|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10764 |
PRK10764 |
potassium-tellurite ethidium and proflavin transporter; Provisional |
7-303 |
1.37e-158 |
|
potassium-tellurite ethidium and proflavin transporter; Provisional
Pssm-ID: 236756 Cd Length: 324 Bit Score: 446.32 E-value: 1.37e-158
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 7 PRQVLNLPAGYFGMVLGTIGMGFAWRYASTLWPVSRSIGDGLVTLAMAMWVLLSMAFISRAIRFPASVLREMRHPVSSSF 86
Cdd:PRK10764 3 SDKVLPLPAGYFGIVLGLIGLGFAWRYAAQLWPLPAWIGEALVALASIIWALLILAYLYKWIRFPESVLAELRHPVQSSF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 87 VSLFPATTLLVAIGLAPWCRPLAIGLFVPGVALQLAYAAWQSGGLWRGNHPREATTPGLYLPTVANNFISAMACGALGFS 166
Cdd:PRK10764 83 VSLIPITTMLVAIGLVPYSRPLAVVLFSFGVVGQLAFAAWRTAGLWRGGHPEEATTPGLYLPTVANNFVSAMALGALGYH 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 167 DAGLVFLGAGVFSWLSLEPAILQRLRSAGELPTPLRTSLGIQLAPALVACCAWLSVNGGEADTFAKLLFGYGLLQLLFML 246
Cdd:PRK10764 163 DAGLLFLGAGVFSWLSLEPVILQRLRSSGELPTALRPSLGIQLAPAFVGCSAYLSVNGGEGDTLAKMLFGYGLLQLLFLL 242
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 520902619 247 RLMPWYLRQPFNASFWSFSFGISALATTGLHLGQARGDGFFHHLAMPLFIFSNLVVG 303
Cdd:PRK10764 243 RLMPWILSQGFNASFWSFSFGVAALATTGLHLGHGSDNGFFHTLAVPLFIFANFIIA 299
|
|
| TDT_TehA |
cd09324 |
Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; This ... |
14-303 |
6.63e-125 |
|
Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; This subfamily includes Tellurite resistance protein TehA that belongs to the C4-dicarboxylate transporter/malic acid transport (TDT) protein family and is a homolog of plant Slow Anion Channel-Associated 1 (SLAC1). The tehA gene encodes an integral membrane protein that has been shown to have efflux activity of quaternary ammonium compounds. TehA protein of Escherichia coli functions as a tellurite-resistance uptake permease.
Pssm-ID: 187764 Cd Length: 301 Bit Score: 360.04 E-value: 6.63e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 14 PAGYFGMVLGTIGMGFAWRYASTLWPVSRSIGDGLVTLAMAMWVLLSMAFISRAIRFPASVLREMRHPVSSSFVSLFPAT 93
Cdd:cd09324 1 PVGYFGIVLGLAALGLAWRYAAQLWPLPAIVGESLLALASVVWLLLIGAYAYKWLKYREEARAELRHPVQCCFISLIPIT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 94 TLLVAIGLAPWCRPLAIGLFVPGVALQLAYAAWQSGGLWRGNHPREATTPGLYLPTVANNFISAMACGALGFSDAGLVFL 173
Cdd:cd09324 81 TMLVGIALYPYSRLLAEVLIVLGIIGQLAFAAWRTGGLWQGGHFPEATTPVLYLPTVAGNFVSASALAALGYHDLGMLFF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 174 GAGVFSWLSLEPAILQRLRSAGELPTPLRTSLGIQLAPALVACCAWLSVNGGEADTFAKLLFGYGLLQLLFMLRLMPWYL 253
Cdd:cd09324 161 GAGMFSWLSLEPVILQRLRTSPPLPPALRPTLGIQLAPAFVGCSAYLSLNGGEVDLLAKMLWGYGLLQLLFLLRLLPWIA 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 520902619 254 RQPFNASFWSFSFGISALATTGLHLGQARGDGFFHHLAMPLFIFSNLVVG 303
Cdd:cd09324 241 EQGFSMGFWAFSFGLAAMATSGLHLYHGGVLGPLSLLALALFNVANGLIA 290
|
|
| tdt |
TIGR00816 |
C4-dicarboxylate transporter/malic acid transport protein; The Tellurite-Resistance ... |
13-303 |
1.14e-81 |
|
C4-dicarboxylate transporter/malic acid transport protein; The Tellurite-Resistance/Dicarboxylate Transporter (TDT) Family (TC 2.A.16)Two members of the TDT family have been functionally characterized. One is the TehA protein of E. coli which has been implicated in resistance to tellurite; the other is the Mae1 protein of S. pombe which functions in the uptake of malate and other dicarboxylates by a proton symportmechanism. These proteins exhibit 10 putative transmembrane a-helicalspanners (TMSs). [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273285 Cd Length: 320 Bit Score: 250.78 E-value: 1.14e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 13 LPAGYFGMVLGTIGMGFAWRYASTLWPVSRSIGDGLVTLAMAMWVLLSMAFISRAIRFPASVLREMRHPVSSSFVSLFPA 92
Cdd:TIGR00816 1 FPWGWFAIVLGTGGLALASLSYSFYLPILKDLSDVLFILAIALFFLFTSCWLARLIRYPSNVLAELKHPVLSSFIPLIPI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 93 TTLLVAIGLAPWCRPLAIGLFVPGVALQLAYAAWQSGGLWRGN-HPREATTPGLYLPTVANNFISAMACGALGFSDAGL- 170
Cdd:TIGR00816 81 STMLLGIDFIIWGYPLALGLWYIGAIGQLLFSVIVPFYLFKNEsIEIEHTHPGWYLPPVALIFISAAALAILPYLTHELt 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 171 ----VFLGAGVFSWLSLEPAILQRLRSAGELPTPLRTSLGIQLAPALVACCAWLS-VNGGEADT-------FAKLLFGYG 238
Cdd:TIGR00816 161 vlfyFGWGAGFFLYLSLEAVLLLRLRLHGLLPSALRPTMFINLAPIGVGIVALINiVNHGEFITikepfliLAIILWGFG 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 520902619 239 LLQLLFMLRLMPWYLRQ--PFNASFWSFSFGISALATTGLHLGQARGDGFFHHLAMPLFIFSNLVVG 303
Cdd:TIGR00816 241 LWQLLFAIRLLLWYVKLklPFAMGWWAFIFPLAAYANSTHLVYKGFDFKVFQYIGFGLYVFLNFFWA 307
|
|
| TehA |
COG1275 |
Tellurite resistance protein TehA and related permeases [Defense mechanisms]; |
3-303 |
2.55e-79 |
|
Tellurite resistance protein TehA and related permeases [Defense mechanisms];
Pssm-ID: 440886 Cd Length: 323 Bit Score: 244.76 E-value: 2.55e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 3 KTQTPRQVLNLPAGYFGMVLGTIGMGFAWRYASTLWPVSRSIGDGLVTLAMAMWVLLSMAFISRAIRFPASVLREMRHPV 82
Cdd:COG1275 2 STAPRSRLRNLPPAWFALVMGTGGLGLAWRLAAALLPGPAAIAEVLLALAALLFLVLLLLYLLKWLRYPAAVRADLRHPV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 83 SSSFVSLFPATTLLVAIGLAPWCRPLAIGLFVPGVALQLAYAAWQSGGLWRGNHPR-EATTPGLYLPTVANNFISAMACG 161
Cdd:COG1275 82 RGSFFPTIPMALLLLGTGLLPLAPALALVLWLLGVALHLALTVYFPYRLFTGEKFEiEHITPAWFIPVVGNIVVAVAGAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 162 ALGFSDAGLVFLGAGVFSWLSLEPAILQRLRSAGELPTPLRTSLGIQLAPALVACCAWLSVNGGEADTFAKLLFGYGLLQ 241
Cdd:COG1275 162 LGPLLELSYAFFGVGLFLYLVLLPLVLYRLIFHKPLPEALRPTLWILLAPPAVGLLAYLALGGGPLDGFALILWGFGLWW 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 520902619 242 LLFMLRLMPWYLRQPFNASFWSFSFGISALATTGLHLGQARGDGFFHHLAMPLFIFSNLVVG 303
Cdd:COG1275 242 LLLLLLLTPRLLRLPFSPSWWAFTFPLAAYATATLRLAEATGLPFLAVLALALLVLATLVWL 303
|
|
| SLAC1 |
pfam03595 |
Voltage-dependent anion channel; This family of transporters has ten alpha helical ... |
12-301 |
5.84e-34 |
|
Voltage-dependent anion channel; This family of transporters has ten alpha helical transmembrane segments. The structure of a bacterial homolog of SLAC1 shows it to have a trimeric arrangement. The pore is composed of five helices with a conserved Phe residue involved in gating. One homolog, Mae1 from the yeast Schizosaccharomyces pombe, functions as a malate uptake transporter; another, Ssu1 from Saccharomyces cerevisiae and other fungi including Aspergillus fumigatus, is characterized as a sulfite efflux pump; and TehA from Escherichia coli is identified as a tellurite resistance protein by virtue of its association in the tehA/tehB operon. In plants, this family is found in the stomatal guard cells functioning as an anion-transporting pore. Many homologs are incorrectly annotated as tellurite resistance or dicarboxylate transporter (TDT) proteins.
Pssm-ID: 460983 Cd Length: 321 Bit Score: 126.97 E-value: 5.84e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 12 NLPAGYFGMVLGTIGMGFAWRYAStLWPVSRSIGDGLVTLAMAMWVLLSMAFISRAIRFPASVLREMRHPVSSSFVSLFP 91
Cdd:pfam03595 1 HFTPAWFAIVMGTGGLALLLHHLP-YGRGLRTIGLILFILNLVLFLLLLLLYLLRFILYPEAVRAELRHPVESLFLGTFP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 92 ATTLLVAIGLA------PWCRPLAIGLFVP-GVALQLAYAAWQSGGLWRGNHPREATTPGLYLPTVANNFISAMA----C 160
Cdd:pfam03595 80 MGFATIINGLVlvpvpgPWLVTLAWVLWWWiGVALALAFAVGVPFLLFTRHHLLEAMTPAWLLPVVPLMVVAALGallaA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 161 GALGFSDAGLVFLGAGVFSWLSLEPAILQRLRSAGELPTPLRTSLGIQLAPALVACCAWLSVNGGEADTFAKLLFGYGLL 240
Cdd:pfam03595 160 LLLPILVVSYLLWGLGLFLALVILAIYLYRLFTHGLPPAELRPSLFIPLGPPGQGALALLLLGGAAPTILPALTALAGEI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 241 QLLFMLRL---------------------MPWYLRQPFNASFWSFSFGISALATTGLHLGQARGDGFFHHLAMPLFIFSN 299
Cdd:pfam03595 240 LYVVALLLalflwgfglwwffiaalsvlsALRRGGLPFNLGWWAFTFPLGAFALATIELGKALDSPFFRVLGTILSVLLV 319
|
..
gi 520902619 300 LV 301
Cdd:pfam03595 320 LV 321
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10764 |
PRK10764 |
potassium-tellurite ethidium and proflavin transporter; Provisional |
7-303 |
1.37e-158 |
|
potassium-tellurite ethidium and proflavin transporter; Provisional
Pssm-ID: 236756 Cd Length: 324 Bit Score: 446.32 E-value: 1.37e-158
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 7 PRQVLNLPAGYFGMVLGTIGMGFAWRYASTLWPVSRSIGDGLVTLAMAMWVLLSMAFISRAIRFPASVLREMRHPVSSSF 86
Cdd:PRK10764 3 SDKVLPLPAGYFGIVLGLIGLGFAWRYAAQLWPLPAWIGEALVALASIIWALLILAYLYKWIRFPESVLAELRHPVQSSF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 87 VSLFPATTLLVAIGLAPWCRPLAIGLFVPGVALQLAYAAWQSGGLWRGNHPREATTPGLYLPTVANNFISAMACGALGFS 166
Cdd:PRK10764 83 VSLIPITTMLVAIGLVPYSRPLAVVLFSFGVVGQLAFAAWRTAGLWRGGHPEEATTPGLYLPTVANNFVSAMALGALGYH 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 167 DAGLVFLGAGVFSWLSLEPAILQRLRSAGELPTPLRTSLGIQLAPALVACCAWLSVNGGEADTFAKLLFGYGLLQLLFML 246
Cdd:PRK10764 163 DAGLLFLGAGVFSWLSLEPVILQRLRSSGELPTALRPSLGIQLAPAFVGCSAYLSVNGGEGDTLAKMLFGYGLLQLLFLL 242
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 520902619 247 RLMPWYLRQPFNASFWSFSFGISALATTGLHLGQARGDGFFHHLAMPLFIFSNLVVG 303
Cdd:PRK10764 243 RLMPWILSQGFNASFWSFSFGVAALATTGLHLGHGSDNGFFHTLAVPLFIFANFIIA 299
|
|
| TDT_TehA |
cd09324 |
Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; This ... |
14-303 |
6.63e-125 |
|
Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; This subfamily includes Tellurite resistance protein TehA that belongs to the C4-dicarboxylate transporter/malic acid transport (TDT) protein family and is a homolog of plant Slow Anion Channel-Associated 1 (SLAC1). The tehA gene encodes an integral membrane protein that has been shown to have efflux activity of quaternary ammonium compounds. TehA protein of Escherichia coli functions as a tellurite-resistance uptake permease.
Pssm-ID: 187764 Cd Length: 301 Bit Score: 360.04 E-value: 6.63e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 14 PAGYFGMVLGTIGMGFAWRYASTLWPVSRSIGDGLVTLAMAMWVLLSMAFISRAIRFPASVLREMRHPVSSSFVSLFPAT 93
Cdd:cd09324 1 PVGYFGIVLGLAALGLAWRYAAQLWPLPAIVGESLLALASVVWLLLIGAYAYKWLKYREEARAELRHPVQCCFISLIPIT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 94 TLLVAIGLAPWCRPLAIGLFVPGVALQLAYAAWQSGGLWRGNHPREATTPGLYLPTVANNFISAMACGALGFSDAGLVFL 173
Cdd:cd09324 81 TMLVGIALYPYSRLLAEVLIVLGIIGQLAFAAWRTGGLWQGGHFPEATTPVLYLPTVAGNFVSASALAALGYHDLGMLFF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 174 GAGVFSWLSLEPAILQRLRSAGELPTPLRTSLGIQLAPALVACCAWLSVNGGEADTFAKLLFGYGLLQLLFMLRLMPWYL 253
Cdd:cd09324 161 GAGMFSWLSLEPVILQRLRTSPPLPPALRPTLGIQLAPAFVGCSAYLSLNGGEVDLLAKMLWGYGLLQLLFLLRLLPWIA 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 520902619 254 RQPFNASFWSFSFGISALATTGLHLGQARGDGFFHHLAMPLFIFSNLVVG 303
Cdd:cd09324 241 EQGFSMGFWAFSFGLAAMATSGLHLYHGGVLGPLSLLALALFNVANGLIA 290
|
|
| tdt |
TIGR00816 |
C4-dicarboxylate transporter/malic acid transport protein; The Tellurite-Resistance ... |
13-303 |
1.14e-81 |
|
C4-dicarboxylate transporter/malic acid transport protein; The Tellurite-Resistance/Dicarboxylate Transporter (TDT) Family (TC 2.A.16)Two members of the TDT family have been functionally characterized. One is the TehA protein of E. coli which has been implicated in resistance to tellurite; the other is the Mae1 protein of S. pombe which functions in the uptake of malate and other dicarboxylates by a proton symportmechanism. These proteins exhibit 10 putative transmembrane a-helicalspanners (TMSs). [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273285 Cd Length: 320 Bit Score: 250.78 E-value: 1.14e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 13 LPAGYFGMVLGTIGMGFAWRYASTLWPVSRSIGDGLVTLAMAMWVLLSMAFISRAIRFPASVLREMRHPVSSSFVSLFPA 92
Cdd:TIGR00816 1 FPWGWFAIVLGTGGLALASLSYSFYLPILKDLSDVLFILAIALFFLFTSCWLARLIRYPSNVLAELKHPVLSSFIPLIPI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 93 TTLLVAIGLAPWCRPLAIGLFVPGVALQLAYAAWQSGGLWRGN-HPREATTPGLYLPTVANNFISAMACGALGFSDAGL- 170
Cdd:TIGR00816 81 STMLLGIDFIIWGYPLALGLWYIGAIGQLLFSVIVPFYLFKNEsIEIEHTHPGWYLPPVALIFISAAALAILPYLTHELt 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 171 ----VFLGAGVFSWLSLEPAILQRLRSAGELPTPLRTSLGIQLAPALVACCAWLS-VNGGEADT-------FAKLLFGYG 238
Cdd:TIGR00816 161 vlfyFGWGAGFFLYLSLEAVLLLRLRLHGLLPSALRPTMFINLAPIGVGIVALINiVNHGEFITikepfliLAIILWGFG 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 520902619 239 LLQLLFMLRLMPWYLRQ--PFNASFWSFSFGISALATTGLHLGQARGDGFFHHLAMPLFIFSNLVVG 303
Cdd:TIGR00816 241 LWQLLFAIRLLLWYVKLklPFAMGWWAFIFPLAAYANSTHLVYKGFDFKVFQYIGFGLYVFLNFFWA 307
|
|
| TehA |
COG1275 |
Tellurite resistance protein TehA and related permeases [Defense mechanisms]; |
3-303 |
2.55e-79 |
|
Tellurite resistance protein TehA and related permeases [Defense mechanisms];
Pssm-ID: 440886 Cd Length: 323 Bit Score: 244.76 E-value: 2.55e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 3 KTQTPRQVLNLPAGYFGMVLGTIGMGFAWRYASTLWPVSRSIGDGLVTLAMAMWVLLSMAFISRAIRFPASVLREMRHPV 82
Cdd:COG1275 2 STAPRSRLRNLPPAWFALVMGTGGLGLAWRLAAALLPGPAAIAEVLLALAALLFLVLLLLYLLKWLRYPAAVRADLRHPV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 83 SSSFVSLFPATTLLVAIGLAPWCRPLAIGLFVPGVALQLAYAAWQSGGLWRGNHPR-EATTPGLYLPTVANNFISAMACG 161
Cdd:COG1275 82 RGSFFPTIPMALLLLGTGLLPLAPALALVLWLLGVALHLALTVYFPYRLFTGEKFEiEHITPAWFIPVVGNIVVAVAGAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 162 ALGFSDAGLVFLGAGVFSWLSLEPAILQRLRSAGELPTPLRTSLGIQLAPALVACCAWLSVNGGEADTFAKLLFGYGLLQ 241
Cdd:COG1275 162 LGPLLELSYAFFGVGLFLYLVLLPLVLYRLIFHKPLPEALRPTLWILLAPPAVGLLAYLALGGGPLDGFALILWGFGLWW 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 520902619 242 LLFMLRLMPWYLRQPFNASFWSFSFGISALATTGLHLGQARGDGFFHHLAMPLFIFSNLVVG 303
Cdd:COG1275 242 LLLLLLLTPRLLRLPFSPSWWAFTFPLAAYATATLRLAEATGLPFLAVLALALLVLATLVWL 303
|
|
| TDT_TehA_like |
cd09322 |
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA proteins; The ... |
17-303 |
1.16e-74 |
|
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA proteins; The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes members from all three kingdoms, but only three members of the family have been functionally characterized: the TehA protein of E. coli functioning as a tellurite-resistance uptake permease, the Mae1 protein of S. pombe functioning in the uptake of malate and other dicarboxylates, and the sulfite efflux pump (SSU1) of Saccharomyces cerevisiae. In plants, the plasma membrane protein SLAC1 (Slow Anion Channel-Associated 1), which is preferentially expressed in guard cells, encodes a distant homolog of fungal and bacterial dicarboxylate/malic acid transport proteins. SLAC1 is essential in mediating stomatal responses to physiological and stress stimuli. Members of the TDT family exhibit 10 putative transmembrane a-helical spanners (TMSs).
Pssm-ID: 187762 Cd Length: 289 Bit Score: 231.66 E-value: 1.16e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 17 YFGMVLGTIGMGFAWRYASTLWPVSRSIGDGLVTLAMAMWVLLSMAFISRAIRFPASVLREMRHPVSSSFVSLFPATTLL 96
Cdd:cd09322 1 LFPIVLGLLGLGLAWLGALLLLGLPSIVGEILGILALLLWLLLLLKYLLKLLRYPEAVKAELRHPVRASFFATFSMSLML 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 97 VAIGLAPWCRPLAIGLFVPGVALQLAYAAWQSGGLWRGNHPREATTPGLYLPTVANNFISAMACgALGFSDAGLVFLGAG 176
Cdd:cd09322 81 LSIYLLPYSPLLARVLWILGAVLHLVFTLYFVSRWIRGGKFLEHVTPSWFIPYVGNIVVPVTGP-ALGGPELGWFFFGVG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 177 VFSWLSLEPAILQRLRSAGELPTPLRTSLGIQLAPALVACCAWLSVNGGEADTFAKLLFGYGLLQLLFMLRLMPWYLRQP 256
Cdd:cd09322 160 LIFWLVLLPLVLYRLIFHEPLPEPLRPTLAILLAPPSLGLAAYLALFGGPIDLFALILLGLALFLFLLLLRLLPRLLKLP 239
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 520902619 257 FNASFWSFSFGISALATTGLHLGQARGDGFFHHLAMPLFIFSNLVVG 303
Cdd:cd09322 240 FSPSWWAFTFPLAALAIALLKMAAYLGSGFLQLLALVLLELLTAVIL 286
|
|
| TDT_SLAC1_like |
cd09323 |
Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion ... |
12-303 |
5.58e-50 |
|
Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); SLAC1 (Slow Anion Channel-Associated 1) is a plasma membrane protein, preferentially expressed in guard cells, which encodes a distant homolog of fungal and bacterial dicarboxylate/malic acid transport proteins. It is essential for stomatal closure in response to carbon dioxide, abscisic acid, ozone, light/dark transitions, humidity change, calcium ions, hydrogen peroxide and nitric oxide. In the Arabidopsis genome, SLAC1 is part of a gene family with five members and encodes a membrane protein that has ten putative transmembrane domains flanked by large N- and C-terminal domains. Mutations in SLAC1 impair slow (S-type) anion channel currents that are activated by cytosolic calcium ions and abscisic acid, but do not affect rapid (R-type) anion channel currents or calcium ion channel function.
Pssm-ID: 187763 Cd Length: 297 Bit Score: 168.49 E-value: 5.58e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 12 NLPAGYFGMVLGTIGMGFAWRYASTLWPVSRSIGDGLVTLAMAMWVLLSMAFISRAIRFPASVLREMRHPVSSSFVSLFP 91
Cdd:cd09323 1 HFPVSLFAIVMGLSGLALAWRKAAELLGLPAAISEALGWLAVAVFVVLAALYALKILRYPEAVKAEFNHPVRINFFPAIS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 92 ATTLLVAIGLAPWCRPLAIGLFVPGVALQLAYAAWQSGGLWRGNHPREAT-TPGLYLPTVAnNFISAMACGALGFSDAGL 170
Cdd:cd09323 81 ISLLLLSIALLPYSPVLALALWIIGAVLQLALTLYVVSRWISHRQFQIGHaNPAWFIPVVG-NLVVPIAGVPLGYAEVSW 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 171 VFLGAGVFSWLSLEPAILQRLRSAGELPTPLRTSLGIQLAPALVACCAWLSVNgGEADTFAKLLFGYGLLQLLFMLRLMP 250
Cdd:cd09323 160 FFFSVGLFFWLVLFTIVFNRLIFHEPLPAKLLPTLFILIAPPAVGFLAYLKLT-GSLDAFARILYYIALFLFLLLLFQVR 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 520902619 251 WYLRQPFNASFWSFSFGISALATTGLHLGQARGDGFFHHLAMPLFIFSNLVVG 303
Cdd:cd09323 239 RFRKLPFFLSWWAYSFPLAALAIATLRMAELTGSLFLQVLALVLLALLTLVVA 291
|
|
| SLAC1 |
pfam03595 |
Voltage-dependent anion channel; This family of transporters has ten alpha helical ... |
12-301 |
5.84e-34 |
|
Voltage-dependent anion channel; This family of transporters has ten alpha helical transmembrane segments. The structure of a bacterial homolog of SLAC1 shows it to have a trimeric arrangement. The pore is composed of five helices with a conserved Phe residue involved in gating. One homolog, Mae1 from the yeast Schizosaccharomyces pombe, functions as a malate uptake transporter; another, Ssu1 from Saccharomyces cerevisiae and other fungi including Aspergillus fumigatus, is characterized as a sulfite efflux pump; and TehA from Escherichia coli is identified as a tellurite resistance protein by virtue of its association in the tehA/tehB operon. In plants, this family is found in the stomatal guard cells functioning as an anion-transporting pore. Many homologs are incorrectly annotated as tellurite resistance or dicarboxylate transporter (TDT) proteins.
Pssm-ID: 460983 Cd Length: 321 Bit Score: 126.97 E-value: 5.84e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 12 NLPAGYFGMVLGTIGMGFAWRYAStLWPVSRSIGDGLVTLAMAMWVLLSMAFISRAIRFPASVLREMRHPVSSSFVSLFP 91
Cdd:pfam03595 1 HFTPAWFAIVMGTGGLALLLHHLP-YGRGLRTIGLILFILNLVLFLLLLLLYLLRFILYPEAVRAELRHPVESLFLGTFP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 92 ATTLLVAIGLA------PWCRPLAIGLFVP-GVALQLAYAAWQSGGLWRGNHPREATTPGLYLPTVANNFISAMA----C 160
Cdd:pfam03595 80 MGFATIINGLVlvpvpgPWLVTLAWVLWWWiGVALALAFAVGVPFLLFTRHHLLEAMTPAWLLPVVPLMVVAALGallaA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 161 GALGFSDAGLVFLGAGVFSWLSLEPAILQRLRSAGELPTPLRTSLGIQLAPALVACCAWLSVNGGEADTFAKLLFGYGLL 240
Cdd:pfam03595 160 LLLPILVVSYLLWGLGLFLALVILAIYLYRLFTHGLPPAELRPSLFIPLGPPGQGALALLLLGGAAPTILPALTALAGEI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 241 QLLFMLRL---------------------MPWYLRQPFNASFWSFSFGISALATTGLHLGQARGDGFFHHLAMPLFIFSN 299
Cdd:pfam03595 240 LYVVALLLalflwgfglwwffiaalsvlsALRRGGLPFNLGWWAFTFPLGAFALATIELGKALDSPFFRVLGTILSVLLV 319
|
..
gi 520902619 300 LV 301
Cdd:pfam03595 320 LV 321
|
|
| TDT |
cd09299 |
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance ... |
17-277 |
3.84e-16 |
|
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes members from all three kingdoms, but only three members of the family have been functionally characterized: the TehA protein of E. coli functioning as a tellurite-resistance uptake permease, the Mae1 protein of S. pombe functioning in the uptake of malate and other dicarboxylates, and the sulfite efflux pump (SSU1) of Saccharomyces cerevisiae. In plants, the plasma membrane protein SLAC1 (Slow Anion Channel-Associated 1), which is preferentially expressed in guard cells, encodes a distant homolog of fungal and bacterial dicarboxylate/malic acid transport proteins. SLAC1 is essential in mediating stomatal responses to physiological and stress stimuli. Members of the TDT family exhibit 10 putative transmembrane alpha-helical spanners (TMSs).
Pssm-ID: 187756 Cd Length: 326 Bit Score: 77.75 E-value: 3.84e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 17 YFGMVLGTIGMGFAWRYASTLWPVSRSIGDGLVTLAMAMWVLLSMAFISRAIRFPASVLREMRH-PVSSSFVSLFPATTL 95
Cdd:cd09299 1 WFGIVMGTGILSLALYLLPYQFPGLRIIGKILFILAIVIFILFFALWLLRLIRYPRHVVRESHHnPVEASFLAAVPISLF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 96 LVAIGLAPWCRP--------LAIGLFVPGVALQLAYAAWQSGGLWRGNHP-REATTPGLYLPTVA---NNFISAMACGAL 163
Cdd:cd09299 81 TIIDFLALYGGAntgrlvilIAYVLWWIGLALSLVSAVGVPYLLFTNHVYeIEHISPAWLLPIVPpmtSAALAGALLPYS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 164 GFSDA-------GLVFLGAGVFSWLSLEPAILQRLRSAGELPTPLRTSLGIQLAPALVACCAWLSVNGG----------- 225
Cdd:cd09299 161 PGGAIqlsviflGYLFFGIGFFLFIFIGAIIFSRLVINKLPPGQLAPTLMIVLGPMGQSIFALLLLGKNarlifflyasf 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 520902619 226 ---EADTFAKLLFGYGLLQLLFMLRLMPWYL--RQPFNASFWSFSF--GISALATTGLH 277
Cdd:cd09299 241 lqaLAVFASIILWGFGLWWLLLALVSILRTLrkKLPFSLGWWSYVFplGVYTNGTYALY 299
|
|
| TDT_like_3 |
cd09321 |
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance ... |
16-297 |
7.55e-16 |
|
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes members from all three kingdoms, but only three members of the family have been functionally characterized: the TehA protein of E. coli functioning as a tellurite-resistance uptake permease, the Mae1 protein of S. pombe functioning in the uptake of malate and other dicarboxylates, and the sulfite efflux pump (SSU1) of Saccharomyces cerevisiae. In plants, the plasma membrane protein SLAC1 (Slow Anion Channel-Associated 1), which is preferentially expressed in guard cells, encodes a distant homolog of fungal and bacterial dicarboxylate/malic acid transport proteins. SLAC1 is essential in mediating stomatal responses to physiological and stress stimuli. Members of the TDT family exhibit 10 putative transmembrane a-helical spanners (TMSs).
Pssm-ID: 187761 Cd Length: 327 Bit Score: 76.96 E-value: 7.55e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 16 GYFGMVLGTIGMGFAWRYASTLWPVSRSIGDGLVTLAMAMWVLLSMAFISRAIRFPASVLREMRHPVSSSFVSLFPATTL 95
Cdd:cd09321 4 SWFASVMGTGALAIASYLYSAYFPFLKTLAVFLTYLNFLLFFVLLVPWLLRWILYPKEALADLKHPVLSNFYPTMPIALL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 96 LVA-----IGLAPWCRPLAIGLFVPGVALQLAYAAWQSGGLWRGNH-PREATTPGLYLPTVAN-------NFISAMACGA 162
Cdd:cd09321 84 VLAtniliVGQGPLGYSLALTLWILGSILIFIFSFIVSYIMFINEEiPIEHINPAWFIPPVGLiviplagNFLIPHFPGA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 163 LGFSDA--GLVFLGAGVFSWLSLEPAILQRLRSAGELPTPLRTSLGIQLAPALVACCAWLS-VNGGEADT---------- 229
Cdd:cd09321 164 WQESILviNLFGFGIGFFLFLFLLAIILHRLILHEPPPPELAPTFWINLAPIGAGVVALINlVKALPFAGlenlvdlani 243
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 520902619 230 FAKLLFGYGLLQLLFMLRLMPWYLRQ---PFNASFWSFSFGISALATTGLHLGQARGDGFFHHLAMPLFIF 297
Cdd:cd09321 244 FALILWGFGLWWLILAVLLTLYYLKRgnlPFSLGWWAFIFPLGAYTIATYLVAKVLNFSFLSGLGIFLYWL 314
|
|
| TDT_C4-dicarb_trans |
cd09325 |
C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) ... |
12-274 |
2.30e-09 |
|
C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; This subfamily contains bacterial C4-dicarboxylate transporters, which is part of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family. It includes Tellurite resistance protein tehA; the tehA gene encodes an integral membrane protein that has been shown to have efflux activity of quaternary ammonium compounds. TehA protein of Escherichia coli functions as a tellurite-resistance uptake permease.
Pssm-ID: 187765 Cd Length: 293 Bit Score: 57.56 E-value: 2.30e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 12 NLPAGYFGMVLGTIGMGfaWRYASTLWPVSRSIGDGLvtlAMAMWVLLsmafISRAIRFPASVLREMRHPVSSSFVSLFP 91
Cdd:cd09325 1 KIPIPIAGLALGLASLG--NLLELSYGSILRNICGLI---ALILLILL----LLKIILFPKTLKEELKNPVIASVFPTFP 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 92 ATTLLVAIGLAPWCRPLAIGLFVPGVALQLAYAAWQSggLWRGNHPR-EATTPGLYLPTVANnFISAMACGALGFSDAGL 170
Cdd:cd09325 72 MALMLLSTYLKPFFPALAQLLWLLAIILHIILIIYFT--YKRILKFNlEHVFPSWFVVYVGI-VVASVTAPAFGQPLLGQ 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 520902619 171 VFLGAGVFSWLSLEPAILQRLRSAGELPTPLRTSLGIQLAPALVACCAWLSVNGGEADTFAKLLFGYGLLQLLFMLRLMP 250
Cdd:cd09325 149 IAFWFGFVAYLILLPLVLYRLVKIKELPDAALPTIAIFAAPASLCLAGYLNSFPEPNPVLVLFLLILSQLLYFFVLLQLP 228
|
250 260
....*....|....*....|....*.
gi 520902619 251 WYLRQPFNASFWSFSF--GISALATT 274
Cdd:cd09325 229 RLLKLPFYPSFAAFTFplVISATALK 254
|
|
| |
