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Conserved domains on  [gi|518932428|ref|WP_020088303|]
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acetate/propionate family kinase [Levilactobacillus parabrevis]

Protein Classification

acetate/propionate family kinase( domain architecture ID 10000961)

acetate/propionate family kinase such as acetate kinase that catalyzes the production of acetyl-CoA by phosphorylating acetate in the presence of ATP; may act on propionate and/or other substrates as well

CATH:  3.30.420.40
EC:  2.7.2.-
Gene Ontology:  GO:0016774|GO:0016310|GO:0000287|GO:0005524|GO:0006082|GO:0016301
PubMed:  7883769|23031654|16678422|9484901

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AckA COG0282
Acetate kinase [Energy production and conversion];
5-394 0e+00

Acetate kinase [Energy production and conversion];


:

Pssm-ID: 440051  Cd Length: 395  Bit Score: 648.64  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428   5 LAINAGSSTLKFKLFQMPEESVIAEGAIDRIGLGNSLVEIKYGDGEKYKTTQDVNDHKEAIQLMLDQLTKLEIITDFNEI 84
Cdd:COG0282    4 LVLNAGSSSLKFQLFDMDSEEVLAKGLVERIGLPGARLKHKDAGGEKVERELPIPDHAAALALVLELLTDHGIIKDLDEI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428  85 TGIGHRVVAGGEEFKDSAVIDDDVLQKIKDLAEYAPLHNPAAAMGIEAFKKILPNVLSVAVFDTSFHTSMPEVNYMYAIP 164
Cdd:COG0282   84 DAVGHRVVHGGEKFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEVAYLYALP 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428 165 YEYYEKFGARKYGAHGTSHRYVANRAAAMLGKPLKDLKLITMHIGAGGSITAIKDGKSYDTSMGFTPLAGIEMATRSGDI 244
Cdd:COG0282  164 YELYEKYGIRRYGFHGTSHRYVAERAAELLGKPLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVMGTRSGDI 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428 245 DASLVAYLMEKLNIDkPSDMINILNKKSGLVGVSGVSADMRELE-AVQDKNHRAKLARDMFINRIVRYVGAYLAELGGAD 323
Cdd:COG0282  244 DPGVVLYLMRKEGLS-ADEVDDLLNKESGLLGLSGISSDMRDLEeAAASGDERARLALDMFVYRIKKYIGAYAAALGGLD 322

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 518932428 324 AIVFTAGVGENDIMIRQEVADKLTYFGIGVDPEKNNIRGVERDLSVAGSKIKTLLIPTDEELMIVRDIERL 394
Cdd:COG0282  323 ALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANAARGGERVISTPDSRVKVLVIPTNEELMIARDTLRL 393
 
Name Accession Description Interval E-value
AckA COG0282
Acetate kinase [Energy production and conversion];
5-394 0e+00

Acetate kinase [Energy production and conversion];


Pssm-ID: 440051  Cd Length: 395  Bit Score: 648.64  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428   5 LAINAGSSTLKFKLFQMPEESVIAEGAIDRIGLGNSLVEIKYGDGEKYKTTQDVNDHKEAIQLMLDQLTKLEIITDFNEI 84
Cdd:COG0282    4 LVLNAGSSSLKFQLFDMDSEEVLAKGLVERIGLPGARLKHKDAGGEKVERELPIPDHAAALALVLELLTDHGIIKDLDEI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428  85 TGIGHRVVAGGEEFKDSAVIDDDVLQKIKDLAEYAPLHNPAAAMGIEAFKKILPNVLSVAVFDTSFHTSMPEVNYMYAIP 164
Cdd:COG0282   84 DAVGHRVVHGGEKFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEVAYLYALP 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428 165 YEYYEKFGARKYGAHGTSHRYVANRAAAMLGKPLKDLKLITMHIGAGGSITAIKDGKSYDTSMGFTPLAGIEMATRSGDI 244
Cdd:COG0282  164 YELYEKYGIRRYGFHGTSHRYVAERAAELLGKPLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVMGTRSGDI 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428 245 DASLVAYLMEKLNIDkPSDMINILNKKSGLVGVSGVSADMRELE-AVQDKNHRAKLARDMFINRIVRYVGAYLAELGGAD 323
Cdd:COG0282  244 DPGVVLYLMRKEGLS-ADEVDDLLNKESGLLGLSGISSDMRDLEeAAASGDERARLALDMFVYRIKKYIGAYAAALGGLD 322

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 518932428 324 AIVFTAGVGENDIMIRQEVADKLTYFGIGVDPEKNNIRGVERDLSVAGSKIKTLLIPTDEELMIVRDIERL 394
Cdd:COG0282  323 ALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANAARGGERVISTPDSRVKVLVIPTNEELMIARDTLRL 393
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 5-394 0e+00

acetate kinase A/propionate kinase 2; Reviewed


Pssm-ID: 234680  Cd Length: 402  Bit Score: 643.70  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428   5 LAINAGSSTLKFKLFQMPEESVIAEGAIDRIGLGNSLVEIKYGDGEKYKTTQDVNDHKEAIQLMLDQLT--KLEIITDFN 82
Cdd:PRK00180   4 LVLNAGSSSLKFQLIDMPNEEVLASGLVERIGLPDSRIKIKVDGGEKEEEELPIPDHAEALKFLLNTLTdgKLGLIKDLD 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428  83 EITGIGHRVVAGGEEFKDSAVIDDDVLQKIKDLAEYAPLHNPAAAMGIEAFKKILPNVLSVAVFDTSFHTSMPEVNYMYA 162
Cdd:PRK00180  84 EITAVGHRVVHGGEKFTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAFHQTMPEEAYLYA 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428 163 IPYEYYEKFGARKYGAHGTSHRYVANRAAAMLGKPLKDLKLITMHIGAGGSITAIKDGKSYDTSMGFTPLAGIEMATRSG 242
Cdd:PRK00180 164 LPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGKPLEELNLITCHLGNGASIAAIKNGKSVDTSMGFTPLEGLVMGTRSG 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428 243 DIDASLVAYLMEKLNIDkPSDMINILNKKSGLVGVSGVSADMRELE-AVQDKNHRAKLARDMFINRIVRYVGAYLAEL-G 320
Cdd:PRK00180 244 DIDPAIIPYLMEKLGMS-VDEIDNLLNKKSGLLGLSGVSSDMRDIEaAAEEGDERAKLALDVFVYRLAKYIGSYAAALnG 322

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518932428 321 GADAIVFTAGVGENDIMIRQEVADKLTYFGIGVDPEKNN--IRGVERDLSVAGSKIKTLLIPTDEELMIVRDIERL 394
Cdd:PRK00180 323 RLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNLaaRFGKEGDISTPDSKVKVLVIPTNEELMIARDTLRL 398
ASKHA_NBD_AcK_PK cd24010
nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain ...
 5-394 0e+00

nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain family; The family corresponds to a group of proteins which transfer phosphate from ATP to a short chain aliphatic acid. It includes acetate kinase (AckA) and propionate kinase (TdcD and PduW). Acetate kinase (EC 2.7.2.1), also called acetokinase, catalyzes the formation of acetyl phosphate from acetate and ATP. It can also catalyze the reverse reaction in the presence of a divalent cation. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically. Propionate kinase TdcD (EC 2.7.2.15) catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor. The family also includes propionate kinase PduW (EC 2.7.2.15) that works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD). This protein restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions. The AcK/PK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466860  Cd Length: 392  Bit Score: 601.80  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428   5 LAINAGSSTLKFKLFQMPEESVIAEGAIDRIGLGNSLVEIKYGDGEKYKTTQDVNDHKEAIQLMLDQLTKLEIITDFNEI 84
Cdd:cd24010    2 LVINCGSSSLKFQLFDMPTEEVLASGLVERIGLEGARLKHKVNNGEKIKEELPIPDHEEALKAILDTLTDPELGVSLDEI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428  85 TGIGHRVVAGGEEFKDSAVIDDDVLQKIKDLAEYAPLHNPAAAMGIEAFKKILPNVLSVAVFDTSFHTSMPEVNYMYAIP 164
Cdd:cd24010   82 DAVGHRVVHGGEKFTESVLIDDEVIAAIEDLSPLAPLHNPANLAGIEAARKLLPDVPQVAVFDTAFHQTMPPHAYLYALP 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428 165 YEYYEKFGARKYGAHGTSHRYVANRAAAMLGKPLKDLKLITMHIGAGGSITAIKDGKSYDTSMGFTPLAGIEMATRSGDI 244
Cdd:cd24010  162 YELYEKYGIRRYGFHGTSHRYVSRRAAELLGKPLEDLNLITCHLGNGASICAIKNGKSVDTSMGLTPLEGLVMGTRSGDI 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428 245 DASLVAYLMEKLNIDkPSDMINILNKKSGLVGVSGVSADMRELE-AVQDKNHRAKLARDMFINRIVRYVGAYLAELGGAD 323
Cdd:cd24010  242 DPAIVFYLMKKEGMS-VDEIERLLNKKSGLLGISGVSSDMRDIEeAAEEGDERAKLALDVFVYRIKKYIGAYAAALGGVD 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518932428 324 AIVFTAGVGENDIMIRQEVADKLTYFGIGVDPEKNNIR-GVERDLSVAGSKIKTLLIPTDEELMIVRDIERL 394
Cdd:cd24010  321 AIVFTGGIGENSALIRELVCEGLEFLGIELDEEKNKAAgGGEREISTPDSKVKVLVIPTNEELMIARDTVRL 392
Acetate_kinase pfam00871
Acetokinase family; This family includes acetate kinase, butyrate kinase and ...
 3-389 2.10e-175

Acetokinase family; This family includes acetate kinase, butyrate kinase and 2-methylpropanoate kinase.


Pssm-ID: 395700  Cd Length: 387  Bit Score: 493.86  E-value: 2.10e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428    3 KSLAINAGSSTLKFKLFQMPEESVIAEGAIDRIGLGNSLVEIKYGDGEKYKTTQDVNDHKEAIQLMLDQLTKLEIITDFN 82
Cdd:pfam00871   1 KVLVLNAGSSSIKFQLFDAVIGEVLLSGLAERIGLPNARILWKMNGGKKNAALLAGADHSEALNFILNTLLKHKIIELLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428   83 EITGIGHRVVAGGEEFKDSAVIDDDVLQKIKDLAEYAPLHNPAAAMGIEAFKKILPNVLSVAVFDTSFHTSMPEVNYMYA 162
Cdd:pfam00871  81 EITLIGHRVVHGGEKFTESVLITDEVIQGIKDLIPLAPLHNPAHLDGIEEAFKLFPQVKNVAVFDTAFHQTMPEEAYLYA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428  163 IPYEYYEKFGARKYGAHGTSHRYVANRAAAMLGKPLKDLKLITMHIGAGGSITAIKDGKSYDTSMGFTPLAGIEMATRSG 242
Cdd:pfam00871 161 LPYSWYKEHGIRRYGFHGTSHKYVSQRAAKILNKPLEDLNLITCHLGNGASVCAVRNGKSVDTSMGFTPLEGLVMGTRSG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428  243 DIDASLVAYLMEKLNIdKPSDMINILNKKSGLVGVSGVSADMRELEAVQDKNH-RAKLARDMFINRIVRYVGAYLAELGG 321
Cdd:pfam00871 241 DIDPAIIFYLAETLGM-SADEINNTLNKKSGLLGLSGVSSDLRYVEDAYAEGKeDAQLAIKVYVHRLAKYIGSYAASLER 319

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 518932428  322 ADAIVFTAGVGENDIMIRQEVADKLTYFGIGVDPEKNNIRGVERDLSVAGSKIKTLLIPTDEELMIVR 389
Cdd:pfam00871 320 LDAIVFTGGIGENAAMVRELVLNALEVLGFEIDPERNNRFGKSGVISTEDSRVKVVVIPTNEELMIAQ 387
ackA TIGR00016
acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in ...
 1-394 7.49e-173

acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate. Some members of this family have been shown to act on propionate as well as acetate. An example of a propionate/acetate kinase is TdcD of E. coli (SP|P11868), an enzyme of an anaerobic pathway of threonine catabolism. It is not known how many members of this family act on additional substrates besides acetate. [Energy metabolism, Fermentation]


Pssm-ID: 272856  Cd Length: 404  Bit Score: 488.08  E-value: 7.49e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428    1 MGKSLAINAGSSTLKFKLFQMP-EESVIAEGAIDRIGLGNSLVEIKYGDGEKYKTTQDVNDHKEAIQLMLDQLTKLEIIT 79
Cdd:TIGR00016   3 SMKILVLNAGSSSLKFALFDAVnGEEVLASGLAERIFLPNARIKWVEDGGKKEAELLAGADHQEALKFILNTLLKDKIIK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428   80 DFNEITGIGHRVVAGGEEFKDSAVIDDDVLQKIKDLAEYAPLHNPAAAMGIEAFK--KILPNVLSVAVFDTSFHTSMPEV 157
Cdd:TIGR00016  83 LLSEIDLIGHRVVHGGEKFTDSVIITDEVIQKIKDISPLAPLHNPAHLIGIEAALklFPLPKAKNVAVFDTAFHQTMPEE 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428  158 NYMYAIPYEYYEKFGARKYGAHGTSHRYVANRAAAMLGKPLKDLKLITMHIGAGGSITAIKDGKSYDTSMGFTPLAGIEM 237
Cdd:TIGR00016 163 AYLYALPYSWYKEHGVRRYGFHGTSHKYVTQRAAKILNKPLDDLNLIVCHLGNGASVCAIKNGKSIDTSMGFTPLEGLMM 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428  238 ATRSGDIDASLVAYLMEKLNIdKPSDMINILNKKSGLVGVSGVSADMRELE-AVQDKNHRAKLARDMFINRIVRYVGAYL 316
Cdd:TIGR00016 243 GTRSGDIDPAIIFYLAETLGM-SADDIENTLNKKSGLLGISGLSSDLRDIEdAYAEGNEQAKLAIKVYVHRIAKYIGSYI 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428  317 AELGGA-DAIVFTAGVGENDIMIRQEVADKLTYFGIGVDPEKNNI--RGVERDLSVAGSKIKTLLIPTDEELMIVRDIER 393
Cdd:TIGR00016 322 ASLEGNlDAIVFTGGIGENAAMVRELVLEKLEVLGFELDPELNNAarSGKSGVISTPESKVKILVIPTNEELMIAQDAIR 401


                  .
gi 518932428  394 L 394
Cdd:TIGR00016 402 L 402
 
Name Accession Description Interval E-value
AckA COG0282
Acetate kinase [Energy production and conversion];
5-394 0e+00

Acetate kinase [Energy production and conversion];


Pssm-ID: 440051  Cd Length: 395  Bit Score: 648.64  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428   5 LAINAGSSTLKFKLFQMPEESVIAEGAIDRIGLGNSLVEIKYGDGEKYKTTQDVNDHKEAIQLMLDQLTKLEIITDFNEI 84
Cdd:COG0282    4 LVLNAGSSSLKFQLFDMDSEEVLAKGLVERIGLPGARLKHKDAGGEKVERELPIPDHAAALALVLELLTDHGIIKDLDEI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428  85 TGIGHRVVAGGEEFKDSAVIDDDVLQKIKDLAEYAPLHNPAAAMGIEAFKKILPNVLSVAVFDTSFHTSMPEVNYMYAIP 164
Cdd:COG0282   84 DAVGHRVVHGGEKFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEVAYLYALP 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428 165 YEYYEKFGARKYGAHGTSHRYVANRAAAMLGKPLKDLKLITMHIGAGGSITAIKDGKSYDTSMGFTPLAGIEMATRSGDI 244
Cdd:COG0282  164 YELYEKYGIRRYGFHGTSHRYVAERAAELLGKPLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVMGTRSGDI 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428 245 DASLVAYLMEKLNIDkPSDMINILNKKSGLVGVSGVSADMRELE-AVQDKNHRAKLARDMFINRIVRYVGAYLAELGGAD 323
Cdd:COG0282  244 DPGVVLYLMRKEGLS-ADEVDDLLNKESGLLGLSGISSDMRDLEeAAASGDERARLALDMFVYRIKKYIGAYAAALGGLD 322

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 518932428 324 AIVFTAGVGENDIMIRQEVADKLTYFGIGVDPEKNNIRGVERDLSVAGSKIKTLLIPTDEELMIVRDIERL 394
Cdd:COG0282  323 ALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANAARGGERVISTPDSRVKVLVIPTNEELMIARDTLRL 393
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 5-394 0e+00

acetate kinase A/propionate kinase 2; Reviewed


Pssm-ID: 234680  Cd Length: 402  Bit Score: 643.70  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428   5 LAINAGSSTLKFKLFQMPEESVIAEGAIDRIGLGNSLVEIKYGDGEKYKTTQDVNDHKEAIQLMLDQLT--KLEIITDFN 82
Cdd:PRK00180   4 LVLNAGSSSLKFQLIDMPNEEVLASGLVERIGLPDSRIKIKVDGGEKEEEELPIPDHAEALKFLLNTLTdgKLGLIKDLD 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428  83 EITGIGHRVVAGGEEFKDSAVIDDDVLQKIKDLAEYAPLHNPAAAMGIEAFKKILPNVLSVAVFDTSFHTSMPEVNYMYA 162
Cdd:PRK00180  84 EITAVGHRVVHGGEKFTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAFHQTMPEEAYLYA 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428 163 IPYEYYEKFGARKYGAHGTSHRYVANRAAAMLGKPLKDLKLITMHIGAGGSITAIKDGKSYDTSMGFTPLAGIEMATRSG 242
Cdd:PRK00180 164 LPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGKPLEELNLITCHLGNGASIAAIKNGKSVDTSMGFTPLEGLVMGTRSG 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428 243 DIDASLVAYLMEKLNIDkPSDMINILNKKSGLVGVSGVSADMRELE-AVQDKNHRAKLARDMFINRIVRYVGAYLAEL-G 320
Cdd:PRK00180 244 DIDPAIIPYLMEKLGMS-VDEIDNLLNKKSGLLGLSGVSSDMRDIEaAAEEGDERAKLALDVFVYRLAKYIGSYAAALnG 322

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518932428 321 GADAIVFTAGVGENDIMIRQEVADKLTYFGIGVDPEKNN--IRGVERDLSVAGSKIKTLLIPTDEELMIVRDIERL 394
Cdd:PRK00180 323 RLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNLaaRFGKEGDISTPDSKVKVLVIPTNEELMIARDTLRL 398
ASKHA_NBD_AcK_PK cd24010
nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain ...
 5-394 0e+00

nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain family; The family corresponds to a group of proteins which transfer phosphate from ATP to a short chain aliphatic acid. It includes acetate kinase (AckA) and propionate kinase (TdcD and PduW). Acetate kinase (EC 2.7.2.1), also called acetokinase, catalyzes the formation of acetyl phosphate from acetate and ATP. It can also catalyze the reverse reaction in the presence of a divalent cation. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically. Propionate kinase TdcD (EC 2.7.2.15) catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor. The family also includes propionate kinase PduW (EC 2.7.2.15) that works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD). This protein restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions. The AcK/PK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466860  Cd Length: 392  Bit Score: 601.80  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428   5 LAINAGSSTLKFKLFQMPEESVIAEGAIDRIGLGNSLVEIKYGDGEKYKTTQDVNDHKEAIQLMLDQLTKLEIITDFNEI 84
Cdd:cd24010    2 LVINCGSSSLKFQLFDMPTEEVLASGLVERIGLEGARLKHKVNNGEKIKEELPIPDHEEALKAILDTLTDPELGVSLDEI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428  85 TGIGHRVVAGGEEFKDSAVIDDDVLQKIKDLAEYAPLHNPAAAMGIEAFKKILPNVLSVAVFDTSFHTSMPEVNYMYAIP 164
Cdd:cd24010   82 DAVGHRVVHGGEKFTESVLIDDEVIAAIEDLSPLAPLHNPANLAGIEAARKLLPDVPQVAVFDTAFHQTMPPHAYLYALP 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428 165 YEYYEKFGARKYGAHGTSHRYVANRAAAMLGKPLKDLKLITMHIGAGGSITAIKDGKSYDTSMGFTPLAGIEMATRSGDI 244
Cdd:cd24010  162 YELYEKYGIRRYGFHGTSHRYVSRRAAELLGKPLEDLNLITCHLGNGASICAIKNGKSVDTSMGLTPLEGLVMGTRSGDI 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428 245 DASLVAYLMEKLNIDkPSDMINILNKKSGLVGVSGVSADMRELE-AVQDKNHRAKLARDMFINRIVRYVGAYLAELGGAD 323
Cdd:cd24010  242 DPAIVFYLMKKEGMS-VDEIERLLNKKSGLLGISGVSSDMRDIEeAAEEGDERAKLALDVFVYRIKKYIGAYAAALGGVD 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518932428 324 AIVFTAGVGENDIMIRQEVADKLTYFGIGVDPEKNNIR-GVERDLSVAGSKIKTLLIPTDEELMIVRDIERL 394
Cdd:cd24010  321 AIVFTGGIGENSALIRELVCEGLEFLGIELDEEKNKAAgGGEREISTPDSKVKVLVIPTNEELMIARDTVRL 392
Acetate_kinase pfam00871
Acetokinase family; This family includes acetate kinase, butyrate kinase and ...
 3-389 2.10e-175

Acetokinase family; This family includes acetate kinase, butyrate kinase and 2-methylpropanoate kinase.


Pssm-ID: 395700  Cd Length: 387  Bit Score: 493.86  E-value: 2.10e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428    3 KSLAINAGSSTLKFKLFQMPEESVIAEGAIDRIGLGNSLVEIKYGDGEKYKTTQDVNDHKEAIQLMLDQLTKLEIITDFN 82
Cdd:pfam00871   1 KVLVLNAGSSSIKFQLFDAVIGEVLLSGLAERIGLPNARILWKMNGGKKNAALLAGADHSEALNFILNTLLKHKIIELLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428   83 EITGIGHRVVAGGEEFKDSAVIDDDVLQKIKDLAEYAPLHNPAAAMGIEAFKKILPNVLSVAVFDTSFHTSMPEVNYMYA 162
Cdd:pfam00871  81 EITLIGHRVVHGGEKFTESVLITDEVIQGIKDLIPLAPLHNPAHLDGIEEAFKLFPQVKNVAVFDTAFHQTMPEEAYLYA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428  163 IPYEYYEKFGARKYGAHGTSHRYVANRAAAMLGKPLKDLKLITMHIGAGGSITAIKDGKSYDTSMGFTPLAGIEMATRSG 242
Cdd:pfam00871 161 LPYSWYKEHGIRRYGFHGTSHKYVSQRAAKILNKPLEDLNLITCHLGNGASVCAVRNGKSVDTSMGFTPLEGLVMGTRSG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428  243 DIDASLVAYLMEKLNIdKPSDMINILNKKSGLVGVSGVSADMRELEAVQDKNH-RAKLARDMFINRIVRYVGAYLAELGG 321
Cdd:pfam00871 241 DIDPAIIFYLAETLGM-SADEINNTLNKKSGLLGLSGVSSDLRYVEDAYAEGKeDAQLAIKVYVHRLAKYIGSYAASLER 319

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 518932428  322 ADAIVFTAGVGENDIMIRQEVADKLTYFGIGVDPEKNNIRGVERDLSVAGSKIKTLLIPTDEELMIVR 389
Cdd:pfam00871 320 LDAIVFTGGIGENAAMVRELVLNALEVLGFEIDPERNNRFGKSGVISTEDSRVKVVVIPTNEELMIAQ 387
ackA TIGR00016
acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in ...
 1-394 7.49e-173

acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate. Some members of this family have been shown to act on propionate as well as acetate. An example of a propionate/acetate kinase is TdcD of E. coli (SP|P11868), an enzyme of an anaerobic pathway of threonine catabolism. It is not known how many members of this family act on additional substrates besides acetate. [Energy metabolism, Fermentation]


Pssm-ID: 272856  Cd Length: 404  Bit Score: 488.08  E-value: 7.49e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428    1 MGKSLAINAGSSTLKFKLFQMP-EESVIAEGAIDRIGLGNSLVEIKYGDGEKYKTTQDVNDHKEAIQLMLDQLTKLEIIT 79
Cdd:TIGR00016   3 SMKILVLNAGSSSLKFALFDAVnGEEVLASGLAERIFLPNARIKWVEDGGKKEAELLAGADHQEALKFILNTLLKDKIIK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428   80 DFNEITGIGHRVVAGGEEFKDSAVIDDDVLQKIKDLAEYAPLHNPAAAMGIEAFK--KILPNVLSVAVFDTSFHTSMPEV 157
Cdd:TIGR00016  83 LLSEIDLIGHRVVHGGEKFTDSVIITDEVIQKIKDISPLAPLHNPAHLIGIEAALklFPLPKAKNVAVFDTAFHQTMPEE 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428  158 NYMYAIPYEYYEKFGARKYGAHGTSHRYVANRAAAMLGKPLKDLKLITMHIGAGGSITAIKDGKSYDTSMGFTPLAGIEM 237
Cdd:TIGR00016 163 AYLYALPYSWYKEHGVRRYGFHGTSHKYVTQRAAKILNKPLDDLNLIVCHLGNGASVCAIKNGKSIDTSMGFTPLEGLMM 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428  238 ATRSGDIDASLVAYLMEKLNIdKPSDMINILNKKSGLVGVSGVSADMRELE-AVQDKNHRAKLARDMFINRIVRYVGAYL 316
Cdd:TIGR00016 243 GTRSGDIDPAIIFYLAETLGM-SADDIENTLNKKSGLLGISGLSSDLRDIEdAYAEGNEQAKLAIKVYVHRIAKYIGSYI 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428  317 AELGGA-DAIVFTAGVGENDIMIRQEVADKLTYFGIGVDPEKNNI--RGVERDLSVAGSKIKTLLIPTDEELMIVRDIER 393
Cdd:TIGR00016 322 ASLEGNlDAIVFTGGIGENAAMVRELVLEKLEVLGFELDPELNNAarSGKSGVISTPESKVKILVIPTNEELMIAQDAIR 401


                  .
gi 518932428  394 L 394
Cdd:TIGR00016 402 L 402
PRK12397 PRK12397
acetate/propionate family kinase;
2-394 1.80e-153

acetate/propionate family kinase;


Pssm-ID: 183500  Cd Length: 404  Bit Score: 439.28  E-value: 1.80e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428   2 GKSLAINAGSSTLKFKLFQMPEESVIAEGAIDRIGLGNSLVEIKYGDgEKYKTTQDVNDHKEAIQLMLDQLTKLEIITDF 81
Cdd:PRK12397   3 YKIMAINAGSSSLKFQLLEMPQGDMLCQGLIERIGMADAQVTIKTHS-QKWQETVPVADHRDAVTLLLEKLLGYQIINSL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428  82 NEITGIGHRVVAGGEEFKDSAVIDDDVLQKIKDLAEYAPLHNPAAAMGIEAFKKILPNVLSVAVFDTSFHTSMPEVNYMY 161
Cdd:PRK12397  82 RDIDGVGHRVAHGGEFFKDSTLVTDETLAQIERLAELAPLHNPVNALGIHVFRQLLPDAPSVAVFDTAFHQTLDEPAYIY 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428 162 AIPYEYYEKFGARKYGAHGTSHRYVANRAAAMLGKPLKDLKLITMHIGAGGSITAIKDGKSYDTSMGFTPLAGIEMATRS 241
Cdd:PRK12397 162 PLPWRYYAELGIRRYGFHGTSHKYVSGVLAEKLGVPLSALRVICCHLGNGSSICAIKNGRSVNTSMGFTPQSGVMMGTRS 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428 242 GDIDASLVAYLMEKLNidKPSDMIN-ILNKKSGLVGVSGVSADMRELE-AVQDKNHRAKLARDMFINRIVRYVGAYLAEL 319
Cdd:PRK12397 242 GDIDPSILPWIAQREG--KTPQQLNqLLNNESGLLGVSGVSSDYRDVEqAANTGNRQAKLALTLFAERIRATIGSYIMQM 319

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518932428 320 GGADAIVFTAGVGENDIMIRQEVADKLTYFGIGVDPEKN--NIRGVERDLSVagskIKTLLIPTDEELMIVRDIERL 394
Cdd:PRK12397 320 GGLDALVFTGGIGENSARARSAVCHNLQFLGLAVDEEKNqrNATFIQTENAL----VKVAVINTNEELMIAQDVMRI 392
PRK07157 PRK07157
acetate kinase; Provisional
 1-394 1.52e-140

acetate kinase; Provisional


Pssm-ID: 235948  Cd Length: 400  Bit Score: 406.05  E-value: 1.52e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428   1 MGKSLAINAGSSTLKFKLFQMPEESVIAEGAIDRIGLGNSLVEIKYGdGEKYKTTQDVNDHKEAIQLMLDQLTKLEIITD 80
Cdd:PRK07157   2 KAKILVINAGSSSIKWQLFDKENLNLIASGLAERIGLENGLIKIKFG-KKKYEKEVDMPNHKVAVAVLIEIWEENKLIED 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428  81 FNEITGIGHRVVAGGEEFKDSAVIDDDVLQKIKDLAEYAPLHNPAAAMGIEAFKKILPNVLSVAVFDTSFHTSMPEVNYM 160
Cdd:PRK07157  81 LEEIELIGFRVVHGGDYFNGPTKLDDKEISKIEKVAKYAPLHNPGALQTIKAFKKVLPKAKLSASFDTAFHTSIPKINYT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428 161 YAIPYEYYEKFGARKYGAHGTSHRYVANRAAAMLGKplKDLKLITMHIGAGGSITAIKDGKSYDTSMGFTPLAGIEMATR 240
Cdd:PRK07157 161 YPINYEIAKKYGIKKYGFHGISHKFITNKVEKILNK--DKVNFVNLHIGNGASLCAIKNSKSIDTSMGLTPLAGVMMGTR 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428 241 SGDIDASLVAYLMEKLNIDKpSDMINILNKKSGLVGVSGVSADMREL-EAVQDKNHRAKLARDMFINRIVRYVGAYLAEL 319
Cdd:PRK07157 239 SGDIDPSIHEFVAKEANMSI-SEFTDLLNKKSGLLGVSGISSDLRDViKAAESGNKRAKFALDLYAQKIVDYLANYINKI 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428 320 GGA-DAIVFTAGVGENDIMIRQEVADKLTYFGIGVDPEKNNIR----GVERDLSVAGSKIKTLLIPTDEELMIVRDIERL 394
Cdd:PRK07157 318 GKKiDAIVFTAGVGENSAFVRELVINKINIPNIKLDKEKNLKKigeyGPIELISTPDSDIPVYVIRTNEELLIAKNAIKL 397
PRK12379 PRK12379
propionate kinase;
5-396 2.17e-127

propionate kinase;


Pssm-ID: 183484  Cd Length: 396  Bit Score: 372.53  E-value: 2.17e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428   5 LAINAGSSTLKFKLFQMPEESVIAEGAIDRIGLGNSLVEIKygDGEKYKTTQdvNDHKEAIQLMLDQLTKLEIItdfNEI 84
Cdd:PRK12379   8 LVINCGSSSIKFSVLDASDCEVLMSGIADGINSENAFLSVN--GGEPAPLAH--HSYEGALKAIAFELEKRNLN---DSV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428  85 TGIGHRVVAGGEEFKDSAVIDDDVLQKIKDLAEYAPLHNPAAAMGIEAFKKILPNVLSVAVFDTSFHTSMPEVNYMYAIP 164
Cdd:PRK12379  81 ALIGHRIAHGGSIFTESVIITDEVIDNIRRVSPLAPLHNYANLSGIEAAQQLFPGVTQVAVFDTSFHQTLAPEAYLYGLP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428 165 YEYYEKFGARKYGAHGTSHRYVANRAAAMLGKPLKDLKLITMHIGAGGSITAIKDGKSYDTSMGFTPLAGIEMATRSGDI 244
Cdd:PRK12379 161 WEYYEELGVRRYGFHGTSHRYVSQRAHSLLNLDEDDSGLVVAHLGNGASICAVRNGQSVDTSMGMTPLEGLMMGTRSGDV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428 245 DASLVAYLMEKLNiDKPSDMINILNKKSGLVGVSGVSADMRELEAVQDKNH-RAKLARDMFINRIVRYVGAYLAELGGAD 323
Cdd:PRK12379 241 DFGAMAWIASQTG-QTLGDLERVVNKESGLLGISGLSSDLRVLEKAWHEGHeRAQLAIKTFVHRIARHIAGHAASLHRLD 319

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 518932428 324 AIVFTAGVGENDIMIRQEVADKLTYFGIGVDPEKNNI--RGVERDLSVAGSKIKTLLIPTDEELMIVRDIERLRK 396
Cdd:PRK12379 320 GIIFTGGIGENSSLIRRLVMEHLAVLGLEIDTEMNNQpnSGGERIISSENSRVICAVIPTNEEKMIALDAIHLGK 394
PRK12440 PRK12440
acetate/propionate family kinase;
5-389 7.36e-105

acetate/propionate family kinase;


Pssm-ID: 183528  Cd Length: 397  Bit Score: 314.88  E-value: 7.36e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428   5 LAINAGSSTLKFKLFQMPEESVIAEGAIDRIGLGNSLVEIKYgDGEKYK--TTQDVNDHKEAIQLMLDQLTKLEIITDfn 82
Cdd:PRK12440   7 LVINSGSSSLKFAVIDSVTGEAVLSGLGECFGLEDARMSWKY-QGEKTEiaIEGEDNHHKIAIGRLVGLTEELGFTQD-- 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428  83 eITGIGHRVVAGGEEFKDSAVIDDDVLQKIKDLAEYAPLHNPAAAMGIEAFKKILPNVLSVAVFDTSFHTSMPEVNYMYA 162
Cdd:PRK12440  84 -IVAVGHRIVHGGEKFTSTVRIDEEVTAEIESLSDLAPLHNPAGAIGIRAAMAAFPSLPQFAVFDTAFHQTMPKKAFTGA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428 163 IPYEYYEKFGARKYGAHGTSHRYVANRAAAMLGKPLKDLKLITMHIGAGGSITAIKDGKSYDTSMGFTPLAGIEMATRSG 242
Cdd:PRK12440 163 IAKELYTDFGIRRYGFHGTSHYFVSREAAKMLNKPIEESSFISVHLGNGASVCAIKNGQSVDTSMGFTPLSGLMMGTRCG 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428 243 DIDASLVAYLMEK-LNIDKpsdMINILNKKSGLVGVSGVSADMRE-LEAVQDKNHRAKLARDMFINRIVRYVGAYLAELG 320
Cdd:PRK12440 243 DLDPGIIEFLLKKgWSQEK---VFNSLNKKSGFLGVSGLTSDARGiLEAMEEGHEGATLAFEVFTYRVAKYIASYLAALD 319

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518932428 321 GADAIVFTAGVGENDIMIRQEVADKLTYFGIGVDPEKNNIRGVERDLSVAGSKI---KTLLIPTDEELMIVR 389
Cdd:PRK12440 320 SLDGIIFTGGIGENSLPIRREILKNLKLLGFVEDEKGNEDARFGKAGIIAKSELlnaVAMVIPTNEEFVIAQ 391
PRK07058 PRK07058
acetate/propionate family kinase;
5-390 2.57e-90

acetate/propionate family kinase;


Pssm-ID: 235922  Cd Length: 396  Bit Score: 277.70  E-value: 2.57e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428   5 LAINAGSSTLKFKLFQMPEESV--IAEGAID------RIGL--GNSLVEIKYgdgeKYKTTQDVNDhkeaiqlMLDQ-LT 73
Cdd:PRK07058   7 LTFNAGSSTVKIGLFEVDGNEArrIGKGDIDfrraplRFHLrnGGETLDIPL----KASVTDDLHT-------VLDEtFD 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428  74 KLEIITDFNEITGIGHRVVAGGEEFKDSAVIDDDVLQKIKDLAEYAPLHNPAAAMGIEAFKKILPNVLSVAVFDTSFHTS 153
Cdd:PRK07058  76 WLAAHFDVSELVAVGHRVVHGGDRFAGAVLIDDATLDAIEALVPLAPLHQPQSLRLIRAIRHLRPHLPQTASFDTAFHRT 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428 154 MPEVNYMYAIPYEYYEKfGARKYGAHGTSHRYVANRaAAMLGKPLKDLKLITMHIGAGGSITAIKDGKSYDTSMGFTPLA 233
Cdd:PRK07058 156 QPDLVRRFAIPRALHDE-GIKRYGFHGLSYKFVAGE-LRRRAPELARGKVVAAHLGSGASLCALDAGKSRDTSMGFSTLD 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428 234 GIEMATRSGDIDASLVAYLMEKLNIdKPSDMINILNKKSGLVGVSGVSADMRELEAvqDKNHRAKLARDMFINRIVRYVG 313
Cdd:PRK07058 234 GIPMATRCGALDPGVVLHLLKQEGM-SLDEVEDLLYHRSGLLGVSGISGDTRDLLA--SDAPEAREALDLFALRIAGEIA 310

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518932428 314 AYLAELGGADAIVFTAGVGENDIMIRQEVADKLTYFGIGVDPEKNNIRGveRDLSVAGSKIKTLLIPTDEELMIVRD 390
Cdd:PRK07058 311 RLAATLGGLDAVVFTAGIGEHQPAIRAAVCERLAWLGVELDPAANAANA--FTISSRTSRVAAFVIPTDEEQVIADE 385
ASKHA_NBD_BK cd24011
nucleotide-binding domain (NBD) of the butyrate kinase (BK) domain family; Butyrate kinase (EC ...
 174-350 3.29e-22

nucleotide-binding domain (NBD) of the butyrate kinase (BK) domain family; Butyrate kinase (EC 2.7.2.7) catalyzes the formation of butyryl-CoA by phosphorylating butyrate in the presence of ATP to form butyryl phosphate. Butyrate kinases exist in many fermentative species of the bacterial and archaeal families. They belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466861  Cd Length: 345  Bit Score: 96.45  E-value: 3.29e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428 174 RKYGAHGTSHRYVANRAAAMLGKPLKDLKLITMHIGAGGSITAIKDGKSYDTSMG------FTPlagiemaTRSGDIDAS 247
Cdd:cd24011  147 RRSIFHALNQKAVARRAAKELGKPYEELNLIVAHLGGGISVGAHRKGRVIDVNNAldgegpFSP-------ERAGTLPVG 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428 248 LVAYLMEKLNIDKPsDMINILNKKSGLVGVSGVSaDMRELEA-VQDKNHRAKLARDMFINRIVRYVGAYLAELGG-ADAI 325
Cdd:cd24011  220 DLIKLCFSGKYTLE-ELKKKLKGKGGLVAYLGTN-DFREVEKrIEAGDEKAKLVLDAMAYQIAKEIGALAAVLKGkVDAI 297

                        170       180
                 ....*....|....*....|....*
gi 518932428 326 VFTAGVGENDIMIrQEVADKLTYFG 350
Cdd:cd24011  298 ILTGGLAYSKRLV-DRIKERVGFIA 321
PRK03011 PRK03011
butyrate kinase; Provisional
 174-350 8.39e-18

butyrate kinase; Provisional


Pssm-ID: 235099  Cd Length: 358  Bit Score: 84.06  E-value: 8.39e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428 174 RKYGAHGTSHRYVANRAAAMLGKPLKDLKLITMHIGAGGSITAIKDGKSYDTSMG------FTPLagiematRSGDIDAS 247
Cdd:PRK03011 149 RKSIFHALNQKAVARRVAKELGKKYEELNLIVAHLGGGISVGAHRKGRVIDVNNAldgegpFSPE-------RAGGLPVG 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518932428 248 -LVAYLMEklNIDKPSDMINILNKKSGLVGVSGvSADMRELEA-VQDKNHRAKLARDMFINRIVRYVGAYLAELGG-ADA 324
Cdd:PRK03011 222 dLVELCFS--GKYTKEELKKKLVGKGGLVAYLG-TNDAREVEKrIEEGDEKAKLVYEAMAYQIAKEIGAMAAVLKGkVDA 298

                        170       180
                 ....*....|....*....|....*.
gi 518932428 325 IVFTAGVGENDIMIrQEVADKLTYFG 350
Cdd:PRK03011 299 IVLTGGLAYSKRLV-ERIKERVSFIA 323
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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