|
Name |
Accession |
Description |
Interval |
E-value |
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
7-598 |
0e+00 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 997.34 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 7 FTSIRLKFILFFVLLILIAMQIIGVYFVRELETKLTENFKESILSRVKFLTYNVEQEFMKERVDSgqLSLELAIDKILKE 86
Cdd:NF033092 2 FRSIHFKIVLIYVLLILIAMQIIGVYFVRQLETQLLNNFKESINLRANLLSYNLEQELSKEDEDD--ETLEEDIRTILND 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 87 NTSSDINEIRVIDKNMRVIGTSDENNEDIVGQRTTDVLATRAFATEENIDQLVIDPNNG-RTWVLYVPIKVRN-NVEGLI 164
Cdd:NF033092 80 FNNNDISEIQVIDAKGTILGTSDPSNQSIVGQKTTDSDVKRALLGGKDNEKILIDPEDNnRVYVLATPIKSSNgEVVGAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 165 YLEGKIEKVFDQIQVINGVLVKGTVIASGITAILAIFVAQTITRPLSDMRSQAQAMAKGNFSRKVKVYSQDEIGQLAQTF 244
Cdd:NF033092 160 YIEASMESVYDQMNNINLIFATGTLIALVITAVLGILLARTITRPIKEMRKQALAMAKGDFSRKVKVYGNDEIGQLAEAF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 245 NYLTKKLQEEQAKTESEKRKLSSVLANMSDGVISTDRKGRIILINESAEKMLNISRDDVISKPLLAVLGIEDQYSVEDLF 324
Cdd:NF033092 240 NNLTKRLQEAQATTESERRKLDSVLSHMTDGVIATDRRGRVILINDPALEMLNVSRETVLGQSILDVLGLEEEYTLRDLL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 325 NEQGSLVLDYGTKTKPLIFRANYSTIQKETGKVNGLIVVLHDITEQEKIEMERREFVYNVSHELRTPLTTMKSYLEALSE 404
Cdd:NF033092 320 EEQDSLLLDFSTEEEPLILRANFSVIQRESGFINGLIAVLHDVTEQEKIEQERREFVANVSHELRTPLTTMRSYLEALAD 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 405 GALQDENLAPKFLKVAQNETERMIRLVNDLLQLSKIDSKDYRLDKEWVDYIRFLNRVIDRFEM-TKDESIVFVRRFPKQP 483
Cdd:NF033092 400 GAWKDPELAPRFLGVTQNETERMIRLVNDLLQLSRMDSKDYKLNKEWVNFNEFFNYIIDRFEMiLKNKNITFKREFPKRD 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 484 VYAEVDADKMTQVLDNIISNAIKYSPDGGQVTFKVVLFQNYIETRISDQGVGIPKESLEKIFERFYRVDKARSRQLGGTG 563
Cdd:NF033092 480 LWVEIDTDKITQVLDNIISNAIKYSPEGGTITFRLLETHNRIIISISDQGLGIPKKDLDKIFDRFYRVDKARSRKMGGTG 559
|
570 580 590
....*....|....*....|....*....|....*
gi 518998827 564 LGLAIAKELVEAHGGKIWATSAEGKGTTIHFTLPY 598
Cdd:NF033092 560 LGLAIAKEVVEAHGGRIWAESEEGKGTTIYFTLPY 594
|
|
| HK_VicK |
NF033093 |
cell wall metabolism sensor histidine kinase VicK; This model describes the protein VicK (or ... |
194-601 |
8.11e-132 |
|
cell wall metabolism sensor histidine kinase VicK; This model describes the protein VicK (or WalK) as found in Streptococcus pneumoniae, This protein is shorter than the WalK of Staphylococcus aureus, although apparently is functionally similar. Compare to model NF033092 (HK_WalK). VicK is a sensor histidine kinase involved in regulating cell wall metabolism. Its two component system partner is the response regulatory VicR.
Pssm-ID: 467965 [Multi-domain] Cd Length: 448 Bit Score: 393.32 E-value: 8.11e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 194 ITAILAIFVAQTITRPLSDMRSQAQAMAK------GNFSRKVKVYSQDEIGQLAQTFNYLTKKLQEEQAKTESEKRKLSS 267
Cdd:NF033093 19 LLLGFILYFILLALRNRRDNKQLRQLNQKvkdliaGDYSEVLDMQGDPELTELTNSLNDLSEVFRLTHENLEQEKNRLAS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 268 VLANMSDGVISTDRKGRIILINESAEKMLNISRDDVISKPLLAVLGIEDQYSVEDLFNEQGSLVLDYGTKTKPLI-FRAN 346
Cdd:NF033093 99 ILSYMTDGVLATNRRGQIIMINDTAQKQLNVKREEALNMNILDLLDIDDEYDLRDLITKTPELTLDSRDENGEFLsLRVR 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 347 YSTIQKETGKVNGLIVVLHDITEQEKIEMERREFVYNVSHELRTPLTTMKSYLEALSEGALqDENLAPKFLKVAQNETER 426
Cdd:NF033093 179 FALIRRESGFISGLVAVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGAL-SEPVAPSFIKVSLDETNR 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 427 MIRLVNDLLQLSKIDSKDYRLDKEWVDYIRFLNRVIDRFEMTKDESIV------FVRRFPKQPVYAEVDADKMTQVLDNI 500
Cdd:NF033093 258 MMRMISDLLSLSRIDNQTSHLDVELTNFTAFITFILNRFDQIKSQDTEtgkkyeIVRDYPITSIWVEIDTDKMTQVIDNI 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 501 ISNAIKYSPDGGQVTFKVVLFQNYIETRISDQGVGIPKESLEKIFERFYRVDKARSRQLGGTGLGLAIAKELVEAHGGKI 580
Cdd:NF033093 338 LNNAIKYSPDGGKITVSMKTTDTQLIISISDEGLGIPKKDLPLIFDRFYRVDKARSRAQGGTGLGLAIAKEIIKQHKGFI 417
|
410 420
....*....|....*....|.
gi 518998827 581 WATSAEGKGTTIHFTLPYDRD 601
Cdd:NF033093 418 WAKSEYGKGSTFTIVLPYDKD 438
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
284-601 |
7.55e-105 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 322.27 E-value: 7.55e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 284 RIILINESAEKMLNISRDDVISKPLLAVLGIEDQYSVEDLFNEQGSLVLDYGTKTKPLIFRANYSTIQKETGKVNGLIVV 363
Cdd:COG5002 72 LLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAV 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 364 LHDITEQEKIEMERREFVYNVSHELRTPLTTMKSYLEALSEGALQDENLAPKFLKVAQNETERMIRLVNDLLQLSKIDSK 443
Cdd:COG5002 152 ERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESG 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 444 DYRLDKEWVDYIRFLNRVIDRFEMT-KDESIVFVRRFPKQPVYAEVDADKMTQVLDNIISNAIKYSPDGGQVTFKVVLFQ 522
Cdd:COG5002 232 ELKLEKEPVDLAELLEEVVEELRPLaEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREED 311
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 518998827 523 NYIETRISDQGVGIPKESLEKIFERFYRVDKARSRQLGGTGLGLAIAKELVEAHGGKIWATSAEGKGTTIHFTLPYDRD 601
Cdd:COG5002 312 DQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLARE 390
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
176-603 |
2.18e-89 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 283.01 E-value: 2.18e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 176 QIQVINGVLVKGTVIASGITAI-LAIFVAQTITRPLSDMRSQAQAMAKGNFSRKVKVYSQDEIGQLAQTFNYLTKKLQEE 254
Cdd:COG5000 2 GLQILFLLLLLLIALLLLLLALwLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKEQ 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 255 QAKTESEKRKLSSVLANMSDGVISTDRKGRIILINESAEKMLNISRDDVISKPLLAVLGIEDQYS-VEDLFNEQGSLVLD 333
Cdd:COG5000 82 REELEERRRYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGKPLEELLPELDLAElLREALERGWQEEIE 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 334 YgTKTKPLIFRANYSTIQketgkVNGLIVVLHDITEQekIEMER----REFVYNVSHELRTPLTTMKSYLE----ALSEG 405
Cdd:COG5000 162 L-TRDGRRTLLVRASPLR-----DDGYVIVFDDITEL--LRAERlaawGELARRIAHEIKNPLTPIQLSAErlrrKLADK 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 406 ALQDENLAPKFLKVAQNETERMIRLVNDLLQLSKIDskdyRLDKEWVDYIRFLNRVIDRFEMT-KDESIVFVRRFPKQPV 484
Cdd:COG5000 234 LEEDREDLERALDTIIRQVDRLKRIVDEFLDFARLP----EPQLEPVDLNELLREVLALYEPAlKEKDIRLELDLDPDLP 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 485 YAEVDADKMTQVLDNIISNAIKYSPDGGQVTFKVVLFQNYIETRISDQGVGIPKESLEKIFERFYrvdkarSRQLGGTGL 564
Cdd:COG5000 310 EVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFF------TTKPKGTGL 383
|
410 420 430
....*....|....*....|....*....|....*....
gi 518998827 565 GLAIAKELVEAHGGKIWATSAEGKGTTIHFTLPYDRDQK 603
Cdd:COG5000 384 GLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAEEAE 422
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
369-597 |
6.54e-82 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 257.14 E-value: 6.54e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 369 EQEKIEMERREFVYNVSHELRTPLTTMKSYLEALSEGALQDENLAPKFLKVAQNETERMIRLVNDLLQLSKIDSKDYRLD 448
Cdd:COG2205 8 ELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLESGKLSLE 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 449 KEWVDYIRFLNRVIDRFEMT-KDESIVFVRRFPKQPVYAEVDADKMTQVLDNIISNAIKYSPDGGQVTFKVVLFQNYIET 527
Cdd:COG2205 88 LEPVDLAELLEEAVEELRPLaEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREGDGVRI 167
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 528 RISDQGVGIPKESLEKIFERFYRVDKARSRqlGGTGLGLAIAKELVEAHGGKIWATSAEGKGTTIHFTLP 597
Cdd:COG2205 168 SVSDNGPGIPEEELERIFERFYRGDNSRGE--GGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLP 235
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
268-597 |
6.85e-73 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 237.11 E-value: 6.85e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 268 VLANMSDGVISTDRKGRIILINESAEKMLNISRDDVISKPLLAVLGIEDQYSVEDLFNEQGSLVLDYGTKTKPLIFRANY 347
Cdd:COG0642 1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 348 STIQKETGKVNGLIVVLHDITEQEKIEMERREFVYNVSHELRTPLTTMKSYLEALSEGALQDENlapKFLKVAQNETERM 427
Cdd:COG0642 81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQR---EYLETILRSADRL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 428 IRLVNDLLQLSKIDSKDYRLDKEWVDYIRFLNRVIDRFE-MTKDESIVFVRRFPKQPVYAEVDADKMTQVLDNIISNAIK 506
Cdd:COG0642 158 LRLINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRpLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIK 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 507 YSPDGGQVTFKVVLFQNYIETRISDQGVGIPKESLEKIFERFYRVDKARSRqlGGTGLGLAIAKELVEAHGGKIWATSAE 586
Cdd:COG0642 238 YTPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRG--GGTGLGLAIVKRIVELHGGTIEVESEP 315
|
330
....*....|.
gi 518998827 587 GKGTTIHFTLP 597
Cdd:COG0642 316 GKGTTFTVTLP 326
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
259-596 |
1.55e-70 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 230.94 E-value: 1.55e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 259 ESEKRKLSSVLANMSDGVISTDRKGRIILINESAEKMLNISRDDVISKPLLAVLGIED--QYSVEDLFNEqgSLVLDYGT 336
Cdd:TIGR02966 2 SALLSRFRAAAQALPDAVVVLDEEGQIEWCNPAAERLLGLRWPDDLGQRITNLIRHPEfvEYLAAGRFSE--PLELPSPI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 337 -KTKPLIFR-ANYStiqketgkVNGLIVVLHDITEQEKIEMERREFVYNVSHELRTPLTTMKSYLEALSEGALQDENLAP 414
Cdd:TIGR02966 80 nSERVLEIRiAPYG--------EEQKLLVARDVTRLRRLEQMRRDFVANVSHELRTPLTVLRGYLETLADGPDEDPEEWN 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 415 KFLKVAQNETERMIRLVNDLLQLSKIDSKDYRLDKEWVDYIRFLNRVIDRFE----------MTKDESIVFVRRFPKQpv 484
Cdd:TIGR02966 152 RALEIMLEQSQRMQSLVEDLLTLSRLESAASPLEDEPVDMPALLDHLRDEAEalsqgknhqiTFEIDGGVDVLGDEDE-- 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 485 yaevdadkMTQVLDNIISNAIKYSPDGGQVTFKVVLFQNYIETRISDQGVGIPKESLEKIFERFYRVDKARSRQLGGTGL 564
Cdd:TIGR02966 230 --------LRSAFSNLVSNAIKYTPEGGTITVRWRRDGGGAEFSVTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGL 301
|
330 340 350
....*....|....*....|....*....|..
gi 518998827 565 GLAIAKELVEAHGGKIWATSAEGKGTTIHFTL 596
Cdd:TIGR02966 302 GLAIVKHVLSRHHARLEIESELGKGSTFSFIF 333
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
259-597 |
3.52e-63 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 212.40 E-value: 3.52e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 259 ESEKRKLSSVLANMSDGVISTDRKGRIILINESAEKMLNISRDDVISKPLLAVLGIEDQYS--VEDLFNEQGSLV---LD 333
Cdd:COG3852 3 RESEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFPEDSPLRelLERALAEGQPVTereVT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 334 YGTKT-KPLIFRANYSTIQKETGKVnGLIVVLHDITEQEKIEMERR---------EFVYNVSHELRTPLTTMKSYLEALS 403
Cdd:COG3852 83 LRRKDgEERPVDVSVSPLRDAEGEG-GVLLVLRDITERKRLERELRraeklaavgELAAGLAHEIRNPLTGIRGAAQLLE 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 404 EgALQDENLApKFLKVAQNETERMIRLVNDLLQLSKIDskdyRLDKEWVDYIRFLNRVIDRFEMTKDESIVFVRRFPKQP 483
Cdd:COG3852 162 R-ELPDDELR-EYTQLIIEEADRLNNLVDRLLSFSRPR----PPEREPVNLHEVLERVLELLRAEAPKNIRIVRDYDPSL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 484 VYAEVDADKMTQVLDNIISNAIKYSPDGGQVTFKV----------VLFQNYIETRISDQGVGIPKESLEKIFERFYrvdk 553
Cdd:COG3852 236 PEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTrverqvtlggLRPRLYVRIEVIDNGPGIPEEILDRIFEPFF---- 311
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 518998827 554 arSRQLGGTGLGLAIAKELVEAHGGKIWATSAEGKGTTIHFTLP 597
Cdd:COG3852 312 --TTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLP 353
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
9-604 |
3.39e-59 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 208.28 E-value: 3.39e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 9 SIRLKFILFFVLLILIAMQIIGVYFVRELETKLTENfKESILSRVkflTYNVEQEF------MKERVDSGQLS------- 75
Cdd:PRK11360 5 SFRNQLILLVILLVIVPTLLIGYILETEGRSAVLSE-KEKKLSAV---VNLLDQALggrfdlYLASQGVADLPreekira 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 76 ----LELAIDKILKENtsSDInEIRVIDKNMRVIGTSDENNE--DIVGQRTT------DVLATRAFATEenidqlVIDPN 143
Cdd:PRK11360 81 lnaeLAPVTENITHAY--PGI-GAGYYSKELDAIITYGPSALyqENVGVRIKadhpgrEVMRTNTPLVE------SGGQV 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 144 NGRTWVLYVPIKVRNNVEGLIYLEGKIEKVFDQIQVINGVLVkgTVIASGItaILAIFVAQTITRPLSDMRSQaqaMAKG 223
Cdd:PRK11360 152 RGGILNSMIPIERNGEVIGYIWANELTEDIRRQAWKMDRRIY--AVLAAGL--VIGLLLIFLLSRRFSANVDI---IKDG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 224 nfsrkVKVYSQD----------EIGQLAQTFNYLTKKLQEEQAKTESekrklssVLANMSDGVISTDRKGRIILINESAE 293
Cdd:PRK11360 225 -----LSTLENDlstrlpplpgELGEISQAINNLAQALRETRSLNEL-------ILESIADGVIAIDRQGKITTMNPAAE 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 294 KMLNISRDDVISKPLLAVLgIEDQYSVEDLFN--EQGSLVLDY----GTKTKPLIFRANYSTIQKETGKVNGLIVVLHDI 367
Cdd:PRK11360 293 VITGLQRHELVGKPYSELF-PPNTPFASPLLDtlEHGTEHVDLeisfPGRDRTIELSVSTSLLHNTHGEMIGALVIFSDL 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 368 TEQEkiEMERR-----------EFVYNVSHELRTPLTTMKSYLEALSEGALQDENlaPKFLKVAQNETERMIRLVNDLLQ 436
Cdd:PRK11360 372 TERK--RLQRRvarqerlaalgELVAGVAHEIRNPLTAIRGYVQIWRQQTSDPPS--QEYLSVVLREVDRLNKVIDQLLE 447
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 437 LSK-----IDSKDyrldkewvdyirfLNRVIDR----FEMT-KDESIVFVRRFPKQPVYAEVDADKMTQVLDNIISNAIK 506
Cdd:PRK11360 448 FSRpresqWQPVS-------------LNALVEEvlqlFQTAgVQARVDFETELDNELPPIWADPELLKQVLLNILINAVQ 514
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 507 YSPDGGQVTFKVvlfQNYIETR----ISDQGVGIPKESLEKIFERFYRVdKARsrqlgGTGLGLAIAKELVEAHGGKIWA 582
Cdd:PRK11360 515 AISARGKIRIRT---WQYSDGQvavsIEDNGCGIDPELLKKIFDPFFTT-KAK-----GTGLGLALSQRIINAHGGDIEV 585
|
650 660
....*....|....*....|..
gi 518998827 583 TSAEGKGTTIHFTLPYDRDQKD 604
Cdd:PRK11360 586 ESEPGVGTTFTLYLPINPQGNQ 607
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
229-603 |
1.41e-58 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 203.67 E-value: 1.41e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 229 VKVYSQDEIGQLAQTFNYLTKKLQEEQAKtESEKrKLSSVLANMSDGVISTDRKGRIILINESAEKMLNISRDDVISKPL 308
Cdd:COG5809 109 IFDQNGDIEGMLAISRDITERKRMEEALR-ESEE-KFRLIFNHSPDGIIVTDLDGRIIYANPAACKLLGISIEELIGKSI 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 309 LAVLGIEDQYSVEDLFNE----QGSLVLDYGTKTK---PLIFRANYSTIqKETGKVNGLIVVLHDITEQEKIEMERR--- 378
Cdd:COG5809 187 LELIHSDDQENVAAFISQllkdGGIAQGEVRFWTKdgrWRLLEASGAPI-KKNGEVDGIVIIFRDITERKKLEELLRkse 265
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 379 ------EFVYNVSHELRTPLTTMKSYLEALSEGALQDENlapKFLKVAQNETERMIRLVNDLLQLSKIDSKDYRLdkewV 452
Cdd:COG5809 266 klsvvgELAAGIAHEIRNPLTSLKGFIQLLKDTIDEEQK---TYLDIMLSELDRIESIISEFLVLAKPQAIKYEP----K 338
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 453 DYIRFLNRVIDRFEMTKDESIVFVRRFPKQ---PVYAEVDADKmtQVLDNIISNAIKYSPDGGQVTFKV-VLFQNYIETR 528
Cdd:COG5809 339 DLNTLIEEVIPLLQPQALLKNVQIELELEDdipDILGDENQLK--QVFINLLKNAIEAMPEGGNITIETkAEDDDKVVIS 416
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 518998827 529 ISDQGVGIPKESLEKIFERFYrvdkarSRQLGGTGLGLAIAKELVEAHGGKIWATSAEGKGTTIHFTLPYDRDQK 603
Cdd:COG5809 417 VTDEGCGIPEERLKKLGEPFY------TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIKLSEQ 485
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
274-597 |
1.44e-51 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 183.29 E-value: 1.44e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 274 DGVISTDRKGRIILINESAEKMLNISRDDVISKPLLAVLGIED--QYSVEDLFNEQGSLVLDYGtktKPLIFR-ANYSTI 350
Cdd:PRK11006 109 DAVVLTTEEGNIFWCNGLAQQLLGFRWPEDNGQNILNLLRYPEftQYLKTRDFSRPLTLVLNNG---RHLEIRvMPYTEG 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 351 QketgkvngLIVVLHDITEQEKIEMERREFVYNVSHELRTPLTTMKSYLEALSEGALqDENLAPKFLKVAQNETERMIRL 430
Cdd:PRK11006 186 Q--------LLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQDQPL-EGALREKALHTMREQTQRMEGL 256
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 431 VNDLLQLSKIDSKDYRLDKEWVDYIRFLnRVIDRFEMT---KDESIVFvRRFPKQPVYAevDADKMTQVLDNIISNAIKY 507
Cdd:PRK11006 257 VKQLLTLSKIEAAPTIDLNEKVDVPMML-RVLEREAQTlsqGKHTITF-EVDNSLKVFG--NEDQLRSAISNLVYNAVNH 332
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 508 SPDGGQVTFKVVLFQNYIETRISDQGVGIPKESLEKIFERFYRVDKARSRQLGGTGLGLAIAKELVEAHGGKIWATSAEG 587
Cdd:PRK11006 333 TPEGTHITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVG 412
|
330
....*....|
gi 518998827 588 KGTTIHFTLP 597
Cdd:PRK11006 413 KGTRFSFVLP 422
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
369-597 |
1.83e-50 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 182.29 E-value: 1.83e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 369 EQEKIEMERREFVYNVSHELRTPLTTMKSYLEALSE---GALQDEnlAPKFLKVAQNETERMIRLVNDLLQLSKIDSKDy 445
Cdd:COG4251 274 ELERSNEELEQFAYVASHDLREPLRKISGFSQLLEEdygDKLDEE--GREYLERIRDAAERMQALIDDLLAYSRVGRQE- 350
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 446 rLDKEWVDYIRFLNRVIDRFEMTKDESIVFVRRFPKQPVYAevDADKMTQVLDNIISNAIKYSPDG--GQVTFKVVLFQN 523
Cdd:COG4251 351 -LEFEPVDLNELLEEVLEDLEPRIEERGAEIEVGPLPTVRG--DPTLLRQVFQNLISNAIKYSRPGepPRIEIGAEREGG 427
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 518998827 524 YIETRISDQGVGIPKESLEKIFERFYRVDkaRSRQLGGTGLGLAIAKELVEAHGGKIWATSAEGKGTTIHFTLP 597
Cdd:COG4251 428 EWVFSVRDNGIGIDPEYAEKIFEIFQRLH--SRDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLP 499
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
226-597 |
2.56e-48 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 176.08 E-value: 2.56e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 226 SRKVKVYSQDEIGQLAQTFNYLTKKLQEEQAKtESEKRkLSSVLANMSDGVISTDRKGRIILINESAEKMLNISRDDVIS 305
Cdd:COG5805 122 VKLFPIYNQNGQAAILALRDITKKKKIEEILQ-EQEER-LQTLIENSPDLICVIDTDGRILFINESIERLFGAPREELIG 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 306 KPLLAVLGIEDQ-------YSVEDLFNEQGSLVLDYGTKTKPLIFRANYSTIQKETGKVNGLIVVLHDITEQEKIEMERR 378
Cdd:COG5805 200 KNLLELLHPCDKeefkeriESITEVWQEFIIEREIITKDGRIRYFEAVIVPLIDTDGSVKGILVILRDITEKKEAEELMA 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 379 ---------EFVYNVSHELRTPLTTMKSYLEALSEGALQDEnlapKFLKVAQNETERMIRLVNDLLQLSKIDSkdyrLDK 449
Cdd:COG5805 280 rseklsiagQLAAGIAHEIRNPLTSIKGFLQLLQPGIEDKE----EYFDIMLSELDRIESIISEFLALAKPQA----VNK 351
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 450 EWVDYIRFLNRVIDRFEMT---KDESIVFVRRFPKQPVYAevDADKMTQVLDNIISNAIKYSPDGGQVTFKVVLFQNYIE 526
Cdd:COG5805 352 EKENINELIQDVVTLLETEailHNIQIRLELLDEDPFIYC--DENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVI 429
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 518998827 527 TRISDQGVGIPKESLEKIFERFYRVDKArsrqlgGTGLGLAIAKELVEAHGGKIWATSAEGKGTTIHFTLP 597
Cdd:COG5805 430 IRVIDEGIGIPEERLKKLGEPFFTTKEK------GTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
371-601 |
5.64e-44 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 163.27 E-value: 5.64e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 371 EKIEMERREFVYNVSHELRTPLTTMKSYLEALSEGALQdenLAPKFLKVAQNETERMIRLVNDLLQLSKID--SKDYRld 448
Cdd:PRK10549 234 EKNEQMRRDFMADISHELRTPLAVLRGELEAIQDGVRK---FTPESVASLQAEVGTLTKLVDDLHQLSLSDegALAYR-- 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 449 KEWVDYIRFLNRVIDRF-EMTKDESIVFVRRFPKQ-PVYAevDADKMTQVLDNIISNAIKYSPDGGQVTFKVVLFQNYIE 526
Cdd:PRK10549 309 KTPVDLVPLLEVAGGAFrERFASRGLTLQLSLPDSaTVFG--DPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLR 386
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 518998827 527 TRISDQGVGIPKESLEKIFERFYRVDKARSRQLGGTGLGLAIAKELVEAHGGKIWATSAEGKGTTIHFTLPYDRD 601
Cdd:PRK10549 387 LTFADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERD 461
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
365-597 |
3.54e-42 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 159.04 E-value: 3.54e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 365 HDITEQEKIEMERREFVYNVSHELRTPLTT--MKSYLEALSEGALqdENLAPKFLKVAQNETERMIRLVNDLLQLSKIDS 442
Cdd:NF040691 259 RQIRQLEELSRLQQRFVSDVSHELRTPLTTirMAADVIHDSRDDF--DPATARSAELLHTELDRFESLLSDLLEISRFDA 336
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 443 KDYRLDKEWVDYIRFLNRVIDRFEMTKDESIVFVR-RFPKQPVYAEVDADKMTQVLDNIISNAIKYSpDGGQVtfKVVLF 521
Cdd:NF040691 337 GAAELDVEPVDLRPLVRRVVDALRQLAERAGVELRvDAPGTPVVAEVDPRRVERVLRNLVVNAIEHG-EGKPV--VVTVA 413
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 518998827 522 QNY--IETRISDQGVGIPKESLEKIFERFYRVDKARSRQLGGTGLGLAIAKELVEAHGGKIWATSAEGKGTTIHFTLP 597
Cdd:NF040691 414 QDDtaVAVTVRDHGVGLKPGEVALVFDRFWRADPARARTTGGTGLGLAIALEDARLHGGWLEAWGRPGQGSQFRLTLP 491
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
360-597 |
5.64e-42 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 155.34 E-value: 5.64e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 360 LIVVLHDITEQEKIEMERR----------------EFVYNVSHELRTPLTTMKSYLEALSEGALQDENL--APKFLKVAQ 421
Cdd:COG4191 109 LEELERDITELERAEEELRelqeqlvqseklaalgELAAGIAHEINNPLAAILGNAELLRRRLEDEPDPeeLREALERIL 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 422 NETERMIRLVNDLLQLSKIDSkdyrLDKEWVDyirfLNRVIDRFEM-----TKDESIVFVRRFPKQPVYAEVDADKMTQV 496
Cdd:COG4191 189 EGAERAAEIVRSLRAFSRRDE----EEREPVD----LNELIDEALEllrprLKARGIEVELDLPPDLPPVLGDPGQLEQV 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 497 LDNIISNAIKYSPDG--GQVTFKVVLFQNYIETRISDQGVGIPKESLEKIFERFY---RVDKarsrqlgGTGLGLAIAKE 571
Cdd:COG4191 261 LLNLLINAIDAMEEGegGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFttkPVGK-------GTGLGLSISYG 333
|
250 260
....*....|....*....|....*.
gi 518998827 572 LVEAHGGKIWATSAEGKGTTIHFTLP 597
Cdd:COG4191 334 IVEKHGGRIEVESEPGGGTTFTITLP 359
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
380-596 |
2.73e-41 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 155.62 E-value: 2.73e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 380 FVYNVSHELRTPLTTMKSYLE-ALSEGALQDENLApkFLKVAQNETERMIRLVNDLLQLSKIDSKDYRLDKEWVDYIRFL 458
Cdd:TIGR01386 244 FSADLAHELRTPLTNLLGQTQvALSQPRTGEEYRE--VLESNLEELERLSRMVSDMLFLARADNGQLALERVRLDLAAEL 321
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 459 NRVIDRFEMTKDESIVFVRRFPKqpVYAEVDADKMTQVLDNIISNAIKYSPDGGQVTFKVVLFQNYIETRISDQGVGIPK 538
Cdd:TIGR01386 322 AKVAEYFEPLAEERGVRIRVEGE--GLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGPGIPP 399
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 518998827 539 ESLEKIFERFYRVDKARSRQLGGTGLGLAIAKELVEAHGGKIWATSAEGKgttIHFTL 596
Cdd:TIGR01386 400 EHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDGK---TRFIL 454
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
489-598 |
3.57e-40 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 142.02 E-value: 3.57e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 489 DADKMTQVLDNIISNAIKYSPDGGQVTFKVVLFQNYIETRISDQGVGIPKESLEKIFERFYRVDKaRSRQLGGTGLGLAI 568
Cdd:smart00387 2 DPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLSI 80
|
90 100 110
....*....|....*....|....*....|
gi 518998827 569 AKELVEAHGGKIWATSAEGKGTTIHFTLPY 598
Cdd:smart00387 81 VKKLVELHGGEISVESEPGGGTTFTITLPL 110
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
493-596 |
1.31e-39 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 140.05 E-value: 1.31e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 493 MTQVLDNIISNAIKYSPDGGQVTFKVVLFQNYIETRISDQGVGIPKESLEKIFERFYRVDKarSRQLGGTGLGLAIAKEL 572
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDK--SREGGGTGLGLAIVRRI 78
|
90 100
....*....|....*....|....
gi 518998827 573 VEAHGGKIWATSAEGKGTTIHFTL 596
Cdd:cd00075 79 VEAHGGRITVESEPGGGTTFTVTL 102
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
384-597 |
8.25e-39 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 147.02 E-value: 8.25e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 384 VSHELRTPLTTMKSYLEALSEGALQDENLAP-----KFLKVAQNETERMIRLVNDLLQLSKIDSKDYRLDKEWVDYIRFL 458
Cdd:PRK09303 158 LAHDLRTPLTAASLALETLELGQIDEDTELKpalieQLQDQARRQLEEIERLITDLLEVGRTRWEALRFNPQKLDLGSLC 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 459 NRVIDRFEMT-KDESIVFVRRFPKQ--PVYAevDADKMTQVLDNIISNAIKYSPDGGQVTFKVVLFQN-YIETRISDQGV 534
Cdd:PRK09303 238 QEVILELEKRwLAKSLEIQTDIPSDlpSVYA--DQERIRQVLLNLLDNAIKYTPEGGTITLSMLHRTTqKVQVSICDTGP 315
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 518998827 535 GIPKESLEKIFERFYRVDkaRSRQLGGTGLGLAIAKELVEAHGGKIWATSAEGKGTTIHFTLP 597
Cdd:PRK09303 316 GIPEEEQERIFEDRVRLP--RDEGTEGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTLP 376
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
495-597 |
1.76e-35 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 129.15 E-value: 1.76e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 495 QVLDNIISNAIKYSPDGgQVTFKVVLF-----QNYIETRISDQGVGIPKESLEKIFERFYRVDKARSRQLGGTGLGLAIA 569
Cdd:cd16922 3 QILLNLLGNAIKFTEEG-EVTLRVSLEeeeedGVQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAIS 81
|
90 100
....*....|....*....|....*...
gi 518998827 570 KELVEAHGGKIWATSAEGKGTTIHFTLP 597
Cdd:cd16922 82 KKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
489-600 |
2.98e-34 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 125.56 E-value: 2.98e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 489 DADKMTQVLDNIISNAIKYSPDGGQVTFKVVlFQNYIETRISDQGVGIPKESLEKIFERFYRVDKarsRQLGGTGLGLAI 568
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAGEITVTLS-EGGELTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGLSI 77
|
90 100 110
....*....|....*....|....*....|..
gi 518998827 569 AKELVEAHGGKIWATSAEGKGTTIHFTLPYDR 600
Cdd:pfam02518 78 VRKLVELLGGTITVESEPGGGTTVTLTLPLAQ 109
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
371-597 |
5.44e-34 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 134.95 E-value: 5.44e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 371 EKIEMERREFVYNVSHELRTPLTTMKSYLEALSEGALQdenLAPKFLKVAQNETERMIRLVNDLLQLSKIDSKDYRLDKE 450
Cdd:NF012163 234 EKNEQMRRDFMADISHELRTPLAVLRAELEAIQDGIRK---FTPESLDSLQAEVGTLTKLVDDLHDLSMSDEGALAYQKA 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 451 WVDYI------------RFLNRVIDRFEMTKDESIVFvrrfpkqpvyaeVDADKMTQVLDNIISNAIKYSPDGGQVtfkv 518
Cdd:NF012163 311 SVDLVplleveggafreRFASAGLELEVSLPDSSLVF------------GDRDRLMQLFNNLLENSLRYTDSGGSL---- 374
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 519 vlfqnYIETRISDQGV---------GIPKESLEKIFERFYRVDKARSRQLGGTGLGLAIAKELVEAHGGKIWATSAEGKG 589
Cdd:NF012163 375 -----HISASQRPKEVtltvadsapGVSDEQLARLFERFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTLHAAHSPLGG 449
|
....*...
gi 518998827 590 TTIHFTLP 597
Cdd:NF012163 450 LRIVVTLP 457
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
371-597 |
2.25e-33 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 133.36 E-value: 2.25e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 371 EKIE---MERREFVYNVSHELRTPLTTMKSYLE-ALSEGALQDEnlAPKFLKVAQNETERMIRLVNDLLQLSKIDSKDYR 446
Cdd:PRK09835 253 ERIEdvfTRQSNFSADIAHEIRTPITNLITQTEiALSQSRSQKE--LEDVLYSNLEELTRMAKMVSDMLFLAQADNNQLI 330
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 447 LDKEWVDYIRFLNRVIDRFEMTKDESIVFVRrFPKQPVYAEVDADKMTQVLDNIISNAIKYSPDGGQVTFKVVLFQNYIE 526
Cdd:PRK09835 331 PEKKMLDLADEVGKVFDFFEAWAEERGVELR-FVGDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQ 409
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 518998827 527 TRISDQGVGIPKESLEKIFERFYRVDKARSRQLGGTGLGLAIAKELVEAHGGKIWATSaEGKGTTIHFTLP 597
Cdd:PRK09835 410 LVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTS-DARGTRFVISLP 479
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
368-597 |
7.24e-32 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 131.70 E-value: 7.24e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 368 TEQEKIEMERrEFVYN-----VSHELRTPLTTMKSYLEAL-----SEGAlqdeNLAPKFLKVAQnETERMIRLVNDLLQL 437
Cdd:PRK10490 651 EEQARLASER-EQLRNallaaLSHDLRTPLTVLFGQAEILtldlaSEGS----PHARQASEIRQ-QVLNTTRLVNNLLDM 724
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 438 SKIDSKDYRLDKEWVDY-------IRFLNRVIDRFEMTKDesivfvrrFPKQPVYAEVDADKMTQVLDNIISNAIKYSPD 510
Cdd:PRK10490 725 ARIQSGGFNLRKEWLTLeevvgsaLQMLEPGLSGHPINLS--------LPEPLTLIHVDGPLFERVLINLLENAVKYAGA 796
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 511 GGQVTFKVVLFQNYIETRISDQGVGIPKESLEKIFERFYRVDKARSrqLGGTGLGLAIAKELVEAHGGKIWATSAEGKGT 590
Cdd:PRK10490 797 QAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESA--IPGVGLGLAICRAIVEVHGGTIWAENRPEGGA 874
|
....*..
gi 518998827 591 TIHFTLP 597
Cdd:PRK10490 875 CFRVTLP 881
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
381-594 |
1.14e-30 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 123.18 E-value: 1.14e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 381 VYN--VSHELRTPLTTMKSYLEALSEGALQ-DENLAPKFLkvaqNETERMIRLVNDLLQLSKIDSKDYRLDKEWVDYIRF 457
Cdd:NF012226 140 VWNaaIAHELRTPITILQGRLQGILDGVFEpDPALFKSLL----NQVEGLSHLVEDLRTLSLVENQQLRLNYESVDLKDS 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 458 LNRVI----DRFEMTKdesIVFVRRFPKQPVYaeVDADKMTQVLDNIISNAIKYSpDGGQVTFKVVLFQNYIETRISDQG 533
Cdd:NF012226 216 IEKVLkmfeDRLEQAQ---LTIVLNLTATPVF--CDRRRIEQVLIALIDNAIRYA-NAGKLKISSSVIQDDWILQIEDEG 289
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518998827 534 VGIPKESLEKIFERFYRVDKARSRQLGGTGLGLAIAKELVEAHGGKI-WATSAEGKGTTIHF 594
Cdd:NF012226 290 PGIAEEYQQDLFNPFFRLEQSRNKEFGGTGLGLAVVHAIVIAHKGSIeYSNSQGNSVFTIKL 351
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
495-597 |
1.26e-30 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 115.50 E-value: 1.26e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 495 QVLDNIISNAIKYSP---------DGGQVTFkvvlfqnyietRISDQGVGIPKESLEKIFERFYRVDKARSRQLGGTGLG 565
Cdd:cd16949 3 RALENVLRNALRYSPskilldisqDGDQWTI-----------TITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLG 71
|
90 100 110
....*....|....*....|....*....|..
gi 518998827 566 LAIAKELVEAHGGKIWATSAEGKGTTIHFTLP 597
Cdd:cd16949 72 LAIAERAIEQHGGKIKASNRKPGGLRVRIWLP 103
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
369-603 |
8.82e-30 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 125.28 E-value: 8.82e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 369 EQEKIEMERREFVYNVSHELRTPLTTMKSYLEALSEGALQDENlaPKFLKVAQNETERMIRLVNDLLQLSKIDSKDYRLD 448
Cdd:TIGR02956 456 EAEEANRAKSAFLATMSHEIRTPLNGILGTLELLGDTGLTSQQ--QQYLQVINRSGESLLDILNDILDYSKIEAGHLSIS 533
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 449 KEWVDYIRFLNRVIDRFEM-TKDESIVFVRRFPKQ-PVYAEVDADKMTQVLDNIISNAIKYSpDGGQVTFKVVLF-QNYI 525
Cdd:TIGR02956 534 PRPFDLNALLDDVHHLMVSrAQLKGIQLRLNIPEQlPNWWQGDGPRIRQVLINLVGNAIKFT-DRGSVVLRVSLNdDSSL 612
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 518998827 526 ETRISDQGVGIPKESLEKIFERFYRVDKARSrqLGGTGLGLAIAKELVEAHGGKIWATSAEGKGTTIHFTLPYDRDQK 603
Cdd:TIGR02956 613 LFEVEDTGCGIAEEEQATLFDAFTQADGRRR--SGGTGLGLAISQRLVEAMDGELGVESELGVGSCFWFTLPLTRGKP 688
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
489-597 |
4.69e-29 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 111.04 E-value: 4.69e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 489 DADKMTQVLDNIISNAIKYSPDGGQVTFKVVLFQ-NYIETRISDQGVGIPKESLEKIFERFYRVDKARSRQLGGTGLGLA 567
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFRlNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80
|
90 100 110
....*....|....*....|....*....|
gi 518998827 568 IAKELVEAHGGKIWATSAEGKGTTIHFTLP 597
Cdd:cd16925 81 IVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
381-597 |
7.52e-29 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 120.04 E-value: 7.52e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 381 VYNVSHELRTPLTTMKsyleaLSEGALQDENLAPKFLKVAQNETERMIRLVNDLLQLSKIDSKDYrLDKEWVDYIRFLNR 460
Cdd:PRK09470 247 LSDISHELRTPLTRLQ-----LATALLRRRQGESKELERIETEAQRLDSMINDLLVLSRNQQKNH-LERETFKANSLWSE 320
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 461 VID--RFE---MTKDesiVFVRRFPKQ-PVYAEVDAdkMTQVLDNIISNAIKYSPDGGQVTFKVVlfQNYIETRISDQGV 534
Cdd:PRK09470 321 VLEdaKFEaeqMGKS---LTVSAPPGPwPINGNPNA--LASALENIVRNALRYSHTKIEVAFSVD--KDGLTITVDDDGP 393
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 518998827 535 GIPKESLEKIFERFYRVDKARSRQLGGTGLGLAIAKELVEAHGGKIWATSAEGKGTTIHFTLP 597
Cdd:PRK09470 394 GVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLP 456
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
355-597 |
8.57e-29 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 121.97 E-value: 8.57e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 355 GKVNGLIVVLHDITE----QEKIEMERRE---FVYNVSHELRTPLTTMKSYLEALSEGALQDENLapKFLKVAQNETERM 427
Cdd:PRK11091 254 GKRHGLMGFGRDITErkryQDALEKASRDkttFISTISHELRTPLNGIVGLSRILLDTELTAEQR--KYLKTIHVSAITL 331
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 428 IRLVNDLLQLSKIDSKDYRLDKEWVDYIRFLNRVID-RFEMTKDESIVFV-RRFPKQPVYAEVDADKMTQVLDNIISNAI 505
Cdd:PRK11091 332 GNIFNDIIDMDKMERRKLQLDNQPIDFTDFLADLENlSGLQAEQKGLRFDlEPLLPLPHKVITDGTRLRQILWNLISNAV 411
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 506 KYSPDGGqVTFKVVLFQNYIET-RISDQGVGIPKESLEKIFERFYRV-DKARSRQLGGTGLGLAIAKELVEAHGGKIWAT 583
Cdd:PRK11091 412 KFTQQGG-VTVRVRYEEGDMLTfEVEDSGIGIPEDELDKIFAMYYQVkDSHGGKPATGTGIGLAVSKRLAQAMGGDITVT 490
|
250
....*....|....
gi 518998827 584 SAEGKGTTIHFTLP 597
Cdd:PRK11091 491 SEEGKGSCFTLTIH 504
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
380-597 |
2.04e-28 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 118.79 E-value: 2.04e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 380 FVYNVSHELRTPLTTMKSYLEALSEGALQDEnlAPKFLKVAQNETERMIRLVNDLLQLSKIDSKDYRLDKEWVDYIRFLN 459
Cdd:PRK11100 259 YVQTLTHELKSPLAAIRGAAELLQEDPPPED--RARFTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLE 336
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 460 RVIDRFEMTKDESIVFVRRFPkQPVYAEVDADKMTQVLDNIISNAIKYSPDGGQVTFKVVLFQNYIETRISDQGVGIPKE 539
Cdd:PRK11100 337 ELVEAREAQAAAKGITLRLRP-DDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPDY 415
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 518998827 540 SLEKIFERFY---RVDKARSrqlgGTGLGLAIAKELVEAHGGKIWATSAEGKGTTIHFTLP 597
Cdd:PRK11100 416 ALPRIFERFYslpRPANGRK----STGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLP 472
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
374-605 |
1.28e-27 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 116.04 E-value: 1.28e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 374 EMERRE-------FVYNVSHELRTPLTTMKSYLEALSEGA---LQDENLApkflKVAQNETERMIRLVNDLLQLSKidsk 443
Cdd:PRK10364 227 EMKRKEklvalghLAAGVAHEIRNPLSSIKGLAKYFAERApagGEAHQLA----QVMAKEADRLNRVVSELLELVK---- 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 444 DYRLDKEWVDYIRFLNRVIDRFEMTKDESIVFVRRFPKQPV-YAEVDADKMTQVLDNIISNAIKYSPDGGQVTFKVVLFQ 522
Cdd:PRK10364 299 PTHLALQAVDLNDLINHSLQLVSQDANSREIQLRFTANDTLpEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESG 378
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 523 NYIETRISDQGVGIPKESLEKIFERFYrVDKARsrqlgGTGLGLAIAKELVEAHGGKIWATSAEGKGTTIHFTLPYDRDQ 602
Cdd:PRK10364 379 AGVKISVTDSGKGIAADQLEAIFTPYF-TTKAE-----GTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVNITR 452
|
...
gi 518998827 603 KDD 605
Cdd:PRK10364 453 RDP 455
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
499-597 |
4.84e-26 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 102.67 E-value: 4.84e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 499 NIISNAIKYSPDGGQVTFKVVLFQNYIETRISDQGVGIPKESLEKIFERFYRVDKARSRQLGGTGLGLAIAKELVEAHGG 578
Cdd:cd16952 7 NLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVMSRHDA 86
|
90
....*....|....*....
gi 518998827 579 KIWATSAEGKGTTIHFTLP 597
Cdd:cd16952 87 RLLIASELGKGSRFTCLFP 105
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
489-597 |
9.30e-26 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 101.77 E-value: 9.30e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 489 DADKMTQVLDNIISNAIKYSPDGGQVTFKVVLFQNYIETRISDQGVGIPKESLEKIFERFYRVDKARSRQLGGTGLGLAI 568
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 518998827 569 AKELVEAHGGKIWATSAEGKGTTIHFTLP 597
Cdd:cd16946 81 CHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
244-601 |
1.24e-25 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 109.17 E-value: 1.24e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 244 FNYLTKKLQEEQAKTESEKrklSSVLANMSDGVISTDRKGRIILINESAEKMLNISRDDVISKPLLAVLGIEDQYSVEDL 323
Cdd:COG3290 68 LAALLLKLLEEIARLVEER---EAVLESIREGVIAVDRDGRITLINDAARRLLGLDAIGRPIDEVLAEVLETGERDEEIL 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 324 FNEQgslvldygtktkplIFRANYSTIQKEtGKVNGLIVVLHDITEQEKIEME---RREFVYNV---SHELRTPLTTMKS 397
Cdd:COG3290 145 LNGR--------------VLVVNRVPIRDD-GRVVGAVATFRDRTELERLEEElegVKELAEALraqRHDFRNHLHTISG 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 398 YLEALSEGALQDenlapkflkVAQNETERMIRLVNDLLqlskIDSKDYRLDKewvdyirFLNRVIDRFemtKDESIVFVR 477
Cdd:COG3290 210 LLQLGEYDEALE---------YIDEISEELQELIDSLL----SRIGNPVLAA-------LLLGKAARA---RERGIDLTI 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 478 RFPKQPVYAEVDADKMTQVLDNIISNAI----KYSPDGGQVTFKVVLFQNYIETRISDQGVGIPKESLEKIFERFYRvdk 553
Cdd:COG3290 267 DIDSDLPDLPLSDTDLVTILGNLLDNAIeaveKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFS--- 343
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 518998827 554 arSRQLGGTGLGLAIAKELVEAHGGKIWATSAEGKGTTIHFTLPYDRD 601
Cdd:COG3290 344 --TKLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEGE 389
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-597 |
2.28e-25 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 100.48 E-value: 2.28e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 493 MTQVLDNIISNAIKYSPDGGQVTFKVVLFQNYIETRIS--DQGVGIPKESLEKIFERFYRVDkarSR-QLGGTGLGLAIA 569
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPPRIEVGAEDVGEEWTFYvrDNGIGIDPEYAEKVFGIFQRLH---SReEYEGTGVGLAIV 77
|
90 100
....*....|....*....|....*...
gi 518998827 570 KELVEAHGGKIWATSAEGKGTTIHFTLP 597
Cdd:cd16921 78 RKIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-597 |
6.42e-25 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 99.38 E-value: 6.42e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 493 MTQVLDNIISNAIKYSPDGGQVTFKVVLFQNYIETRISDQGVGIPKESLEKIFERFYRVDKarSRQLGGTGLGLAIAKEL 572
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDN--SRNTEGAGLGLSIAKAI 78
|
90 100
....*....|....*....|....*
gi 518998827 573 VEAHGGKIWATSaEGKGTTIHFTLP 597
Cdd:cd16923 79 IELHGGSASAEY-DDNHDLFKVRLP 102
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
377-597 |
8.31e-25 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 107.38 E-value: 8.31e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 377 RREFVYNVSHELRTPLTTMKsYLEALSEGALQDENLApkflkvaqneTERMI----RLVNDLLQLSKIDSKDYRLDKEWV 452
Cdd:PRK10604 212 KKQLIDGIAHELRTPLVRLR-YRLEMSDNLSAAESQA----------LNRDIgqleALIEELLTYARLDRPQNELHLSEP 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 453 DYIRFLNRVIDRFEMTKDESIVFVRRfPKQPVYAEVDADKMTQVLDNIISNAIKYSpdGGQVTFKVVLFQNYIETRISDQ 532
Cdd:PRK10604 281 DLPAWLSTHLADIQAVTPEKTVRLDT-PHQGDYGALDMRLMERVLDNLLNNALRYA--HSRVRVSLLLDGNQACLIVEDD 357
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 518998827 533 GVGIPKESLEKIFERFYRVDKARSRQLGGTGLGLAIAKELVEAHGGKIWATSAEGKGTTIHFTLP 597
Cdd:PRK10604 358 GPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWP 422
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
365-603 |
1.40e-24 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 109.44 E-value: 1.40e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 365 HDITEQEKI----EMERR----------EFVYNVSHELRTPLTTMKSYLEALSEGALQDENLApKFLKVAQNETERMIRL 430
Cdd:PRK09959 686 QDITETRDLihalEVERNkainatvaksQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRV-EAISLAYATGQSLLGL 764
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 431 VNDLLQLSKIDSKDYRLDKEWVDYIRFLNRVIDRF---EMTKDESIVFVRRFPKQPVyAEVDADKMTQVLDNIISNAIKY 507
Cdd:PRK09959 765 IGEILDVDKIESGNYQLQPQWVDIPTLVQNTCHSFgaiAASKSIALSCSSTFPDHYL-VKIDPQAFKQVLSNLLSNALKF 843
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 508 SPDGG-QVTFKVVLFQN---YIETRISDQGVGIPKESLEKIFERFYRVdkARSRQLGGTGLGLAIAKELVEAHGGKIWAT 583
Cdd:PRK09959 844 TTEGAvKITTSLGHIDDnhaVIKMTIMDSGSGLSQEEQQQLFKRYSQT--SAGRQQTGSGLGLMICKELIKNMQGDLSLE 921
|
250 260
....*....|....*....|
gi 518998827 584 SAEGKGTTIHFTLPYDRDQK 603
Cdd:PRK09959 922 SHPGIGTTFTITIPVEISQQ 941
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
370-598 |
6.91e-24 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 104.18 E-value: 6.91e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 370 QEKIEMeRREFVYN------------VSHELRTPLTTMKSYLEALSEGALQDENLApKFLKVAQNETERMIRLVNDLLQL 437
Cdd:COG5806 183 IENILL-RKELQRAeklevvselaasIAHEVRNPLTVVRGFIQLLQEPELSDEKRK-QYIRIALEELDRAEAIITDYLTF 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 438 SKIDSKDYrldkEWVDYIRFLNRVID---------RFEMTKDesivfvrrfPKQPVYAEVDADKMTQVLDNIISNAIKYS 508
Cdd:COG5806 261 AKPQPEKL----EKIDVSEELEHVIDvlspyanmnNVEIQTE---------LEPGLYIEGDRQKLQQCLINIIKNGIEAM 327
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 509 PDGGQVTFKVVLFQNYIETRISDQGVGIPKESLEKIFERFYrvdkarSRQLGGTGLGLAIAKELVEAHGGKIWATSAEGK 588
Cdd:COG5806 328 PNGGTLTIDVSIDKNKVIISIKDTGVGMTKEQLERLGEPYF------STKEKGTGLGTMVSYRIIEAMNGTIRVESEVGK 401
|
250
....*....|
gi 518998827 589 GTTIHFTLPY 598
Cdd:COG5806 402 GTTFTITLPL 411
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
385-597 |
9.76e-24 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 105.98 E-value: 9.76e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 385 SHELRTPLTTMKSYLEALSEGALQDEnlAPKFLKVAQNETERMIRLVNDLLQLSKIDSKDYRLDKEWVDYIRFLNRVIDR 464
Cdd:TIGR03785 493 SHELRTPVAVVRSSLENLELQALEQE--KQKYLERAREGTERLSMILNNMSEATRLEQAIQSAEVEDFDLSEVLSGCMQG 570
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 465 FEMTkDESIVFVRRFPKQPVYAEVDADKMTQVLDNIISNAIKYSPDGGQVTFKVVLFQNYIETRISDQGVGIPKESLEKI 544
Cdd:TIGR03785 571 YQMT-YPPQRFELNIPETPLVMRGSPELIAQMLDKLVDNAREFSPEDGLIEVGLSQNKSHALLTVSNEGPPLPEDMGEQL 649
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 518998827 545 FERFYRVDKARSRQLGGTGLGLAIAKELVEAHGGKIWA-TSAEGKGTTIHFTLP 597
Cdd:TIGR03785 650 FDSMVSVRDQGAQDQPHLGLGLYIVRLIADFHQGRIQAeNRQQNDGVVFRISLP 703
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
344-597 |
1.73e-23 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 105.49 E-value: 1.73e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 344 RANYSTIQKetgKVNGLIVVLHDITEQ-EKIEMERREFVYNVSHELRTPLTTMKSYLEALSEGALQDENLapKFLKVAQN 422
Cdd:PRK15347 367 NEQYDTLEN---KVAERTQALAEAKQRaEQANKRKSEHLTTISHEIRTPLNGVLGALELLQNTPLTAEQM--DLADTARQ 441
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 423 ETERMIRLVNDLLQLSKIDSKDYRLDKEWVDYIRFLNRV---IDRFEMTKDESI-VFVRrfPKQPVYAEVDADKMTQVLD 498
Cdd:PRK15347 442 CTLSLLAIINNLLDFSRIESGQMTLSLEETALLPLLDQAmltIQGPAQSKSLTLrTFVG--AHVPLYLHLDSLRLRQILV 519
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 499 NIISNAIKYSPDGG-QVTFKVVlfQNYIETRISDQGVGIPKESLEKIFERFYRVDKarsrQLGGTGLGLAIAKELVEAHG 577
Cdd:PRK15347 520 NLLGNAVKFTETGGiRLRVKRH--EQQLCFTVEDTGCGIDIQQQQQIFTPFYQADT----HSQGTGLGLTIASSLAKMMG 593
|
250 260
....*....|....*....|
gi 518998827 578 GKIWATSAEGKGTTIHFTLP 597
Cdd:PRK15347 594 GELTLFSTPGVGSCFSLVLP 613
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
483-592 |
1.32e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 92.85 E-value: 1.32e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 483 PVYAEVDADKMTQVLDNIISNAIKYSPDGGQVTFKVvlfQNYIET--RISDQGVGIPKESLEKIFERFYRVDKarsRQLG 560
Cdd:cd16940 4 DIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKL---SADDGAviRVEDNGPGIDEEELEALFERFYRSDG---QNYG 77
|
90 100 110
....*....|....*....|....*....|..
gi 518998827 561 GTGLGLAIAKELVEAHGGKIWATSAEGKGTTI 592
Cdd:cd16940 78 GSGLGLSIVKRIVELHGGQIFLGNAQGGGLEA 109
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
361-589 |
1.77e-21 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 99.28 E-value: 1.77e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 361 IVVLHDITEQEKIEMERRE--------------FVYNVSHELRTPLTTMKSYLEALSEGALQDEnlAPKFLKVAQNETER 426
Cdd:PRK10841 417 ICVLVDVSARVKMEESLQEmaqaaeqasqsksmFLATVSHELRTPLYGIIGNLDLLQTKELPKG--VDRLVTAMNNSSSL 494
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 427 MIRLVNDLLQLSKIDSKDYRLD------KEWVDYI--RFLNRVIdrfemTKDESI-VFVRrfPKQPVYAEVDADKMTQVL 497
Cdd:PRK10841 495 LLKIISDILDFSKIESEQLKIEprefspREVINHItaNYLPLVV-----KKRLGLyCFIE--PDVPVALNGDPMRLQQVI 567
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 498 DNIISNAIKYSpDGGQVTFKVVLFQNYIETRISDQGVGIPKESLEKIFERFYRVDKARSRQLGGTGLGLAIAKELVEAHG 577
Cdd:PRK10841 568 SNLLSNAIKFT-DTGCIVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMD 646
|
250
....*....|..
gi 518998827 578 GKIWATSAEGKG 589
Cdd:PRK10841 647 GDISVDSEPGMG 658
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
480-596 |
3.05e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 89.49 E-value: 3.05e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 480 PKQPVYAEVDADKMTQVLDNIISNAIKYSPDGGQVTFKVVLFQNYIETRISDQGVGIPKESLEKIFERFYRVDKARSRQL 559
Cdd:cd16947 8 PDRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAK 87
|
90 100 110
....*....|....*....|....*....|....*..
gi 518998827 560 GGTGLGLAIAKELVEAHGGKIWATSAEGKGTTIHFTL 596
Cdd:cd16947 88 QGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
376-589 |
3.54e-21 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 96.64 E-value: 3.54e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 376 ERReFVYNVSHELRTPLTTMKSYLEaLSEGALQDENLAPKFLKVAQNETERMIRLVNDLLQLSKIDSKDYRLDKEWVDYI 455
Cdd:PRK10337 237 ERR-FTSDAAHELRSPLAALKVQTE-VAQLSDDDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLE 314
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 456 RFLNR-VIDRFEMTKDESIVFVRRFPKQPVYAEVDADKMTQVLDNIISNAIKYSPDGGQVTfkVVLFQNYIetRISDQGV 534
Cdd:PRK10337 315 DLLQSaVMDIYHTAQQAGIDVRLTLNAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVD--VTLNARNF--TVRDNGP 390
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 518998827 535 GIPKESLEKIFERFYRvdkARSRQLGGTGLGLAIAKELVEAHGGKIWATSAEGKG 589
Cdd:PRK10337 391 GVTPEALARIGERFYR---PPGQEATGSGLGLSIVRRIAKLHGMNVSFGNAPEGG 442
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
489-597 |
2.57e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 86.19 E-value: 2.57e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 489 DADKMTQVLDNIISNAIKYSPDGGQVTFKVVLFQNYIETRISDQGVGIPKESLEKIFERFYRVDKARsRQLGGTGLGLAI 568
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGR-NFQESTGMGLYL 80
|
90 100
....*....|....*....|....*....
gi 518998827 569 AKELVEAHGGKIWATSAEGKGTTIHFTLP 597
Cdd:cd16948 81 VKKLCDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-597 |
6.69e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 82.09 E-value: 6.69e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 493 MTQVLDNIISNAIKYSPDggQVTFKVVLFQNYIETRISDQGVGIPKESLEKIFERFYRVDKARSRQLGGTGLGLAIAKEL 572
Cdd:cd16939 1 MARALDNLLRNALRYAHR--TVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRV 78
|
90 100
....*....|....*....|....*
gi 518998827 573 VEAHGGKIWATSAEGKGTTIHFTLP 597
Cdd:cd16939 79 ALWHGGHVECDDSELGGACFRLTWP 103
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
384-600 |
1.47e-18 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 88.43 E-value: 1.47e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 384 VSHELRTPLTTMKSYLEALSEgalQDENLAPKFLKvaqnETERMIRLVNDLLqlskidskDY-RLDKEWVDYIRFLNRVI 462
Cdd:PRK09467 236 VSHDLRTPLTRIRLATEMMSE---EDGYLAESINK----DIEECNAIIEQFI--------DYlRTGQEMPMEMADLNALL 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 463 DrfEMTKDES---IVFVRRFPKQPVYAEVDADKMTQVLDNIISNAIKYSPDGGQV----TFKVVLFQnyietrISDQGVG 535
Cdd:PRK09467 301 G--EVIAAESgyeREIETALQPGPIEVPMNPIAIKRALANLVVNAARYGNGWIKVssgtEGKRAWFQ------VEDDGPG 372
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518998827 536 IPKESLEKIFERFYRVDKARSRQlgGTGLGLAIAKELVEAHGGKI-WATSAEGkGTTIHFTLPYDR 600
Cdd:PRK09467 373 IPPEQLKHLFQPFTRGDSARGSS--GTGLGLAIVKRIVDQHNGKVeLGNSEEG-GLSARAWLPLTT 435
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
489-580 |
2.33e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 80.58 E-value: 2.33e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 489 DADKMTQVLDNIISNAIKYSPDGGQVTFKVVLFQNYIETRISDQGVGIPKESLEKIFERFYRVDKARsRQLGGTGLGLAI 568
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSR-RSGGHYGMGLYI 79
|
90
....*....|..
gi 518998827 569 AKELVEAHGGKI 580
Cdd:cd16975 80 AKNLVEKHGGSL 91
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
376-442 |
2.63e-18 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 79.18 E-value: 2.63e-18
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518998827 376 ERREFVYNVSHELRTPLTTMKSYLEALSEGALQDEnlAPKFLKVAQNETERMIRLVNDLLQLSKIDS 442
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEE--QREYLETILRSAERLLRLINDLLDLSRIEA 65
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
495-580 |
2.86e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 80.58 E-value: 2.86e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 495 QVLDNIISNAIKYSPDGGQVTFKVVLFQNYIETRISDQGVGIPKESLEKIFERFYRVDKARSRQlGGTGLGLAIAKELVE 574
Cdd:cd16945 7 QAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQ-KSTGLGLAFVQEVAQ 85
|
....*.
gi 518998827 575 AHGGKI 580
Cdd:cd16945 86 LHGGRI 91
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
376-442 |
7.39e-18 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 77.99 E-value: 7.39e-18
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518998827 376 ERREFVYNVSHELRTPLTTMKSYLEALSEGALQDENLapKFLKVAQNETERMIRLVNDLLQLSKIDS 442
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQR--EYLETILREAERLLRLINDLLDLSRIEA 65
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-597 |
7.99e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 79.03 E-value: 7.99e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 493 MTQVLDNIISNAIKYSpdGGQVTFKVVLFQNYIETRISDQGVGIPKESLEKIFERFYRVDKARSrqLGGTGLGLAIAKEL 572
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQRI 76
|
90 100
....*....|....*....|....*
gi 518998827 573 VEAHGGKIWATSAEGKGTTIHFTLP 597
Cdd:cd16950 77 SDAHGGSLTLANRAGGGLCARIELP 101
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
379-599 |
1.35e-17 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 86.83 E-value: 1.35e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 379 EFVYNVSHELRTPL----------------TTMKSYLEALSEGAlqdENLapkflkvaqnetermIRLVNDLLQLSKIDS 442
Cdd:PRK11107 295 EFLANMSHELRTPLngvigftrqtlktpltPTQRDYLQTIERSA---NNL---------------LAIINDILDFSKLEA 356
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 443 KDYRLDKewvdyIRF-----LNRVI---------DRFEMTKDESivfvrrfPKQPVYAEVDADKMTQVLDNIISNAIKYS 508
Cdd:PRK11107 357 GKLVLEN-----IPFslretLDEVVtllahsaheKGLELTLNID-------PDVPDNVIGDPLRLQQIITNLVGNAIKFT 424
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 509 pDGGQVTFKVVL---FQNYIETR--ISDQGVGIPKESLEKIFERFYRVDKARSRQLGGTGLGLAIAKELVEAHGGKIWAT 583
Cdd:PRK11107 425 -ESGNIDILVELralSNTKVQLEvqIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQKLVNEMGGDISFH 503
|
250
....*....|....*.
gi 518998827 584 SAEGKGTTIHFTLPYD 599
Cdd:PRK11107 504 SQPNRGSTFWFHLPLD 519
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
268-597 |
1.45e-17 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 84.36 E-value: 1.45e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 268 VLANMSDGVISTDRKGRIILINESAEKMLNISRDDVISKPLLAVLG---IEDQYSVEDLFNEQG------SLVLDygtkT 338
Cdd:PRK11073 12 ILNSLINSILLLDDDLAIHYANPAAQQLLAQSSRKLFGTPLPELLSyfsLNIELMRESLQAGQGftdnevTLVID----G 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 339 KPLIFRANYSTIQketgkvNGLIVV-LHDITEQEKIEMER---------REFVYNVSHELRTPLTTMKSYLEALSEgALQ 408
Cdd:PRK11073 88 RSHILSLTAQRLP------EGMILLeMAPMDNQRRLSQEQlqhaqqvaaRDLVRGLAHEIKNPLGGLRGAAQLLSK-ALP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 409 DENLApKFLKVAQNETERMIRLVNDLLQLSKIDSKDyrldKEWVDYIrfLNRVIDRFEMTKDESIVFVRRF-PKQPVYaE 487
Cdd:PRK11073 161 DPALT-EYTKVIIEQADRLRNLVDRLLGPQRPGTHV----TESIHKV--AERVVQLVSLELPDNVRLIRDYdPSLPEL-A 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 488 VDADKMTQVLDNIISNAIK-YSPDGGQVTFKV-VLFQNYI---------ETRISDQGVGIPKESLEKIFerfYRVDKARS 556
Cdd:PRK11073 233 HDPDQIEQVLLNIVRNALQaLGPEGGTITLRTrTAFQLTLhgeryrlaaRIDIEDNGPGIPPHLQDTLF---YPMVSGRE 309
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 518998827 557 rqlGGTGLGLAIAKELVEAHGGKIWATSAEGKgTTIHFTLP 597
Cdd:PRK11073 310 ---GGTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLP 346
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
374-439 |
2.18e-17 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 76.48 E-value: 2.18e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518998827 374 EMERREFVYNVSHELRTPLTTMKSYLEALSEGALQDENLApKFLKVAQNETERMIRLVNDLLQLSK 439
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQR-EYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
495-597 |
5.19e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 76.67 E-value: 5.19e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 495 QVLDNIISNAIKySPDGGQVTFKVVLFQN------YIETRISDQGVGIPKESLEKIFERFYRVDKArsrqlgGTGLGLAI 568
Cdd:cd16920 3 QVLINLVRNGIE-AMSEGGCERRELTIRTspaddrAVTISVKDTGPGIAEEVAGQLFDPFYTTKSE------GLGMGLSI 75
|
90 100
....*....|....*....|....*....
gi 518998827 569 AKELVEAHGGKIWATSAEGKGTTIHFTLP 597
Cdd:cd16920 76 CRSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-592 |
5.85e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 76.84 E-value: 5.85e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 493 MTQVLDNIISNAIKYSP-DGGQVTFKVVLFQNYIETRISDQGVGIPKESLEKIFERFYrVDKARSRQLG-GTGLGLAIAK 570
Cdd:cd16953 1 LGQVLRNLIGNAISFSPpDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFY-TERPANEAFGqHSGLGLSISR 79
|
90 100
....*....|....*....|..
gi 518998827 571 ELVEAHGGKIWATSAEGKGTTI 592
Cdd:cd16953 80 QIIEAHGGISVAENHNQPGQVI 101
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
369-597 |
1.20e-16 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 83.96 E-value: 1.20e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 369 EQEKIEMERR-----------EFVYNVSHELRTPLTTMKSYLEaLSEGALQDENLAPKFLKVAQNETERMIRLVNDLLQL 437
Cdd:PRK13837 431 ETERDALERRleharrleavgTLASGIAHNFNNILGAILGYAE-MALNKLARHSRAARYIDEIISAGARARLIIDQILAF 509
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 438 SkidskdyrldkewvdyiRFLNRVIDRFEMTK--DESIVFVR-----------RFPKQPVYAEVDADKMTQVLDNIISNA 504
Cdd:PRK13837 510 G-----------------RKGERNTKPFDLSElvTEIAPLLRvslppgveldfDQDQEPAVVEGNPAELQQVLMNLCSNA 572
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 505 IKYSPDGGQVTFKV---------VLFQ------NYIETRISDQGVGIPKESLEKIFERFYrvdKARSrqlGGTGLGLAIA 569
Cdd:PRK13837 573 AQAMDGAGRVDISLsraklrapkVLSHgvlppgRYVLLRVSDTGAGIDEAVLPHIFEPFF---TTRA---GGTGLGLATV 646
|
250 260
....*....|....*....|....*...
gi 518998827 570 KELVEAHGGKIWATSAEGKGTTIHFTLP 597
Cdd:PRK13837 647 HGIVSAHAGYIDVQSTVGRGTRFDVYLP 674
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
369-600 |
2.69e-16 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 82.65 E-value: 2.69e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 369 EQEKIEMERREFVYNVSHELRTPLTTMKSYLEALSEGALQdeNLAPKFLKVAQNETERMIRLVNDLLQLSKID--SKDYR 446
Cdd:PRK11466 436 EAEKASQAKSAFLAAMSHEIRTPLYGILGTAQLLADNPAL--NAQRDDLRAITDSGESLLTILNDILDYSAIEagGKNVS 513
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 447 LDKEWVDYIRFLNRVIDRFE-MTKDESIVFVRRFPKQ-PVYAEVDADKMTQVLDNIISNAIKYSpDGGQVTFKVVLFQNY 524
Cdd:PRK11466 514 VSDEPFEPRPLLESTLQLMSgRVKGRPIRLATDIADDlPTALMGDPRRIRQVITNLLSNALRFT-DEGSIVLRSRTDGEQ 592
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518998827 525 IETRISDQGVGIPKESLEKIFERFYRVDKARsrqlGGTGLGLAIAKELVEAHGGKIWATSAEGKGTTIHFTLPYDR 600
Cdd:PRK11466 593 WLVEVEDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPLRV 664
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
495-597 |
2.26e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 72.07 E-value: 2.26e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 495 QVLDNIISNAIKYSPDGGQVTFKVVLFQNYIETRISDQGVGIPKESLEKIFERFYRvdkarSRQLG-GTGLGLAIAKELV 573
Cdd:cd16943 6 QVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFT-----TKPVGeGTGLGLSLSYRII 80
|
90 100
....*....|....*....|....
gi 518998827 574 EAHGGKIWATSAEGKGTTIHFTLP 597
Cdd:cd16943 81 QKHGGTIRVASVPGGGTRFTIILP 104
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
489-597 |
3.97e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 71.41 E-value: 3.97e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 489 DADKMTQVLDNIISNA---IKYSPDG-GQVTFKVVL-FQNYIETRISDQGVGIPKESLEKIFERfYRVDKARsrqlgGTG 563
Cdd:cd16944 1 DTTQISQVLTNILKNAaeaIEGRPSDvGEVRIRVEAdQDGRIVLIVCDNGKGFPREMRHRATEP-YVTTRPK-----GTG 74
|
90 100 110
....*....|....*....|....*....|....
gi 518998827 564 LGLAIAKELVEAHGGKIWATSAEGKGTTIHFTLP 597
Cdd:cd16944 75 LGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
495-586 |
3.08e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 69.97 E-value: 3.08e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 495 QVLDNIISNAIKYSpdGGQVTFKVVLFQNYIETRISDQGVGIPKESLEKIFERFYRVDKARSrqlgGTGLGLAIAKELVE 574
Cdd:cd16954 40 ELLGNLLDNACKWC--LEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDEQRP----GQGLGLAIAKEIVE 113
|
90
....*....|..
gi 518998827 575 AHGGKIWATSAE 586
Cdd:cd16954 114 QYGGELSLSDSP 125
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
340-579 |
3.43e-14 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 74.23 E-value: 3.43e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 340 PLIFRANYSTIQKETGKVNGLIVVLHDITEQEkiemerREFVYNVSHELRTPLTTMKSYLEALSEGALQDenLAPKFLKV 419
Cdd:PRK10755 106 PIAIHSSTLEIEAVTSALNQLVSRLTSTLDQE------RLFTADVAHELRTPLAGIRLHLELLEKQHHID--VAPLIARL 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 420 AQneterMIRLVNDLLQLSkidskdyRLDKEWV----DYIRFLNRVID--RFEM-----TKDESIVFVRrfPKQPVYAEV 488
Cdd:PRK10755 178 DQ-----MMHTVEQLLQLA-------RAGQSFSsghyQTVKLLEDVILpsQDELsemleQRQQTLLLPE--SAADITVQG 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 489 DADKMTQVLDNIISNAIKYSPDGGQVTFKVVLFQNYIETRISDQGVGIPKESLEKIFERFYRVDkarsRQLGGTGLGLAI 568
Cdd:PRK10755 244 DATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRMD----SRYGGIGLGLSI 319
|
250
....*....|.
gi 518998827 569 AKELVEAHGGK 579
Cdd:PRK10755 320 VSRITQLHHGQ 330
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
207-251 |
3.58e-14 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 66.70 E-value: 3.58e-14
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 518998827 207 TRPLSDMRSQAQAMAKGNFSRKVKVYSQDEIGQLAQTFNYLTKKL 251
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
495-597 |
2.44e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 66.63 E-value: 2.44e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 495 QVLDNIISNAIKYSPDGGQVTFKV---------------VLFQNYIETRISDQGVGIPKESLEKIFERFYRvdkarSRQL 559
Cdd:cd16919 3 LAILNLAVNARDAMPEGGRLTIETsnqrvdadyalnyrdLIPGNYVCLEVSDTGSGMPAEVLRRAFEPFFT-----TKEV 77
|
90 100 110
....*....|....*....|....*....|....*....
gi 518998827 560 G-GTGLGLAIAKELVEAHGGKIWATSAEGKGTTIHFTLP 597
Cdd:cd16919 78 GkGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
253-379 |
5.35e-13 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 69.28 E-value: 5.35e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 253 EEQAKTESEKRKLSSVLANMSDGVISTDRKGRIILINESAEKMLNISRDDVISKPLLAVLGIEDQYSV----EDLFNEQG 328
Cdd:COG2202 1 TAEEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLPPEDDDEFlellRAALAGGG 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 518998827 329 SLVLDYGTKTK---PLIFRANYSTIQKETGKVNGLIVVLHDITEQEKIEMERRE 379
Cdd:COG2202 81 VWRGELRNRRKdgsLFWVELSISPVRDEDGEITGFVGIARDITERKRAEEALRE 134
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
266-604 |
5.80e-13 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 71.48 E-value: 5.80e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 266 SSVLANMSDGVISTDRKGRIILINESAEKMLNISR---DDVISKPLLAVLGIED----------QYSVEDLFNeqGSLVL 332
Cdd:PRK11086 224 QAMLQSIKEGVIAVDDRGEVTLINDEAKRLFNYKKgleDDPLGTDVESWMPVSRlkevlrtgtpRRDEEININ--GRLLL 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 333 dygTKTKPLIFRanystiqketGKVNGLIVVLHDITEQEKIeMERrefvynvshelrtpLTTMKSYLEALSE-------- 404
Cdd:PRK11086 302 ---TNTVPVRVN----------GEIIGAIATFRDKTEVRQL-AQR--------------LDGMVNYADALRAqshefmnk 353
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 405 -----GALQDEN---LAPKFLKVAQN---ETERMIRLVND-------LLQLSKIDSKDYRLDKEWVDYIrflnrvidrfE 466
Cdd:PRK11086 354 lhvilGLLHLKSydqLEDYILKTANNyqeEIGSLLGKIKSpviagflLGKISRARELGITLIISEDSQL----------P 423
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 467 MTKDESIVFVrrfpkqpvyaevdadkMTQVLDNIISNAIKY--SPDGGQVTFKVVLFQNYIETRISDQGVGIPKESLEKI 544
Cdd:PRK11086 424 DSGDEDQVHE----------------LITILGNLIENALEAvgGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAI 487
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 545 FERFYrvdkarSRQLGGTGLGLAIAKELVEAHGGKIWATSAEGKGTTIHFTLPYDRDQKD 604
Cdd:PRK11086 488 FDKGY------STKGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIPWDGERSN 541
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
263-367 |
1.13e-12 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 64.75 E-value: 1.13e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 263 RKLSSVLANMSDGVISTDRKGRIILINESAEKMLNISRDDVISKPLLAVLGIEDQYSVEDLF--------NEQGSLVLDY 334
Cdd:pfam00989 1 EDLRAILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIPEEDDAEVAELLrqallqgeESRGFEVSFR 80
|
90 100 110
....*....|....*....|....*....|...
gi 518998827 335 GTKTKPLIFRANYSTIQKETGKVNGLIVVLHDI 367
Cdd:pfam00989 81 VPDGRPRHVEVRASPVRDAGGEILGFLGVLRDI 113
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
6-253 |
1.53e-12 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 70.05 E-value: 1.53e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 6 LFTSIRLKFILFFVLLILIAMQIIGVYFVRELETKLTENFKESILSRVKFLTYNVEQEFMKERVDSGQLSLELAI--DKI 83
Cdd:COG0840 4 LLLLLALLLALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALvvLLA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 84 LKENTSSDINEIRVIDKNMRVIGTSDENNEDIVGQRTTDVLATRAFATEENIDQLVIDPNNGRTWVLYVPIKVRNNVEGL 163
Cdd:COG0840 84 LLLALLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAAL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 164 IYLEGKIEKVFDQIQVINGVLVKGTVIASGITAILAIFVAQTITRPLSDMRSQAQAMAKGNFSRKVKVYSQDEIGQLAQT 243
Cdd:COG0840 164 AALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADA 243
|
250
....*....|
gi 518998827 244 FNYLTKKLQE 253
Cdd:COG0840 244 FNRMIENLRE 253
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
253-379 |
1.59e-12 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 69.80 E-value: 1.59e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 253 EEQAKTESEKRKLSSVLANMSDGVISTDRKGRIILINESAEKMLNISRDDVISKPLLAVlgIEDQYSVEDLFNEQGSLVL 332
Cdd:COG3829 1 AEELELKELEEELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVTEL--IPNSPLLEVLKTGKPVTGV 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 518998827 333 DYGTKTKPLIFRANYSTIqKETGKVNGLIVVLHDITEQEKIEMERRE 379
Cdd:COG3829 79 IQKTGGKGKTVIVTAIPI-FEDGEVIGAVETFRDITELKRLERKLRE 124
|
|
| HAMP |
pfam00672 |
HAMP domain; |
201-253 |
4.75e-12 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 61.10 E-value: 4.75e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 518998827 201 FVAQTITRPLSDMRSQAQAMAKGNFSRKVKVYSQDEIGQLAQTFNYLTKKLQE 253
Cdd:pfam00672 1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
496-597 |
6.43e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 62.30 E-value: 6.43e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 496 VLDNIISNAIKYSPDGGQVTFKVVLFQNY----IETRISDQGVGIPKESLEKIFERFYRvdkarSRQLGGTGLGLAIAKE 571
Cdd:cd16915 4 IVGNLIDNALDALAATGAPNKQVEVFLRDegddLVIEVRDTGPGIAPELRDKVFERGVS-----TKGQGERGIGLALVRQ 78
|
90 100
....*....|....*....|....*.
gi 518998827 572 LVEAHGGKIWATSAEGKGTTIHFTLP 597
Cdd:cd16915 79 SVERLGGSITVESEPGGGTTFSIRIP 104
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
205-256 |
8.73e-12 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 60.34 E-value: 8.73e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 518998827 205 TITRPLSDMRSQAQAMAKGNFSRKVKVYSQDEIGQLAQTFNYLTKKLQEEQA 256
Cdd:smart00304 2 RLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-597 |
9.24e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 62.03 E-value: 9.24e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 493 MTQVLDNIISNAIKYSPDGG-----------QVTFKVVLFQNYIETRISDQGVGIPKESLEKIFERFYrvdkarSRQLGG 561
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGSGgeiilrtrtqrQVTLGHPRHRLALRVSVIDNGPGIPPDLQDTIFYPMV------SGRENG 74
|
90 100 110
....*....|....*....|....*....|....*.
gi 518998827 562 TGLGLAIAKELVEAHGGKIWATSAEGKgTTIHFTLP 597
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
176-589 |
6.86e-11 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 65.09 E-value: 6.86e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 176 QIQVINGVLVkGTVIASGITAILA--IFVAQTITRPLSDMRSQAQAMAKGNFSRKVKVYSQDEIGQLAQTFNYLTKKLQE 253
Cdd:COG4192 320 LVQQSGILLL-AIALLSLLLAVLInyFYVRRRLVKRLNALSDAMAAIAAGDLDVPIPVDGNDEIGRIARLLRVFRDQAIE 398
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 254 --EQAKTESEKRKLssvlanmsdgvistdrkgriilinesAEKMLNISRDDVISKPLLAVLGiedqysvedlfneqgslv 331
Cdd:COG4192 399 ktQELETEIEERKR--------------------------IEKNLRQTQDELIQAAKMAVVG------------------ 434
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 332 ldygtktkplifranystiqketgkvnglivvlhditeqekiemerrEFVYNVSHELRTPLTTMKSYLEALsEGALQDEN 411
Cdd:COG4192 435 -----------------------------------------------QTMTSLAHELNQPLNAMSMYLFSA-KKALEQEN 466
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 412 L--APKFLKVAQNETERMIRLVNDLLQLSKIDSKDYRLdkewVDyirfLNRVIdrfemTKDESIVFVRRFPKQ------- 482
Cdd:COG4192 467 YaqLPTSLDKIEGLIERMDKIIKSLRQFSRKSDTPLQP----VD----LRQVI-----EQAWELVESRAKPQQitlhipd 533
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 483 PVYAEVDADKMTQVLDNIISNAIKYSPDGGQVTFKVVLFQNYIETRISDQGVGIPkeSLEKIFERFYrvdkarSRQLGGT 562
Cdd:COG4192 534 DLMVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGWP--LVDKLFTPFT------TTKEVGL 605
|
410 420
....*....|....*....|....*..
gi 518998827 563 GLGLAIAKELVEAHGGKIWATSAEGKG 589
Cdd:COG4192 606 GLGLSICRSIMQQFGGDLYLASTLERG 632
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
248-377 |
6.39e-10 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 60.04 E-value: 6.39e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 248 TKKLQEEQAKTESEKRkLSSVLANMSDGVISTDRKGRIILINESAEKMLNISRDDVISKPLLAVLGIEDQYSVEDLFNE- 326
Cdd:COG2202 123 TERKRAEEALRESEER-LRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKSLLDLLHPEDRERLLELLRRl 201
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 518998827 327 ----QGSLVLDYGTKTK---PLIFRANYSTIQKEtGKVNGLIVVLHDITEQEKIEMER 377
Cdd:COG2202 202 leggRESYELELRLKDGdgrWVWVEASAVPLRDG-GEVIGVLGIVRDITERKRAEEAL 258
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
263-327 |
9.90e-10 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 54.71 E-value: 9.90e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 518998827 263 RKLSSVLANMSDGVISTDRKGRIILINESAEKMLNISRDDVISKPLLAVLGIEDQYSVEDLFNEQ 327
Cdd:smart00091 1 ERLRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHPEDRERVQEALQRL 65
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
1-333 |
1.18e-09 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 61.28 E-value: 1.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 1 MRKLNLFTSIRLKFILFFVLLILIAMQIIGVYFVRELETKLTENFKESILSRVKFLTYNVEQEFMKERVDSGQLSLELAI 80
Cdd:COG2770 35 LLLALLLLLLLLLALLLLLLLLLLLLLAALVLLALLLAAALLLLLLLLSLVALAALLLALLLLLLLALLLLLAALLLLLL 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 81 DKILKENTSSDINEIRVIDKNMRVIGTSDENNEDIVGQRTTDVLATRAFATEENIDQLVIDPNNGRTWVLYVPIKVRNNV 160
Cdd:COG2770 115 LAALALLLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAALALALGAGELLLLADLAAAIAALLAALLLLL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 161 EGLIYLEGKIEKVFDQIQVINGVlvkgTVIASGITAILAIFVAQTITRPLSDMRSQAQAMAKGNFSRKVKVYSQDEIGQL 240
Cdd:COG2770 195 LGGLLLVVLLEAALAALLLLLLL----ALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKDEIGEL 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 241 AQTFNYLTKKLQEEQAKTESEKRKLSSVLANMSDGVISTDRKGRIILINESAEKMLNISRDDVISKPLLAVLGIEDQYSV 320
Cdd:COG2770 271 ARAFNRMADSLRESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADL 350
|
330
....*....|...
gi 518998827 321 EDLFNEQGSLVLD 333
Cdd:COG2770 351 LLALALAALLLLL 363
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
501-597 |
2.18e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 54.48 E-value: 2.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 501 ISNAIKYSPdGGQVTFKVVLFQNYIETRISDQGVGIPKESlekiferfyrvdkarsrQLGGTGLGLAIAKELVEAHGGKI 580
Cdd:cd16917 9 LTNALKHAG-ASRVRVTLSYTADELTLTVVDDGVGFDGPA-----------------PPGGGGFGLLGMRERAELLGGTL 70
|
90
....*....|....*..
gi 518998827 581 WATSAEGKGTTIHFTLP 597
Cdd:cd16917 71 TIGSRPGGGTRVTARLP 87
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
495-596 |
2.45e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 54.77 E-value: 2.45e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 495 QVLDNIISNAIK--YSPDGGQVTFKVVLFQNYIETRISDQGVGIPKESLEKIFERFYRvdkarSRQLG-GTGLGLAIAKE 571
Cdd:cd16976 3 QVLMNLLQNALDamGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFT-----TKPVGkGTGLGLSISYG 77
|
90 100
....*....|....*....|....*
gi 518998827 572 LVEAHGGKIWATSAEGKGTTIHFTL 596
Cdd:cd16976 78 IVEEHGGRLSVANEEGAGARFTFDL 102
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
91-332 |
2.79e-09 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 59.51 E-value: 2.79e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 91 DINEIRVIDKNMRVIGTSDENNEDIVGQRTTDVLATRAFATEENIDQLVIDPNNGRTWVLYVPIKVRNNVEGLIYLEGKI 170
Cdd:COG3850 27 LLLSLLALLLLLERTLLRLLSLLASAGLLAALLAALLLLLSLGLLALLLALLLLLLLLLLAALLSLLLLLLLLLLLLLLL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 171 EKVFDQIQVINGVLVKGTVIASGITAILAIFVAQTITRPLSDMRSQAQAMAKGNFSRKVKVYSQDEIGQLAQTFNYLTKK 250
Cdd:COG3850 107 LLLLLAAAINRKLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFNRMADE 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 251 LQEEQAKTESEKRKLSSVLANMSDGVISTDRKGRIILINESAEKMLNISRDDVISKPLLAVLGIEDQYSVEDLFNEQGSL 330
Cdd:COG3850 187 LQELYAELEEEEELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELLALNILAGLLELL 266
|
..
gi 518998827 331 VL 332
Cdd:COG3850 267 LA 268
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
31-267 |
4.21e-09 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 58.88 E-value: 4.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 31 VYFVRELETKLTENFKESILSRVKFLTYNVEQEFMKERVDSGQLSLELAIDKILKENTSSDINEIRVIDKNMRVIGTSDE 110
Cdd:COG2972 5 LSLLSIVLLLLILLLLVLLILLLSLLLIILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLILL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 111 NNEDIVGQRTTDVLATRAFATEENIDQLVIDPNNGRTWVLYVPIKVRNNVEGL-IYLEGKIEKVFDQIQVINGVLVKGTV 189
Cdd:COG2972 85 LLLLLLLLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWtLVSLIPKSELFRGLFSLRRLILLIIL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 190 IASGITAILAIFVAQTITRPLSDMRSQAQAMAKGNFSRkVKVYSQDEIGQLAQTFNYLTKKLQE--------EQAKTESE 261
Cdd:COG2972 165 LLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLVR-LEVSGNDEIGILARSFNEMVERIKElieevyelELEKKEAE 243
|
....*.
gi 518998827 262 KRKLSS 267
Cdd:COG2972 244 LKALQA 249
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
272-367 |
4.66e-09 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 54.18 E-value: 4.66e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 272 MSDGVISTDRKGRIILINESAEKMLNISRDDVISKPLLAVLGIEDQY----SVEDLFNEQGSLVLDYGTKTK---PLIFR 344
Cdd:cd00130 1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREelreRLENLLSGGEPVTLEVRLRRKdgsVIWVL 80
|
90 100
....*....|....*....|...
gi 518998827 345 ANYSTIQKETGKVNGLIVVLHDI 367
Cdd:cd00130 81 VSLTPIRDEGGEVIGLLGVVRDI 103
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
392-601 |
5.03e-09 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 57.32 E-value: 5.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 392 LTTMKSYLEALSEGALQDENLAPKFLKVAQNETERMIRLVNDLL-QLSKIDSKDYRLDKEWVDYIRflnrvidrfEMTKD 470
Cdd:COG4585 69 LSAIKLQLEAARRLLDADPEAAREELEEIRELAREALAELRRLVrGLRPPALDDLGLAAALEELAE---------RLLRA 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 471 ESIVFVRRFPKQPVyaEVDADKMTQVLDNI---ISNAIKYSPdGGQVTFKVVLFQNYIETRISDQGVGIPKEslekifer 547
Cdd:COG4585 140 AGIRVELDVDGDPD--RLPPEVELALYRIVqeaLTNALKHAG-ATRVTVTLEVDDGELTLTVRDDGVGFDPE-------- 208
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 518998827 548 fyrvdkarsrQLGGTGLGLAIAKELVEAHGGKIWATSAEGKGTTIHFTLPYDRD 601
Cdd:COG4585 209 ----------AAPGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPLAAA 252
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
475-597 |
1.13e-08 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 53.76 E-value: 1.13e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 475 FVRRFPKQPVYAEVDADKMTQVLDNIISNAIKYS---PDGGQVTFKVVLFQNYIETRISDQGVGIPKESLEKIFErfyrv 551
Cdd:COG2172 17 AVRALLRELGLDEDDADDLVLAVSEAVTNAVRHAyggDPDGPVEVELELDPDGLEIEVRDEGPGFDPEDLPDPYS----- 91
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 518998827 552 dkarsrQLGGTGLGLAIAKELVEAhggkiWATSAEGKGTTIHFTLP 597
Cdd:COG2172 92 ------TLAEGGRGLFLIRRLMDE-----VEYESDPGGTTVRLVKR 126
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
495-584 |
1.15e-08 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 57.72 E-value: 1.15e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 495 QVLDNIISNAIKYSPDGGQVTfkVVLFQNYIETRISDQGVGIPKESLEKIFERFYRVDKARSrqlgGTGLGLAIAKELVE 574
Cdd:PRK10815 381 EVMGNVLDNACKYCLEFVEIS--ARQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRP----GQGLGLSVAREITE 454
|
90
....*....|
gi 518998827 575 AHGGKIWATS 584
Cdd:PRK10815 455 QYEGKISAGD 464
|
|
| PAS_9 |
pfam13426 |
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ... |
282-369 |
1.38e-07 |
|
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463873 [Multi-domain] Cd Length: 93 Bit Score: 49.77 E-value: 1.38e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 282 KGRIILINESAEKMLNISRDDVISKPLLAVLGIEDQYS----VEDLFNEQGSLVLDYGTKT-KPLIFRANYSTIQKETGK 356
Cdd:pfam13426 1 DGRIIYVNDAALRLLGYTREELLGKSITDLFAEPEDSErlreALREGKAVREFEVVLYRKDgEPFPVLVSLAPIRDDGGE 80
|
90
....*....|...
gi 518998827 357 VNGLIVVLHDITE 369
Cdd:pfam13426 81 LVGIIAILRDITE 93
|
|
| PAS_4 |
pfam08448 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
269-371 |
1.64e-07 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain is associated to signalling systems and works as a signal sensor domain. It recognizes differently substituted aromatic hydrocarbons, oxygen, different dodecanoic acids, autoinducers, 3,5-dimethyl-pyrazin-2-ol and N-alanyl-aminoacetone (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 312075 [Multi-domain] Cd Length: 110 Bit Score: 49.72 E-value: 1.64e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 269 LANMSDGVISTDRKGRIILINESAEKMLNISRDDVISKPLLAVLGIEDQYSVEDLFNE--QG----SLVLDYGTKTKPLI 342
Cdd:pfam08448 1 LDSLPDALAVLDPDGRVRYANAAAAELFGLPPEELLGKTLAELLPPEDAARLERALRRalEGeepiDFLEELLLNGEERH 80
|
90 100
....*....|....*....|....*....
gi 518998827 343 FRANYSTIQKETGKVNGLIVVLHDITEQE 371
Cdd:pfam08448 81 YELRLTPLRDPDGEVIGVLVISRDITERR 109
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
384-605 |
1.74e-07 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 53.91 E-value: 1.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 384 VSHELRTPLTTMKSYLEALSEGALQDENLAPKFLKVAQN---ETERMIRLVNDLLQLSKidskDYRLDKEWVDyirfLNR 460
Cdd:PRK13557 170 IAHDFNNLLQVMSGYLDVIQAALSHPDADRGRMARSVENiraAAERAATLTQQLLAFAR----KQRLEGRVLN----LNG 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 461 VIDRF----EMTKDESIVFVRRFPKQPVYAEVDADKMTQVLDNIISNAIKYSPDGGQVT---------------FKVVLF 521
Cdd:PRK13557 242 LVSGMgelaERTLGDAVTIETDLAPDLWNCRIDPTQAEVALLNVLINARDAMPEGGRVTirtrnveiededlamYHGLPP 321
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 522 QNYIETRISDQGVGIPKESLEKIFERFYrVDKARSRqlgGTGLGLAIAKELVEAHGGKIWATSAEGKGTTIHFTLPYDRD 601
Cdd:PRK13557 322 GRYVSIAVTDTGSGMPPEILARVMDPFF-TTKEEGK---GTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFPASDQ 397
|
....
gi 518998827 602 QKDD 605
Cdd:PRK13557 398 AENP 401
|
|
| TyrR |
COG3283 |
Transcriptional regulator TyrR of aromatic amino acids metabolism [Transcription, Amino acid ... |
258-313 |
2.89e-07 |
|
Transcriptional regulator TyrR of aromatic amino acids metabolism [Transcription, Amino acid transport and metabolism];
Pssm-ID: 442513 [Multi-domain] Cd Length: 514 Bit Score: 53.27 E-value: 2.89e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 518998827 258 TESEKRKLSSVLANMSDGVISTDRKGRIILINESAEKMLNISRDDVISKPLLAVLG 313
Cdd:COG3283 75 SEREHLELDALLEALPDPVFSIDLKGKIELANPAALSLLGLSEEELIGQPLSELLK 130
|
|
| HATPase_Phy-like |
cd16932 |
Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana ... |
489-574 |
1.14e-06 |
|
Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana Phytochrome A, B, C, D and E; This family includes the histidine kinase-like ATPase (HATPase) domains of plant red/far-red photoreceptors, the phytochromes, and includes the Arabidopsis thaliana phytochrome family phyA-phyE. Following red light absorption, biologically inactive forms of phytochromes convert to active forms, which rapidly convert back to inactive forms upon far-red light irradiation. Phytochromes can be considered as having an N-terminal photosensory region to which a bilin chromophore is bound, and a C-terminal output region, which includes the HATPase domain represented here, and is involved in dimerization and presumably contributes to relaying the light signal to downstream signaling events.
Pssm-ID: 340409 [Multi-domain] Cd Length: 113 Bit Score: 47.65 E-value: 1.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 489 DADKMTQVLDNIISNAIKYSP-DGGQVTFKVVLFQNYI---------ETRISDQGVGIPKESLEKIFERfyrvDKARSRQ 558
Cdd:cd16932 3 DQIRLQQVLADFLLNAVRFTPsPGGWVEIKVSPTKKQIgdgvhvihlEFRITHPGQGLPEELVQEMFEE----NQWTTQE 78
|
90
....*....|....*.
gi 518998827 559 lggtGLGLAIAKELVE 574
Cdd:cd16932 79 ----GLGLSISRKLVK 90
|
|
| PRK09776 |
PRK09776 |
putative diguanylate cyclase; Provisional |
261-409 |
2.33e-06 |
|
putative diguanylate cyclase; Provisional
Pssm-ID: 182070 [Multi-domain] Cd Length: 1092 Bit Score: 50.83 E-value: 2.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 261 EKRKLSSVLANMSDGVISTDRKGRIILINESAEKMLNISRDDVISKPLLAVLGIEDQYSVEDLFNEQGSLVldygTKTKP 340
Cdd:PRK09776 534 EKERLHITLDSIGEAVVCTDMAMKVTFMNPVAEKMTGWTQEEALGVPLLTVLHITFGDNGPLMENIYSCLT----SRSAA 609
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 341 LI-------------FRANYST--IQKETGKVNGLIVVLHDITEQEKIEmerREFVYNVSHELRTPLTTMKSYLEALSEg 405
Cdd:PRK09776 610 YLeqdvvlhcrsggsYDVHYSItpLSTLDGENIGSVLVIQDVTESRKML---RQLSYSASHDALTHLANRASFEKQLRR- 685
|
....
gi 518998827 406 ALQD 409
Cdd:PRK09776 686 LLQT 689
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
501-602 |
9.47e-05 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 45.28 E-value: 9.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 501 ISNAIKY---SPDGGQVTFKVVLFQNYIETRISDQGVGIPKEslekiferfyrVDKARSRqlggtGLGLAIAKELVEAHG 577
Cdd:COG3920 408 VTNALKHaflSGEGGRIRVSWRREDGRLRLTVSDNGVGLPED-----------VDPPARK-----GLGLRLIRALVRQLG 471
|
90 100
....*....|....*....|....*
gi 518998827 578 GKIwaTSAEGKGTTIHFTLPYDRDQ 602
Cdd:COG3920 472 GTL--ELDRPEGTRVRITFPLAELA 494
|
|
| sensory_box |
TIGR00229 |
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ... |
260-374 |
1.72e-04 |
|
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]
Pssm-ID: 272971 [Multi-domain] Cd Length: 124 Bit Score: 41.51 E-value: 1.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 260 SEKRkLSSVLANMSDGVISTDRKGRIILINESAEKMLNISRDDVISKPLLAVLGIED-QYSVEDLFNEQGSLVLDYGTKT 338
Cdd:TIGR00229 1 SEER-YRAIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRNVLELIPEEDrEEVRERIERRLEGEPEPVSEER 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 518998827 339 KplIFRANYSTIQKE--------TGKVNGLIVVLHDITEQEKIE 374
Cdd:TIGR00229 80 R--VRRKDGSEIWVEvsvspirtNGGELGVVGIVRDITERKEAE 121
|
|
| PAS_8 |
pfam13188 |
PAS domain; PAS domains are involved in many signalling proteins where they are used as a ... |
263-312 |
1.81e-04 |
|
PAS domain; PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. This domain recognizes oxygen and CO (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463802 [Multi-domain] Cd Length: 65 Bit Score: 39.84 E-value: 1.81e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 518998827 263 RKLSSVLANMSDGVISTDRKGRIILINESAEKMLNISRDDVISKPLLAVL 312
Cdd:pfam13188 1 ERLRALFESSPDGILVLDEGGRIIYVNPAALELLGYELLGELLGELLDLL 50
|
|
| HATPase_PDK-like |
cd16929 |
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ... |
528-597 |
2.84e-04 |
|
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.
Pssm-ID: 340406 [Multi-domain] Cd Length: 169 Bit Score: 41.94 E-value: 2.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 528 RISDQGVGIPKESLEKIFERFY----------RVDKARSRQ---LGGTGLGLAIAKELVEAHGGKIWATSAEGKGTTIHF 594
Cdd:cd16929 87 KISDRGGGIPREDLARLFSYMYstapqpslddFSDLISGTQpspLAGFGYGLPMSRLYAEYFGGDLDLQSMEGYGTDVYI 166
|
...
gi 518998827 595 TLP 597
Cdd:cd16929 167 YLK 169
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
495-597 |
4.60e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 40.10 E-value: 4.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 495 QVL-DNIISNAIKYSPDGGQVTFKVVLFQNYIETRISDQGVGIPKESLEKIFERFYRVDKarsrqlgGTGLGLA-IAKEL 572
Cdd:cd16957 7 QVLvENAIRHAFPKRKENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGKTTVTSEK-------GTGTALEnLNRRL 79
|
90 100
....*....|....*....|....*..
gi 518998827 573 VEAHG--GKIWATSAEGKGTTIHFTLP 597
Cdd:cd16957 80 IGLFGseACLHIESEVHGGTEVWFVIP 106
|
|
| HATPase_EL346-LOV-HK-like |
cd16951 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
488-597 |
8.19e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.
Pssm-ID: 340427 [Multi-domain] Cd Length: 131 Bit Score: 39.71 E-value: 8.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 488 VDADKMTQ---VLDNIISNAIKYS---PDGGQVTFKVVLFQNYIETRISDQGVGIPKESlekiferfyrvDKARSrqlgg 561
Cdd:cd16951 32 VSSEVATAiglVVNELLQNALKHAfsdREGGTITIRSVVDGDYLRITVIDDGVGLPQDE-----------DWPNK----- 95
|
90 100 110
....*....|....*....|....*....|....*.
gi 518998827 562 TGLGLAIAKELVEAHGGKIWATSAEGKGTTIHFTLP 597
Cdd:cd16951 96 GSLGLQIVRSLVEGELKAFLEVQSAENGTRVNIDIP 131
|
|
| PRK11388 |
PRK11388 |
DNA-binding transcriptional regulator DhaR; Provisional |
236-312 |
1.95e-03 |
|
DNA-binding transcriptional regulator DhaR; Provisional
Pssm-ID: 183114 [Multi-domain] Cd Length: 638 Bit Score: 41.20 E-value: 1.95e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518998827 236 EIGQLAQTfnyltkklQEEQAKTESEKRKLSSVLANMSDGVISTDRKGRIILINESAEKMLNISRDDVISKPLLAVL 312
Cdd:PRK11388 184 EVGNLLLT--------DSLLAESNRHLNQLNALLESMDDGVIAWDEQGNLQFLNAQAARLLRLDATASQGRAITELL 252
|
|
| PRK10935 |
PRK10935 |
nitrate/nitrite two-component system sensor histidine kinase NarQ; |
189-266 |
2.38e-03 |
|
nitrate/nitrite two-component system sensor histidine kinase NarQ;
Pssm-ID: 236800 [Multi-domain] Cd Length: 565 Bit Score: 40.99 E-value: 2.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518998827 189 VIASGITAILAI---------FVAQTITRPLSDMRSQAQAMAKGNFSR-KVKVYSQDEIGQLAQTFNYLTKKLQ------ 252
Cdd:PRK10935 150 LAAISLLGLILIltlvfftvrFTRRQVVAPLNQLVTASQQIEKGQFDHiPLDTTLPNELGLLAKAFNQMSSELHklyrsl 229
|
90
....*....|....*
gi 518998827 253 EEQAKtesEK-RKLS 266
Cdd:PRK10935 230 EASVE---EKtRKLT 241
|
|
| |
