|
Name |
Accession |
Description |
Interval |
E-value |
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
1-432 |
0e+00 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 871.25 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 1 MVERLTWKKLAWELAFFYLPWIVVGWIFGYMPWLLLAATALQLVWHLHNQMRLSAWLWDEKRLTPPSGSGNWEYLFNGIY 80
Cdd:PRK11006 1 MLERLSWKRLVLELALFCLPALILGAFFGYLPWFLLASVTGLLIWHFWNLLRLSWWLWVDRSMTPPPGRGSWEPLFYGLY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 81 RLQQRQRKKRKELTNLIRRFRNGAESLPDAVVVFRSEGNIVWCNRLAQHLLGFRWPDDAGQPISNLIRTPDFIKYLQKDD 160
Cdd:PRK11006 81 QMQLRNRKRRRELGNLIKRFRSGAESLPDAVVLTTEEGNIFWCNGLAQQLLGFRWPEDNGQNILNLLRYPEFTQYLKTRD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 161 FTEPLEMrsPLNVERSLELRIVPYTEGEHLMVVRDVTQLKQLEGMRRNFFANVSHELRTPMTVLQGYLEMTEDPDMlVGP 240
Cdd:PRK11006 161 FSRPLTL--VLNNGRHLEIRVMPYTEGQLLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQDQPL-EGA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 241 MWGKAHGVMTEQLNRMNSLVNQLLTLSKIEASPMHELEDVVDVPAMLEVLEKEAISLSgDDKHQLKFDIDKQLRVLADED 320
Cdd:PRK11006 238 LREKALHTMREQTQRMEGLVKQLLTLSKIEAAPTIDLNEKVDVPMMLRVLEREAQTLS-QGKHTITFEVDNSLKVFGNED 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 321 QLRSAISNLVYNAVKYTPPGAEINVRWFQTPQGACLEVEDKGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKH 400
Cdd:PRK11006 317 QLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKH 396
|
410 420 430
....*....|....*....|....*....|..
gi 520910886 401 ALSHHDSHLDIKSTVGVGSRFSFVLPKRLVVK 432
Cdd:PRK11006 397 ALSHHDSRLEIESEVGKGTRFSFVLPERLIAK 428
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
93-425 |
0e+00 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 531.78 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 93 LTNLIRRFRNGAESLPDAVVVFRSEGNIVWCNRLAQHLLGFRWPDDAGQPISNLIRTPDFIKYLQKDDFTEPLEMRSPLN 172
Cdd:TIGR02966 1 LSALLSRFRAAAQALPDAVVVLDEEGQIEWCNPAAERLLGLRWPDDLGQRITNLIRHPEFVEYLAAGRFSEPLELPSPIN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 173 VERSLELRIVPYTEGEHLMVVRDVTQLKQLEGMRRNFFANVSHELRTPMTVLQGYLEMTEDPDMLVGPMWGKAHGVMTEQ 252
Cdd:TIGR02966 81 SERVLEIRIAPYGEEQKLLVARDVTRLRRLEQMRRDFVANVSHELRTPLTVLRGYLETLADGPDEDPEEWNRALEIMLEQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 253 LNRMNSLVNQLLTLSKIEASPMHELEDVVDVPAMLEVLEKEAISLSGDDKHQLKFDIDKQLRVLADEDQLRSAISNLVYN 332
Cdd:TIGR02966 161 SQRMQSLVEDLLTLSRLESAASPLEDEPVDMPALLDHLRDEAEALSQGKNHQITFEIDGGVDVLGDEDELRSAFSNLVSN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 333 AVKYTPPGAEINVRWFQTPQGACLEVEDKGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALSHHDSHLDIK 412
Cdd:TIGR02966 241 AIKYTPEGGTITVRWRRDGGGAEFSVTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHARLEIE 320
|
330
....*....|...
gi 520910886 413 STVGVGSRFSFVL 425
Cdd:TIGR02966 321 SELGKGSTFSFIF 333
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
75-428 |
2.16e-97 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 296.85 E-value: 2.16e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 75 LFNGIYRLQQRQRKKRKELTNLIRRFRNGAESLPDAVVVFRSEGNIVWCNRLAQHLLGFRWPDDAGQPISNLIRTPDFIK 154
Cdd:COG5002 34 LLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLIL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 155 YLQKDDFTEPLEMRSPLNVERSLELRIVPYTEGEHLMVVRDVTQLKQLEGMRRNFFANVSHELRTPMTVLQGYLEMTEDP 234
Cdd:COG5002 114 LAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDG 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 235 DMLVGPMWGKAHGVMTEQLNRMNSLVNQLLTLSKIEASPMHELEDVVDVPAMLEVLEKEAISLSGDDKHQLKFDI-DKQL 313
Cdd:COG5002 194 AADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLpEDPL 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 314 RVLADEDQLRSAISNLVYNAVKYTPPGAEINVRWFQTPQGACLEVEDKGDGIEPQHLHRLTERFYRVDKARSRDTGGSGL 393
Cdd:COG5002 274 LVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGL 353
|
330 340 350
....*....|....*....|....*....|....*
gi 520910886 394 GLAIVKHALSHHDSHLDIKSTVGVGSRFSFVLPKR 428
Cdd:COG5002 354 GLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLA 388
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
194-428 |
2.70e-66 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 211.69 E-value: 2.70e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 194 RDVTQLKQLEGMRRNFFANVSHELRTPMTVLQGYLEMTEDPDMLVGPMWGKAHGVMTEQLNRMNSLVNQLLTLSKIEASP 273
Cdd:COG2205 4 EALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLESGK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 274 MHELEDVVDVPAMLEVLEKEAISLSGDDKHQLKFDIDKQL-RVLADEDQLRSAISNLVYNAVKYTPPGAEINVRWFQTPQ 352
Cdd:COG2205 84 LSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELpLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREGD 163
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 520910886 353 GACLEVEDKGDGIEPQHLHRLTERFYRVDkaRSRDTGGSGLGLAIVKHALSHHDSHLDIKSTVGVGSRFSFVLPKR 428
Cdd:COG2205 164 GVRISVSDNGPGIPEEELERIFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLA 237
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
125-428 |
3.50e-66 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 214.39 E-value: 3.50e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 125 RLAQHLLGFRWPDDAGQPISNLIRTPDFIKYLQKDDFTEPLEMRSPLNVERSLELRIVPYTEGEHLMVVRDVTQ---LKQ 201
Cdd:COG0642 26 LLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALlllLEE 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 202 LEGMRRNFFANVSHELRTPMTVLQGYLEMTEDPdmlVGPMWGKAHGVMTEQLNRMNSLVNQLLTLSKIEASPMHELEDVV 281
Cdd:COG0642 106 ANEAKSRFLANVSHELRTPLTAIRGYLELLLEE---LDEEQREYLETILRSADRLLRLINDLLDLSRLEAGKLELEPEPV 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 282 DVPAMLEVLEKEAISLSGDDKHQLKFDIDKQL-RVLADEDQLRSAISNLVYNAVKYTPPGAEINVRWFQTPQGACLEVED 360
Cdd:COG0642 183 DLAELLEEVVELFRPLAEEKGIELELDLPDDLpTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISVED 262
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 520910886 361 KGDGIEPQHLHRLTERFYRVDkaRSRDTGGSGLGLAIVKHALSHHDSHLDIKSTVGVGSRFSFVLPKR 428
Cdd:COG0642 263 TGPGIPPEDLERIFEPFFRTD--PSRRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPLA 328
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-429 |
9.36e-56 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 179.71 E-value: 9.36e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 322 LRSAISNLVYNAVKYTPPGAEINVRWFQTPQGACLEVEDKGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHA 401
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHV 80
|
90 100
....*....|....*....|....*...
gi 520910886 402 LSHHDSHLDIKSTVGVGSRFSFVLPKRL 429
Cdd:cd16952 81 MSRHDARLLIASELGKGSRFTCLFPSSR 108
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
76-427 |
2.02e-54 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 186.71 E-value: 2.02e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 76 FNgiyRLQQRQRKKRKELTNLIRRFRNGAESLPDAVVVFRSEGNIVWCNRLAQHLLGFRWPDDAGQPISNLIRTPDFIKY 155
Cdd:COG5000 71 FN---RMTDQLKEQREELEERRRYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGKPLEELLPELDLAEL 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 156 LQKD-DFTEPLEMRSPLNVERSLELRIVPYTEGEHLMVVRDVTQLKQLEGM-------RRnffanVSHELRTPMTVLQGY 227
Cdd:COG5000 148 LREAlERGWQEEIELTRDGRRTLLVRASPLRDDGYVIVFDDITELLRAERLaawgelaRR-----IAHEIKNPLTPIQLS 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 228 LE---------MTEDPDMLVgpmwgKAHGVMTEQLNRMNSLVNQLLTLSKIeasPMHELEDVvDVPAMLEvlekEAISL- 297
Cdd:COG5000 223 AErlrrkladkLEEDREDLE-----RALDTIIRQVDRLKRIVDEFLDFARL---PEPQLEPV-DLNELLR----EVLALy 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 298 -SGDDKHQLKFDID---KQLRVLADEDQLRSAISNLVYNAVKYTPPGAEINVRWFQTPQGACLEVEDKGDGIEPQHLHRL 373
Cdd:COG5000 290 ePALKEKDIRLELDldpDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERI 369
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 520910886 374 TERFYrvdkarSRDTGGSGLGLAIVKHALSHHDSHLDIKSTVGVGSRFSFVLPK 427
Cdd:COG5000 370 FEPFF------TTKPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPL 417
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
56-429 |
9.37e-52 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 180.94 E-value: 9.37e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 56 WLWDEKRLTP-PSGSGNWEYLFnGIYRLQQRQRKKRKELTNLIRRFRNGAESLPDAVVVFRSEGNIVWCNRLAQHLLGFR 134
Cdd:COG5809 99 RLEFSSKLSPiFDQNGDIEGML-AISRDITERKRMEEALRESEEKFRLIFNHSPDGIIVTDLDGRIIYANPAACKLLGIS 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 135 WPDDAGQPISNLIRTPD------FIKYLQKDDFTEPLEMRSPLNVERS--LELRIVPYTEGEH----LMVVRDVTQLKQL 202
Cdd:COG5809 178 IEELIGKSILELIHSDDqenvaaFISQLLKDGGIAQGEVRFWTKDGRWrlLEASGAPIKKNGEvdgiVIIFRDITERKKL 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 203 E-GMRRN--------FFANVSHELRTPMTVLQGYLEMTEDPDMLVGPMWgkaHGVMTEQLNRMNSLVNQLLTLSKIEASP 273
Cdd:COG5809 258 EeLLRKSeklsvvgeLAAGIAHEIRNPLTSLKGFIQLLKDTIDEEQKTY---LDIMLSELDRIESIISEFLVLAKPQAIK 334
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 274 MHE------LEDVVDvpamleVLEKEAISlsgdDKHQLKFDIDKQL-RVLADEDQLRSAISNLVYNAVKYTPPGAEINVR 346
Cdd:COG5809 335 YEPkdlntlIEEVIP------LLQPQALL----KNVQIELELEDDIpDILGDENQLKQVFINLLKNAIEAMPEGGNITIE 404
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 347 WFQTPQGAC-LEVEDKGDGIEPQHLHRLTERFYrvdkarSRDTGGSGLGLAIVKHALSHHDSHLDIKSTVGVGSRFSFVL 425
Cdd:COG5809 405 TKAEDDDKVvISVTDEGCGIPEERLKKLGEPFY------TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITL 478
|
....
gi 520910886 426 PKRL 429
Cdd:COG5809 479 PIKL 482
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
92-426 |
1.74e-47 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 166.56 E-value: 1.74e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 92 ELTNLIRRFRNGAESLPDAVVVFRSEGNIVWCNRLAQHLLGFRWPDDAGQPISNLIRTPD-FIKYLQK-----DDFTEP- 164
Cdd:COG3852 1 ALRESEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFPEDSpLRELLERalaegQPVTERe 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 165 LEMRSPLNVERSLELRIVPYTEGEH----LMVVRDVTQLKQLEG-MRRN--------FFANVSHELRTPMTVLQGYLEM- 230
Cdd:COG3852 81 VTLRRKDGEERPVDVSVSPLRDAEGeggvLLVLRDITERKRLEReLRRAeklaavgeLAAGLAHEIRNPLTGIRGAAQLl 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 231 ------TEDPDMLvgpmwgkahGVMTEQLNRMNSLVNQLLTLSKIEASPM--HELEDVVDvpAMLEVLEKEAislsgDDK 302
Cdd:COG3852 161 erelpdDELREYT---------QLIIEEADRLNNLVDRLLSFSRPRPPERepVNLHEVLE--RVLELLRAEA-----PKN 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 303 HQLKFDIDKQL-RVLADEDQLRSAISNLVYNAVKYTPPGAEINVRWFQTPQG----------ACLEVEDKGDGIEPQHLH 371
Cdd:COG3852 225 IRIVRDYDPSLpEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVERQVtlgglrprlyVRIEVIDNGPGIPEEILD 304
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 520910886 372 RLTERFYrvdkarSRDTGGSGLGLAIVKHALSHHDSHLDIKSTVGVGSRFSFVLP 426
Cdd:COG3852 305 RIFEPFF------TTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLP 353
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
118-426 |
9.64e-47 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 169.55 E-value: 9.64e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 118 GNIVWCNRLAQHLLGFRWPDDAGQPISNLIRTPDfikylqkdDFTEP--LEMRSPLNVERSlelrivpyTEGEHLM---- 191
Cdd:NF033092 278 GRVILINDPALEMLNVSRETVLGQSILDVLGLEE--------EYTLRdlLEEQDSLLLDFS--------TEEEPLIlran 341
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 192 ----------------VVRDVTQLKQLEGMRRNFFANVSHELRTPMTVLQGYLEMT-----EDPDmlVGPmwgKAHGVMT 250
Cdd:NF033092 342 fsviqresgfingliaVLHDVTEQEKIEQERREFVANVSHELRTPLTTMRSYLEALadgawKDPE--LAP---RFLGVTQ 416
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 251 EQLNRMNSLVNQLLTLSKIEASPMHELEDVVDVPAML-EVLEKEAISLSgDDKHQLKFDIDKQ-LRVLADEDQLRSAISN 328
Cdd:NF033092 417 NETERMIRLVNDLLQLSRMDSKDYKLNKEWVNFNEFFnYIIDRFEMILK-NKNITFKREFPKRdLWVEIDTDKITQVLDN 495
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 329 LVYNAVKYTPPGAEINVRWFQTPQGACLEVEDKGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALSHHDSH 408
Cdd:NF033092 496 IISNAIKYSPEGGTITFRLLETHNRIIISISDQGLGIPKKDLDKIFDRFYRVDKARSRKMGGTGLGLAIAKEVVEAHGGR 575
|
330
....*....|....*...
gi 520910886 409 LDIKSTVGVGSRFSFVLP 426
Cdd:NF033092 576 IWAESEEGKGTTIYFTLP 593
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
57-427 |
2.01e-38 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 145.26 E-value: 2.01e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 57 LWDEKRLTPPSGSGNWE--YLFNGIY---RLQQRQRKKRKELTNLIrrfrngaESLPDAVVVFRSEGNIVWCNRLAQHLL 131
Cdd:COG5805 118 IYVEVKLFPIYNQNGQAaiLALRDITkkkKIEEILQEQEERLQTLI-------ENSPDLICVIDTDGRILFINESIERLF 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 132 GFRWPDDAGQPISNLIRTPD---FIKYLQKDdftEPLEMRSPLNVE--------RSLELRIVPY--TEGEH---LMVVRD 195
Cdd:COG5805 191 GAPREELIGKNLLELLHPCDkeeFKERIESI---TEVWQEFIIEREiitkdgriRYFEAVIVPLidTDGSVkgiLVILRD 267
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 196 VTQLKQLEGMRRNF---------FANVSHELRTPMTVLQGYLEMtedpdMLVGPMWGKAHG-VMTEQLNRMNSLVNQLLT 265
Cdd:COG5805 268 ITEKKEAEELMARSeklsiagqlAAGIAHEIRNPLTSIKGFLQL-----LQPGIEDKEEYFdIMLSELDRIESIISEFLA 342
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 266 LSKIEA------SPMHELEDVVdvpaMLevLEKEAISlsgDDKHQLKFDIDKQLRVLADEDQLRSAISNLVYNAVKYTPP 339
Cdd:COG5805 343 LAKPQAvnkekeNINELIQDVV----TL--LETEAIL---HNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPN 413
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 340 GAEINVRWFQTPQGACLEVEDKGDGIEPQHLHRLTERFYrvdkarSRDTGGSGLGLAIVKHALSHHDSHLDIKSTVGVGS 419
Cdd:COG5805 414 GGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFF------TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGT 487
|
....*...
gi 520910886 420 RFSFVLPK 427
Cdd:COG5805 488 TFTITLPL 495
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
105-428 |
4.99e-36 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 139.72 E-value: 4.99e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 105 ESLPDAVVVFRSEGNIVWCNRLAQHLLGFRWPDDAGQPISNL-IRTPDFIKY----LQKDDFTEPLEMRSPlNVERSLEL 179
Cdd:PRK11360 269 ESIADGVIAIDRQGKITTMNPAAEVITGLQRHELVGKPYSELfPPNTPFASPlldtLEHGTEHVDLEISFP-GRDRTIEL 347
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 180 ----RIVPYTEGE---HLMVVRDVTQLKQL-EGMRR--------NFFANVSHELRTPMTVLQGYLEMTEDPDMlvGPMWG 243
Cdd:PRK11360 348 svstSLLHNTHGEmigALVIFSDLTERKRLqRRVARqerlaalgELVAGVAHEIRNPLTAIRGYVQIWRQQTS--DPPSQ 425
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 244 KAHGVMTEQLNRMNSLVNQLLTLSKieasPMHELEDVVDVPAMLE---VLEKEAIslsGDDKHQLKFDIDKQL-RVLADE 319
Cdd:PRK11360 426 EYLSVVLREVDRLNKVIDQLLEFSR----PRESQWQPVSLNALVEevlQLFQTAG---VQARVDFETELDNELpPIWADP 498
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 320 DQLRSAISNLVYNAVKYTPPGAEINVR-WFQTPQGACLEVEDKGDGIEPQHLHRLTERFYRVdKARsrdtgGSGLGLAIV 398
Cdd:PRK11360 499 ELLKQVLLNILINAVQAISARGKIRIRtWQYSDGQVAVSIEDNGCGIDPELLKKIFDPFFTT-KAK-----GTGLGLALS 572
|
330 340 350
....*....|....*....|....*....|
gi 520910886 399 KHALSHHDSHLDIKSTVGVGSRFSFVLPKR 428
Cdd:PRK11360 573 QRIINAHGGDIEVESEPGVGTTFTLYLPIN 602
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
180-405 |
1.91e-34 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 133.41 E-value: 1.91e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 180 RIVPYTEGEHLMVVRDVTQLKQL----EGMRRNFFANVSHELRTPMTVLQGYLEMTED------PDMLVGpmwgkahgvM 249
Cdd:NF012163 210 RVTPTSNDELGKLAQDFNQLASTleknEQMRRDFMADISHELRTPLAVLRAELEAIQDgirkftPESLDS---------L 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 250 TEQLNRMNSLVNQLLTLSKIEASPMHELEDVVDVPAMLEVlEKEAISLSGDDKH-QLKFDIDKQLRVLADEDQLRSAISN 328
Cdd:NF012163 281 QAEVGTLTKLVDDLHDLSMSDEGALAYQKASVDLVPLLEV-EGGAFRERFASAGlELEVSLPDSSLVFGDRDRLMQLFNN 359
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 520910886 329 LVYNAVKYTPPGAEINVRWFQTPQGACLEVEDKGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAI-VKHALSHH 405
Cdd:NF012163 360 LLENSLRYTDSGGSLHISASQRPKEVTLTVADSAPGVSDEQLARLFERFYRVEVSRNRASGGSGLGLAIsLNIVQAHG 437
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
199-426 |
5.07e-34 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 132.13 E-value: 5.07e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 199 LKQLE-GMRR--NFFANVSHELRTPMTVLqgyleMTEDPDMLVGPMWGKAHGVMT----EQLNRMNSLVNQLLTLSKIEA 271
Cdd:TIGR01386 231 LGRLEdAFQRlsQFSADLAHELRTPLTNL-----LGQTQVALSQPRTGEEYREVLesnlEELERLSRMVSDMLFLARADN 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 272 SPMH----------ELEDVVDVpamLEVLEKEA---ISLSGDdkhqlkfdidkqLRVLADEDQLRSAISNLVYNAVKYTP 338
Cdd:TIGR01386 306 GQLAlervrldlaaELAKVAEY---FEPLAEERgvrIRVEGE------------GLVRGDPQMFRRAISNLLSNALRHTP 370
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 339 PGAEINVRWFQTPQGACLEVEDKGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALSHHDSHLDIKSTVGvG 418
Cdd:TIGR01386 371 DGGTITVRIERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDG-K 449
|
....*...
gi 520910886 419 SRFSFVLP 426
Cdd:TIGR01386 450 TRFILRFP 457
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
210-428 |
6.33e-34 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 132.60 E-value: 6.33e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 210 FAN-VSHELRTPMTVLQGYLEMTE-------DPDmlvgpmwGKAH-GVMTEQLNRMNSLVNQLLTLSKIEASPMHEleDV 280
Cdd:COG4251 285 FAYvASHDLREPLRKISGFSQLLEedygdklDEE-------GREYlERIRDAAERMQALIDDLLAYSRVGRQELEF--EP 355
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 281 VDVPAML-EVLEKEAISLSGddkHQLKFDIDKQLRVLADEDQLRSAISNLVYNAVKYTPPG--AEINVRWFQTPQGACLE 357
Cdd:COG4251 356 VDLNELLeEVLEDLEPRIEE---RGAEIEVGPLPTVRGDPTLLRQVFQNLISNAIKYSRPGepPRIEIGAEREGGEWVFS 432
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 520910886 358 VEDKGDGIEPQHLHRLTERFYRVDkaRSRDTGGSGLGLAIVKHALSHHDSHLDIKSTVGVGSRFSFVLPKR 428
Cdd:COG4251 433 VRDNGIGIDPEYAEKIFEIFQRLH--SRDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPKA 501
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
317-428 |
1.28e-33 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 121.99 E-value: 1.28e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 317 ADEDQLRSAISNLVYNAVKYTPPGAEINVRWFQTPQGACLEVEDKGDGIEPQHLHRLTERFYRVDKaRSRDTGGSGLGLA 396
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|..
gi 520910886 397 IVKHALSHHDSHLDIKSTVGVGSRFSFVLPKR 428
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGGTTFTITLPLE 111
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
208-428 |
1.11e-31 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 126.04 E-value: 1.11e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 208 NFFANVSHELRTPMTVLQGYLEMT--------EDPDMLVGPMwgkahgvmtEQLNRMNSLVNQLLTLSKIEASPMHELED 279
Cdd:PRK09835 264 NFSADIAHEIRTPITNLITQTEIAlsqsrsqkELEDVLYSNL---------EELTRMAKMVSDMLFLAQADNNQLIPEKK 334
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 280 VVDVPA-MLEVLEK-EAISlsgDDKH-QLKFDiDKQLRVLADEDQLRSAISNLVYNAVKYTPPGAEINVRWFQTPQGACL 356
Cdd:PRK09835 335 MLDLADeVGKVFDFfEAWA---EERGvELRFV-GDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQL 410
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 520910886 357 EVEDKGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALSHHDSHLDIKSTVgVGSRFSFVLPKR 428
Cdd:PRK09835 411 VVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDA-RGTRFVISLPRL 481
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
211-426 |
1.51e-28 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 115.28 E-value: 1.51e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 211 ANVSHELRTPMTVLQGYLEMTED--PDMLVGPMWGKAHGVMTEQLNRMNSLVNQLLTLSKIEASPMHE--LEDVVDvpAM 286
Cdd:COG4191 147 AGIAHEINNPLAAILGNAELLRRrlEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRDEEEREPvdLNELID--EA 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 287 LEVLEKEAislsGDDKHQLKFDIDKQL-RVLADEDQLRSAISNLVYNAVKYTPPGA--EINVRWFQTPQGACLEVEDKGD 363
Cdd:COG4191 225 LELLRPRL----KARGIEVELDLPPDLpPVLGDPGQLEQVLLNLLINAIDAMEEGEggRITISTRREGDYVVISVRDNGP 300
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 520910886 364 GIEPQHLHRLTERFY---RVDKarsrdtgGSGLGLAIVKHALSHHDSHLDIKSTVGVGSRFSFVLP 426
Cdd:COG4191 301 GIPPEVLERIFEPFFttkPVGK-------GTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLP 359
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
317-428 |
2.22e-28 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 107.84 E-value: 2.22e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 317 ADEDQLRSAISNLVYNAVKYTPPGAEINVRwFQTPQGACLEVEDKGDGIEPQHLHRLTERFYRVDKarsRDTGGSGLGLA 396
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVT-LSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGLS 76
|
90 100 110
....*....|....*....|....*....|..
gi 520910886 397 IVKHALSHHDSHLDIKSTVGVGSRFSFVLPKR 428
Cdd:pfam02518 77 IVRKLVELLGGTITVESEPGGGTTVTLTLPLA 108
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
199-426 |
3.12e-28 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 115.89 E-value: 3.12e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 199 LKQLEGMRRNFFANVSHELRTPMTVLQGYLEMTEDpdmlvgpmwgkahGVMTEQLNRMNSLVNQLLTLSKIeASPMHEL- 277
Cdd:PRK10549 233 LEKNEQMRRDFMADISHELRTPLAVLRGELEAIQD-------------GVRKFTPESVASLQAEVGTLTKL-VDDLHQLs 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 278 ----------EDVVDVPAMLEVLEKEAISLSGDDKHQLKFDIDKQLRVLADEDQLRSAISNLVYNAVKYTPPGAEINVRW 347
Cdd:PRK10549 299 lsdegalayrKTPVDLVPLLEVAGGAFRERFASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISA 378
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 348 FQTPQGACLEVEDKGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALSHHDSHLDIK-STVGvGSRFSFVLP 426
Cdd:PRK10549 379 EQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAhSPFG-GVSITVELP 457
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
194-428 |
7.69e-28 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 115.12 E-value: 7.69e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 194 RDVTQLKQLEGMRRNFFANVSHELRTPMTVLQgyleMTED------PDMlvGPMWGKAHGVMTEQLNRMNSLVNQLLTLS 267
Cdd:NF040691 259 RQIRQLEELSRLQQRFVSDVSHELRTPLTTIR----MAADvihdsrDDF--DPATARSAELLHTELDRFESLLSDLLEIS 332
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 268 KIEA-SPMHELEDVVDVPAMLEVLEkEAISLSGDDKHQLKFDIDKQ-LRVLADEDQLRSAISNLVYNAVKYTpPGAEINV 345
Cdd:NF040691 333 RFDAgAAELDVEPVDLRPLVRRVVD-ALRQLAERAGVELRVDAPGTpVVAEVDPRRVERVLRNLVVNAIEHG-EGKPVVV 410
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 346 RWFQTPQGACLEVEDKGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALSHHDSHLDIKSTVGVGSRFSFVL 425
Cdd:NF040691 411 TVAQDDTAVAVTVRDHGVGLKPGEVALVFDRFWRADPARARTTGGTGLGLAIALEDARLHGGWLEAWGRPGQGSQFRLTL 490
|
...
gi 520910886 426 PKR 428
Cdd:NF040691 491 PRV 493
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
215-428 |
4.46e-27 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 112.63 E-value: 4.46e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 215 HELRTPMTVLQGYLE-MTEDPD-----MLVGPMwgkahgvmTEQLNRMNSLVNQLLTLSKIEAspMHELEDV--VDVPAM 286
Cdd:PRK11100 265 HELKSPLAAIRGAAElLQEDPPpedraRFTGNI--------LTQSARLQQLIDRLLELARLEQ--RQELEVLepVALAAL 334
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 287 L-EVLEKEAISLSGddKH-QLKFDIDKqLRVLADEDQLRSAISNLVYNAVKYTPPGAEINVRWFQTPQGACLEVEDKGDG 364
Cdd:PRK11100 335 LeELVEAREAQAAA--KGiTLRLRPDD-ARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPG 411
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 520910886 365 IEPQHLHRLTERFY---RVDKARSrdtgGSGLGLAIVKHALSHHDSHLDIKSTVGVGSRFSFVLPKR 428
Cdd:PRK11100 412 IPDYALPRIFERFYslpRPANGRK----STGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPRH 474
|
|
| PhoR |
pfam11808 |
Phosphate regulon sensor protein PhoR; This family is only found in bacteria. Family members ... |
7-90 |
5.32e-27 |
|
Phosphate regulon sensor protein PhoR; This family is only found in bacteria. Family members include PhoR. A member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR is the bifunctional histidine autokinase/phospho-PhoB phosphatase that donates a phosphoryl group to PhoB when environmental Pi is limiting and removes the phosphoryl group from phosphorylated PhoB (PhoB-P) when environmental Pi is abundant.
Pssm-ID: 432090 Cd Length: 84 Bit Score: 103.07 E-value: 5.32e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 7 WKKLAWELAFFYLPWIVVGWIFGYMPWLLLAATALQLVWHLHNQMRLSAWLWDEKRLTPPSGSGNWEYLFNGIYRLQQRQ 86
Cdd:pfam11808 1 WRRLLWRLALLLLPALLLGLLFGHLAAALLLALLAYLAWHLYQLLRLSRWLWRPRKLTPPDGSGLWGEIFYGLYRLQRRN 80
|
....
gi 520910886 87 RKKR 90
Cdd:pfam11808 81 RRRR 84
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
318-426 |
1.98e-26 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 102.54 E-value: 1.98e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 318 DEDQLRSAISNLVYNAVKYTPPGAEINVRWFQTPQGACLEVEDKGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAI 397
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
90 100 110
....*....|....*....|....*....|
gi 520910886 398 V-KHALSHHDSHLDIKSTVGvGSRFSFVLP 426
Cdd:cd16946 81 ChNIALAHGGTISAEHSPLG-GLRLVLTLP 109
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
79-428 |
2.44e-25 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 106.86 E-value: 2.44e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 79 IYRLQQRQRKKRKELTNLIRRFRNGAESLPDAVVVFRSEGNIVWCNRLAQHLLGFrwpDDAGQPISNLIRtpdfiKYLQK 158
Cdd:COG3290 65 LLLLAALLLKLLEEIARLVEEREAVLESIREGVIAVDRDGRITLINDAARRLLGL---DAIGRPIDEVLA-----EVLET 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 159 DDFTEPLEMRsplnvERSLELRIVPYTEGEHLM----VVRDVTQLK----QLEGMRRnfFANV----SHELRTPMTVLQG 226
Cdd:COG3290 137 GERDEEILLN-----GRVLVVNRVPIRDDGRVVgavaTFRDRTELErleeELEGVKE--LAEAlraqRHDFRNHLHTISG 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 227 YLEMtEDPDmlvgpmwgKAHGVMTEQLNRMNSLVNQLLTLSKieaspmhelEDVVDvpAMLEVLEKEAISLsgddKHQLK 306
Cdd:COG3290 210 LLQL-GEYD--------EALEYIDEISEELQELIDSLLSRIG---------NPVLA--ALLLGKAARARER----GIDLT 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 307 FDIDKQLRVLA-DEDQLRSAISNLVYNAV----KYTPPGAEINVRWFQTPQGACLEVEDKGDGIEPQHLHRLTERFYRvd 381
Cdd:COG3290 266 IDIDSDLPDLPlSDTDLVTILGNLLDNAIeaveKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFS-- 343
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 520910886 382 karSRDTGGSGLGLAIVKHALSHHDSHLDIKSTVGVGSRFSFVLPKR 428
Cdd:COG3290 344 ---TKLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKE 387
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
162-429 |
1.06e-23 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 101.58 E-value: 1.06e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 162 TEPLEMRSPLNVE----RSLELRIVPYTEGEHLMVVRDVTQLKQlegmRRNFFANVSHELRTPMTVLQGYLEMTEdpdml 237
Cdd:PRK10755 93 QKELEARTADNLTpiaiHSSTLEIEAVTSALNQLVSRLTSTLDQ----ERLFTADVAHELRTPLAGIRLHLELLE----- 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 238 vgpmwgKAHGV----MTEQLNRMNSLVNQLLTLSKIE---ASPMHE----LEDVVdVPAMLEVLEkeaisLSGDDKHQLK 306
Cdd:PRK10755 164 ------KQHHIdvapLIARLDQMMHTVEQLLQLARAGqsfSSGHYQtvklLEDVI-LPSQDELSE-----MLEQRQQTLL 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 307 F-DIDKQLRVLADEDQLRSAISNLVYNAVKYTPPGAEINVRWFQTPQGACLEVEDKGDGIEPQHLHRLTERFYRVDkarS 385
Cdd:PRK10755 232 LpESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRMD---S 308
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 520910886 386 RdTGGSGLGLAIVKHALSHHDSHLDIKSTV-GVGSRFSFVLPKRL 429
Cdd:PRK10755 309 R-YGGIGLGLSIVSRITQLHHGQFFLQNRQeRSGTRAWVWLPKAQ 352
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
322-426 |
1.15e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 94.87 E-value: 1.15e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 322 LRSAISNLVYNAVKYTPPGA-EINVRWFQTPQGA---CLEVEDKGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAI 397
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEGEvTLRVSLEEEEEDGvqlRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 520910886 398 VKHALSHHDSHLDIKSTVGVGSRFSFVLP 426
Cdd:cd16922 81 SKKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
209-426 |
2.24e-23 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 103.32 E-value: 2.24e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 209 FFANVSHELRTPMTVLQGYLEMTEDPdmlvgpmwgkahGVMTEQ---LNRMN-------SLVNQLLTLSKIEASPMHELE 278
Cdd:TIGR02956 467 FLATMSHEIRTPLNGILGTLELLGDT------------GLTSQQqqyLQVINrsgesllDILNDILDYSKIEAGHLSISP 534
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 279 DVVDVPAMLEvlEKEAISLSG-DDKH-QLKFDIDKQLR--VLADEDQLRSAISNLVYNAVKYTPPGaEINVRWFQTPQGA 354
Cdd:TIGR02956 535 RPFDLNALLD--DVHHLMVSRaQLKGiQLRLNIPEQLPnwWQGDGPRIRQVLINLVGNAIKFTDRG-SVVLRVSLNDDSS 611
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 520910886 355 CL-EVEDKGDGIEPQHLHRLTERFYRVDKARSrdTGGSGLGLAIVKHALSHHDSHLDIKSTVGVGSRFSFVLP 426
Cdd:TIGR02956 612 LLfEVEDTGCGIAEEEQATLFDAFTQADGRRR--SGGTGLGLAISQRLVEAMDGELGVESELGVGSCFWFTLP 682
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
212-429 |
1.47e-22 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 99.29 E-value: 1.47e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 212 NVSHELRTPMTVLQGYLEMTEDPDMlvgpmwgkahgvmTEQ--LNR----MNSLVNQLLTLSKIEaSPMHELE-DVVDVP 284
Cdd:PRK10604 218 GIAHELRTPLVRLRYRLEMSDNLSA-------------AESqaLNRdigqLEALIEELLTYARLD-RPQNELHlSEPDLP 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 285 AMLEvlEKEAISLSGDDKHQLKFDI-DKQLRVLADEDQLRSAISNLVYNAVKYtppgAEINVR---WFQTPQgACLEVED 360
Cdd:PRK10604 284 AWLS--THLADIQAVTPEKTVRLDTpHQGDYGALDMRLMERVLDNLLNNALRY----AHSRVRvslLLDGNQ-ACLIVED 356
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 520910886 361 KGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALSHHDSHLDIKSTVGVGSRFSFVLPKRL 429
Cdd:PRK10604 357 DGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWPVWH 425
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
148-410 |
3.23e-22 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 98.18 E-value: 3.23e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 148 RTPDFIKYLQKDDFtePLEMRSPLNVERSLELRIvpytegeHLMVVRDvtqlkqlegmrRNFFANVSHELRTPMTVLQGY 227
Cdd:PRK10337 199 RDPDSETPLNATGV--PSEVRPLVEALNQLFART-------HAMMVRE-----------RRFTSDAAHELRSPLAALKVQ 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 228 LEMTE----DPDMLvgpmwGKAHGVMTEQLNRMNSLVNQLLTLSKIEAspMHELEDVVDVPaMLEVLEKEAISLsgdDKH 303
Cdd:PRK10337 259 TEVAQlsddDPQAR-----KKALLQLHAGIDRATRLVDQLLTLSRLDS--LDNLQDVAEIP-LEDLLQSAVMDI---YHT 327
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 304 QLKFDIDKQLRvLADEDQLRSA--------ISNLVYNAVKYTPPGAEINVRWfqTPQgaCLEVEDKGDGIEPQHLHRLTE 375
Cdd:PRK10337 328 AQQAGIDVRLT-LNAHPVIRTGqplllsllVRNLLDNAIRYSPQGSVVDVTL--NAR--NFTVRDNGPGVTPEALARIGE 402
|
250 260 270
....*....|....*....|....*....|....*
gi 520910886 376 RFYRvdkARSRDTGGSGLGLAIVKHALSHHDSHLD 410
Cdd:PRK10337 403 RFYR---PPGQEATGSGLGLSIVRRIAKLHGMNVS 434
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
211-426 |
8.44e-22 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 96.86 E-value: 8.44e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 211 ANVSHELRTPMTVLQGYLEMTEDPDmlvgPMWGKA---HGVMTEQLNRMNSLVNQLLTLSK-----IEASPM-HELEDVV 281
Cdd:COG5806 206 ASIAHEVRNPLTVVRGFIQLLQEPE----LSDEKRkqyIRIALEELDRAEAIITDYLTFAKpqpekLEKIDVsEELEHVI 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 282 DVPAMLEVLEKEAISLsgddkhqlkfDIDKQLRVLADEDQLRSAISNLVYNAVKYTPPGAEINVRWFQTPQGACLEVEDK 361
Cdd:COG5806 282 DVLSPYANMNNVEIQT----------ELEPGLYIEGDRQKLQQCLINIIKNGIEAMPNGGTLTIDVSIDKNKVIISIKDT 351
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 520910886 362 GDGIEPQHLHRLTERFYrvdkarSRDTGGSGLGLAIVKHALSHHDSHLDIKSTVGVGSRFSFVLP 426
Cdd:COG5806 352 GVGMTKEQLERLGEPYF------STKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITLP 410
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
193-411 |
9.53e-22 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 96.90 E-value: 9.53e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 193 VRDVTQ--------LKQLEGMRRNFFANVSHELRTPMTVLQGYLEM-TEDPDMLvgpmwgkAHGvMTEQLNRMNSLVNQL 263
Cdd:PRK09467 208 VRSVTRafnqmaagIKQLEDDRTLLMAGVSHDLRTPLTRIRLATEMmSEEDGYL-------AES-INKDIEECNAIIEQF 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 264 LTLSKIEASPMHELEDVVDvpamlevLEKEAISLSGDDKHQLKFDI-DKQLRVLADEDQLRSAISNLVYNAVKYTppGAE 342
Cdd:PRK09467 280 IDYLRTGQEMPMEMADLNA-------LLGEVIAAESGYEREIETALqPGPIEVPMNPIAIKRALANLVVNAARYG--NGW 350
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 520910886 343 INVRWFQTPQGACLEVEDKGDGIEPQHLHRLTERFYRVDKARSrdTGGSGLGLAIVKHALSHHDSHLDI 411
Cdd:PRK09467 351 IKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARG--SSGTGLGLAIVKRIVDQHNGKVEL 417
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
211-426 |
2.01e-21 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 97.02 E-value: 2.01e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 211 ANVSHELRTPMTVLQGYLEMTEDpdmlvGPMWGKAHGVMTEQLNRMNSL---VNQLLTLSKIEASPMH-ELEDVVDVP-- 284
Cdd:PRK15347 403 TTISHEIRTPLNGVLGALELLQN-----TPLTAEQMDLADTARQCTLSLlaiINNLLDFSRIESGQMTlSLEETALLPll 477
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 285 --AML----EVLEKeAISLS---GDDKhQLKFDIDKqLRvladedqLRSAISNLVYNAVKYTPPGaEINVRWFQTPQGAC 355
Cdd:PRK15347 478 dqAMLtiqgPAQSK-SLTLRtfvGAHV-PLYLHLDS-LR-------LRQILVNLLGNAVKFTETG-GIRLRVKRHEQQLC 546
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 520910886 356 LEVEDKGDGIEPQHLHRLTERFYRVDKarsrDTGGSGLGLAIVKHALSHHDSHLDIKSTVGVGSRFSFVLP 426
Cdd:PRK15347 547 FTVEDTGCGIDIQQQQQIFTPFYQADT----HSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLP 613
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
211-427 |
2.20e-21 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 94.68 E-value: 2.20e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 211 ANVSHELRTPMTVLQGYLEmtedpdmlvgpmwGKAHGVMTEQLNRMNSLVNQ----------LLTLSKIEAspmHELEDV 280
Cdd:NF012226 143 AAIAHELRTPITILQGRLQ-------------GILDGVFEPDPALFKSLLNQveglshlvedLRTLSLVEN---QQLRLN 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 281 VDVPAMLEVLEKeAISLSGDDKHQLKFDIDKQLR---VLADEDQLRSAISNLVYNAVKYTPPGaEINVRWFQTPQGACLE 357
Cdd:NF012226 207 YESVDLKDSIEK-VLKMFEDRLEQAQLTIVLNLTatpVFCDRRRIEQVLIALIDNAIRYANAG-KLKISSSVIQDDWILQ 284
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 358 VEDKGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALSHHDSHLDIkSTVGVGSRFSFVLPK 427
Cdd:NF012226 285 IEDEGPGIAEEYQQDLFNPFFRLEQSRNKEFGGTGLGLAVVHAIVIAHKGSIEY-SNSQGNSVFTIKLPA 353
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
178-426 |
7.71e-21 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 95.39 E-value: 7.71e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 178 ELRIVPY--TEGEHLMVV---RDVTQLKQ----LEGMRRN---FFANVSHELRTPMTVLQGYLEMTEDPDMlvgpmwgka 245
Cdd:PRK11091 243 ELRKVPFydRVGKRHGLMgfgRDITERKRyqdaLEKASRDkttFISTISHELRTPLNGIVGLSRILLDTEL--------- 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 246 hgvMTEQLNRMNS----------LVNQLLTLSKIEASPMHELEDVVDVPAMLEVLEkeaiSLSG---DDKhQLKFDIDKQ 312
Cdd:PRK11091 314 ---TAEQRKYLKTihvsaitlgnIFNDIIDMDKMERRKLQLDNQPIDFTDFLADLE----NLSGlqaEQK-GLRFDLEPL 385
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 313 L----RVLADEDQLRSAISNLVYNAVKYTPPGaEINVR-WFQTPQGACLEVEDKGDGIEPQHLHRLTERFYRV-DKARSR 386
Cdd:PRK11091 386 LplphKVITDGTRLRQILWNLISNAVKFTQQG-GVTVRvRYEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVkDSHGGK 464
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 520910886 387 DTGGSGLGLAIVKHALSHHDSHLDIKSTVGVGSRFSFVLP 426
Cdd:PRK11091 465 PATGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIH 504
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
315-420 |
8.40e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 87.08 E-value: 8.40e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 315 VLADEDQLRSAISNLVYNAVKYTPPGAEINVRwFQTPQGACLEVEDKGDGIEPQHLHRLTERFYRVDKarsRDTGGSGLG 394
Cdd:cd16940 7 VQGDALLLFLLLRNLVDNAVRYSPQGSRVEIK-LSADDGAVIRVEDNGPGIDEEELEALFERFYRSDG---QNYGGSGLG 82
|
90 100
....*....|....*....|....*.
gi 520910886 395 LAIVKHALSHHDSHLDIKSTVGVGSR 420
Cdd:cd16940 83 LSIVKRIVELHGGQIFLGNAQGGGLE 108
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-427 |
6.07e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 84.30 E-value: 6.07e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 322 LRSAISNLVYNAVKYTPpgAEINVRWFQTPQGACLEVEDKGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHA 401
Cdd:cd16949 1 LARALENVLRNALRYSP--SKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERA 78
|
90 100
....*....|....*....|....*.
gi 520910886 402 LSHHDSHLDIKSTVGVGSRFSFVLPK 427
Cdd:cd16949 79 IEQHGGKIKASNRKPGGLRVRIWLPA 104
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-426 |
1.20e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 83.53 E-value: 1.20e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 322 LRSAISNLVYNAVKYTPPG--AEINVRWFQTPQGACLEVEDKGDGIEPQHLHRLTERFYRVDkarSRDT-GGSGLGLAIV 398
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRrpPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLH---SREEyEGTGVGLAIV 77
|
90 100
....*....|....*....|....*...
gi 520910886 399 KHALSHHDSHLDIKSTVGVGSRFSFVLP 426
Cdd:cd16921 78 RKIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
203-426 |
1.60e-18 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 88.17 E-value: 1.60e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 203 EGMRRNFFANVSHELRTPMTVLQGYLEMTedpdMLVGPMWGKAHgvmTEQLNRMNS-------LVNQLLTLSKIEASPMH 275
Cdd:PRK10490 661 EQLRNALLAALSHDLRTPLTVLFGQAEIL----TLDLASEGSPH---ARQASEIRQqvlnttrLVNNLLDMARIQSGGFN 733
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 276 ------ELEDVVDvpAMLEVLEkeaISLSGddkHQLKFDIDKQLRVL-ADEDQLRSAISNLVYNAVKYTPPGAEINVRWF 348
Cdd:PRK10490 734 lrkewlTLEEVVG--SALQMLE---PGLSG---HPINLSLPEPLTLIhVDGPLFERVLINLLENAVKYAGAQAEIGIDAH 805
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 520910886 349 QTPQGACLEVEDKGDGIEPQHLHRLTERFYRVDKARSrdTGGSGLGLAIVKHALSHHDSHLDIKSTVGVGSRFSFVLP 426
Cdd:PRK10490 806 VEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESA--IPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLP 881
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-418 |
3.02e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 79.42 E-value: 3.02e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 322 LRSAISNLVYNAVKYTppGAEINVRWFQTPQGACLEVEDKGDGIEPQHLHRLTERFYRVDKArsRDTGGSGLGLAIVKHA 401
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNA--RGTSGTGLGLAIVQRI 76
|
90
....*....|....*..
gi 520910886 402 LSHHDSHLDIKSTVGVG 418
Cdd:cd16950 77 SDAHGGSLTLANRAGGG 93
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
213-405 |
5.02e-18 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 85.75 E-value: 5.02e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 213 VSHELRTPMTVLQgylemtedpdMLVGPMWGKaHGVMTE------QLNRMNSLVNQLLTLSKI--------EASPMHEL- 277
Cdd:PRK09470 250 ISHELRTPLTRLQ----------LATALLRRR-QGESKElerietEAQRLDSMINDLLVLSRNqqknhlerETFKANSLw 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 278 EDVvdvpamLEVLEKEAislsgdDKHQLKFDIDKQLR---VLADEDQLRSAISNLVYNAVKYTppGAEINVRWFQTPQGA 354
Cdd:PRK09470 319 SEV------LEDAKFEA------EQMGKSLTVSAPPGpwpINGNPNALASALENIVRNALRYS--HTKIEVAFSVDKDGL 384
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 520910886 355 CLEVEDKGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALSHH 405
Cdd:PRK09470 385 TITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQH 435
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
75-430 |
1.19e-17 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 85.56 E-value: 1.19e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 75 LFNGIYRLQQRQRKK--RKELTNLIRRFRNGAESLPDAVVVFRSEGNIVWCNRLAQHLLGFRWPDDAGQPISNlIRTPdf 152
Cdd:PRK09959 551 LLWGFYLLRSVRRRKviQGDLENQISFRKALSDSLPNPTYVVNWQGNVISHNSAFEHYFTADYYKNAMLPLEN-SDSP-- 627
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 153 ikylQKDDFTEPLEMRSPLNVERSLELRIVPYTEG------------------EHLMVV---RDVTQLKQL---EGMRRN 208
Cdd:PRK09959 628 ----FKDVFSNAHEVTAETKENRTIYTQVFEIDNGiekrcinhwhtlcnlpasDHAVYIcgwQDITETRDLihaLEVERN 703
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 209 -----------FFANVSHELRTPMTVLQGYLEMtedpdmLVGPMWGKAHGVMTEQL-----NRMNSLVNQLLTLSKIEAS 272
Cdd:PRK09959 704 kainatvaksqFLATMSHEIRTPISSIMGFLEL------LSGSGLSKEQRVEAISLayatgQSLLGLIGEILDVDKIESG 777
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 273 PMHELEDVVDVPAMLE--------VLEKEAISLSGDDKhqlkfdIDKQLRVLADEDQLRSAISNLVYNAVKYTPPGA-EI 343
Cdd:PRK09959 778 NYQLQPQWVDIPTLVQntchsfgaIAASKSIALSCSST------FPDHYLVKIDPQAFKQVLSNLLSNALKFTTEGAvKI 851
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 344 NVRWFQTPQGAC---LEVEDKGDGIEPQHLHRLTERFYRVDKARSRDtgGSGLGLAIVKHALSHHDSHLDIKSTVGVGSR 420
Cdd:PRK09959 852 TTSLGHIDDNHAvikMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQT--GSGLGLMICKELIKNMQGDLSLESHPGIGTT 929
|
410
....*....|
gi 520910886 421 FSFVLPKRLV 430
Cdd:PRK09959 930 FTITIPVEIS 939
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
205-271 |
2.82e-17 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 75.71 E-value: 2.82e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 520910886 205 MRRNFFANVSHELRTPMTVLQGYLEMTEDPDmlVGPMWGKAHGVMTEQLNRMNSLVNQLLTLSKIEA 271
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEK--LDEEQREYLETILRSAERLLRLINDLLDLSRIEA 65
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
318-426 |
1.69e-16 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 74.84 E-value: 1.69e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 318 DEDQLRSAISNLVYNAVKYTPPGAEINVRWFQT-PQGACLEVEDKGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLA 396
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFrLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80
|
90 100 110
....*....|....*....|....*....|
gi 520910886 397 IVKHALSHHDSHLDIKSTVGVGSRFSFVLP 426
Cdd:cd16925 81 IVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
318-426 |
2.73e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 74.24 E-value: 2.73e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 318 DEDQLRSAISNLVYNAVKYTPPGAEINVRWFQTPQGACLEVEDKGDGIEPQHLHRLTERFYRVDKARsRDTGGSGLGLAI 397
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGR-NFQESTGMGLYL 80
|
90 100
....*....|....*....|....*....
gi 520910886 398 VKHALSHHDSHLDIKSTVGVGSRFSFVLP 426
Cdd:cd16948 81 VKKLCDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
205-271 |
3.18e-16 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 72.60 E-value: 3.18e-16
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 520910886 205 MRRNFFANVSHELRTPMTVLQGYLEMTEDPDMLVGPmwGKAHGVMTEQLNRMNSLVNQLLTLSKIEA 271
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQ--REYLETILREAERLLRLINDLLDLSRIEA 65
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-426 |
7.29e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 72.80 E-value: 7.29e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 322 LRSAISNLVYNAVKYTPPGAEINVRWFQTPQGACLEVEDKGDGIEPQHLHRLTERFYRVDKarSRDTGGSGLGLAIVKHA 401
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDN--SRNTEGAGLGLSIAKAI 78
|
90 100
....*....|....*....|....*
gi 520910886 402 LSHHDSHLDIKSTvGVGSRFSFVLP 426
Cdd:cd16923 79 IELHGGSASAEYD-DNHDLFKVRLP 102
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
211-426 |
8.36e-16 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 79.06 E-value: 8.36e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 211 ANVSHELRTPMTVLQGYLEMTEDPdmlvGPMWGKAHG---VMTEQLNRMNSLVNQLLTLSKieasPMHELEDVVDVPAML 287
Cdd:PRK10364 242 AGVAHEIRNPLSSIKGLAKYFAER----APAGGEAHQlaqVMAKEADRLNRVVSELLELVK----PTHLALQAVDLNDLI 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 288 EvlekEAISL-SGDDKH---QLKFDIDKQL-RVLADEDQLRSAISNLVYNAVKYTPPGAEINVRWFQTPQGACLEVEDKG 362
Cdd:PRK10364 314 N----HSLQLvSQDANSreiQLRFTANDTLpEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSG 389
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 520910886 363 DGIEPQHLHRLTERFYrVDKARsrdtgGSGLGLAIVKHALSHHDSHLDIKSTVGVGSRFSFVLP 426
Cdd:PRK10364 390 KGIAADQLEAIFTPYF-TTKAE-----GTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLP 447
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
325-426 |
5.73e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 70.54 E-value: 5.73e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 325 AISNLVYNAVKYtppgAEINVRWFQTPQG--ACLEVEDKGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHAL 402
Cdd:cd16939 4 ALDNLLRNALRY----AHRTVRIALLVSGgrLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVA 79
|
90 100
....*....|....*....|....
gi 520910886 403 SHHDSHLDIKSTVGVGSRFSFVLP 426
Cdd:cd16939 80 LWHGGHVECDDSELGGACFRLTWP 103
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
213-428 |
1.22e-14 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 76.25 E-value: 1.22e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 213 VSHELRTPMTVLQGYLEMTEDpdMLvgpmwgKAHGVMTEQL-------NRMNSLVNQLLTLSKIEASPMH--ELEDVVDV 283
Cdd:PRK13837 457 IAHNFNNILGAILGYAEMALN--KL------ARHSRAARYIdeiisagARARLIIDQILAFGRKGERNTKpfDLSELVTE 528
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 284 PA-MLEVLEKEAISLSgddkhqLKFDiDKQLRVLADEDQLRSAISNLVYNAVKYTPPGAEINVRWFQ------------- 349
Cdd:PRK13837 529 IApLLRVSLPPGVELD------FDQD-QEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISLSRaklrapkvlshgv 601
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 350 TPQG--ACLEVEDKGDGIEPQHLHRLTERFYrvdKARSrdtGGSGLGLAIVKHALSHHDSHLDIKSTVGVGSRFSFVLPK 427
Cdd:PRK13837 602 LPPGryVLLRVSDTGAGIDEAVLPHIFEPFF---TTRA---GGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLPP 675
|
.
gi 520910886 428 R 428
Cdd:PRK13837 676 S 676
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
211-426 |
1.71e-14 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 74.60 E-value: 1.71e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 211 ANVSHELRTPMTVLQGYLEMTE-----DPDMLVGPMWGKAHGVMTEQLNRMNSLVNQLLTLSKI--EASPMHELEdvVDV 283
Cdd:PRK09303 156 AMLAHDLRTPLTAASLALETLElgqidEDTELKPALIEQLQDQARRQLEEIERLITDLLEVGRTrwEALRFNPQK--LDL 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 284 PAM-LEVLEkEAISLSGDDKHQLKFDIDKQL-RVLADEDQLRSAISNLVYNAVKYTPPGAEINVRWF-QTPQGACLEVED 360
Cdd:PRK09303 234 GSLcQEVIL-ELEKRWLAKSLEIQTDIPSDLpSVYADQERIRQVLLNLLDNAIKYTPEGGTITLSMLhRTTQKVQVSICD 312
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 520910886 361 KGDGIEPQHLHRLTERFYRVDkaRSRDTGGSGLGLAIVKHALSHHDSHLDIKSTVGVGSRFSFVLP 426
Cdd:PRK09303 313 TGPGIPEEEQERIFEDRVRLP--RDEGTEGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTLP 376
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
205-268 |
1.82e-14 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 67.62 E-value: 1.82e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 520910886 205 MRRNFFANVSHELRTPMTVLQGYLEMTEDpDMLVGPMWGKAHGVMTEQLNRMNSLVNQLLTLSK 268
Cdd:cd00082 3 AKGEFLANVSHELRTPLTAIRGALELLEE-ELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-412 |
3.21e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 68.26 E-value: 3.21e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 322 LRSAISNLVYNAVKYTPPGAEINVRWFQTPQGACLEVEDKGDGIEPQHLHRLTERFYRVDKARSRDTgGSGLGLAIVKHA 401
Cdd:cd16945 5 LRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQK-STGLGLAFVQEV 83
|
90
....*....|.
gi 520910886 402 LSHHDSHLDIK 412
Cdd:cd16945 84 AQLHGGRITLR 94
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
209-428 |
2.19e-13 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 72.25 E-value: 2.19e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 209 FFANVSHELRTPMTVLQGYLEMTEDPDMLvgPMWGKAHGVMTEQLNRMNSLVNQLLTLSKIEA------------SPMHE 276
Cdd:PRK11466 447 FLAAMSHEIRTPLYGILGTAQLLADNPAL--NAQRDDLRAITDSGESLLTILNDILDYSAIEAggknvsvsdepfEPRPL 524
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 277 LEDVVDVpaMLEVLEKEAISLSGDDKHQLKfdidkqLRVLADEDQLRSAISNLVYNAVKYTPPGAeINVRWFQTPQGACL 356
Cdd:PRK11466 525 LESTLQL--MSGRVKGRPIRLATDIADDLP------TALMGDPRRIRQVITNLLSNALRFTDEGS-IVLRSRTDGEQWLV 595
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 520910886 357 EVEDKGDGIEPQHLHRLTERFYRVDKARsrdtGGSGLGLAIVKHALSHHDSHLDIKSTVGVGSRFSFVLPKR 428
Cdd:PRK11466 596 EVEDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPLR 663
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
209-426 |
2.84e-13 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 71.93 E-value: 2.84e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 209 FFANVSHELRTPMTVLQGYLEM------TEDPDMLVGPMwgkahgvmteqlNRMNSL----VNQLLTLSKIEASPMHele 278
Cdd:PRK10841 450 FLATVSHELRTPLYGIIGNLDLlqtkelPKGVDRLVTAM------------NNSSSLllkiISDILDFSKIESEQLK--- 514
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 279 dvvdvpamLEVLE---KEAIS------LSGDDKHQLKF----DIDKQLRVLADEDQLRSAISNLVYNAVKYTPPGAEInv 345
Cdd:PRK10841 515 --------IEPREfspREVINhitanyLPLVVKKRLGLycfiEPDVPVALNGDPMRLQQVISNLLSNAIKFTDTGCIV-- 584
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 346 rwFQ-TPQGACLE--VEDKGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALSHHDSHLDIKSTVGVGSRFS 422
Cdd:PRK10841 585 --LHvRVDGDYLSfrVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMDGDISVDSEPGMGSQFT 662
|
....
gi 520910886 423 FVLP 426
Cdd:PRK10841 663 IRIP 666
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
105-428 |
4.20e-13 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 70.11 E-value: 4.20e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 105 ESLPDAVVVFRSEGNIVWCNRLAQHLLGFRWPDDAGQPIsnlirtPDFIKYLQKDdftepLE-MRSPL------------ 171
Cdd:PRK11073 14 NSLINSILLLDDDLAIHYANPAAQQLLAQSSRKLFGTPL------PELLSYFSLN-----IElMRESLqagqgftdnevt 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 172 ----NVERSLELRIVPYTEGEHLMVVRDVTQLKQL---------EGMRRNFFANVSHELRTPMTVLQGYLEMTEDpdMLV 238
Cdd:PRK11073 83 lvidGRSHILSLTAQRLPEGMILLEMAPMDNQRRLsqeqlqhaqQVAARDLVRGLAHEIKNPLGGLRGAAQLLSK--ALP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 239 GPMWGKAHGVMTEQLNRMNSLVNQLLTLSKieasP-MHELEDVvdvpamLEVLEK--EAISLSGDDKHQLKFDIDKQLRV 315
Cdd:PRK11073 161 DPALTEYTKVIIEQADRLRNLVDRLLGPQR----PgTHVTESI------HKVAERvvQLVSLELPDNVRLIRDYDPSLPE 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 316 LA-DEDQLRSAISNLVYNAVK-YTPPGAEINVRW---FQ-TPQG------ACLEVEDKGDGIEPQHLHRLterFYRVDKA 383
Cdd:PRK11073 231 LAhDPDQIEQVLLNIVRNALQaLGPEGGTITLRTrtaFQlTLHGeryrlaARIDIEDNGPGIPPHLQDTL---FYPMVSG 307
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 520910886 384 RSrdtGGSGLGLAIVKHALSHHDSHLDIKSTVGvGSRFSFVLPKR 428
Cdd:PRK11073 308 RE---GGTGLGLSIARNLIDQHSGKIEFTSWPG-HTEFSVYLPIR 348
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
321-426 |
4.66e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 65.14 E-value: 4.66e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 321 QLRSAISNLVYNAVKYTPPGAEINVRWFQTPQGACLEVEDKGDGIEPQHLHRLTERFYRVDKARSrdtgGSGLGLAIVKH 400
Cdd:cd16943 3 QLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGE----GTGLGLSLSYR 78
|
90 100
....*....|....*....|....*.
gi 520910886 401 ALSHHDSHLDIKSTVGVGSRFSFVLP 426
Cdd:cd16943 79 IIQKHGGTIRVASVPGGGTRFTIILP 104
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
304-399 |
1.44e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 64.46 E-value: 1.44e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 304 QLKFDI-DKQLRVLADEDQLRSAISNLVYNAVKYTPPGAEINVRWFQTPQGACLEVEDKGDGIEPQHLHRLTERFYRVDK 382
Cdd:cd16947 2 QVEINIpDRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLED 81
|
90
....*....|....*..
gi 520910886 383 ARSRDTGGSGLGLAIVK 399
Cdd:cd16947 82 SRNSAKQGNGLGLTITK 98
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
301-425 |
5.62e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 63.03 E-value: 5.62e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 301 DKH-QLKFDIDKQLRVLADEDQLRSAISNLVYNAVKYTPPGAEINVRwfQTPQGACLEVEDKGDGIEPQHLHRLTERFYR 379
Cdd:cd16954 16 RKGvSISLDISPELRFPGERNDLMELLGNLLDNACKWCLEFVEVTAR--QTDGGLHLIVDDDGPGVPESQRSKIFQRGQR 93
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 520910886 380 VDKARSrdtgGSGLGLAIVKHALSHHDSHLDIKSTVGVGSRFSFVL 425
Cdd:cd16954 94 LDEQRP----GQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
209-429 |
1.42e-11 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 66.41 E-value: 1.42e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 209 FFANVSHELRTPmtvLQGYLEMTEDpdMLVGPMwgkaHGVMTEQLNRM----NSL---VNQLLTLSKIEASPMhELEDVv 281
Cdd:PRK11107 296 FLANMSHELRTP---LNGVIGFTRQ--TLKTPL----TPTQRDYLQTIersaNNLlaiINDILDFSKLEAGKL-VLENI- 364
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 282 dvPAML-EVLEkEAISL---SGDDKH-QLKFDIDKQL--RVLADEDQLRSAISNLVYNAVKYTPPGAeINVRW---FQTP 351
Cdd:PRK11107 365 --PFSLrETLD-EVVTLlahSAHEKGlELTLNIDPDVpdNVIGDPLRLQQIITNLVGNAIKFTESGN-IDILVelrALSN 440
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 352 QGACLEVE--DKGDGIEPQHLHRLTERFYRVDKARSRDTGGSGLGLAIVKHALSHHDSHLDIKSTVGVGSRFSFVLPKRL 429
Cdd:PRK11107 441 TKVQLEVQirDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQKLVNEMGGDISFHSQPNRGSTFWFHLPLDL 520
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
318-423 |
4.65e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 59.40 E-value: 4.65e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 318 DEDQLRSAISNLVYNAVKYTPPGAEINVRWFQTPQGACLEVEDKGDGIEPQHLHRLTERFYRVDKARsRDTGGSGLGLAI 397
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSR-RSGGHYGMGLYI 79
|
90 100
....*....|....*....|....*.
gi 520910886 398 VKHALSHHDSHLDIKSTVGVGSRFSF 423
Cdd:cd16975 80 AKNLVEKHGGSLIIENSQKGGAEVTV 105
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-426 |
6.10e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 56.43 E-value: 6.10e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 322 LRSAISNLVYNAVKYTPPG-AEINVRWFQTPQGACLEVEDKGDGIEPQHLHRLTERFYrVDKARSRDTG-GSGLGLAIVK 399
Cdd:cd16953 1 LGQVLRNLIGNAISFSPPDtGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFY-TERPANEAFGqHSGLGLSISR 79
|
90 100 110
....*....|....*....|....*....|.
gi 520910886 400 HALSHHD--SHLDIKSTVGV--GSRFSFVLP 426
Cdd:cd16953 80 QIIEAHGgiSVAENHNQPGQviGARFTVQLP 110
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
196-426 |
3.25e-09 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 58.99 E-value: 3.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 196 VTQLKQLEGMRRNFFANVSHELRTPMTVLQGYLE---MTEDPDMLVGPMwGKAHgvmtEQLNRMNSLVNQLLTLSKIEAS 272
Cdd:TIGR03785 475 VARLRQYTHYLENMSSRLSHELRTPVAVVRSSLEnleLQALEQEKQKYL-ERAR----EGTERLSMILNNMSEATRLEQA 549
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 273 pmheledvvdvpamLEVLEKEAISLSG------------DDKHQLKFDIDKQLRVL-ADEDQLRSAISNLVYNAVKYTPP 339
Cdd:TIGR03785 550 --------------IQSAEVEDFDLSEvlsgcmqgyqmtYPPQRFELNIPETPLVMrGSPELIAQMLDKLVDNAREFSPE 615
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 340 GAEINVRWFQTPQGACLEVEDKGDGIePQHLH-RLTERFYRVDKARSRDTGGSGLGLAIVKHALSHHDSHLDIKSTV-GV 417
Cdd:TIGR03785 616 DGLIEVGLSQNKSHALLTVSNEGPPL-PEDMGeQLFDSMVSVRDQGAQDQPHLGLGLYIVRLIADFHQGRIQAENRQqND 694
|
....*....
gi 520910886 418 GSRFSFVLP 426
Cdd:TIGR03785 695 GVVFRISLP 703
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
98-196 |
1.12e-08 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 52.80 E-value: 1.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 98 RRFRNGAESLPDAVVVFRSEGNIVWCNRLAQHLLGFRWPDDAGQPISNLIRTPDFIKylQKDDFTEPLE-MRSPLNVERS 176
Cdd:pfam00989 1 EDLRAILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIPEEDDAE--VAELLRQALLqGEESRGFEVS 78
|
90 100 110
....*....|....*....|....*....|....*
gi 520910886 177 ----------LELRIVPYTEGEH-----LMVVRDV 196
Cdd:pfam00989 79 frvpdgrprhVEVRASPVRDAGGeilgfLGVLRDI 113
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
86-203 |
1.33e-08 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 55.42 E-value: 1.33e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 86 QRKKRKELTNLIRRFRNGAESLPDAVVVFRSEGNIVWCNRLAQHLLGFRWPDDAGQPISNLIRTPDFIKYLQ-------- 157
Cdd:COG2202 125 RKRAEEALRESEERLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKSLLDLLHPEDRERLLEllrrlleg 204
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 520910886 158 -KDDFTEPLEMRSPLNVERSLELRIVPYTEGEH----LMVVRDVTQLKQLE 203
Cdd:COG2202 205 gRESYELELRLKDGDGRWVWVEASAVPLRDGGEvigvLGIVRDITERKRAE 255
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
183-398 |
1.98e-08 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 56.18 E-value: 1.98e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 183 PYTEGEHLMVVRDVTQLKQLEGMR----RNFFANVSHELRTPMTVLQGYL-EMTEDPDMLVgpmwGKAHGVMTEQLNRMN 257
Cdd:PRK10815 239 PNPPRELTSLVRNLNRLLKNERERytkyRTTLTDLTHSLKTPLAVLQSTLrSLRSGKQMSV----EQAEPIMLEQISRIS 314
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 258 SLVNQLLTLSKIEASPMHELEDVVDVPAMLE--------VLEKEAISLSgddkhqlkFDIDKQLRVLADEDQLRSAISNL 329
Cdd:PRK10815 315 QQIGYYLHRASMRSEHNLLSRELHSVAPLLDnltsalnkVYQRKGVNIT--------LDISPEITFVGEKNDFMEVMGNV 386
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 520910886 330 VYNAVKYTPPGAEINVRwfQTPQGACLEVEDKGDGIEPQHLHRLTERFYRVDKARSrdtgGSGLGLAIV 398
Cdd:PRK10815 387 LDNACKYCLEFVEISAR--QTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRP----GQGLGLSVA 449
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
318-426 |
2.94e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 51.38 E-value: 2.94e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 318 DEDQLRSAISNLVYNA------VKYTPPGAEINVRWFQTPQGAcLEVEDKGDGIEPQHLHRLTERfYRVDKARsrdtgGS 391
Cdd:cd16944 1 DTTQISQVLTNILKNAaeaiegRPSDVGEVRIRVEADQDGRIV-LIVCDNGKGFPREMRHRATEP-YVTTRPK-----GT 73
|
90 100 110
....*....|....*....|....*....|....*
gi 520910886 392 GLGLAIVKHALSHHDSHLDIKSTVGVGSRFSFVLP 426
Cdd:cd16944 74 GLGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
88-203 |
8.00e-08 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 53.10 E-value: 8.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 88 KKRKELTNLIRRFRNGAESLPDAVVVFRSEGNIVWCNRLAQHLLGFRWPDDAGQPISNLIRTPDFIKYLQKDD------- 160
Cdd:COG2202 1 TAEEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLPPEDDDEFLELLRaalaggg 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 520910886 161 -FTEPLEMRSPLNVERSLELRIVPYT--EGE---HLMVVRDVTQLKQLE 203
Cdd:COG2202 81 vWRGELRNRRKDGSLFWVELSISPVRdeDGEitgFVGIARDITERKRAE 129
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
322-426 |
1.02e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 50.07 E-value: 1.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 322 LRSAISNLVYNAVKYTPPGAEINVRWFQTPQGA---------------CLEVEDKGDGIEPQHLHRLTERFYrvdkaRSR 386
Cdd:cd16919 1 LELAILNLAVNARDAMPEGGRLTIETSNQRVDAdyalnyrdlipgnyvCLEVSDTGSGMPAEVLRRAFEPFF-----TTK 75
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 520910886 387 DTG-GSGLGLAIVKHALSHHDSHLDIKSTVGVGSRFSFVLP 426
Cdd:cd16919 76 EVGkGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
329-428 |
1.75e-07 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 53.10 E-value: 1.75e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 329 LVYNAVKY----TPPGAEINVRWFQTPQGACLEVEDKGDGIEPQHLHRLTERFyrvdkarSRDTGGSGLGLAIVKHALSH 404
Cdd:COG2972 344 LVENAIEHgiepKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-------SSKGEGRGIGLRNVRERLKL 416
|
90 100
....*....|....*....|....*..
gi 520910886 405 H---DSHLDIKSTVGVGSRFSFVLPKR 428
Cdd:COG2972 417 YygeEYGLEIESEPGEGTTVTIRIPLE 443
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
326-426 |
1.84e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 49.21 E-value: 1.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 326 ISNLVYNAVKYT----PPGAEINVRWFQTPQGACLEVEDKGDGIEPQHLHRLTERFYRvdkarSRDTGGSGLGLAIVKHA 401
Cdd:cd16915 5 VGNLIDNALDALaatgAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVS-----TKGQGERGIGLALVRQS 79
|
90 100
....*....|....*....|....*
gi 520910886 402 LSHHDSHLDIKSTVGVGSRFSFVLP 426
Cdd:cd16915 80 VERLGGSITVESEPGGGTTFSIRIP 104
|
|
| sensory_box |
TIGR00229 |
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ... |
98-203 |
2.06e-07 |
|
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]
Pssm-ID: 272971 [Multi-domain] Cd Length: 124 Bit Score: 49.60 E-value: 2.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 98 RRFRNGAESLPDAVVVFRSEGNIVWCNRLAQHLLGFRwPDDA-GQPISNLIrTPDFI----KYLQKDDFTEPLEMRSPLN 172
Cdd:TIGR00229 3 ERYRAIFESSPDAIIVIDLEGNILYVNPAFEEIFGYS-AEELiGRNVLELI-PEEDReevrERIERRLEGEPEPVSEERR 80
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 520910886 173 VERS------LELRIVP-YTEGEH---LMVVRDVTQLKQLE 203
Cdd:TIGR00229 81 VRRKdgseiwVEVSVSPiRTNGGElgvVGIVRDITERKEAE 121
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
92-203 |
9.42e-07 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 50.93 E-value: 9.42e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 92 ELTNLIRRFRNGAESLPDAVVVFRSEGNIVWCNRLAQHLLGFRWPDDAGQPISNLIRTPDFIKYLQKDDfTEPLEMRSPL 171
Cdd:COG3829 5 ELKELEEELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVTELIPNSPLLEVLKTGK-PVTGVIQKTG 83
|
90 100 110
....*....|....*....|....*....|....*.
gi 520910886 172 NVERSLELRIVP-YTEGEHLMVV---RDVTQLKQLE 203
Cdd:COG3829 84 GKGKTVIVTAIPiFEDGEVIGAVetfRDITELKRLE 119
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
98-157 |
2.01e-06 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 45.08 E-value: 2.01e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 98 RRFRNGAESLPDAVVVFRSEGNIVWCNRLAQHLLGFRWPDDAGQPISNLIRTPDFIKYLQ 157
Cdd:smart00091 1 ERLRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHPEDRERVQE 60
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
320-426 |
5.69e-06 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 45.29 E-value: 5.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 320 DQLRSAISNLVYNAVKYT---PPGAEINVRWFQTPQGACLEVEDKGDGIEPQHLhrlterfyrvdKARSRDTGGSGLGLA 396
Cdd:COG2172 33 DDLVLAVSEAVTNAVRHAyggDPDGPVEVELELDPDGLEIEVRDEGPGFDPEDL-----------PDPYSTLAEGGRGLF 101
|
90 100 110
....*....|....*....|....*....|
gi 520910886 397 IVKhALSHhdsHLDIKSTVGvGSRFSFVLP 426
Cdd:COG2172 102 LIR-RLMD---EVEYESDPG-GTTVRLVKR 126
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
254-428 |
7.97e-06 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 47.98 E-value: 7.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 254 NRMNSL--VNQLLTLSkieaspmhELEDVVDVPAMLEVLEKEAISLSGDDKHQLKFDIDkqlRVLADEDQLRS---AISN 328
Cdd:COG3920 338 NRIQALalVHELLYQS--------EDWEGVDLRDYLRELLEPLRDSYGGRGIRIELDGP---DVELPADAAVPlglILNE 406
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 329 LVYNAVKYTPPGAE---INVRWFQTPQGACLEVEDKGDGIEPQhlhrlterfyrVDKARSRdtggsGLGLAIVKHALSHH 405
Cdd:COG3920 407 LVTNALKHAFLSGEggrIRVSWRREDGRLRLTVSDNGVGLPED-----------VDPPARK-----GLGLRLIRALVRQL 470
|
170 180
....*....|....*....|...
gi 520910886 406 DSHLDIKSTVGVgsRFSFVLPKR 428
Cdd:COG3920 471 GGTLELDRPEGT--RVRITFPLA 491
|
|
| PAS_4 |
pfam08448 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
105-201 |
1.08e-05 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain is associated to signalling systems and works as a signal sensor domain. It recognizes differently substituted aromatic hydrocarbons, oxygen, different dodecanoic acids, autoinducers, 3,5-dimethyl-pyrazin-2-ol and N-alanyl-aminoacetone (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 312075 [Multi-domain] Cd Length: 110 Bit Score: 44.33 E-value: 1.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 105 ESLPDAVVVFRSEGNIVWCNRLAQHLLGFR------------WPDDAGQPISNLIRtpdfiKYLQKDDFTEPLEMRSPLN 172
Cdd:pfam08448 2 DSLPDALAVLDPDGRVRYANAAAAELFGLPpeellgktlaelLPPEDAARLERALR-----RALEGEEPIDFLEELLLNG 76
|
90 100 110
....*....|....*....|....*....|....
gi 520910886 173 VERSLELRIVPYTEGE-----HLMVVRDVTQLKQ 201
Cdd:pfam08448 77 EERHYELRLTPLRDPDgevigVLVISRDITERRR 110
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-426 |
1.10e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 44.31 E-value: 1.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 322 LRSAISNLVYNAVKYTPP-GAEINVRWFQTPQ----------GACLEVEDKGDGIEPQHLHRLterFYRVDKARSrdtGG 390
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGsGGEIILRTRTQRQvtlghprhrlALRVSVIDNGPGIPPDLQDTI---FYPMVSGRE---NG 74
|
90 100 110
....*....|....*....|....*....|....*.
gi 520910886 391 SGLGLAIVKHALSHHDSHLDIKSTVGvGSRFSFVLP 426
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGVIECDSQPG-HTVFSVSLP 109
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
107-196 |
1.28e-05 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 43.78 E-value: 1.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 107 LPDAVVVFRSEGNIVWCNRLAQHLLGFRWPDDAGQPISNLIRTPDFIKYLQK--------DDFTEPLEMRSPLNVERSLE 178
Cdd:cd00130 1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERlenllsggEPVTLEVRLRRKDGSVIWVL 80
|
90 100
....*....|....*....|...
gi 520910886 179 LRIVPYTEG-----EHLMVVRDV 196
Cdd:cd00130 81 VSLTPIRDEggeviGLLGVVRDI 103
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
326-426 |
1.29e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 43.92 E-value: 1.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 326 ISNLVYNAVK----YTPPGAEINVRWFQTPQGAC-LEVEDKGDGIEPQHLHRLTERFYRVDKArsrdtgGSGLGLAIVKH 400
Cdd:cd16920 5 LINLVRNGIEamseGGCERRELTIRTSPADDRAVtISVKDTGPGIAEEVAGQLFDPFYTTKSE------GLGMGLSICRS 78
|
90 100
....*....|....*....|....*.
gi 520910886 401 ALSHHDSHLDIKSTVGVGSRFSFVLP 426
Cdd:cd16920 79 IIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-425 |
1.49e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 43.60 E-value: 1.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 328 NLVYNAV----KYTPPGAEINVRWfqtpQG--ACLEVEDKGDGIEPQHLHRLTERFYRvdkarSRDTG-GSGLGLAIVKH 400
Cdd:cd16976 7 NLLQNALdamgKVENPRIRIAARR----LGgrLVLVVRDNGPGIAEEHLSRVFDPFFT-----TKPVGkGTGLGLSISYG 77
|
90 100
....*....|....*....|....*
gi 520910886 401 ALSHHDSHLDIKSTVGVGSRFSFVL 425
Cdd:cd16976 78 IVEEHGGRLSVANEEGAGARFTFDL 102
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
325-405 |
4.51e-05 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 41.87 E-value: 4.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 325 AISNLVYNAVKYT---PPGAEINVRWFQTPQGACLEVEDKGDGIEPqhlhrlterfyRVDKARSRDTGGSGLGLAIVkHA 401
Cdd:cd16936 4 AVSEAVTNAVRHAyrhDGPGPVRLELDLDPDRLRVEVTDSGPGFDP-----------LRPADPDAGLREGGRGLALI-RA 71
|
....
gi 520910886 402 LSHH 405
Cdd:cd16936 72 LMDE 75
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
105-426 |
4.67e-05 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 45.67 E-value: 4.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 105 ESLPDAVVVFRSEGNIVWCNRLAQHLLGFRwpddagQPISNLIRTPDFIKYLQKDDFTEPLEMRSPlnvERSLELRI--- 181
Cdd:PRK11086 228 QSIKEGVIAVDDRGEVTLINDEAKRLFNYK------KGLEDDPLGTDVESWMPVSRLKEVLRTGTP---RRDEEINIngr 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 182 ------VP-YTEGEhlmVV------RDVTQLKQL----EGMRrnFFANV----SHELRTPMTVLQGYLEMTEDPDmlVGP 240
Cdd:PRK11086 299 llltntVPvRVNGE---IIgaiatfRDKTEVRQLaqrlDGMV--NYADAlraqSHEFMNKLHVILGLLHLKSYDQ--LED 371
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 241 MWGK-AHGVMTEqlnrMNSLVNqlltlsKIEaSPmheledvvdVPAMLeVLEKeaISLSGDDKHQLKFDIDKQLRVLADE 319
Cdd:PRK11086 372 YILKtANNYQEE----IGSLLG------KIK-SP---------VIAGF-LLGK--ISRARELGITLIISEDSQLPDSGDE 428
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 320 DQ---LRSAISNLVYN---AVKYTPPGaEINVRW-FQTPQGAClEVEDKGDGIEPQHLHRLTERFYrvdkarSRDTGGSG 392
Cdd:PRK11086 429 DQvheLITILGNLIENaleAVGGEEGG-EISVSLhYRNGWLHC-EVSDDGPGIAPDEIDAIFDKGY------STKGSNRG 500
|
330 340 350
....*....|....*....|....*....|....
gi 520910886 393 LGLAIVKHALSHHDSHLDIKSTVGVGSRFSFVLP 426
Cdd:PRK11086 501 VGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIP 534
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
213-415 |
1.16e-04 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 44.29 E-value: 1.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 213 VSHELRTPMTVLQGYLEMTEDPDMLVGPMWGKAHGVMTEQL-NRMNSLVNQLLTLSKIEASPMHELEDVVDVPAMLEVLE 291
Cdd:COG4192 440 LAHELNQPLNAMSMYLFSAKKALEQENYAQLPTSLDKIEGLiERMDKIIKSLRQFSRKSDTPLQPVDLRQVIEQAWELVE 519
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 292 KEAISLsgddkhQLKFDIDKQLRVLADEDQLRSAISNLVYNAVKYTPPGAEINVRWFQTPQGACLEVEDKGDGIEPqhLH 371
Cdd:COG4192 520 SRAKPQ------QITLHIPDDLMVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGWPL--VD 591
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 520910886 372 RLTERFYrvdkarSRDTGGSGLGLAIVKHALSHHDSHLDIKSTV 415
Cdd:COG4192 592 KLFTPFT------TTKEVGLGLGLSICRSIMQQFGGDLYLASTL 629
|
|
| PAS_8 |
pfam13188 |
PAS domain; PAS domains are involved in many signalling proteins where they are used as a ... |
98-163 |
1.25e-04 |
|
PAS domain; PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. This domain recognizes oxygen and CO (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463802 [Multi-domain] Cd Length: 65 Bit Score: 39.84 E-value: 1.25e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 520910886 98 RRFRNGAESLPDAVVVFRSEGNIVWCNRLAQHLLGfrwPDDAGQPISNLIRTPDFIKYLQKDDFTE 163
Cdd:pfam13188 1 ERLRALFESSPDGILVLDEGGRIIYVNPAALELLG---YELLGELLGELLDLLDPLLEDALELLRE 63
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
199-423 |
1.29e-04 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 44.28 E-value: 1.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 199 LKQLEGmrrnffaNVSHELRTPMTVLQGYLE----MTEDPDMLVGPMwGKAHGVMTEQLNRMNSLVNQLLTLSKIEaspm 274
Cdd:PRK13557 163 LGQLTG-------GIAHDFNNLLQVMSGYLDviqaALSHPDADRGRM-ARSVENIRAAAERAATLTQQLLAFARKQ---- 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 275 hELED-VVDVPAMLEVLEKEAISLSGDDKhQLKFDIDKQL---RVlaDEDQLRSAISNLVYNAVKYTPPGAEINVR---- 346
Cdd:PRK13557 231 -RLEGrVLNLNGLVSGMGELAERTLGDAV-TIETDLAPDLwncRI--DPTQAEVALLNVLINARDAMPEGGRVTIRtrnv 306
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 347 ---------WFQTPQG--ACLEVEDKGDGIEPQHLHRLTERFYRvdkarSRDTG-GSGLGLAIVKHALSHHDSHLDIKST 414
Cdd:PRK13557 307 eiededlamYHGLPPGryVSIAVTDTGSGMPPEILARVMDPFFT-----TKEEGkGTGLGLSMVYGFAKQSGGAVRIYSE 381
|
250
....*....|.
gi 520910886 415 VGVGS--RFSF 423
Cdd:PRK13557 382 VGEGTtvRLYF 392
|
|
| HATPase_YehU-like |
cd16956 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
325-426 |
1.89e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.
Pssm-ID: 340432 [Multi-domain] Cd Length: 101 Bit Score: 40.50 E-value: 1.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 325 AISNLVYNAVKY----TPPGAEINVRWFQTPQGACLEVEDKGDGIEPqhlhrlterfyrVDKARSRDTGGSGLGLAIVKH 400
Cdd:cd16956 5 TLQPIVENAVKHglsgLLDGGRVEITARLDGQHLLLEVEDNGGGMDP------------DTLARILIRSSNGLGLNLVDK 72
|
90 100
....*....|....*....|....*....
gi 520910886 401 ALSH---HDSHLDIKSTVGVGSRFSFVLP 426
Cdd:cd16956 73 RLRQafgNDYGLDIECAPGEGTRITIRLP 101
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|
| TyrR |
COG3283 |
Transcriptional regulator TyrR of aromatic amino acids metabolism [Transcription, Amino acid ... |
105-161 |
4.99e-04 |
|
Transcriptional regulator TyrR of aromatic amino acids metabolism [Transcription, Amino acid transport and metabolism];
Pssm-ID: 442513 [Multi-domain] Cd Length: 514 Bit Score: 42.10 E-value: 4.99e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 520910886 105 ESLPDAVVVFRSEGNIVWCNRLAQHLLGFRWPDDAGQPISNLIRTPDFIKYLQKDDF 161
Cdd:COG3283 87 EALPDPVFSIDLKGKIELANPAALSLLGLSEEELIGQPLSELLKGFNFSRWLESNEP 143
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|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
325-426 |
7.06e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 38.95 E-value: 7.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 325 AISNLVYNAVKYT----PPGAEINVRWFQTPQGACLEVEDKGDGIEPQHLHRLTERFYrvdkarsrdTGGSGLGLAIVK- 399
Cdd:cd16957 5 ALQVLVENAIRHAfpkrKENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGKTTV---------TSEKGTGTALENl 75
|
90 100 110
....*....|....*....|....*....|.
gi 520910886 400 ----HALSHHDSHLDIKSTVGVGSRFSFVLP 426
Cdd:cd16957 76 nrrlIGLFGSEACLHIESEVHGGTEVWFVIP 106
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| HATPase_YpdA-YehU-LytS-like |
cd16924 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
329-426 |
8.76e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340401 [Multi-domain] Cd Length: 103 Bit Score: 38.58 E-value: 8.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 329 LVYNAVKY-----TPPGA-EINVRwfQTPQGACLEVEDKGDGIEPQHLHRLTErfyrvdkarsRDTGGSGLGLAIVKHAL 402
Cdd:cd16924 9 LVENAIQHglsplTDKGVvTISAL--KEDNHVMIEVEDNGRGIDPKVLNILGK----------KPKEGNGIGLYNVHQRL 76
|
90 100
....*....|....*....|....*..
gi 520910886 403 SH---HDSHLDIKSTVGVGSRFSFVLP 426
Cdd:cd16924 77 ILlfgEDYGIHIASEPDKGTRITFTIP 103
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| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
312-426 |
2.12e-03 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 39.60 E-value: 2.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 312 QLRVLADEDQLRSAISNLVY--------NAVKYTPpGAEINVRWFQTPQGACLEVEDKGDGIEPQhlhrlterfyrvdka 383
Cdd:COG4585 145 ELDVDGDPDRLPPEVELALYrivqealtNALKHAG-ATRVTVTLEVDDGELTLTVRDDGVGFDPE--------------- 208
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 520910886 384 rsrDTGGSGLGLAIVKHALSHHDSHLDIKSTVGVGSRFSFVLP 426
Cdd:COG4585 209 ---AAPGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLP 248
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|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
320-426 |
2.81e-03 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 38.72 E-value: 2.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 320 DQLRSAISNLVYNAV------------KYTPPGAEINVRWFQTPQGACLEVEDKGDGIEPQH-LHRLTERFYRVDKARSR 386
Cdd:cd16916 37 EKLADPLTHLLRNAVdhgieapeerlaAGKPPEGTITLRAEHQGNQVVIEVSDDGRGIDREKiREKAIERGLITADEAAT 116
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 520910886 387 ----------------------DTGGSGLGLAIVKHALSHHDSHLDIKSTVGVGSRFSFVLP 426
Cdd:cd16916 117 lsddevlnlifapgfstaeqvtDVSGRGVGMDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
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|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
332-426 |
4.29e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 35.99 E-value: 4.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520910886 332 NAVKYTPpGAEINVRWFQTPQGACLEVEDKGDGIEPqhlhrlterfyrvdkarSRDTGGSGLGLAIVKHALSHHDSHLDI 411
Cdd:cd16917 11 NALKHAG-ASRVRVTLSYTADELTLTVVDDGVGFDG-----------------PAPPGGGGFGLLGMRERAELLGGTLTI 72
|
90
....*....|....*
gi 520910886 412 KSTVGVGSRFSFVLP 426
Cdd:cd16917 73 GSRPGGGTRVTARLP 87
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