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Conserved domains on  [gi|523681504|ref|WP_020803879|]
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MULTISPECIES: antirestriction protein ArdA [Enterobacteriaceae]

Protein Classification

antirestriction protein ArdA( domain architecture ID 10008776)

antirestriction protein ArdA allows associated mobile genetic elements to evade the ubiquitous Type I DNA restriction systems, assisting in the spread of resistance genes in bacteria

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArdA COG4734
Antirestriction protein ArdA [Defense mechanisms];
1-168 3.26e-58

Antirestriction protein ArdA [Defense mechanisms];


:

Pssm-ID: 443768  Cd Length: 173  Bit Score: 179.36  E-value: 3.26e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523681504   1 MHSSITTPAVYVGTYHQYNCGSIFGKWFDLTDfdDEDAFYDACRTLHAG---EEDPELMFQDWEGIPSPFASESSVKWAF 77
Cdd:COG4734    1 MTTTETTPRIYVACLAAYNNGSLHGKWIDATQ--DVEEIQEAIREMLADspvEDAEEWAIHDYEGFPGATISEYESLEKV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523681504  78 IEAFRQAQDDGRAaaFVAWAEYTG--ECDYDAFDDAYYGEAESEEDFAYGFVEDNGLLNEVPESLRVYFDYEAYARDLFS 155
Cdd:COG4734   79 FELAEFIEEHGEA--FAAWLDHFGglEDAEEAFEDAYQGEYDSEADFAEELIEETGLLLEIPESLARYIDYEAYARDLFL 156

                        170
                 ....*....|....*..
gi 523681504 156 DGYVFHDG----YVFRN 168
Cdd:COG4734  157 SDYVTVEGgfevHVFWN 173
 
Name Accession Description Interval E-value
ArdA COG4734
Antirestriction protein ArdA [Defense mechanisms];
1-168 3.26e-58

Antirestriction protein ArdA [Defense mechanisms];


Pssm-ID: 443768  Cd Length: 173  Bit Score: 179.36  E-value: 3.26e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523681504   1 MHSSITTPAVYVGTYHQYNCGSIFGKWFDLTDfdDEDAFYDACRTLHAG---EEDPELMFQDWEGIPSPFASESSVKWAF 77
Cdd:COG4734    1 MTTTETTPRIYVACLAAYNNGSLHGKWIDATQ--DVEEIQEAIREMLADspvEDAEEWAIHDYEGFPGATISEYESLEKV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523681504  78 IEAFRQAQDDGRAaaFVAWAEYTG--ECDYDAFDDAYYGEAESEEDFAYGFVEDNGLLNEVPESLRVYFDYEAYARDLFS 155
Cdd:COG4734   79 FELAEFIEEHGEA--FAAWLDHFGglEDAEEAFEDAYQGEYDSEADFAEELIEETGLLLEIPESLARYIDYEAYARDLFL 156

                        170
                 ....*....|....*..
gi 523681504 156 DGYVFHDG----YVFRN 168
Cdd:COG4734  157 SDYVTVEGgfevHVFWN 173
ArdA pfam07275
Antirestriction protein (ArdA); This family consists of several bacterial antirestriction ...
 10-166 2.82e-32

Antirestriction protein (ArdA); This family consists of several bacterial antirestriction (ArdA) proteins. ArdA functions in bacterial conjugation to allow an unmodified plasmid to evade restriction in the recipient bacterium and yet acquire cognate modification.


Pssm-ID: 462130  Cd Length: 151  Bit Score: 112.72  E-value: 2.82e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523681504   10 VYVGTYHQYNCGSIFGKWFDLTDfdDEDAFYDACRTLHA-GEEDPELMFQDWEGIPSpfaseSSVKWAFIEAFRQAqddg 88
Cdd:pfam07275   1 IYVANLAKYNNGELVGEWLDLPA--DAEELQEALRRIGAeGEEYEEYAIHDYEGFGF-----TLGEYESIDELNEL---- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523681504   89 rAAAFVAWAEYTGECDYDAFDDAYYGEAESEE---DFAYGFVEDNGLLNEVPESLRVYFDYEAYARDLFSDGYVF--HDG 163
Cdd:pfam07275  70 -AALLEELAEHDLEEFEAAFEERYAGEYDSLIqnlDYAYYYVEELGELDEIPEELENYFDYEAYGRDLFLDGDGVftETG 148


                  ...
gi 523681504  164 YVF 166
Cdd:pfam07275 149 YVE 151
 
Name Accession Description Interval E-value
ArdA COG4734
Antirestriction protein ArdA [Defense mechanisms];
1-168 3.26e-58

Antirestriction protein ArdA [Defense mechanisms];


Pssm-ID: 443768  Cd Length: 173  Bit Score: 179.36  E-value: 3.26e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523681504   1 MHSSITTPAVYVGTYHQYNCGSIFGKWFDLTDfdDEDAFYDACRTLHAG---EEDPELMFQDWEGIPSPFASESSVKWAF 77
Cdd:COG4734    1 MTTTETTPRIYVACLAAYNNGSLHGKWIDATQ--DVEEIQEAIREMLADspvEDAEEWAIHDYEGFPGATISEYESLEKV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523681504  78 IEAFRQAQDDGRAaaFVAWAEYTG--ECDYDAFDDAYYGEAESEEDFAYGFVEDNGLLNEVPESLRVYFDYEAYARDLFS 155
Cdd:COG4734   79 FELAEFIEEHGEA--FAAWLDHFGglEDAEEAFEDAYQGEYDSEADFAEELIEETGLLLEIPESLARYIDYEAYARDLFL 156

                        170
                 ....*....|....*..
gi 523681504 156 DGYVFHDG----YVFRN 168
Cdd:COG4734  157 SDYVTVEGgfevHVFWN 173
ArdA pfam07275
Antirestriction protein (ArdA); This family consists of several bacterial antirestriction ...
 10-166 2.82e-32

Antirestriction protein (ArdA); This family consists of several bacterial antirestriction (ArdA) proteins. ArdA functions in bacterial conjugation to allow an unmodified plasmid to evade restriction in the recipient bacterium and yet acquire cognate modification.


Pssm-ID: 462130  Cd Length: 151  Bit Score: 112.72  E-value: 2.82e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523681504   10 VYVGTYHQYNCGSIFGKWFDLTDfdDEDAFYDACRTLHA-GEEDPELMFQDWEGIPSpfaseSSVKWAFIEAFRQAqddg 88
Cdd:pfam07275   1 IYVANLAKYNNGELVGEWLDLPA--DAEELQEALRRIGAeGEEYEEYAIHDYEGFGF-----TLGEYESIDELNEL---- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523681504   89 rAAAFVAWAEYTGECDYDAFDDAYYGEAESEE---DFAYGFVEDNGLLNEVPESLRVYFDYEAYARDLFSDGYVF--HDG 163
Cdd:pfam07275  70 -AALLEELAEHDLEEFEAAFEERYAGEYDSLIqnlDYAYYYVEELGELDEIPEELENYFDYEAYGRDLFLDGDGVftETG 148


                  ...
gi 523681504  164 YVF 166
Cdd:pfam07275 149 YVE 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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