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Conserved domains on  [gi|518666629|ref|WP_019828330|]
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MULTISPECIES: TSUP family transporter [Pseudomonas]

Protein Classification

sulfite exporter TauE/SafE family protein( domain architecture ID 229451)

sulfite exporter TauE/SafE family protein is an inner membrane anion permease involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DsbD super family cl21514
Cytochrome C biogenesis protein transmembrane region; This family consists of the ...
5-258 2.44e-54

Cytochrome C biogenesis protein transmembrane region; This family consists of the transmembrane (i.e. non-catalytic) region of Cytochrome C biogenesis proteins also known as disulphide interchange proteins. These proteins posses a protein disulphide isomerase like domain that is not found within the aligned region of this family.


The actual alignment was detected with superfamily member PRK10621:

Pssm-ID: 473893  Cd Length: 266  Bit Score: 176.04  E-value: 2.44e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518666629   5 LSVDLTTLAILAAVAFVAGFIDAIAGGGGLLTTPALLTAGLPPHLVLGTNKLSSTFGAATASFTFYRRKLFHPREWKLAI 84
Cdd:PRK10621   5 FMVSPLLLGVLFFVAMLAGFIDSIAGGGGLLTIPALLAAGMSPAQALATNKLQACGGSFSASLYFIRRKVVNLADQKLNI 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518666629  85 FGTLAGALIGAVVAHYMPAEWLNKMLPVIVFGCGIYLLFggTPKtpIDNDAPIKKKWQLP----QGFGLGFYDGVAGPGT 160
Cdd:PRK10621  85 AMTFVGSMSGALLVQYVQADILRQILPILVIGIGLYFLL--MPK--LGEEDRQRRLYGLPfaliAGGCVGFYDGFFGPGA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518666629 161 GAFWTVSTMLMYPVDLVKASGVARSMNFVSNIAALSVFIFSGHVDWVIGLTMGFAVMIGAFFGARSAISGGAKFIRPVFI 240
Cdd:PRK10621 161 GSFYALAFVTLCGFNLAKATAHAKVLNATSNIGGLLLFILGGKVIWATGFVMLVGQFLGARLGARLVLSKGQKLIRPMIV 240
                        250       260
                 ....*....|....*....|....*
gi 518666629 241 TVVLGLTVRLAW-------QHWFGM 258
Cdd:PRK10621 241 IVSAVMSAKLLYdshgqeiLHWLGM 265
 
Name Accession Description Interval E-value
PRK10621 PRK10621
hypothetical protein; Provisional
5-258 2.44e-54

hypothetical protein; Provisional


Pssm-ID: 182593  Cd Length: 266  Bit Score: 176.04  E-value: 2.44e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518666629   5 LSVDLTTLAILAAVAFVAGFIDAIAGGGGLLTTPALLTAGLPPHLVLGTNKLSSTFGAATASFTFYRRKLFHPREWKLAI 84
Cdd:PRK10621   5 FMVSPLLLGVLFFVAMLAGFIDSIAGGGGLLTIPALLAAGMSPAQALATNKLQACGGSFSASLYFIRRKVVNLADQKLNI 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518666629  85 FGTLAGALIGAVVAHYMPAEWLNKMLPVIVFGCGIYLLFggTPKtpIDNDAPIKKKWQLP----QGFGLGFYDGVAGPGT 160
Cdd:PRK10621  85 AMTFVGSMSGALLVQYVQADILRQILPILVIGIGLYFLL--MPK--LGEEDRQRRLYGLPfaliAGGCVGFYDGFFGPGA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518666629 161 GAFWTVSTMLMYPVDLVKASGVARSMNFVSNIAALSVFIFSGHVDWVIGLTMGFAVMIGAFFGARSAISGGAKFIRPVFI 240
Cdd:PRK10621 161 GSFYALAFVTLCGFNLAKATAHAKVLNATSNIGGLLLFILGGKVIWATGFVMLVGQFLGARLGARLVLSKGQKLIRPMIV 240
                        250       260
                 ....*....|....*....|....*
gi 518666629 241 TVVLGLTVRLAW-------QHWFGM 258
Cdd:PRK10621 241 IVSAVMSAKLLYdshgqeiLHWLGM 265
TauE COG0730
Sulfite exporter TauE/SafE/YfcA and related permeases, UPF0721 family [Inorganic ion transport ...
9-256 1.27e-49

Sulfite exporter TauE/SafE/YfcA and related permeases, UPF0721 family [Inorganic ion transport and metabolism];


Pssm-ID: 440494  Cd Length: 250  Bit Score: 163.44  E-value: 1.27e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518666629   9 LTTLAILAAVAFVAGFIDAIAG-GGGLLTTPALLTAGLPPHLVLGTNKLSSTFGAATASFTFYRRKLFHPREWKLAIFGT 87
Cdd:COG0730    1 LMLLLLLLLAGFLAGFLDGLLGvGGGLITVPALLLFGLPPAVAVGTSLLAVVFTSLSGALAHRRRGNVDWRLLLPLALGA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518666629  88 LAGALIGAVVAHYMPAEWLNKMLPVIVFGCGIYLLFGGTPKTPIDNDAPIKKKW-QLPQGFGLGFYDGVAGPGTGAFWTV 166
Cdd:COG0730   81 LIGALLGALLLLLLPADVLKLLFGVLLLLVALLMLLRPKPGAEPERRLPRRSPLlLLLLGFVIGFLSGLFGIGGGFLLVP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518666629 167 STMLMYPVDLVKASGVARSMNFVSNIAALSVFIFSGHVDWVIGLTMGFAVMIGAFFGARSAISGGAKFIRPVFITVVLGL 246
Cdd:COG0730  161 ALVLLLGLPLKRAVATSLALIFVTALAGLIGFALLGYVDWPLALLLALGSLLGAYLGARLARRLPPKLLRRLFAVVLLLV 240
                        250
                 ....*....|
gi 518666629 247 TVRLAWQHWF 256
Cdd:COG0730  241 GLKLLLKALG 250
TauE pfam01925
Sulfite exporter TauE/SafE; This is a family of integral membrane proteins where the alignment ...
16-249 1.46e-34

Sulfite exporter TauE/SafE; This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.


Pssm-ID: 460386  Cd Length: 235  Bit Score: 124.23  E-value: 1.46e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518666629   16 AAVAFVAGFIDAIAGGGGLLTTPALLTAGLPPHLVLGTNKLSSTFGAATASFTFYRRKLFHPREWKLAIFGTLAGALIGA 95
Cdd:pfam01925   1 LLAGLLAGFVGGLLGFGGGLIAVPLLLLLLPPAVAVGTSLLAAVATSLSGALAHRRRGAVDWRLLLRLLLGGLIGALLGA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518666629   96 VVAHYMPAEWLNKMLPVIVFGCGIYLLFGGTP-KTPIDNDAPIKKKWQLPQGFGLGFYDGVAGPGTGAFWTVSTMLMYPV 174
Cdd:pfam01925  81 LLLLLLPEALLKLLFGVLLLLAALLMLLRRRLgAAPRARRRRPGPLALALLGGLIGFLSGLFGIGGGFLLVPALLYLLGL 160
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 518666629  175 DLVKASGVARSMNFVSNIAALSVFIFSGHVDWVIGLTMGFAVMIGAFFGARSAISGGAKFIRPVFITVVLGLTVR 249
Cdd:pfam01925 161 PLKKAVGTSLLLFLVSNLAALLGYALLGAVDWPLLLLLLLGALLGAYLGARLARRLPPRLLRRLFAVLLLLVGLK 235
 
Name Accession Description Interval E-value
PRK10621 PRK10621
hypothetical protein; Provisional
5-258 2.44e-54

hypothetical protein; Provisional


Pssm-ID: 182593  Cd Length: 266  Bit Score: 176.04  E-value: 2.44e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518666629   5 LSVDLTTLAILAAVAFVAGFIDAIAGGGGLLTTPALLTAGLPPHLVLGTNKLSSTFGAATASFTFYRRKLFHPREWKLAI 84
Cdd:PRK10621   5 FMVSPLLLGVLFFVAMLAGFIDSIAGGGGLLTIPALLAAGMSPAQALATNKLQACGGSFSASLYFIRRKVVNLADQKLNI 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518666629  85 FGTLAGALIGAVVAHYMPAEWLNKMLPVIVFGCGIYLLFggTPKtpIDNDAPIKKKWQLP----QGFGLGFYDGVAGPGT 160
Cdd:PRK10621  85 AMTFVGSMSGALLVQYVQADILRQILPILVIGIGLYFLL--MPK--LGEEDRQRRLYGLPfaliAGGCVGFYDGFFGPGA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518666629 161 GAFWTVSTMLMYPVDLVKASGVARSMNFVSNIAALSVFIFSGHVDWVIGLTMGFAVMIGAFFGARSAISGGAKFIRPVFI 240
Cdd:PRK10621 161 GSFYALAFVTLCGFNLAKATAHAKVLNATSNIGGLLLFILGGKVIWATGFVMLVGQFLGARLGARLVLSKGQKLIRPMIV 240
                        250       260
                 ....*....|....*....|....*
gi 518666629 241 TVVLGLTVRLAW-------QHWFGM 258
Cdd:PRK10621 241 IVSAVMSAKLLYdshgqeiLHWLGM 265
TauE COG0730
Sulfite exporter TauE/SafE/YfcA and related permeases, UPF0721 family [Inorganic ion transport ...
9-256 1.27e-49

Sulfite exporter TauE/SafE/YfcA and related permeases, UPF0721 family [Inorganic ion transport and metabolism];


Pssm-ID: 440494  Cd Length: 250  Bit Score: 163.44  E-value: 1.27e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518666629   9 LTTLAILAAVAFVAGFIDAIAG-GGGLLTTPALLTAGLPPHLVLGTNKLSSTFGAATASFTFYRRKLFHPREWKLAIFGT 87
Cdd:COG0730    1 LMLLLLLLLAGFLAGFLDGLLGvGGGLITVPALLLFGLPPAVAVGTSLLAVVFTSLSGALAHRRRGNVDWRLLLPLALGA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518666629  88 LAGALIGAVVAHYMPAEWLNKMLPVIVFGCGIYLLFGGTPKTPIDNDAPIKKKW-QLPQGFGLGFYDGVAGPGTGAFWTV 166
Cdd:COG0730   81 LIGALLGALLLLLLPADVLKLLFGVLLLLVALLMLLRPKPGAEPERRLPRRSPLlLLLLGFVIGFLSGLFGIGGGFLLVP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518666629 167 STMLMYPVDLVKASGVARSMNFVSNIAALSVFIFSGHVDWVIGLTMGFAVMIGAFFGARSAISGGAKFIRPVFITVVLGL 246
Cdd:COG0730  161 ALVLLLGLPLKRAVATSLALIFVTALAGLIGFALLGYVDWPLALLLALGSLLGAYLGARLARRLPPKLLRRLFAVVLLLV 240
                        250
                 ....*....|
gi 518666629 247 TVRLAWQHWF 256
Cdd:COG0730  241 GLKLLLKALG 250
TauE pfam01925
Sulfite exporter TauE/SafE; This is a family of integral membrane proteins where the alignment ...
16-249 1.46e-34

Sulfite exporter TauE/SafE; This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.


Pssm-ID: 460386  Cd Length: 235  Bit Score: 124.23  E-value: 1.46e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518666629   16 AAVAFVAGFIDAIAGGGGLLTTPALLTAGLPPHLVLGTNKLSSTFGAATASFTFYRRKLFHPREWKLAIFGTLAGALIGA 95
Cdd:pfam01925   1 LLAGLLAGFVGGLLGFGGGLIAVPLLLLLLPPAVAVGTSLLAAVATSLSGALAHRRRGAVDWRLLLRLLLGGLIGALLGA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518666629   96 VVAHYMPAEWLNKMLPVIVFGCGIYLLFGGTP-KTPIDNDAPIKKKWQLPQGFGLGFYDGVAGPGTGAFWTVSTMLMYPV 174
Cdd:pfam01925  81 LLLLLLPEALLKLLFGVLLLLAALLMLLRRRLgAAPRARRRRPGPLALALLGGLIGFLSGLFGIGGGFLLVPALLYLLGL 160
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 518666629  175 DLVKASGVARSMNFVSNIAALSVFIFSGHVDWVIGLTMGFAVMIGAFFGARSAISGGAKFIRPVFITVVLGLTVR 249
Cdd:pfam01925 161 PLKKAVGTSLLLFLVSNLAALLGYALLGAVDWPLLLLLLLGALLGAYLGARLARRLPPRLLRRLFAVLLLLVGLK 235
TauE pfam01925
Sulfite exporter TauE/SafE; This is a family of integral membrane proteins where the alignment ...
2-120 3.28e-06

Sulfite exporter TauE/SafE; This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.


Pssm-ID: 460386  Cd Length: 235  Bit Score: 46.81  E-value: 3.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518666629    2 PFELSVDLTTLAILAAVAFVAGFIDAIAG-GGGLLTTPALLTA-GLPPHLVLGTNKLSSTFGAATASFTFYRRKLFHPRE 79
Cdd:pfam01925 115 APRARRRRPGPLALALLGGLIGFLSGLFGiGGGFLLVPALLYLlGLPLKKAVGTSLLLFLVSNLAALLGYALLGAVDWPL 194
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 518666629   80 WKLAIFGTLAGALIGAVVAHYMPAEWLNKMLPVIVFGCGIY 120
Cdd:pfam01925 195 LLLLLLGALLGAYLGARLARRLPPRLLRRLFAVLLLLVGLK 235
TauE pfam01925
Sulfite exporter TauE/SafE; This is a family of integral membrane proteins where the alignment ...
146-257 7.55e-04

Sulfite exporter TauE/SafE; This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane during taurine metabolism as an exporter of sulfoacetate. This family used to be known as DUF81.


Pssm-ID: 460386  Cd Length: 235  Bit Score: 39.87  E-value: 7.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518666629  146 GFGLGFYDGVAGPGTGAFWTvsTMLMYPVDLVKASGVARSMNFVSNIAALSVFIFSGHVDWVIGLTMGFAVMIGAFFGAR 225
Cdd:pfam01925   4 GLLAGFVGGLLGFGGGLIAV--PLLLLLLPPAVAVGTSLLAAVATSLSGALAHRRRGAVDWRLLLRLLLGGLIGALLGAL 81
                          90       100       110
                  ....*....|....*....|....*....|..
gi 518666629  226 SAISGGAKFIRPVFITVVLGLTVRLAWQHWFG 257
Cdd:pfam01925  82 LLLLLPEALLKLLFGVLLLLAALLMLLRRRLG 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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