|
Name |
Accession |
Description |
Interval |
E-value |
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
7-598 |
0e+00 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 1109.05 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 7 FRSIHFKFVIIYVLLILVAMQIIGVYFVRKLETELVQNFKNSLNERVTLLAYNVEQAMNRERDEkSPTLEEDIRSLLHDF 86
Cdd:NF033092 2 FRSIHFKIVLIYVLLILIAMQIIGVYFVRQLETQLLNNFKESINLRANLLSYNLEQELSKEDED-DETLEEDIRTILNDF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 87 VSQDISEVRVIDEKGKVLATSNPYMQNIVGKRTTEIYVKRSLVTGEIVDRMLLDSKTGHRMYISSTPIKTS-GEIKGVIY 165
Cdd:NF033092 81 NNNDISEIQVIDAKGTILGTSDPSNQSIVGQKTTDSDVKRALLGGKDNEKILIDPEDNNRVYVLATPIKSSnGEVVGAIY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 166 VIASMENVFSQMRQINMILATGTGIALAITAVLGIFLSRTITRPISDMRRQALAMTRGDFSRKVKVYGYDEIGQLAMTFN 245
Cdd:NF033092 161 IEASMESVYDQMNNINLIFATGTLIALVITAVLGILLARTITRPIKEMRKQALAMAKGDFSRKVKVYGNDEIGQLAEAFN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 246 NLTKKLQEAQATTEGERRKLESVLTHMTDGVIATDRRGRVILINDAALNILNVSRETVLSSSIVDVLGIADQYTFETLLE 325
Cdd:NF033092 241 NLTKRLQEAQATTESERRKLDSVLSHMTDGVIATDRRGRVILINDPALEMLNVSRETVLGQSILDVLGLEEEYTLRDLLE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 326 ERDSLILDFSTDEELYILRASLSVIQKEGGFVNGLIVVLHDITEQEKIDRERRQFVANVSHELRTPLTTMKSYLEALADG 405
Cdd:NF033092 321 EQDSLLLDFSTEEEPLILRANFSVIQRESGFINGLIAVLHDVTEQEKIEQERREFVANVSHELRTPLTTMRSYLEALADG 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 406 AWQDKDIAPRFIQVVQNETERMIRLVNDLLHLSKLDSKDYKLKKTWINFSAYFHKVIDRFEL-TKSDNIRFVRKIPREAI 484
Cdd:NF033092 401 AWKDPELAPRFLGVTQNETERMIRLVNDLLQLSRMDSKDYKLNKEWVNFNEFFNYIIDRFEMiLKNKNITFKREFPKRDL 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 485 FIEVDEDKITQVLDNIISNALKYSPQGGTITFRVRKLSDEMIVSVSDEGVGIPKADLAKIFERFYRVDKARSRKLGGTGL 564
Cdd:NF033092 481 WVEIDTDKITQVLDNIISNAIKYSPEGGTITFRLLETHNRIIISISDQGLGIPKKDLDKIFDRFYRVDKARSRKMGGTGL 560
|
570 580 590
....*....|....*....|....*....|....
gi 523588760 565 GLAIAKEVVLAHGGTIWAESKEHKGTTIYFTLPL 598
Cdd:NF033092 561 GLAIAKEVVEAHGGRIWAESEEGKGTTIYFTLPY 594
|
|
| HK_VicK |
NF033093 |
cell wall metabolism sensor histidine kinase VicK; This model describes the protein VicK (or ... |
223-606 |
5.21e-137 |
|
cell wall metabolism sensor histidine kinase VicK; This model describes the protein VicK (or WalK) as found in Streptococcus pneumoniae, This protein is shorter than the WalK of Staphylococcus aureus, although apparently is functionally similar. Compare to model NF033092 (HK_WalK). VicK is a sensor histidine kinase involved in regulating cell wall metabolism. Its two component system partner is the response regulatory VicR.
Pssm-ID: 467965 [Multi-domain] Cd Length: 448 Bit Score: 406.80 E-value: 5.21e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 223 GDFSRKVKVYGYDEIGQLAMTFNNLTKKLQEAQATTEGERRKLESVLTHMTDGVIATDRRGRVILINDAALNILNVSRET 302
Cdd:NF033093 54 GDYSEVLDMQGDPELTELTNSLNDLSEVFRLTHENLEQEKNRLASILSYMTDGVLATNRRGQIIMINDTAQKQLNVKREE 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 303 VLSSSIVDVLGIADQYTFETLLEERDSLILDfSTDE--ELYILRASLSVIQKEGGFVNGLIVVLHDITEQEKIDRERRQF 380
Cdd:NF033093 134 ALNMNILDLLDIDDEYDLRDLITKTPELTLD-SRDEngEFLSLRVRFALIRRESGFISGLVAVLHDTTEQEKEERERRLF 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 381 VANVSHELRTPLTTMKSYLEALADGAWqDKDIAPRFIQVVQNETERMIRLVNDLLHLSKLDSKDYKLKKTWINFSAYFHK 460
Cdd:NF033093 213 VSNVSHELRTPLTSVKSYLEALDEGAL-SEPVAPSFIKVSLDETNRMMRMISDLLSLSRIDNQTSHLDVELTNFTAFITF 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 461 VIDRFELTKSDN------IRFVRKIPREAIFIEVDEDKITQVLDNIISNALKYSPQGGTITFRVRKLSDEMIVSVSDEGV 534
Cdd:NF033093 292 ILNRFDQIKSQDtetgkkYEIVRDYPITSIWVEIDTDKMTQVIDNILNNAIKYSPDGGKITVSMKTTDTQLIISISDEGL 371
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 523588760 535 GIPKADLAKIFERFYRVDKARSRKLGGTGLGLAIAKEVVLAHGGTIWAESKEHKGTTIYFTLPLERE--QKDDW 606
Cdd:NF033093 372 GIPKKDLPLIFDRFYRVDKARSRAQGGTGLGLAIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDavKDDEW 445
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
284-601 |
1.80e-109 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 334.21 E-value: 1.80e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 284 RVILINDAALNILNVSRETVLSSSIVDVLGIADQYTFETLLEERDSLILDFSTDEELYILRASLSVIQKEGGFVNGLIVV 363
Cdd:COG5002 72 LLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAV 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 364 LHDITEQEKIDRERRQFVANVSHELRTPLTTMKSYLEALADGAWQDKDIAPRFIQVVQNETERMIRLVNDLLHLSKLDSK 443
Cdd:COG5002 152 ERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESG 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 444 DYKLKKTWINFSAYFHKVIDRFE-LTKSDNIRFVRKIPREAIFIEVDEDKITQVLDNIISNALKYSPQGGTITFRVRKLS 522
Cdd:COG5002 232 ELKLEKEPVDLAELLEEVVEELRpLAEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREED 311
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 523588760 523 DEMIVSVSDEGVGIPKADLAKIFERFYRVDKARSRKLGGTGLGLAIAKEVVLAHGGTIWAESKEHKGTTIYFTLPLERE 601
Cdd:COG5002 312 DQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLARE 390
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
180-603 |
7.64e-95 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 297.26 E-value: 7.64e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 180 INMILATGTGIALAITAVLGIFLSRTITRPISDMRRQALAMTRGDFSRKVKVYGYDEIGQLAMTFNNLTKKLQEAQATTE 259
Cdd:COG5000 7 FLLLLLLIALLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKEQREELE 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 260 GERRKLESVLTHMTDGVIATDRRGRVILINDAALNILNVSRETVLSSSIVDVLGIADQY-TFETLLEERDSLILDFSTDE 338
Cdd:COG5000 87 ERRRYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGKPLEELLPELDLAeLLREALERGWQEEIELTRDG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 339 ELyILRASLSVIQkeggfVNGLIVVLHDITEQEKIDRER--RQFVANVSHELRTPLTTMKSYLE----ALADGAWQDKDI 412
Cdd:COG5000 167 RR-TLLVRASPLR-----DDGYVIVFDDITELLRAERLAawGELARRIAHEIKNPLTPIQLSAErlrrKLADKLEEDRED 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 413 APRFIQVVQNETERMIRLVNDLLHLSKLDskdyKLKKTWINFSAYFHKVIDRFELT-KSDNIRFVRKIPREAIFIEVDED 491
Cdd:COG5000 241 LERALDTIIRQVDRLKRIVDEFLDFARLP----EPQLEPVDLNELLREVLALYEPAlKEKDIRLELDLDPDLPEVLADRD 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 492 KITQVLDNIISNALKYSPQGGTITFRVRKLSDEMIVSVSDEGVGIPKADLAKIFERFYrvdkarSRKLGGTGLGLAIAKE 571
Cdd:COG5000 317 QLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFF------TTKPKGTGLGLAIVKK 390
|
410 420 430
....*....|....*....|....*....|..
gi 523588760 572 VVLAHGGTIWAESKEHKGTTIYFTLPLEREQK 603
Cdd:COG5000 391 IVEEHGGTIELESRPGGGTTFTIRLPLAEEAE 422
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
369-601 |
3.39e-84 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 263.31 E-value: 3.39e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 369 EQEKIDRERRQFVANVSHELRTPLTTMKSYLEALADGAWQDKDIAPRFIQVVQNETERMIRLVNDLLHLSKLDSKDYKLK 448
Cdd:COG2205 8 ELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLESGKLSLE 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 449 KTWINFSAYFHKVIDRFELT-KSDNIRFVRKIPREAIFIEVDEDKITQVLDNIISNALKYSPQGGTITFRVRKLSDEMIV 527
Cdd:COG2205 88 LEPVDLAELLEEAVEELRPLaEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREGDGVRI 167
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 523588760 528 SVSDEGVGIPKADLAKIFERFYRVDKARSRklGGTGLGLAIAKEVVLAHGGTIWAESKEHKGTTIYFTLPLERE 601
Cdd:COG2205 168 SVSDNGPGIPEEELERIFERFYRGDNSRGE--GGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAES 239
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
276-599 |
1.39e-75 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 244.05 E-value: 1.39e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 276 VIATDRRGRVILINDAALNILNVSRETVLSSSIVDVLGIADQYTFETLLEERDSLILDFSTDEELYILRASLSVIQKEGG 355
Cdd:COG0642 9 VLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 356 FVNGLIVVLHDITEQEKIDRERRQFVANVSHELRTPLTTMKSYLEALADGAwqDKDIApRFIQVVQNETERMIRLVNDLL 435
Cdd:COG0642 89 LLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEEL--DEEQR-EYLETILRSADRLLRLINDLL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 436 HLSKLDSKDYKLKKTWINFSAYFHKVIDRFE-LTKSDNIRFVRKIPREAIFIEVDEDKITQVLDNIISNALKYSPQGGTI 514
Cdd:COG0642 166 DLSRLEAGKLELEPEPVDLAELLEEVVELFRpLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTV 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 515 TFRVRKLSDEMIVSVSDEGVGIPKADLAKIFERFYRVDKARSRklGGTGLGLAIAKEVVLAHGGTIWAESKEHKGTTIYF 594
Cdd:COG0642 246 TVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRG--GGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTV 323
|
....*
gi 523588760 595 TLPLE 599
Cdd:COG0642 324 TLPLA 328
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
263-596 |
1.84e-74 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 241.34 E-value: 1.84e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 263 RKLESVLTHMTDGVIATDRRGRVILINDAALNILNVSRETVLSSSIVDVLGIAD--QYTFETLLEErdSLILDFSTDEEL 340
Cdd:TIGR02966 6 SRFRAAAQALPDAVVVLDEEGQIEWCNPAAERLLGLRWPDDLGQRITNLIRHPEfvEYLAAGRFSE--PLELPSPINSER 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 341 YIlraslsVIQKEGGFVNGLIVVLHDITEQEKIDRERRQFVANVSHELRTPLTTMKSYLEALADGAWQDKDIAPRFIQVV 420
Cdd:TIGR02966 84 VL------EIRIAPYGEEQKLLVARDVTRLRRLEQMRRDFVANVSHELRTPLTVLRGYLETLADGPDEDPEEWNRALEIM 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 421 QNETERMIRLVNDLLHLSKLDSKDYKLKKTWINFSAYFHKVIDRFE-LTKSDNIRFVRKIPReAIFIEVDEDKITQVLDN 499
Cdd:TIGR02966 158 LEQSQRMQSLVEDLLTLSRLESAASPLEDEPVDMPALLDHLRDEAEaLSQGKNHQITFEIDG-GVDVLGDEDELRSAFSN 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 500 IISNALKYSPQGGTITFRVRKLSDEMIVSVSDEGVGIPKADLAKIFERFYRVDKARSRKLGGTGLGLAIAKEVVLAHGGT 579
Cdd:TIGR02966 237 LVSNAIKYTPEGGTITVRWRRDGGGAEFSVTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHAR 316
|
330
....*....|....*..
gi 523588760 580 IWAESKEHKGTTIYFTL 596
Cdd:TIGR02966 317 LEIESELGKGSTFSFIF 333
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
261-605 |
1.66e-66 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 221.26 E-value: 1.66e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 261 ERRKLESVLTHMTDGVIATDRRGRVILINDAALNILNVSRETVLSSSIVDVLGIADQYT--FETLLEERDSLI---LDFS 335
Cdd:COG3852 5 SEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFPEDSPLRelLERALAEGQPVTereVTLR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 336 T-DEELYILRASLSVIQKEGGFVnGLIVVLHDITEQEKIDRERRQ---------FVANVSHELRTPLTTMKSYLEALADG 405
Cdd:COG3852 85 RkDGEERPVDVSVSPLRDAEGEG-GVLLVLRDITERKRLERELRRaeklaavgeLAAGLAHEIRNPLTGIRGAAQLLERE 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 406 AWQDKDiaPRFIQVVQNETERMIRLVNDLLHLSKLDSkdykLKKTWINFsayfHKVIDR----FELTKSDNIRFVRKIPR 481
Cdd:COG3852 164 LPDDEL--REYTQLIIEEADRLNNLVDRLLSFSRPRP----PEREPVNL----HEVLERvlelLRAEAPKNIRIVRDYDP 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 482 EAIFIEVDEDKITQVLDNIISNALKYSPQGGTITFRVRKLSDEMI----------VSVSDEGVGIPKADLAKIFERFYrv 551
Cdd:COG3852 234 SLPEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVERQVTLgglrprlyvrIEVIDNGPGIPEEILDRIFEPFF-- 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 523588760 552 dkarSRKLGGTGLGLAIAKEVVLAHGGTIWAESKEHKGTTIYFTLPLEREQKDD 605
Cdd:COG3852 312 ----TTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQAEEEP 361
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
153-604 |
5.32e-63 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 218.68 E-value: 5.32e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 153 PIKTSGEIKGVIYVIASMENVFSQMRQINMILATGTGIALAITAVLGIFLSRTITRPISDMRrQALAMTRGDFSRKV-KV 231
Cdd:PRK11360 161 PIERNGEVIGYIWANELTEDIRRQAWKMDRRIYAVLAAGLVIGLLLIFLLSRRFSANVDIIK-DGLSTLENDLSTRLpPL 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 232 YGydEIGQLAMTFNNLTKKLQEAQATTEgerrkleSVLTHMTDGVIATDRRGRVILINDAALNILNVSRETVLSSSIVDV 311
Cdd:PRK11360 240 PG--ELGEISQAINNLAQALRETRSLNE-------LILESIADGVIAIDRQGKITTMNPAAEVITGLQRHELVGKPYSEL 310
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 312 LGIADQY------TFETLLEERDSLIlDFSTDEELYILRASLSVIQKEGGFVNGLIVVLHDITEQEKIDRE-RRQ----- 379
Cdd:PRK11360 311 FPPNTPFasplldTLEHGTEHVDLEI-SFPGRDRTIELSVSTSLLHNTHGEMIGALVIFSDLTERKRLQRRvARQerlaa 389
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 380 ---FVANVSHELRTPLTTMKSYLEALADgawQDKDIA-PRFIQVVQNETERMIRLVNDLLHLSKldskDYKLKKTWINFS 455
Cdd:PRK11360 390 lgeLVAGVAHEIRNPLTAIRGYVQIWRQ---QTSDPPsQEYLSVVLREVDRLNKVIDQLLEFSR----PRESQWQPVSLN 462
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 456 AYFHKVIDRFELT-KSDNIRFVRKIPREAIFIEVDEDKITQVLDNIISNALKYSPQGGTITFRVRKLSD-EMIVSVSDEG 533
Cdd:PRK11360 463 ALVEEVLQLFQTAgVQARVDFETELDNELPPIWADPELLKQVLLNILINAVQAISARGKIRIRTWQYSDgQVAVSIEDNG 542
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 523588760 534 VGIPKADLAKIFERFYrvdkarSRKLGGTGLGLAIAKEVVLAHGGTIWAESKEHKGTTIYFTLPLEREQKD 604
Cdd:PRK11360 543 CGIDPELLKKIFDPFF------TTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINPQGNQ 607
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
262-603 |
9.72e-57 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 199.05 E-value: 9.72e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 262 RRKLESVLTHMTDGVIATDRRGRVILINDAALNILNVSRETVLSSSIVDVLGIADQYTFETLLEE--RDSLILDF----- 334
Cdd:COG5809 140 EEKFRLIFNHSPDGIIVTDLDGRIIYANPAACKLLGISIEELIGKSILELIHSDDQENVAAFISQllKDGGIAQGevrfw 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 335 STDEELYILRASLSVIQKEGGfVNGLIVVLHDITEQEKIDRERR---------QFVANVSHELRTPLTTMKSYLEALADG 405
Cdd:COG5809 220 TKDGRWRLLEASGAPIKKNGE-VDGIVIIFRDITERKKLEELLRkseklsvvgELAAGIAHEIRNPLTSLKGFIQLLKDT 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 406 AWQDKDiapRFIQVVQNETERMIRLVNDLLHLSKLDSKDYKLKktwiNFSAYFHKVIDRFElTKSD--NIRFVRKIPREA 483
Cdd:COG5809 299 IDEEQK---TYLDIMLSELDRIESIISEFLVLAKPQAIKYEPK----DLNTLIEEVIPLLQ-PQALlkNVQIELELEDDI 370
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 484 IFIEVDEDKITQVLDNIISNALKYSPQGGTITFRVRKLSDE-MIVSVSDEGVGIPKADLAKIFERFYrvdkarSRKLGGT 562
Cdd:COG5809 371 PDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKAEDDDkVVISVTDEGCGIPEERLKKLGEPFY------TTKEKGT 444
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 523588760 563 GLGLAIAKEVVLAHGGTIWAESKEHKGTTIYFTLPLEREQK 603
Cdd:COG5809 445 GLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIKLSEQ 485
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
176-601 |
2.82e-52 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 187.30 E-value: 2.82e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 176 QMRQINMILATGTGIALAITAVLGIFLSRTITRPISDMRRQALAMTRGDFSRKVKVYGYDEIGQLAMTFNNLTKKLQEAQ 255
Cdd:COG4251 95 ALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAA 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 256 ATTEGERRKLESVLTHMTDGVIATDRRGRVILINDAALNILNVSRETVLSSSIVDVLGIADQYTFETLLEERDSLILDFS 335
Cdd:COG4251 175 LAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLEL 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 336 TDEELYILRASLSVIQKeggfvnglivvlhdITEQEKIDRERRQFVANVSHELRTPLTTMKSYLEALA-DGAWQDKDIAP 414
Cdd:COG4251 255 LELRLELEELEEELEER--------------TAELERSNEELEQFAYVASHDLREPLRKISGFSQLLEeDYGDKLDEEGR 320
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 415 RFIQVVQNETERMIRLVNDLLHLSKLDSKDykLKKTWINFSAYFHKVIDRFELT-KSDNIRF-VRKIPReaifIEVDEDK 492
Cdd:COG4251 321 EYLERIRDAAERMQALIDDLLAYSRVGRQE--LEFEPVDLNELLEEVLEDLEPRiEERGAEIeVGPLPT----VRGDPTL 394
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 493 ITQVLDNIISNALKYSPQG--GTITFRVRKLSDEMIVSVSDEGVGIPKADLAKIFERFYRVDkaRSRKLGGTGLGLAIAK 570
Cdd:COG4251 395 LRQVFQNLISNAIKYSRPGepPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLH--SRDEYEGTGIGLAIVK 472
|
410 420 430
....*....|....*....|....*....|.
gi 523588760 571 EVVLAHGGTIWAESKEHKGTTIYFTLPLERE 601
Cdd:COG4251 473 KIVERHGGRIWVESEPGEGATFYFTLPKAPA 503
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
360-597 |
1.51e-47 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 172.50 E-value: 1.51e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 360 LIVVLHDITEQEKIDRERRQFVANVSHELRTPLTTMKSYLEALADgawQDKDIAPR--FIQVVQNETERMIRLVNDLLHL 437
Cdd:PRK11006 187 LLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQD---QPLEGALRekALHTMREQTQRMEGLVKQLLTL 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 438 SKLDSKDYKLKKTWINFSAYFhKVIDRFELTKSDNirfvrkipREAIFIEVD--------EDKITQVLDNIISNALKYSP 509
Cdd:PRK11006 264 SKIEAAPTIDLNEKVDVPMML-RVLEREAQTLSQG--------KHTITFEVDnslkvfgnEDQLRSAISNLVYNAVNHTP 334
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 510 QGGTITFRVRKLSDEMIVSVSDEGVGIPKADLAKIFERFYRVDKARSRKLGGTGLGLAIAKEVVLAHGGTIWAESKEHKG 589
Cdd:PRK11006 335 EGTHITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKG 414
|
....*...
gi 523588760 590 TTIYFTLP 597
Cdd:PRK11006 415 TRFSFVLP 422
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
163-598 |
1.20e-44 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 166.06 E-value: 1.20e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 163 VIYVIASMENVFSQMRQinmiLATGTGIALAITAVLGIFLSRTITRPISDMRRQALAMTRGDFSRKVKVYG-----YDEI 237
Cdd:COG5805 56 VIYINPAMEKLLGYTSE----EIIGKTIFDFLEKEYHYRVKTRIERLQKGYDVVMIEQIYCKDGELIYVEVklfpiYNQN 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 238 GQLAM-TFNNLTKKLQeAQATTEGERRKLESVLTHMTDGVIATDRRGRVILINDAALNILNVSRETVLSSSIVDVLGIAD 316
Cdd:COG5805 132 GQAAIlALRDITKKKK-IEEILQEQEERLQTLIENSPDLICVIDTDGRILFINESIERLFGAPREELIGKNLLELLHPCD 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 317 QYTF----ETLLEERDSLILDFS---TDEELYILRASLSVIQKEGGFVNGLIVVLHDITEQEKIDRERR---------QF 380
Cdd:COG5805 211 KEEFkeriESITEVWQEFIIEREiitKDGRIRYFEAVIVPLIDTDGSVKGILVILRDITEKKEAEELMArseklsiagQL 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 381 VANVSHELRTPLTTMKSYLEALADGAWQDKDiaprFIQVVQNETERMIRLVNDLLHLSKLDSkdYKLKKTWINfsayfhK 460
Cdd:COG5805 291 AAGIAHEIRNPLTSIKGFLQLLQPGIEDKEE----YFDIMLSELDRIESIISEFLALAKPQA--VNKEKENIN------E 358
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 461 VI-DRFELTKSD----NIRFVRKIPREAIFIEVDEDKITQVLDNIISNALKYSPQGGTITFRVRKLSDEMIVSVSDEGVG 535
Cdd:COG5805 359 LIqDVVTLLETEailhNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIG 438
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 523588760 536 IPKADLAKIFERFYrvdkarSRKLGGTGLGLAIAKEVVLAHGGTIWAESKEHKGTTIYFTLPL 598
Cdd:COG5805 439 IPEERLKKLGEPFF------TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPL 495
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
274-598 |
4.41e-42 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 155.73 E-value: 4.41e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 274 DGVIATDRRGRVILINDAALNILNVSRETVLSSSIVDVLGIADQYTFETLLEERDSLILDFSTDEELYILRASLSVIQKE 353
Cdd:COG4191 26 LLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLAALDAEE 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 354 ggfVNGLIVVLHDITEQEKIDRERR----------------QFVANVSHELRTPLTTMKSYLEALAD--GAWQDKDIAPR 415
Cdd:COG4191 106 ---NAELEELERDITELERAEEELRelqeqlvqseklaalgELAAGIAHEINNPLAAILGNAELLRRrlEDEPDPEELRE 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 416 FIQVVQNETERMIRLVNDLLHLSKLDSkdykLKKTWINFSAYFHKVIDRFELT-KSDNIRFVRKIPREAIFIEVDEDKIT 494
Cdd:COG4191 183 ALERILEGAERAAEIVRSLRAFSRRDE----EEREPVDLNELIDEALELLRPRlKARGIEVELDLPPDLPPVLGDPGQLE 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 495 QVLDNIISNALK--YSPQGGTITFRVRKLSDEMIVSVSDEGVGIPKADLAKIFERFY---RVDKarsrklgGTGLGLAIA 569
Cdd:COG4191 259 QVLLNLLINAIDamEEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFttkPVGK-------GTGLGLSIS 331
|
330 340
....*....|....*....|....*....
gi 523588760 570 KEVVLAHGGTIWAESKEHKGTTIYFTLPL 598
Cdd:COG4191 332 YGIVEKHGGRIEVESEPGGGTTFTITLPL 360
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
8-600 |
4.65e-42 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 158.65 E-value: 4.65e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 8 RSIHFKFVIIYVLLILVAMQIIGVYFVRKLETELVQNFKNSLNERVTLLAYNVEQAMN----RERDEKSPTLEEDIRSLL 83
Cdd:NF040691 3 RSLQLRVVAITLLLSLVVILVLGVVLALQITNGLLDNRVDAALGDSRRARTQAQSQLNasdaSTSDSAQQLLRTTLLSVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 84 HDFVSQDISEVRVidekgkVLAtSNPYMQNIVGKRTTEIYVKRSLVTGEIVDRmlLDSKTGHRMYISSTPIKTSG-EIKG 162
Cdd:NF040691 83 ASASGAMQGAFDV------VLL-VPGDDPSGLGPRASGSVGLVSQIPEELREA--VAGGQVAQQYQSVALPSGDGsSAPA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 163 VI---------------YVIASMENVFSQMRQINMILATGtGIALAITAVLGIFL-SRTITRPISDMRRQALAMTRGDFS 226
Cdd:NF040691 154 LVvgtpvtlpvagnyelYLLFPLEDEQSTLALVRGTLLLG-GLALVVLLGLIAWLvTRQVVAPVRSAARTAERFAAGDLS 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 227 RKVKVYGYDEIGQLAMTFNNLTKKLQeaqattegerrklesvlthmtdgviatdrrgrvilindaalnilnvsretvlss 306
Cdd:NF040691 233 ERMPVKGEDDLARLARSFNQMADSLQ------------------------------------------------------ 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 307 sivdvlgiadqytfetlleerdslildfstdeelyilraslsviqkeggfvnglivvlHDITEQEKIDRERRQFVANVSH 386
Cdd:NF040691 259 ----------------------------------------------------------RQIRQLEELSRLQQRFVSDVSH 280
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 387 ELRTPLTTMKSYLEALADgawQDKDIAP---RFIQVVQNETERMIRLVNDLLHLSKLDSKDYKLKKTWINFSAYFHKVID 463
Cdd:NF040691 281 ELRTPLTTIRMAADVIHD---SRDDFDPataRSAELLHTELDRFESLLSDLLEISRFDAGAAELDVEPVDLRPLVRRVVD 357
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 464 RFE-LTKSDNIRFVRKIPREAIFIEVDEDKITQVLDNIISNALKYSpQGGTITFRVRKLSDEMIVSVSDEGVGIPKADLA 542
Cdd:NF040691 358 ALRqLAERAGVELRVDAPGTPVVAEVDPRRVERVLRNLVVNAIEHG-EGKPVVVTVAQDDTAVAVTVRDHGVGLKPGEVA 436
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*...
gi 523588760 543 KIFERFYRVDKARSRKLGGTGLGLAIAKEVVLAHGGTIWAESKEHKGTTIYFTLPLER 600
Cdd:NF040691 437 LVFDRFWRADPARARTTGGTGLGLAIALEDARLHGGWLEAWGRPGQGSQFRLTLPRVA 494
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
379-597 |
7.21e-42 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 157.16 E-value: 7.21e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 379 QFVANVSHELRTPLTTMKSYLE-ALAdgawQDKDiAPRFIQVVQN---ETERMIRLVNDLLHLSKLDSKDYKLKKTWINF 454
Cdd:TIGR01386 243 QFSADLAHELRTPLTNLLGQTQvALS----QPRT-GEEYREVLESnleELERLSRMVSDMLFLARADNGQLALERVRLDL 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 455 SAYFHKVIDRFELTKSDniRFVRKIPREAIFIEVDEDKITQVLDNIISNALKYSPQGGTITFRVRKLSDEMIVSVSDEGV 534
Cdd:TIGR01386 318 AAELAKVAEYFEPLAEE--RGVRIRVEGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGP 395
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 523588760 535 GIPKADLAKIFERFYRVDKARSRKLGGTGLGLAIAKEVVLAHGGTIWAESKEHKgTTIYFTLP 597
Cdd:TIGR01386 396 GIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDGK-TRFILRFP 457
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
371-601 |
1.57e-41 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 156.33 E-value: 1.57e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 371 EKIDRERRQFVANVSHELRTPLTTMKSYLEALADGAWQdkdIAPRFIQVVQNETERMIRLVNDLLHLSKLDSKDYKLKKT 450
Cdd:PRK10549 234 EKNEQMRRDFMADISHELRTPLAVLRGELEAIQDGVRK---FTPESVASLQAEVGTLTKLVDDLHQLSLSDEGALAYRKT 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 451 WINFSAYFHKVIDRF-ELTKSDNIRFVRKIPREAIFIEvDEDKITQVLDNIISNALKYSPQGGTITFRVRKLSDEMIVSV 529
Cdd:PRK10549 311 PVDLVPLLEVAGGAFrERFASRGLTLQLSLPDSATVFG-DPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTF 389
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 523588760 530 SDEGVGIPKADLAKIFERFYRVDKARSRKLGGTGLGLAIAKEVVLAHGGTIWAESKEHKGTTIYFTLPLERE 601
Cdd:PRK10549 390 ADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERD 461
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
489-599 |
7.86e-41 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 143.94 E-value: 7.86e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 489 DEDKITQVLDNIISNALKYSPQGGTITFRVRKLSDEMIVSVSDEGVGIPKADLAKIFERFYRVDKaRSRKLGGTGLGLAI 568
Cdd:smart00387 2 DPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLSI 80
|
90 100 110
....*....|....*....|....*....|.
gi 523588760 569 AKEVVLAHGGTIWAESKEHKGTTIYFTLPLE 599
Cdd:smart00387 81 VKKLVELHGGEISVESEPGGGTTFTITLPLE 111
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
493-596 |
3.67e-40 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 141.59 E-value: 3.67e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 493 ITQVLDNIISNALKYSPQGGTITFRVRKLSDEMIVSVSDEGVGIPKADLAKIFERFYRVDKarSRKLGGTGLGLAIAKEV 572
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDK--SREGGGTGLGLAIVRRI 78
|
90 100
....*....|....*....|....
gi 523588760 573 VLAHGGTIWAESKEHKGTTIYFTL 596
Cdd:cd00075 79 VEAHGGRITVESEPGGGTTFTVTL 102
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
371-597 |
8.92e-40 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 151.52 E-value: 8.92e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 371 EKIDRERRQFVANVSHELRTPLTTMKSYLEALADGAwqdKDIAPRFIQVVQNETERMIRLVNDLLHLSKLDSKDYKLKKT 450
Cdd:NF012163 234 EKNEQMRRDFMADISHELRTPLAVLRAELEAIQDGI---RKFTPESLDSLQAEVGTLTKLVDDLHDLSMSDEGALAYQKA 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 451 WINFSAYFHKVIDRF-ELTKSDNIRFVRKIPrEAIFIEVDEDKITQVLDNIISNALKYSPQGGTITFRVRKLSDEMIVSV 529
Cdd:NF012163 311 SVDLVPLLEVEGGAFrERFASAGLELEVSLP-DSSLVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISASQRPKEVTLTV 389
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 523588760 530 SDEGVGIPKADLAKIFERFYRVDKARSRKLGGTGLGLAIAKEVVLAHGGTIWAESKEHKGTTIYFTLP 597
Cdd:NF012163 390 ADSAPGVSDEQLARLFERFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTLHAAHSPLGGLRIVVTLP 457
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
370-600 |
1.95e-38 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 145.86 E-value: 1.95e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 370 QEKID-RERRQF----VANVSHELRTPLTTMKSYLEALADGAWQDKDIAP-----RFIQVVQNETERMIRLVNDLLHLSK 439
Cdd:PRK09303 139 QENETlLEQLKFkdrvLAMLAHDLRTPLTAASLALETLELGQIDEDTELKpalieQLQDQARRQLEEIERLITDLLEVGR 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 440 LDSKDYKLKKTWINFSAYFHKVIDRFE-LTKSDNIRFVRKIPREAIFIEVDEDKITQVLDNIISNALKYSPQGGTITFRV 518
Cdd:PRK09303 219 TRWEALRFNPQKLDLGSLCQEVILELEkRWLAKSLEIQTDIPSDLPSVYADQERIRQVLLNLLDNAIKYTPEGGTITLSM 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 519 -RKLSDEMIVSVSDEGVGIPKADLAKIFERFYRVDkaRSRKLGGTGLGLAIAKEVVLAHGGTIWAESKEHKGTTIYFTLP 597
Cdd:PRK09303 299 lHRTTQKVQVSICDTGPGIPEEEQERIFEDRVRLP--RDEGTEGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTLP 376
|
...
gi 523588760 598 LER 600
Cdd:PRK09303 377 VYR 379
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
495-598 |
5.36e-36 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 130.69 E-value: 5.36e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 495 QVLDNIISNALKYSPQGgTITFRVRKLSDEM-----IVSVSDEGVGIPKADLAKIFERFYRVDKARSRKLGGTGLGLAIA 569
Cdd:cd16922 3 QILLNLLGNAIKFTEEG-EVTLRVSLEEEEEdgvqlRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAIS 81
|
90 100
....*....|....*....|....*....
gi 523588760 570 KEVVLAHGGTIWAESKEHKGTTIYFTLPL 598
Cdd:cd16922 82 KKLVELMGGDISVESEPGQGSTFTFTLPL 110
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
489-600 |
1.69e-35 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 129.03 E-value: 1.69e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 489 DEDKITQVLDNIISNALKYSPQGGTITFRVRKlSDEMIVSVSDEGVGIPKADLAKIFERFYRVDKarsRKLGGTGLGLAI 568
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAGEITVTLSE-GGELTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGLSI 77
|
90 100 110
....*....|....*....|....*....|..
gi 523588760 569 AKEVVLAHGGTIWAESKEHKGTTIYFTLPLER 600
Cdd:pfam02518 78 VRKLVELLGGTITVESEPGGGTTVTLTLPLAQ 109
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
369-603 |
1.16e-33 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 137.22 E-value: 1.16e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 369 EQEKIDRERRQFVANVSHELRTPLTTMKSYLEALadgawQDKDIAP---RFIQVVQNETERMIRLVNDLLHLSKLDSKDY 445
Cdd:TIGR02956 456 EAEEANRAKSAFLATMSHEIRTPLNGILGTLELL-----GDTGLTSqqqQYLQVINRSGESLLDILNDILDYSKIEAGHL 530
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 446 KLKKTWINFSAYFHKVIDRFE---LTKSDNIRFVRKIPREAiFIEVDEDKITQVLDNIISNALKYSPQgGTITFRVRkLS 522
Cdd:TIGR02956 531 SISPRPFDLNALLDDVHHLMVsraQLKGIQLRLNIPEQLPN-WWQGDGPRIRQVLINLVGNAIKFTDR-GSVVLRVS-LN 607
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 523 DEMIV--SVSDEGVGIPKADLAKIFERFYRVDKarSRKLGGTGLGLAIAKEVVLAHGGTIWAESKEHKGTTIYFTLPLER 600
Cdd:TIGR02956 608 DDSSLlfEVEDTGCGIAEEEQATLFDAFTQADG--RRRSGGTGLGLAISQRLVEAMDGELGVESELGVGSCFWFTLPLTR 685
|
...
gi 523588760 601 EQK 603
Cdd:TIGR02956 686 GKP 688
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
378-597 |
1.25e-33 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 134.13 E-value: 1.25e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 378 RQ--FVANVSHELRTPLTTMKSYLE-ALADGAWQD--KDIaprfIQVVQNETERMIRLVNDLLHLSKLDSKDYKLKKTWI 452
Cdd:PRK09835 261 RQsnFSADIAHEIRTPITNLITQTEiALSQSRSQKelEDV----LYSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKML 336
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 453 NFSAYFHKVIDRFELTKSD---NIRFVRKIPReaifIEVDEDKITQVLDNIISNALKYSPQGGTITFRVRKLSDEMIVSV 529
Cdd:PRK09835 337 DLADEVGKVFDFFEAWAEErgvELRFVGDPCQ----VAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVV 412
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 523588760 530 SDEGVGIPKADLAKIFERFYRVDKARSRKLGGTGLGLAIAKEVVLAHGGTIWAESkEHKGTTIYFTLP 597
Cdd:PRK09835 413 ENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTS-DARGTRFVISLP 479
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
368-599 |
4.51e-33 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 135.55 E-value: 4.51e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 368 TEQEKIDRERRQ----FVANVSHELRTPLTTMKSYLEALA-DGAWQDKDIAPRFIQVVQnETERMIRLVNDLLHLSKLDS 442
Cdd:PRK10490 651 EEQARLASEREQlrnaLLAALSHDLRTPLTVLFGQAEILTlDLASEGSPHARQASEIRQ-QVLNTTRLVNNLLDMARIQS 729
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 443 KDYKLKKTWINFSAYFHKVIDRFELTKSDN-IRFvrKIPREAIFIEVDEDKITQVLDNIISNALKYSPQGGTITFRVRKL 521
Cdd:PRK10490 730 GGFNLRKEWLTLEEVVGSALQMLEPGLSGHpINL--SLPEPLTLIHVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVE 807
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 523588760 522 SDEMIVSVSDEGVGIPKADLAKIFERFYRVDKARSrkLGGTGLGLAIAKEVVLAHGGTIWAESKEHKGTTIYFTLPLE 599
Cdd:PRK10490 808 GERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESA--IPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLPLE 883
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
379-598 |
7.49e-32 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 128.81 E-value: 7.49e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 379 QFVANVSHELRTPLTTMKSYLEALADGAwqDKDIAPRFIQVVQNETERMIRLVNDLLHLSKLDSKDYKLKKTWINFSAYF 458
Cdd:PRK11100 258 QYVQTLTHELKSPLAAIRGAAELLQEDP--PPEDRARFTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALL 335
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 459 HKVIDRFEltksdnIRFVRK-----IPREAIFIEVDEDKITQVLDNIISNALKYSPQGGTITFRVRKLSDEMIVSVSDEG 533
Cdd:PRK11100 336 EELVEARE------AQAAAKgitlrLRPDDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQG 409
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 523588760 534 VGIPKADLAKIFERFY---RVDKARSrklgGTGLGLAIAKEVVLAHGGTIWAESKEHKGTTIYFTLPL 598
Cdd:PRK11100 410 PGIPDYALPRIFERFYslpRPANGRK----STGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPR 473
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
382-580 |
1.70e-31 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 125.49 E-value: 1.70e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 382 ANVSHELRTPLTTMKSYLEALADGAWQDKdiaPRFIQVVQNETERMIRLVNDLLHLSKLDSKDYKLKKTWINFSAYFHKV 461
Cdd:NF012226 143 AAIAHELRTPITILQGRLQGILDGVFEPD---PALFKSLLNQVEGLSHLVEDLRTLSLVENQQLRLNYESVDLKDSIEKV 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 462 I----DRFELTksdNIRFVRKIPREAIFieVDEDKITQVLDNIISNALKYSpQGGTITFRVRKLSDEMIVSVSDEGVGIP 537
Cdd:NF012226 220 LkmfeDRLEQA---QLTIVLNLTATPVF--CDRRRIEQVLIALIDNAIRYA-NAGKLKISSSVIQDDWILQIEDEGPGIA 293
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 523588760 538 KADLAKIFERFYRVDKARSRKLGGTGLGLAIAKEVVLAHGGTI 580
Cdd:NF012226 294 EEYQQDLFNPFFRLEQSRNKEFGGTGLGLAVVHAIVIAHKGSI 336
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
381-601 |
1.07e-30 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 125.43 E-value: 1.07e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 381 VANVSHELRTPLTTMKsyleaLADGAWQDKDIAPRFIQVVQNETERMIRLVNDLLHLSKLDSKDYKLKKTwinFSAY--F 458
Cdd:PRK09470 247 LSDISHELRTPLTRLQ-----LATALLRRRQGESKELERIETEAQRLDSMINDLLVLSRNQQKNHLERET---FKANslW 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 459 HKVID--RFELTKSdNIRFVRKIPREAIFIEVDEDKITQVLDNIISNALKYSPQGGTITFRVRKlsDEMIVSVSDEGVGI 536
Cdd:PRK09470 319 SEVLEdaKFEAEQM-GKSLTVSAPPGPWPINGNPNALASALENIVRNALRYSHTKIEVAFSVDK--DGLTITVDDDGPGV 395
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 523588760 537 PKADLAKIFERFYRVDKARSRKLGGTGLGLAIAKEVVLAHGGTIWAESKEHKGTTIYFTLPLERE 601
Cdd:PRK09470 396 PEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLPLYKR 460
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
489-597 |
1.27e-30 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 115.64 E-value: 1.27e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 489 DEDKITQVLDNIISNALKYSPQGGTITFRVRKLSDEMIVSVSDEGVGIPKADLAKIFERFYRVDKARSRKLGGTGLGLAI 568
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 523588760 569 AKEVVLAHGGTIWAESKEHKGTTIYFTLP 597
Cdd:cd16946 81 CHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-598 |
3.32e-30 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 114.35 E-value: 3.32e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 493 ITQVLDNIISNALKYSPQggTITFRVRKLSDEMIVSVSDEGVGIPKADLAKIFERFYRVDKARSRKLGGTGLGLAIAKEV 572
Cdd:cd16949 1 LARALENVLRNALRYSPS--KILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERA 78
|
90 100
....*....|....*....|....*.
gi 523588760 573 VLAHGGTIWAESKEHKGTTIYFTLPL 598
Cdd:cd16949 79 IEQHGGKIKASNRKPGGLRVRIWLPA 104
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
382-605 |
5.29e-29 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 120.28 E-value: 5.29e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 382 ANVSHELRTPLTTMK---SYLEALADGAWQDKDIAprfiQVVQNETERMIRLVNDLLHLSKldSKDYKLKKTWIN-FSAY 457
Cdd:PRK10364 242 AGVAHEIRNPLSSIKglaKYFAERAPAGGEAHQLA----QVMAKEADRLNRVVSELLELVK--PTHLALQAVDLNdLINH 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 458 FHKVIDRFELTKSDNIRFVrkiPREAI-FIEVDEDKITQVLDNIISNALKYSPQGGTITFRVRKLSDEMIVSVSDEGVGI 536
Cdd:PRK10364 316 SLQLVSQDANSREIQLRFT---ANDTLpEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGI 392
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 523588760 537 PKADLAKIFERFYrvdkarSRKLGGTGLGLAIAKEVVLAHGGTIWAESKEHKGTTIYFTLPLEREQKDD 605
Cdd:PRK10364 393 AADQLEAIFTPYF------TTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVNITRRDP 455
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
377-598 |
2.69e-27 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 114.70 E-value: 2.69e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 377 RRQFVANVSHELRTPLTTMKSYLEALadgawqdKDIAPRFIQVVQNETERMIRLVNDLLHLSKLDSKDYKLKKTWINFSA 456
Cdd:PRK10604 212 KKQLIDGIAHELRTPLVRLRYRLEMS-------DNLSAAESQALNRDIGQLEALIEELLTYARLDRPQNELHLSEPDLPA 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 457 YFHKVIDRFELTKSDnIRFVRKIPREAIFIEVDEDKITQVLDNIISNALKYSPQGGTITFRVRKlsDEMIVSVSDEGVGI 536
Cdd:PRK10604 285 WLSTHLADIQAVTPE-KTVRLDTPHQGDYGALDMRLMERVLDNLLNNALRYAHSRVRVSLLLDG--NQACLIVEDDGPGI 361
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 523588760 537 PKADLAKIFERFYRVDKARSRKLGGTGLGLAIAKEVVLAHGGTIWAESKEHKGTTIYFTLPL 598
Cdd:PRK10604 362 PPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWPV 423
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
237-601 |
6.00e-26 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 110.32 E-value: 6.00e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 237 IGQLAMTFNNLTKKLQEAQATTEGERRKLESVLTHMTDGVIATDRRGRVILINDAALNILNVSRETVLSSSIVDVLGIAD 316
Cdd:COG3290 58 LILLLLLLLLLAALLLKLLEEIARLVEEREAVLESIREGVIAVDRDGRITLINDAARRLLGLDAIGRPIDEVLAEVLETG 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 317 QYTFETLLEERdslildfstdeelyILRASLSVIQKEGGFVnGLIVVLHDITEQEKIDRE-----------RRQfvanvS 385
Cdd:COG3290 138 ERDEEILLNGR--------------VLVVNRVPIRDDGRVV-GAVATFRDRTELERLEEElegvkelaealRAQ-----R 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 386 HELRTPLTTMKSYLEALADgawqdkDIAPRFIQVVQNETERMIRLVNDLLHLSKLDSkdykLkktwinfsayfhkVIDRF 465
Cdd:COG3290 198 HDFRNHLHTISGLLQLGEY------DEALEYIDEISEELQELIDSLLSRIGNPVLAA----L-------------LLGKA 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 466 ELTKSDNIRFVRKIPREAIFIEVDEDKITQVLDNIISNAL----KYSPQGGTITFRVRKLSDEMIVSVSDEGVGIPKADL 541
Cdd:COG3290 255 ARARERGIDLTIDIDSDLPDLPLSDTDLVTILGNLLDNAIeaveKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELL 334
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 523588760 542 AKIFERFYrvdkarSRKLG-GTGLGLAIAKEVVLAHGGTIWAESKEHKGTTIYFTLPLERE 601
Cdd:COG3290 335 EKIFERGF------STKLGeGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEGE 389
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
499-597 |
2.97e-25 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 100.35 E-value: 2.97e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 499 NIISNALKYSPQGGTITFRVRKLSDEMIVSVSDEGVGIPKADLAKIFERFYRVDKARSRKLGGTGLGLAIAKEVVLAHGG 578
Cdd:cd16952 7 NLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVMSRHDA 86
|
90
....*....|....*....
gi 523588760 579 TIWAESKEHKGTTIYFTLP 597
Cdd:cd16952 87 RLLIASELGKGSRFTCLFP 105
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
379-598 |
4.95e-24 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 104.95 E-value: 4.95e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 379 QFVANVSHELRTPLTTMKSYLEALadgawQDKDIAP----RFIQVVQNETERMIRLVNDLLHLSKLDSKdyklKKTWINF 454
Cdd:COG5806 203 ELAASIAHEVRNPLTVVRGFIQLL-----QEPELSDekrkQYIRIALEELDRAEAIITDYLTFAKPQPE----KLEKIDV 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 455 SAYFHKVIDRFE-LTKSDNIRfVRKIPREAIFIEVDEDKITQVLDNIISNALKYSPQGGTITFRVRKLSDEMIVSVSDEG 533
Cdd:COG5806 274 SEELEHVIDVLSpYANMNNVE-IQTELEPGLYIEGDRQKLQQCLINIIKNGIEAMPNGGTLTIDVSIDKNKVIISIKDTG 352
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 523588760 534 VGIPKADLAKIFERFYrvdkarSRKLGGTGLGLAIAKEVVLAHGGTIWAESKEHKGTTIYFTLPL 598
Cdd:COG5806 353 VGMTKEQLERLGEPYF------STKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITLPL 411
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
489-580 |
5.74e-24 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 96.79 E-value: 5.74e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 489 DEDKITQVLDNIISNALKYSPQGGTITFRVRKL-SDEMIVSVSDEGVGIPKADLAKIFERFYRVDKARSRKLGGTGLGLA 567
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFrLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80
|
90
....*....|...
gi 523588760 568 IAKEVVLAHGGTI 580
Cdd:cd16925 81 IVKEFVELHGGTV 93
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
359-598 |
2.45e-23 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 105.02 E-value: 2.45e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 359 GLIVVLHDITEQ-------EKIDRERRQFVANVSHELRTPLTTMKSYLEALAD---GAWQDKdiaprFIQVVQNETERMI 428
Cdd:PRK11091 258 GLMGFGRDITERkryqdalEKASRDKTTFISTISHELRTPLNGIVGLSRILLDtelTAEQRK-----YLKTIHVSAITLG 332
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 429 RLVNDLLHLSKLDSKDYKLKKTWINFSAYfhkvIDRFE-----LTKSDNIRFVRKiPREA--IFIEVDEDKITQVLDNII 501
Cdd:PRK11091 333 NIFNDIIDMDKMERRKLQLDNQPIDFTDF----LADLEnlsglQAEQKGLRFDLE-PLLPlpHKVITDGTRLRQILWNLI 407
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 502 SNALKYSPQGGtITFRV-RKLSDEMIVSVSDEGVGIPKADLAKIFERFYRV-DKARSRKLGGTGLGLAIAKEVVLAHGGT 579
Cdd:PRK11091 408 SNAVKFTQQGG-VTVRVrYEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVkDSHGGKPATGTGIGLAVSKRLAQAMGGD 486
|
250
....*....|....*....
gi 523588760 580 IWAESKEHKGTTIYFTLPL 598
Cdd:PRK11091 487 ITVTSEEGKGSCFTLTIHA 505
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-597 |
4.32e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 93.93 E-value: 4.32e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 493 ITQVLDNIISNALKYSPQGGT--ITFRVRKLSDEMIVSVSDEGVGIPKADLAKIFERFYRVDKarSRKLGGTGLGLAIAK 570
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPprIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHS--REEYEGTGVGLAIVR 78
|
90 100
....*....|....*....|....*..
gi 523588760 571 EVVLAHGGTIWAESKEHKGTTIYFTLP 597
Cdd:cd16921 79 KIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
377-603 |
6.04e-23 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 104.05 E-value: 6.04e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 377 RRQFVANVSHELRTPLTTMKSYLEALAdGAWQDKDIAPRFIQVVQNETERMIRLVNDLLHLSKLDSKDYKLKKTWINFSA 456
Cdd:PRK09959 712 KSQFLATMSHEIRTPISSIMGFLELLS-GSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWVDIPT 790
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 457 YFHKVIDRF---ELTKSDNIRFVRKIPrEAIFIEVDEDKITQVLDNIISNALKYSPQGGT-ITFRVRKLSDEMIV---SV 529
Cdd:PRK09959 791 LVQNTCHSFgaiAASKSIALSCSSTFP-DHYLVKIDPQAFKQVLSNLLSNALKFTTEGAVkITTSLGHIDDNHAVikmTI 869
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 523588760 530 SDEGVGIPKADLAKIFERFYRVDKARSRKlgGTGLGLAIAKEVVLAHGGTIWAESKEHKGTTIYFTLPLEREQK 603
Cdd:PRK09959 870 MDSGSGLSQEEQQQLFKRYSQTSAGRQQT--GSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPVEISQQ 941
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
380-599 |
5.95e-22 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 100.69 E-value: 5.95e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 380 FVANVSHELRTPLT--------TMKSYLEAladgAWQDkdiaprFIQVVQNETERMIRLVNDLLHLSKLDSKdyKLKKTW 451
Cdd:PRK11107 296 FLANMSHELRTPLNgvigftrqTLKTPLTP----TQRD------YLQTIERSANNLLAIINDILDFSKLEAG--KLVLEN 363
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 452 INFSayFHKVIDR-------------FELT-KSDNirfvrKIPREAIFievDEDKITQVLDNIISNALKYSPQGgTITFR 517
Cdd:PRK11107 364 IPFS--LRETLDEvvtllahsahekgLELTlNIDP-----DVPDNVIG---DPLRLQQIITNLVGNAIKFTESG-NIDIL 432
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 518 V--RKLSDEMI---VSVSDEGVGIPKADLAKIFERFYRVDKARSRKLGGTGLGLAIAKEVVLAHGGTIWAESKEHKGTTI 592
Cdd:PRK11107 433 VelRALSNTKVqleVQIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQKLVNEMGGDISFHSQPNRGSTF 512
|
....*..
gi 523588760 593 YFTLPLE 599
Cdd:PRK11107 513 WFHLPLD 519
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
496-598 |
1.88e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 89.41 E-value: 1.88e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 496 VLDNIISNALKYSPQGGTITFRVRklSDEMIVSVSDEGVGIPKADLAKIFERFYRVDKARSRKLGGTGLGLAIAKEVVLA 575
Cdd:cd16939 4 ALDNLLRNALRYAHRTVRIALLVS--GGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVALW 81
|
90 100
....*....|....*....|...
gi 523588760 576 HGGTIWAESKEHKGTTIYFTLPL 598
Cdd:cd16939 82 HGGHVECDDSELGGACFRLTWPR 104
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
496-597 |
3.47e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 88.88 E-value: 3.47e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 496 VLDNIISNALKYSPQGGTITFRVRKLSDEMIVSVSDEGVGIPKADLAKIFERFYRVDKARsRKLGGTGLGLAIAKEVVLA 575
Cdd:cd16948 9 IIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGR-NFQESTGMGLYLVKKLCDK 87
|
90 100
....*....|....*....|..
gi 523588760 576 HGGTIWAESKEHKGTTIYFTLP 597
Cdd:cd16948 88 LGHKIDVESEVGEGTTFTITFP 109
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
369-600 |
3.63e-21 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 98.44 E-value: 3.63e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 369 EQEKIDRERRQFVANVSHELRTPLTTMKSYLEALADgawqdKDIAPR---FIQVVQNETERMIRLVNDLLHLSKLDSKDY 445
Cdd:PRK11466 436 EAEKASQAKSAFLAAMSHEIRTPLYGILGTAQLLAD-----NPALNAqrdDLRAITDSGESLLTILNDILDYSAIEAGGK 510
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 446 KLKKTWINFS------AYFHKVIDRFeltKSDNIRFVRKIPRE-AIFIEVDEDKITQVLDNIISNALKYSPQGgTITFRV 518
Cdd:PRK11466 511 NVSVSDEPFEprplleSTLQLMSGRV---KGRPIRLATDIADDlPTALMGDPRRIRQVITNLLSNALRFTDEG-SIVLRS 586
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 519 RKLSDEMIVSVSDEGVGIPKADLAKIFERFYRVdkarSRKLGGTGLGLAIAKEVVLAHGGTIWAESKEHKGTTIYFTLPL 598
Cdd:PRK11466 587 RTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQV----SGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPL 662
|
..
gi 523588760 599 ER 600
Cdd:PRK11466 663 RV 664
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
496-597 |
4.04e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 88.60 E-value: 4.04e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 496 VLDNIISNALKYSPQGGTITFRVRKLSDEMIVSVSDEGVGIPKADLAKIFERFYRVDKarSRKLGGTGLGLAIAKEVVLA 575
Cdd:cd16923 4 VFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDN--SRNTEGAGLGLSIAKAIIEL 81
|
90 100
....*....|....*....|..
gi 523588760 576 HGGTIWAESkEHKGTTIYFTLP 597
Cdd:cd16923 82 HGGSASAEY-DDNHDLFKVRLP 102
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
489-592 |
1.13e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 87.46 E-value: 1.13e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 489 DEDKITQVLDNIISNALKYSPQGGTITFRVRKlSDEMIVSVSDEGVGIPKADLAKIFERFYRVDKarsRKLGGTGLGLAI 568
Cdd:cd16940 10 DALLLFLLLRNLVDNAVRYSPQGSRVEIKLSA-DDGAVIRVEDNGPGIDEEELEALFERFYRSDG---QNYGGSGLGLSI 85
|
90 100
....*....|....*....|....
gi 523588760 569 AKEVVLAHGGTIWAESKEHKGTTI 592
Cdd:cd16940 86 VKRIVELHGGQIFLGNAQGGGLEA 109
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
369-599 |
1.46e-20 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 96.25 E-value: 1.46e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 369 EQEKIDRERRQFVANVSHELRTPLTTMKSYLEALADGAWQDKDIapRFIQVVQNETERMIRLVNDLLHLSKLDSKDYKLK 448
Cdd:PRK15347 390 RAEQANKRKSEHLTTISHEIRTPLNGVLGALELLQNTPLTAEQM--DLADTARQCTLSLLAIINNLLDFSRIESGQMTLS 467
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 449 ktwINFSAYFhKVIDRFELT-------KSDNIR-FVRK-IPREAifiEVDEDKITQVLDNIISNALKYSPQGGtITFRVR 519
Cdd:PRK15347 468 ---LEETALL-PLLDQAMLTiqgpaqsKSLTLRtFVGAhVPLYL---HLDSLRLRQILVNLLGNAVKFTETGG-IRLRVK 539
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 520 KLSDEMIVSVSDEGVGIPKADLAKIFERFYRVDKarsrKLGGTGLGLAIAKEVVLAHGGTIWAESKEHKGTTIYFTLPLE 599
Cdd:PRK15347 540 RHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADT----HSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLPLN 615
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-597 |
4.92e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 85.53 E-value: 4.92e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 493 ITQVLDNIISNALKYSPQGG------TITFrVRKLSDEMIVSVSDEGVGIPKADLAKIFERFYrvdkarSRKLGGTGLGL 566
Cdd:cd16920 1 IQQVLINLVRNGIEAMSEGGcerrelTIRT-SPADDRAVTISVKDTGPGIAEEVAGQLFDPFY------TTKSEGLGMGL 73
|
90 100 110
....*....|....*....|....*....|.
gi 523588760 567 AIAKEVVLAHGGTIWAESKEHKGTTIYFTLP 597
Cdd:cd16920 74 SICRSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
479-596 |
9.52e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 85.26 E-value: 9.52e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 479 IPREAIFIEVDEDKITQVLDNIISNALKYSPQGGTITFRVRKLSDEMIVSVSDEGVGIPKADLAKIFERFYRVDKARSRK 558
Cdd:cd16947 7 IPDRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSA 86
|
90 100 110
....*....|....*....|....*....|....*...
gi 523588760 559 LGGTGLGLAIAKEVVLAHGGTIWAESKEHKGTTIYFTL 596
Cdd:cd16947 87 KQGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-598 |
2.95e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 83.24 E-value: 2.95e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 493 ITQVLDNIISNALKYSPQGGTITFRVRKLSDEMIVSVSDEGVGIPKADLAKIFERFYrvdkaRSRKLG-GTGLGLAIAKE 571
Cdd:cd16943 4 LNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFF-----TTKPVGeGTGLGLSLSYR 78
|
90 100
....*....|....*....|....*..
gi 523588760 572 VVLAHGGTIWAESKEHKGTTIYFTLPL 598
Cdd:cd16943 79 IIQKHGGTIRVASVPGGGTRFTIILPI 105
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
495-592 |
2.67e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 80.69 E-value: 2.67e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 495 QVLDNIISNALKYSP-QGGTITFRVRKLSDEMIVSVSDEGVGIPKADLAKIFERFYrVDKARSRKLG-GTGLGLAIAKEV 572
Cdd:cd16953 3 QVLRNLIGNAISFSPpDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFY-TERPANEAFGqHSGLGLSISRQI 81
|
90 100
....*....|....*....|
gi 523588760 573 VLAHGGTIWAESKEHKGTTI 592
Cdd:cd16953 82 IEAHGGISVAENHNQPGQVI 101
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
489-594 |
4.36e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 79.81 E-value: 4.36e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 489 DEDKITQVLDNIISNALKYSPQGGTITFRVRKLSDEMIVSVSDEGVGIPKADLAKIFERFYRVDKARSRKlGGTGLGLAI 568
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSG-GHYGMGLYI 79
|
90 100
....*....|....*....|....*.
gi 523588760 569 AKEVVLAHGGTIWAESKEHKGTTIYF 594
Cdd:cd16975 80 AKNLVEKHGGSLIIENSQKGGAEVTV 105
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
370-578 |
5.41e-18 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 85.79 E-value: 5.41e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 370 QEKIDRERrQFVANVSHELRTPLTTMKSYLEALADGAWQDkdiaprfIQVVQNETERMIRLVNDLLHLS----KLDSKDY 445
Cdd:PRK10755 131 TSTLDQER-LFTADVAHELRTPLAGIRLHLELLEKQHHID-------VAPLIARLDQMMHTVEQLLQLAragqSFSSGHY 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 446 KLKKtWINfsayfhKVID--RFELTKSDNIRFVR-KIPREAIFIEVDEDKI--TQVLDNIISNALKYSPQGGTITFRVRK 520
Cdd:PRK10755 203 QTVK-LLE------DVILpsQDELSEMLEQRQQTlLLPESAADITVQGDATllRLLLRNLVENAHRYSPEGSTITIKLSQ 275
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 523588760 521 LSDEMIVSVSDEGVGIPKADLAKIFERFYRVDkarsRKLGGTGLGLAIAKEVVLAHGG 578
Cdd:PRK10755 276 EDGGAVLAVEDEGPGIDESKCGELSKAFVRMD----SRYGGIGLGLSIVSRITQLHHG 329
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
495-580 |
6.32e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 79.43 E-value: 6.32e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 495 QVLDNIISNALKYSPQGGTITFRVRKLSDEMIVSVSDEGVGIPKADLAKIFERFYRVDKARSRKlGGTGLGLAIAKEVVL 574
Cdd:cd16945 7 QAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQ-KSTGLGLAFVQEVAQ 85
|
....*.
gi 523588760 575 AHGGTI 580
Cdd:cd16945 86 LHGGRI 91
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
376-442 |
6.98e-18 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 78.02 E-value: 6.98e-18
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 523588760 376 ERRQFVANVSHELRTPLTTMKSYLEALADgaWQDKDIAPRFIQVVQNETERMIRLVNDLLHLSKLDS 442
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRD--EKLDEEQREYLETILRSAERLLRLINDLLDLSRIEA 65
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
378-597 |
1.02e-17 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 87.11 E-value: 1.02e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 378 RQFVANVSHELRTPLTTMKSYLEALADGawQDKDIAPRFIQVVQNETERMIRLVNDLLHLSKLDSKDYKLKKTWINFSAY 457
Cdd:TIGR03785 486 ENMSSRLSHELRTPVAVVRSSLENLELQ--ALEQEKQKYLERAREGTERLSMILNNMSEATRLEQAIQSAEVEDFDLSEV 563
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 458 FHKVIDRFELTKSdNIRFVRKIPREAIFIEVDEDKITQVLDNIISNALKYSPQGGTITFRVRKLSDEMIVSVSDEGVGIP 537
Cdd:TIGR03785 564 LSGCMQGYQMTYP-PQRFELNIPETPLVMRGSPELIAQMLDKLVDNAREFSPEDGLIEVGLSQNKSHALLTVSNEGPPLP 642
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 523588760 538 KADLAKIFERFYRVDKARSRKLGGTGLGLAIAKEVVLAHGGTIWAESK-EHKGTTIYFTLP 597
Cdd:TIGR03785 643 EDMGEQLFDSMVSVRDQGAQDQPHLGLGLYIVRLIADFHQGRIQAENRqQNDGVVFRISLP 703
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
375-577 |
1.20e-17 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 85.86 E-value: 1.20e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 375 RERRqFVANVSHELRTPLTTMKSYLE----ALADGAWQDKDIAprfiQVVQNeTERMIRLVNDLLHLSKLDSKDYKLKKT 450
Cdd:PRK10337 236 RERR-FTSDAAHELRSPLAALKVQTEvaqlSDDDPQARKKALL----QLHAG-IDRATRLVDQLLTLSRLDSLDNLQDVA 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 451 WINFSAYFHK-VIDRFELTKSDNIRFVRKIPREAIFIEVDEDKITQVLDNIISNALKYSPQGGTITFRVrklsDEMIVSV 529
Cdd:PRK10337 310 EIPLEDLLQSaVMDIYHTAQQAGIDVRLTLNAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTL----NARNFTV 385
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 523588760 530 SDEGVGIPKADLAKIFERFYRvdkARSRKLGGTGLGLAIAKEVVLAHG 577
Cdd:PRK10337 386 RDNGPGVTPEALARIGERFYR---PPGQEATGSGLGLSIVRRIAKLHG 430
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
376-442 |
1.60e-17 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 76.84 E-value: 1.60e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 523588760 376 ERRQFVANVSHELRTPLTTMKSYLEALADGAWQDKDiaPRFIQVVQNETERMIRLVNDLLHLSKLDS 442
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQ--REYLETILREAERLLRLINDLLDLSRIEA 65
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
374-439 |
1.87e-17 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 76.87 E-value: 1.87e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 523588760 374 DRERRQFVANVSHELRTPLTTMKSYLEALADGAWQDKDIApRFIQVVQNETERMIRLVNDLLHLSK 439
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQR-EYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-597 |
1.08e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 75.95 E-value: 1.08e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 493 ITQVLDNIISNALKYSpqGGTITFRVRKLSDEMIVSVSDEGVGIPKADLAKIFERFYRVDKARSrkLGGTGLGLAIAKEV 572
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQRI 76
|
90 100
....*....|....*....|....*
gi 523588760 573 VLAHGGTIWAESKEHKGTTIYFTLP 597
Cdd:cd16950 77 SDAHGGSLTLANRAGGGLCARIELP 101
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
268-598 |
1.24e-16 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 81.67 E-value: 1.24e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 268 VLTHMTDGVIATDRRGRVILINDAALNILNVSRETVLSSSIVDVLGIAdQYTFETLLEERDS--LILD----FSTDEELY 341
Cdd:PRK11073 12 ILNSLINSILLLDDDLAIHYANPAAQQLLAQSSRKLFGTPLPELLSYF-SLNIELMRESLQAgqGFTDnevtLVIDGRSH 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 342 ILRASLSVIQkeggfvNGLIVV-LHDITEQEKIDRERRQ---------FVANVSHELRTPLTTMK---SYLE-ALADGAW 407
Cdd:PRK11073 91 ILSLTAQRLP------EGMILLeMAPMDNQRRLSQEQLQhaqqvaardLVRGLAHEIKNPLGGLRgaaQLLSkALPDPAL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 408 QDkdiaprFIQVVQNETERMIRLVNDLLHLSKLDskdyklKKTWINFSAYFHKVIDRFELTKSDNIRFVR----KIPRea 483
Cdd:PRK11073 165 TE------YTKVIIEQADRLRNLVDRLLGPQRPG------THVTESIHKVAERVVQLVSLELPDNVRLIRdydpSLPE-- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 484 ifIEVDEDKITQVLDNIISNALK-YSPQGGTITFRVR------------KLSDEmiVSVSDEGVGIPkADLAKIFerFYR 550
Cdd:PRK11073 231 --LAHDPDQIEQVLLNIVRNALQaLGPEGGTITLRTRtafqltlhgeryRLAAR--IDIEDNGPGIP-PHLQDTL--FYP 303
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 523588760 551 VDKARSrklGGTGLGLAIAKEVVLAHGGTIWAES-KEHKGTTIYftLPL 598
Cdd:PRK11073 304 MVSGRE---GGTGLGLSIARNLIDQHSGKIEFTSwPGHTEFSVY--LPI 347
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
380-598 |
1.32e-16 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 83.87 E-value: 1.32e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 380 FVANVSHELRTPLTTMKSYLEALadgawQDKDI---APRFIQVVQNETERMIRLVNDLLHLSKLDSKDYKLK------KT 450
Cdd:PRK10841 450 FLATVSHELRTPLYGIIGNLDLL-----QTKELpkgVDRLVTAMNNSSSLLLKIISDILDFSKIESEQLKIEprefspRE 524
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 451 WINF--SAYFHKVidrfeltksdnirfVRKipREAI--FIEVD------ED--KITQVLDNIISNALKYSPQGGtITFRV 518
Cdd:PRK10841 525 VINHitANYLPLV--------------VKK--RLGLycFIEPDvpvalnGDpmRLQQVISNLLSNAIKFTDTGC-IVLHV 587
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 519 RKLSDEMIVSVSDEGVGIPKADLAKIFERFYRVDKARSRKLGGTGLGLAIAKEVVLAHGGTIWAESKEHKGTTIYFTLPL 598
Cdd:PRK10841 588 RVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMDGDISVDSEPGMGSQFTIRIPL 667
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
376-600 |
5.08e-16 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 80.72 E-value: 5.08e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 376 ERRQFVANVSHELRTPLT-------TMKSYLEALADGAWQDKD----IAPRFIQVVQ--NETERMIRLVNDLLHLSKLDS 442
Cdd:PRK09467 228 DRTLLMAGVSHDLRTPLTrirlateMMSEEDGYLAESINKDIEecnaIIEQFIDYLRtgQEMPMEMADLNALLGEVIAAE 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 443 KDYklkktwinfsayfHKVIdrfELTKSDNIRfvrKIPREAIfievdedKITQVLDNIISNALKYSpqGGTItfRVRKLS 522
Cdd:PRK09467 308 SGY-------------EREI---ETALQPGPI---EVPMNPI-------AIKRALANLVVNAARYG--NGWI--KVSSGT 357
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 523 DEMIV--SVSDEGVGIPKADLAKIFERFYRVDKARSRKlgGTGLGLAIAKEVVLAHGGTIWAESKEHKGTTIYFTLPLER 600
Cdd:PRK09467 358 EGKRAwfQVEDDGPGIPPEQLKHLFQPFTRGDSARGSS--GTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLPLTT 435
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
269-604 |
1.45e-14 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 76.49 E-value: 1.45e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 269 LTHMTDGVIATDRRGRVILINDAALNILNVSR---ETVLSSSIVDVLGIADqytFETLLEERDSLIldfstDEElYILRA 345
Cdd:PRK11086 227 LQSIKEGVIAVDDRGEVTLINDEAKRLFNYKKgleDDPLGTDVESWMPVSR---LKEVLRTGTPRR-----DEE-INING 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 346 SLSVIQKEGGFVNGLIV----VLHDITEqekidrerrqfvanVSHeLRTPLTTMKSYLEALAdgawqdkdiaprfiqvvQ 421
Cdd:PRK11086 298 RLLLTNTVPVRVNGEIIgaiaTFRDKTE--------------VRQ-LAQRLDGMVNYADALR-----------------A 345
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 422 NETERMIRL--VNDLLHLSKLDSKDYKLKKTWINFSAYFHKVIDR--------FELTKSDNIR------------FVRKI 479
Cdd:PRK11086 346 QSHEFMNKLhvILGLLHLKSYDQLEDYILKTANNYQEEIGSLLGKikspviagFLLGKISRARelgitliisedsQLPDS 425
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 480 PREAIFIEVdedkITqVLDNIISNALKYSPQ--GGTITFRVRKLSDEMIVSVSDEGVGIPKADLAKIFERFYrvdkarSR 557
Cdd:PRK11086 426 GDEDQVHEL----IT-ILGNLIENALEAVGGeeGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGY------ST 494
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 523588760 558 KLGGTGLGLAIAKEVVLAHGGTIWAESKEHKGTTIYFTLPLEREQKD 604
Cdd:PRK11086 495 KGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIPWDGERSN 541
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
361-598 |
1.65e-14 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 77.03 E-value: 1.65e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 361 IVVLHDITEQEKIDR-----ERRQ----FVANVSHELRTPLTTMKSYLEaLADGAWQDKDIAPRFIQVVQNETERMIRLV 431
Cdd:PRK13837 425 IERRRLETERDALERrlehaRRLEavgtLASGIAHNFNNILGAILGYAE-MALNKLARHSRAARYIDEIISAGARARLII 503
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 432 NDLLHLSKldSKDYKLKKtwINFSAYFHKVIDRFELTKSDNIRFVRKIPREAIFIEVDEDKITQVLDNIISNALKYSPQG 511
Cdd:PRK13837 504 DQILAFGR--KGERNTKP--FDLSELVTEIAPLLRVSLPPGVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAMDGA 579
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 512 GTITFRVRKLS---------------DEMIVSVSDEGVGIPKADLAKIFERFYrvdKARSrklGGTGLGLAIAKEVVLAH 576
Cdd:PRK13837 580 GRVDISLSRAKlrapkvlshgvlppgRYVLLRVSDTGAGIDEAVLPHIFEPFF---TTRA---GGTGLGLATVHGIVSAH 653
|
250 260
....*....|....*....|..
gi 523588760 577 GGTIWAESKEHKGTTIYFTLPL 598
Cdd:PRK13837 654 AGYIDVQSTVGRGTRFDVYLPP 675
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-596 |
4.09e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 65.56 E-value: 4.09e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 493 ITQVLDNIISNALK--YSPQGGTITFRVRKLSDEMIVSVSDEGVGIPKADLAKIFERFYrvdkaRSRKLG-GTGLGLAIA 569
Cdd:cd16976 1 IQQVLMNLLQNALDamGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFF-----TTKPVGkGTGLGLSIS 75
|
90 100
....*....|....*....|....*..
gi 523588760 570 KEVVLAHGGTIWAESKEHKGTTIYFTL 596
Cdd:cd16976 76 YGIVEEHGGRLSVANEEGAGARFTFDL 102
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
472-584 |
2.53e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 64.19 E-value: 2.53e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 472 NIRFVRKIPREAIFIeVDEDKITQVLDNIISNALKYSPQGGTITfrVRKLSDEMIVSVSDEGVGIPKADLAKIFERFYRV 551
Cdd:cd16954 18 GVSISLDISPELRFP-GERNDLMELLGNLLDNACKWCLEFVEVT--ARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRL 94
|
90 100 110
....*....|....*....|....*....|...
gi 523588760 552 DKARSrklgGTGLGLAIAKEVVLAHGGTIWAES 584
Cdd:cd16954 95 DEQRP----GQGLGLAIAKEIVEQYGGELSLSD 123
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
38-589 |
6.83e-12 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 68.17 E-value: 6.83e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 38 ETELVQNFKNSLNERVTLLA--------YNVEQAMNReRDEKSPTLEEDIRSLLHdfVSQDISEVRVIDE-------KGK 102
Cdd:COG4192 190 ELQLLLRLLAIENQIVSLLRevaaardqADVDNLFDR-LQYLKDELDRNLQALKN--YPSTITLRQLIDEllaigsgEGG 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 103 VLATSNPYMQ-NIVGKRTTEIYVKRSLVTGEIVDRMLLDSKTGHRMYISSTPiktsgeikgviyviasmenvfSQMRQIN 181
Cdd:COG4192 267 LPSLRRDELAaQATLEALAEENNSILEQLRTQISGLVGNSREQLVALNQETA---------------------QLVQQSG 325
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 182 MILATGTGIALAITAVLGIFL-SRTITRPISDMRRQALAMTRGDFSRKVKVYGYDEIGQLAMTFNNLTKKLQEA--QATT 258
Cdd:COG4192 326 ILLLAIALLSLLLAVLINYFYvRRRLVKRLNALSDAMAAIAAGDLDVPIPVDGNDEIGRIARLLRVFRDQAIEKtqELET 405
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 259 EGERRKLesvlthmtdgvIATDRRgrvilindaalnilnvsretvlsssivdvlgiadqytfetlleerdslildfSTDE 338
Cdd:COG4192 406 EIEERKR-----------IEKNLR----------------------------------------------------QTQD 422
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 339 ELyilraslsvIQKEGGFVNGlivvlhditeqekidrerrQFVANVSHELRTPLTTMKSYLEALADGAWQDK-DIAPRFI 417
Cdd:COG4192 423 EL---------IQAAKMAVVG-------------------QTMTSLAHELNQPLNAMSMYLFSAKKALEQENyAQLPTSL 474
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 418 QVVQNETERMIRLVNDLLHLSKLDSKDYKlkktwinfSAYFHKVI-DRFELTKSDNIR--FVRKIPREaIFIEVDEDKIT 494
Cdd:COG4192 475 DKIEGLIERMDKIIKSLRQFSRKSDTPLQ--------PVDLRQVIeQAWELVESRAKPqqITLHIPDD-LMVQGDQVLLE 545
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 495 QVLDNIISNALKYSPQGGTITFRVRKLSDEMIVSVSDEGVGIPKADlaKIFERFYrvdkarSRKLGGTGLGLAIAKEVVL 574
Cdd:COG4192 546 QVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGWPLVD--KLFTPFT------TTKEVGLGLGLSICRSIMQ 617
|
570
....*....|....*
gi 523588760 575 AHGGTIWAESKEHKG 589
Cdd:COG4192 618 QFGGDLYLASTLERG 632
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
207-251 |
1.62e-11 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 59.00 E-value: 1.62e-11
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 523588760 207 TRPISDMRRQALAMTRGDFSRKVKVYGYDEIGQLAMTFNNLTKKL 251
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
65-389 |
2.76e-11 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 66.06 E-value: 2.76e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 65 NRERDEKSPTLEEDIRSLLHDFVSQDISEVRVIDEKGKVLATSNPYMQNIVGKRTTEIYVKRSLVTGEIVDRMLLDSKTG 144
Cdd:COG3850 1 LRELLLLALALLRLLLALLALLLLALLLLSLLALLLLLERTLLRLLSLLASAGLLAALLAALLLLLSLGLLALLLALLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 145 HRMYISSTPIKTSGEIKGVIYVIASMENVFSQMRQINMILATGTGIALAITAVLGIFLSRTITRPISDMRRQALAMTRGD 224
Cdd:COG3850 81 LLLLLLAALLSLLLLLLLLLLLLLLLLLLLLAAAINRKLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 225 FSRKVKVYGYDEIGQLAMTFNNLTKKLQEAQATTEGERRKLESVLTHMTDGVIATDRRGRVILINDAALNILNVSRETVL 304
Cdd:COG3850 161 FDARVPVSGRDELGTLARAFNRMADELQELYAELEEEEELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 305 SSSIVDVLGIADQYTFETLLEERDSLILDFSTDEELYILRASLSVIQKEGGFVNGLIVVLHDITEQEKIDRERRQFVANV 384
Cdd:COG3850 241 LLLLQDALAESELLALNILAGLLELLLALLLLLLASALLLLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLL 320
|
....*
gi 523588760 385 SHELR 389
Cdd:COG3850 321 QAIAN 325
|
|
| HAMP |
pfam00672 |
HAMP domain; |
201-253 |
4.09e-11 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 58.40 E-value: 4.09e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 523588760 201 FLSRTITRPISDMRRQALAMTRGDFSRKVKVYGYDEIGQLAMTFNNLTKKLQE 253
Cdd:pfam00672 1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-597 |
4.11e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 60.11 E-value: 4.11e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 493 ITQVLDNIISNALK-YSPQGGTITFRVR----------KLSDEMIVSVSDEGVGIPkADLA-KIFERFYrvdkarSRKLG 560
Cdd:cd16918 1 LIQVFLNLVRNAAQaLAGSGGEIILRTRtqrqvtlghpRHRLALRVSVIDNGPGIP-PDLQdTIFYPMV------SGREN 73
|
90 100 110
....*....|....*....|....*....|....*...
gi 523588760 561 GTGLGLAIAKEVVLAHGGTIWAESkeHKGTTIY-FTLP 597
Cdd:cd16918 74 GTGLGLAIAQNIVSQHGGVIECDS--QPGHTVFsVSLP 109
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
262-379 |
8.67e-11 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 64.41 E-value: 8.67e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 262 RRKLESVLTHMTDGVIATDRRGRVILINDAALNILNVSRETVLSSSIVDVLgiaDQYTFETLLEERDSLILDF-STDEEL 340
Cdd:COG3829 10 EEELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVTELI---PNSPLLEVLKTGKPVTGVIqKTGGKG 86
|
90 100 110
....*....|....*....|....*....|....*....
gi 523588760 341 YILRASLSVIqKEGGFVNGLIVVLHDITEQEKIDRERRQ 379
Cdd:COG3829 87 KTVIVTAIPI-FEDGEVIGAVETFRDITELKRLERKLRE 124
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
495-597 |
8.81e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 59.32 E-value: 8.81e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 495 QVLDNIISNALKYSPQGGTITFRVR---------KLSDEMI------VSVSDEGVGIPKADLAKIFERFYRvdkarSRKL 559
Cdd:cd16919 3 LAILNLAVNARDAMPEGGRLTIETSnqrvdadyaLNYRDLIpgnyvcLEVSDTGSGMPAEVLRRAFEPFFT-----TKEV 77
|
90 100 110
....*....|....*....|....*....|....*....
gi 523588760 560 G-GTGLGLAIAKEVVLAHGGTIWAESKEHKGTTIYFTLP 597
Cdd:cd16919 78 GkGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
489-597 |
2.12e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 57.93 E-value: 2.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 489 DEDKITQVLDNIISNA---LKYSPQG-GTITFRVRKLSDEMIV-SVSDEGVGIPKADLAKIFERfYRVDKARsrklgGTG 563
Cdd:cd16944 1 DTTQISQVLTNILKNAaeaIEGRPSDvGEVRIRVEADQDGRIVlIVCDNGKGFPREMRHRATEP-YVTTRPK-----GTG 74
|
90 100 110
....*....|....*....|....*....|....
gi 523588760 564 LGLAIAKEVVLAHGGTIWAESKEHKGTTIYFTLP 597
Cdd:cd16944 75 LGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
496-597 |
2.21e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 57.68 E-value: 2.21e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 496 VLDNIISNALKYS----PQGGTITFRVRKLSDEMIVSVSDEGVGIPKADLAKIFERFYrvdkaRSRKLGGTGLGLAIAKE 571
Cdd:cd16915 4 IVGNLIDNALDALaatgAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGV-----STKGQGERGIGLALVRQ 78
|
90 100
....*....|....*....|....*.
gi 523588760 572 VVLAHGGTIWAESKEHKGTTIYFTLP 597
Cdd:cd16915 79 SVERLGGSITVESEPGGGTTFSIRIP 104
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
204-256 |
3.63e-10 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 55.72 E-value: 3.63e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 523588760 204 RTITRPISDMRRQALAMTRGDFSRKVKVYGYDEIGQLAMTFNNLTKKLQEAQA 256
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
501-597 |
3.97e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 56.41 E-value: 3.97e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 501 ISNALKYSPqGGTITFRVRKLSDEMIVSVSDEGVGIPKADlakiferfyrvdkarsrKLGGTGLGLAIAKEVVLAHGGTI 580
Cdd:cd16917 9 LTNALKHAG-ASRVRVTLSYTADELTLTVVDDGVGFDGPA-----------------PPGGGGFGLLGMRERAELLGGTL 70
|
90
....*....|....*..
gi 523588760 581 WAESKEHKGTTIYFTLP 597
Cdd:cd16917 71 TIGSRPGGGTRVTARLP 87
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
7-384 |
4.33e-10 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 62.82 E-value: 4.33e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 7 FRSIHFKFVIIYVLLILVAMQIIGVYFVRKLETELVQNFKNSLNERVTLLAYNVEQAMNRERDEKSPTLEEDIRSLLHDF 86
Cdd:COG2770 41 LLLLLLLALLLLLLLLLLLLLAALVLLALLLAAALLLLLLLLSLVALAALLLALLLLLLLALLLLLAALLLLLLLAALAL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 87 VSQDISEVRVIDEKGKVLATSNPYMQNIVGKRTTEIYVKRSLVTGEIVDRMLLDSKTGHRMYISSTPIKTSGEIKGVIYV 166
Cdd:COG2770 121 LLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAALALALGAGELLLLADLAAAIAALLAALLLLLLGGLLL 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 167 IASMENVFSQMRQINMIlatgTGIALAITAVLGIFLSRTITRPISDMRRQALAMTRGDFSRKVKVYGYDEIGQLAMTFNN 246
Cdd:COG2770 201 VVLLEAALAALLLLLLL----ALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNR 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 247 LTKKLQEAQATTEGERRKLESVLTHMTDGVIATDRRGRVILINDAALNILNVSRETVLSSSIVDVLGIADQYTFETLLEE 326
Cdd:COG2770 277 MADSLRESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALAL 356
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 523588760 327 RDSLILDFSTDEELYILRASLSVIQKEGGFVNGLIVVLHDITEQEKIDRERRQFVANV 384
Cdd:COG2770 357 AALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVL 414
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
369-601 |
4.64e-10 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 60.40 E-value: 4.64e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 369 EQEKIDRERRQFVA----NVSHELrtplTTMKSYLEALADGAWQDKDIAPRFIQVVQNETERMIRLVNDLLH-LSKLDSK 443
Cdd:COG4585 46 AEEAREEERRRIARelhdGVGQSL----SAIKLQLEAARRLLDADPEAAREELEEIRELAREALAELRRLVRgLRPPALD 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 444 DYKLkktwinfSAYFHKVIDRFELTKSDNIRFVRKIPREAIFIEVDEDkITQVLDNIISNALKYSpQGGTITFRVRKLSD 523
Cdd:COG4585 122 DLGL-------AAALEELAERLLRAAGIRVELDVDGDPDRLPPEVELA-LYRIVQEALTNALKHA-GATRVTVTLEVDDG 192
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 523588760 524 EMIVSVSDEGVGIPKAdlakiferfyrvdkarsrKLGGTGLGLAIAKEVVLAHGGTIWAESKEHKGTTIYFTLPLERE 601
Cdd:COG4585 193 ELTLTVRDDGVGFDPE------------------AAPGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPLAAA 252
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
263-367 |
6.01e-10 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 57.04 E-value: 6.01e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 263 RKLESVLTHMTDGVIATDRRGRVILINDAALNILNVSRETVLSSSIVDVLGIADQYTFETLL--------EERDSLILDF 334
Cdd:pfam00989 1 EDLRAILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIPEEDDAEVAELLrqallqgeESRGFEVSFR 80
|
90 100 110
....*....|....*....|....*....|...
gi 523588760 335 STDEELYILRASLSVIQKEGGFVNGLIVVLHDI 367
Cdd:pfam00989 81 VPDGRPRHVEVRASPVRDAGGEILGFLGVLRDI 113
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
374-580 |
9.05e-10 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 61.19 E-value: 9.05e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 374 DRER----RQFVANVSHELRTPLTTMKSYLEALADGAWQDKDIA-PrfiqVVQNETERMIRLVNDLLHLSKLDSKDYKLK 448
Cdd:PRK10815 259 ERERytkyRTTLTDLTHSLKTPLAVLQSTLRSLRSGKQMSVEQAeP----IMLEQISRISQQIGYYLHRASMRSEHNLLS 334
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 449 KTwinfsayFHKV---IDRfeLTKSDNIRFVRK-------IPREAIFIEVDEDkITQVLDNIISNALKYSPQGGTITfrV 518
Cdd:PRK10815 335 RE-------LHSVaplLDN--LTSALNKVYQRKgvnitldISPEITFVGEKND-FMEVMGNVLDNACKYCLEFVEIS--A 402
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 523588760 519 RKLSDEMIVSVSDEGVGIPKADLAKIFERFYRVDKARSrklgGTGLGLAIAKEVVLAHGGTI 580
Cdd:PRK10815 403 RQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRP----GQGLGLSVAREITEQYEGKI 460
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
14-253 |
9.12e-10 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 61.57 E-value: 9.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 14 FVIIYVLLILVAMQIIGVYFVRKLETELVQNFKNSLNERVTLLAYNVEQAMNRERDEKSPTLEEDIRSLLHDFVSQDISE 93
Cdd:COG0840 12 LALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLALLLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 94 VR--VIDEKGKVLATSNPYMQNIVGKRTTEIYVKRSLVTGEIVDRMLLDSKTGHRMYISSTPIKTSGEIKGVIYVIASME 171
Cdd:COG0840 92 LLalLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALLEAAA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 172 NVFSQMRQINMILATGTGIALAITAVLGIFLSRTITRPISDMRRQALAMTRGDFSRKVKVYGYDEIGQLAMTFNNLTKKL 251
Cdd:COG0840 172 LALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENL 251
|
..
gi 523588760 252 QE 253
Cdd:COG0840 252 RE 253
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
253-379 |
1.06e-09 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 59.65 E-value: 1.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 253 EAQATTEGERRKLESVLTHMTDGVIATDRRGRVILINDAALNILNVSRETVLSSSIVDVLGIADQYTFETLLEERDSLIL 332
Cdd:COG2202 1 TAEEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLPPEDDDEFLELLRAALAGGG 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 523588760 333 DFST-------DEELYILRASLSVIQKEGGFVNGLIVVLHDITEQEKIDRERRQ 379
Cdd:COG2202 81 VWRGelrnrrkDGSLFWVELSISPVRDEDGEITGFVGIARDITERKRAEEALRE 134
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
379-594 |
3.24e-09 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 59.68 E-value: 3.24e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 379 QFVANVSHELRTPLTTMKSYLEALADGAWQDKDIAPRFIQVVQN---ETERMIRLVNDLLHLSKldskDYKLKKTWINFS 455
Cdd:PRK13557 165 QLTGGIAHDFNNLLQVMSGYLDVIQAALSHPDADRGRMARSVENiraAAERAATLTQQLLAFAR----KQRLEGRVLNLN 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 456 AYFHKVIDRFELTKSDNIRFVRKIPREAIFIEVDEDKITQVLDNIISNALKYSPQGGTITFRVRKLS----DEMI----- 526
Cdd:PRK13557 241 GLVSGMGELAERTLGDAVTIETDLAPDLWNCRIDPTQAEVALLNVLINARDAMPEGGRVTIRTRNVEiedeDLAMyhglp 320
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 523588760 527 ------VSVSDEGVGIPKADLAKIFERFYrVDKARSRklgGTGLGLAIAKEVVLAHGGTIWAESKEHKGTT--IYF 594
Cdd:PRK13557 321 pgryvsIAVTDTGSGMPPEILARVMDPFF-TTKEEGK---GTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTvrLYF 392
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
132-601 |
5.04e-09 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 58.88 E-value: 5.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 132 EIVDRMLLDSKTGHRMYISSTPIKTSGEIKGVIYVIASMENVFSQMRQINMILATGTGIALAITAVLGIFLSRTITRPIS 211
Cdd:COG2972 107 LLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLRRLILLIILLLLLLALLLSYLLSRSITRPIK 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 212 DMRRQALAMTRGDFSRkVKVYGYDEIGQLAMTFNNLTKKLQEAQATT-EGERRKLESVLthmtdgviatdrrgrvilind 290
Cdd:COG2972 187 RLKKAMKKVEKGDLVR-LEVSGNDEIGILARSFNEMVERIKELIEEVyELELEKKEAEL--------------------- 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 291 AAL----------NILNVSRETVLSSSIVDVlgiadqytfetlleerDSLILDFSTdeelyILRASLSVIQKEggfvngl 360
Cdd:COG2972 245 KALqaqinphflfNTLNSIRWLAELEDPEEA----------------EEMLEALSK-----LLRYSLSKGDEL------- 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 361 ivvlhdITEQEKIDrerrqfvanvshelrtpltTMKSYLEaladgawqdkdiaprfIQVVqnetermirlvndllhlskl 440
Cdd:COG2972 297 ------VTLEEELE-------------------LIKSYLE----------------IQKL-------------------- 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 441 dskdyklkktwinfsayfhkvidRFEltksDNIRFVrkipreaifIEVDEDKITQV---------LDNIISNALKYSPQG 511
Cdd:COG2972 316 -----------------------RFG----DRLEVE---------IEIDEELLDLLipklilqplVENAIEHGIEPKEGG 359
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 512 GTITFRVRKLSDEMIVSVSDEGVGIPKADLAKIFERFyrvdkarSRKLGGTGLGLAIAKE-VVLAHGG--TIWAESKEHK 588
Cdd:COG2972 360 GTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-------SSKGEGRGIGLRNVRErLKLYYGEeyGLEIESEPGE 432
|
490
....*....|...
gi 523588760 589 GTTIYFTLPLERE 601
Cdd:COG2972 433 GTTVTIRIPLEEE 445
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
272-367 |
9.07e-09 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 53.41 E-value: 9.07e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 272 MTDGVIATDRRGRVILINDAALNILNVSRETVLSSSIVDVLGIADQYTFETLLEERDSLILDFSTDEELYI-------LR 344
Cdd:cd00130 1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLLSGGEPVTLEVRLRRkdgsviwVL 80
|
90 100
....*....|....*....|...
gi 523588760 345 ASLSVIQKEGGFVNGLIVVLHDI 367
Cdd:cd00130 81 VSLTPIRDEGGEVIGLLGVVRDI 103
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
163-602 |
1.92e-08 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 57.22 E-value: 1.92e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 163 VIYVIASMENVFSQMRQINMILATGTGIALAITAVLGIFLSRTITRPISDMRRQALAMTRGDFSRKVKVYGYDEIGQLAM 242
Cdd:COG3920 69 VALAAAVGAAAALLALLVLLLLLLLAAAALALALLLAALAGLLLLAALLLLRLVALLAALALLALLLLLLLLLAILALAE 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 243 TFNNLTKKLQEAQATTEGERRKLESVLTHMTDGVIATDRRGRVILINDAA-----LNILNVSRETVLSSSIVDVLGIADQ 317
Cdd:COG3920 149 LAVALAELAAALLLLAEELAALRLAAAALLLLLAALLDLGLALAALAAAAllallLALELLLALLLLLLLLLALLLVLLA 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 318 YTFETLLEERDSLILDFSTDEELYILRASLSVIQKEGGFVNGLIVVLHDITEQEKIDRERRQFVAN-------VSHELRT 390
Cdd:COG3920 229 ALLRLRAAVLEELERRRRARGLGRLLLLLLLLLLLLRALLLLAAGIRLVITERKRAEEELEASLEEkelllreLHHRVKN 308
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 391 PLTTMKSYLEALADGAwQDKDIApRFIQVVQNeteRM--IRLVNDLLHLSKLDSKdyklkktwINFSAYFHKVIDRF-EL 467
Cdd:COG3920 309 NLQVVSSLLRLQARRA-DDPEAR-EALEESQN---RIqaLALVHELLYQSEDWEG--------VDLRDYLRELLEPLrDS 375
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 468 TKSDNIRFVRKIPreaiFIEVDEDKITQ---VLDNIISNALKY---SPQGGTITFRVRKLSDEMIVSVSDEGVGIPKadl 541
Cdd:COG3920 376 YGGRGIRIELDGP----DVELPADAAVPlglILNELVTNALKHaflSGEGGRIRVSWRREDGRLRLTVSDNGVGLPE--- 448
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 523588760 542 akiferfyRVDKARSRklggtGLGLAIAKEVVLAHGGTIwaESKEHKGTTIYFTLPLEREQ 602
Cdd:COG3920 449 --------DVDPPARK-----GLGLRLIRALVRQLGGTL--ELDRPEGTRVRITFPLAELA 494
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
263-605 |
5.02e-08 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 55.99 E-value: 5.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 263 RKLESVLTHMTDGVIATDRRGRVILINDAALNILNVSR--ETVLSSSIVDVLGIADQYTfETLLEERDSLILDFStdeel 340
Cdd:PRK15053 222 RQQEALFSSVYEGLIAVDPHGYITAINRNARKMLGLSSpgRQWLGKPIAEVVRPADFFT-EQIDEKRQDVVANFN----- 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 341 yilraSLSVIQKEGGFVNGLIVVLHDITEQEKIDrerrqfvanvSHELRTPLTTMKSYLEALA-------------DGAW 407
Cdd:PRK15053 296 -----GLSVIANREAIRSGDDLLGAIISFRSKDE----------ISTLNAQLTQIKQYVESLRtlrhehlnwmstlNGLL 360
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 408 QDKDIaPRFIQVVQNETERMIRLVnDLLHLSKLDSKDYKLkktwinfsaYFHKVIDRFELtkSDNIRFVRKIPREAIFIE 487
Cdd:PRK15053 361 QMKEY-DRVLEMVQGESQAQQQLI-DSLREAFADRQVAGL---------LFGKVQRAREL--GLKMVIVPGSQLSQLPPG 427
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 488 VDEDKITQVLDNIISNALKYS---PQGG-TITFRVRKLSDEMIVSVSDEGVGIPKADLAKIFERFYrvdKARSRKLGGTG 563
Cdd:PRK15053 428 LDSTEFAAIVGNLLDNAFEASlrsDEGNkIVELFLSDEGDDVVIEVADQGCGVPESLRDKIFEQGV---STRADEPGEHG 504
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 523588760 564 LGLAIAKEVVLAHGGTIWAESKEHKGTtiYFTLPLEREQKDD 605
Cdd:PRK15053 505 IGLYLIASYVTRCGGVITLEDNDPCGT--LFSIFIPKVKPND 544
|
|
| PAS_9 |
pfam13426 |
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ... |
283-369 |
6.41e-08 |
|
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463873 [Multi-domain] Cd Length: 93 Bit Score: 50.54 E-value: 6.41e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 283 GRVILINDAALNILNVSRETVLSSSIVDVLGIADQYTFETLLEERDSLILDFST-----DEELYILRASLSVIQKEGGFV 357
Cdd:pfam13426 2 GRIIYVNDAALRLLGYTREELLGKSITDLFAEPEDSERLREALREGKAVREFEVvlyrkDGEPFPVLVSLAPIRDDGGEL 81
|
90
....*....|..
gi 523588760 358 NGLIVVLHDITE 369
Cdd:pfam13426 82 VGIIAILRDITE 93
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
474-598 |
9.73e-08 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 51.07 E-value: 9.73e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 474 RFVRKIPREAIFIEVDEDKITQVLDNIISNALKYSPQG---GTITFRVRKLSDEMIVSVSDEGVGIPKADLAkiferfyr 550
Cdd:COG2172 16 RAVRALLRELGLDEDDADDLVLAVSEAVTNAVRHAYGGdpdGPVEVELELDPDGLEIEVRDEGPGFDPEDLP-------- 87
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 523588760 551 vDKARSRKLGGTGLGL--AIAKEVVLAHGGTiwaeskehkGTTIYFTLPL 598
Cdd:COG2172 88 -DPYSTLAEGGRGLFLirRLMDEVEYESDPG---------GTTVRLVKRL 127
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
249-377 |
8.55e-07 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 50.79 E-value: 8.55e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 249 KKLQEAQATTEgerRKLESVLTHMTDGVIATDRRGRVILINDAALNILNVSRETVLSSSIVDVLGIADQYTFETLLEERD 328
Cdd:COG2202 126 KRAEEALRESE---ERLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKSLLDLLHPEDRERLLELLRRLL 202
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 523588760 329 SLILDFST--------DEELYILRASLSVIQKEGGFVnGLIVVLHDITEQEKIDRER 377
Cdd:COG2202 203 EGGRESYElelrlkdgDGRWVWVEASAVPLRDGGEVI-GVLGIVRDITERKRAEEAL 258
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
263-326 |
1.30e-06 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 45.85 E-value: 1.30e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 523588760 263 RKLESVLTHMTDGVIATDRRGRVILINDAALNILNVSRETVLSSSIVDVLGIADQYTFETLLEE 326
Cdd:smart00091 1 ERLRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHPEDRERVQEALQR 64
|
|
| TyrR |
COG3283 |
Transcriptional regulator TyrR of aromatic amino acids metabolism [Transcription, Amino acid ... |
258-313 |
9.45e-06 |
|
Transcriptional regulator TyrR of aromatic amino acids metabolism [Transcription, Amino acid transport and metabolism];
Pssm-ID: 442513 [Multi-domain] Cd Length: 514 Bit Score: 48.65 E-value: 9.45e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 523588760 258 TEGERRKLESVLTHMTDGVIATDRRGRVILINDAALNILNVSRETVLSSSIVDVLG 313
Cdd:COG3283 75 SEREHLELDALLEALPDPVFSIDLKGKIELANPAALSLLGLSEEELIGQPLSELLK 130
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
369-605 |
1.28e-05 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 48.39 E-value: 1.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 369 EQEKIDRERRQFVANVSHELRTPLTTMKSYLEALADGawQDKDIAPRFIQVVQNETERMIRLVNDLLHLSKLDSKDYKLK 448
Cdd:PRK10618 442 EYEKNQQARKAFLQNIGDELKQPLQSLAQLAAQLRQT--SDEEQQQPELDQLAEQSDVLVRLVDNIQLLNMLETQDWKPE 519
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 449 KTwiNFSayFHKVIDRFELTKSDNIRfvRK---------IPREAIFIEvDEDkitqVLDNIISNALKYS---PQGGTITF 516
Cdd:PRK10618 520 QE--LFS--LQDLIDEVLPEVLPAIK--RKglqllihnhLKAEQLRIG-DRD----ALRKILLLLLNYAittTAYGKITL 588
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 517 RV---RKLSDEMIVSVSDEGVGIPKADLAKIfeRFYRVDKARSRKLG-GTGLGLAIAKEVVLAHGGTIWAESKEHKGTTI 592
Cdd:PRK10618 589 EVdqdESSPDRLTIRILDTGAGVSIKELDNL--HFPFLNQTQGDRYGkASGLTFFLCNQLCRKLGGHLTIKSREGLGTRY 666
|
250
....*....|...
gi 523588760 593 YFTLPLEREQKDD 605
Cdd:PRK10618 667 SIHLKMLAADPEV 679
|
|
| PRK10600 |
PRK10600 |
nitrate/nitrite two-component system sensor histidine kinase NarX; |
177-259 |
1.49e-05 |
|
nitrate/nitrite two-component system sensor histidine kinase NarX;
Pssm-ID: 182581 [Multi-domain] Cd Length: 569 Bit Score: 48.13 E-value: 1.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 177 MRQINMILATGTGIALAITAVLGIFLSRTITRPISDMRRQALAMTRGDFSRKVKVYGYDEIGQLAMTFNNLTKKLQEAQA 256
Cdd:PRK10600 120 IETVVLVHRVFAVFMALLLVFTIIWLRRRLLQPWRQLLSMANAVSHRDFTQRANISGRDEMAMLGTALNNMSAELAESYA 199
|
...
gi 523588760 257 TTE 259
Cdd:PRK10600 200 VLE 202
|
|
| PAS_4 |
pfam08448 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
269-371 |
1.85e-05 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain is associated to signalling systems and works as a signal sensor domain. It recognizes differently substituted aromatic hydrocarbons, oxygen, different dodecanoic acids, autoinducers, 3,5-dimethyl-pyrazin-2-ol and N-alanyl-aminoacetone (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 312075 [Multi-domain] Cd Length: 110 Bit Score: 43.94 E-value: 1.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 269 LTHMTDGVIATDRRGRVILINDAALNILNVSRETVLSSSIVDVLGIADQYTFETLL------EERDSLILDFSTDEELYI 342
Cdd:pfam08448 1 LDSLPDALAVLDPDGRVRYANAAAAELFGLPPEELLGKTLAELLPPEDAARLERALrralegEEPIDFLEELLLNGEERH 80
|
90 100
....*....|....*....|....*....
gi 523588760 343 LRASLSVIQKEGGFVNGLIVVLHDITEQE 371
Cdd:pfam08448 81 YELRLTPLRDPDGEVIGVLVISRDITERR 109
|
|
| HATPase_ETR2_ERS2-EIN4-like |
cd16938 |
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related ... |
489-596 |
3.73e-05 |
|
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related domains; This family includes the histidine kinase-like ATPase domains (HATPase) of three out of the five receptors that recognize the plant hormone ethylene in Arabidopsis thaliana. These three proteins have been classified as belonging to subfamily 2: ETR2, ERS2, and EIN4. They lack most of the motifs characteristic of histidine kinases, and EIN4 is the only one in this group containing the conserved histidine that is phosphorylated in two-component and phosphorelay systems. This family also includes the HATPase domains of Escherichia coli RcsD phosphotransferase which is a component of the Rcs-signaling system, a complex multistep phosphorelay involving five proteins, and is involved in many transcriptional networks such as cell division, biofilm formation, and virulence, among others. Also included is Schizosaccharomyces pombe Mak3 (Phk1) which participates in a multi-step two-component related system which regulates H2O2-induced activation of the Sty1 stress-activated protein kinase pathway. Most proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a GAF sensor domain; most are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340415 [Multi-domain] Cd Length: 133 Bit Score: 43.60 E-value: 3.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 489 DEDKITQVLDNIISNALKYSPQGGTITFRVRKLSDEMIVSVSDEGVGIPKADLAKIFERF-YRVDKARS----------- 556
Cdd:cd16938 8 DERRVFQVLLHMLGNLLKMRNGGGNITFRVFLEGGSEDRSDRDWGPWRPSMSDESVEIRFeVEINDSGSpsiesasmrns 87
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 523588760 557 ------RKLGGTGLGLAIAKEVVLAHGGTIWAESKEHKGTTIYFTL 596
Cdd:cd16938 88 lnrrynLSELGEHLSFSICKQLVQLMGGNIWIVPGSGLGTTMSLLL 133
|
|
| dCache_1 |
pfam02743 |
Cache domain; Double cache domain 1 covers the last three strands from the membrane distal ... |
40-241 |
4.31e-05 |
|
Cache domain; Double cache domain 1 covers the last three strands from the membrane distal PAS-like domain, the first two strands of the membrane proximal domain, and the connecting elements between the two domains. This domain when present in chemoreceptors recognize several signals such as proteinogenic amino acids, GABA, Histamine and polyamines, decanoic acid, Autoinducer-2, purine derivatives, quaternary amines, citrate and taurine, among others. When associated with histidine kinases, it recognizes C3/C4-dicarboxylic acids, Spermine, guanosine and Autoinducer-2 (Mantilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1 https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 460673 [Multi-domain] Cd Length: 237 Bit Score: 45.41 E-value: 4.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 40 ELVQNFKNSLNERVTLLAYNVEQAM-NRERDEKSPTLEEDIRSLLHDFV-------------SQDISEVRVIDEKGKVLA 105
Cdd:pfam02743 2 AIKEQAEEQLLSLAKQLAENIESYLdSLEEILELLASNPDLQDLLSAPAeeelaklesllrsNPGISSIYLVDADGRVLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 106 TSNPYMQNIVGKRTTEIYVKRSLVTGE----IVDRMLLDSKTGHRMYISSTPI-KTSGEIKGVIYVIASMENVFSQMRQI 180
Cdd:pfam02743 82 SSDESPSYPGLDVSERPWYKEALKGGGgiiwVFSSPYPSSESGEPVLTIARPIyDDDGEVIGVLVADLDLDTLQELLSQI 161
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 523588760 181 NMilaTGTGIALAITAvLGIFLSRTITRPI----SDMRRQALAMTRGDFSRKVKVYGYDEIGQLA 241
Cdd:pfam02743 162 KL---GEGGYVFIVDS-DGRILAHPLGKNLrsllAPFLGKSLADALPGSGITEIAVDLDGEDYLV 222
|
|
| ArlS_N |
pfam18719 |
ArlS sensor domain; This entry represents the N-terminal extracellular sensor domain of the ... |
41-180 |
4.62e-05 |
|
ArlS sensor domain; This entry represents the N-terminal extracellular sensor domain of the ArlS protein from S. aureus. It recognizes LL-37 antimicrobial peptide (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 465847 Cd Length: 127 Bit Score: 43.16 E-value: 4.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 41 LVQNFKNSLNERVTllayNVEQAMNRERDEKSPTLEEDiRSLLHDFVSQDISeVRVIDEKGKVLATSNPYMQNIVGKRTT 120
Cdd:pfam18719 5 LLDQEKQNVNETMT----EVSERLSEIDTELDQESIYS-DSLLQSLSRKNQT-IRIYDPDGKLLFSSRNDPVPFKPPKKV 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 523588760 121 EIYVKRSLVTGEivdrmlldsktGHRMYISSTPIKTS-GEIKGVIYVIASMENvFSQMRQI 180
Cdd:pfam18719 79 KSEETRKISLVK-----------GKRVLVGRSPIYSKnGLIIGYVQVVNSLES-YDSLMNK 127
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
495-597 |
3.99e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 40.10 E-value: 3.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 495 QVL-DNIISNALKYSPQGGTITFRVRKLSDEMIVSVSDEGVGIPKADLAKIFERFYRVDKarsrklgGTGLGLA-IAKEV 572
Cdd:cd16957 7 QVLvENAIRHAFPKRKENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGKTTVTSEK-------GTGTALEnLNRRL 79
|
90 100
....*....|....*....|....*..
gi 523588760 573 VLAHG--GTIWAESKEHKGTTIYFTLP 597
Cdd:cd16957 80 IGLFGseACLHIESEVHGGTEVWFVIP 106
|
|
| sensory_box |
TIGR00229 |
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ... |
261-377 |
5.33e-04 |
|
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]
Pssm-ID: 272971 [Multi-domain] Cd Length: 124 Bit Score: 40.35 E-value: 5.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 261 ERRKLESVLTHMTDGVIATDRRGRVILINDAALNILNVSRETVLSSSIVDV-----LGIADQYtFETLLEERDSLI---- 331
Cdd:TIGR00229 1 SEERYRAIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRNVLELipeedREEVRER-IERRLEGEPEPVseer 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 523588760 332 LDFSTDEELYILRASLSVIQKEGGFVNGLIVVlHDITEQEKIDRER 377
Cdd:TIGR00229 80 RVRRKDGSEIWVEVSVSPIRTNGGELGVVGIV-RDITERKEAEEAL 124
|
|
| PDC1_HK_sensor |
cd18773 |
first PDC (PhoQ/DcuS/CitA) domain of methyl-accepting chemotaxis proteins, diguanylate-cyclase ... |
66-166 |
5.78e-04 |
|
first PDC (PhoQ/DcuS/CitA) domain of methyl-accepting chemotaxis proteins, diguanylate-cyclase and similar domains; Histidine kinase (HK) receptors are part of two-component systems (TCS) in bacteria that play a critical role for sensing and adapting to environmental changes. Typically, HK receptors contain an extracellular sensing domain flanked by two transmembrane helices, an intracellular dimerization histidine phosphorylation domain (DHp), and a C-terminal kinase domain, with many variations on this theme. HK receptors in this family contain double PDC (PhoQ/DcuS/CitA) sensor domains. Signals detected by the sensor domain are transmitted through DHp to the kinase domain, resulting in the phosphorylation of a conserved histidine residue in DHp; phosphotransfer to a conserved aspartate in its cognate response regulator (RR) follows, which leads to the activation of genes for downstream cellular responses. The HK family includes not just histidine kinase receptors but also sensors for chemotaxis proteins and diguanylate cyclase receptors, implying a combinatorial molecular evolution.
Pssm-ID: 350341 [Multi-domain] Cd Length: 125 Bit Score: 40.24 E-value: 5.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 66 RERDEKSPTLEEDIRSLLHDFVSQ--DISEVRVIDEKGKVLATSNPYMQN-IVGKRTTEIYVKRSLVTGE-IVDRMLLDS 141
Cdd:cd18773 16 EALAALGSADREELQALLRRLLERnpEISGIYVVDADGRVVASSDRDPGGgDDDDDRDRFWYQAAKATGKlVISEPYISR 95
|
90 100
....*....|....*....|....*.
gi 523588760 142 KTGHRMYISSTPIKTS-GEIKGVIYV 166
Cdd:cd18773 96 VTGKPVITLSRPIRDAdGRFIGVVGA 121
|
|
| PAS_8 |
pfam13188 |
PAS domain; PAS domains are involved in many signalling proteins where they are used as a ... |
263-312 |
8.51e-04 |
|
PAS domain; PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. This domain recognizes oxygen and CO (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463802 [Multi-domain] Cd Length: 65 Bit Score: 37.91 E-value: 8.51e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 523588760 263 RKLESVLTHMTDGVIATDRRGRVILINDAALNILNVSRETVLSSSIVDVL 312
Cdd:pfam13188 1 ERLRALFESSPDGILVLDEGGRIIYVNPAALELLGYELLGELLGELLDLL 50
|
|
| HATPase_EL346-LOV-HK-like |
cd16951 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
478-597 |
8.71e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.
Pssm-ID: 340427 [Multi-domain] Cd Length: 131 Bit Score: 39.71 E-value: 8.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 478 KIPREAIFIEVDEDKITQ---VLDNIISNALKYS---PQGGTITFRVRKLSDEMIVSVSDEGVGIPKADlakiferfyrv 551
Cdd:cd16951 22 RINITGDTGPVSSEVATAiglVVNELLQNALKHAfsdREGGTITIRSVVDGDYLRITVIDDGVGLPQDE----------- 90
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 523588760 552 DKARSRKlggtgLGLAIAKEVVLAHGGTIWAESKEHKGTTIYFTLP 597
Cdd:cd16951 91 DWPNKGS-----LGLQIVRSLVEGELKAFLEVQSAENGTRVNIDIP 131
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
96-181 |
9.38e-04 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 42.07 E-value: 9.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 96 VIDEKGKVLATSNPY-------MQNIVGKRTTEIY----VKRSLVTGE-IVDRMLLDSKTGHRMYISSTPIKTSGEIKGV 163
Cdd:COG3829 26 VVDADGRITYVNRAAerilglpREEVIGKNVTELIpnspLLEVLKTGKpVTGVIQKTGGKGKTVIVTAIPIFEDGEVIGA 105
|
90
....*....|....*...
gi 523588760 164 IYVIASMENVFSQMRQIN 181
Cdd:COG3829 106 VETFRDITELKRLERKLR 123
|
|
| UhpB |
COG3851 |
Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction ... |
501-604 |
1.96e-03 |
|
Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction mechanisms];
Pssm-ID: 443060 [Multi-domain] Cd Length: 493 Bit Score: 41.15 E-value: 1.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 501 ISNALKYSpQGGTITFRVRKLSDEMIVSVSDEGVGIPKADLAKiferfyrvdkarsrklggtGLGLAIAKEVVLAHGGTi 580
Cdd:COG3851 409 LTNILKHA-EASQIRISLSQDKRLLSLEIRDDGIGLPPELRAK-------------------GFGLRGMRERVRALGGD- 467
|
90 100
....*....|....*....|....
gi 523588760 581 WAESKEHKGTTIYFTLPLEREQKD 604
Cdd:COG3851 468 FRLSSAPKGTRLSVLLPTPAASNE 491
|
|
| HATPase_RsbT-like |
cd16934 |
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine ... |
474-592 |
3.87e-03 |
|
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.
Pssm-ID: 340411 [Multi-domain] Cd Length: 117 Bit Score: 37.73 E-value: 3.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 523588760 474 RFVRKIPREAIFIEVDEDKITQVLDNIISNALKYSpQGGTITFRVRKLSDE--MIVSVSDEGVGIPkaDLAKIFERFYRV 551
Cdd:cd16934 7 RAARELARRLGLSEVRQAEIATAVTELARNLLKHA-GGGQVLLEVVAEGGRvaLEILAVDQGPGIA--DVDEALRDGFST 83
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 523588760 552 DkarsrklGGTGLGLAIAKEVVlahgGTIWAESKEHKGTTI 592
Cdd:cd16934 84 G-------GGLGLGLGGVRRLA----DEFDLHSAPGRGTVV 113
|
|
| |
