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Conserved domains on  [gi|521074044|ref|WP_020404951|]
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pyrimidine/purine nucleoside phosphorylase [Hahella ganghwensis]

Protein Classification

pyrimidine/purine nucleoside phosphorylase( domain architecture ID 10006942)

pyrimidine/purine nucleoside phosphorylase catalyzes the phosphorolysis of diverse nucleosides, such as uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine, yielding D-ribose 1-phosphate and the respective free bases; also catalyzes the reverse reactions

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PpnP COG3123
Pyrimidine/purine nucleoside phosphorylase YaiE/PpnP, UPF0345/DUF1255 family [Nucleotide ...
1-91 3.56e-55

Pyrimidine/purine nucleoside phosphorylase YaiE/PpnP, UPF0345/DUF1255 family [Nucleotide transport and metabolism];


:

Pssm-ID: 442357  Cd Length: 99  Bit Score: 165.72  E-value: 3.56e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521074044  1 MFDVNEYFDGKVKSIAFQTET-LPATVGVMAPGEYEFGTSQHETMTVVSGELTARLPQQEEWQSFTPGQSFEVPANSKFQ 79
Cdd:COG3123   8 MKKANVYFDGKVKSRTFIFADgSKKTLGVMLPGEYTFGTGAPEIMEVVSGELEVKLPGSDEWQTYAAGESFEVPANSSFD 87
                        90
                ....*....|..
gi 521074044 80 LKVSVDTAYLCT 91
Cdd:COG3123  88 LKVAEPTAYLCS 99
 
Name Accession Description Interval E-value
PpnP COG3123
Pyrimidine/purine nucleoside phosphorylase YaiE/PpnP, UPF0345/DUF1255 family [Nucleotide ...
1-91 3.56e-55

Pyrimidine/purine nucleoside phosphorylase YaiE/PpnP, UPF0345/DUF1255 family [Nucleotide transport and metabolism];


Pssm-ID: 442357  Cd Length: 99  Bit Score: 165.72  E-value: 3.56e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521074044  1 MFDVNEYFDGKVKSIAFQTET-LPATVGVMAPGEYEFGTSQHETMTVVSGELTARLPQQEEWQSFTPGQSFEVPANSKFQ 79
Cdd:COG3123   8 MKKANVYFDGKVKSRTFIFADgSKKTLGVMLPGEYTFGTGAPEIMEVVSGELEVKLPGSDEWQTYAAGESFEVPANSSFD 87
                        90
                ....*....|..
gi 521074044 80 LKVSVDTAYLCT 91
Cdd:COG3123  88 LKVAEPTAYLCS 99
Ppnp pfam06865
Pyrimidine/purine nucleoside phosphorylase; This family consist of YaiE and related proteins. ...
2-92 3.68e-54

Pyrimidine/purine nucleoside phosphorylase; This family consist of YaiE and related proteins. YaiE from E. coli catalyzes phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and free bases.


Pssm-ID: 462023  Cd Length: 92  Bit Score: 163.04  E-value: 3.68e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521074044   2 FDVNEYFDGKVKSIAFQTET-LPATVGVMAPGEYEFGTSQHETMTVVSGELTARLPQQEEWQSFTPGQSFEVPANSKFQL 80
Cdd:pfam06865  1 KKANVYFDGKVTSRTFEFADgSKKTLGVMLPGEYTFGTGAPEIMEVVSGELEVKLPGSDEWKTYAAGESFEVPANSSFDL 80
                         90
                 ....*....|..
gi 521074044  81 KVSVDTAYLCTY 92
Cdd:pfam06865 81 KVKEVTDYLCSY 92
cupin_PpnP-like cd20296
pyrimidine/purine nucleoside phosphorylase and related proteins, cupin domain; This family ...
4-92 1.58e-44

pyrimidine/purine nucleoside phosphorylase and related proteins, cupin domain; This family includes cupin domain proteins that are homologous to pyrimidine/purine nucleoside phosphorylase PpnP. Purine and pyrimidine nucleoside phosphorylases are key enzymes of the nucleoside salvage pathway; they catalyze the reversible phosphorolytic cleavage of the glycosidic bond of purine and pyrimidine nucleosides. Nucleoside phosphorylases are of medical interest since phosphorylases can be used in activating prodrugs; high-molecular mass purine nucleoside phosphorylases may be used in gene therapy of some solid tumors and their inhibitors could be selective immunosuppressive, anticancer, and antiparasitic agents. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380430  Cd Length: 90  Bit Score: 138.48  E-value: 1.58e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521074044  4 VNEYFDGKVKSIAFQTE-TLPATVGVMAPGEYEFGTSQHETMTVVSGELTARLPQQEEWQSFTPGQSFEVPANSKFQLKV 82
Cdd:cd20296   1 ANVYFDGKVKSRTVIFAdGSKKTLGVMLPGEYTFGTEAPERMEIISGECRVKLPGETDWQTYSAGESFEVPANSSFKIEV 80
                        90
                ....*....|
gi 521074044 83 SVDTAYLCTY 92
Cdd:cd20296  81 KEVTDYLCSY 90
PRK10579 PRK10579
pyrimidine/purine nucleoside phosphorylase;
1-92 8.19e-37

pyrimidine/purine nucleoside phosphorylase;


Pssm-ID: 182565  Cd Length: 94  Bit Score: 119.13  E-value: 8.19e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521074044  1 MFDVNEYFDGKVKSIAFQTETL-PATVGVMAPGEYEFGTSQHETMTVVSGELTARLPQQEEWQSFTPGQSFEVPANSKFQ 79
Cdd:PRK10579  1 MLQSNEYFSGKVKSIGFDSSSTgRASVGVMAEGEYTFSTAEPEEMTVISGALNVLLPGATDWQVYEAGEVFNVPGHSEFH 80
                        90
                ....*....|...
gi 521074044 80 LKVSVDTAYLCTY 92
Cdd:PRK10579 81 LQVAEPTSYLCRY 93
 
Name Accession Description Interval E-value
PpnP COG3123
Pyrimidine/purine nucleoside phosphorylase YaiE/PpnP, UPF0345/DUF1255 family [Nucleotide ...
1-91 3.56e-55

Pyrimidine/purine nucleoside phosphorylase YaiE/PpnP, UPF0345/DUF1255 family [Nucleotide transport and metabolism];


Pssm-ID: 442357  Cd Length: 99  Bit Score: 165.72  E-value: 3.56e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521074044  1 MFDVNEYFDGKVKSIAFQTET-LPATVGVMAPGEYEFGTSQHETMTVVSGELTARLPQQEEWQSFTPGQSFEVPANSKFQ 79
Cdd:COG3123   8 MKKANVYFDGKVKSRTFIFADgSKKTLGVMLPGEYTFGTGAPEIMEVVSGELEVKLPGSDEWQTYAAGESFEVPANSSFD 87
                        90
                ....*....|..
gi 521074044 80 LKVSVDTAYLCT 91
Cdd:COG3123  88 LKVAEPTAYLCS 99
Ppnp pfam06865
Pyrimidine/purine nucleoside phosphorylase; This family consist of YaiE and related proteins. ...
2-92 3.68e-54

Pyrimidine/purine nucleoside phosphorylase; This family consist of YaiE and related proteins. YaiE from E. coli catalyzes phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and free bases.


Pssm-ID: 462023  Cd Length: 92  Bit Score: 163.04  E-value: 3.68e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521074044   2 FDVNEYFDGKVKSIAFQTET-LPATVGVMAPGEYEFGTSQHETMTVVSGELTARLPQQEEWQSFTPGQSFEVPANSKFQL 80
Cdd:pfam06865  1 KKANVYFDGKVTSRTFEFADgSKKTLGVMLPGEYTFGTGAPEIMEVVSGELEVKLPGSDEWKTYAAGESFEVPANSSFDL 80
                         90
                 ....*....|..
gi 521074044  81 KVSVDTAYLCTY 92
Cdd:pfam06865 81 KVKEVTDYLCSY 92
cupin_PpnP-like cd20296
pyrimidine/purine nucleoside phosphorylase and related proteins, cupin domain; This family ...
4-92 1.58e-44

pyrimidine/purine nucleoside phosphorylase and related proteins, cupin domain; This family includes cupin domain proteins that are homologous to pyrimidine/purine nucleoside phosphorylase PpnP. Purine and pyrimidine nucleoside phosphorylases are key enzymes of the nucleoside salvage pathway; they catalyze the reversible phosphorolytic cleavage of the glycosidic bond of purine and pyrimidine nucleosides. Nucleoside phosphorylases are of medical interest since phosphorylases can be used in activating prodrugs; high-molecular mass purine nucleoside phosphorylases may be used in gene therapy of some solid tumors and their inhibitors could be selective immunosuppressive, anticancer, and antiparasitic agents. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380430  Cd Length: 90  Bit Score: 138.48  E-value: 1.58e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521074044  4 VNEYFDGKVKSIAFQTE-TLPATVGVMAPGEYEFGTSQHETMTVVSGELTARLPQQEEWQSFTPGQSFEVPANSKFQLKV 82
Cdd:cd20296   1 ANVYFDGKVKSRTVIFAdGSKKTLGVMLPGEYTFGTEAPERMEIISGECRVKLPGETDWQTYSAGESFEVPANSSFKIEV 80
                        90
                ....*....|
gi 521074044 83 SVDTAYLCTY 92
Cdd:cd20296  81 KEVTDYLCSY 90
PRK10579 PRK10579
pyrimidine/purine nucleoside phosphorylase;
1-92 8.19e-37

pyrimidine/purine nucleoside phosphorylase;


Pssm-ID: 182565  Cd Length: 94  Bit Score: 119.13  E-value: 8.19e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 521074044  1 MFDVNEYFDGKVKSIAFQTETL-PATVGVMAPGEYEFGTSQHETMTVVSGELTARLPQQEEWQSFTPGQSFEVPANSKFQ 79
Cdd:PRK10579  1 MLQSNEYFSGKVKSIGFDSSSTgRASVGVMAEGEYTFSTAEPEEMTVISGALNVLLPGATDWQVYEAGEVFNVPGHSEFH 80
                        90
                ....*....|...
gi 521074044 80 LKVSVDTAYLCTY 92
Cdd:PRK10579 81 LQVAEPTSYLCRY 93
cupin_Mj0764-like cd20290
uncharacterized Methanocaldococcus jannaschii Mj0764 and related proteins, cupin domain; This ...
28-81 5.41e-04

uncharacterized Methanocaldococcus jannaschii Mj0764 and related proteins, cupin domain; This family includes archaeal and bacterial proteins homologous to MJ0764, a Methanocaldococcus jannaschii protein of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380424 [Multi-domain]  Cd Length: 100  Bit Score: 35.64  E-value: 5.41e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 521074044  28 VMAPGEyefGTSQHET-----MTVVSGELTARLPQQEEWQsFTPGQSFEVPANSKFQLK 81
Cdd:cd20290   29 ILNPGQ---ALPEHNAnsnvyMTVVRGTLTLTLEDQETHK-YEAGTILKIPFNTKMNIK 83
cupin_TcmJ-like cd06991
TcmJ monooxygenase and related proteins, cupin domain; This family includes TcmJ, a subunit of ...
23-73 2.08e-03

TcmJ monooxygenase and related proteins, cupin domain; This family includes TcmJ, a subunit of the tetracenomycin (TCM) polyketide synthase (PKS) type II complex in Streptomyces glaucescens. TcmJ is a quinone-forming monooxygenase involved in the modification of aromatic polyketides synthesized by polyketide synthases of types II and III. Orthologs of TcmJ include the Streptomyces BenD (benastatin biosynthetic pathway), the Streptomyces olivaceus ElmJ (polyketide antibiotic elloramycin biosynthetic pathway), the Actinomadura hibisca PdmL (pradimicin biosynthetic pathway), the Streptomyces cyaneus CurC (curamycin biosynthetic pathway), the Streptomyces rishiriensis Lct30 (lactonamycin biosynthetic pathway), and the Streptomyces WhiE II (spore pigment polyketide biosynthetic pathway). Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380396 [Multi-domain]  Cd Length: 105  Bit Score: 34.19  E-value: 2.08e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 521074044  23 PATVG---------VMAPGEYefgTSQH------ETMTVVSGELTARLpqQEEWQSFTPGQSFEVP 73
Cdd:cd06991   11 PKTVGatsgfmgtlTLAPGER---VSEHyhpyseEFLYVVRGRLVVRV--DGEPVVLEAGEALLVP 71
COG3450 COG3450
Predicted enzyme of the cupin superfamily [General function prediction only];
15-77 4.39e-03

Predicted enzyme of the cupin superfamily [General function prediction only];


Pssm-ID: 442673  Cd Length: 108  Bit Score: 33.42  E-value: 4.39e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 521074044  15 IAFQTETLPATVGV--MAPGEYEFGTSQHETMTVVSGELTARlPQQEEWQSFTPGQSFEVPANSK 77
Cdd:COG3450   29 NLFTSPDGGVSAGVweCTPGKFRWDYDEDEFCYILEGRVTVT-DDDGEPVEFGAGDSFVFPAGFK 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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