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Conserved domains on  [gi|521291339|ref|WP_020455607|]
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MULTISPECIES: 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE [Enterobacteriaceae]

Protein Classification

DMT family transporter( domain architecture ID 581036)

DMT (drug/metabolite transporter) family transporter is an inner membrane protein involved in the transport of one or more of a variety of substrates such as amino acids, drugs, metabolites, and sugar phosphates, among others

Gene Ontology:  GO:0055085|GO:0005215|GO:0005886
PubMed:  11432728
TCDB:  2.A.7

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EamA super family cl23754
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
 15-112 1.49e-40

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


The actual alignment was detected with superfamily member PRK15051:

Pssm-ID: 474045  Cd Length: 111  Bit Score: 130.32  E-value: 1.49e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521291339  15 CAGQLCQKQATRPVPMDKRNKHLGLWLGLALMALGAGMALWLLVLQRIPVGVAYPMLSLNFVWVTLAARFLWREPVSVRH 94
Cdd:PRK15051  14 VAGQLCQKQATRPVAIGKRRKHIVLWLGLALACLGLAMVLWLLVLQNVPVGIAYPMLSLNFVWVTLAAVKLWHEPVSPRH 93

                         90
                 ....*....|....*...
gi 521291339  95 AFGVALIITGIVLLGSSL 112
Cdd:PRK15051  94 WCGVAFIIGGIVILGSTV 111
 
Name Accession Description Interval E-value
PRK15051 PRK15051
4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional
 15-112 1.49e-40

4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional


Pssm-ID: 185011  Cd Length: 111  Bit Score: 130.32  E-value: 1.49e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521291339  15 CAGQLCQKQATRPVPMDKRNKHLGLWLGLALMALGAGMALWLLVLQRIPVGVAYPMLSLNFVWVTLAARFLWREPVSVRH 94
Cdd:PRK15051  14 VAGQLCQKQATRPVAIGKRRKHIVLWLGLALACLGLAMVLWLLVLQNVPVGIAYPMLSLNFVWVTLAAVKLWHEPVSPRH 93

                         90
                 ....*....|....*...
gi 521291339  95 AFGVALIITGIVLLGSSL 112
Cdd:PRK15051  94 WCGVAFIIGGIVILGSTV 111
EmrE COG2076
Multidrug transporter EmrE and related cation transporters [Defense mechanisms];
39-108 5.28e-12

Multidrug transporter EmrE and related cation transporters [Defense mechanisms];


Pssm-ID: 441679  Cd Length: 105  Bit Score: 57.42  E-value: 5.28e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 521291339  39 LWLGLALMALGAGMALWLLVLQRIPVGVAYPMLS-LNFVWVTLAARFLWREPVSVRHAFGVALIITGIVLL 108
Cdd:COG2076   29 LPSVLTVVGYALSFYLLSLALKTLPVGTAYAVWTgIGAVGTALVGILLFGEPLSLARLLGIALIIAGVVGL 99
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
 41-108 1.34e-04

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 38.33  E-value: 1.34e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 521291339   41 LGLALMALGAGMALWLLVLQRIPVGVAYPMLSLNFVWVTLAARFLWREPVSVRHAFGVALIITGIVLL 108
Cdd:pfam00892  67 LYLGVLGTFLGFLLYFYGLKYVSASNASVITSLSPVFTLILSVLLLGEKLTLKQLLGIVLILLGVLLI 134
 
Name Accession Description Interval E-value
PRK15051 PRK15051
4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional
 15-112 1.49e-40

4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional


Pssm-ID: 185011  Cd Length: 111  Bit Score: 130.32  E-value: 1.49e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521291339  15 CAGQLCQKQATRPVPMDKRNKHLGLWLGLALMALGAGMALWLLVLQRIPVGVAYPMLSLNFVWVTLAARFLWREPVSVRH 94
Cdd:PRK15051  14 VAGQLCQKQATRPVAIGKRRKHIVLWLGLALACLGLAMVLWLLVLQNVPVGIAYPMLSLNFVWVTLAAVKLWHEPVSPRH 93

                         90
                 ....*....|....*...
gi 521291339  95 AFGVALIITGIVLLGSSL 112
Cdd:PRK15051  94 WCGVAFIIGGIVILGSTV 111
EmrE COG2076
Multidrug transporter EmrE and related cation transporters [Defense mechanisms];
39-108 5.28e-12

Multidrug transporter EmrE and related cation transporters [Defense mechanisms];


Pssm-ID: 441679  Cd Length: 105  Bit Score: 57.42  E-value: 5.28e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 521291339  39 LWLGLALMALGAGMALWLLVLQRIPVGVAYPMLS-LNFVWVTLAARFLWREPVSVRHAFGVALIITGIVLL 108
Cdd:COG2076   29 LPSVLTVVGYALSFYLLSLALKTLPVGTAYAVWTgIGAVGTALVGILLFGEPLSLARLLGIALIIAGVVGL 99
PRK02971 PRK02971
4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional
 43-107 2.41e-08

4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional


Pssm-ID: 235094  Cd Length: 129  Bit Score: 48.45  E-value: 2.41e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 521291339  43 LALMALGAGMALWLLVLQRIPVGVAYPMLSLNFVWVTLAARFL--WREPVSVRHAFGVALIITGIVL 107
Cdd:PRK02971  53 LGLAGYALSMLCWLKALRYLPLSRAYPLLSLSYALVYLAAMLLpwFNETFSLKKTLGVACIMLGVWL 119
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
 35-108 9.95e-06

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 42.52  E-value: 9.95e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 521291339  35 KHLGLWLGLALMALGAGMALWLLVLQRIPVGVAYPMLSLNFVWVTLAARFLWREPVSVRHAFGVALIITGIVLL 108
Cdd:COG0697   63 RDWLLLLLRGLLGLALAFLLFFLALQYTPAALAALLLALAPLFVALLAALLLGERLSRRRWLGLLLGFAGVLLI 136
RibN COG2510
Riboflavin transporter RibN, EamA domain [Coenzyme transport and metabolism];
39-108 5.18e-05

Riboflavin transporter RibN, EamA domain [Coenzyme transport and metabolism];


Pssm-ID: 442000  Cd Length: 138  Bit Score: 39.78  E-value: 5.18e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521291339  39 LWLGLALMALGAGMALWLLVLQRIPVGVAYPMLSLNFVWVTLAARFLWREPVSVRHAFGVALIITGIVLL 108
Cdd:COG2510   66 LFLLLSGLATGLSWLFYFRALKLGPASIVAPIDKLSPVFTVLLSVLFLGERLTLKQIIGILLIVAGVILL 135
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
 41-108 1.34e-04

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 38.33  E-value: 1.34e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 521291339   41 LGLALMALGAGMALWLLVLQRIPVGVAYPMLSLNFVWVTLAARFLWREPVSVRHAFGVALIITGIVLL 108
Cdd:pfam00892  67 LYLGVLGTFLGFLLYFYGLKYVSASNASVITSLSPVFTLILSVLLLGEKLTLKQLLGIVLILLGVLLI 134
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
 36-108 2.60e-04

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 38.67  E-value: 2.60e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 521291339  36 HLGLWLGLALMALGAGMALWLLVLQRIPVGVAYPMLSLNFVWVTLAARFLWREPVSVRHAFGVALIITGIVLL 108
Cdd:COG0697  209 AWLALLYLGLFGTALAYLLWFRALRRLGASRAAPLTYLEPVFAVLLGWLLLGEPLTPLQLLGAALILAGVLLA 281
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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