton-motive force across the membrane. The closest sequence similarity to NatA is exhibited by DrrA of the two-component daunorubicin- and doxorubicin-efflux system. Hence, the functional NatAB is presumably assembled with two copies of a single ATP-binding protein and a single integral membrane protein.

Pssm-ID: 213233 [Multi-domain] Cd Length: 218 Bit Score: 118.62 E-value: 5.94e-32

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSVTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLrlhpkgTLIE---GGMTVDGHDimslsn 84
Cdd:cd03266    1 MITADALTKRFRDVKKTVQAVDGVSFTVKPGEVTGLLGPNGAGKTTTLRMLA------GLLEpdaGFATVDGFD------ 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  85 rALSDLRGAVVSMVFQEPRLALDPVYTVGRQIEETIMRHekvsrGLAAERALA----LFQKVRI-PSPERRLSnyphEMS 159
Cdd:cd03266   69 -VVKEPAEARRRLGFVSDSTGLYDRLTARENLEYFAGLY-----GLKGDELTArleeLADRLGMeELLDRRVG----GFS 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 160 GGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELqREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEE 239
Cdd:cd03266  139 TGMRQKVAIARALVHDPPVLLLDEPTTGLDVMATRALREFIRQL-RALGKCILFSTHIMQEVERLCDRVVVLHRGRVVYE 217


                 .
gi 523689182 240 G 240
Cdd:cd03266  218 G 218

ABCC_MRP_Like

cd03228

ATP-binding cassette domain of multidrug resistance protein-like transporters; The MRP ...

16-235

1.44e-31

ATP-binding cassette domain of multidrug resistance protein-like transporters; The MRP (Multidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a diverse functional spectrum that includes ion transport, cell surface receptor, and toxin secretion activities. The MRP-like family, similar to all ABC proteins, have a common four-domain core structure constituted by two membrane-spanning domains, each composed of six transmembrane (TM) helices, and two nucleotide-binding domains (NBD). ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213195 [Multi-domain] Cd Length: 171 Bit Score: 115.94 E-value: 1.44e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  16 VTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLH-PKgtliEGGMTVDGHDIMSLSnraLSDLRGAv 94
Cdd:cd03228    6 VSFSYPGRPKPVLKDVSLTIKPGEKVAIVGPSGSGKSTLLKLLLRLYdPT----SGEILIDGVDLRDLD---LESLRKN- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  95 VSMVFQEPRLaldpvytVGRQIEETImrhekvsrglaaeralalfqkvripsperrlsnypheMSGGMLQRAMIAMALAC 174
Cdd:cd03228   78 IAYVPQDPFL-------FSGTIRENI-------------------------------------LSGGQRQRIAIARALLR 113

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 523689182 175 NPKVLLADEPTTALDATVQIQILLLIRELQReyGLSVIFVTHDIGvAAEVADRIAVMYAGR 235
Cdd:cd03228  114 DPPILILDEATSALDPETEALILEALRALAK--GKTVIVIAHRLS-TIRDADRIIVLDDGR 171

PRK14239

phosphate transporter ATP-binding protein; Provisional

6-254

1.52e-31

phosphate transporter ATP-binding protein; Provisional

Pssm-ID: 184585 [Multi-domain] Cd Length: 252 Bit Score: 118.34 E-value: 1.52e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   6 DAMIDISNLSVTFRRGgkavKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLR---LHPKGTlIEGGMTVDGHDIMSL 82
Cdd:PRK14239   3 EPILQVSDLSVYYNKK----KALNSVSLDFYPNEITALIGPSGSGKSTLLRSINRmndLNPEVT-ITGSIVYNGHNIYSP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  83 SNRALsDLRGAVvSMVFQEPRLALDPVY---TVGRQIEETimrHEKVSRGLAAERAL---ALFQKVRipspeRRLSNYPH 156
Cdd:PRK14239  78 RTDTV-DLRKEI-GMVFQQPNPFPMSIYenvVYGLRLKGI---KDKQVLDEAVEKSLkgaSIWDEVK-----DRLHDSAL 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 157 EMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYglSVIFVTHDIGVAAEVADRIAVMYAGRI 236
Cdd:PRK14239 148 GLSGGQQQRVCIARVLATSPKIILLDEPTSALDPISAGKIEETLLGLKDDY--TMLLVTRSMQQASRISDRTGFFLDGDL 225

                        250
                 ....*....|....*...
gi 523689182 237 VEEGLVGDIIRNPRHPYT 254
Cdd:PRK14239 226 IEYNDTKQMFMNPKHKET 243

oligo_HPY

TIGR01727

oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; This model ...

235-321

1.69e-31

oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; This model represents a domain found in the C-terminal regions of oligopeptide ABC transporter ATP binding proteins, immediately following the ATP-binding domain (pfam00005). All characterized members appear able to be involved in the transport of oligopeptides or dipeptides. Some are important for sporulation or antibiotic resistance. Some dipeptide transporters also act on the heme precursor delta-aminolevulinic acid. [Transport and binding proteins, Amino acids, peptides and amines]

Pssm-ID: 213647 [Multi-domain] Cd Length: 87 Bit Score: 113.23 E-value: 1.69e-31

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  235 RIVEEGLVGDIIRNPRHPYTKGLLGARVELAEGRDRLVTIPGAPPDLAAMPPGCAFAPRCVQVSDLCQKQIPPLLPLSGG 314
Cdd:TIGR01727   1 KIVETGPAEEIFKNPLHPYTKALLSAIPTIKKRDRKLISIPGEVPSLINLPSGCRFYPRCPYAQDECRKEPPALVEIAEG 80


                  ....*..
gi 523689182  315 AGVACLF 321
Cdd:TIGR01727  81 HRVACHL 87

PRK10070

proline/glycine betaine ABC transporter ATP-binding protein ProV;

27-255

2.48e-31

proline/glycine betaine ABC transporter ATP-binding protein ProV;

Pssm-ID: 182221 [Multi-domain] Cd Length: 400 Bit Score: 121.29 E-value: 2.48e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  27 AVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKgtlIEGGMTVDGHDIMSLSNRALSDLRGAVVSMVFQEprLAL 106
Cdd:PRK10070  43 GVKDASLAIEEGEIFVIMGLSGSGKSTMVRLLNRLIEP---TRGQVLIDGVDIAKISDAELREVRRKKIAMVFQS--FAL 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 107 DPVYTVgrqIEETIMRHEkVSRGLAAERALALFQKVRIPSPERRLSNYPHEMSGGMLQRAMIAMALACNPKVLLADEPTT 186
Cdd:PRK10070 118 MPHMTV---LDNTAFGME-LAGINAEERREKALDALRQVGLENYAHSYPDELSGGMRQRVGLARALAINPDILLMDEAFS 193

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 523689182 187 ALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDIIRNPRHPYTK 255
Cdd:PRK10070 194 ALDPLIRTEMQDELVKLQAKHQRTIVFISHDLDEAMRIGDRIAIMQNGEVVQVGTPDEILNNPANDYVR 262

TauB

COG4525

ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism];

7-238

4.03e-31

ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism];

Pssm-ID: 443596 [Multi-domain] Cd Length: 262 Bit Score: 117.66 E-value: 4.03e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   7 AMIDISNLSVTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSvtmrSLLrlhpkgTLIEGGMTVDGHDIMsLSNRA 86
Cdd:COG4525    2 SMLTVRHVSVRYPGGGQPQPALQDVSLTIESGEFVVALGASGCGKT----TLL------NLIAGFLAPSSGEIT-LDGVP 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  87 LSDlRGAVVSMVFQEPrlALDPVYTVGRQIEETiMRHEKVSRGLAAERALALFQKVRIPSPERRlsnYPHEMSGGMLQRA 166
Cdd:COG4525   71 VTG-PGADRGVVFQKD--ALLPWLNVLDNVAFG-LRLRGVPKAERRARAEELLALVGLADFARR---RIWQLSGGMRQRV 143

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 523689182 167 MIAMALACNPKVLLADEPTTALDATV--QIQILLLirELQREYGLSVIFVTHDIGVAAEVADRIAVM--YAGRIVE 238
Cdd:COG4525  144 GIARALAADPRFLLMDEPFGALDALTreQMQELLL--DVWQRTGKGVFLITHSVEEALFLATRLVVMspGPGRIVE 217

PRK10619

histidine ABC transporter ATP-binding protein HisP;

26-252

5.88e-31

histidine ABC transporter ATP-binding protein HisP;

Pssm-ID: 182592 [Multi-domain] Cd Length: 257 Bit Score: 116.99 E-value: 5.88e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  26 KAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGtliEGGMTVDGHDI---------MSLSNRALSDLRGAVVS 96
Cdd:PRK10619  19 EVLKGVSLQANAGDVISIIGSSGSGKSTFLRCINFLEKPS---EGSIVVNGQTInlvrdkdgqLKVADKNQLRLLRTRLT 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  97 MVFQEprLALDPVYTVGRQIEETIMRHEKVSRGLAAERALALFQKVRIPspERRLSNYPHEMSGGMLQRAMIAMALACNP 176
Cdd:PRK10619  96 MVFQH--FNLWSHMTVLENVMEAPIQVLGLSKQEARERAVKYLAKVGID--ERAQGKYPVHLSGGQQQRVSIARALAMEP 171

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 523689182 177 KVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDIIRNPRHP 252
Cdd:PRK10619 172 EVLLFDEPTSALDPELVGEVLRIMQQLAEE-GKTMVVVTHEMGFARHVSSHVIFLHQGKIEEEGAPEQLFGNPQSP 246

drrA

TIGR01188

daunorubicin resistance ABC transporter ATP-binding subunit; This model describes daunorubicin ...

26-269

1.36e-30

daunorubicin resistance ABC transporter ATP-binding subunit; This model describes daunorubicin resistance ABC transporter, ATP binding subunit in bacteria and archaea. This model is restricted in its scope to preferentially recognize the ATP binding subunit associated with effux of the drug, daunorubicin. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. In eukaryotes proteins of similar function include p-gyco proteins, multidrug resistance protein etc. [Transport and binding proteins, Other]

Pssm-ID: 130256 [Multi-domain] Cd Length: 302 Bit Score: 117.11 E-value: 1.36e-30

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   26 KAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLlrlhpkGTLI---EGGMTVDGHDIMslsnRALSDLRgAVVSMVFQEP 102
Cdd:TIGR01188   7 KAVDGVNFKVREGEVFGFLGPNGAGKTTTIRML------TTLLrptSGTARVAGYDVV----REPRKVR-RSIGIVPQYA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  103 rlALDPVYTvGRQIEETIMRHEKVSRGLAAERALALFQKVRIPSPERRLSNYpheMSGGMLQRAMIAMALACNPKVLLAD 182
Cdd:TIGR01188  76 --SVDEDLT-GRENLEMMGRLYGLPKDEAEERAEELLELFELGEAADRPVGT---YSGGMRRRLDIAASLIHQPDVLFLD 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  183 EPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDIirnprhpytKGLLGARV 262
Cdd:TIGR01188 150 EPTTGLDPRTRRAIWDYIRALKEE-GVTILLTTHYMEEADKLCDRIAIIDHGRIIAEGTPEEL---------KRRLGKDT 219


                  ....*..
gi 523689182  263 ELAEGRD 269
Cdd:TIGR01188 220 LESRPRD 226

LivF

COG0410

ABC-type branched-chain amino acid transport system, ATPase component LivF [Amino acid ...

6-250

1.43e-30

ABC-type branched-chain amino acid transport system, ATPase component LivF [Amino acid transport and metabolism];

Pssm-ID: 440179 [Multi-domain] Cd Length: 236 Bit Score: 115.46 E-value: 1.43e-30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   6 DAMIDISNLSVtfRRGGkaVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPkgtLIEGGMTVDGHDIMSLSNR 85
Cdd:COG0410    1 MPMLEVENLHA--GYGG--IHVLHGVSLEVEEGEIVALLGRNGAGKTTLLKAISGLLP---PRSGSIRFDGEDITGLPPH 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  86 ALSDlRGavVSMVFQeprlaldpvytvGRQI------EETIM-----RHEKVSRGLAAERALALFqkvriPSPERRLSNY 154
Cdd:COG0410   74 RIAR-LG--IGYVPE------------GRRIfpsltvEENLLlgayaRRDRAEVRADLERVYELF-----PRLKERRRQR 133

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 155 PHEMSGGmlQRAM--IAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMY 232
Cdd:COG0410  134 AGTLSGG--EQQMlaIGRALMSRPKLLLLDEPSLGLAPLIVEEIFEIIRRLNRE-GVTILLVEQNARFALEIADRAYVLE 210

                        250
                 ....*....|....*...
gi 523689182 233 AGRIVEEGLVGDIIRNPR 250
Cdd:COG0410  211 RGRIVLEGTAAELLADPE 228

potA

PRK09452

spermidine/putrescine ABC transporter ATP-binding protein PotA;

2-259

1.66e-30

spermidine/putrescine ABC transporter ATP-binding protein PotA;

Pssm-ID: 236523 [Multi-domain] Cd Length: 375 Bit Score: 118.51 E-value: 1.66e-30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   2 TMQNDAMIDISNLSVTFrrGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHpkgTLIEGGMTVDGHDIMS 81
Cdd:PRK09452   8 PSSLSPLVELRGISKSF--DGKEV--ISNLDLTINNGEFLTLLGPSGCGKTTVLRLIAGFE---TPDSGRIMLDGQDITH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  82 LS--NRAlsdlrgavVSMVFQEprLALDPVYTVgrqiEETI---MRHEKVSRGLAAERALALFQKVRIPS-PERRlsnyP 155
Cdd:PRK09452  81 VPaeNRH--------VNTVFQS--YALFPHMTV----FENVafgLRMQKTPAAEITPRVMEALRMVQLEEfAQRK----P 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 156 HEMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGR 235
Cdd:PRK09452 143 HQLSGGQQQRVAIARAVVNKPKVLLLDESLSALDYKLRKQMQNELKALQRKLGITFVFVTHDQEEALTMSDRIVVMRDGR 222

                        250       260
                 ....*....|....*....|....
gi 523689182 236 IVEEGLVGDIIRNPRHPYTKGLLG 259
Cdd:PRK09452 223 IEQDGTPREIYEEPKNLFVARFIG 246

ABC_TM1139_LivF_branched

cd03224

ATP-binding cassette domain of branched-chain amino acid transporter; LivF (TM1139) is part of ...

9-240

1.74e-30

ATP-binding cassette domain of branched-chain amino acid transporter; LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ). ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules.

Pssm-ID: 213191 [Multi-domain] Cd Length: 222 Bit Score: 114.84 E-value: 1.74e-30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVtfrrGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPkgtLIEGGMTVDGHDIMSLSNRALS 88
Cdd:cd03224    1 LEVENLNA----GYGKSQILFGVSLTVPEGEIVALLGRNGAGKTTLLKTIMGLLP---PRSGSIRFDGRDITGLPPHERA 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  89 DlRGavVSMVFQEPRLAldPVYTVgrqiEETIM------RHEKVSRGLaaERALALFqkvriPSPERRLSNYPHEMSGGm 162
Cdd:cd03224   74 R-AG--IGYVPEGRRIF--PELTV----EENLLlgayarRRAKRKARL--ERVYELF-----PRLKERRKQLAGTLSGG- 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 163 lQRAM--IAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEG 240
Cdd:cd03224  137 -EQQMlaIARALMSRPKLLLLDEPSEGLAPKIVEEIFEAIRELRDE-GVTILLVEQNARFALEIADRAYVLERGRVVLEG 214

potA

TIGR01187

spermidine/putrescine ABC transporter ATP-binding subunit; This model describes spermidine ...

43-259

2.08e-30

spermidine/putrescine ABC transporter ATP-binding subunit; This model describes spermidine/putrescine ABC transporter, ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. Polyamines like spermidine and putrescine play vital role in cell proliferation, differentiation, and ion homeostasis. The concentration of polyamines within the cell are regulated by biosynthesis, degradation and transport (uptake and efflux included). [Transport and binding proteins, Amino acids, peptides and amines]

Pssm-ID: 162242 [Multi-domain] Cd Length: 325 Bit Score: 117.21 E-value: 2.08e-30

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   43 LLGESGSGKSVTMRSLLRLHpkgTLIEGGMTVDGHDImslSNRAlSDLRGavVSMVFQEprLALDPVYTVgrqiEETI-- 120
Cdd:TIGR01187   1 LLGPSGCGKTTLLRLLAGFE---QPDSGSIMLDGEDV---TNVP-PHLRH--INMVFQS--YALFPHMTV----EENVaf 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  121 -MRHEKVSRGLAAERALALFQKVRIpspERRLSNYPHEMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLL 199
Cdd:TIGR01187  66 gLKMRKVPRAEIKPRVLEALRLVQL---EEFADRKPHQLSGGQQQRVALARALVFKPKILLLDEPLSALDKKLRDQMQLE 142

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  200 IRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDIIRNPRHPYTKGLLG 259
Cdd:TIGR01187 143 LKTIQEQLGITFVFVTHDQEEAMTMSDRIAIMRKGKIAQIGTPEEIYEEPANLFVARFIG 202

PRK13633

energy-coupling factor transporter ATPase;

5-240

2.49e-30

energy-coupling factor transporter ATPase;

Pssm-ID: 237453 [Multi-domain] Cd Length: 280 Bit Score: 115.96 E-value: 2.49e-30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   5 NDAMIDISNLSVTFRRGGKAVK--AVNGVSLSVKPGEVVALLGESGSGKSvTMRSllrlHPKGTLI--EGGMTVDGHDIM 80
Cdd:PRK13633   1 MNEMIKCKNVSYKYESNEESTEklALDDVNLEVKKGEFLVILGRNGSGKS-TIAK----HMNALLIpsEGKVYVDGLDTS 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  81 SLSNraLSDLRGAVvSMVFQEPrlaldpvytvGRQIEETIMRhEKVSRGLaaeralalfQKVRIPSPERR---------- 150
Cdd:PRK13633  76 DEEN--LWDIRNKA-GMVFQNP----------DNQIVATIVE-EDVAFGP---------ENLGIPPEEIRervdeslkkv 132

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 151 -LSNY----PHEMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEvA 225
Cdd:PRK13633 133 gMYEYrrhaPHLLSGGQKQRVAIAGILAMRPECIIFDEPTAMLDPSGRREVVNTIKELNKKYGITIILITHYMEEAVE-A 211

                        250
                 ....*....|....*
gi 523689182 226 DRIAVMYAGRIVEEG 240
Cdd:PRK13633 212 DRIIVMDSGKVVMEG 226

ThiQ

COG3840

ABC-type thiamine transport system, ATPase component ThiQ [Coenzyme transport and metabolism];

8-260

2.68e-30

ABC-type thiamine transport system, ATPase component ThiQ [Coenzyme transport and metabolism];

Pssm-ID: 443051 [Multi-domain] Cd Length: 232 Bit Score: 114.47 E-value: 2.68e-30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLsvTFRRGGKAVKAvngvSLSVKPGEVVALLGESGSGKSvTMRSLLR--LHPKGtlieGGMTVDGHDIMSLSnr 85
Cdd:COG3840    1 MLRLDDL--TYRYGDFPLRF----DLTIAAGERVAILGPSGAGKS-TLLNLIAgfLPPDS----GRILWNGQDLTALP-- 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  86 alSDLRGavVSMVFQE------------------PRLALDPvytvgrqiEEtimrHEKVsrglaaERALAlfqKVRIPSP 147
Cdd:COG3840   68 --PAERP--VSMLFQEnnlfphltvaqniglglrPGLKLTA--------EQ----RAQV------EQALE---RVGLAGL 122

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 148 ERRLsnyPHEMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADR 227
Cdd:COG3840  123 LDRL---PGQLSGGQRQRVALARCLVRKRPILLLDEPFSALDPALRQEMLDLVDELCRERGLTVLMVTHDPEDAARIADR 199

                        250       260       270
                 ....*....|....*....|....*....|...
gi 523689182 228 IAVMYAGRIVEEGLVGDIIRNPRHPYTKGLLGA 260
Cdd:COG3840  200 VLLVADGRIAADGPTAALLDGEPPPALAAYLGI 232

ABC_Carb_Monos_I

cd03216

First domain of the ATP-binding cassette component of monosaccharide transport system; This ...

9-237

3.04e-30

First domain of the ATP-binding cassette component of monosaccharide transport system; This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (such as xylose, arabinose, and ribose), that cannot be broken down to simple sugars by hydrolysis. Pentoses include xylose, arabinose, and ribose. Important hexoses include glucose, galactose, and fructose. In members of the Carb_monos family, the single hydrophobic gene product forms a homodimer while the ABC protein represents a fusion of two nucleotide-binding domains. However, it is assumed that two copies of the ABC domains are present in the assembled transporter.

Pssm-ID: 213183 [Multi-domain] Cd Length: 163 Bit Score: 112.52 E-value: 3.04e-30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTFrrGGkaVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGtliEGGMTVDGHDImslSNRALS 88
Cdd:cd03216    1 LELRGITKRF--GG--VKALDGVSLSVRRGEVHALLGENGAGKSTLMKILSGLYKPD---SGEILVDGKEV---SFASPR 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  89 DLRGAVVSMVFQeprlaldpvytvgrqieetimrhekvsrglaaeralalfqkvripsperrlsnypheMSGGMLQRAMI 168
Cdd:cd03216   71 DARRAGIAMVYQ---------------------------------------------------------LSVGERQMVEI 93

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 169 AMALACNPKVLLADEPTTALDATvQIQILL-LIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAGRIV 237
Cdd:cd03216   94 ARALARNARLLILDEPTAALTPA-EVERLFkVIRRLRAQ-GVAVIFISHRLDEVFEIADRVTVLRDGRVV 161

PRK14271

phosphate ABC transporter ATP-binding protein; Provisional

13-259

3.64e-30

phosphate ABC transporter ATP-binding protein; Provisional

Pssm-ID: 172759 [Multi-domain] Cd Length: 276 Bit Score: 115.58 E-value: 3.64e-30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  13 NLSVTFrrGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPK-------GTLIEGGMTV-DGHDIMSLSN 84
Cdd:PRK14271  26 NLTLGF--AGKTV--LDQVSMGFPARAVTSLMGPTGSGKTTFLRTLNRMNDKvsgyrysGDVLLGGRSIfNYRDVLEFRR 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  85 RalsdlrgavVSMVFQEPR---LALDPVYTVGRQIEETIMRHEkvSRGLAAER--ALALFQKVRipspeRRLSNYPHEMS 159
Cdd:PRK14271 102 R---------VGMLFQRPNpfpMSIMDNVLAGVRAHKLVPRKE--FRGVAQARltEVGLWDAVK-----DRLSDSPFRLS 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 160 GGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREygLSVIFVTHDIGVAAEVADRIAVMYAGRIVEE 239
Cdd:PRK14271 166 GGQQQLLCLARTLAVNPEVLLLDEPTSALDPTTTEKIEEFIRSLADR--LTVIIVTHNLAQAARISDRAALFFDGRLVEE 243

                        250       260
                 ....*....|....*....|....
gi 523689182 240 GLVGDIIRNPRHP----YTKGLLG 259
Cdd:PRK14271 244 GPTEQLFSSPKHAetarYVAGLSG 267

fecE

PRK11231

Fe(3+) dicitrate ABC transporter ATP-binding protein FecE;

8-246

4.95e-30

Fe(3+) dicitrate ABC transporter ATP-binding protein FecE;

Pssm-ID: 183044 [Multi-domain] Cd Length: 255 Bit Score: 114.73 E-value: 4.95e-30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSVTFrrGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHpkgTLIEGGMTVDGHDIMSLSNRAL 87
Cdd:PRK11231   2 TLRTENLTVGY--GTKRI--LNDLSLSLPTGKITALIGPNGCGKSTLLKCFARLL---TPQSGTVFLGDKPISMLSSRQL 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  88 SDlrgavvsmvfqepRLALDPVYTVgrqIEETIMRHEKVSRG----------LAAE------RALALFQKVRIPspERRL 151
Cdd:PRK11231  75 AR-------------RLALLPQHHL---TPEGITVRELVAYGrspwlslwgrLSAEdnarvnQAMEQTRINHLA--DRRL 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 152 SnyphEMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVM 231
Cdd:PRK11231 137 T----DLSGGQRQRAFLAMVLAQDTPVVLLDEPTTYLDINHQVELMRLMRELNTQ-GKTVVTVLHDLNQASRYCDHLVVL 211

                        250
                 ....*....|....*
gi 523689182 232 YAGRIVEEGLVGDII 246
Cdd:PRK11231 212 ANGHVMAQGTPEEVM 226

fbpC

PRK11432

ferric ABC transporter ATP-binding protein;

3-249

9.53e-30

ferric ABC transporter ATP-binding protein;

Pssm-ID: 183133 [Multi-domain] Cd Length: 351 Bit Score: 115.97 E-value: 9.53e-30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   3 MQNDAMIDISNLSVTFrrgGKAVkAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHpKGTliEGGMTVDGHDIM-- 80
Cdd:PRK11432   1 MTQKNFVVLKNITKRF---GSNT-VIDNLNLTIKQGTMVTLLGPSGCGKTTVLRLVAGLE-KPT--EGQIFIDGEDVThr 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  81 SLSNRAlsdlrgavVSMVFQEprLALDPVYTVGRQIEETiMRHEKVSRGLAAER---ALALfqkVRIPSPERRlsnYPHE 157
Cdd:PRK11432  74 SIQQRD--------ICMVFQS--YALFPHMSLGENVGYG-LKMLGVPKEERKQRvkeALEL---VDLAGFEDR---YVDQ 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 158 MSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIV 237
Cdd:PRK11432 137 ISGGQQQRVALARALILKPKVLLFDEPLSNLDANLRRSMREKIRELQQQFNITSLYVTHDQSEAFAVSDTVIVMNKGKIM 216

                        250
                 ....*....|..
gi 523689182 238 EEGLVGDIIRNP 249
Cdd:PRK11432 217 QIGSPQELYRQP 228

ABC_ModC_molybdenum_transporter

cd03297

ATP-binding cassette domain of the molybdenum transport system; ModC is an ABC-type ...

37-240

1.45e-29

ATP-binding cassette domain of the molybdenum transport system; ModC is an ABC-type transporter and the ATPase component of a molybdate transport system that also includes the periplasmic binding protein ModA and the membrane protein ModB. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213264 [Multi-domain] Cd Length: 214 Bit Score: 112.00 E-value: 1.45e-29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  37 PGEVVALLGESGSGKSvtmrSLLRLhpkgtlIEGGMTVDGHDImSLSNRALSDLRGAV--------VSMVFQEprLALDP 108
Cdd:cd03297   22 NEEVTGIFGASGAGKS----TLLRC------IAGLEKPDGGTI-VLNGTVLFDSRKKInlppqqrkIGLVFQQ--YALFP 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 109 VYTVGRQIEETIMRHEKVSRGLAAERALALFQkvrIPSPERRlsnYPHEMSGGMLQRAMIAMALACNPKVLLADEPTTAL 188
Cdd:cd03297   89 HLNVRENLAFGLKRKRNREDRISVDELLDLLG---LDHLLNR---YPAQLSGGEKQRVALARALAAQPELLLLDEPFSAL 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 523689182 189 DATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEG 240
Cdd:cd03297  163 DRALRLQLLPELKQIKKNLNIPVIFVTHDLSEAEYLADRIVVMEDGRLQYIG 214

PRK14267

phosphate ABC transporter ATP-binding protein; Provisional

9-259

2.49e-29

phosphate ABC transporter ATP-binding protein; Provisional

Pssm-ID: 184596 [Multi-domain] Cd Length: 253 Bit Score: 112.63 E-value: 2.49e-29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTFRRGgkavKAVNGVSLSVKPGEVVALLGESGSGKSVTMRS---LLRLHPKGTlIEGGMTVDGHDIMSLSNR 85
Cdd:PRK14267   5 IETVNLRVYYGSN----HVIKGVDLKIPQNGVFALMGPSGCGKSTLLRTfnrLLELNEEAR-VEGEVRLFGRNIYSPDVD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  86 ALSDLRGavVSMVFQEP----RLALDPVYTVGRQIEETIMRHEKVSRGLA-AERALALFQKVRipspeRRLSNYPHEMSG 160
Cdd:PRK14267  80 PIEVRRE--VGMVFQYPnpfpHLTIYDNVAIGVKLNGLVKSKKELDERVEwALKKAALWDEVK-----DRLNDYPSNLSG 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 161 GMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYglSVIFVTHDIGVAAEVADRIAVMYAGRIVEEG 240
Cdd:PRK14267 153 GQRQRLVIARALAMKPKILLMDEPTANIDPVGTAKIEELLFELKKEY--TIVLVTHSPAQAARVSDYVAFLYLGKLIEVG 230

                        250       260
                 ....*....|....*....|...
gi 523689182 241 LVGDIIRNPRHP----YTKGLLG 259
Cdd:PRK14267 231 PTRKVFENPEHEltekYVTGALG 253

cbiO

PRK13639

cobalt transporter ATP-binding subunit; Provisional

8-249

2.83e-29

cobalt transporter ATP-binding subunit; Provisional

Pssm-ID: 184199 [Multi-domain] Cd Length: 275 Bit Score: 113.25 E-value: 2.83e-29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSVTFRRGGKAVKavnGVSLSVKPGEVVALLGESGSGKSVTMrsllrLHPKGTL--IEGGMTVDGHDImSLSNR 85
Cdd:PRK13639   1 ILETRDLKYSYPDGTEALK---GINFKAEKGEMVALLGPNGAGKSTLF-----LHFNGILkpTSGEVLIKGEPI-KYDKK 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  86 ALSDLRgAVVSMVFQEPRlalDPVY--TVGRQIEETIMrHEKVSRGLAAERALALFQKVRIPSPERRLsnyPHEMSGGML 163
Cdd:PRK13639  72 SLLEVR-KTVGIVFQNPD---DQLFapTVEEDVAFGPL-NLGLSKEEVEKRVKEALKAVGMEGFENKP---PHHLSGGQK 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 164 QRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVG 243
Cdd:PRK13639 144 KRVAIAGILAMKPEIIVLDEPTSGLDPMGASQIMKLLYDLNKE-GITIIISTHDVDLVPVYADKVYVMSDGKIIKEGTPK 222


                 ....*.
gi 523689182 244 DIIRNP 249
Cdd:PRK13639 223 EVFSDI 228

PRK10535

macrolide ABC transporter ATP-binding protein/permease MacB;

7-237

5.98e-29

macrolide ABC transporter ATP-binding protein/permease MacB;

Pssm-ID: 182528 [Multi-domain] Cd Length: 648 Bit Score: 116.75 E-value: 5.98e-29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   7 AMIDISNLSVTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHpKGTliEGGMTVDGHDIMSLSNRA 86
Cdd:PRK10535   3 ALLELKDIRRSYPSGEEQVEVLKGISLDIYAGEMVAIVGASGSGKSTLMNILGCLD-KPT--SGTYRVAGQDVATLDADA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  87 LSDLRGAVVSMVFQepRLALDPVYTVGRQIEETIMrHEKVSRGLAAERALALFQKVRIpspERRLSNYPHEMSGGMLQRA 166
Cdd:PRK10535  80 LAQLRREHFGFIFQ--RYHLLSHLTAAQNVEVPAV-YAGLERKQRLLRAQELLQRLGL---EDRVEYQPSQLSGGQQQRV 153

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 523689182 167 MIAMALACNPKVLLADEPTTALDATVQIQILLLIRELqREYGLSVIFVTHDIGVAAEvADRIAVMYAGRIV 237
Cdd:PRK10535 154 SIARALMNGGQVILADEPTGALDSHSGEEVMAILHQL-RDRGHTVIIVTHDPQVAAQ-AERVIEIRDGEIV 222

YhaQ

COG4152

ABC-type uncharacterized transport system, ATPase component [General function prediction only]; ...

8-266

1.13e-28

ABC-type uncharacterized transport system, ATPase component [General function prediction only];

Pssm-ID: 443322 [Multi-domain] Cd Length: 298 Bit Score: 111.74 E-value: 1.13e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSVTFrrggKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLR-LHPKgtliEGGMTVDGHDImSLSNRA 86
Cdd:COG4152    1 MLELKGLTKRF----GDKTAVDDVSFTVPKGEIFGLLGPNGAGKTTTIRIILGiLAPD----SGEVLWDGEPL-DPEDRR 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  87 ----LSDLRGavvsmvfqeprlaLDPVYTVGRQIEETIMRHeKVSRGLAAERALALFQKVRIPS-PERRLsnypHEMSGG 161
Cdd:COG4152   72 rigyLPEERG-------------LYPKMKVGEQLVYLARLK-GLSKAEAKRRADEWLERLGLGDrANKKV----EELSKG 133

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 162 MLQRAMIAMALACNPKVLLADEPTTALDAtVQIQILL-LIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEG 240
Cdd:COG4152  134 NQQKVQLIAALLHDPELLILDEPFSGLDP-VNVELLKdVIRELAAK-GTTVIFSSHQMELVEELCDRIVIINKGRKVLSG 211

                        250       260
                 ....*....|....*....|....*.
gi 523689182 241 LVGDiIRNpRHPYTKGLLGARVELAE 266
Cdd:COG4152  212 SVDE-IRR-QFGRNTLRLEADGDAGW 235

cbiO

PRK13634

cobalt transporter ATP-binding subunit; Provisional

26-249

1.39e-28

cobalt transporter ATP-binding subunit; Provisional

Pssm-ID: 237454 [Multi-domain] Cd Length: 290 Bit Score: 111.65 E-value: 1.39e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  26 KAVNGVSLSVKPGEVVALLGESGSGKSvtmrSLLRlHPKGTL--IEGGMTVDGHDIMS-LSNRALSDLRGAVvSMVFQEP 102
Cdd:PRK13634  21 RALYDVNVSIPSGSYVAIIGHTGSGKS----TLLQ-HLNGLLqpTSGTVTIGERVITAgKKNKKLKPLRKKV-GIVFQFP 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 103 RLALdpvytvgrqIEETImrhEK----------VSRGLAAERALALFQKVRIPspERRLSNYPHEMSGGMLQRAMIAMAL 172
Cdd:PRK13634  95 EHQL---------FEETV---EKdicfgpmnfgVSEEDAKQKAREMIELVGLP--EELLARSPFELSGGQMRRVAIAGVL 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 523689182 173 ACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDIIRNP 249
Cdd:PRK13634 161 AMEPEVLVLDEPTAGLDPKGRKEMMEMFYKLHKEKGLTTVLVTHSMEDAARYADQIVVMHKGTVFLQGTPREIFADP 237

tungstate_WtpC

NF040840

tungstate ABC transporter ATP-binding protein WtpC;

8-259

1.48e-28

tungstate ABC transporter ATP-binding protein WtpC;

Pssm-ID: 468779 [Multi-domain] Cd Length: 347 Bit Score: 112.86 E-value: 1.48e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSvtfrRGGKAVKaVNGVSLSVKPGEVVALLGESGSGKSVtmrsLLRLhpkgtlIEGGMTVDGHDIMsLSNRAL 87
Cdd:NF040840   1 MIRIENLS----KDWKEFK-LRDISLEVKEGEYFIILGPSGAGKTV----LLEL------IAGIWPPDSGKIY-LDGKDI 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  88 SDL----RGavVSMVFQEprLALDPVYTVGRQIEETiMRHEKVSRGLAAERALALFQKVRIpspERRLSNYPHEMSGGML 163
Cdd:NF040840  65 TNLppekRG--IAYVYQN--YMLFPHKTVFENIAFG-LKLRKVPKEEIERKVKEIMELLGI---SHLLHRKPRTLSGGEQ 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 164 QRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVG 243
Cdd:NF040840 137 QRVALARALIIEPKLLLLDEPLSALDVQTRDELIREMKRWHREFGFTAIHVTHNFEEALSLADRVGIMLNGRLSQVGDVR 216

                        250
                 ....*....|....*.
gi 523689182 244 DIIRNPRHPYTKGLLG 259
Cdd:NF040840 217 EVFRRPKNEFVARFVG 232

cbiO

PRK13632

cobalt transporter ATP-binding subunit; Provisional

5-248

2.81e-28

cobalt transporter ATP-binding subunit; Provisional

Pssm-ID: 237452 [Multi-domain] Cd Length: 271 Bit Score: 110.47 E-value: 2.81e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   5 NDAMIDISNlsVTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSvTMRSLLR--LHPKgtliEGGMTVDGHDImsl 82
Cdd:PRK13632   4 KSVMIKVEN--VSFSYPNSENNALKNVSFEINEGEYVAILGHNGSGKS-TISKILTglLKPQ----SGEIKIDGITI--- 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  83 SNRALSDLRGAVvSMVFQEPrlalDPVYtVGRQIEETI---MRHEKVSRGLAAERALALFQKVRIpspERRLSNYPHEMS 159
Cdd:PRK13632  74 SKENLKEIRKKI-GIIFQNP----DNQF-IGATVEDDIafgLENKKVPPKKMKDIIDDLAKKVGM---EDYLDKEPQNLS 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 160 GGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAeVADRIAVMYAGRIVEE 239
Cdd:PRK13632 145 GGQKQRVAIASVLALNPEIIIFDESTSMLDPKGKREIKKIMVDLRKTRKKTLISITHDMDEAI-LADKVIVFSEGKLIAQ 223


                 ....*....
gi 523689182 240 GLVGDIIRN 248
Cdd:PRK13632 224 GKPKEILNN 232

ModC

COG4148

ABC-type molybdate transport system, ATPase component ModC [Inorganic ion transport and ...

7-249

3.53e-28

ABC-type molybdate transport system, ATPase component ModC [Inorganic ion transport and metabolism]; ABC-type molybdate transport system, ATPase component ModC is part of the Pathway/BioSystem: Molybdopterin biosynthesis

Pssm-ID: 443319 [Multi-domain] Cd Length: 358 Bit Score: 111.73 E-value: 3.53e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   7 AMIDISnlsVTFRRGGKAVKavngVSLSVKPGEVVALLGESGSGKSvtmrSLLRlhpkgtLIEGGMTVDGHDImSLSNRA 86
Cdd:COG4148    1 MMLEVD---FRLRRGGFTLD----VDFTLPGRGVTALFGPSGSGKT----TLLR------AIAGLERPDSGRI-RLGGEV 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  87 LSDLRGAV--------VSMVFQEPRlaLDPVYTVGRQIEETIMRHEKVSRGLAAERALALFQkvrIpspERRLSNYPHEM 158
Cdd:COG4148   63 LQDSARGIflpphrrrIGYVFQEAR--LFPHLSVRGNLLYGRKRAPRAERRISFDEVVELLG---I---GHLLDRRPATL 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 159 SGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVE 238
Cdd:COG4148  135 SGGERQRVAIGRALLSSPRLLLMDEPLAALDLARKAEILPYLERLRDELDIPILYVSHSLDEVARLADHVVLLEQGRVVA 214

                        250
                 ....*....|.
gi 523689182 239 EGLVGDIIRNP 249
Cdd:COG4148  215 SGPLAEVLSRP 225

btuD

PRK09536

corrinoid ABC transporter ATPase; Reviewed

8-283

1.12e-27

corrinoid ABC transporter ATPase; Reviewed

Pssm-ID: 236554 [Multi-domain] Cd Length: 402 Bit Score: 111.09 E-value: 1.12e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSVTFrrGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSVTMRSLlrlhpKGTL--IEGGMTVDGHDIMSLSNR 85
Cdd:PRK09536   3 MIDVSDLSVEF--GDTTV--LDGVDLSVREGSLVGLVGPNGAGKTTLLRAI-----NGTLtpTAGTVLVAGDDVEALSAR 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  86 ALSDLrgavVSMVFQEPRLALDpvYTVgRQIEEtIMRHEKVSR--------GLAAERALALFQKVRIPspERRLSnyphE 157
Cdd:PRK09536  74 AASRR----VASVPQDTSLSFE--FDV-RQVVE-MGRTPHRSRfdtwtetdRAAVERAMERTGVAQFA--DRPVT----S 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 158 MSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAGRIV 237
Cdd:PRK09536 140 LSGGERQRVLLARALAQATPVLLLDEPTASLDINHQVRTLELVRRLVDD-GKTAVAAIHDLDLAARYCDELVLLADGRVR 218

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 523689182 238 EEGLVGDIIRNPRhpyTKGLLGARV----ELAEGRDRLVTIPGAPPDLAA 283
Cdd:PRK09536 219 AAGPPADVLTADT---LRAAFDARTavgtDPATGAPTVTPLPDPDRTEAA 265

MdlB

COG1132

ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms];

16-240

1.56e-27

ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms];

Pssm-ID: 440747 [Multi-domain] Cd Length: 579 Bit Score: 112.57 E-value: 1.56e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  16 VTFRRGGKAvKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPkgtLIEGGMTVDGHDIMSLSnraLSDLRGAvV 95
Cdd:COG1132  345 VSFSYPGDR-PVLKDISLTIPPGETVALVGPSGSGKSTLVNLLLRFYD---PTSGRILIDGVDIRDLT---LESLRRQ-I 416

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  96 SMVFQEPRLALDPVY---TVGR---------------QIEETIMRHEKvsrGLAA---ERALALfqkvripsperrlsny 154
Cdd:COG1132  417 GVVPQDTFLFSGTIReniRYGRpdatdeeveeaakaaQAHEFIEALPD---GYDTvvgERGVNL---------------- 477

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 155 phemSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQReyGLSVIFVTHDIGVAAEvADRIAVMYAG 234
Cdd:COG1132  478 ----SGGQRQRIAIARALLKDPPILILDEATSALDTETEALIQEALERLMK--GRTTIVIAHRLSTIRN-ADRILVLDDG 550


                 ....*.
gi 523689182 235 RIVEEG 240
Cdd:COG1132  551 RIVEQG 556

PhnT

TIGR03258

2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; This ATP-binding ...

9-260

3.84e-27

2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; This ATP-binding component of an ABC transport system is found in Salmonella and Burkholderia lineages in the vicinity of enzymes for the breakdown of 2-aminoethylphosphonate.

Pssm-ID: 132302 [Multi-domain] Cd Length: 362 Bit Score: 109.31 E-value: 3.84e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182    9 IDISNLSVtfRRGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLR-LHPKGtlIEGGMTVDGHDIMSLSNRAl 87
Cdd:TIGR03258   6 IRIDHLRV--AYGANTV--LDDLSLEIEAGELLALIGKSGCGKTTLLRAIAGfVKAAG--LTGRIAIADRDLTHAPPHK- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   88 sdlRGavVSMVFQEprLALDPVYTVgrqiEETI---MRHEKVSRGLAAERALALFQKVRIPSPERRlsnYPHEMSGGMLQ 164
Cdd:TIGR03258  79 ---RG--LALLFQN--YALFPHLKV----EDNVafgLRAQKMPKADIAERVADALKLVGLGDAAAH---LPAQLSGGMQQ 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  165 RAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREY-GLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVG 243
Cdd:TIGR03258 145 RIAIARAIAIEPDVLLLDEPLSALDANIRANMREEIAALHEELpELTILCVTHDQDDALTLADKAGIMKDGRLAAHGEPQ 224

                         250
                  ....*....|....*..
gi 523689182  244 DIIRNPRHPYTKGLLGA 260
Cdd:TIGR03258 225 ALYDAPADGFAAEFLGA 241

NupO

COG3845

ABC-type guanosine uptake system NupNOPQ, ATPase component NupO [Nucleotide transport and ...

6-239

3.87e-27

ABC-type guanosine uptake system NupNOPQ, ATPase component NupO [Nucleotide transport and metabolism];

Pssm-ID: 443055 [Multi-domain] Cd Length: 504 Bit Score: 110.89 E-value: 3.87e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   6 DAMIDISNLSVTFRRGGKAVKavnGVSLSVKPGEVVALLGESGSGKSVTMRSL--LRLHPKGTlieggMTVDGHDIMSLS 83
Cdd:COG3845  255 EVVLEVENLSVRDDRGVPALK---DVSLEVRAGEILGIAGVAGNGQSELAEALagLRPPASGS-----IRLDGEDITGLS 326

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  84 NRALSDLRGAVVSmvfqEPRL--ALDPVYTV------GRQIEETIMRHEKVSRGLAAERALALFQK--VRIPSPERRLSN 153
Cdd:COG3845  327 PRERRRLGVAYIP----EDRLgrGLVPDMSVaenlilGRYRRPPFSRGGFLDRKAIRAFAEELIEEfdVRTPGPDTPARS 402

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 154 ypheMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELqREYGLSVIFVTHDIGVAAEVADRIAVMYA 233
Cdd:COG3845  403 ----LSGGNQQKVILARELSRDPKLLIAAQPTRGLDVGAIEFIHQRLLEL-RDAGAAVLLISEDLDEILALSDRIAVMYE 477


                 ....*.
gi 523689182 234 GRIVEE 239
Cdd:COG3845  478 GRIVGE 483

CydD

COG4988

ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease ...

5-240

5.33e-27

ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];

Pssm-ID: 444012 [Multi-domain] Cd Length: 563 Bit Score: 111.00 E-value: 5.33e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   5 NDAMIDISNLSVtfrRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPkgtLIEGGMTVDGHDIMSLSN 84
Cdd:COG4988  333 GPPSIELEDVSF---SYPGGRPALDGLSLTIPPGERVALVGPSGAGKSTLLNLLLGFLP---PYSGSILINGVDLSDLDP 406

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  85 RALSDLrgavVSMVFQEPRL---------AL-DPVYTvgrqiEETIMRhekvsrglAAERA-LALFqkvrIPSPERRLSN 153
Cdd:COG4988  407 ASWRRQ----IAWVPQNPYLfagtirenlRLgRPDAS-----DEELEA--------ALEAAgLDEF----VAALPDGLDT 465

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 154 YPHE----MSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQReyGLSVIFVTHDIGVAAEvADRIA 229
Cdd:COG4988  466 PLGEggrgLSGGQAQRLALARALLRDAPLLLLDEPTAHLDAETEAEILQALRRLAK--GRTVILITHRLALLAQ-ADRIL 542

                        250
                 ....*....|.
gi 523689182 230 VMYAGRIVEEG 240
Cdd:COG4988  543 VLDDGRIVEQG 553

cbiO

PRK13640

energy-coupling factor transporter ATPase;

5-249

5.86e-27

energy-coupling factor transporter ATPase;

Pssm-ID: 184200 [Multi-domain] Cd Length: 282 Bit Score: 107.19 E-value: 5.86e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   5 NDAMIDISNLSVTFRRGGKAvkAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGTLIEGGMTVDGhdiMSLSN 84
Cdd:PRK13640   2 KDNIVEFKHVSFTYPDSKKP--ALNDISFSIPRGSWTALIGHNGSGKSTISKLINGLLLPDDNPNSKITVDG---ITLTA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  85 RALSDLRGAVvSMVFQEPrlalDPVY---TVG---------RQIEETIMRheKVSRGLAAERALALFQKVRipsperrls 152
Cdd:PRK13640  77 KTVWDIREKV-GIVFQNP----DNQFvgaTVGddvafglenRAVPRPEMI--KIVRDVLADVGMLDYIDSE--------- 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 153 nyPHEMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGvAAEVADRIAVMY 232
Cdd:PRK13640 141 --PANLSGGQKQRVAIAGILAVEPKIIILDESTSMLDPAGKEQILKLIRKLKKKNNLTVISITHDID-EANMADQVLVLD 217

                        250
                 ....*....|....*..
gi 523689182 233 AGRIVEEGLVGDIIRNP 249
Cdd:PRK13640 218 DGKLLAQGSPVEIFSKV 234

PRK13549

xylose transporter ATP-binding subunit; Provisional

24-235

6.36e-27

xylose transporter ATP-binding subunit; Provisional

Pssm-ID: 184134 [Multi-domain] Cd Length: 506 Bit Score: 110.40 E-value: 6.36e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  24 AVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGTLiEGGMTVDGHDimsLSNRALSDLRGAVVSMVFQEpr 103
Cdd:PRK13549  17 GVKALDNVSLKVRAGEIVSLCGENGAGKSTLMKVLSGVYPHGTY-EGEIIFEGEE---LQASNIRDTERAGIAIIHQE-- 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 104 LALDPVYTVGRQIeetIMRHEKVSRGLAA-----ERALALFQKVRIP-SPERRLSNYphemSGGMLQRAMIAMALACNPK 177
Cdd:PRK13549  91 LALVKELSVLENI---FLGNEITPGGIMDydamyLRAQKLLAQLKLDiNPATPVGNL----GLGQQQLVEIAKALNKQAR 163

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 523689182 178 VLLADEPTTALDATvQIQILL-LIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAGR 235
Cdd:PRK13549 164 LLILDEPTASLTES-ETAVLLdIIRDLKAH-GIACIYISHKLNEVKAISDTICVIRDGR 220

potG

PRK11607

putrescine ABC transporter ATP-binding subunit PotG;

8-267

8.31e-27

putrescine ABC transporter ATP-binding subunit PotG;

Pssm-ID: 183226 [Multi-domain] Cd Length: 377 Bit Score: 108.38 E-value: 8.31e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSVTFrrggKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKgtlIEGGMTVDGHDIMSLSNRAL 87
Cdd:PRK11607  19 LLEIRNLTKSF----DGQHAVDDVSLTIYKGEIFALLGASGCGKSTLLRMLAGFEQP---TAGQIMLDGVDLSHVPPYQR 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  88 SdlrgavVSMVFQEprLALDPVYTVGRQIEETiMRHEKVSRGLAAERALALFQKVRIPSPERRlsnYPHEMSGGMLQRAM 167
Cdd:PRK11607  92 P------INMMFQS--YALFPHMTVEQNIAFG-LKQDKLPKAEIASRVNEMLGLVHMQEFAKR---KPHQLSGGQRQRVA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 168 IAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDIIR 247
Cdd:PRK11607 160 LARSLAKRPKLLLLDEPMGALDKKLRDRMQLEVVDILERVGVTCVMVTHDQEEAMTMAGRIAIMNRGKFVQIGEPEEIYE 239

                        250       260
                 ....*....|....*....|
gi 523689182 248 NPRHPYTKGLLGArVELAEG 267
Cdd:PRK11607 240 HPTTRYSAEFIGS-VNVFEG 258

ABC_cobalt_CbiO_domain2

cd03226

Second domain of the ATP-binding cassette component of cobalt transport system; Domain II of ...

10-237

1.02e-26

Second domain of the ATP-binding cassette component of cobalt transport system; Domain II of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. The CbiMNQO family ABC transport system is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems.

Pssm-ID: 213193 [Multi-domain] Cd Length: 205 Bit Score: 104.26 E-value: 1.02e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  10 DISNLSVTFRRGGKAVKavnGVSLSVKPGEVVALLGESGSGKSVTMR---SLLRLHpKGTLIEGGmtvdghdimslSNRA 86
Cdd:cd03226    1 RIENISFSYKKGTEILD---DLSLDLYAGEIIALTGKNGAGKTTLAKilaGLIKES-SGSILLNG-----------KPIK 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  87 LSDLRGAVvSMVFQEPRLAL--DPVYtvgrqiEETIMRHEKVSRGlaAERALALFQKVRIPSPERRlsnYPHEMSGGMLQ 164
Cdd:cd03226   66 AKERRKSI-GYVMQDVDYQLftDSVR------EELLLGLKELDAG--NEQAETVLKDLDLYALKER---HPLSLSGGQKQ 133

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 523689182 165 RAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAGRIV 237
Cdd:cd03226  134 RLAIAAALLSGKDLLIFDEPTSGLDYKNMERVGELIRELAAQ-GKAVIVITHDYEFLAKVCDRVLLLANGAIV 205

cbiO

PRK13646

energy-coupling factor transporter ATPase;

9-240

2.02e-26

energy-coupling factor transporter ATPase;

Pssm-ID: 184205 [Multi-domain] Cd Length: 286 Bit Score: 105.63 E-value: 2.02e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTFRRGGK-AVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGTlieGGMTVDGHDIMSLS-NRA 86
Cdd:PRK13646   3 IRFDNVSYTYQKGTPyEHQAIHDVNTEFEQGKYYAIVGQTGSGKSTLIQNINALLKPTT---GTVTVDDITITHKTkDKY 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  87 LSDLRGAVvSMVFQEPRLAL--DpvyTVGRQIE----ETIMRHEKVSrglaaERALALFqkVRIPSPERRLSNYPHEMSG 160
Cdd:PRK13646  80 IRPVRKRI-GMVFQFPESQLfeD---TVEREIIfgpkNFKMNLDEVK-----NYAHRLL--MDLGFSRDVMSQSPFQMSG 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 161 GMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEG 240
Cdd:PRK13646 149 GQMRKIAIVSILAMNPDIIVLDEPTAGLDPQSKRQVMRLLKSLQTDENKTIILVSHDMNEVARYADEVIVMKEGSIVSQT 228

cbiO

PRK13641

energy-coupling factor transporter ATPase;

26-249

2.16e-26

energy-coupling factor transporter ATPase;

Pssm-ID: 237456 [Multi-domain] Cd Length: 287 Bit Score: 105.68 E-value: 2.16e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  26 KAVNGVSLSVKPGEVVALLGESGSGKSVTMRsllrlHPKGTLI--EGGMTVDGHDIMS-LSNRALSDLRGAVvSMVFQEP 102
Cdd:PRK13641  21 KGLDNISFELEEGSFVALVGHTGSGKSTLMQ-----HFNALLKpsSGTITIAGYHITPeTGNKNLKKLRKKV-SLVFQFP 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 103 RLALdpvytvgrqIEETIMRHEK-------VSRGLAAERALALFQKVRIPspERRLSNYPHEMSGGMLQRAMIAMALACN 175
Cdd:PRK13641  95 EAQL---------FENTVLKDVEfgpknfgFSEDEAKEKALKWLKKVGLS--EDLISKSPFELSGGQMRRVAIAGVMAYE 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 523689182 176 PKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDIIRNP 249
Cdd:PRK13641 164 PEILCLDEPAAGLDPEGRKEMMQLFKDYQKA-GHTVILVTHNMDDVAEYADDVLVLEHGKLIKHASPKEIFSDK 236

NupO

COG3845

ABC-type guanosine uptake system NupNOPQ, ATPase component NupO [Nucleotide transport and ...

5-313

2.17e-26

ABC-type guanosine uptake system NupNOPQ, ATPase component NupO [Nucleotide transport and metabolism];

Pssm-ID: 443055 [Multi-domain] Cd Length: 504 Bit Score: 108.58 E-value: 2.17e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   5 NDAMIDISNLSVTFrrGGkaVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGtliEGGMTVDGH--DIMSl 82
Cdd:COG3845    2 MPPALELRGITKRF--GG--VVANDDVSLTVRPGEIHALLGENGAGKSTLMKILYGLYQPD---SGEILIDGKpvRIRS- 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  83 SNRALSdlRGavVSMVFQEPRLAldPVYTVgrqIEETIMRHEKVSRGL-----AAERALALFQKVRIP-SPERRLsnypH 156
Cdd:COG3845   74 PRDAIA--LG--IGMVHQHFMLV--PNLTV---AENIVLGLEPTKGGRldrkaARARIRELSERYGLDvDPDAKV----E 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 157 EMSGGMLQRAMIAMALACNPKVLLADEPTTALdaTVQ-IQILL-LIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAG 234
Cdd:COG3845  141 DLSVGEQQRVEILKALYRGARILILDEPTAVL--TPQeADELFeILRRLAAE-GKSIIFITHKLREVMAIADRVTVLRRG 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 235 RIVEEGLVGDIIRNprhpytkgllgarvELAE---GRDRLVTIPGAPPdlaamPPGcafaPRCVQVSDLCQKQIPPLLPL 311
Cdd:COG3845  218 KVVGTVDTAETSEE--------------ELAElmvGREVLLRVEKAPA-----EPG----EVVLEVENLSVRDDRGVPAL 274


                 ..
gi 523689182 312 SG 313
Cdd:COG3845  275 KD 276

PhnK

COG1101

ABC-type uncharacterized transport system, ATPase component [General function prediction only]; ...

8-237

2.46e-26

ABC-type uncharacterized transport system, ATPase component [General function prediction only];

Pssm-ID: 440718 [Multi-domain] Cd Length: 264 Bit Score: 104.78 E-value: 2.46e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSVTFRRG-GKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLlrlhpKGTLI--EGGMTVDGHDI--MSL 82
Cdd:COG1101    1 MLELKNLSKTFNPGtVNEKRALDGLNLTIEEGDFVTVIGSNGAGKSTLLNAI-----AGSLPpdSGSILIDGKDVtkLPE 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  83 SNRAlsdlrgAVVSMVFQEPRLAldpvyTVGR-QIEETI----MRHEK--VSRGLAAERaLALFQKvRIPSPERRLSNYP 155
Cdd:COG1101   76 YKRA------KYIGRVFQDPMMG-----TAPSmTIEENLalayRRGKRrgLRRGLTKKR-RELFRE-LLATLGLGLENRL 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 156 HE----MSGGmlQRAMIA--MALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIA 229
Cdd:COG1101  143 DTkvglLSGG--QRQALSllMATLTKPKLLLLDEHTAALDPKTAALVLELTEKIVEENNLTTLMVTHNMEQALDYGNRLI 220


                 ....*...
gi 523689182 230 VMYAGRIV 237
Cdd:COG1101  221 MMHEGRII 228

cbiO

PRK13642

energy-coupling factor transporter ATPase;

6-240

7.90e-26

energy-coupling factor transporter ATPase;

Pssm-ID: 184202 [Multi-domain] Cd Length: 277 Bit Score: 104.02 E-value: 7.90e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   6 DAMIDISNLSVTFRRGGKaVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKgtlIEGGMTVDGHdimSLSNR 85
Cdd:PRK13642   2 NKILEVENLVFKYEKESD-VNQLNGVSFSITKGEWVSIIGQNGSGKSTTARLIDGLFEE---FEGKVKIDGE---LLTAE 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  86 ALSDLRGAvVSMVFQEPRLALdpvytVGRQIEETI---MRHEKVSRGLAAERALALFQKVRIPSPERRlsnYPHEMSGGM 162
Cdd:PRK13642  75 NVWNLRRK-IGMVFQNPDNQF-----VGATVEDDVafgMENQGIPREEMIKRVDEALLAVNMLDFKTR---EPARLSGGQ 145

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 523689182 163 LQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEvADRIAVMYAGRIVEEG 240
Cdd:PRK13642 146 KQRVAVAGIIALRPEIIILDESTSMLDPTGRQEIMRVIHEIKEKYQLTVLSITHDLDEAAS-SDRILVMKAGEIIKEA 222

CydC

COG4987

ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease ...

16-240

1.79e-25

ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];

Pssm-ID: 444011 [Multi-domain] Cd Length: 569 Bit Score: 106.39 E-value: 1.79e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  16 VTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPkgtLIEGGMTVDGHDIMSLSNRALSdlrgAVV 95
Cdd:COG4987  339 VSFRYPGAGRPVLDGLSLTLPPGERVAIVGPSGSGKSTLLALLLRFLD---PQSGSITLGGVDLRDLDEDDLR----RRI 411

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  96 SMVFQEPRLaldpvytvgrqIEETIMRHEKVSRGLAAERAL--ALfQKVRIpspERRLSNYPH-----------EMSGGM 162
Cdd:COG4987  412 AVVPQRPHL-----------FDTTLRENLRLARPDATDEELwaAL-ERVGL---GDWLAALPDgldtwlgeggrRLSGGE 476

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 523689182 163 LQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQReyGLSVIFVTHDIgVAAEVADRIAVMYAGRIVEEG 240
Cdd:COG4987  477 RRRLALARALLRDAPILLLDEPTEGLDAATEQALLADLLEALA--GRTVLLITHRL-AGLERMDRILVLEDGRIVEQG 551

ABC_MTABC3_MDL1_MDL2

cd03249

ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; MTABC3 ...

25-240

2.11e-25

ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the yeast MDL1 (multidrug resistance-like protein 1) and MDL2 (multidrug resistance-like protein 2) transporters are also included in this CD. MDL1 is an ATP-dependent permease that acts as a high-copy suppressor of ATM1 and is thought to have a role in resistance to oxidative stress. Interestingly, subfamily B is more closely related to the carboxyl-terminal component of subfamily C than the two halves of ABCC molecules are with one another.

Pssm-ID: 213216 [Multi-domain] Cd Length: 238 Bit Score: 101.85 E-value: 2.11e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  25 VKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHpkgTLIEGGMTVDGHDIMSLSNRALSDLrgavVSMVFQEPRL 104
Cdd:cd03249   16 VPILKGLSLTIPPGKTVALVGSSGCGKSTVVSLLERFY---DPTSGEILLDGVDIRDLNLRWLRSQ----IGLVSQEPVL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 105 -----ALDPVYTVGRQIEETIMRhekvsrglAAERALALFQKVRIPSP-ERRLSNYPHEMSGGMLQRAMIAMALACNPKV 178
Cdd:cd03249   89 fdgtiAENIRYGKPDATDEEVEE--------AAKKANIHDFIMSLPDGyDTLVGERGSQLSGGQKQRIAIARALLRNPKI 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 523689182 179 LLADEPTTALDATVQIQILLLIRELQReyGLSVIFVTHDIGvAAEVADRIAVMYAGRIVEEG 240
Cdd:cd03249  161 LLLDEATSALDAESEKLVQEALDRAMK--GRTTIVIAHRLS-TIRNADLIAVLQNGQVVEQG 219

ABC_BcrA_bacitracin_resist

cd03268

ATP-binding cassette domain of the bacitracin-resistance transporter; The BcrA subfamily ...

9-240

2.54e-25

ATP-binding cassette domain of the bacitracin-resistance transporter; The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multi-enzyme complex BcrABC. Bacitracin has potent antibiotic activity against gram-positive bacteria. The inhibition of peptidoglycan biosynthesis is the best characterized bacterial effect of bacitracin. The bacitracin resistance of B. licheniformis is mediated by the ABC transporter Bcr which is composed of two identical BcrA ATP-binding subunits and one each of the integral membrane proteins, BcrB and BcrC. B. subtilis cells carrying bcr genes on high-copy number plasmids develop collateral detergent sensitivity, a similar phenomenon in human cells with overexpressed multi-drug resistance P-glycoprotein.

Pssm-ID: 213235 [Multi-domain] Cd Length: 208 Bit Score: 100.75 E-value: 2.54e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTFrrGGKavKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGtliEGGMTVDGHDIMSLSNrALS 88
Cdd:cd03268    1 LKTNDLTKTY--GKK--RVLDDISLHVKKGEIYGFLGPNGAGKTTTMKIILGLIKPD---SGEITFDGKSYQKNIE-ALR 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  89 DLrGAVVSM-VFQEPRLALDPVYTVGRQIeetIMRHEKVSR-----GLAAeralalfqkvripSPERRLSNYphemSGGM 162
Cdd:cd03268   73 RI-GALIEApGFYPNLTARENLRLLARLL---GIRKKRIDEvldvvGLKD-------------SAKKKVKGF----SLGM 131

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 523689182 163 LQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELqREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEG 240
Cdd:cd03268  132 KQRLGIALALLGNPDLLILDEPTNGLDPDGIKELRELILSL-RDQGITVLISSHLLSEIQKVADRIGIINKGKLIEEG 208

PRK10584

putative ABC transporter ATP-binding protein YbbA; Provisional

3-239

2.92e-25

putative ABC transporter ATP-binding protein YbbA; Provisional

Pssm-ID: 182569 [Multi-domain] Cd Length: 228 Bit Score: 101.01 E-value: 2.92e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   3 MQNDAMIDISNLSVTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGtliEGGMTVDGHDIMSL 82
Cdd:PRK10584   1 MPAENIVEVHHLKKSVGQGEHELSILTGVELVVKRGETIALIGESGSGKSTLLAILAGLDDGS---SGEVSLVGQPLHQM 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  83 SNRALSDLRGAVVSMVFQEprLALDPVYTVGRQIE-ETIMRHEkvSRGLAAERALALFQKVRIpspERRLSNYPHEMSGG 161
Cdd:PRK10584  78 DEEARAKLRAKHVGFVFQS--FMLIPTLNALENVElPALLRGE--SSRQSRNGAKALLEQLGL---GKRLDHLPAQLSGG 150

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 523689182 162 MLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEvADRIAVMYAGRIVEE 239
Cdd:PRK10584 151 EQQRVALARAFNGRPDVLFADEPTGNLDRQTGDKIADLLFSLNREHGTTLILVTHDLQLAAR-CDRRLRLVNGQLQEE 227

ABCC_ATM1_transporter

cd03253

ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; ATM1 is an ABC ...

26-240

3.91e-25

ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; ATM1 is an ABC transporter that is expressed in the mitochondria. Although the specific function of ATM1 is unknown, its disruption results in the accumulation of excess mitochondrial iron, loss of mitochondrial cytochromes, oxidative damage to mitochondrial DNA, and decreased levels of cytosolic heme proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213220 [Multi-domain] Cd Length: 236 Bit Score: 100.77 E-value: 3.91e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  26 KAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHpkgTLIEGGMTVDGHDIMSLSnraLSDLRGAvVSMVFQEPRLA 105
Cdd:cd03253   15 PVLKDVSFTIPAGKKVAIVGPSGSGKSTILRLLFRFY---DVSSGSILIDGQDIREVT---LDSLRRA-IGVVPQDTVLF 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 106 LDPV-YTV--GR---------------QIEETIMRHEKVSRGLAAERALALfqkvripsperrlsnyphemSGGMLQRAM 167
Cdd:cd03253   88 NDTIgYNIryGRpdatdeevieaakaaQIHDKIMRFPDGYDTIVGERGLKL--------------------SGGEKQRVA 147

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 523689182 168 IAMALACNPKVLLADEPTTALDATVQIQILLLIRELQReyGLSVIFVTHDIGVAAEvADRIAVMYAGRIVEEG 240
Cdd:cd03253  148 IARAILKNPPILLLDEATSALDTHTEREIQAALRDVSK--GRTTIVIAHRLSTIVN-ADKIIVLKDGRIVERG 217

ABC_FtsE

cd03292

Cell division ATP-binding protein FtsE; The FtsEX complex resembles an ABC transporter, where ...

25-236

5.56e-25

Cell division ATP-binding protein FtsE; The FtsEX complex resembles an ABC transporter, where FtsE is the ATPase and the membrane subunit FtsX resembles a permease subunit. But rather than transporting any substrate, the complex acts in cell division by undergoing conformational changes that alter the activity of cell wall hydrolases located outside the plasma membrane. The complex is widely conserved in bacteria, but also extremely divergent in sequence between different lineages

Pssm-ID: 213259 [Multi-domain] Cd Length: 214 Bit Score: 100.17 E-value: 5.56e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  25 VKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLH-PKGTLIEggmtVDGHDIMSLSNRALSDLRGAVvSMVFQEPR 103
Cdd:cd03292   14 TAALDGINISISAGEFVFLVGPSGAGKSTLLKLIYKEElPTSGTIR----VNGQDVSDLRGRAIPYLRRKI-GVVFQDFR 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 104 LALDpvytvgRQIEETI---MRHEKVSRGLAAERALALFQKVRIPSPERrlsNYPHEMSGGMLQRAMIAMALACNPKVLL 180
Cdd:cd03292   89 LLPD------RNVYENVafaLEVTGVPPREIRKRVPAALELVGLSHKHR---ALPAELSGGEQQRVAIARAIVNSPTILI 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 523689182 181 ADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAGRI 236
Cdd:cd03292  160 ADEPTGNLDPDTTWEIMNLLKKINKA-GTTVVVATHAKELVDTTRHRVIALERGKL 214

PRK10575

Fe3+-hydroxamate ABC transporter ATP-binding protein FhuC;

15-249

8.93e-25

Fe3+-hydroxamate ABC transporter ATP-binding protein FhuC;

Pssm-ID: 182561 [Multi-domain] Cd Length: 265 Bit Score: 100.63 E-value: 8.93e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  15 SVTFRRGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGtliEGGMTVDGHDIMSLSNRALSDLRGAV 94
Cdd:PRK10575  16 NVSFRVPGRTL--LHPLSLTFPAGKVTGLIGHNGSGKSTLLKMLGRHQPPS---EGEILLDAQPLESWSSKAFARKVAYL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  95 VSMVFQEPRLALDPVYTVGRqieetIMRHEKVSRGLAAER-----ALALfqkVRIPSPERRLSNyphEMSGGMLQRAMIA 169
Cdd:PRK10575  91 PQQLPAAEGMTVRELVAIGR-----YPWHGALGRFGAADRekveeAISL---VGLKPLAHRLVD---SLSGGERQRAWIA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 170 MALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDIIRNP 249
Cdd:PRK10575 160 MLVAQDSRCLLLDEPTSALDIAHQVDVLALVHRLSQERGLTVIAVLHDINMAARYCDYLVALRGGEMIAQGTPAELMRGE 239

PRK14258

phosphate ABC transporter ATP-binding protein; Provisional

9-262

9.16e-25

phosphate ABC transporter ATP-binding protein; Provisional

Pssm-ID: 184593 [Multi-domain] Cd Length: 261 Bit Score: 100.50 E-value: 9.16e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTFrrggKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPkgtlIEGGMTVDGHdiMSLSNRALS 88
Cdd:PRK14258   8 IKVNNLSFYY----DTQKILEGVSMEIYQSKVTAIIGPSGCGKSTFLKCLNRMNE----LESEVRVEGR--VEFFNQNIY 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  89 DLRGAV------VSMVFQEPRLALDPVYTVGRQIEETIMRHEKVSRGLAAERALA---LFQKVRipspeRRLSNYPHEMS 159
Cdd:PRK14258  78 ERRVNLnrlrrqVSMVHPKPNLFPMSVYDNVAYGVKIVGWRPKLEIDDIVESALKdadLWDEIK-----HKIHKSALDLS 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 160 GGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYA-----G 234
Cdd:PRK14258 153 GGQQQRLCIARALAVKPKVLLMDEPCFGLDPIASMKVESLIQSLRLRSELTMVIVSHNLHQVSRLSDFTAFFKGnenriG 232

                        250       260
                 ....*....|....*....|....*...
gi 523689182 235 RIVEEGLVGDIIRNPRHPYTKGLLGARV 262
Cdd:PRK14258 233 QLVEFGLTKKIFNSPHDSRTREYVLSRL 260

lolD

PRK11629

lipoprotein-releasing ABC transporter ATP-binding protein LolD;

5-239

9.87e-25

lipoprotein-releasing ABC transporter ATP-binding protein LolD;

Pssm-ID: 183244 [Multi-domain] Cd Length: 233 Bit Score: 99.89 E-value: 9.87e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   5 NDAMIDISNLSVTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTmrsllrLHPKGTL---IEGGMTVDGHDIMS 81
Cdd:PRK11629   2 NKILLQCDNLCKRYQEGSVQTDVLHNVSFSIGEGEMMAIVGSSGSGKSTL------LHLLGGLdtpTSGDVIFNGQPMSK 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  82 LSNRALSDLRGAVVSMVFQEPRLAldPVYTVgrqIEETIMRH--EKVSRGLAAERALALFQKVRIpspERRLSNYPHEMS 159
Cdd:PRK11629  76 LSSAAKAELRNQKLGFIYQFHHLL--PDFTA---LENVAMPLliGKKKPAEINSRALEMLAAVGL---EHRANHRPSELS 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 160 GGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVaDRIAVMYAGRIVEE 239
Cdd:PRK11629 148 GGERQRVAIARALVNNPRLVLADEPTGNLDARNADSIFQLLGELNRLQGTAFLVVTHDLQLAKRM-SRQLEMRDGRLTAE 226

ABC_putative_ATPase

cd03269

ATP-binding cassette domain of an uncharacterized transporter; This subgroup is related to the ...

9-240

9.88e-25

ATP-binding cassette domain of an uncharacterized transporter; This subgroup is related to the subfamily A transporters involved in drug resistance, nodulation, lipid transport, and bacteriocin and lantibiotic immunity. In eubacteria and archaea, the typical organization consists of one ABC and one or two integral membranes. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region in addition to the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213236 [Multi-domain] Cd Length: 210 Bit Score: 99.28 E-value: 9.88e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTFRRggkaVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGtliEGGMTVDGHDIMSLSNRALS 88
Cdd:cd03269    1 LEVENVTKRFGR----VTALDDISFSVEKGEIFGLLGPNGAGKTTTIRMILGIILPD---SGEVLFDGKPLDIAARNRIG 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  89 DL---RGavvsmvfqeprlaLDPVYTVGRQieetiMRHEKVSRGL----AAERALALFQKVRI-PSPERRLSnyphEMSG 160
Cdd:cd03269   74 YLpeeRG-------------LYPKMKVIDQ-----LVYLAQLKGLkkeeARRRIDEWLERLELsEYANKRVE----ELSK 131

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 161 GMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEG 240
Cdd:cd03269  132 GNQQKVQFIAAVIHDPELLILDEPFSGLDPVNVELLKDVIRELARA-GKTVILSTHQMELVEELCDRVLLLNKGRAVLYG 210

cbiO

PRK13649

energy-coupling factor transporter ATPase;

9-245

1.18e-24

energy-coupling factor transporter ATPase;

Pssm-ID: 184208 [Multi-domain] Cd Length: 280 Bit Score: 100.59 E-value: 1.18e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTFRRGGK-AVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHpkgTLIEGGMTVDGHDIMSLS-NRA 86
Cdd:PRK13649   3 INLQNVSYTYQAGTPfEGRALFDVNLTIEDGSYTAFIGHTGSGKSTIMQLLNGLH---VPTQGSVRVDDTLITSTSkNKD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  87 LSDLRGAVvSMVFQEPRLALdpvytvgrqIEETIMR-------HEKVSRGLAAERALALFQKVRIPspERRLSNYPHEMS 159
Cdd:PRK13649  80 IKQIRKKV-GLVFQFPESQL---------FEETVLKdvafgpqNFGVSQEEAEALAREKLALVGIS--ESLFEKNPFELS 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 160 GGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEE 239
Cdd:PRK13649 148 GGQMRRVAIAGILAMEPKILVLDEPTAGLDPKGRKELMTLFKKLHQS-GMTIVLVTHLMDDVANYADFVYVLEKGKLVLS 226


                 ....*.
gi 523689182 240 GLVGDI 245
Cdd:PRK13649 227 GKPKDI 232

ABC_drug_resistance_like

cd03264

ABC-type multidrug transport system, ATPase component; The biological function of this family ...

9-240

1.18e-24

ABC-type multidrug transport system, ATPase component; The biological function of this family is not well characterized, but display ABC domains similar to members of ABCA subfamily. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213231 [Multi-domain] Cd Length: 211 Bit Score: 99.19 E-value: 1.18e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTFRRGgkavKAVNGVSLSVKPGeVVALLGESGSGKSVTMRSLLRLHPKGtliEGGMTVDGHDIMslsnRALS 88
Cdd:cd03264    1 LQLENLTKRYGKK----RALDGVSLTLGPG-MYGLLGPNGAGKTTLMRILATLTPPS---SGTIRIDGQDVL----KQPQ 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  89 DLRgAVVSMVFQEPRLalDPVYTVGRQIEeTIMRHEKVSRGLAAERALALFQKVRIpspERRLSNYPHEMSGGMLQRAMI 168
Cdd:cd03264   69 KLR-RRIGYLPQEFGV--YPNFTVREFLD-YIAWLKGIPSKEVKARVDEVLELVNL---GDRAKKKIGSLSGGMRRRVGI 141

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 523689182 169 AMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYglSVIFVTHDIGVAAEVADRIAVMYAGRIVEEG 240
Cdd:cd03264  142 AQALVGDPSILIVDEPTAGLDPEERIRFRNLLSELGEDR--IVILSTHIVEDVESLCNQVAVLNKGKLVFEG 211

ModF

COG1119

ABC-type molybdenum transport system, ATPase component ModF/photorepair protein PhrA ...

6-246

1.56e-24

ABC-type molybdenum transport system, ATPase component ModF/photorepair protein PhrA [Inorganic ion transport and metabolism];

Pssm-ID: 440736 [Multi-domain] Cd Length: 250 Bit Score: 99.77 E-value: 1.56e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   6 DAMIDISNlsVTFRRGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSvtmrSLLRL----HPKGTliegGMTVD--GHDI 79
Cdd:COG1119    1 DPLLELRN--VTVRRGGKTI--LDDISWTVKPGEHWAILGPNGAGKS----TLLSLitgdLPPTY----GNDVRlfGERR 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  80 MSLSnraLSDLRG--AVVSmvfqePRLALD-PVYTVGRQI-----EETIMRHEKVSRgLAAERALALFQKVRIpspeRRL 151
Cdd:COG1119   69 GGED---VWELRKriGLVS-----PALQLRfPRDETVLDVvlsgfFDSIGLYREPTD-EQRERARELLELLGL----AHL 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 152 SNYP-HEMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAV 230
Cdd:COG1119  136 ADRPfGTLSQGEQRRVLIARALVKDPELLILDEPTAGLDLGARELLLALLDKLAAEGAPTLVLVTHHVEEIPPGITHVLL 215

                        250
                 ....*....|....*.
gi 523689182 231 MYAGRIVEEGLVGDII 246
Cdd:COG1119  216 LKDGRVVAAGPKEEVL 231

MglA

COG1129

ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism];

26-239

2.36e-24

ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism];

Pssm-ID: 440745 [Multi-domain] Cd Length: 497 Bit Score: 102.79 E-value: 2.36e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  26 KAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKgtlIEGGMTVDGHDIMSLSNRALSDLRGAVVSmvfqEPR-- 103
Cdd:COG1129  266 GVVRDVSFSVRAGEILGIAGLVGAGRTELARALFGADPA---DSGEIRLDGKPVRIRSPRDAIRAGIAYVP----EDRkg 338

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 104 --LALDpvytvgRQIEE--TIMRHEKVSRGL----AAERALA--LFQKVRI--PSPERRLSNypheMSGGMLQRAMIAMA 171
Cdd:COG1129  339 egLVLD------LSIREniTLASLDRLSRGGlldrRRERALAeeYIKRLRIktPSPEQPVGN----LSGGNQQKVVLAKW 408

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 523689182 172 LACNPKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEE 239
Cdd:COG1129  409 LATDPKVLILDEPTRGIDVGAKAEIYRLIRELAAE-GKAVIVISSELPELLGLSDRILVMREGRIVGE 475

ABCC_MsbA

cd03251

ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; ...

15-240

3.08e-24

ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213218 [Multi-domain] Cd Length: 234 Bit Score: 98.46 E-value: 3.08e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  15 SVTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHpkgTLIEGGMTVDGHDIMSLSnraLSDLRgAV 94
Cdd:cd03251    5 NVTFRYPGDGPPVLRDISLDIPAGETVALVGPSGSGKSTLVNLIPRFY---DVDSGRILIDGHDVRDYT---LASLR-RQ 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  95 VSMVFQEPRLALDPV-----YTVGRQIEETIMRhekvsrglAAERALALFQKVRIPS------PERRLSnypheMSGGML 163
Cdd:cd03251   78 IGLVSQDVFLFNDTVaeniaYGRPGATREEVEE--------AARAANAHEFIMELPEgydtviGERGVK-----LSGGQR 144

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 523689182 164 QRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQReyGLSVIFVTHDIGvAAEVADRIAVMYAGRIVEEG 240
Cdd:cd03251  145 QRIAIARALLKDPPILILDEATSALDTESERLVQAALERLMK--NRTTFVIAHRLS-TIENADRIVVLEDGKIVERG 218

ssuB

PRK11247

aliphatic sulfonates transport ATP-binding subunit; Provisional

15-279

3.38e-24

aliphatic sulfonates transport ATP-binding subunit; Provisional

Pssm-ID: 183055 [Multi-domain] Cd Length: 257 Bit Score: 98.98 E-value: 3.38e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  15 SVTFRRGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRL-HPK-GTLIEGgmtvdghdimslsNRALSDLRG 92
Cdd:PRK11247  17 AVSKRYGERTV--LNQLDLHIPAGQFVAVVGRSGCGKSTLLRLLAGLeTPSaGELLAG-------------TAPLAEARE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  93 AVvSMVFQEPRLAldPVYTVgrqieetimrHEKVSRGL------AAERALAlfqKVRIpspERRLSNYPHEMSGGMLQRA 166
Cdd:PRK11247  82 DT-RLMFQDARLL--PWKKV----------IDNVGLGLkgqwrdAALQALA---AVGL---ADRANEWPAALSGGQKQRV 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 167 MIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAvmyagrIVEEGLVG--- 243
Cdd:PRK11247 143 ALARALIHRPGLLLLDEPLGALDALTRIEMQDLIESLWQQHGFTVLLVTHDVSEAVAMADRVL------LIEEGKIGldl 216

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 523689182 244 --DIIRnPRHPYTKGLlgARVElAEGRDRLVTIPGAPP 279
Cdd:PRK11247 217 tvDLPR-PRRRGSARL--AELE-AEVLQRVMSRGESEP 250

COG4586

ABC-type uncharacterized transport system, ATPase component [General function prediction only]; ...

8-248

3.81e-24

ABC-type uncharacterized transport system, ATPase component [General function prediction only];

Pssm-ID: 443643 [Multi-domain] Cd Length: 323 Bit Score: 100.16 E-value: 3.81e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSVTFR-----------------RGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLR-LHP-KGTLi 68
Cdd:COG4586    1 IIEVENLSKTYRvyekepglkgalkglfrREYREVEAVDDISFTIEPGEIVGFIGPNGAGKSTTIKMLTGiLVPtSGEV- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  69 eggmTVDGHDIMSLSNRALSDlrgavVSMVF-QEPRLALDpvytvgrqieetimrhekvsrgLAAERALALFQKV-RIPS 146
Cdd:COG4586   80 ----RVLGYVPFKRRKEFARR-----IGVVFgQRSQLWWD----------------------LPAIDSFRLLKAIyRIPD 128

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 147 PE--RRLsnypHEMSGgMLQ------------------RAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQRE 206
Cdd:COG4586  129 AEykKRL----DELVE-LLDlgelldtpvrqlslgqrmRCELAAALLHRPKILFLDEPTIGLDVVSKEAIREFLKEYNRE 203

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 523689182 207 YGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDIIRN 248
Cdd:COG4586  204 RGTTILLTSHDMDDIEALCDRVIVIDHGRIIYDGSLEELKER 245

PRK10908

cell division ATP-binding protein FtsE;

21-244

4.28e-24

cell division ATP-binding protein FtsE;

Pssm-ID: 182829 [Multi-domain] Cd Length: 222 Bit Score: 98.02 E-value: 4.28e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  21 GGKavKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGTlieGGMTVDGHDIMSLSNRALSDLRGAVvSMVFQ 100
Cdd:PRK10908  13 GGR--QALQGVTFHMRPGEMAFLTGHSGAGKSTLLKLICGIERPSA---GKIWFSGHDITRLKNREVPFLRRQI-GMIFQ 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 101 EPRLALD---------PVYTVGRQiEETIMRheKVSrglAAERALALFQKVRipsperrlsNYPHEMSGGMLQRAMIAMA 171
Cdd:PRK10908  87 DHHLLMDrtvydnvaiPLIIAGAS-GDDIRR--RVS---AALDKVGLLDKAK---------NFPIQLSGGEQQRVGIARA 151

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 523689182 172 LACNPKVLLADEPTTALDATVQIQILLLIRELQReYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVeEGLVGD 244
Cdd:PRK10908 152 VVNKPAVLLADEPTGNLDDALSEGILRLFEEFNR-VGVTVLMATHDIGLISRRSYRMLTLSDGHLH-GGVGGE 222

PRK13657

glucan ABC transporter ATP-binding protein/ permease;

9-240

5.79e-24

glucan ABC transporter ATP-binding protein/ permease;

Pssm-ID: 184214 [Multi-domain] Cd Length: 588 Bit Score: 101.96 E-value: 5.79e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLS-------VTFRRGGKAvKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLH-PKGtlieGGMTVDGHDIM 80
Cdd:PRK13657 326 IDLGRVKgavefddVSFSYDNSR-QGVEDVSFEAKPGQTVAIVGPTGAGKSTLINLLQRVFdPQS----GRILIDGTDIR 400

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  81 SLSnraLSDLRGAvVSMVFQEPRLaldpvytVGRQIEETI------MRHEKVSRglAAERALAL-FQkvripspERRLSN 153
Cdd:PRK13657 401 TVT---RASLRRN-IAVVFQDAGL-------FNRSIEDNIrvgrpdATDEEMRA--AAERAQAHdFI-------ERKPDG 460

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 154 YP-------HEMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQReyGLSVIFVTHDIGVAAEvAD 226
Cdd:PRK13657 461 YDtvvgergRQLSGGERQRLAIARALLKDPPILILDEATSALDVETEAKVKAALDELMK--GRTTFIIAHRLSTVRN-AD 537

                        250
                 ....*....|....
gi 523689182 227 RIAVMYAGRIVEEG 240
Cdd:PRK13657 538 RILVFDNGRVVESG 551

ABCC_Hemolysin

cd03252

ATP-binding cassette domain of hemolysin B, subfamily C; The ABC-transporter hemolysin B is a ...

16-240

8.42e-24

ATP-binding cassette domain of hemolysin B, subfamily C; The ABC-transporter hemolysin B is a central component of the secretion machinery that translocates the toxin, hemolysin A, in a Sec-independent fashion across both membranes of E. coli. The hemolysin A (HlyA) transport machinery is composed of the ATP-binding cassette (ABC) transporter HlyB located in the inner membrane, hemolysin D (HlyD), also anchored in the inner membrane, and TolC, which resides in the outer membrane. HlyD apparently forms a continuous channel that bridges the entire periplasm, interacting with TolC and HlyB. This arrangement prevents the appearance of periplasmic intermediates of HlyA during substrate transport. Little is known about the molecular details of HlyA transport, but it is evident that ATP-hydrolysis by the ABC-transporter HlyB is a necessary source of energy.

Pssm-ID: 213219 [Multi-domain] Cd Length: 237 Bit Score: 97.56 E-value: 8.42e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  16 VTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGtliEGGMTVDGHDIMSLsnrALSDLRgAVV 95
Cdd:cd03252    6 VRFRYKPDGPVILDNISLRIKPGEVVGIVGRSGSGKSTLTKLIQRFYVPE---NGRVLVDGHDLALA---DPAWLR-RQV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  96 SMVFQEPRLaldpvytVGRQIEETI------MRHEKVSRGLAAERALALFQKVRIpSPERRLSNYPHEMSGGMLQRAMIA 169
Cdd:cd03252   79 GVVLQENVL-------FNRSIRDNIaladpgMSMERVIEAAKLAGAHDFISELPE-GYDTIVGEQGAGLSGGQRQRIAIA 150

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 523689182 170 MALACNPKVLLADEPTTALDATVQIQILLLIRELQReyGLSVIFVTHDIGvAAEVADRIAVMYAGRIVEEG 240
Cdd:cd03252  151 RALIHNPRILIFDEATSALDYESEHAIMRNMHDICA--GRTVIIIAHRLS-TVKNADRIIVMEKGRIVEQG 218

xylG

TIGR02633

D-xylose ABC transporter, ATP-binding protein; Several bacterial species have enzymes xylose ...

25-237

1.49e-23

D-xylose ABC transporter, ATP-binding protein; Several bacterial species have enzymes xylose isomerase and xylulokinase enzymes for xylose utilization. Members of this protein family are the ATP-binding cassette (ABC) subunit of the known or predicted high-affinity xylose ABC transporter for xylose import. These genes, which closely resemble other sugar transport ABC transporter genes, typically are encoded near xylose utilization enzymes and regulatory proteins. Note that this form of the transporter contains two copies of the ABC transporter domain (pfam00005). [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]

Pssm-ID: 131681 [Multi-domain] Cd Length: 500 Bit Score: 100.67 E-value: 1.49e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   25 VKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGTLiEGGMTVDGHDIMSlsnRALSDLRGAVVSMVFQEprL 104
Cdd:TIGR02633  14 VKALDGIDLEVRPGECVGLCGENGAGKSTLMKILSGVYPHGTW-DGEIYWSGSPLKA---SNIRDTERAGIVIIHQE--L 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  105 ALDPVYTVgrqIEETIMRHEKVSRG------LAAERALALFQKVRIP-SPERRLSNyphEMSGGMLQRAMIAMALACNPK 177
Cdd:TIGR02633  88 TLVPELSV---AENIFLGNEITLPGgrmaynAMYLRAKNLLRELQLDaDNVTRPVG---DYGGGQQQLVEIAKALNKQAR 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 523689182  178 VLLADEPTTALDATvQIQILL-LIRELQReYGLSVIFVTHDIGVAAEVADRIAVMYAGRIV 237
Cdd:TIGR02633 162 LLILDEPSSSLTEK-ETEILLdIIRDLKA-HGVACVYISHKLNEVKAVCDTICVIRDGQHV 220

modC_ABC

TIGR02142

molybdenum ABC transporter, ATP-binding protein; This model represents the ATP-binding ...

31-253

1.71e-23

molybdenum ABC transporter, ATP-binding protein; This model represents the ATP-binding cassette (ABC) protein of the three subunit molybdate ABC transporter. The three proteins of this complex are homologous to proteins of the sulfate ABC transporter. Molybdenum may be used in nitrogenases of nitrogen-fixing bacteria and in molybdopterin cofactors. In some cases, molybdate may be transported by a sulfate transporter rather than by a specific molybdate transporter. [Transport and binding proteins, Anions]

Pssm-ID: 131197 [Multi-domain] Cd Length: 354 Bit Score: 99.03 E-value: 1.71e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   31 VSLSVKPGEVVALLGESGSGKSvtmrSLLRLhpkgtlIEGGMTVDGHDImSLSNRALSDLRGAV--------VSMVFQEP 102
Cdd:TIGR02142  16 ADFTLPGQGVTAIFGRSGSGKT----TLIRL------IAGLTRPDEGEI-VLNGRTLFDSRKGIflppekrrIGYVFQEA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  103 RLAldPVYTVGRQIEETIMRHEKVSRGLAAERALALFqkvripSPERRLSNYPHEMSGGMLQRAMIAMALACNPKVLLAD 182
Cdd:TIGR02142  85 RLF--PHLSVRGNLRYGMKRARPSERRISFERVIELL------GIGHLLGRLPGRLSGGEKQRVAIGRALLSSPRLLLMD 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 523689182  183 EPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDIIRNPRHPY 253
Cdd:TIGR02142 157 EPLAALDDPRKYEILPYLERLHAEFGIPILYVSHSLQEVLRLADRVVVLEDGRVAAAGPIAEVWASPDLPW 227

ABC_Carb_Monos_II

cd03215

Second domain of the ATP-binding cassette component of monosaccharide transport system; This ...

5-236

2.59e-23

Second domain of the ATP-binding cassette component of monosaccharide transport system; This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (such as xylose, arabinose, and ribose), that cannot be broken down to simple sugars by hydrolysis. In members of Carb_Monos family the single hydrophobic gene product forms a homodimer, while the ABC protein represents a fusion of two nucleotide-binding domains. However, it is assumed that two copies of the ABC domains are present in the assembled transporter.

Pssm-ID: 213182 [Multi-domain] Cd Length: 182 Bit Score: 94.42 E-value: 2.59e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   5 NDAMIDISNLSVTfrrggkavKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPkgtLIEGGMTVDGHDIMSLSN 84
Cdd:cd03215    1 GEPVLEVRGLSVK--------GAVRDVSFEVRAGEIVGIAGLVGNGQTELAEALFGLRP---PASGEITLDGKPVTRRSP 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  85 RALSDLRGAVVSmvfqeprlaldpvytvgrqiEEtimRHEkvsRGLAAERALAlfQKVRIPspeRRLSnyphemsGGMLQ 164
Cdd:cd03215   70 RDAIRAGIAYVP--------------------ED---RKR---EGLVLDLSVA--ENIALS---SLLS-------GGNQQ 111

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 523689182 165 RAMIAMALACNPKVLLADEPTTALD-ATVQiQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAGRI 236
Cdd:cd03215  112 KVVLARWLARDPRVLILDEPTRGVDvGAKA-EIYRLIRELADA-GKAVLLISSELDELLGLCDRILVMYEGRI 182

cbiO

PRK13636

cobalt transporter ATP-binding subunit; Provisional

27-240

2.95e-23

cobalt transporter ATP-binding subunit; Provisional

Pssm-ID: 184196 [Multi-domain] Cd Length: 283 Bit Score: 96.84 E-value: 2.95e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  27 AVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLR-LHP-KGTLIEGGMTVDghdimsLSNRALSDLRGAvVSMVFQEP-- 102
Cdd:PRK13636  21 ALKGININIKKGEVTAILGGNGAGKSTLFQNLNGiLKPsSGRILFDGKPID------YSRKGLMKLRES-VGMVFQDPdn 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 103 RLALDPVY------TVGRQIEETIMrHEKVSRGLAAERALALFQKvriPSperrlsnypHEMSGGMLQRAMIAMALACNP 176
Cdd:PRK13636  94 QLFSASVYqdvsfgAVNLKLPEDEV-RKRVDNALKRTGIEHLKDK---PT---------HCLSFGQKKRVAIAGVLVMEP 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 523689182 177 KVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEG 240
Cdd:PRK13636 161 KVLVLDEPTAGLDPMGVSEIMKLLVEMQKELGLTIIIATHDIDIVPLYCDNVFVMKEGRVILQG 224

hmuV

PRK13547

heme ABC transporter ATP-binding protein;

8-279

3.11e-23

heme ABC transporter ATP-binding protein;

Pssm-ID: 184132 [Multi-domain] Cd Length: 272 Bit Score: 96.82 E-value: 3.11e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSVtFRRGGKAVKAVngvSLSVKPGEVVALLGESGSGKSVTMRSLL-----RLHPKGTLIEGGMTVDGHDIMSL 82
Cdd:PRK13547   1 MLTADHLHV-ARRHRAILRDL---SLRIEPGRVTALLGRNGAGKSTLLKALAgdltgGGAPRGARVTGDVTLNGEPLAAI 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  83 SNRALSDLRGAVVSMVFQEPRLALDPVYTVGRQIEETIMRHEKVSRGLAAERALALFQKVriPSPERRLSNypheMSGGM 162
Cdd:PRK13547  77 DAPRLARLRAVLPQAAQPAFAFSAREIVLLGRYPHARRAGALTHRDGEIAWQALALAGAT--ALVGRDVTT----LSGGE 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 163 LQRAMIAMALA---------CNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYA 233
Cdd:PRK13547 151 LARVQFARVLAqlwpphdaaQPPRYLLLDEPTAALDLAHQHRLLDTVRRLARDWNLGVLAIVHDPNLAARHADRIAMLAD 230

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 523689182 234 GRIVEEGLVGDIIRnPRHpyTKGLLGARVELAEGRDrlvtipGAPP 279
Cdd:PRK13547 231 GAIVAHGAPADVLT-PAH--IARCYGFAVRLVDAGD------GVPP 267

PRK14243

phosphate transporter ATP-binding protein; Provisional

4-261

3.36e-23

phosphate transporter ATP-binding protein; Provisional

Pssm-ID: 184588 [Multi-domain] Cd Length: 264 Bit Score: 96.39 E-value: 3.36e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   4 QNDAMIDISNLSVTFrrgGKAVkAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHP--KGTLIEGGMTVDGHDIMS 81
Cdd:PRK14243   6 GTETVLRTENLNVYY---GSFL-AVKNVWLDIPKNQITAFIGPSGCGKSTILRCFNRLNDliPGFRVEGKVTFHGKNLYA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  82 lSNRALSDLRGAVvSMVFQEPrlaldpvYTVGRQIEETIM-----------RHEKVSRGLaaeRALALFQKVRIPSPERR 150
Cdd:PRK14243  82 -PDVDPVEVRRRI-GMVFQKP-------NPFPKSIYDNIAygaringykgdMDELVERSL---RQAALWDEVKDKLKQSG 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 151 LSnypheMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYglSVIFVTHDIGVAAEVADRIAV 230
Cdd:PRK14243 150 LS-----LSGGQQQRLCIARAIAVQPEVILMDEPCSALDPISTLRIEELMHELKEQY--TIIIVTHNMQQAARVSDMTAF 222

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 523689182 231 MYA---------GRIVEEGLVGDIIRNPRHPYTKGLLGAR 261
Cdd:PRK14243 223 FNVeltegggryGYLVEFDRTEKIFNSPQQQATRDYVSGR 262

CcmA

COG4133

ABC-type transport system involved in cytochrome c biogenesis, ATPase component ...

7-217

4.46e-23

ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones];

Pssm-ID: 443308 [Multi-domain] Cd Length: 206 Bit Score: 94.47 E-value: 4.46e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   7 AMIDISNLSVtfRRGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSvtmrSLLR-----LHPkgtlIEGGMTVDGHDIms 81
Cdd:COG4133    1 MMLEAENLSC--RRGERLL--FSGLSFTLAAGEALALTGPNGSGKT----TLLRilaglLPP----SAGEVLWNGEPI-- 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  82 lsNRALSDLRGAvvsMVFQEPRLALDPVYTVGRQIEETIMRHEKVSRGLAAERALALFQkvripsPERRLSNYPHEMSGG 161
Cdd:COG4133   67 --RDAREDYRRR---LAYLGHADGLKPELTVRENLRFWAALYGLRADREAIDEALEAVG------LAGLADLPVRQLSAG 135

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 523689182 162 MLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRElQREYGLSVIFVTHD 217
Cdd:COG4133  136 QKRRVALARLLLSPAPLWLLDEPFTALDAAGVALLAELIAA-HLARGGAVLLTTHQ 190

cbiO

PRK13647

cobalt transporter ATP-binding subunit; Provisional

6-240

8.38e-23

cobalt transporter ATP-binding subunit; Provisional

Pssm-ID: 237457 [Multi-domain] Cd Length: 274 Bit Score: 95.57 E-value: 8.38e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   6 DAMIDISNLSVTFRRGGKAVKavnGVSLSVKPGEVVALLGESGSGKSVtmrslLRLHPKG--TLIEGGMTVDGHDImslS 83
Cdd:PRK13647   2 DNIIEVEDLHFRYKDGTKALK---GLSLSIPEGSKTALLGPNGAGKST-----LLLHLNGiyLPQRGRVKVMGREV---N 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  84 NRALSDLRGAVvSMVFQEPR-----------LALDPVyTVGRQIEETimrHEKVSRGLAAERALALFQKVripsperrls 152
Cdd:PRK13647  71 AENEKWVRSKV-GLVFQDPDdqvfsstvwddVAFGPV-NMGLDKDEV---ERRVEEALKAVRMWDFRDKP---------- 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 153 nyPHEMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMY 232
Cdd:PRK13647 136 --PYHLSYGQKKRVAIAGVLAMDPDVIVLDEPMAYLDPRGQETLMEILDRLHNQ-GKTVIVATHDVDLAAEWADQVIVLK 212


                 ....*...
gi 523689182 233 AGRIVEEG 240
Cdd:PRK13647 213 EGRVLAEG 220

ABCC_bacteriocin_exporters

cd03245

ATP-binding cassette domain of bacteriocin exporters, subfamily C; Many non-lantibiotic ...

16-240

1.16e-22

ATP-binding cassette domain of bacteriocin exporters, subfamily C; Many non-lantibiotic bacteriocins of lactic acid bacteria are produced as precursors which have N-terminal leader peptides that share similarities in amino acid sequence and contain a conserved processing site of two glycine residues in positions -1 and -2. A dedicated ATP-binding cassette (ABC) transporter is responsible for the proteolytic cleavage of the leader peptides and subsequent translocation of the bacteriocins across the cytoplasmic membrane.

Pssm-ID: 213212 [Multi-domain] Cd Length: 220 Bit Score: 93.81 E-value: 1.16e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  16 VTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGtliEGGMTVDGHDIMSLSnraLSDLRgAVV 95
Cdd:cd03245    8 VSFSYPNQEIPALDNVSLTIRAGEKVAIIGRVGSGKSTLLKLLAGLYKPT---SGSVLLDGTDIRQLD---PADLR-RNI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  96 SMVFQEPRLALDPVY---TVGRQI--EETIMRhekvsrglAAERA-LALFQKVRIPSPERRLSNYPHEMSGGMLQRAMIA 169
Cdd:cd03245   81 GYVPQDVTLFYGTLRdniTLGAPLadDERILR--------AAELAgVTDFVNKHPNGLDLQIGERGRGLSGGQRQAVALA 152

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 523689182 170 MALACNPKVLLADEPTTALDATVQIQILLLIRELQReyGLSVIFVTHDIgVAAEVADRIAVMYAGRIVEEG 240
Cdd:cd03245  153 RALLNDPPILLLDEPTSAMDMNSEERLKERLRQLLG--DKTLIIITHRP-SLLDLVDRIIVMDSGRIVADG 220

PRK14246

phosphate ABC transporter ATP-binding protein; Provisional

31-262

1.22e-22

phosphate ABC transporter ATP-binding protein; Provisional

Pssm-ID: 172734 [Multi-domain] Cd Length: 257 Bit Score: 94.73 E-value: 1.22e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  31 VSLSVKPGEVVALLGESGSGKSVTMRSLLRL---HPKGTLIEGGMTVDGHDIMSLSNRALSDlrgaVVSMVFQEPRL--A 105
Cdd:PRK14246  29 ITIKIPNNSIFGIMGPSGSGKSTLLKVLNRLieiYDSKIKVDGKVLYFGKDIFQIDAIKLRK----EVGMVFQQPNPfpH 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 106 LDPVYTVGRQIEETIMRHEKVSRGLAAE--RALALFQKVRipspeRRLSNYPHEMSGGMLQRAMIAMALACNPKVLLADE 183
Cdd:PRK14246 105 LSIYDNIAYPLKSHGIKEKREIKKIVEEclRKVGLWKEVY-----DRLNSPASQLSGGQQQRLTIARALALKPKVLLMDE 179

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 523689182 184 PTTALDATVQIQILLLIRELQREygLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDIIRNPRHPYTKGLLGARV 262
Cdd:PRK14246 180 PTSMIDIVNSQAIEKLITELKNE--IAIVIVSHNPQQVARVADYVAFLYNGELVEWGSSNEIFTSPKNELTEKYVIGRI 256

ugpC

PRK11650

sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC;

7-236

1.41e-22

sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC;

Pssm-ID: 236947 [Multi-domain] Cd Length: 356 Bit Score: 96.45 E-value: 1.41e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   7 AMIDISNLSVTFrrGGKaVKAVNGVSLSVKPGEVVALLGESGSGKSvtmrSLLRLhpkgtlIEGGMTVDGHDImSLSNRA 86
Cdd:PRK11650   2 AGLKLQAVRKSY--DGK-TQVIKGIDLDVADGEFIVLVGPSGCGKS----TLLRM------VAGLERITSGEI-WIGGRV 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  87 LSDL----RGavVSMVFQEprLALDPVYTVgRQIEETIMRHEKVSRGLAAERALALFQKVRI-PSPERRlsnyPHEMSGG 161
Cdd:PRK11650  68 VNELepadRD--IAMVFQN--YALYPHMSV-RENMAYGLKIRGMPKAEIEERVAEAARILELePLLDRK----PRELSGG 138

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 523689182 162 mlQRAMIAM--ALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRI 236
Cdd:PRK11650 139 --QRQRVAMgrAIVREPAVFLFDEPLSNLDAKLRVQMRLEIQRLHRRLKTTSLYVTHDQVEAMTLADRVVVMNGGVA 213

ABCC_MRP_domain2

cd03244

ATP-binding cassette domain 2 of multidrug resistance-associated protein; The ABC subfamily C ...

9-240

1.43e-22

ATP-binding cassette domain 2 of multidrug resistance-associated protein; The ABC subfamily C is also known as MRP (multidrug resistance-associated protein). Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional membrane-spanning domains is not clear. The MRP was found in the multidrug-resistance lung cancer cell in which p-glycoprotein was not overexpressed. MRP exports glutathione by drug stimulation, as well as, certain substrates in conjugated forms with anions, such as glutathione, glucuronate, and sulfate.

Pssm-ID: 213211 [Multi-domain] Cd Length: 221 Bit Score: 93.71 E-value: 1.43e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTFRRGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPkgtLIEGGMTVDGHDIMSLSnraLS 88
Cdd:cd03244    3 IEFKNVSLRYRPNLPPV--LKNISFSIKPGEKVGIVGRTGSGKSSLLLALFRLVE---LSSGSILIDGVDISKIG---LH 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  89 DLRGAvVSMVFQEP-------RLALDPvytVGRQIEETIMrhekvsrglaaeRALALFQ-KVRIPSPERRLsNYPHEMSG 160
Cdd:cd03244   75 DLRSR-ISIIPQDPvlfsgtiRSNLDP---FGEYSDEELW------------QALERVGlKEFVESLPGGL-DTVVEEGG 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 161 GML---QRAMIAMALAC--NPKVLLADEPTTALDatvqIQILLLIRELQREY--GLSVIFVTHDIGVAAEvADRIAVMYA 233
Cdd:cd03244  138 ENLsvgQRQLLCLARALlrKSKILVLDEATASVD----PETDALIQKTIREAfkDCTVLTIAHRLDTIID-SDRILVLDK 212


                 ....*..
gi 523689182 234 GRIVEEG 240
Cdd:cd03244  213 GRVVEFD 219

cbiO

PRK13631

cobalt transporter ATP-binding subunit; Provisional

3-249

2.25e-22

cobalt transporter ATP-binding subunit; Provisional

Pssm-ID: 237451 [Multi-domain] Cd Length: 320 Bit Score: 95.30 E-value: 2.25e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   3 MQNDAMIDISNLSVTF-RRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKS--VTMRSLLRLHPKGTlIEGGMTVDGHDI 79
Cdd:PRK13631  16 LSDDIILRVKNLYCVFdEKQENELVALNNISYTFEKNKIYFIIGNSGSGKStlVTHFNGLIKSKYGT-IQVGDIYIGDKK 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  80 MSLSN---------RALSDLRgAVVSMVFQEPRLALdpvytVGRQIEETIMrHEKVSRGLAAERA--LALFQKVRIPSPE 148
Cdd:PRK13631  95 NNHELitnpyskkiKNFKELR-RRVSMVFQFPEYQL-----FKDTIEKDIM-FGPVALGVKKSEAkkLAKFYLNKMGLDD 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 149 RRLSNYPHEMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRI 228
Cdd:PRK13631 168 SYLERSPFGLSGGQKRRVAIAGILAIQPEILIFDEPTAGLDPKGEHEMMQLILDAKAN-NKTVFVITHTMEHVLEVADEV 246

                        250       260
                 ....*....|....*....|.
gi 523689182 229 AVMYAGRIVEEGLVGDIIRNP 249
Cdd:PRK13631 247 IVMDKGKILKTGTPYEIFTDQ 267

cbiO

PRK13650

energy-coupling factor transporter ATPase;

6-236

2.28e-22

energy-coupling factor transporter ATPase;

Pssm-ID: 184209 [Multi-domain] Cd Length: 279 Bit Score: 94.41 E-value: 2.28e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   6 DAMIDISNLsvTFRRGGKAVK-AVNGVSLSVKPGEVVALLGESGSGKSVTMRsllrlhpkgtLIEGGMTVDGHDIM---- 80
Cdd:PRK13650   2 SNIIEVKNL--TFKYKEDQEKyTLNDVSFHVKQGEWLSIIGHNGSGKSTTVR----------LIDGLLEAESGQIIidgd 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  81 SLSNRALSDLRGAVvSMVFQEPrlalDPVYtVGRQIEETI---MRHEKVSRGLAAERALALFQKVRIPSPERRlsnYPHE 157
Cdd:PRK13650  70 LLTEENVWDIRHKI-GMVFQNP----DNQF-VGATVEDDVafgLENKGIPHEEMKERVNEALELVGMQDFKER---EPAR 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 158 MSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGvaaEVA--DRIAVMYAGR 235
Cdd:PRK13650 141 LSGGQKQRVAIAGAVAMRPKIIILDEATSMLDPEGRLELIKTIKGIRDDYQMTVISITHDLD---EVAlsDRVLVMKNGQ 217


                 .
gi 523689182 236 I 236
Cdd:PRK13650 218 V 218

cbiO

PRK13652

cobalt transporter ATP-binding subunit; Provisional

8-249

4.16e-22

cobalt transporter ATP-binding subunit; Provisional

Pssm-ID: 172200 [Multi-domain] Cd Length: 277 Bit Score: 93.71 E-value: 4.16e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSVTFRrggKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRsllrlHPKGTL--IEGGMTVDGHDImslSNR 85
Cdd:PRK13652   3 LIETRDLCYSYS---GSKEALNNINFIAPRNSRIAVIGPNGAGKSTLFR-----HFNGILkpTSGSVLIRGEPI---TKE 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  86 ALSDLRgAVVSMVFQEPRlalDPVY--TVGRQI----------EETImrHEKVSRGLaaeRALALfqkvripspERRLSN 153
Cdd:PRK13652  72 NIREVR-KFVGLVFQNPD---DQIFspTVEQDIafgpinlgldEETV--AHRVSSAL---HMLGL---------EELRDR 133

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 154 YPHEMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYA 233
Cdd:PRK13652 134 VPHHLSGGEKKRVAIAGVIAMEPQVLVLDEPTAGLDPQGVKELIDFLNDLPETYGMTVIFSTHQLDLVPEMADYIYVMDK 213

                        250
                 ....*....|....*.
gi 523689182 234 GRIVEEGLVGDIIRNP 249
Cdd:PRK13652 214 GRIVAYGTVEEIFLQP 229

CydD

TIGR02857

thiol reductant ABC exporter, CydD subunit; The gene pair cydCD encodes an ABC-family ...

9-231

4.28e-22

thiol reductant ABC exporter, CydD subunit; The gene pair cydCD encodes an ABC-family transporter in which each gene contains an N-terminal membrane-spanning domain (pfam00664) and a C-terminal ATP-binding domain (pfam00005). In E. coli these genes were discovered as mutants which caused the terminal heme-copper oxidase complex cytochrome bd to fail to assemble. Recent work has shown that the transporter is involved in export of redox-active thiol compounds such as cysteine and glutathione. The linkage to assembly of the cytochrome bd complex is further supported by the conserved operon structure found outside the gammaproteobacteria (cydABCD) containing both the transporter and oxidase genes components. The genes used as the seed members for this model are all either found in the gammproteobacterial context or the CydABCD context. All members of this family scoring above trusted at the time of its creation were from genomes which encode a cytochrome bd complex. Unfortunately, the gene symbol nomenclature adopted based on this operon in B. subtilis assigns cydC to the third gene in the operon where this gene is actually homologous to the E. coli cydD gene. We have chosen to name all homologs in this family in accordance with the precedence of publication of the E. coli name, CydD

Pssm-ID: 274323 [Multi-domain] Cd Length: 529 Bit Score: 96.59 E-value: 4.28e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182    9 IDISNLSVTFRRGGKAVKavnGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGtliEGGMTVDGHDIMSLSnralS 88
Cdd:TIGR02857 322 LEFSGVSVAYPGRRPALR---PVSFTVPPGERVALVGPSGAGKSTLLNLLLGFVDPT---EGSIAVNGVPLADAD----A 391

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   89 DLRGAVVSMVFQEPrlaldpvYTVGRQIEETIMRHEKVSRGLAAERALAL-----FQKVRIPSPERRLSNYPHEMSGGML 163
Cdd:TIGR02857 392 DSWRDQIAWVPQHP-------FLFAGTIAENIRLARPDASDAEIREALERagldeFVAALPQGLDTPIGEGGAGLSGGQA 464

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 523689182  164 QRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQReyGLSVIFVTHDIGVAAEvADRIAVM 231
Cdd:TIGR02857 465 QRLALARAFLRDAPLLLLDEPTAHLDAETEAEVLEALRALAQ--GRTVLLVTHRLALAAL-ADRIVVL 529

tauB

PRK11248

taurine ABC transporter ATP-binding subunit;

8-238

5.10e-22

taurine ABC transporter ATP-binding subunit;

Pssm-ID: 183056 [Multi-domain] Cd Length: 255 Bit Score: 92.84 E-value: 5.10e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSVTFrrGGKavKAVNGVSLSVKPGEVVALLGESGSGKSvtmrSLLrlhpkgTLIEGGMTVDGHDImSLSNRAL 87
Cdd:PRK11248   1 MLQISHLYADY--GGK--PALEDINLTLESGELLVVLGPSGCGKT----TLL------NLIAGFVPYQHGSI-TLDGKPV 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  88 SDlRGAVVSMVFQEPRL-----ALDPVyTVGRQIEetimrheKVSRGLAAERALALFQKVRIPSPERRlsnYPHEMSGGM 162
Cdd:PRK11248  66 EG-PGAERGVVFQNEGLlpwrnVQDNV-AFGLQLA-------GVEKMQRLEIAHQMLKKVGLEGAEKR---YIWQLSGGQ 133

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 163 LQRAMIAMALACNPKVLLADEPTTALDATV--QIQILLLirELQREYGLSVIFVTHDIGVAAEVADRIAVMY--AGRIVE 238
Cdd:PRK11248 134 RQRVGIARALAANPQLLLLDEPFGALDAFTreQMQTLLL--KLWQETGKQVLLITHDIEEAVFMATELVLLSpgPGRVVE 211

ntrCD

TIGR01184

nitrate transport ATP-binding subunits C and D; This model describes the ATP binding subunits ...

28-251

5.41e-22

nitrate transport ATP-binding subunits C and D; This model describes the ATP binding subunits of nitrate transport in bacteria and archaea. This protein belongs to the ATP-binding cassette (ABC) superfamily. It is thought that the two subunits encoded by ntrC and ntrD form the binding surface for interaction with ATP. This model is restricted in identifying ATP binding subunit associated with the nitrate transport. Nitrate assimilation is aided by other proteins derived from the operon which among others include products of ntrA - a regulatory protein; ntrB - a hydropbobic transmembrane permease and narB - a reductase. [Transport and binding proteins, Anions, Transport and binding proteins, Other]

Pssm-ID: 130252 [Multi-domain] Cd Length: 230 Bit Score: 92.53 E-value: 5.41e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   28 VNGVSLSVKPGEVVALLGESGSGKS--VTMRSLLRLHPKGTLIEGGMTVD--GHDIMSL-SNRALSDLRgavvsMVFQEP 102
Cdd:TIGR01184   1 LKGVNLTIQQGEFISLIGHSGCGKStlLNLISGLAQPTSGGVILEGKQITepGPDRMVVfQNYSLLPWL-----TVRENI 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  103 RLALDPVYTVGRQIE-ETIMRH--EKVSRGLAAERalalfqkvripsperrlsnYPHEMSGGMLQRAMIAMALACNPKVL 179
Cdd:TIGR01184  76 ALAVDRVLPDLSKSErRAIVEEhiALVGLTEAADK-------------------RPGQLSGGMKQRVAIARALSIRPKVL 136

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 523689182  180 LADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDI-IRNPRH 251
Cdd:TIGR01184 137 LLDEPFGALDALTRGNLQEELMQIWEEHRVTVLMVTHDVDEALLLSDRVVMLTNGPAANIGQILEVpFPRPRD 209

ABCC_TAP

cd03248

ATP-binding cassette domain of the Transporter Associated with Antigen Processing, subfamily C; ...

6-236

5.66e-22

ATP-binding cassette domain of the Transporter Associated with Antigen Processing, subfamily C; TAP (Transporter Associated with Antigen Processing) is essential for peptide delivery from the cytosol into the lumen of the endoplasmic reticulum (ER), where these peptides are loaded on major histocompatibility complex (MHC) I molecules. Loaded MHC I leave the ER and display their antigenic cargo on the cell surface to cytotoxic T cells. Subsequently, virus-infected or malignantly transformed cells can be eliminated. TAP belongs to the large family of ATP-binding cassette (ABC) transporters, which translocate a vast variety of solutes across membranes.

Pssm-ID: 213215 [Multi-domain] Cd Length: 226 Bit Score: 92.15 E-value: 5.66e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   6 DAMIDISNLSVTFRRGgKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPkgtLIEGGMTVDGHDIMSLSNR 85
Cdd:cd03248    9 KGIVKFQNVTFAYPTR-PDTLVLQDVSFTLHPGEVTALVGPSGSGKSTVVALLENFYQ---PQGGQVLLDGKPISQYEHK 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  86 ALSdlrgAVVSMVFQEPRLaldpvytVGRQIEETImrhekvSRGLAA---ERALALFQKVRIPSPERRLSNYPHE----- 157
Cdd:cd03248   85 YLH----SKVSLVGQEPVL-------FARSLQDNI------AYGLQScsfECVKEAAQKAHAHSFISELASGYDTevgek 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 158 ---MSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIfvTHDIGVaAEVADRIAVMYAG 234
Cdd:cd03248  148 gsqLSGGQKQRVAIARALIRNPQVLILDEATSALDAESEQQVQQALYDWPERRTVLVI--AHRLST-VERADQILVLDGG 224


                 ..
gi 523689182 235 RI 236
Cdd:cd03248  225 RI 226

PRK13651

cobalt transporter ATP-binding subunit; Provisional

3-248

6.28e-22

cobalt transporter ATP-binding subunit; Provisional

Pssm-ID: 184210 [Multi-domain] Cd Length: 305 Bit Score: 93.61 E-value: 6.28e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   3 MQndamIDISNLSVTFRRGGK-AVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSL--LRLHPKGTLIEggMTVDGHDi 79
Cdd:PRK13651   1 MQ----IKVKNIVKIFNKKLPtELKALDNVSVEINQGEFIAIIGQTGSGKTTFIEHLnaLLLPDTGTIEW--IFKDEKN- 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  80 mslsNRALSDLRGAVVSMVFQEPRL-ALDPVYTVGRQI------------EETImrhEK----------VSRGLAAERAL 136
Cdd:PRK13651  74 ----KKKTKEKEKVLEKLVIQKTRFkKIKKIKEIRRRVgvvfqfaeyqlfEQTI---EKdiifgpvsmgVSKEEAKKRAA 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 137 ALFQKVRIPspERRLSNYPHEMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTH 216
Cdd:PRK13651 147 KYIELVGLD--ESYLQRSPFELSGGQKRRVALAGILAMEPDFLVFDEPTAGLDPQGVKEILEIFDNLNKQ-GKTIILVTH 223

                        250       260       270
                 ....*....|....*....|....*....|..
gi 523689182 217 DIGVAAEVADRIAVMYAGRIVEEGLVGDIIRN 248
Cdd:PRK13651 224 DLDNVLEWTKRTIFFKDGKIIKDGDTYDILSD 255

ABCC_cytochrome_bd

cd03247

ATP-binding cassette domain of CydCD, subfamily C; The CYD subfamily implicated in cytochrome ...

9-240

6.90e-22

ATP-binding cassette domain of CydCD, subfamily C; The CYD subfamily implicated in cytochrome bd biogenesis. The CydC and CydD proteins are important for the formation of cytochrome bd terminal oxidase of E. coli and it has been proposed that they were necessary for biosynthesis of the cytochrome bd quinol oxidase and for periplasmic c-type cytochromes. CydCD were proposed to determine a heterooligomeric complex important for heme export into the periplasm or to be involved in the maintenance of the proper redox state of the periplasmic space. In Bacillus subtilis, the absence of CydCD does not affect the presence of halo-cytochrome c in the membrane and this observation suggests that CydCD proteins are not involved in the export of heme in this organism.

Pssm-ID: 213214 [Multi-domain] Cd Length: 178 Bit Score: 90.84 E-value: 6.90e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTFrrGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSvTMRSLLR--LHPKgtliEGGMTVDGHDIMSLSNrA 86
Cdd:cd03247    1 LSINNVSFSY--PEQEQQVLKNLSLELKQGEKIALLGRSGSGKS-TLLQLLTgdLKPQ----QGEITLDGVPVSDLEK-A 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  87 LSDLrgavVSMVFQEPRLaldpvytvgrqIEETIMrhekvsrglaaeralalfqkvripsperrlSNYPHEMSGGMLQRA 166
Cdd:cd03247   73 LSSL----ISVLNQRPYL-----------FDTTLR------------------------------NNLGRRFSGGERQRL 107

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 523689182 167 MIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYglSVIFVTHDIgVAAEVADRIAVMYAGRIVEEG 240
Cdd:cd03247  108 ALARILLQDAPIVLLDEPTVGLDPITERQLLSLIFEVLKDK--TLIWITHHL-TGIEHMDKILFLENGKIIMQG 178

cbiO

PRK13645

energy-coupling factor transporter ATPase;

1-248

7.99e-22

energy-coupling factor transporter ATPase;

Pssm-ID: 184204 [Multi-domain] Cd Length: 289 Bit Score: 93.15 E-value: 7.99e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   1 MTMQNDAMIDisNLSVTF-RRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSvTMRSLlrlhPKGTLI-EGGMTVDGhD 78
Cdd:PRK13645   1 FDFSKDIILD--NVSYTYaKKTPFEFKALNNTSLTFKKNKVTCVIGTTGSGKS-TMIQL----TNGLIIsETGQTIVG-D 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  79 IMSLSN----RALSDLRGAVvSMVFQEPRLALdpvytvgrqIEETIMR-------HEKVSRGLAAERALALFQKVRIPsp 147
Cdd:PRK13645  73 YAIPANlkkiKEVKRLRKEI-GLVFQFPEYQL---------FQETIEKdiafgpvNLGENKQEAYKKVPELLKLVQLP-- 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 148 ERRLSNYPHEMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADR 227
Cdd:PRK13645 141 EDYVKRSPFELSGGQKRRVALAGIIAMDGNTLVLDEPTGGLDPKGEEDFINLFERLNKEYKKRIIMVTHNMDQVLRIADE 220

                        250       260
                 ....*....|....*....|.
gi 523689182 228 IAVMYAGRIVEEGLVGDIIRN 248
Cdd:PRK13645 221 VIVMHEGKVISIGSPFEIFSN 241

cbiO

PRK13644

energy-coupling factor transporter ATPase;

8-266

8.04e-22

energy-coupling factor transporter ATPase;

Pssm-ID: 106587 [Multi-domain] Cd Length: 274 Bit Score: 92.74 E-value: 8.04e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSVTFRRGGKAVKAVNgvsLSVKPGEVVALLGESGSGKSVtmrslLRLHPKGTL--IEGGMTVDGHDIMSLSNr 85
Cdd:PRK13644   1 MIRLENVSYSYPDGTPALENIN---LVIKKGEYIGIIGKNGSGKST-----LALHLNGLLrpQKGKVLVSGIDTGDFSK- 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  86 aLSDLRgAVVSMVFQEPRLALdpvytVGRQIEET------------IMRHEKVSRGLAaERALalfQKVRIPSPErrlsn 153
Cdd:PRK13644  72 -LQGIR-KLVGIVFQNPETQF-----VGRTVEEDlafgpenlclppIEIRKRVDRALA-EIGL---EKYRHRSPK----- 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 154 yphEMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGvAAEVADRIAVMYA 233
Cdd:PRK13644 136 ---TLSGGQGQCVALAGILTMEPECLIFDEVTSMLDPDSGIAVLERIKKLHEK-GKTIVYITHNLE-ELHDADRIIVMDR 210

                        250       260       270
                 ....*....|....*....|....*....|...
gi 523689182 234 GRIVEEGLVGDIIRNPRHPYTKGLLGARVELAE 266
Cdd:PRK13644 211 GKIVLEGEPENVLSDVSLQTLGLTPPSLIELAE 243

ABC_NatA_like

cd03267

ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; ...

18-240

1.10e-21

ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; NatA is the ATPase component of a bacterial ABC-type Na+ transport system called NatAB, which catalyzes ATP-dependent electrogenic Na+ extrusion without mechanically coupled to proton or K+ uptake. NatB possess six putative membrane spanning regions at its C-terminus. In B. subtilis, NatAB is inducible by agents such as ethanol and protonophores, which lower the proton-motive force across the membrane. The closest sequence similarity to NatA is exhibited by DrrA of the two-component daunorubicin- and doxorubicin-efflux system. Hence, the functional NatAB is presumably assembled with two copies of the single ATP-binding protein and the single integral membrane protein.

Pssm-ID: 213234 [Multi-domain] Cd Length: 236 Bit Score: 91.63 E-value: 1.10e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  18 FRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLR-LHPKgtliEGGMTVDGHDIMSLSNRALSDLrgavvS 96
Cdd:cd03267   27 FKRKYREVEALKGISFTIEKGEIVGFIGPNGAGKTTTLKILSGlLQPT----SGEVRVAGLVPWKRRKKFLRRI-----G 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  97 MVF-QEPRLALD-PV---YTVGRQI-----EETIMRHEKVSRGLAAERALAlfqkvripSPERRLSNyphemsgGMLQRA 166
Cdd:cd03267   98 VVFgQKTQLWWDlPVidsFYLLAAIydlppARFKKRLDELSELLDLEELLD--------TPVRQLSL-------GQRMRA 162

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 523689182 167 MIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEG 240
Cdd:cd03267  163 EIAAALLHEPEILFLDEPTIGLDVVAQENIRNFLKEYNRERGTTVLLTSHYMKDIEALARRVLVIDKGRLLYDG 236

GguA

NF040905

sugar ABC transporter ATP-binding protein;

25-238

1.17e-21

sugar ABC transporter ATP-binding protein;

Pssm-ID: 468840 [Multi-domain] Cd Length: 500 Bit Score: 95.24 E-value: 1.17e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  25 VKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGTLiEGGMTVDGhDIMSLSNRALSDLRGAVVsmVFQEprL 104
Cdd:NF040905  14 VKALDDVNLSVREGEIHALCGENGAGKSTLMKVLSGVYPHGSY-EGEILFDG-EVCRFKDIRDSEALGIVI--IHQE--L 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 105 ALDPVYTvgrqIEETI-MRHEKVSRGL-----AAERALALFQKVRIP-SPERRLSNypheMSGGMLQRAMIAMALACNPK 177
Cdd:NF040905  88 ALIPYLS----IAENIfLGNERAKRGVidwneTNRRARELLAKVGLDeSPDTLVTD----IGVGKQQLVEIAKALSKDVK 159

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 523689182 178 VLLADEPTTALDATVQIQILLLIRELqREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVE 238
Cdd:NF040905 160 LLILDEPTAALNEEDSAALLDLLLEL-KAQGITSIIISHKLNEIRRVADSITVLRDGRTIE 219

LptB

COG1137

ABC-type lipopolysaccharide export system, ATPase component [Cell wall/membrane/envelope ...

7-250

1.76e-21

ABC-type lipopolysaccharide export system, ATPase component [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 440752 [Multi-domain] Cd Length: 240 Bit Score: 91.24 E-value: 1.76e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   7 AMIDISNLSVTFrrGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLrlhpkGtLI---EGGMTVDGHDI--MS 81
Cdd:COG1137    2 MTLEAENLVKSY--GKRTV--VKDVSLEVNQGEIVGLLGPNGAGKTTTFYMIV-----G-LVkpdSGRIFLDGEDIthLP 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  82 LSNRAlsdLRGavVSMVFQEP----RLaldpvyTVgrqiEETIM---RHEKVSRGLAAERALALFQKVRIpspERRLSNY 154
Cdd:COG1137   72 MHKRA---RLG--IGYLPQEAsifrKL------TV----EDNILavlELRKLSKKEREERLEELLEEFGI---THLRKSK 133

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 155 PHEMSGGMLQRAMIAMALACNPKVLLADEPTTALD--ATVQIQilLLIRELqREYGLSVIFVTHDIGVAAEVADRIAVMY 232
Cdd:COG1137  134 AYSLSGGERRRVEIARALATNPKFILLDEPFAGVDpiAVADIQ--KIIRHL-KERGIGVLITDHNVRETLGICDRAYIIS 210

                        250
                 ....*....|....*...
gi 523689182 233 AGRIVEEGLVGDIIRNPR 250
Cdd:COG1137  211 EGKVLAEGTPEEILNNPL 228

ABC_ThiQ_thiamine_transporter

cd03298

ATP-binding cassette domain of the thiamine transport system; Part of the ...

32-240

1.91e-21

ATP-binding cassette domain of the thiamine transport system; Part of the binding-protein-dependent transport system tbpA-thiPQ for thiamine and TPP. Probably responsible for the translocation of thiamine across the membrane. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213265 [Multi-domain] Cd Length: 211 Bit Score: 90.24 E-value: 1.91e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  32 SLSVKPGEVVALLGESGSGKSvtmrSLLRLHPK-GTLIEGGMTVDGHDI--MSLSNRAlsdlrgavVSMVFQEPRLAldP 108
Cdd:cd03298   18 DLTFAQGEITAIVGPSGSGKS----TLLNLIAGfETPQSGRVLINGVDVtaAPPADRP--------VSMLFQENNLF--A 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 109 VYTVGRQIEETI---MRHEKVSRGlAAERALAlfqKVRIPSPERRLsnyPHEMSGGMLQRAMIAMALACNPKVLLADEPT 185
Cdd:cd03298   84 HLTVEQNVGLGLspgLKLTAEDRQ-AIEVALA---RVGLAGLEKRL---PGELSGGERQRVALARVLVRDKPVLLLDEPF 156

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 523689182 186 TALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEG 240
Cdd:cd03298  157 AALDPALRAEMLDLVLDLHAETKMTVLMVTHQPEDAKRLAQRVVFLDNGRIAAQG 211

ABC_YhbG

cd03218

ATP-binding cassette component of YhbG transport system; The ABC transporters belonging to the ...

9-249

2.05e-21

ATP-binding cassette component of YhbG transport system; The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in cell envelope during biogenesis. YhbG is the putative ATP-binding cassette component and YhbN is the putative periplasmic-binding protein. Depletion of each gene product leads to growth arrest, irreversible cell damage and loss of viability in E. coli. The YhbG homolog (NtrA) is essential in Rhizobium meliloti, a symbiotic nitrogen-fixing bacterium.

Pssm-ID: 213185 [Multi-domain] Cd Length: 232 Bit Score: 90.68 E-value: 2.05e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTFRRGgkavKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGtliEGGMTVDGHDI--MSLSNRA 86
Cdd:cd03218    1 LRAENLSKRYGKR----KVVNGVSLSVKQGEIVGLLGPNGAGKTTTFYMIVGLVKPD---SGKILLDGQDItkLPMHKRA 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  87 lsdLRGavVSMVFQEPrlaldpvyTVGRQ--IEETIM---RHEKVSRGLAAERALALFQKVRIPSPERRLSNYpheMSGG 161
Cdd:cd03218   74 ---RLG--IGYLPQEA--------SIFRKltVEENILavlEIRGLSKKEREEKLEELLEEFHITHLRKSKASS---LSGG 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 162 MLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELqREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGL 241
Cdd:cd03218  138 ERRRVEIARALATNPKFLLLDEPFAGVDPIAVQDIQKIIKIL-KDRGIGVLITDHNVRETLSITDRAYIIYEGKVLAEGT 216


                 ....*...
gi 523689182 242 VGDIIRNP 249
Cdd:cd03218  217 PEEIAANE 224

oligo_HPY

pfam08352

Oligopeptide/dipeptide transporter, C-terminal region; This family features a region found ...

237-301

2.29e-21

Oligopeptide/dipeptide transporter, C-terminal region; This family features a region found towards the C-terminus of oligopeptide ABC transporter ATP binding proteins, immediately following the ATP-binding domain (pfam00005). All characterized members appear able to be involved in the transport of oligopeptides or dipeptides. Some are important for sporulation or antibiotic resistance. Some dipeptide transporters also act on the heme precursor delta-aminolevulinic acid.

Pssm-ID: 400588 [Multi-domain] Cd Length: 65 Bit Score: 85.92 E-value: 2.29e-21

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 523689182  237 VEEGLVGDIIRNPRHPYTKGLLGARVELAEGRDRLVTIPGAPPDLAAMPPGCAFAPRCVQVSDLC 301
Cdd:pfam08352   1 VEEGPTDDILENPLHPYTRALLNSVPRLDPPKRPLYTIPGNVPSLLELPEGCPFAPRCPFATEEC 65

thiQ

PRK10771

thiamine ABC transporter ATP-binding protein ThiQ;

32-240

2.59e-21

thiamine ABC transporter ATP-binding protein ThiQ;

Pssm-ID: 182716 [Multi-domain] Cd Length: 232 Bit Score: 90.41 E-value: 2.59e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  32 SLSVKPGEVVALLGESGSGKSvTMRSLLR--LHPKGtlieGGMTVDG--HDIMSLSNRAlsdlrgavVSMVFQEPRLAld 107
Cdd:PRK10771  19 DLTVERGERVAILGPSGAGKS-TLLNLIAgfLTPAS----GSLTLNGqdHTTTPPSRRP--------VSMLFQENNLF-- 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 108 PVYTVGRQIEETIMRHEKVSrglAAERAL--ALFQKVRIpspERRLSNYPHEMSGGMLQRAMIAMALACNPKVLLADEPT 185
Cdd:PRK10771  84 SHLTVAQNIGLGLNPGLKLN---AAQREKlhAIARQMGI---EDLLARLPGQLSGGQRQRVALARCLVREQPILLLDEPF 157

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 523689182 186 TALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEG 240
Cdd:PRK10771 158 SALDPALRQEMLTLVSQVCQERQLTLLMVSHSLEDAARIAPRSLVVADGRIAWDG 212

cbiO

PRK13648

cobalt transporter ATP-binding subunit; Provisional

3-245

8.98e-21

cobalt transporter ATP-binding subunit; Provisional

Pssm-ID: 184207 [Multi-domain] Cd Length: 269 Bit Score: 89.81 E-value: 8.98e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   3 MQNDAMIDISNlsVTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRsllrlhpkgtLIEGGMTV-DGHDIMS 81
Cdd:PRK13648   2 EDKNSIIVFKN--VSFQYQSDASFTLKDVSFNIPKGQWTSIVGHNGSGKSTIAK----------LMIGIEKVkSGEIFYN 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  82 ---LSNRALSDLRGAVvSMVFQEPR-------LALDPVYTVGRQIEETIMRHEKVSRGLAAERALAlfqkvripsperRL 151
Cdd:PRK13648  70 nqaITDDNFEKLRKHI-GIVFQNPDnqfvgsiVKYDVAFGLENHAVPYDEMHRRVSEALKQVDMLE------------RA 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 152 SNYPHEMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEvADRIAVM 231
Cdd:PRK13648 137 DYEPNALSGGQKQRVAIAGVLALNPSVIILDEATSMLDPDARQNLLDLVRKVKSEHNITIISITHDLSEAME-ADHVIVM 215

                        250
                 ....*....|....
gi 523689182 232 YAGRIVEEGLVGDI 245
Cdd:PRK13648 216 NKGTVYKEGTPTEI 229

PRK11176

lipid A ABC transporter ATP-binding protein/permease MsbA;

10-240

1.19e-20

lipid A ABC transporter ATP-binding protein/permease MsbA;

Pssm-ID: 183016 [Multi-domain] Cd Length: 582 Bit Score: 92.39 E-value: 1.19e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  10 DISNLSVTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSvTMRSLL-RLHpkgTLIEGGMTVDGHDIMSLSnraLS 88
Cdd:PRK11176 341 DIEFRNVTFTYPGKEVPALRNINFKIPAGKTVALVGRSGSGKS-TIANLLtRFY---DIDEGEILLDGHDLRDYT---LA 413

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  89 DLRGAvVSMVFQEPRLALDpvyTVGRQIeeTIMRHEKVSRG---LAAERALAL-FqkvrIPSPERRLSNYPHE----MSG 160
Cdd:PRK11176 414 SLRNQ-VALVSQNVHLFND---TIANNI--AYARTEQYSREqieEAARMAYAMdF----INKMDNGLDTVIGEngvlLSG 483

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 161 GMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYglSVIFVTHDIGvAAEVADRIAVMYAGRIVEEG 240
Cdd:PRK11176 484 GQRQRIAIARALLRDSPILILDEATSALDTESERAIQAALDELQKNR--TSLVIAHRLS-TIEKADEILVVEDGEIVERG 560

met_CoM_red_A2

TIGR03269

methyl coenzyme M reductase system, component A2; The enzyme that catalyzes the final step in ...

8-247

1.61e-20

methyl coenzyme M reductase system, component A2; The enzyme that catalyzes the final step in methanogenesis, methyl coenzyme M reductase, contains alpha, beta, and gamma chains. In older literature, the complex of alpha, beta, and gamma chains was termed component C, while this single chain protein was termed methyl coenzyme M reductase system component A2. [Energy metabolism, Methanogenesis]

Pssm-ID: 132313 [Multi-domain] Cd Length: 520 Bit Score: 91.79 E-value: 1.61e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182    8 MIDISNLSVTFRRGgkAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGtliEGGMTVD-GHDIMSLSNRA 86
Cdd:TIGR03269 282 VRNVSKRYISVDRG--VVKAVDNVSLEVKEGEIFGIVGTSGAGKTTLSKIIAGVLEPT---SGEVNVRvGDEWVDMTKPG 356

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   87 LsDLRGAV---VSMVFQEprLALDPVYTVGRQIEETIMRheKVSRGLAAERALALFQKVRIPSPERR--LSNYPHEMSGG 161
Cdd:TIGR03269 357 P-DGRGRAkryIGILHQE--YDLYPHRTVLDNLTEAIGL--ELPDELARMKAVITLKMVGFDEEKAEeiLDKYPDELSEG 431

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  162 MLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGL 241
Cdd:TIGR03269 432 ERHRVALAQVLIKEPRIVILDEPTGTMDPITKVDVTHSILKAREEMEQTFIIVSHDMDFVLDVCDRAALMRDGKIVKIGD 511


                  ....*.
gi 523689182  242 VGDIIR 247
Cdd:TIGR03269 512 PEEIVE 517

PRK11000

maltose/maltodextrin ABC transporter ATP-binding protein MalK;

15-260

1.85e-20

maltose/maltodextrin ABC transporter ATP-binding protein MalK;

Pssm-ID: 182893 [Multi-domain] Cd Length: 369 Bit Score: 90.47 E-value: 1.85e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  15 SVTFRRGGKA---VKAVNGVSLSVKPGEVVALLGESGSGKSvtmrSLLRLhpkgtlIEGGMTVDGHDIMsLSNRALSDL- 90
Cdd:PRK11000   3 SVTLRNVTKAygdVVISKDINLDIHEGEFVVFVGPSGCGKS----TLLRM------IAGLEDITSGDLF-IGEKRMNDVp 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  91 ---RGavVSMVFQEprLALDPVYTVGrqieetimrhEKVSRGLA------AERALALFQKVRIPSPERRLSNYPHEMSGG 161
Cdd:PRK11000  72 paeRG--VGMVFQS--YALYPHLSVA----------ENMSFGLKlagakkEEINQRVNQVAEVLQLAHLLDRKPKALSGG 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 162 MLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGL 241
Cdd:PRK11000 138 QRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGK 217

                        250
                 ....*....|....*....
gi 523689182 242 VGDIIRNPRHPYTKGLLGA 260
Cdd:PRK11000 218 PLELYHYPANRFVAGFIGS 236

ABC_FeS_Assembly

cd03217

ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Biosynthesis of ...

11-248

2.07e-20

ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Biosynthesis of iron-sulfur clusters (Fe-S) depends on multi-protein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under stressful conditions. The SUF system is made of six proteins: SufC is an atypical cytoplasmic ABC-ATPase, which forms a complex with SufB and SufD; SufA plays the role of a scaffold protein for assembly of iron-sulfur clusters and delivery to target proteins; SufS is a cysteine desulfurase which mobilizes the sulfur atom from cysteine and provides it to the cluster; SufE has no associated function yet.

Pssm-ID: 213184 [Multi-domain] Cd Length: 200 Bit Score: 87.20 E-value: 2.07e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  11 ISNLSVtfRRGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSvTMRSLLRLHPKGTLIEGGMTVDGHDI--MSLSNRAls 88
Cdd:cd03217    3 IKDLHV--SVGGKEI--LKGVNLTIKKGEVHALMGPNGSGKS-TLAKTIMGHPKYEVTEGEILFKGEDItdLPPEERA-- 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  89 dLRGavVSMVFQEPrlaldpvytvgrqieetimrhekvsrglaaeralalfqkVRIpsPERRLSNYPHEM----SGGMLQ 164
Cdd:cd03217   76 -RLG--IFLAFQYP---------------------------------------PEI--PGVKNADFLRYVnegfSGGEKK 111

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 165 RAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELqREYGLSVIFVTHDIGVAAEV-ADRIAVMYAGRIVEEG--- 240
Cdd:cd03217  112 RNEILQLLLLEPDLAILDEPDSGLDIDALRLVAEVINKL-REEGKSVLIITHYQRLLDYIkPDRVHVLYDGRIVKSGdke 190


                 ....*...
gi 523689182 241 LVGDIIRN 248
Cdd:cd03217  191 LALEIEKK 198

thiQ

TIGR01277

thiamine ABC transporter, ATP-binding protein; This model describes the energy-transducing ...

32-236

2.51e-20

thiamine ABC transporter, ATP-binding protein; This model describes the energy-transducing ATPase subunit ThiQ of the ThiBPQ thiamine (and thiamine pyrophosphate) ABC transporter in several Proteobacteria. This protein is found so far only in Proteobacteria, and is found in complete genomes only if the ThiB and ThiP subunits are also found. [Transport and binding proteins, Other]

Pssm-ID: 130344 [Multi-domain] Cd Length: 213 Bit Score: 87.22 E-value: 2.51e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   32 SLSVKPGEVVALLGESGSGKSvTMRSLLR--LHPkgtlIEGGMTVDGHDIMSL--SNRAlsdlrgavVSMVFQEPRLAld 107
Cdd:TIGR01277  18 DLNVADGEIVAIMGPSGAGKS-TLLNLIAgfIEP----ASGSIKVNDQSHTGLapYQRP--------VSMLFQENNLF-- 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  108 PVYTVGRQIEETIMRHEKVSrGLAAERALALFQKVRIPSPERRLsnyPHEMSGGMLQRAMIAMALACNPKVLLADEPTTA 187
Cdd:TIGR01277  83 AHLTVRQNIGLGLHPGLKLN-AEQQEKVVDAAQQVGIADYLDRL---PEQLSGGQRQRVALARCLVRPNPILLLDEPFSA 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 523689182  188 LDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRI 236
Cdd:TIGR01277 159 LDPLLREEMLALVKQLCSERQRTLLMVTHHLSDARAIASQIAVVSQGKI 207

PRK10253

iron-enterobactin ABC transporter ATP-binding protein;

22-246

2.71e-20

iron-enterobactin ABC transporter ATP-binding protein;

Pssm-ID: 182336 [Multi-domain] Cd Length: 265 Bit Score: 88.50 E-value: 2.71e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  22 GKAVKAVNgVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHpkgTLIEGGMTVDGHDIMSLSNRALSDLRGAV------- 94
Cdd:PRK10253  18 GKYTVAEN-LTVEIPDGHFTAIIGPNGCGKSTLLRTLSRLM---TPAHGHVWLDGEHIQHYASKEVARRIGLLaqnattp 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  95 ----VSMVFQEPRLALDPVYTVGRQIEEtimrhEKVSRGLAAERALAL-FQKVripsperrlsnypHEMSGGMLQRAMIA 169
Cdd:PRK10253  94 gditVQELVARGRYPHQPLFTRWRKEDE-----EAVTKAMQATGITHLaDQSV-------------DTLSGGQRQRAWIA 155

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 523689182 170 MALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDII 246
Cdd:PRK10253 156 MVLAQETAIMLLDEPTTWLDISHQIDLLELLSELNREKGYTLAAVLHDLNQACRYASHLIALREGKIVAQGAPKEIV 232

livG

PRK11300

leucine/isoleucine/valine transporter ATP-binding subunit; Provisional

8-250

3.67e-20

leucine/isoleucine/valine transporter ATP-binding subunit; Provisional

Pssm-ID: 183080 [Multi-domain] Cd Length: 255 Bit Score: 87.74 E-value: 3.67e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSVTFrrGGkaVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLH-PKGtlieGGMTVDGHDIMSLSNRA 86
Cdd:PRK11300   5 LLSVSGLMMRF--GG--LLAVNNVNLEVREQEIVSLIGPNGAGKTTVFNCLTGFYkPTG----GTILLRGQHIEGLPGHQ 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  87 LSdlRGAVVSmVFQEPRLALDpvYTVgrqIEE-TIMRHEKVSRGL----------------AAERALALFQKVRIpspeR 149
Cdd:PRK11300  77 IA--RMGVVR-TFQHVRLFRE--MTV---IENlLVAQHQQLKTGLfsgllktpafrraeseALDRAATWLERVGL----L 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 150 RLSNYPH-EMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRI 228
Cdd:PRK11300 145 EHANRQAgNLAYGQQRRLEIARCMVTQPEILMLDEPAAGLNPKETKELDELIAELRNEHNVTVLLIEHDMKLVMGISDRI 224

                        250       260
                 ....*....|....*....|..
gi 523689182 229 AVMYAGRIVEEGLVGDIIRNPR 250
Cdd:PRK11300 225 YVVNQGTPLANGTPEEIRNNPD 246

PRK09700

D-allose ABC transporter ATP-binding protein AlsA;

8-245

4.10e-20

D-allose ABC transporter ATP-binding protein AlsA;

Pssm-ID: 182036 [Multi-domain] Cd Length: 510 Bit Score: 90.61 E-value: 4.10e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSVTFrrGGkaVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGTlieGGMTVDGHDIMSLSNRAL 87
Cdd:PRK09700   5 YISMAGIGKSF--GP--VHALKSVNLTVYPGEIHALLGENGAGKSTLMKVLSGIHEPTK---GTITINNINYNKLDHKLA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  88 SDLRgavVSMVFQEPRL-----ALDPVYtVGRQIEETIMRHEKVSRGLAAERALALFQKVRIpspERRLSNYPHEMSGGM 162
Cdd:PRK09700  78 AQLG---IGIIYQELSVideltVLENLY-IGRHLTKKVCGVNIIDWREMRVRAAMMLLRVGL---KVDLDEKVANLSISH 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 163 LQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLV 242
Cdd:PRK09700 151 KQMLEIAKTLMLDAKVIIMDEPTSSLTNKEVDYLFLIMNQLRKE-GTAIVYISHKLAEIRRICDRYTVMKDGSSVCSGMV 229


                 ...
gi 523689182 243 GDI 245
Cdd:PRK09700 230 SDV 232

YnjD

COG4136

ABC-type uncharacterized transport system YnjBCD, ATPase component [General function ...

8-228

5.91e-20

ABC-type uncharacterized transport system YnjBCD, ATPase component [General function prediction only];

Pssm-ID: 443311 [Multi-domain] Cd Length: 211 Bit Score: 86.38 E-value: 5.91e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSVTfrRGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSvtmrSLLrLHPKGTL-----IEGGMTVDGHDIMSL 82
Cdd:COG4136    1 MLSLENLTIT--LGGRPL--LAPLSLTVAPGEILTLMGPSGSGKS----TLL-AAIAGTLspafsASGEVLLNGRRLTAL 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  83 SNRAlsdlRGavVSMVFQEPrlALDPVYTVGRQI----EETIMRHEkvsRGLAAERALAlfqKVRIPSPERRlsnYPHEM 158
Cdd:COG4136   72 PAEQ----RR--IGILFQDD--LLFPHLSVGENLafalPPTIGRAQ---RRARVEQALE---EAGLAGFADR---DPATL 134

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 523689182 159 SGGmlQRAMIAM--ALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGvAAEVADRI 228
Cdd:COG4136  135 SGG--QRARVALlrALLAEPRALLLDEPFSKLDAALRAQFREFVFEQIRQRGIPALLVTHDEE-DAPAAGRV 203

cbiO

PRK13643

energy-coupling factor transporter ATPase;

8-247

6.94e-20

energy-coupling factor transporter ATPase;

Pssm-ID: 184203 [Multi-domain] Cd Length: 288 Bit Score: 87.87 E-value: 6.94e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSVTFRRGGK-AVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRsllrlHPKGTLIEGGMTVDGHDIMSLSNRA 86
Cdd:PRK13643   1 MIKFEKVNYTYQPNSPfASRALFDIDLEVKKGSYTALIGHTGSGKSTLLQ-----HLNGLLQPTEGKVTVGDIVVSSTSK 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  87 LSDLRGA--VVSMVFQEPRLALdpvytvgrqIEETIMRHEKV---SRGLAAERALALF-QKVRIPSPERRL-SNYPHEMS 159
Cdd:PRK13643  76 QKEIKPVrkKVGVVFQFPESQL---------FEETVLKDVAFgpqNFGIPKEKAEKIAaEKLEMVGLADEFwEKSPFELS 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 160 GGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQrEYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEE 239
Cdd:PRK13643 147 GGQMRRVAIAGILAMEPEVLVLDEPTAGLDPKARIEMMQLFESIH-QSGQTVVLVTHLMDDVADYADYVYLLEKGHIISC 225


                 ....*...
gi 523689182 240 GLVGDIIR 247
Cdd:PRK13643 226 GTPSDVFQ 233

PRK10895

lipopolysaccharide ABC transporter ATP-binding protein; Provisional

23-248

1.13e-19

lipopolysaccharide ABC transporter ATP-binding protein; Provisional

Pssm-ID: 182817 [Multi-domain] Cd Length: 241 Bit Score: 86.10 E-value: 1.13e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  23 KAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGTlieGGMTVDGHDI--MSLSNRALsdlRGavVSMVFQ 100
Cdd:PRK10895  14 KGRRVVEDVSLTVNSGEIVGLLGPNGAGKTTTFYMVVGIVPRDA---GNIIIDDEDIslLPLHARAR---RG--IGYLPQ 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 101 EP----RLALDPVYTVGRQIEETIMRHEKvsrglaAERALALFQKVRIpspERRLSNYPHEMSGGMLQRAMIAMALACNP 176
Cdd:PRK10895  86 EAsifrRLSVYDNLMAVLQIRDDLSAEQR------EDRANELMEEFHI---EHLRDSMGQSLSGGERRRVEIARALAANP 156

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 523689182 177 KVLLADEPTTALDATVQIQILLLIRELqREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDIIRN 248
Cdd:PRK10895 157 KFILLDEPFAGVDPISVIDIKRIIEHL-RDSGLGVLITDHNVRETLAVCERAYIVSQGHLIAHGTPTEILQD 227

ABCG_PDR_domain1

cd03233

First domain of the pleiotropic drug resistance-like subfamily G of ATP-binding cassette ...

13-237

2.81e-19

First domain of the pleiotropic drug resistance-like subfamily G of ATP-binding cassette transporters; The pleiotropic drug resistance (PDR) is a well-described phenomenon occurring in fungi and shares several similarities with processes in bacteria and higher eukaryotes. This PDR subfamily represents domain I of its (ABC-IM)2 organization. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213200 [Multi-domain] Cd Length: 202 Bit Score: 84.24 E-value: 2.81e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  13 NLSVTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGTLIEGGMTVDGHDIMSLSNRALSDlrg 92
Cdd:cd03233    8 NISFTTGKGRSKIPILKDFSGVVKPGEMVLVLGRPGSGCSTLLKALANRTEGNVSVEGDIHYNGIPYKEFAEKYPGE--- 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  93 avVSMVFQEPRLalDPVYTVGRQIEETI-MRHEKVSRGLaaeralalfqkvripsperrlsnyphemSGGMLQRAMIAMA 171
Cdd:cd03233   85 --IIYVSEEDVH--FPTLTVRETLDFALrCKGNEFVRGI----------------------------SGGERKRVSIAEA 132

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 523689182 172 LACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAA-EVADRIAVMYAGRIV 237
Cdd:cd03233  133 LVSRASVLCWDNSTRGLDSSTALEILKCIRTMADVLKTTTFVSLYQASDEIyDLFDKVLVLYEGRQI 199

ABCG_EPDR

cd03213

Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette ...

9-240

3.27e-19

Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR). DR is a well-described phenomenon occurring in fungi and shares several similarities with processes in bacteria and higher eukaryotes. Compared to other members of the ABC transporter subfamilies, the ABCG transporter family is composed of proteins that have an ATP-binding cassette domain at the N-terminus and a TM (transmembrane) domain at the C-terminus.

Pssm-ID: 213180 [Multi-domain] Cd Length: 194 Bit Score: 83.75 E-value: 3.27e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTFRRG-GKAVKAV-NGVSLSVKPGEVVALLGESGSGKSVTMRSLL-RLHPKGtlIEGGMTVDGHDIMSLSNR 85
Cdd:cd03213    4 LSFRNLTVTVKSSpSKSGKQLlKNVSGKAKPGELTAIMGPSGAGKSTLLNALAgRRTGLG--VSGEVLINGRPLDKRSFR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  86 ALSdlrgavvSMVFQEprLALDPVYTVgrqiEETIMRHEKVsRGLaaeralalfqkvripsperrlsnyphemSGGMLQR 165
Cdd:cd03213   82 KII-------GYVPQD--DILHPTLTV----RETLMFAAKL-RGL----------------------------SGGERKR 119

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 523689182 166 AMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDigVAAEV---ADRIAVMYAGRIVEEG 240
Cdd:cd03213  120 VSIALELVSNPSLLFLDEPTSGLDSSSALQVMSLLRRLADT-GRTIICSIHQ--PSSEIfelFDKLLLLSQGRVIYFG 194

ABCC_Glucan_exporter_like

cd03254

ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Glucan ...

9-240

4.67e-19

ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virulence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and lipid export. The MRP-like family, similar to all ABC proteins, have a common four-domain core structure constituted by two membrane-spanning domains each composed of six transmembrane (TM) helices and two nucleotide-binding domains (NBD). ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213221 [Multi-domain] Cd Length: 229 Bit Score: 84.20 E-value: 4.67e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTFRRGGKAVKavnGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGtliEGGMTVDGHDIMSLSNRALS 88
Cdd:cd03254    3 IEFENVNFSYDEKKPVLK---DINFSIKPGETVAIVGPTGAGKTTLINLLMRFYDPQ---KGQILIDGIDIRDISRKSLR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  89 DLrgavVSMVFQEPRLaldpvytvgrqIEETIMRHEKVSRGLA-AERALALFQKVRIPSPERRLSN-YPHEMS--GGML- 163
Cdd:cd03254   77 SM----IGVVLQDTFL-----------FSGTIMENIRLGRPNAtDEEVIEAAKEAGAHDFIMKLPNgYDTVLGenGGNLs 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 164 --QRAMIAMALAC--NPKVLLADEPTTALDATVQIQILLLIRELQReyGLSVIFVTHDIGVAAEvADRIAVMYAGRIVEE 239
Cdd:cd03254  142 qgERQLLAIARAMlrDPKILILDEATSNIDTETEKLIQEALEKLMK--GRTSIIIAHRLSTIKN-ADKILVLDDGKIIEE 218


                 .
gi 523689182 240 G 240
Cdd:cd03254  219 G 219

PRK11831

phospholipid ABC transporter ATP-binding protein MlaF;

3-249

7.52e-19

phospholipid ABC transporter ATP-binding protein MlaF;

Pssm-ID: 236997 [Multi-domain] Cd Length: 269 Bit Score: 84.43 E-value: 7.52e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   3 MQNDAMIDISNLSvtFRRGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSvtmrSLLRLHPKGTLIEGG-MTVDGHDIMS 81
Cdd:PRK11831   2 QSVANLVDMRGVS--FTRGNRCI--FDNISLTVPRGKITAIMGPSGIGKT----TLLRLIGGQIAPDHGeILFDGENIPA 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  82 LSNRALSDLRGAVvSMVFQEPRLALDpvYTVGRQIEETIMRHEKVSRGLAAERALALFQKVRIPSPERRLsnyPHEMSGG 161
Cdd:PRK11831  74 MSRSRLYTVRKRM-SMLFQSGALFTD--MNVFDNVAYPLREHTQLPAPLLHSTVMMKLEAVGLRGAAKLM---PSELSGG 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 162 MLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGL 241
Cdd:PRK11831 148 MARRAALARAIALEPDLIMFDEPFVGQDPITMGVLVKLISELNSALGVTCVVVSHDVPEVLSIADHAYIVADKKIVAHGS 227


                 ....*...
gi 523689182 242 VGDIIRNP 249
Cdd:PRK11831 228 AQALQANP 235

met_CoM_red_A2

TIGR03269

methyl coenzyme M reductase system, component A2; The enzyme that catalyzes the final step in ...

9-240

2.80e-18

Pssm-ID: 132313 [Multi-domain] Cd Length: 520 Bit Score: 85.24 E-value: 2.80e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182    9 IDISNLSVTFrrggKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSL----------------LRLHPKGTLIE--- 69
Cdd:TIGR03269   1 IEVKNLTKKF----DGKEVLKNISFTIEEGEVLGILGRSGAGKSVLMHVLrgmdqyeptsgriiyhVALCEKCGYVErps 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   70 ----------GGMTVDGHDIMSLSNRALSDLRGAVVSMvFQEPrLALdpvYTVGRQIEETIMRHEKV--SRGLAAERALA 137
Cdd:TIGR03269  77 kvgepcpvcgGTLEPEEVDFWNLSDKLRRRIRKRIAIM-LQRT-FAL---YGDDTVLDNVLEALEEIgyEGKEAVGRAVD 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  138 LFQKVRIpspERRLSNYPHEMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHD 217
Cdd:TIGR03269 152 LIEMVQL---SHRITHIARDLSGGEKQRVVLARQLAKEPFLFLADEPTGTLDPQTAKLVHNALEEAVKASGISMVLTSHW 228

                         250       260
                  ....*....|....*....|...
gi 523689182  218 IGVAAEVADRIAVMYAGRIVEEG 240
Cdd:TIGR03269 229 PEVIEDLSDKAIWLENGEIKEEG 251

3a01208

TIGR00958

Conjugate Transporter-2 (CT2) Family protein; [Transport and binding proteins, Other]

30-240

3.32e-18

Conjugate Transporter-2 (CT2) Family protein; [Transport and binding proteins, Other]

Pssm-ID: 273363 [Multi-domain] Cd Length: 711 Bit Score: 85.16 E-value: 3.32e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   30 GVSLSVKPGEVVALLGESGSGKSVTMRSLLRLH-PKGtlieGGMTVDGHDIMSLSNRALSdlrgAVVSMVFQEPRLaldp 108
Cdd:TIGR00958 499 GLTFTLHPGEVVALVGPSGSGKSTVAALLQNLYqPTG----GQVLLDGVPLVQYDHHYLH----RQVALVGQEPVL---- 566

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  109 vytVGRQIEETIM----RHEKVSRGLAAERALAlfqkvripspERRLSNYPH-----------EMSGGMLQRAMIAMALA 173
Cdd:TIGR00958 567 ---FSGSVRENIAygltDTPDEEIMAAAKAANA----------HDFIMEFPNgydtevgekgsQLSGGQKQRIAIARALV 633

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 523689182  174 CNPKVLLADEPTTALDATVQiqilLLIRELQREYGLSVIFVTHDIGVaAEVADRIAVMYAGRIVEEG 240
Cdd:TIGR00958 634 RKPRVLILDEATSALDAECE----QLLQESRSRASRTVLLIAHRLST-VERADQILVLKKGSVVEMG 695

livF

PRK11614

high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF;

7-239

5.30e-18

high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF;

Pssm-ID: 183231 [Multi-domain] Cd Length: 237 Bit Score: 81.46 E-value: 5.30e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   7 AMIDISNLSVTFrrgGKaVKAVNGVSLSVKPGEVVALLGESGSGKSvTMRSLLRLHPKGTliEGGMTVDGHDIMSLSNRA 86
Cdd:PRK11614   4 VMLSFDKVSAHY---GK-IQALHEVSLHINQGEIVTLIGANGAGKT-TLLGTLCGDPRAT--SGRIVFDGKDITDWQTAK 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  87 LSDLRGAVV-------SMVFQEPRLALDPVYTVGRQIEETImrhekvsrglaaERALALFQKVRipspERRLSNyPHEMS 159
Cdd:PRK11614  77 IMREAVAIVpegrrvfSRMTVEENLAMGGFFAERDQFQERI------------KWVYELFPRLH----ERRIQR-AGTMS 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 160 GGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELqREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEE 239
Cdd:PRK11614 140 GGEQQMLAIGRALMSQPRLLLLDEPSLGLAPIIIQQIFDTIEQL-REQGMTIFLVEQNANQALKLADRGYVLENGHVVLE 218

ABCC_Protease_Secretion

cd03246

ATP-binding cassette domain of PrtD, subfamily C; This family represents the ABC component of ...

16-236

5.45e-18

ATP-binding cassette domain of PrtD, subfamily C; This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export degradative enzymes by using a type I protein secretion system and lack an N-terminal signal peptide, but contain a C-terminal secretion signal. The Type I secretion apparatus is made up of three components, an ABC transporter, a membrane fusion protein (MFP), and an outer membrane protein (OMP). For the HlyA transporter complex, HlyB (ABC transporter) and HlyD (MFP) reside in the inner membrane of E. coli. The OMP component is TolC, which is thought to interact with the MFP to form a continuous channel across the periplasm from the cytoplasm to the exterior. HlyB belongs to the family of ABC transporters, which are ubiquitous, ATP-dependent transmembrane pumps or channels. The spectrum of transport substrates ranges from inorganic ions, nutrients such as amino acids, sugars, or peptides, hydrophobic drugs, to large polypeptides, such as HlyA.

Pssm-ID: 213213 [Multi-domain] Cd Length: 173 Bit Score: 79.95 E-value: 5.45e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  16 VTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGtliEGGMTVDGHDImslsNRALSDLRGAVV 95
Cdd:cd03246    6 VSFRYPGAEPPVLRNVSFSIEPGESLAIIGPSGSGKSTLARLILGLLRPT---SGRVRLDGADI----SQWDPNELGDHV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  96 SMVFQEPRLaldpvytvgrqIEETImrhekvsrglaAERALalfqkvripsperrlsnyphemSGGMLQRAMIAMALACN 175
Cdd:cd03246   79 GYLPQDDEL-----------FSGSI-----------AENIL----------------------SGGQRQRLGLARALYGN 114

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 523689182 176 PKVLLADEPTTALDATVQIQILLLIRELqREYGLSVIFVTHDIGVAAEvADRIAVMYAGRI 236
Cdd:cd03246  115 PRILVLDEPNSHLDVEGERALNQAIAAL-KAAGATRIVIAHRPETLAS-ADRILVLEDGRV 173

TagH

COG1134

ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate ...

8-247

5.76e-18

ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism];

Pssm-ID: 440749 [Multi-domain] Cd Length: 245 Bit Score: 81.67 E-value: 5.76e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSVTFRRGGKA------------------VKAVNGVSLSVKPGEVVALLGESGSGKSvtmrSLLRL-----HP- 63
Cdd:COG1134    4 MIEVENVSKSYRLYHEPsrslkelllrrrrtrreeFWALKDVSFEVERGESVGIIGRNGAGKS----TLLKLiagilEPt 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  64 KGTLIeggmtvdghdimslsnralsdLRGAVVSMVfqEPRLALDP-------VYTVGRqieetIMrhekvsrGLAAERAL 136
Cdd:COG1134   80 SGRVE---------------------VNGRVSALL--ELGAGFHPeltgrenIYLNGR-----LL-------GLSRKEID 124

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 137 ALFQKVR--------IPSPerrLSNYphemSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREyG 208
Cdd:COG1134  125 EKFDEIVefaelgdfIDQP---VKTY----SSGMRARLAFAVATAVDPDILLVDEVLAVGDAAFQKKCLARIRELRES-G 196

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 523689182 209 LSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDIIR 247
Cdd:COG1134  197 RTVIFVSHSMGAVRRLCDRAIWLEKGRLVMDGDPEEVIA 235

PRK09984

phosphonate ABC transporter ATP-binding protein;

3-240

5.91e-18

phosphonate ABC transporter ATP-binding protein;

Pssm-ID: 182182 [Multi-domain] Cd Length: 262 Bit Score: 81.98 E-value: 5.91e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   3 MQNdaMIDISNLSVTFRRGgkavKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLlrlhpkGTLIEGGMTVDGH----- 77
Cdd:PRK09984   1 MQT--IIRVEKLAKTFNQH----QALHAVDLNIHHGEMVALLGPSGSGKSTLLRHL------SGLITGDKSAGSHiellg 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  78 DIMSLSNRALSDLRG--AVVSMVFQE----PRLALDPVYTVG--------RQIEETIMRHEKvsrglaaERALALFQKVR 143
Cdd:PRK09984  69 RTVQREGRLARDIRKsrANTGYIFQQfnlvNRLSVLENVLIGalgstpfwRTCFSWFTREQK-------QRALQALTRVG 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 144 IPS-PERRLSNypheMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAA 222
Cdd:PRK09984 142 MVHfAHQRVST----LSGGQQQRVAIARALMQQAKVILADEPIASLDPESARIVMDTLRDINQNDGITVVVTLHQVDYAL 217

                        250
                 ....*....|....*...
gi 523689182 223 EVADRIAVMYAGRIVEEG 240
Cdd:PRK09984 218 RYCERIVALRQGHVFYDG 235

ABCG_White

cd03234

White pigment protein homolog of ABCG transporter subfamily; The White subfamily represents ...

18-240

6.95e-18

White pigment protein homolog of ABCG transporter subfamily; The White subfamily represents ABC transporters homologous to the Drosophila white gene, which acts as a dimeric importer for eye pigment precursors. The eye pigmentation of Drosophila is developed from the synthesis and deposition in the cells of red pigments, which are synthesized from guanine, and brown pigments, which are synthesized from tryptophan. The pigment precursors are encoded by the white, brown, and scarlet genes, respectively. Evidence from genetic and biochemical studies suggest that the White and Brown proteins function as heterodimers to import guanine, while the White and Scarlet proteins function to import tryptophan. However, a recent study also suggests that White may be involved in the transport of a metabolite, such as 3-hydroxykynurenine, across intracellular membranes. Mammalian ABC transporters belonging to the White subfamily (ABCG1, ABCG5, and ABCG8) have been shown to be involved in the regulation of lipid-trafficking mechanisms in macrophages, hepatocytes, and intestinal mucosa cells. ABCG1 (ABC8), the human homolog of the Drosophila white gene is induced in monocyte-derived macrophages during cholesterol influx mediated by acetylated low-density lipoprotein. It is possible that human ABCG1 forms heterodimers with several heterologous partners.

Pssm-ID: 213201 [Multi-domain] Cd Length: 226 Bit Score: 80.78 E-value: 6.95e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  18 FRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGTLIEGGMTVDGhdimSLSNRALSDLRgavVSM 97
Cdd:cd03234   13 AKNWNKYARILNDVSLHVESGQVMAILGSSGSGKTTLLDAISGRVEGGGTTSGQILFNG----QPRKPDQFQKC---VAY 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  98 VFQEPRLAldPVYTVgrqiEETIM--------RH--EKVSRGLAAERALALFQKVRIPSPERRlsnyphEMSGGMLQRAM 167
Cdd:cd03234   86 VRQDDILL--PGLTV----RETLTytailrlpRKssDAIRKKRVEDVLLRDLALTRIGGNLVK------GISGGERRRVS 153

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 523689182 168 IAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAA-EVADRIAVMYAGRIVEEG 240
Cdd:cd03234  154 IAVQLLWDPKVLILDEPTSGLDSFTALNLVSTLSQLARR-NRIVILTIHQPRSDLfRLFDRILLLSSGEIVYSG 226

PRK13537

nodulation factor ABC transporter ATP-binding protein NodI;

7-246

9.25e-18

nodulation factor ABC transporter ATP-binding protein NodI;

Pssm-ID: 237420 [Multi-domain] Cd Length: 306 Bit Score: 82.16 E-value: 9.25e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   7 AMIDISNlsVTFRRGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRL-HPKGtlieGGMTVDGHDIMSLSNR 85
Cdd:PRK13537   6 APIDFRN--VEKRYGDKLV--VDGLSFHVQRGECFGLLGPNGAGKTTTLRMLLGLtHPDA----GSISLCGEPVPSRARH 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  86 ALSdlRGAVVsmvfqePRL-ALDPVYTVgRQIEETIMRHEKVSRGLAAERALALFQKVRIpspERRLSNYPHEMSGGMLQ 164
Cdd:PRK13537  78 ARQ--RVGVV------PQFdNLDPDFTV-RENLLVFGRYFGLSAAAARALVPPLLEFAKL---ENKADAKVGELSGGMKR 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 165 RAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGD 244
Cdd:PRK13537 146 RLTLARALVNDPDVLVLDEPTTGLDPQARHLMWERLRSLLAR-GKTILLTTHFMEEAERLCDRLCVIEEGRKIAEGAPHA 224


                 ..
gi 523689182 245 II 246
Cdd:PRK13537 225 LI 226

PRK11160

cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed

9-240

1.00e-17

cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed

Pssm-ID: 236865 [Multi-domain] Cd Length: 574 Bit Score: 83.72 E-value: 1.00e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNlsVTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSvtmrSLLRL-----HPKgtliEGGMTVDGHDIMSLS 83
Cdd:PRK11160 339 LTLNN--VSFTYPDQPQPVLKGLSLQIKAGEKVALLGRTGCGKS----TLLQLltrawDPQ----QGEILLNGQPIADYS 408

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  84 NralSDLRGAVvSMVFQEprlaldpVYTVGRQIEETIMrhekvsrgLAAERA-----LALFQKV---RIPSPERRLSNYP 155
Cdd:PRK11160 409 E---AALRQAI-SVVSQR-------VHLFSATLRDNLL--------LAAPNAsdealIEVLQQVgleKLLEDDKGLNAWL 469

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 156 HE----MSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQReyGLSVIFVTHDIgVAAEVADRIAVM 231
Cdd:PRK11160 470 GEggrqLSGGEQRRLGIARALLHDAPLLLLDEPTEGLDAETERQILELLAEHAQ--NKTVLMITHRL-TGLEQFDRICVM 546


                 ....*....
gi 523689182 232 YAGRIVEEG 240
Cdd:PRK11160 547 DNGQIIEQG 555

PRK13536

nodulation factor ABC transporter ATP-binding protein NodI;

9-246

2.30e-17

nodulation factor ABC transporter ATP-binding protein NodI;

Pssm-ID: 237419 [Multi-domain] Cd Length: 340 Bit Score: 81.42 E-value: 2.30e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTFrrGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGtliEGGMTVDGHDIMSLSNRALS 88
Cdd:PRK13536  42 IDLAGVSKSY--GDKAV--VNGLSFTVASGECFGLLGPNGAGKSTIARMILGMTSPD---AGKITVLGVPVPARARLARA 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  89 dlRGAVVSMvFQEprlaLDPVYTVgrqiEETIMRHEKVSRGLAAERALALFQKVRIPSPERRLSNYPHEMSGGMLQRAMI 168
Cdd:PRK13536 115 --RIGVVPQ-FDN----LDLEFTV----RENLLVFGRYFGMSTREIEAVIPSLLEFARLESKADARVSDLSGGMKRRLTL 183

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 523689182 169 AMALACNPKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDII 246
Cdd:PRK13536 184 ARALINDPQLLILDEPTTGLDPHARHLIWERLRSLLAR-GKTILLTTHFMEEAERLCDRLCVLEAGRKIAEGRPHALI 260

PRK10790

SmdB family multidrug efflux ABC transporter permease/ATP-binding protein;

9-240

2.70e-17

SmdB family multidrug efflux ABC transporter permease/ATP-binding protein;

Pssm-ID: 182733 [Multi-domain] Cd Length: 592 Bit Score: 82.46 E-value: 2.70e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTFRRGGKAVKAVNgvsLSVKPGEVVALLGESGSGKSvTMRSLLR-LHPkgtLIEGGMTVDGHDIMSLSNRAL 87
Cdd:PRK10790 341 IDIDNVSFAYRDDNLVLQNIN---LSVPSRGFVALVGHTGSGKS-TLASLLMgYYP---LTEGEIRLDGRPLSSLSHSVL 413

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  88 SDlrgaVVSMVFQEPRLALDPVY---TVGRQIEEtimrhEKVSRGLAAERaLALFQKVRIPSPERRLSNYPHEMSGGmlQ 164
Cdd:PRK10790 414 RQ----GVAMVQQDPVVLADTFLanvTLGRDISE-----EQVWQALETVQ-LAELARSLPDGLYTPLGEQGNNLSVG--Q 481

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 523689182 165 RAMIAMA--LACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIfvTHDIGVAAEvADRIAVMYAGRIVEEG 240
Cdd:PRK10790 482 KQLLALArvLVQTPQILILDEATANIDSGTEQAIQQALAAVREHTTLVVI--AHRLSTIVE-ADTILVLHRGQAVEQG 556

PRK10762

D-ribose transporter ATP binding protein; Provisional

25-245

4.03e-17

D-ribose transporter ATP binding protein; Provisional

Pssm-ID: 236755 [Multi-domain] Cd Length: 501 Bit Score: 81.59 E-value: 4.03e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  25 VKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPK--GTLIEGGMTVdghdimSLSNRALSDLRGavVSMVFQEp 102
Cdd:PRK10762  17 VKALSGAALNVYPGRVMALVGENGAGKSTMMKVLTGIYTRdaGSILYLGKEV------TFNGPKSSQEAG--IGIIHQE- 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 103 rLALDPVYTVGRQIeetIMRHEKVSR-------GLAAErALALFQKVRIP-SPERRLSnyphEMSGGMLQRAMIAMALAC 174
Cdd:PRK10762  88 -LNLIPQLTIAENI---FLGREFVNRfgridwkKMYAE-ADKLLARLNLRfSSDKLVG----ELSIGEQQMVEIAKVLSF 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 523689182 175 NPKVLLADEPTTALDATVQIQILLLIRELqREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDI 245
Cdd:PRK10762 159 ESKVIIMDEPTDALTDTETESLFRVIREL-KSQGRGIVYISHRLKEIFEICDDVTVFRDGQFIAEREVADL 228

AztA

NF040873

zinc ABC transporter ATP-binding protein AztA;

27-231

4.29e-17

zinc ABC transporter ATP-binding protein AztA;

Pssm-ID: 468810 [Multi-domain] Cd Length: 191 Bit Score: 78.04 E-value: 4.29e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  27 AVNGVSLSVKPGEVVALLGESGSGKSVTMRSLlrlhpKGTLIEGGMTVDGHdimslsnralsdlRGAVVSMVFQepRLAL 106
Cdd:NF040873   7 VLHGVDLTIPAGSLTAVVGPNGSGKSTLLKVL-----AGVLRPTSGTVRRA-------------GGARVAYVPQ--RSEV 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 107 DP--------VYTVGRQIEETIMRHEKVSRGLAAERALAlfqKVRIpspeRRLSNYP-HEMSGGMLQRAMIAMALACNPK 177
Cdd:NF040873  67 PDslpltvrdLVAMGRWARRGLWRRLTRDDRAAVDDALE---RVGL----ADLAGRQlGELSGGQRQRALLAQGLAQEAD 139

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 523689182 178 VLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEvADRIAVM 231
Cdd:NF040873 140 LLLLDEPTTGLDAESRERIIALLAEEHAR-GATVVVVTHDLELVRR-ADPCVLL 191

SufC

COG0396

Fe-S cluster assembly ATPase SufC [Posttranslational modification, protein turnover, ...

11-240

5.02e-17

Fe-S cluster assembly ATPase SufC [Posttranslational modification, protein turnover, chaperones];

Pssm-ID: 440165 [Multi-domain] Cd Length: 245 Bit Score: 78.96 E-value: 5.02e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  11 ISNLSVTFrrGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSvTMRSLLRLHPKGTLIEGGMTVDGHDIMSLS--NRALs 88
Cdd:COG0396    3 IKNLHVSV--EGKEI--LKGVNLTIKPGEVHAIMGPNGSGKS-TLAKVLMGHPKYEVTSGSILLDGEDILELSpdERAR- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  89 dlRGavVSMVFQEP------------RLALdpvytvgrqieeTIMRHEKVSRGLAAERALALFQKVRIPspERRLSNYPH 156
Cdd:COG0396   77 --AG--IFLAFQYPveipgvsvsnflRTAL------------NARRGEELSAREFLKLLKEKMKELGLD--EDFLDRYVN 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 157 E-MSGGMLQRAMIAMALACNPKVLLADEPTTALDA-TVQIqILLLIRELQREyGLSVIFVTH------DIgvaaeVADRI 228
Cdd:COG0396  139 EgFSGGEKKRNEILQMLLLEPKLAILDETDSGLDIdALRI-VAEGVNKLRSP-DRGILIITHyqrildYI-----KPDFV 211

                        250
                 ....*....|..
gi 523689182 229 AVMYAGRIVEEG 240
Cdd:COG0396  212 HVLVDGRIVKSG 223

Uup

COG0488

ATPase components of ABC transporters with duplicated ATPase domains [General function ...

11-236

8.62e-17

ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only];

Pssm-ID: 440254 [Multi-domain] Cd Length: 520 Bit Score: 80.88 E-value: 8.62e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  11 ISNLSVTFrrGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSvtmrSLLRLhpkgtlIEGGMTVDGHDImSLSnralsdl 90
Cdd:COG0488    1 LENLSKSF--GGRPL--LDDVSLSINPGDRIGLVGRNGAGKS----TLLKI------LAGELEPDSGEV-SIP------- 58

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  91 RGAVVSMVFQEPRL------------ALDPVYTVGRQIEE----------TIMRHEKVSRGLAAE-------RALALFQK 141
Cdd:COG0488   59 KGLRIGYLPQEPPLdddltvldtvldGDAELRALEAELEEleaklaepdeDLERLAELQEEFEALggweaeaRAEEILSG 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 142 VRIPS--PERRLSnyphEMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVqiqILLLIRELQReYGLSVIFVTHDIG 219
Cdd:COG0488  139 LGFPEedLDRPVS----ELSGGWRRRVALARALLSEPDLLLLDEPTNHLDLES---IEWLEEFLKN-YPGTVLVVSHDRY 210

                        250
                 ....*....|....*..
gi 523689182 220 VAAEVADRIAVMYAGRI 236
Cdd:COG0488  211 FLDRVATRILELDRGKL 227

PRK10247

putative ABC transporter ATP-binding protein YbbL; Provisional

16-217

1.43e-16

putative ABC transporter ATP-binding protein YbbL; Provisional

Pssm-ID: 182331 [Multi-domain] Cd Length: 225 Bit Score: 77.45 E-value: 1.43e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  16 VTFRRGGKavKAVNGVSLSVKPGEVVALLGESGSGKSVTMR---SLLRlhPKgtliEGGMTVDGHDIMSLSNRALSDLrg 92
Cdd:PRK10247  13 VGYLAGDA--KILNNISFSLRAGEFKLITGPSGCGKSTLLKivaSLIS--PT----SGTLLFEGEDISTLKPEIYRQQ-- 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  93 avVSMVFQEPRLALDPVY---TVGRQIEETIMRHEKVSRGLAaeralalfqkvRIPSPERRLSNYPHEMSGGMLQRAMIA 169
Cdd:PRK10247  83 --VSYCAQTPTLFGDTVYdnlIFPWQIRNQQPDPAIFLDDLE-----------RFALPDTILTKNIAELSGGEKQRISLI 149

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 523689182 170 MALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHD 217
Cdd:PRK10247 150 RNLQFMPKVLLLDEITSALDESNKHNVNEIIHRYVREQNIAVLWVTHD 197

xylG

TIGR02633

D-xylose ABC transporter, ATP-binding protein; Several bacterial species have enzymes xylose ...

25-236

1.61e-16

Pssm-ID: 131681 [Multi-domain] Cd Length: 500 Bit Score: 79.87 E-value: 1.61e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   25 VKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGtlIEGGMTVDGHDImslSNRALSDLRGAVVSMVFQE-PR 103
Cdd:TIGR02633 273 RKRVDDVSFSLRRGEILGVAGLVGAGRTELVQALFGAYPGK--FEGNVFINGKPV---DIRNPAQAIRAGIAMVPEDrKR 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  104 LALDPVYTVGRQIEETIM-RHEKVSRGLAAERALALFQ-----KVRIPSPERRLSNypheMSGGMLQRAMIAMALACNPK 177
Cdd:TIGR02633 348 HGIVPILGVGKNITLSVLkSFCFKMRIDAAAELQIIGSaiqrlKVKTASPFLPIGR----LSGGNQQKAVLAKMLLTNPR 423

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 523689182  178 VLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAGRI 236
Cdd:TIGR02633 424 VLILDEPTRGVDVGAKYEIYKLINQLAQE-GVAIIVVSSELAEVLGLSDRVLVIGEGKL 481

3a01204

TIGR00955

The Eye Pigment Precursor Transporter (EPP) Family protein; [Transport and binding proteins, ...

29-240

3.12e-16

The Eye Pigment Precursor Transporter (EPP) Family protein; [Transport and binding proteins, Other]

Pssm-ID: 273361 [Multi-domain] Cd Length: 617 Bit Score: 79.32 E-value: 3.12e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   29 NGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGTLIEGGMTVDGHDIMSLSNRALSdlrgAVVsmvfQEPRLALdP 108
Cdd:TIGR00955  42 KNVSGVAKPGELLAVMGSSGAGKTTLMNALAFRSPKGVKGSGSVLLNGMPIDAKEMRAIS----AYV----QQDDLFI-P 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  109 VYTVGRQIeeTIMRHEKVSRGLAAE----------RALALF--QKVRIPSPERRLSnypheMSGGMLQRAMIAMALACNP 176
Cdd:TIGR00955 113 TLTVREHL--MFQAHLRMPRRVTKKekrervdevlQALGLRkcANTRIGVPGRVKG-----LSGGERKRLAFASELLTDP 185

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 523689182  177 KVLLADEPTTALDATVQIQILLLIREL-QReyGLSVIFVTH----DIgvaAEVADRIAVMYAGRIVEEG 240
Cdd:TIGR00955 186 PLLFCDEPTSGLDSFMAYSVVQVLKGLaQK--GKTIICTIHqpssEL---FELFDKIILMAEGRVAYLG 249

ATM1

COG5265

ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components ...

29-240

3.62e-16

ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones];

Pssm-ID: 444078 [Multi-domain] Cd Length: 605 Bit Score: 79.09 E-value: 3.62e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  29 NGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLH-PKGtlieGGMTVDGHDIMSLSnraLSDLRGAVvSMVFQEPRLALD 107
Cdd:COG5265  375 KGVSFEVPAGKTVAIVGPSGAGKSTLARLLFRFYdVTS----GRILIDGQDIRDVT---QASLRAAI-GIVPQDTVLFND 446

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 108 pvyTVGRQI--------EETIMRhekvsrglAAERA------LALFQKVRIPSPERRLsnyphEMSGGMLQRAMIAMALA 173
Cdd:COG5265  447 ---TIAYNIaygrpdasEEEVEA--------AARAAqihdfiESLPDGYDTRVGERGL-----KLSGGEKQRVAIARTLL 510

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 523689182 174 CNPKVLLADEPTTALDATVQIQILLLIRELQReyGLSVIFVTHDIGVAAEvADRIAVMYAGRIVEEG 240
Cdd:COG5265  511 KNPPILIFDEATSALDSRTERAIQAALREVAR--GRTTLVIAHRLSTIVD-ADEILVLEAGRIVERG 574

PRK13549

xylose transporter ATP-binding subunit; Provisional

25-236

3.68e-16

xylose transporter ATP-binding subunit; Provisional

Pssm-ID: 184134 [Multi-domain] Cd Length: 506 Bit Score: 78.82 E-value: 3.68e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  25 VKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGTliEGGMTVDGHDImslSNRALSDLRGAVVSMVFQE-PR 103
Cdd:PRK13549 275 IKRVDDVSFSLRRGEILGIAGLVGAGRTELVQCLFGAYPGRW--EGEIFIDGKPV---KIRNPQQAIAQGIAMVPEDrKR 349

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 104 LALDPVYTVGRQIeeTIMRHEKVSRG----LAAERALALFQ----KVRIPSPERRLSNypheMSGGMLQRAMIAMALACN 175
Cdd:PRK13549 350 DGIVPVMGVGKNI--TLAALDRFTGGsridDAAELKTILESiqrlKVKTASPELAIAR----LSGGNQQKAVLAKCLLLN 423

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 523689182 176 PKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAGRI 236
Cdd:PRK13549 424 PKILILDEPTRGIDVGAKYEIYKLINQLVQQ-GVAIIVISSELPEVLGLSDRVLVMHEGKL 483

ABCC_NFT1

cd03369

ATP-binding cassette domain 2 of NFT1, subfamily C; Domain 2 of NFT1 (New full-length MRP-type ...

6-240

1.20e-15

ATP-binding cassette domain 2 of NFT1, subfamily C; Domain 2 of NFT1 (New full-length MRP-type transporter 1). NFT1 belongs to the MRP (multidrug resistance-associated protein) family of ABC transporters. Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional membrane-spanning domains is not clear. The MRP was found in the multidrug-resisting lung cancer cell in which p-glycoprotein was not overexpressed. MRP exports glutathione by drug stimulation, as well as, certain substrates in conjugated forms with anions such as glutathione, glucuronate, and sulfate.

Pssm-ID: 213269 [Multi-domain] Cd Length: 207 Bit Score: 74.37 E-value: 1.20e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   6 DAMIDISNLSVtfRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHpkgTLIEGGMTVDGHDIMSLSnr 85
Cdd:cd03369    4 HGEIEVENLSV--RYAPDLPPVLKNVSFKVKAGEKIGIVGRTGAGKSTLILALFRFL---EAEEGKIEIDGIDISTIP-- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  86 aLSDLRGAvVSMVFQEP-------RLALDPvytVGRQIEETIMRHEKVSRGlaaeralalfqkvripsperrLSNypheM 158
Cdd:cd03369   77 -LEDLRSS-LTIIPQDPtlfsgtiRSNLDP---FDEYSDEEIYGALRVSEG---------------------GLN----L 126

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 159 SGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQReyGLSVIFVTHDIGVAAEVaDRIAVMYAGRIVE 238
Cdd:cd03369  127 SQGQRQLLCLARALLKRPRVLVLDEATASIDYATDALIQKTIREEFT--NSTILTIAHRLRTIIDY-DKILVMDAGEVKE 203


                 ..
gi 523689182 239 EG 240
Cdd:cd03369  204 YD 205

CydC

TIGR02868

thiol reductant ABC exporter, CydC subunit; The gene pair cydCD encodes an ABC-family ...

16-217

1.43e-15

thiol reductant ABC exporter, CydC subunit; The gene pair cydCD encodes an ABC-family transporter in which each gene contains an N-terminal membrane-spanning domain (pfam00664) and a C-terminal ATP-binding domain (pfam00005). In E. coli these genes were discovered as mutants which caused the terminal heme-copper oxidase complex cytochrome bd to fail to assemble. Recent work has shown that the transporter is involved in export of redox-active thiol compounds such as cysteine and glutathione. The linkage to assembly of the cytochrome bd complex is further supported by the conserved operon structure found outside the gammaproteobacteria (cydABCD) containing both the transporter and oxidase genes components. The genes used as the seed members for this model are all either found in the gammproteobacterial context or the CydABCD context. All members of this family scoring above trusted at the time of its creation were from genomes which encode a cytochrome bd complex.

Pssm-ID: 274331 [Multi-domain] Cd Length: 530 Bit Score: 77.02 E-value: 1.43e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   16 VTFRRGGKAVkAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKgtlIEGGMTVDGHDIMSLSNRALSdlrgAVV 95
Cdd:TIGR02868 340 LSAGYPGAPP-VLDGVSLDLPPGERVAILGPSGSGKSTLLATLAGLLDP---LQGEVTLDGVPVSSLDQDEVR----RRV 411

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   96 SMVFQEPRLaldpvytvgrqIEETIMRHEKVSRGLAA-ERALALFQKVRIPSPERRL----SNYPHEM----SGGMLQRA 166
Cdd:TIGR02868 412 SVCAQDAHL-----------FDTTVRENLRLARPDATdEELWAALERVGLADWLRALpdglDTVLGEGgarlSGGERQRL 480

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 523689182  167 MIAMALACNPKVLLADEPTTALDATVQIQILLLIreLQREYGLSVIFVTHD 217
Cdd:TIGR02868 481 ALARALLADAPILLLDEPTEHLDAETADELLEDL--LAALSGRTVVLITHH 529

araG

PRK11288

L-arabinose ABC transporter ATP-binding protein AraG;

13-238

1.83e-15

L-arabinose ABC transporter ATP-binding protein AraG;

Pssm-ID: 183077 [Multi-domain] Cd Length: 501 Bit Score: 76.87 E-value: 1.83e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  13 NLSVTFrrggKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGTlieGGMTVDGHDIMSLSNRALSDlrg 92
Cdd:PRK11288   9 GIGKTF----PGVKALDDISFDCRAGQVHALMGENGAGKSTLLKILSGNYQPDA---GSILIDGQEMRFASTTAALA--- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  93 AVVSMVFQEprLALDPVYTVGrqieETIM------RHEKVSRGLAAERALALFQK--VRIpSPERRLSnyphEMSGGmlQ 164
Cdd:PRK11288  79 AGVAIIYQE--LHLVPEMTVA----ENLYlgqlphKGGIVNRRLLNYEAREQLEHlgVDI-DPDTPLK----YLSIG--Q 145

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 523689182 165 RAM--IAMALACNPKVLLADEPTTALDATvQIQILL-LIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAGRIVE 238
Cdd:PRK11288 146 RQMveIAKALARNARVIAFDEPTSSLSAR-EIEQLFrVIRELRAE-GRVILYVSHRMEEIFALCDAITVFKDGRYVA 220

ABCF_EF-3

cd03221

ATP-binding cassette domain of elongation factor 3, subfamily F; Elongation factor 3 (EF-3) is ...

9-231

2.00e-15

ATP-binding cassette domain of elongation factor 3, subfamily F; Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated release of the deacylated tRNA from the E site. The reaction requires ATP hydrolysis. EF-3 contains two ATP nucleotide binding sequence (NBS) motifs. NBSI is sufficient for the intrinsic ATPase activity. NBSII is essential for the ribosome-stimulated functions.

Pssm-ID: 213188 [Multi-domain] Cd Length: 144 Bit Score: 72.10 E-value: 2.00e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTFrrGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSvtmrSLLRLhpkgtlIEGGMTVDghdimslsnrals 88
Cdd:cd03221    1 IELENLSKTY--GGKLL--LKDISLTINPGDRIGLVGRNGAGKS----TLLKL------IAGELEPD------------- 53

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  89 dlrgavvsmvfqEPRLALDPVYTVGrqieetimrhekvsrglaaeralalfqkvripsperrlsnYPHEMSGGMLQRAMI 168
Cdd:cd03221   54 ------------EGIVTWGSTVKIG----------------------------------------YFEQLSGGEKMRLAL 81

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 523689182 169 AMALACNPKVLLADEPTTALDATvqiQILLLIRELQREYGlSVIFVTHDIGVAAEVADRIAVM 231
Cdd:cd03221   82 AKLLLENPNLLLLDEPTNHLDLE---SIEALEEALKEYPG-TVILVSHDRYFLDQVATKIIEL 140

ABC_KpsT_Wzt

cd03220

ATP-binding cassette component of polysaccharide transport system; The KpsT/Wzt ABC ...

9-240

2.75e-15

ATP-binding cassette component of polysaccharide transport system; The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and teichoic acids have been shown to be exported by ABC transporters. A typical system is made of a conserved integral membrane and an ABC. In addition to these proteins, capsular polysaccharide exporter systems require two 'accessory' proteins to perform their function: a periplasmic (E.coli) or a lipid-anchored outer membrane protein called OMA (Neisseria meningitidis and Haemophilus influenza) and a cytoplasmic membrane protein MPA2.

Pssm-ID: 213187 [Multi-domain] Cd Length: 224 Bit Score: 73.72 E-value: 2.75e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTFRRGGKA------------------VKAVNGVSLSVKPGEVVALLGESGSGKSvtmrSLLRLhpkgtlIEG 70
Cdd:cd03220    1 IELENVSKSYPTYKGGssslkklgilgrkgevgeFWALKDVSFEVPRGERIGLIGRNGAGKS----TLLRL------LAG 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  71 GMTVDGHDImslsnralsDLRGAVVSMVfqEPRLALDPVYTvGRqiEETIMRHekVSRGLAAERALALFQKV-------- 142
Cdd:cd03220   71 IYPPDSGTV---------TVRGRVSSLL--GLGGGFNPELT-GR--ENIYLNG--RLLGLSRKEIDEKIDEIiefselgd 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 143 RIPSPERRLSNyphemsgGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAA 222
Cdd:cd03220  135 FIDLPVKTYSS-------GMKARLAFAIATALEPDILLIDEVLAVGDAAFQEKCQRRLRELLKQ-GKTVILVSHDPSSIK 206

                        250
                 ....*....|....*...
gi 523689182 223 EVADRIAVMYAGRIVEEG 240
Cdd:cd03220  207 RLCDRALVLEKGKIRFDG 224

PRK10762

D-ribose transporter ATP binding protein; Provisional

28-239

3.12e-15

D-ribose transporter ATP binding protein; Provisional

Pssm-ID: 236755 [Multi-domain] Cd Length: 501 Bit Score: 76.20 E-value: 3.12e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  28 VNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGtliEGGMTVDGHDIMSLSNRA--------LSDLR---GAVVS 96
Cdd:PRK10762 268 VNDVSFTLRKGEILGVSGLMGAGRTELMKVLYGALPRT---SGYVTLDGHEVVTRSPQDglangivyISEDRkrdGLVLG 344

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  97 MVFQE--PRLALDPVYTVGRQIeetimRHEKvsRGLAAERALALFqKVRIPSPERRLSNypheMSGGMLQRAMIAMALAC 174
Cdd:PRK10762 345 MSVKEnmSLTALRYFSRAGGSL-----KHAD--EQQAVSDFIRLF-NIKTPSMEQAIGL----LSGGNQQKVAIARGLMT 412

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 523689182 175 NPKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEE 239
Cdd:PRK10762 413 RPKVLILDEPTRGVDVGAKKEIYQLINQFKAE-GLSIILVSSEMPEVLGMSDRILVMHEGRISGE 476

cbiO

PRK13638

energy-coupling factor ABC transporter ATP-binding protein;

28-245

3.53e-15

energy-coupling factor ABC transporter ATP-binding protein;

Pssm-ID: 184198 [Multi-domain] Cd Length: 271 Bit Score: 74.27 E-value: 3.53e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  28 VNGVSLSVKPGEVVALLGESGSGKS---VTMRSLLRLHpKGTLIEGGMTVDghdimsLSNRALSDLRGAVVSmVFQEPRL 104
Cdd:PRK13638  17 LKGLNLDFSLSPVTGLVGANGCGKStlfMNLSGLLRPQ-KGAVLWQGKPLD------YSKRGLLALRQQVAT-VFQDPEQ 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 105 ALdpVYTvgrQIEETI---MRHEKVSRGLAAER---ALALFQKvripspeRRLSNYPHE-MSGGMLQRAMIAMALACNPK 177
Cdd:PRK13638  89 QI--FYT---DIDSDIafsLRNLGVPEAEITRRvdeALTLVDA-------QHFRHQPIQcLSHGQKKRVAIAGALVLQAR 156

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 523689182 178 VLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDI 245
Cdd:PRK13638 157 YLLLDEPTAGLDPAGRTQMIAIIRRIVAQ-GNHVIISSHDIDLIYEISDAVYVLRQGQILTHGAPGEV 223

PRK15056

manganese/iron ABC transporter ATP-binding protein;

3-240

1.48e-14

manganese/iron ABC transporter ATP-binding protein;

Pssm-ID: 185016 [Multi-domain] Cd Length: 272 Bit Score: 72.61 E-value: 1.48e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   3 MQNDAMIDISNLSVTFRRGGKAVKavnGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHpkgTLIEGGMTVDGHDImsl 82
Cdd:PRK15056   1 MMQQAGIVVNDVTVTWRNGHTALR---DASFTVPGGSIAALVGVNGSGKSTLFKALMGFV---RLASGKISILGQPT--- 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  83 sNRALsdlRGAVVSMVFQE-------PRLALDpVYTVGRQIEETIMRHEKVSRGLAAERALAlfqkvRIPSPERRLSNYp 155
Cdd:PRK15056  72 -RQAL---QKNLVAYVPQSeevdwsfPVLVED-VVMMGRYGHMGWLRRAKKRDRQIVTAALA-----RVDMVEFRHRQI- 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 156 HEMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELqREYGLSVIFVTHDIGVAAEVADrIAVMYAGR 235
Cdd:PRK15056 141 GELSGGQKKRVFLARAIAQQGQVILLDEPFTGVDVKTEARIISLLREL-RDEGKTMLVSTHNLGSVTEFCD-YTVMVKGT 218


                 ....*
gi 523689182 236 IVEEG 240
Cdd:PRK15056 219 VLASG 223

PRK09700

D-allose ABC transporter ATP-binding protein AlsA;

22-239

2.20e-14

D-allose ABC transporter ATP-binding protein AlsA;

Pssm-ID: 182036 [Multi-domain] Cd Length: 510 Bit Score: 73.67 E-value: 2.20e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  22 GKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKgtlIEGGMTVDGHDImslsnralsdlrgavvsmvfqE 101
Cdd:PRK09700 273 SRDRKKVRDISFSVCRGEILGFAGLVGSGRTELMNCLFGVDKR---AGGEIRLNGKDI---------------------S 328

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 102 PRLALDPVYTVGRQIEE-----------TIMRHEKVSRGLAAER---ALALFQKV---RIPSPERRLSNYP--------H 156
Cdd:PRK09700 329 PRSPLDAVKKGMAYITEsrrdngffpnfSIAQNMAISRSLKDGGykgAMGLFHEVdeqRTAENQRELLALKchsvnqniT 408

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 157 EMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAGRI 236
Cdd:PRK09700 409 ELSGGNQQKVLISKWLCCCPEVIIFDEPTRGIDVGAKAEIYKVMRQLADD-GKVILMVSSELPEIITVCDRIAVFCEGRL 487


                 ...
gi 523689182 237 VEE 239
Cdd:PRK09700 488 TQI 490

znuC

PRK09544

high-affinity zinc transporter ATPase; Reviewed

8-218

1.81e-13

high-affinity zinc transporter ATPase; Reviewed

Pssm-ID: 181939 [Multi-domain] Cd Length: 251 Bit Score: 68.99 E-value: 1.81e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSVTFrrGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRL-HPKGTLIEggmtvdghdimslsnra 86
Cdd:PRK09544   4 LVSLENVSVSF--GQRRV--LSDVSLELKPGKILTLLGPNGAGKSTLVRVVLGLvAPDEGVIK----------------- 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  87 lsdlRGAVVSMVFQEPRLALDPVYTVgrqieeTIMRHEKVSRGLAAERALALFQKVRipspERRLSNYP-HEMSGGMLQR 165
Cdd:PRK09544  63 ----RNGKLRIGYVPQKLYLDTTLPL------TVNRFLRLRPGTKKEDILPALKRVQ----AGHLIDAPmQKLSGGETQR 128

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 523689182 166 AMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDI 218
Cdd:PRK09544 129 VLLARALLNRPQLLVLDEPTQGVDVNGQVALYDLIDQLRRELDCAVLMVSHDL 181

araG

PRK11288

L-arabinose ABC transporter ATP-binding protein AraG;

31-239

2.02e-13

L-arabinose ABC transporter ATP-binding protein AraG;

Pssm-ID: 183077 [Multi-domain] Cd Length: 501 Bit Score: 70.71 E-value: 2.02e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  31 VSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKgtlIEGGMTVDGHDImslsnrALSDLRGAVVS--MVFQEPRLALD- 107
Cdd:PRK11288 272 ISFSVRAGEIVGLFGLVGAGRSELMKLLYGATRR---TAGQVYLDGKPI------DIRSPRDAIRAgiMLCPEDRKAEGi 342

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 108 -PVYTVGRQIEETIMRH---------EKVSRGLAAERALALfqKVRIPSPERRLSNypheMSGGMLQRAMIAMALACNPK 177
Cdd:PRK11288 343 iPVHSVADNINISARRHhlragclinNRWEAENADRFIRSL--NIKTPSREQLIMN----LSGGNQQKAILGRWLSEDMK 416

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 523689182 178 VLLADEPTTALDATVQIQILLLIRELQrEYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEE 239
Cdd:PRK11288 417 VILLDEPTRGIDVGAKHEIYNVIYELA-AQGVAVLFVSSDLPEVLGVADRIVVMREGRIAGE 477

PRK15439

autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional

31-246

2.81e-13

autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional

Pssm-ID: 185336 [Multi-domain] Cd Length: 510 Bit Score: 70.08 E-value: 2.81e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  31 VSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGTlieGGMTVDGHDIMSLSNRAL--------------------SDL 90
Cdd:PRK15439 282 ISLEVRAGEILGLAGVVGAGRTELAETLYGLRPARG---GRIMLNGKEINALSTAQRlarglvylpedrqssglyldAPL 358

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  91 RGAVVSMVFQEPRLALDPVYtvgrqiEETIMRHEKVSRGLAAERAlalfqkvriPSPERRLSnyphemsGGMLQRAMIAM 170
Cdd:PRK15439 359 AWNVCALTHNRRGFWIKPAR------ENAVLERYRRALNIKFNHA---------EQAARTLS-------GGNQQKVLIAK 416

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 523689182 171 ALACNPKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEgLVGDII 246
Cdd:PRK15439 417 CLEASPQLLIVDEPTRGVDVSARNDIYQLIRSIAAQ-NVAVLFISSDLEEIEQMADRVLVMHQGEISGA-LTGAAI 490

ABCG_PDR_domain2

cd03232

Second domain of the pleiotropic drug resistance-like (PDR) subfamily G of ATP-binding ...

12-216

3.79e-13

Second domain of the pleiotropic drug resistance-like (PDR) subfamily G of ATP-binding cassette transporters; The pleiotropic drug resistance (PDR) is a well-described phenomenon occurring in fungi and shares several similarities with processes in bacteria and higher eukaryotes. This PDR subfamily represents domain I of its (ABC-IM)2 organization. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.

Pssm-ID: 213199 [Multi-domain] Cd Length: 192 Bit Score: 66.88 E-value: 3.79e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  12 SNLSVTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGTlIEGGMTVDGHDIMSLSNRalsdlr 91
Cdd:cd03232    7 KNLNYTVPVKGGKRQLLNNISGYVKPGTLTALMGESGAGKTTLLDVLAGRKTAGV-ITGEILINGRPLDKNFQR------ 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  92 gaVVSMVFQEPrlALDPVYTVgrqiEETIMRHekvsrglAAERALALFQKvripspeRRLSnyphemsggmlqramIAMA 171
Cdd:cd03232   80 --STGYVEQQD--VHSPNLTV----REALRFS-------ALLRGLSVEQR-------KRLT---------------IGVE 122

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 523689182 172 LACNPKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTH 216
Cdd:cd03232  123 LAAKPSILFLDEPTSGLDSQAAYNIVRFLKKLADS-GQAILCTIH 166

YddA

COG4178

ABC-type uncharacterized transport system, permease and ATPase components [General function ...

4-216

4.41e-13

ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only];

Pssm-ID: 443337 [Multi-domain] Cd Length: 571 Bit Score: 69.45 E-value: 4.41e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   4 QNDAMIDISNLSVtFRRGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGTlieGGMTV-DGHDIMSL 82
Cdd:COG4178  358 SEDGALALEDLTL-RTPDGRPL--LEDLSLSLKPGERLLITGPSGSGKSTLLRAIAGLWPYGS---GRIARpAGARVLFL 431

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  83 SNRA---LSDLRGAVVSmvfqePRLAldpvytvgrqieetimrhEKVSRglaaERALALFQKVRIPSPERRLS---NYPH 156
Cdd:COG4178  432 PQRPylpLGTLREALLY-----PATA------------------EAFSD----AELREALEAVGLGHLAERLDeeaDWDQ 484

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 157 EMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRElqREYGLSVIFVTH 216
Cdd:COG4178  485 VLSLGEQQRLAFARLLLHKPDWLFLDEATSALDEENEAALYQLLRE--ELPGTTVISVGH 542

ArpD

COG4618

ABC-type protease/lipase transport system, ATPase and permease components [Intracellular ...

16-240

4.86e-13

ABC-type protease/lipase transport system, ATPase and permease components [Intracellular trafficking, secretion, and vesicular transport];

Pssm-ID: 443660 [Multi-domain] Cd Length: 563 Bit Score: 69.39 E-value: 4.86e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  16 VTFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPkgtLIEGGMTVDGHDImSLSNRalsDLRGAVV 95
Cdd:COG4618  336 LTVVPPGSKRPILRGVSFSLEPGEVLGVIGPSGSGKSTLARLLVGVWP---PTAGSVRLDGADL-SQWDR---EELGRHI 408

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  96 SMVFQEPRLaLDpvytvGRqIEETIMRH-----EKVSRglAAERALAlfqkvripsperrlsnypHEM------------ 158
Cdd:COG4618  409 GYLPQDVEL-FD-----GT-IAENIARFgdadpEKVVA--AAKLAGV------------------HEMilrlpdgydtri 461

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 159 -------SGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELqREYGLSVIFVTHDIGVAAeVADRIAVM 231
Cdd:COG4618  462 geggarlSGGQRQRIGLARALYGDPRLVVLDEPNSNLDDEGEAALAAAIRAL-KARGATVVVITHRPSLLA-AVDKLLVL 539


                 ....*....
gi 523689182 232 YAGRIVEEG 240
Cdd:COG4618  540 RDGRVQAFG 548

PRK10982

galactose/methyl galaxtoside transporter ATP-binding protein; Provisional

25-246

1.13e-12

galactose/methyl galaxtoside transporter ATP-binding protein; Provisional

Pssm-ID: 182880 [Multi-domain] Cd Length: 491 Bit Score: 68.22 E-value: 1.13e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  25 VKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGtliEGGMTVDGHDI-MSLSNRALSDlrgaVVSMVFQE-- 101
Cdd:PRK10982  11 VKALDNVNLKVRPHSIHALMGENGAGKSTLLKCLFGIYQKD---SGSILFQGKEIdFKSSKEALEN----GISMVHQEln 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 102 ---PRLALDPVYtVGRQIEETI-MRHEKVSRglaaeRALALFQKVRIP-SPERRLSNypheMSGGMLQRAMIAMALACNP 176
Cdd:PRK10982  84 lvlQRSVMDNMW-LGRYPTKGMfVDQDKMYR-----DTKAIFDELDIDiDPRAKVAT----LSVSQMQMIEIAKAFSYNA 153

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 523689182 177 KVLLADEPTTALDATVQIQILLLIRELqREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVE----EGLVGDII 246
Cdd:PRK10982 154 KIVIMDEPTSSLTEKEVNHLFTIIRKL-KERGCGIVYISHKMEEIFQLCDEITILRDGQWIAtqplAGLTMDKI 226

40850658_otr

NF000106

oxytetracycline efflux ABC transporter Otr(C) ATP-binding subunit;

25-245

1.87e-12

oxytetracycline efflux ABC transporter Otr(C) ATP-binding subunit;

Pssm-ID: 411078 [Multi-domain] Cd Length: 351 Bit Score: 67.07 E-value: 1.87e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  25 VKAVNGVSLSVKPGEVVALLGESGSGKSvtmRSLLRLHPKGTliEGGMTVDGHDIMSLSNRALSDLRGA--VVSMVFQEP 102
Cdd:NF000106  26 VKAVDGVDLDVREGTVLGVLGP*GAA**---RGALPAHV*GP--DAGRRPWRF*TWCANRRALRRTIG*hrPVR*GRRES 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 103 RLALDPVYTVGRQIEetimrhekVSRGLAAERALALFQKVRIPSPERRLSNyphEMSGGMLQRAMIAMALACNPKVLLAD 182
Cdd:NF000106 101 FSGRENLYMIGR*LD--------LSRKDARARADELLERFSLTEAAGRAAA---KYSGGMRRRLDLAASMIGRPAVLYLD 169

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 523689182 183 EPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDI 245
Cdd:NF000106 170 EPTTGLDPRTRNEVWDEVRSMVRD-GATVLLTTQYMEEAEQLAHELTVIDRGRVIADGKVDEL 231

PRK11174

cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed

31-240

2.26e-12

cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed

Pssm-ID: 236870 [Multi-domain] Cd Length: 588 Bit Score: 67.56 E-value: 2.26e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  31 VSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPkgtlIEGGMTVDGhdiMSLSNRALSDLRGAVvSMVFQEPRL----AL 106
Cdd:PRK11174 369 LNFTLPAGQRIALVGPSGAGKTSLLNALLGFLP----YQGSLKING---IELRELDPESWRKHL-SWVGQNPQLphgtLR 440

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 107 DPVyTVGR------QIEETIMR---HEKVSR---GLA---AERALALfqkvripsperrlsnyphemSGGMLQRAMIAMA 171
Cdd:PRK11174 441 DNV-LLGNpdasdeQLQQALENawvSEFLPLlpqGLDtpiGDQAAGL--------------------SVGQAQRLALARA 499

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 523689182 172 LACNPKVLLADEPTTALDATVQIQILLLIRELQReyGLSVIFVTHDIGVAAEVaDRIAVMYAGRIVEEG 240
Cdd:PRK11174 500 LLQPCQLLLLDEPTASLDAHSEQLVMQALNAASR--RQTTLMVTHQLEDLAQW-DQIWVMQDGQIVQQG 565

PRK11147

ABC transporter ATPase component; Reviewed

33-228

2.94e-12

ABC transporter ATPase component; Reviewed

Pssm-ID: 236861 [Multi-domain] Cd Length: 635 Bit Score: 67.28 E-value: 2.94e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  33 LSVKPGEVVALLGESGSGKSVTMRSLLRLHPkgtLIEGGMTVDGhdimslsnralsDLrgaVVSMVFQEP-RLALDPVYT 111
Cdd:PRK11147  24 LHIEDNERVCLVGRNGAGKSTLMKILNGEVL---LDDGRIIYEQ------------DL---IVARLQQDPpRNVEGTVYD 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 112 -VGRQIEET---IMRHEKVSRGLA---AERALALFQKV--------------RIP--------SPERRLSnyphEMSGGM 162
Cdd:PRK11147  86 fVAEGIEEQaeyLKRYHDISHLVEtdpSEKNLNELAKLqeqldhhnlwqlenRINevlaqlglDPDAALS----SLSGGW 161

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 523689182 163 LQRAMIAMALACNPKVLLADEPTTALDatvqIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRI 228
Cdd:PRK11147 162 LRKAALGRALVSNPDVLLLDEPTNHLD----IETIEWLEGFLKTFQGSIIFISHDRSFIRNMATRI 223

modC

PRK11144

molybdenum ABC transporter ATP-binding protein ModC;

40-242

3.76e-12

molybdenum ABC transporter ATP-binding protein ModC;

Pssm-ID: 182993 [Multi-domain] Cd Length: 352 Bit Score: 66.05 E-value: 3.76e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  40 VVALLGESGSGKSvtmrSLLrlhpkgTLIeGGMTVDGHDIMSLSNRALSDLRGAV--------VSMVFQEPRLAldPVYT 111
Cdd:PRK11144  26 ITAIFGRSGAGKT----SLI------NAI-SGLTRPQKGRIVLNGRVLFDAEKGIclppekrrIGYVFQDARLF--PHYK 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 112 VgrqieETIMRHekvsrGLAAERAlALFQK-VRIPSPERRLSNYPHEMSGGMLQRAMIAMALACNPKVLLADEPTTALDA 190
Cdd:PRK11144  93 V-----RGNLRY-----GMAKSMV-AQFDKiVALLGIEPLLDRYPGSLSGGEKQRVAIGRALLTAPELLLMDEPLASLDL 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 523689182 191 TVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLV 242
Cdd:PRK11144 162 PRKRELLPYLERLAREINIPILYVSHSLDEILRLADRVVVLEQGKVKAFGPL 213

MK0520

COG2401

ABC-type ATPase fused to a predicted acetyltransferase domain [General function prediction ...

7-216

1.90e-11

ABC-type ATPase fused to a predicted acetyltransferase domain [General function prediction only];

Pssm-ID: 441957 [Multi-domain] Cd Length: 222 Bit Score: 62.67 E-value: 1.90e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   7 AMIDISNLSVTFRRGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHpKGTLIEGgmTVDGHDIMSLSNRA 86
Cdd:COG2401   27 VAIVLEAFGVELRVVERYV--LRDLNLEIEPGEIVLIVGASGSGKSTLLRLLAGAL-KGTPVAG--CVDVPDNQFGREAS 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  87 LSDlrgavvsmvfqeprlALDPVYTVgrqieetimrhekvsrgLAAERALALFQKVRIPSPERRlsnyPHEMSGGMLQRA 166
Cdd:COG2401  102 LID---------------AIGRKGDF-----------------KDAVELLNAVGLSDAVLWLRR----FKELSTGQKFRF 145

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 523689182 167 MIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTH 216
Cdd:COG2401  146 RLALLLAERPKLLVIDEFCSHLDRQTAKRVARNLQKLARRAGITLVVATH 195

PRK10789

SmdA family multidrug ABC transporter permease/ATP-binding protein;

17-240

3.83e-11

SmdA family multidrug ABC transporter permease/ATP-binding protein;

Pssm-ID: 182732 [Multi-domain] Cd Length: 569 Bit Score: 63.58 E-value: 3.83e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  17 TFRRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSvTMRSLLRLHpkgtlieggMTVDGHDI----MSLSNRALSDLRG 92
Cdd:PRK10789 320 QFTYPQTDHPALENVNFTLKPGQMLGICGPTGSGKS-TLLSLIQRH---------FDVSEGDIrfhdIPLTKLQLDSWRS 389

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  93 --AVVSmvfQEPRLALDpvyTVGRQI-----EETIMRHEKVSRgLAA--ERALALFQKVRIPSPERRLSnypheMSGGML 163
Cdd:PRK10789 390 rlAVVS---QTPFLFSD---TVANNIalgrpDATQQEIEHVAR-LASvhDDILRLPQGYDTEVGERGVM-----LSGGQK 457

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 523689182 164 QRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQReyGLSVIFVTHDIGVAAEvADRIAVMYAGRIVEEG 240
Cdd:PRK10789 458 QRISIARALLLNAEILILDDALSAVDGRTEHQILHNLRQWGE--GRTVIISAHRLSALTE-ASEILVMQHGHIAQRG 531

Uup

COG0488

ATPase components of ABC transporters with duplicated ATPase domains [General function ...

8-238

1.18e-10

ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only];

Pssm-ID: 440254 [Multi-domain] Cd Length: 520 Bit Score: 62.00 E-value: 1.18e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSVTFrrGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSvtmrSLLRlhpkgtLIEGGMTVDGHDIMslsnral 87
Cdd:COG0488  315 VLELEGLSKSY--GDKTL--LDDLSLRIDRGDRIGLIGPNGAGKS----TLLK------LLAGELEPDSGTVK------- 373

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  88 sdlRGAVVSMVF--QEpRLALDPVYTVgrqiEETIMRH-----EKVSRGLAA------ERAlalFQKVRipsperrlsny 154
Cdd:COG0488  374 ---LGETVKIGYfdQH-QEELDPDKTV----LDELRDGapggtEQEVRGYLGrflfsgDDA---FKPVG----------- 431

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 155 phEMSGGmlQRA--MIAMALACNPKVLLADEPTTALD-ATVQIQILLLIrelqrEYGLSVIFVTHDIGVAAEVADRIAVM 231
Cdd:COG0488  432 --VLSGG--EKArlALAKLLLSPPNVLLLDEPTNHLDiETLEALEEALD-----DFPGTVLLVSHDRYFLDRVATRILEF 502


                 ....*..
gi 523689182 232 YAGRIVE 238
Cdd:COG0488  503 EDGGVRE 509

PRK15439

autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional

24-240

1.52e-10

autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional

Pssm-ID: 185336 [Multi-domain] Cd Length: 510 Bit Score: 61.99 E-value: 1.52e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  24 AVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGTlieGGMTVDGHDIMSLSNrALSDLRGavVSMVFQEPR 103
Cdd:PRK15439  23 GVEVLKGIDFTLHAGEVHALLGGNGAGKSTLMKIIAGIVPPDS---GTLEIGGNPCARLTP-AKAHQLG--IYLVPQEPL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 104 LAldPVYTVGRQIEETIMRHEKVSRGLAAerALALFQkvripsperrlSNYPHEMSGGML-----QRAMIAMALACNPKV 178
Cdd:PRK15439  97 LF--PNLSVKENILFGLPKRQASMQKMKQ--LLAALG-----------CQLDLDSSAGSLevadrQIVEILRGLMRDSRI 161

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 523689182 179 LLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEG 240
Cdd:PRK15439 162 LILDEPTASLTPAETERLFSRIRELLAQ-GVGIVFISHKLPEIRQLADRISVMRDGTIALSG 222

ABC_RNaseL_inhibitor_domain1

cd03236

The ATP-binding cassette domain 1 of RNase L inhibitor; The ABC ATPase, RNase L inhibitor (RLI) ...

34-232

3.37e-10

The ATP-binding cassette domain 1 of RNase L inhibitor; The ABC ATPase, RNase L inhibitor (RLI), is a key enzyme in ribosomal biogenesis, formation of translation preinitiation complexes, and assembly of HIV capsids. RLI s are not transport proteins and thus cluster with a group of soluble proteins that lack the transmembrane components commonly found in other members of the family. Structurally, RLIs have an N-terminal Fe-S domain and two nucleotide binding domains which are arranged to form two composite active sites in their interface cleft. RLI is one of the most conserved enzymes between archaea and eukaryotes with a sequence identity more than 48%. The high degree of evolutionary conservation suggests that RLI performs a central role in archaeal and eukaryotic physiology.

Pssm-ID: 213203 [Multi-domain] Cd Length: 255 Bit Score: 59.69 E-value: 3.37e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  34 SVKPGEVVALLGESGSGKSVTMRSLL-RLHPkgTLIEGGMTVDGHDImsLSNRALSDLRGAVVSMVFQEPRLALDPVY-- 110
Cdd:cd03236   22 VPREGQVLGLVGPNGIGKSTALKILAgKLKP--NLGKFDDPPDWDEI--LDEFRGSELQNYFTKLLEGDVKVIVKPQYvd 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 111 --------TVGRQIEETIMRH--EKVSRGLAAERALalfqkvripspERRLSNypheMSGGMLQRAMIAMALACNPKVLL 180
Cdd:cd03236   98 lipkavkgKVGELLKKKDERGklDELVDQLELRHVL-----------DRNIDQ----LSGGELQRVAIAAALARDADFYF 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 523689182 181 ADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMY 232
Cdd:cd03236  163 FDEPSSYLDIKQRLNAARLIRELAED-DNYVLVVEHDLAVLDYLSDYIHCLY 213

rim_protein

TIGR01257

retinal-specific rim ABC transporter; This model describes the photoreceptor protein (rim ...

22-234

3.40e-10

retinal-specific rim ABC transporter; This model describes the photoreceptor protein (rim protein) in eukaryotes. It is the member of ABC transporter superfamily. Rim protein is a membrane glycoprotein which is localized in the photoreceptor outer segment discs. Mutation/s in its genetic loci is implicated in the recessive Stargardt's disease. [Transport and binding proteins, Other]

Pssm-ID: 130324 [Multi-domain] Cd Length: 2272 Bit Score: 61.18 E-value: 3.40e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182    22 GKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLrlhPKGTLIEGGMTVDGHDIMSlsnrALSDLRGavvSMVFQE 101
Cdd:TIGR01257 1949 GTSSPAVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLT---GDTTVTSGDATVAGKSILT----NISDVHQ---NMGYCP 2018

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   102 PRLALDPVYTvGRqieETIMRHEKVsRGLAAERalalFQKVRIPSPERR-LSNYPHEM----SGGMLQRAMIAMALACNP 176
Cdd:TIGR01257 2019 QFDAIDDLLT-GR---EHLYLYARL-RGVPAEE----IEKVANWSIQSLgLSLYADRLagtySGGNKRKLSTAIALIGCP 2089

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 523689182   177 KVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAG 234
Cdd:TIGR01257 2090 PLVLLDEPTTGMDPQARRMLWNTIVSIIRE-GRAVVLTSHSMEECEALCTRLAIMVKG 2146

rim_protein

TIGR01257

retinal-specific rim ABC transporter; This model describes the photoreceptor protein (rim ...

11-240

3.68e-10

Pssm-ID: 130324 [Multi-domain] Cd Length: 2272 Bit Score: 61.18 E-value: 3.68e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182    11 ISNLSVTFRRGGKAvkAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGTlieGGMTVDGHDIMSlsnrALSDL 90
Cdd:TIGR01257  931 VKNLVKIFEPSGRP--AVDRLNITFYENQITAFLGHNGAGKTTTLSILTGLLPPTS---GTVLVGGKDIET----NLDAV 1001

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182    91 RGAvvsmvfqeprLALDPVYTV---GRQIEETIMRHEKVSRGLAAERALALFQKVRIPSPERRLSNYPHEMSGGMLQRAM 167
Cdd:TIGR01257 1002 RQS----------LGMCPQHNIlfhHLTVAEHILFYAQLKGRSWEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLS 1071

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 523689182   168 IAMALACNPKVLLADEPTTALDATVQIQILLLIreLQREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEG 240
Cdd:TIGR01257 1072 VAIAFVGDAKVVVLDEPTSGVDPYSRRSIWDLL--LKYRSGRTIIMSTHHMDEADLLGDRIAIISQGRLYCSG 1142

Rli1

COG1245

Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ...

25-230

4.49e-10

Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ribosomal structure and biogenesis];

Pssm-ID: 440858 [Multi-domain] Cd Length: 592 Bit Score: 60.57 E-value: 4.49e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  25 VKAVNGVSLSVKPG-----EVVALLGESGSGKSVTMRSLL-RLHPKGTLIEGGMTVdghdimSLSNRALS-DLRGAVVSM 97
Cdd:COG1245  348 TKSYGGFSLEVEGGeiregEVLGIVGPNGIGKTTFAKILAgVLKPDEGEVDEDLKI------SYKPQYISpDYDGTVEEF 421

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  98 VFQeprlaldpvyTVGRQIEETIMRHEkVSRGLAAERALalfqkvripspERRLSnyphEMSGGMLQRAMIAMALACNPK 177
Cdd:COG1245  422 LRS----------ANTDDFGSSYYKTE-IIKPLGLEKLL-----------DKNVK----DLSGGELQRVAIAACLSRDAD 475

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 523689182 178 VLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAV 230
Cdd:COG1245  476 LYLLDEPSAHLDVEQRLAVAKAIRRFAENRGKTAMVVDHDIYLIDYISDRLMV 528

ycf16

CHL00131

sulfate ABC transporter protein; Validated

2-240

5.72e-10

sulfate ABC transporter protein; Validated

Pssm-ID: 214372 [Multi-domain] Cd Length: 252 Bit Score: 58.88 E-value: 5.72e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   2 TMQNDAMIDISNLSVTFrrggKAVKAVNGVSLSVKPGEVVALLGESGSGKSvTMRSLLRLHPKGTLIEGGMTVDGHDIMS 81
Cdd:CHL00131   1 MNKNKPILEIKNLHASV----NENEILKGLNLSINKGEIHAIMGPNGSGKS-TLSKVIAGHPAYKILEGDILFKGESILD 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  82 LSNRALSDLRgavVSMVFQEP------------RLALDPVytvgrqieetimrheKVSRGLAAERALALFQKVR-----I 144
Cdd:CHL00131  76 LEPEERAHLG---IFLAFQYPieipgvsnadflRLAYNSK---------------RKFQGLPELDPLEFLEIINeklklV 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 145 PSPERRLSNYPHE-MSGGMLQRAMI-AMALAcNPKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTH-----D 217
Cdd:CHL00131 138 GMDPSFLSRNVNEgFSGGEKKRNEIlQMALL-DSELAILDETDSGLDIDALKIIAEGINKLMTS-ENSIILITHyqrllD 215

                        250       260
                 ....*....|....*....|....
gi 523689182 218 -IgvaaeVADRIAVMYAGRIVEEG 240
Cdd:CHL00131 216 yI-----KPDYVHVMQNGKIIKTG 234

PLN03232

ABC transporter C family member; Provisional

8-238

9.56e-10

ABC transporter C family member; Provisional

Pssm-ID: 215640 [Multi-domain] Cd Length: 1495 Bit Score: 59.99 E-value: 9.56e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182    8 MIDISNLSVTFRRGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLhpkGTLIEGGMTVDGHDIMSLsnrAL 87
Cdd:PLN03232 1234 SIKFEDVHLRYRPGLPPV--LHGLSFFVSPSEKVGVVGRTGAGKSSMLNALFRI---VELEKGRIMIDDCDVAKF---GL 1305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   88 SDLRgAVVSMVFQEP-------RLALDPvytvgrqieetIMRHEKVSRGLAAERalALFQKVRIPSP---ERRLSNYPHE 157
Cdd:PLN03232 1306 TDLR-RVLSIIPQSPvlfsgtvRFNIDP-----------FSEHNDADLWEALER--AHIKDVIDRNPfglDAEVSEGGEN 1371

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  158 MSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREygLSVIFVTHDIGVAAEvADRIAVMYAGRIV 237
Cdd:PLN03232 1372 FSVGQRQLLSLARALLRRSKILVLDEATASVDVRTDSLIQRTIREEFKS--CTMLVIAHRLNTIID-CDKILVLSSGQVL 1448


                  .
gi 523689182  238 E 238
Cdd:PLN03232 1449 E 1449

ABC_RNaseL_inhibitor_domain2

cd03237

The ATP-binding cassette domain 2 of RNase L inhibitor; The ABC ATPase, RNase L inhibitor (RLI) ...

25-230

1.06e-09

The ATP-binding cassette domain 2 of RNase L inhibitor; The ABC ATPase, RNase L inhibitor (RLI), is a key enzyme in ribosomal biogenesis, formation of translation preinitiation complexes, and assembly of HIV capsids. RLI's are not transport proteins and thus cluster with a group of soluble proteins that lack the transmembrane components commonly found in other members of the family. Structurally, RLI's have an N-terminal Fe-S domain and two nucleotide-binding domains which are arranged to form two composite active sites in their interface cleft. RLI is one of the most conserved enzymes between archaea and eukaryotes with a sequence identity of more than 48%. The high degree of evolutionary conservation suggests that RLI performs a central role in archaeal and eukaryotic physiology.

Pssm-ID: 213204 [Multi-domain] Cd Length: 246 Bit Score: 57.80 E-value: 1.06e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  25 VKAVNGVSLSVKPG-----EVVALLGESGSGKSvTMRSLL--RLHPKgtliEGGMTVDGHDIMSLSNRALSDLRGAVVSM 97
Cdd:cd03237    7 KKTLGEFTLEVEGGsisesEVIGILGPNGIGKT-TFIKMLagVLKPD----EGDIEIELDTVSYKPQYIKADYEGTVRDL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  98 VFQE-PRLALDPVYTVgrqieetimrheKVSRGLAAERALalfqkvripspERRLSnyphEMSGGMLQRAMIAMALACNP 176
Cdd:cd03237   82 LSSItKDFYTHPYFKT------------EIAKPLQIEQIL-----------DREVP----ELSGGELQRVAIAACLSKDA 134

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 523689182 177 KVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAV 230
Cdd:cd03237  135 DIYLLDEPSAYLDVEQRLMASKVIRRFAENNEKTAFVVEHDIIMIDYLADRLIV 188

CFTR_protein

TIGR01271

cystic fibrosis transmembrane conductor regulator (CFTR); The model describes the cystis ...

5-218

1.41e-09

cystic fibrosis transmembrane conductor regulator (CFTR); The model describes the cystis fibrosis transmembrane conductor regulator (CFTR) in eukaryotes. The principal role of this protein is chloride ion conductance. The protein is predicted to consist of 12 transmembrane domains. Mutations or lesions in the genetic loci have been linked to the aetiology of asthma, bronchiectasis, chronic obstructive pulmonary disease etc. Disease-causing mutations have been studied by 36Cl efflux assays in vitro cell cultures and electrophysiology, all of which point to the impairment of chloride channel stability and not the biosynthetic processing per se. [Transport and binding proteins, Anions]

Pssm-ID: 273530 [Multi-domain] Cd Length: 1490 Bit Score: 59.15 E-value: 1.41e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182     5 NDAMIDISNLSVTFRRGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKgtliEGGMTVDGHDIMSLSN 84
Cdd:TIGR01271 1214 SGGQMDVQGLTAKYTEAGRAV--LQDLSFSVEGGQRVGLLGRTGSGKSTLLSALLRLLST----EGEIQIDGVSWNSVTL 1287

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182    85 RALSDLRGAVVSMVF---QEPRLALDPvytVGRQIEETIMrheKVSRGLAAERALALFqkvripsPER---RLSNYPHEM 158
Cdd:TIGR01271 1288 QTWRKAFGVIPQKVFifsGTFRKNLDP---YEQWSDEEIW---KVAEEVGLKSVIEQF-------PDKldfVLVDGGYVL 1354

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 523689182   159 SGGMLQRAMIAMALACNPKVLLADEPTTALDAtVQIQILLliRELQREYG-LSVIFVTHDI 218
Cdd:TIGR01271 1355 SNGHKQLMCLARSILSKAKILLLDEPSAHLDP-VTLQIIR--KTLKQSFSnCTVILSEHRV 1412

PLN03130

ABC transporter C family member; Provisional

30-255

1.95e-09

ABC transporter C family member; Provisional

Pssm-ID: 215595 [Multi-domain] Cd Length: 1622 Bit Score: 58.98 E-value: 1.95e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   30 GVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHpkgTLIEGGMTVDGHDIMSLsnrALSDLRgAVVSMVFQEP------- 102
Cdd:PLN03130 1257 GLSFEISPSEKVGIVGRTGAGKSSMLNALFRIV---ELERGRILIDGCDISKF---GLMDLR-KVLGIIPQAPvlfsgtv 1329

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  103 RLALDPV---------YTVGR-QIEETIMRHekvSRGLAAEralalfqkvripsperrLSNYPHEMSGGMLQRAMIAMAL 172
Cdd:PLN03130 1330 RFNLDPFnehndadlwESLERaHLKDVIRRN---SLGLDAE-----------------VSEAGENFSVGQRQLLSLARAL 1389

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  173 ACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIfvTHDIGVAAEvADRIAVMYAGRIVEEGLVGDIIRNPRHP 252
Cdd:PLN03130 1390 LRRSKILVLDEATAAVDVRTDALIQKTIREEFKSCTMLII--AHRLNTIID-CDRILVLDAGRVVEFDTPENLLSNEGSA 1466


                  ...
gi 523689182  253 YTK 255
Cdd:PLN03130 1467 FSK 1469

PRK03695

vitamin B12-transporter ATPase; Provisional

31-240

3.40e-09

vitamin B12-transporter ATPase; Provisional

Pssm-ID: 235150 [Multi-domain] Cd Length: 248 Bit Score: 56.48 E-value: 3.40e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  31 VSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKgtliEGGMTVDGHDIMSLSNRALSDLRGAVVSmvfQEPRLALDPVY 110
Cdd:PRK03695  15 LSAEVRAGEILHLVGPNGAGKSTLLARMAGLLPG----SGSIQFAGQPLEAWSAAELARHRAYLSQ---QQTPPFAMPVF 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 111 tvgrqieETIMRHEKVSRGLAAERALA--LFQKVRIpspERRLSNYPHEMSGGMLQRAMIAMAL-----ACNP--KVLLA 181
Cdd:PRK03695  88 -------QYLTLHQPDKTRTEAVASALneVAEALGL---DDKLGRSVNQLSGGEWQRVRLAAVVlqvwpDINPagQLLLL 157

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 523689182 182 DEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEG 240
Cdd:PRK03695 158 DEPMNSLDVAQQAALDRLLSELCQQ-GIAVVMSSHDLNHTLRHADRVWLLKQGKLLASG 215

Rli1

COG1245

Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ...

28-250

4.15e-09

Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ribosomal structure and biogenesis];

Pssm-ID: 440858 [Multi-domain] Cd Length: 592 Bit Score: 57.49 E-value: 4.15e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  28 VNGVSL----SVKPGEVVALLGESGSGKSVTMRSLlrlhpKGTLI----EGGMTVDGHDImslsnraLSDLRGAVVSMVF 99
Cdd:COG1245   85 ENGFRLyglpVPKKGKVTGILGPNGIGKSTALKIL-----SGELKpnlgDYDEEPSWDEV-------LKRFRGTELQDYF 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 100 Q-----EPRLALDP--VYTVGRQIEETIMR-HEKV-SRGLAAEralaLFQKVRI-PSPERRLSnyphEMSGGMLQRAMIA 169
Cdd:COG1245  153 KklangEIKVAHKPqyVDLIPKVFKGTVRElLEKVdERGKLDE----LAEKLGLeNILDRDIS----ELSGGELQRVAIA 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 170 MALACNPKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAAEVADRIAVMYAgrivEEGLVGdIIRNP 249
Cdd:COG1245  225 AALLRDADFYFFDEPSSYLDIYQRLNVARLIRELAEE-GKYVLVVEHDLAILDYLADYVHILYG----EPGVYG-VVSKP 298


                 .
gi 523689182 250 R 250
Cdd:COG1245  299 K 299

MRP_assoc_pro

TIGR00957

multi drug resistance-associated protein (MRP); This model describes multi drug ...

9-240

6.64e-09

multi drug resistance-associated protein (MRP); This model describes multi drug resistance-associated protein (MRP) in eukaryotes. The multidrug resistance-associated protein is an integral membrane protein that causes multidrug resistance when overexpressed in mammalian cells. It belongs to ABC transporter superfamily. The protein topology and function was experimentally demonstrated by epitope tagging and immunofluorescence. Insertion of tags in the critical regions associated with drug efflux, abrogated its function. The C-terminal domain seem to highly conserved. [Transport and binding proteins, Other]

Pssm-ID: 188098 [Multi-domain] Cd Length: 1522 Bit Score: 57.26 E-value: 6.64e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182     9 IDISNLSVTFRRGGKAvkAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKgtlIEGGMTVDGHdimslsnrals 88
Cdd:TIGR00957  637 ITVHNATFTWARDLPP--TLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDK---VEGHVHMKGS----------- 700

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182    89 dlrgavVSMVFQEPRLALDPVYT---VGRQIEETIMRhekvsrglAAERALALFQKVRI-PSPER-RLSNYPHEMSGGML 163
Cdd:TIGR00957  701 ------VAYVPQQAWIQNDSLREnilFGKALNEKYYQ--------QVLEACALLPDLEIlPSGDRtEIGEKGVNLSGGQK 766

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 523689182   164 QRAMIAMALACNPKVLLADEPTTALDATVQIQIL-LLIRELQREYGLSVIFVTHDIGVAAEVaDRIAVMYAGRIVEEG 240
Cdd:TIGR00957  767 QRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFeHVIGPEGVLKNKTRILVTHGISYLPQV-DVIIVMSGGKISEMG 843

ABCC_CFTR2

cd03289

ATP-binding cassette domain 2 of CFTR,subfamily C; The cystic fibrosis transmembrane regulator ...

9-218

8.33e-09

ATP-binding cassette domain 2 of CFTR,subfamily C; The cystic fibrosis transmembrane regulator (CFTR), the product of the gene mutated in patients with cystic fibrosis, has adapted the ABC transporter structural motif to form a tightly regulated anion channel at the apical surface of many epithelia. Use of the term assembly of a functional ion channel implies the coming together of subunits or at least smaller not-yet functional components of the active whole. In fact, on the basis of current knowledge only the CFTR polypeptide itself is required to form an ATP- and protein kinase A-dependent low-conductance chloride channel of the type present in the apical membrane of many epithelial cells. CFTR displays the typical organization (IM-ABC)2 and carries a characteristic hydrophilic R-domain that separates IM1-ABC1 from IM2-ABC2.

Pssm-ID: 213256 [Multi-domain] Cd Length: 275 Bit Score: 55.63 E-value: 8.33e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTFRRGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLhpkgTLIEGGMTVDGHDIMSLSNRALS 88
Cdd:cd03289    3 MTVKDLTAKYTEGGNAV--LENISFSISPGQRVGLLGRTGSGKSTLLSAFLRL----LNTEGDIQIDGVSWNSVPLQKWR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  89 DLRGAVVSMVF---QEPRLALDPvytVGRQIEETIMRhekvsrgLAAERALALFQKVRIPSPERRLSNYPHEMSGGMLQR 165
Cdd:cd03289   77 KAFGVIPQKVFifsGTFRKNLDP---YGKWSDEEIWK-------VAEEVGLKSVIEQFPGQLDFVLVDGGCVLSHGHKQL 146

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 523689182 166 AMIAMALACNPKVLLADEPTTALDAtVQIQILLliRELQREY-GLSVIFVTHDI 218
Cdd:cd03289  147 MCLARSVLSKAKILLLDEPSAHLDP-ITYQVIR--KTLKQAFaDCTVILSEHRI 197

sufC

PRK09580

cysteine desulfurase ATPase component; Reviewed

8-240

8.41e-09

cysteine desulfurase ATPase component; Reviewed

Pssm-ID: 181965 [Multi-domain] Cd Length: 248 Bit Score: 55.18 E-value: 8.41e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSVTFRrgGKAVkaVNGVSLSVKPGEVVALLGESGSGKSvTMRSLLRLHPKGTLIEGGMTVDGHDIMSLSNral 87
Cdd:PRK09580   1 MLSIKDLHVSVE--DKAI--LRGLNLEVRPGEVHAIMGPNGSGKS-TLSATLAGREDYEVTGGTVEFKGKDLLELSP--- 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  88 SDLRGAVVSMVFQEprlaldPVYTVGRQIEETIMRHEKVSRGLAAERALALFQKVRIPSPERRLSNYPHEM--------- 158
Cdd:PRK09580  73 EDRAGEGIFMAFQY------PVEIPGVSNQFFLQTALNAVRSYRGQEPLDRFDFQDLMEEKIALLKMPEDLltrsvnvgf 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 159 SGGMLQRAMIAMALACNPKVLLADEPTTALDatvqIQILLLIRE---LQREYGLSVIFVTHDIGVAAEVA-DRIAVMYAG 234
Cdd:PRK09580 147 SGGEKKRNDILQMAVLEPELCILDESDSGLD----IDALKIVADgvnSLRDGKRSFIIVTHYQRILDYIKpDYVHVLYQG 222


                 ....*.
gi 523689182 235 RIVEEG 240
Cdd:PRK09580 223 RIVKSG 228

PRK13409

ribosome biogenesis/translation initiation ATPase RLI;

9-232

1.11e-08

ribosome biogenesis/translation initiation ATPase RLI;

Pssm-ID: 184037 [Multi-domain] Cd Length: 590 Bit Score: 56.36 E-value: 1.11e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNL------SVTFRRGgkavkaVNGVSL----SVKPGEVVALLGESGSGKSVTMRSLlrlhpKGTLI------EGGM 72
Cdd:PRK13409  66 ISIVNLpeeleeEPVHRYG------VNGFKLyglpIPKEGKVTGILGPNGIGKTTAVKIL-----SGELIpnlgdyEEEP 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  73 TVDghdimslsnRALSDLRGAVVSMVFQ-----EPRLALDPVY----------TVG---RQIEETIMRHEKVSRgLAAER 134
Cdd:PRK13409 135 SWD---------EVLKRFRGTELQNYFKklyngEIKVVHKPQYvdlipkvfkgKVRellKKVDERGKLDEVVER-LGLEN 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 135 ALalfqkvripspERRLSNypheMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQReyGLSVIFV 214
Cdd:PRK13409 205 IL-----------DRDISE----LSGGELQRVAIAAALLRDADFYFFDEPTSYLDIRQRLNVARLIRELAE--GKYVLVV 267

                        250
                 ....*....|....*...
gi 523689182 215 THDIGVAAEVADRIAVMY 232
Cdd:PRK13409 268 EHDLAVLDYLADNVHIAY 285

PRK13539

cytochrome c biogenesis protein CcmA; Provisional

8-216

1.35e-08

cytochrome c biogenesis protein CcmA; Provisional

Pssm-ID: 237421 [Multi-domain] Cd Length: 207 Bit Score: 54.11 E-value: 1.35e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSVtfRRGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPkgtLIEGGMTVDGHDImslsnrAL 87
Cdd:PRK13539   2 MLEGEDLAC--VRGGRVL--FSGLSFTLAAGEALVLTGPNGSGKTTLLRLIAGLLP---PAAGTIKLDGGDI------DD 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  88 SDLRGAvvsMVFQEPRLALDPVYTVGRQIEetIMRHEKVSRGLAAERALALFQkvripsperrLSNYPH----EMSGGML 163
Cdd:PRK13539  69 PDVAEA---CHYLGHRNAMKPALTVAENLE--FWAAFLGGEELDIAAALEAVG----------LAPLAHlpfgYLSAGQK 133

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 523689182 164 QRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRElQREYGLSVIFVTH 216
Cdd:PRK13539 134 RRVALARLLVSNRPIWILDEPTAALDAAAVALFAELIRA-HLAQGGIVIAATH 185

ABC_RNaseL_inhibitor

cd03222

ATP-binding cassette domain of RNase L inhibitor; The ABC ATPase RNase L inhibitor (RLI) is a ...

157-232

1.66e-08

ATP-binding cassette domain of RNase L inhibitor; The ABC ATPase RNase L inhibitor (RLI) is a key enzyme in ribosomal biogenesis, formation of translation preinitiation complexes, and assembly of HIV capsids. RLI's are not transport proteins, and thus cluster with a group of soluble proteins that lack the transmembrane components commonly found in other members of the family. Structurally, RLI's have an N-terminal Fe-S domain and two nucleotide-binding domains, which are arranged to form two composite active sites in their interface cleft. RLI is one of the most conserved enzymes between archaea and eukaryotes with a sequence identity more than 48%. The high degree of evolutionary conservation suggests that RLI performs a central role in archaeal and eukaryotic physiology.

Pssm-ID: 213189 [Multi-domain] Cd Length: 177 Bit Score: 53.34 E-value: 1.66e-08

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 523689182 157 EMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAVMY 232
Cdd:cd03222   71 DLSGGELQRVAIAAALLRNATFYLFDEPSAYLDIEQRLNAARAIRRLSEEGKKTALVVEHDLAVLDYLSDRIHVFE 146

3a01205

TIGR00956

Pleiotropic Drug Resistance (PDR) Family protein; [Transport and binding proteins, Other]

25-241

2.78e-08

Pleiotropic Drug Resistance (PDR) Family protein; [Transport and binding proteins, Other]

Pssm-ID: 273362 [Multi-domain] Cd Length: 1394 Bit Score: 55.11 E-value: 2.78e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182    25 VKAVNGVslsVKPGEVVALLGESGSGKSVTMRSLL-RLHPKGTLIEGGMTVDGHDIMSLSNRalsdLRGAVVSMVFQEPR 103
Cdd:TIGR00956   77 LKPMDGL---IKPGELTVVLGRPGSGCSTLLKTIAsNTDGFHIGVEGVITYDGITPEEIKKH----YRGDVVYNAETDVH 149

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   104 LaldPVYTVGRQIEETIM------RHEKVSRGLAAERALALFQKVRIPSPERRlSNYPHEM----SGGMLQRAMIAMALA 173
Cdd:TIGR00956  150 F---PHLTVGETLDFAARcktpqnRPDGVSREEYAKHIADVYMATYGLSHTRN-TKVGNDFvrgvSGGERKRVSIAEASL 225

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 523689182   174 CNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSViFVThdIGVAAEVA----DRIAVMYAGRIVEEGL 241
Cdd:TIGR00956  226 GGAKIQCWDNATRGLDSATALEFIRALKTSANILDTTP-LVA--IYQCSQDAyelfDKVIVLYEGYQIYFGP 294

GguA

NF040905

sugar ABC transporter ATP-binding protein;

26-239

4.73e-08

sugar ABC transporter ATP-binding protein;

Pssm-ID: 468840 [Multi-domain] Cd Length: 500 Bit Score: 54.03 E-value: 4.73e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  26 KAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRlHPKGTLIEGGMTVDGHDImslsnrALSDLRGAV------VSmvf 99
Cdd:NF040905 274 KVVDDVSLNVRRGEIVGIAGLMGAGRTELAMSVFG-RSYGRNISGTVFKDGKEV------DVSTVSDAIdaglayVT--- 343

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 100 qEPR--LALDPVYTVGRQIeeTIMRHEKVSRG----LAAERALA--LFQKVRI--PSPERRLSNypheMSGGMLQRAMIA 169
Cdd:NF040905 344 -EDRkgYGLNLIDDIKRNI--TLANLGKVSRRgvidENEEIKVAeeYRKKMNIktPSVFQKVGN----LSGGNQQKVVLS 416

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 523689182 170 MALACNPKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHD----IGvaaeVADRIAVMYAGRIVEE 239
Cdd:NF040905 417 KWLFTDPDVLILDEPTRGIDVGAKYEIYTIINELAAE-GKGVIVISSElpelLG----MCDRIYVMNEGRITGE 485

ABCC_MRP_domain1

cd03250

ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C; This ...

9-235

9.31e-08

ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C; This subfamily is also known as MRP (multidrug resistance-associated protein). Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional membrane-spanning domains is not clear. The MRP was found in the multidrug-resisting lung cancer cell in which p-glycoprotein was not overexpressed. MRP exports glutathione by drug stimulation, as well as, certain substrates in conjugated forms with anions, such as glutathione, glucuronate, and sulfate.

Pssm-ID: 213217 [Multi-domain] Cd Length: 204 Bit Score: 51.70 E-value: 9.31e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTF-RRGGKAVKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLrlhpkG--TLIEGGMTVDGHdimslsnr 85
Cdd:cd03250    1 ISVEDASFTWdSGEQETSFTLKDINLEVPKGELVAIVGPVGSGKSSLLSALL-----GelEKLSGSVSVPGS-------- 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  86 alsdlrgavVSMVFQEPRLALDpvyTV------GRQIEEtiMRHEKVSRGLAAERALALFqkvripsP--------ERRL 151
Cdd:cd03250   68 ---------IAYVSQEPWIQNG---TIrenilfGKPFDE--ERYEKVIKACALEPDLEIL-------PdgdlteigEKGI 126

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 152 SnypheMSGGmlQRAMIAMALAC--NPKVLLADEPTTALDATVQIQIL--LLIRELQReyGLSVIFVTHDIGVAAEvADR 227
Cdd:cd03250  127 N-----LSGG--QKQRISLARAVysDADIYLLDDPLSAVDAHVGRHIFenCILGLLLN--NKTRILVTHQLQLLPH-ADQ 196


                 ....*...
gi 523689182 228 IAVMYAGR 235
Cdd:cd03250  197 IVVLDNGR 204

PRK13409

ribosome biogenesis/translation initiation ATPase RLI;

25-230

1.19e-07

ribosome biogenesis/translation initiation ATPase RLI;

Pssm-ID: 184037 [Multi-domain] Cd Length: 590 Bit Score: 52.89 E-value: 1.19e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  25 VKAVNGVSLSVKPG-----EVVALLGESGSGKSVTMRsllrlhpkgtLIEGGMTVDGHDimslsnralsdlrgavvsmVF 99
Cdd:PRK13409 347 TKKLGDFSLEVEGGeiyegEVIGIVGPNGIGKTTFAK----------LLAGVLKPDEGE-------------------VD 397

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 100 QEPRLALDPVY-------TVG---RQIEETIM----RHEkVSRGLAAERALalfqkvripspERRLSnyphEMSGGMLQR 165
Cdd:PRK13409 398 PELKISYKPQYikpdydgTVEdllRSITDDLGssyyKSE-IIKPLQLERLL-----------DKNVK----DLSGGELQR 461

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 523689182 166 AMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTHDIGVAAEVADRIAV 230
Cdd:PRK13409 462 VAIAACLSRDADLYLLDEPSAHLDVEQRLAVAKAIRRIAEEREATALVVDHDIYMIDYISDRLMV 526

PTZ00265

multidrug resistance protein (mdr1); Provisional

4-230

1.39e-07

multidrug resistance protein (mdr1); Provisional

Pssm-ID: 240339 [Multi-domain] Cd Length: 1466 Bit Score: 53.11 E-value: 1.39e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182    4 QNDAMIDISNLSVTFRRGGKA-VKAVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLH-------------------- 62
Cdd:PTZ00265 1159 KNDIKGKIEIMDVNFRYISRPnVPIYKDLTFSCDSKKTTAIVGETGSGKSTVMSLLMRFYdlkndhhivfknehtndmtn 1238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   63 -----------------------------PKGTLIE--GGMTVDGHDIMSLSnraLSDLRGaVVSMVFQEPRLALDPVYT 111
Cdd:PTZ00265 1239 eqdyqgdeeqnvgmknvnefsltkeggsgEDSTVFKnsGKILLDGVDICDYN---LKDLRN-LFSIVSQEPMLFNMSIYE 1314

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  112 VGRQIEETIMRhEKVSRglaAERALALFQKVR-IPSP-ERRLSNYPHEMSGGMLQRAMIAMALACNPKVLLADEPTTALD 189
Cdd:PTZ00265 1315 NIKFGKEDATR-EDVKR---ACKFAAIDEFIEsLPNKyDTNVGPYGKSLSGGQKQRIAIARALLREPKILLLDEATSSLD 1390

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 523689182  190 ATVQIQILLLIRELQREYGLSVIFVTHDIGvAAEVADRIAV 230
Cdd:PTZ00265 1391 SNSEKLIEKTIVDIKDKADKTIITIAHRIA-SIKRSDKIVV 1430

ABC_ABC_ChvD

TIGR03719

ATP-binding cassette protein, ChvD family; Members of this protein family have two copies of ...

17-217

1.53e-07

ATP-binding cassette protein, ChvD family; Members of this protein family have two copies of the ABC transporter ATP-binding cassette, but are found outside the common ABC transporter operon structure that features integral membrane permease proteins and substrate-binding proteins encoded next to the ATP-binding cassette (ABC domain) protein. The member protein ChvD from Agrobacterium tumefaciens was identified as both a candidate to interact with VirB8, based on yeast two-hybrid analysis, and as an apparent regulator of VirG. The general function of this protein family is unknown.

Pssm-ID: 274744 [Multi-domain] Cd Length: 552 Bit Score: 52.63 E-value: 1.53e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   17 TFRRGGKAV----KAVNGVSLSVKPGEVVALLGESGSGKSvtmrSLLRlhpkgtlIEGGMTVDghdimsLSNRALSDLrG 92
Cdd:TIGR03719   6 TMNRVSKVVppkkEILKDISLSFFPGAKIGVLGLNGAGKS----TLLR-------IMAGVDKD------FNGEARPQP-G 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   93 AVVSMVFQEPRLalDPVYTVGRQIEE-------TIMRHEKVSRGLAAERAL--ALFQK---------------------- 141
Cdd:TIGR03719  68 IKVGYLPQEPQL--DPTKTVRENVEEgvaeikdALDRFNEISAKYAEPDADfdKLAAEqaelqeiidaadawdldsqlei 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  142 ----VRIPSPERRLSNypheMSGGMLQRAMIAMALACNPKVLLADEPTTALDATvqiQILLLIRELQrEYGLSVIFVTHD 217
Cdd:TIGR03719 146 amdaLRCPPWDADVTK----LSGGERRRVALCRLLLSKPDMLLLDEPTNHLDAE---SVAWLERHLQ-EYPGTVVAVTHD 217

PLN03211

ABC transporter G-25; Provisional

28-240

1.64e-07

ABC transporter G-25; Provisional

Pssm-ID: 215634 [Multi-domain] Cd Length: 659 Bit Score: 52.57 E-value: 1.64e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  28 VNGVSLSVKPGEVVALLGESGSGKSVTMRSLL-RLHpkGTLIEGGMTVDGHDIMSLSNRALsdlrGAVVSMVFQEPRLAL 106
Cdd:PLN03211  84 LNGVTGMASPGEILAVLGPSGSGKSTLLNALAgRIQ--GNNFTGTILANNRKPTKQILKRT----GFVTQDDILYPHLTV 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 107 DP--VYTVGRQIEETIMRHEK--VSRGLAAERALALFQKVRIPSperrlsNYPHEMSGGMLQRAMIAMALACNPKVLLAD 182
Cdd:PLN03211 158 REtlVFCSLLRLPKSLTKQEKilVAESVISELGLTKCENTIIGN------SFIRGISGGERKRVSIAHEMLINPSLLILD 231

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 523689182 183 EPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGVAA-EVADRIAVMYAGRIVEEG 240
Cdd:PLN03211 232 EPTSGLDATAAYRLVLTLGSLAQK-GKTIVTSMHQPSSRVyQMFDSVLVLSEGRCLFFG 289

ABCD_peroxisomal_ALDP

cd03223

ATP-binding cassette domain of peroxisomal transporter, subfamily D; Peroxisomal ATP-binding ...

9-216

1.90e-07

ATP-binding cassette domain of peroxisomal transporter, subfamily D; Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed during fatty acid beta-oxidation. To communicate with the cytoplasm and mitochondria, peroxisomes need dedicated proteins to transport such hydrophilic molecules across their membranes. X-linked adrenoleukodystrophy (X-ALD) is caused by mutations in the ALD gene, which encodes ALDP (adrenoleukodystrophy protein ), a peroxisomal integral membrane protein that is a member of the ATP-binding cassette (ABC) transporter protein family. The disease is characterized by a striking and unpredictable variation in phenotypic expression. Phenotypes include the rapidly progressive childhood cerebral form (CCALD), the milder adult form, adrenomyeloneuropathy (AMN), and variants without neurologic involvement (i.e. asymptomatic).

Pssm-ID: 213190 [Multi-domain] Cd Length: 166 Bit Score: 50.23 E-value: 1.90e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTFRRGGKAVKAVngvSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGTlieggmtvdGHDIMSLSNRALs 88
Cdd:cd03223    1 IELENLSLATPDGRVLLKDL---SFEIKPGDRLLITGPSGTGKSSLFRALAGLWPWGS---------GRIGMPEGEDLL- 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  89 dlrgavvsMVFQEPRLaldPVYTVGRQIeetimrhekvsrglaaeralalfqkvripsperrlsNYP--HEMSGGMLQRA 166
Cdd:cd03223   68 --------FLPQRPYL---PLGTLREQL------------------------------------IYPwdDVLSGGEQQRL 100

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 523689182 167 MIAMALACNPKVLLADEPTTALDATVQIQILLLIRELqreyGLSVIFVTH 216
Cdd:cd03223  101 AFARLLLHKPKFVFLDEATSALDEESEDRLYQLLKEL----GITVISVGH 146

AAA

smart00382

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...

37-230

3.99e-07

Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 48.91 E-value: 3.99e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182    37 PGEVVALLGESGSGKSVTMRSLLRLhpkgtlieggmtvdghdimslsnraLSDLRGAVVsmvfqepRLALDPVYTVGRQI 116
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARE-------------------------LGPPGGGVI-------YIDGEDILEEVLDQ 48

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   117 EETIMRHEKVSRGlaaeralalfqkvripsperrlsnyphemSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQI 196
Cdd:smart00382  49 LLLIIVGGKKASG-----------------------------SGELRLRLALALARKLKPDVLILDEITSLLDAEQEALL 99

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 523689182   197 LLLIR-----ELQREYGLSVIFVTHDIGVAAEVADRIAV 230
Cdd:smart00382 100 LLLEElrlllLLKSEKNLTVILTTNDEKDLGPALLRRRF 138

3a01205

TIGR00956

Pleiotropic Drug Resistance (PDR) Family protein; [Transport and binding proteins, Other]

29-203

1.04e-06

Pleiotropic Drug Resistance (PDR) Family protein; [Transport and binding proteins, Other]

Pssm-ID: 273362 [Multi-domain] Cd Length: 1394 Bit Score: 50.49 E-value: 1.04e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182    29 NGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGTLIEGGMTVDGHDIMSLSNRALsdlrGAVvsmvfQEPRLALdP 108
Cdd:TIGR00956  780 NNVDGWVKPGTLTALMGASGAGKTTLLNVLAERVTTGVITGGDRLVNGRPLDSSFQRSI----GYV-----QQQDLHL-P 849

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   109 VYTVG---------RQ-----IEETIMRHEKVSRGLAAER-ALALfqkVRIP----SPERRlsnyphemsggmlQRAMIA 169
Cdd:TIGR00956  850 TSTVReslrfsaylRQpksvsKSEKMEYVEEVIKLLEMESyADAV---VGVPgeglNVEQR-------------KRLTIG 913

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 523689182   170 MALACNPKVLL-ADEPTTALDATVQIQILLLIREL 203
Cdd:TIGR00956  914 VELVAKPKLLLfLDEPTSGLDSQTAWSICKLMRKL 948

PTZ00243

ABC transporter; Provisional

28-249

4.80e-06

ABC transporter; Provisional

Pssm-ID: 240327 [Multi-domain] Cd Length: 1560 Bit Score: 48.24 E-value: 4.80e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   28 VNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRlhpkgtLIE---GGMTVDGHDIMSLSNRALSDLrgavVSMVFQEP-- 102
Cdd:PTZ00243 1326 LRGVSFRIAPREKVGIVGRTGSGKSTLLLTFMR------MVEvcgGEIRVNGREIGAYGLRELRRQ----FSMIPQDPvl 1395

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  103 -----RLALDPVYT-----VGRQIEETIMRhEKVsrglAAERAlalfqkvRIPSpeRRL---SNYphemSGGmlQRAMIA 169
Cdd:PTZ00243 1396 fdgtvRQNVDPFLEassaeVWAALELVGLR-ERV----ASESE-------GIDS--RVLeggSNY----SVG--QRQLMC 1455

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  170 MALACNPK---VLLADEPTTALDATVQIQILLLIRELQREYglSVIFVTHDIGVAAEVaDRIAVMYAGRIVEEGLVGDII 246
Cdd:PTZ00243 1456 MARALLKKgsgFILMDEATANIDPALDRQIQATVMSAFSAY--TVITIAHRLHTVAQY-DKIIVMDHGAVAEMGSPRELV 1532


                  ...
gi 523689182  247 RNP 249
Cdd:PTZ00243 1533 MNR 1535

PRK10982

galactose/methyl galaxtoside transporter ATP-binding protein; Provisional

141-238

5.12e-06

galactose/methyl galaxtoside transporter ATP-binding protein; Provisional

Pssm-ID: 182880 [Multi-domain] Cd Length: 491 Bit Score: 47.80 E-value: 5.12e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 141 KVRIPSPERRLSNypheMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGV 220
Cdd:PRK10982 379 RVKTPGHRTQIGS----LSGGNQQKVIIGRWLLTQPEILMLDEPTRGIDVGAKFEIYQLIAELAKK-DKGIIIISSEMPE 453

                         90       100
                 ....*....|....*....|.
gi 523689182 221 AAEVADRIAVMYAGR---IVE 238
Cdd:PRK10982 454 LLGITDRILVMSNGLvagIVD 474

ABC2_perm_RbbA

NF033858

ribosome-associated ATPase/putative transporter RbbA;

27-236

8.56e-06

ribosome-associated ATPase/putative transporter RbbA;

Pssm-ID: 468210 [Multi-domain] Cd Length: 907 Bit Score: 47.43 E-value: 8.56e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  27 AVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGtliEG-----GMTVDGHDI--------MSLSNRALSDLrga 93
Cdd:NF033858 281 AVDHVSFRIRRGEIFGFLGSNGCGKSTTMKMLTGLLPAS---EGeawlfGQPVDAGDIatrrrvgyMSQAFSLYGEL--- 354

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  94 vvsmvfqeprlaldpvyTVgRQieeTIMRHEKVSRgLAAERAlalfqKVRIPSPERR--LSNYPHEMSG----GMLQRAM 167
Cdd:NF033858 355 -----------------TV-RQ---NLELHARLFH-LPAAEI-----AARVAEMLERfdLADVADALPDslplGIRQRLS 407

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 523689182 168 IAMALACNPKVLLADEPTT-----ALDATVQiqilLLIrELQREYGLSvIFV-THDIGvAAEVADRIAVMYAGRI 236
Cdd:NF033858 408 LAVAVIHKPELLILDEPTSgvdpvARDMFWR----LLI-ELSREDGVT-IFIsTHFMN-EAERCDRISLMHAGRV 475

PLN03130

ABC transporter C family member; Provisional

31-248

8.56e-06

ABC transporter C family member; Provisional

Pssm-ID: 215595 [Multi-domain] Cd Length: 1622 Bit Score: 47.43 E-value: 8.56e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   31 VSLSVKPGEVVALLGESGSGKSvtmrSLLrlhpKGTLIEGGMTVDGHDImslsnralsdLRGAV-----VSMVFQEprla 105
Cdd:PLN03130  636 INLDVPVGSLVAIVGSTGEGKT----SLI----SAMLGELPPRSDASVV----------IRGTVayvpqVSWIFNA---- 693

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  106 ldpvyTVGRQI----EETIMRHEKVSRGLAAERALALFQKVRIPSPERRLSNypheMSGGMLQRAMIAMALACNPKVLLA 181
Cdd:PLN03130  694 -----TVRDNIlfgsPFDPERYERAIDVTALQHDLDLLPGGDLTEIGERGVN----ISGGQKQRVSMARAVYSNSDVYIF 764

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 523689182  182 DEPTTALDATVQIQIL--LLIRELQREyglSVIFVTHDIGVAAEVaDRIAVMYAGRIVEEGLVGDIIRN 248
Cdd:PLN03130  765 DDPLSALDAHVGRQVFdkCIKDELRGK---TRVLVTNQLHFLSQV-DRIILVHEGMIKEEGTYEELSNN 829

PRK10636

putative ABC transporter ATP-binding protein; Provisional

8-228

1.13e-05

putative ABC transporter ATP-binding protein; Provisional

Pssm-ID: 236729 [Multi-domain] Cd Length: 638 Bit Score: 46.70 E-value: 1.13e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   8 MIDISNLSVtfRRGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSvTMRSLLRlhpkgtlieGGMTVDGHDIMSLSNRAL 87
Cdd:PRK10636   1 MIVFSSLQI--RRGVRVL--LDNATATINPGQKVGLVGKNGCGKS-TLLALLK---------NEISADGGSYTFPGNWQL 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  88 SdlrgavvsMVFQE-PRL---ALDpvYTVG-----RQIEETIMRHEKVSRGLA----------------AERALAL---- 138
Cdd:PRK10636  67 A--------WVNQEtPALpqpALE--YVIDgdreyRQLEAQLHDANERNDGHAiatihgkldaidawtiRSRAASLlhgl 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 139 -FQKVRIPSPERrlsnyphEMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVqiqILLLIRELqREYGLSVIFVTHD 217
Cdd:PRK10636 137 gFSNEQLERPVS-------DFSGGWRMRLNLAQALICRSDLLLLDEPTNHLDLDA---VIWLEKWL-KSYQGTLILISHD 205

                        250
                 ....*....|.
gi 523689182 218 IGVAAEVADRI 228
Cdd:PRK10636 206 RDFLDPIVDKI 216

MRP_assoc_pro

TIGR00957

multi drug resistance-associated protein (MRP); This model describes multi drug ...

9-246

1.32e-05

Pssm-ID: 188098 [Multi-domain] Cd Length: 1522 Bit Score: 46.86 E-value: 1.32e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182     9 IDISNLSVTFRRGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGtliEGGMTVDGHDIMSLsnrALS 88
Cdd:TIGR00957 1285 VEFRNYCLRYREDLDLV--LRHINVTIHGGEKVGIVGRTGAGKSSLTLGLFRINESA---EGEIIIDGLNIAKI---GLH 1356

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182    89 DLRGAvVSMVFQEP-------RLALDPvytVGRQIEETIMrhekvsrgLAAERA-LALFQKVRIPSPERRLSNYPHEMSG 160
Cdd:TIGR00957 1357 DLRFK-ITIIPQDPvlfsgslRMNLDP---FSQYSDEEVW--------WALELAhLKTFVSALPDKLDHECAEGGENLSV 1424

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   161 GMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRElQREyGLSVIFVTHDIGVAAEVAdRIAVMYAGRIVEEG 240
Cdd:TIGR00957 1425 GQRQLVCLARALLRKTKILVLDEATAAVDLETDNLIQSTIRT-QFE-DCTVLTIAHRLNTIMDYT-RVIVLDKGEVAEFG 1501


                   ....*.
gi 523689182   241 LVGDII 246
Cdd:TIGR00957 1502 APSNLL 1507

ABC_UvrA

cd03238

ATP-binding cassette domain of the excision repair protein UvrA; Nucleotide excision repair in ...

158-240

2.43e-05

ATP-binding cassette domain of the excision repair protein UvrA; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep ATP-dependent reaction that requires the UvrA, UvrB, and UvrC proteins. Both UvrA and UvrB are ATPases, with UvrA having two ATP binding sites, which have the characteristic signature of the family of ABC proteins, and UvrB having one ATP binding site that is structurally related to that of helicases.

Pssm-ID: 213205 [Multi-domain] Cd Length: 176 Bit Score: 44.24 E-value: 2.43e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 158 MSGGMLQRAMIAMALACNPK--VLLADEPTTALDATVQIQILLLIRELqREYGLSVIFVTHDIGVaAEVADRIAVM---- 231
Cdd:cd03238   88 LSGGELQRVKLASELFSEPPgtLFILDEPSTGLHQQDINQLLEVIKGL-IDLGNTVILIEHNLDV-LSSADWIIDFgpgs 165

                         90
                 ....*....|.
gi 523689182 232 --YAGRIVEEG 240
Cdd:cd03238  166 gkSGGKVVFSG 176

PLN03232

ABC transporter C family member; Provisional

31-248

2.69e-05

ABC transporter C family member; Provisional

Pssm-ID: 215640 [Multi-domain] Cd Length: 1495 Bit Score: 46.12 E-value: 2.69e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   31 VSLSVKPGEVVALLGESGSGKSVTMRSLLrlhpkGTLieggmtvdghdimSLSNRALSDLRGAV-----VSMVFQEprlA 105
Cdd:PLN03232  636 INLEIPVGSLVAIVGGTGEGKTSLISAML-----GEL-------------SHAETSSVVIRGSVayvpqVSWIFNA---T 694

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  106 LDPVYTVGRQIEETimRHEKVSRGLAAERALALFQKVRIPSPERRLSNypheMSGGMLQRAMIAMALACNPKVLLADEPT 185
Cdd:PLN03232  695 VRENILFGSDFESE--RYWRAIDVTALQHDLDLLPGRDLTEIGERGVN----ISGGQKQRVSMARAVYSNSDIYIFDDPL 768

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 523689182  186 TALDATVQIQIL--LLIRELQreyGLSVIFVTHDIGVAAEVaDRIAVMYAGRIVEEGLVGDIIRN 248
Cdd:PLN03232  769 SALDAHVAHQVFdsCMKDELK---GKTRVLVTNQLHFLPLM-DRIILVSEGMIKEEGTFAELSKS 829

PRK13546

teichoic acids export ABC transporter ATP-binding subunit TagH;

22-246

2.81e-05

teichoic acids export ABC transporter ATP-binding subunit TagH;

Pssm-ID: 184131 [Multi-domain] Cd Length: 264 Bit Score: 44.81 E-value: 2.81e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  22 GKAVKAVNGVSLSVKPGEVVALLGESGSGKSvTMRSLLrlhpKGTL--IEGGMTVDGHDIMSLSNRALSDLRGAVVSMVF 99
Cdd:PRK13546  34 NKTFFALDDISLKAYEGDVIGLVGINGSGKS-TLSNII----GGSLspTVGKVDRNGEVSVIAISAGLSGQLTGIENIEF 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 100 QEPRLALDPvytvgRQIEETIMRHEKVSrglaaERALALFQKVRipsperrlsNYphemSGGMLQRAMIAMALACNPKVL 179
Cdd:PRK13546 109 KMLCMGFKR-----KEIKAMTPKIIEFS-----ELGEFIYQPVK---------KY----SSGMRAKLGFSINITVNPDIL 165

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 523689182 180 LADEPTTALDATVQIQILLLIRELqREYGLSVIFVTHDIGVAAEVADRIAVMYAGRIVEEGLVGDII 246
Cdd:PRK13546 166 VIDEALSVGDQTFAQKCLDKIYEF-KEQNKTIFFVSHNLGQVRQFCTKIAWIEGGKLKDYGELDDVL 231

ABCC_SUR2

cd03288

ATP-binding cassette domain 2 of the sulfonylurea receptor SUR; The SUR domain 2. The ...

9-108

6.09e-05

ATP-binding cassette domain 2 of the sulfonylurea receptor SUR; The SUR domain 2. The sulfonylurea receptor SUR is an ATP binding cassette (ABC) protein of the ABCC/MRP family. Unlike other ABC proteins, it has no intrinsic transport function, neither active nor passive, but associates with the potassium channel proteins Kir6.1 or Kir6.2 to form the ATP-sensitive potassium (K(ATP)) channel. Within the channel complex, SUR serves as a regulatory subunit that fine-tunes the gating of Kir6.x in response to alterations in cellular metabolism. It constitutes a major pharmaceutical target as it binds numerous drugs, K(ATP) channel openers and blockers, capable of up- or down-regulating channel activity.

Pssm-ID: 213255 [Multi-domain] Cd Length: 257 Bit Score: 43.74 E-value: 6.09e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182   9 IDISNLSVTFRRGGKAV-KAVNGVslsVKPGEVVALLGESGSGKSVTMRSLLRLHpkgTLIEGGMTVDGHDIMSLsnrAL 87
Cdd:cd03288   20 IKIHDLCVRYENNLKPVlKHVKAY---IKPGQKVGICGRTGSGKSSLSLAFFRMV---DIFDGKIVIDGIDISKL---PL 90

                         90       100
                 ....*....|....*....|....*...
gi 523689182  88 SDLRgAVVSMVFQEP-------RLALDP 108
Cdd:cd03288   91 HTLR-SRLSIILQDPilfsgsiRFNLDP 117

ABC_Class2

cd03227

ATP-binding cassette domain of non-transporter proteins; ABC-type Class 2 contains systems ...

156-232

9.17e-05

ATP-binding cassette domain of non-transporter proteins; ABC-type Class 2 contains systems involved in cellular processes other than transport. These families are characterized by the fact that the ABC subunit is made up of duplicated, fused ABC modules (ABC2). No known transmembrane proteins or domains are associated with these proteins.

Pssm-ID: 213194 [Multi-domain] Cd Length: 162 Bit Score: 42.35 E-value: 9.17e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 156 HEMSGGMLQRAMIAMALA---CNPKVLLA-DEPTTALDATVQIQILLLIRElQREYGLSVIFVTHDIGVaAEVADRIAVM 231
Cdd:cd03227   76 LQLSGGEKELSALALILAlasLKPRPLYIlDEIDRGLDPRDGQALAEAILE-HLVKGAQVIVITHLPEL-AELADKLIHI 153


                 .
gi 523689182 232 Y 232
Cdd:cd03227  154 K 154

PRK10938

putative molybdenum transport ATP-binding protein ModF; Provisional

32-223

9.46e-05

putative molybdenum transport ATP-binding protein ModF; Provisional

Pssm-ID: 182852 [Multi-domain] Cd Length: 490 Bit Score: 43.85 E-value: 9.46e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  32 SLSVKPGEVVALLGESGSGKSvtmrSLLR-LHPKGTLIEGGMTVDGHDIMSLSNRALSDLrgavVSMVFQEPR---LALD 107
Cdd:PRK10938  23 SLTLNAGDSWAFVGANGSGKS----ALARaLAGELPLLSGERQSQFSHITRLSFEQLQKL----VSDEWQRNNtdmLSPG 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 108 PVYTvGRQIEETIMRHEKvsrglAAERALALFQKVRIPSPERRLSNYpheMSGGMLQRAMIAMALACNPKVLLADEPTTA 187
Cdd:PRK10938  95 EDDT-GRTTAEIIQDEVK-----DPARCEQLAQQFGITALLDRRFKY---LSTGETRKTLLCQALMSEPDLLILDEPFDG 165

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 523689182 188 LDATVQIQILLLIRELQRE-YGLSVI---------FVTHdIGVAAE 223
Cdd:PRK10938 166 LDVASRQQLAELLASLHQSgITLVLVlnrfdeipdFVQF-AGVLAD 210

ABC_CcmA_heme_exporter

cd03231

Cytochrome c biogenesis ATP-binding export protein; CcmA, the ATP-binding component of the ...

20-228

1.60e-04

Cytochrome c biogenesis ATP-binding export protein; CcmA, the ATP-binding component of the bacterial CcmAB transporter. The CCM family is involved in bacterial cytochrome c biogenesis. Cytochrome c maturation in E. coli requires the ccm operon, which encodes eight membrane proteins (CcmABCDEFGH). CcmE is a periplasmic heme chaperon that binds heme covalently and transfers it onto apocytochrome c in the presence of CcmF, CcmG, and CcmH. The CcmAB proteins represent an ABC transporter and the CcmCD proteins participate in heme transfer to CcmE.

Pssm-ID: 213198 [Multi-domain] Cd Length: 201 Bit Score: 42.09 E-value: 1.60e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  20 RGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSvtmrSLLRLhpkgtlIEGGMTVDGHDImSLSNRALSDLRGAVV-SMV 98
Cdd:cd03231   10 RDGRAL--FSGLSFTLAAGEALQVTGPNGSGKT----TLLRI------LAGLSPPLAGRV-LLNGGPLDFQRDSIArGLL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  99 FQEPRLALDPVYTVgrqiEETIMRHEKVSRGLAAERALAlfqKVRIPSPERRLSNYpheMSGGMLQRAMIAMALACNPKV 178
Cdd:cd03231   77 YLGHAPGIKTTLSV----LENLRFWHADHSDEQVEEALA---RVGLNGFEDRPVAQ---LSAGQQRRVALARLLLSGRPL 146

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 523689182 179 LLADEPTTALDATVQIQILLLIRElQREYGLSVIFVTH-DIGVAAEVADRI 228
Cdd:cd03231  147 WILDEPTTALDKAGVARFAEAMAG-HCARGGMVVLTTHqDLGLSEAGAREL 196

AAA_21

pfam13304

AAA domain, putative AbiEii toxin, Type IV TA system; Several members are annotated as being ...

155-220

2.70e-04

AAA domain, putative AbiEii toxin, Type IV TA system; Several members are annotated as being of the abortive phage resistance system, in which case the family would be acting as the toxin for a type IV toxin-antitoxin resistance system.

Pssm-ID: 433102 [Multi-domain] Cd Length: 303 Bit Score: 41.99 E-value: 2.70e-04

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 523689182  155 PHEMSGGMLQ-RAMIAMALACNPK--VLLADEPTTALDATVQIQILLLIRELQREyGLSVIFVTHDIGV 220
Cdd:pfam13304 234 AFELSDGTKRlLALLAALLSALPKggLLLIDEPESGLHPKLLRRLLELLKELSRN-GAQLILTTHSPLL 301

PRK11819

putative ABC transporter ATP-binding protein; Reviewed

17-217

3.39e-04

putative ABC transporter ATP-binding protein; Reviewed

Pssm-ID: 236992 [Multi-domain] Cd Length: 556 Bit Score: 42.03 E-value: 3.39e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  17 TFRRGGKAV----KAVNGVSLSVKPGEVVALLGESGSGKSvtmrSLLRlhpkgtlIEGGMtvdghDIMSLSNRALSDlrG 92
Cdd:PRK11819   8 TMNRVSKVVppkkQILKDISLSFFPGAKIGVLGLNGAGKS----TLLR-------IMAGV-----DKEFEGEARPAP--G 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  93 AVVSMVFQEPRLalDPVYTVGRQIEE-------TIMRHEKVSRGLAA-------------------------------ER 134
Cdd:PRK11819  70 IKVGYLPQEPQL--DPEKTVRENVEEgvaevkaALDRFNEIYAAYAEpdadfdalaaeqgelqeiidaadawdldsqlEI 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 135 AL-ALfqkvRIPSPERRLSNypheMSGGMLQRAMIAMALACNPKVLLADEPTTALDATvqiQILLLIRELQReYGLSVIF 213
Cdd:PRK11819 148 AMdAL----RCPPWDAKVTK----LSGGERRRVALCRLLLEKPDMLLLDEPTNHLDAE---SVAWLEQFLHD-YPGTVVA 215


                 ....
gi 523689182 214 VTHD 217
Cdd:PRK11819 216 VTHD 219

ABC_Rad50

cd03240

ATP-binding cassette domain of Rad50; The catalytic domains of Rad50 are similar to the ...

158-232

4.81e-04

ATP-binding cassette domain of Rad50; The catalytic domains of Rad50 are similar to the ATP-binding cassette of ABC transporters, but are not associated with membrane-spanning domains. The conserved ATP-binding motifs common to Rad50 and the ABC transporter family include the Walker A and Walker B motifs, the Q loop, a histidine residue in the switch region, a D-loop, and a conserved LSGG sequence. This conserved sequence, LSGG, is the most specific and characteristic motif of this family and is thus known as the ABC signature sequence.

Pssm-ID: 213207 [Multi-domain] Cd Length: 204 Bit Score: 40.67 E-value: 4.81e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 158 MSGGmlQRAMIAMALAC--------NPKVLLADEPTTALDA-TVQIQILLLIRELQREYGLSVIFVTHDigvaAEVADRI 228
Cdd:cd03240  116 CSGG--EKVLASLIIRLalaetfgsNCGILALDEPTTNLDEeNIEESLAEIIEERKSQKNFQLIVITHD----EELVDAA 189


                 ....
gi 523689182 229 AVMY 232
Cdd:cd03240  190 DHIY 193

PTZ00243

ABC transporter; Provisional

158-285

9.01e-04

ABC transporter; Provisional

Pssm-ID: 240327 [Multi-domain] Cd Length: 1560 Bit Score: 41.30 E-value: 9.01e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  158 MSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQIlllIRE--LQREYGLSVIFVTHDIGVAAEvADRIAVMYAGR 235
Cdd:PTZ00243  783 LSGGQKARVSLARAVYANRDVYLLDDPLSALDAHVGERV---VEEcfLGALAGKTRVLATHQVHVVPR-ADYVVALGDGR 858

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 523689182  236 IVEEGLVGDIIRNPRHPYTKGLLGARVELAEG-RDRLVTIPGAPPDLAAMP 285
Cdd:PTZ00243  859 VEFSGSSADFMRTSLYATLAAELKENKDSKEGdADAEVAEVDAAPGGAVDH 909

PTZ00265

multidrug resistance protein (mdr1); Provisional

157-216

9.45e-04

multidrug resistance protein (mdr1); Provisional

Pssm-ID: 240339 [Multi-domain] Cd Length: 1466 Bit Score: 41.17 E-value: 9.45e-04

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  157 EMSGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREYGLSVIFVTH 216
Cdd:PTZ00265  579 KLSGGQKQRISIARAIIRNPKILILDEATSSLDNKSEYLVQKTINNLKGNENRITIIIAH 638

ABC2_perm_RbbA

NF033858

ribosome-associated ATPase/putative transporter RbbA;

16-240

1.03e-03

ribosome-associated ATPase/putative transporter RbbA;

Pssm-ID: 468210 [Multi-domain] Cd Length: 907 Bit Score: 40.88 E-value: 1.03e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  16 VTFRRGgkAVKAVNGVSLSVKPGEVVALLGESGSGKSvtmrSLLrlhpkgTLI-------EGGMTVDGHDIMSLSNRAls 88
Cdd:NF033858   7 VSHRYG--KTVALDDVSLDIPAGCMVGLIGPDGVGKS----SLL------SLIagarkiqQGRVEVLGGDMADARHRR-- 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  89 dlrgAVVsmvfqePRLA---------LDPVYTVgrqiEETImrhEKVSR--GL-AAERAlalfqkVRI----------PS 146
Cdd:NF033858  73 ----AVC------PRIAympqglgknLYPTLSV----FENL---DFFGRlfGQdAAERR------RRIdellratglaPF 129

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 147 PER---RLSnyphemsGGMLQRAMIAMALACNPKVLLADEPTTALDATVQIQILLLIRELQREY-GLSVIfvthdigVA- 221
Cdd:NF033858 130 ADRpagKLS-------GGMKQKLGLCCALIHDPDLLILDEPTTGVDPLSRRQFWELIDRIRAERpGMSVL-------VAt 195

                        250       260
                 ....*....|....*....|....
gi 523689182 222 -----AEVADRIAVMYAGRIVEEG 240
Cdd:NF033858 196 aymeeAERFDWLVAMDAGRVLATG 219

ABCC_SUR1_N

cd03290

ATP-binding cassette domain of the sulfonylurea receptor, subfamily C; The SUR domain 1. The ...

158-234

1.47e-03

ATP-binding cassette domain of the sulfonylurea receptor, subfamily C; The SUR domain 1. The sulfonylurea receptor SUR is an ATP transporter of the ABCC/MRP family with tandem ATPase binding domains. Unlike other ABC proteins, it has no intrinsic transport function, neither active nor passive, but associates with the potassium channel proteins Kir6.1 or Kir6.2 to form the ATP-sensitive potassium (K(ATP)) channel. Within the channel complex, SUR serves as a regulatory subunit that fine-tunes the gating of Kir6.x in response to alterations in cellular metabolism. It constitutes a major pharmaceutical target as it binds numerous drugs, K(ATP) channel openers and blockers, capable of up- or down-regulating channel activity.

Pssm-ID: 213257 [Multi-domain] Cd Length: 218 Bit Score: 39.24 E-value: 1.47e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 158 MSGGMLQRAMIAMALACNPKVLLADEPTTALDA-----TVQIQILLLIRELQReyglSVIFVTHDIGVAAEvADRIAVMY 232
Cdd:cd03290  141 LSGGQRQRICVARALYQNTNIVFLDDPFSALDIhlsdhLMQEGILKFLQDDKR----TLVLVTHKLQYLPH-ADWIIAMK 215


                 ..
gi 523689182 233 AG 234
Cdd:cd03290  216 DG 217

PRK13538

cytochrome c biogenesis heme-transporting ATPase CcmA;

8-61

2.28e-03

cytochrome c biogenesis heme-transporting ATPase CcmA;

Pssm-ID: 184125 [Multi-domain] Cd Length: 204 Bit Score: 38.63 E-value: 2.28e-03

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 523689182   8 MIDISNLsvTFRRGGKAVkaVNGVSLSVKPGEVVALLGESGSGKSvtmrSLLRL 61
Cdd:PRK13538   1 MLEARNL--ACERDERIL--FSGLSFTLNAGELVQIEGPNGAGKT----SLLRI 46

PvdE

COG4615

ABC-type siderophore export system, fused ATPase and permease components [Inorganic ion ...

31-238

6.73e-03

ABC-type siderophore export system, fused ATPase and permease components [Inorganic ion transport and metabolism];

Pssm-ID: 443659 [Multi-domain] Cd Length: 547 Bit Score: 38.24 E-value: 6.73e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182  31 VSLSVKPGEVVALLGESGSGKSVTMRSLLRLHPKGtliEGGMTVDGHDIMSLSNRALSDLRGAVVSMVFQEPRLaldpvy 110
Cdd:COG4615  351 IDLTIRRGELVFIVGGNGSGKSTLAKLLTGLYRPE---SGEILLDGQPVTADNREAYRQLFSAVFSDFHLFDRL------ 421

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523689182 111 tvgrqieetIMRHEKVSRGLAAE--RALALFQKVRIpsPERRLSNYphEMSGGmlQRAMIAMALAcnpkvLLADEPttal 188
Cdd:COG4615  422 ---------LGLDGEADPARAREllERLELDHKVSV--EDGRFSTT--DLSQG--QRKRLALLVA-----LLEDRP---- 477

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 523689182 189 datvqiqILL-------------------LIRELQREyGLSVIFVTHDiGVAAEVADRIAVMYAGRIVE 238
Cdd:COG4615  478 -------ILVfdewaadqdpefrrvfyteLLPELKAR-GKTVIAISHD-DRYFDLADRVLKMDYGKLVE 537

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01