nucleotide 5'-monophosphate nucleosidase PpnN catalyzes the hydrolysis of the N-glycosidic bond of diverse pyrimidine and purine nucleotide 5'-monophosphates, to form ribose 5-phosphate and the corresponding free base
nucleotide 5'-monophosphate nucleosidase PpnN; PpnN (pyrimidine/purine nucleotide 5'-monophosphate nucleosidase), widely conserved in gamma proteobacteria, plays a role in purine homeostasis. It can bind the the stringent response alarmones ppGpp and pppGpp and then, because of allosteric changes, have a much higher rate of cleavage of preferred substrate GMP. PpnN was previously known in E. coli as YgdH.
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Pssm-ID: 468501 [Multi-domain] Cd Length: 450 Bit Score: 891.08 E-value: 0e+00
nucleotide 5'-monophosphate nucleosidase PpnN; PpnN (pyrimidine/purine nucleotide 5'-monophosphate nucleosidase), widely conserved in gamma proteobacteria, plays a role in purine homeostasis. It can bind the the stringent response alarmones ppGpp and pppGpp and then, because of allosteric changes, have a much higher rate of cleavage of preferred substrate GMP. PpnN was previously known in E. coli as YgdH.
Pssm-ID: 468501 [Multi-domain] Cd Length: 450 Bit Score: 891.08 E-value: 0e+00
Domain of unknown function (DUF3412); This presumed domain is functionally uncharacterized. ...
335-456
5.17e-82
Domain of unknown function (DUF3412); This presumed domain is functionally uncharacterized. This domain is found in bacteria. This domain is about 120 amino acids in length. This domain is found associated with pfam03641.
Pssm-ID: 463386 Cd Length: 121 Bit Score: 248.61 E-value: 5.17e-82
nucleotide 5'-monophosphate nucleosidase PpnN; PpnN (pyrimidine/purine nucleotide 5'-monophosphate nucleosidase), widely conserved in gamma proteobacteria, plays a role in purine homeostasis. It can bind the the stringent response alarmones ppGpp and pppGpp and then, because of allosteric changes, have a much higher rate of cleavage of preferred substrate GMP. PpnN was previously known in E. coli as YgdH.
Pssm-ID: 468501 [Multi-domain] Cd Length: 450 Bit Score: 891.08 E-value: 0e+00
Domain of unknown function (DUF3412); This presumed domain is functionally uncharacterized. ...
335-456
5.17e-82
Domain of unknown function (DUF3412); This presumed domain is functionally uncharacterized. This domain is found in bacteria. This domain is about 120 amino acids in length. This domain is found associated with pfam03641.
Pssm-ID: 463386 Cd Length: 121 Bit Score: 248.61 E-value: 5.17e-82
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidases; This is an N-terminal domain ...
9-117
2.29e-54
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidases; This is an N-terminal domain found in pyrimidine/purine nucleotide 5'-monophosphate nucleosidases (PpnN) in bacteria. PpnN catalyzes the hydrolysis of the N-glycosidic bond of diverse pyrimidine and purine nucleotide 5'-monophosphates, to form ribose 5-phosphate and the corresponding free base. It can use AMP, GMP, IMP, CMP, dTMP and UMP as substrates. It is found in association with pfam03641 and pfam11892.
Pssm-ID: 434214 Cd Length: 109 Bit Score: 176.96 E-value: 2.29e-54
Possible lysine decarboxylase; The members of this family share a highly conserved motif ...
192-329
5.52e-32
Possible lysine decarboxylase; The members of this family share a highly conserved motif PGGXGTXXE that is probably functionally important. This family includes proteins annotated as lysine decarboxylases, although the evidence for this is not clear.
Pssm-ID: 397621 Cd Length: 130 Bit Score: 118.48 E-value: 5.52e-32
SLOG cluster4 family; Family in the SLOG superfamily, observed as a standalone domain with ...
157-267
1.09e-04
SLOG cluster4 family; Family in the SLOG superfamily, observed as a standalone domain with little informative genome context, although related families in the SLOG superfamily are predicted to function in diverse conflict contexts.
Pssm-ID: 436397 Cd Length: 152 Bit Score: 42.18 E-value: 1.09e-04
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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This image shows a graphical summary of conserved domains identified on the query sequence.
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if a domain or superfamily has been annotated with functional sites (conserved features),
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click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.
To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
or click on the triangles, if present, that represent functional sites (conserved features)
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
(labeled illustration) Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance.
(labeled illustration) Four types of hits can be shown, as available,
for each region on the query sequence:
specific hits meet or exceed a domain-specific e-value threshold
(illustrated example)
and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits
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the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains
Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
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