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Conserved domains on  [gi|518665659|ref|WP_019827369|]
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MULTISPECIES: type II toxin-antitoxin system RelB/DinJ family antitoxin [Pseudomonas]

Protein Classification

type II toxin-antitoxin system RelB/DinJ family antitoxin( domain architecture ID 10013764)

type II toxin-antitoxin (TA) system RelB/DinJ family antitoxin similar to Escherichia coli RelB, the antitoxin component of the RelE-RelB TA module; binds and inhibits the effect of cognate toxin RelE and functions as an autorepressor of relBE operon transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11235 PRK11235
type II toxin-antitoxin system RelB/DinJ family antitoxin;
1-79 7.10e-37

type II toxin-antitoxin system RelB/DinJ family antitoxin;


:

Pssm-ID: 183047  Cd Length: 80  Bit Score: 118.19  E-value: 7.10e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518665659  1 MASINIRIDDELKARAYKELERLGVTPSELVRQALQYVAERGQLPFRPMLVTEEDEALINTVRERLAAPQ-RVKVTLDDL 79
Cdd:PRK11235  1 MATINVRVDDELKARAYAVLEKLGVTPSEALRLLLQYVAENGRLPFKTVLLSDEDAALLETVRERLANPQkGIRVTLDDL 80
 
Name Accession Description Interval E-value
PRK11235 PRK11235
type II toxin-antitoxin system RelB/DinJ family antitoxin;
1-79 7.10e-37

type II toxin-antitoxin system RelB/DinJ family antitoxin;


Pssm-ID: 183047  Cd Length: 80  Bit Score: 118.19  E-value: 7.10e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518665659  1 MASINIRIDDELKARAYKELERLGVTPSELVRQALQYVAERGQLPFRPMLVTEEDEALINTVRERLAAPQ-RVKVTLDDL 79
Cdd:PRK11235  1 MATINVRVDDELKARAYAVLEKLGVTPSEALRLLLQYVAENGRLPFKTVLLSDEDAALLETVRERLANPQkGIRVTLDDL 80
RelB COG3077
Antitoxin component of the RelBE or YafQ-DinJ toxin-antitoxin module [Defense mechanisms];
1-79 8.02e-19

Antitoxin component of the RelBE or YafQ-DinJ toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 442311  Cd Length: 82  Bit Score: 72.60  E-value: 8.02e-19
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 518665659  1 MASINIRIDDELKARAYKELERLGVTPSELVRQALQYVAERGQLPFRPMLVTEEDEALINTVRERLAAPqrVKVTLDDL 79
Cdd:COG3077   4 TANVNVRIDEELKEEAEAVLEELGLTPSDAIRMFLKQVVREGGLPFELKLPNAETLAALEEARKGKGEP--RFDSVDEL 80
RelB_DinJ TIGR02384
addiction module antitoxin, RelB/DinJ family; Plasmids may be maintained stably in bacterial ...
 2-79 4.61e-15

addiction module antitoxin, RelB/DinJ family; Plasmids may be maintained stably in bacterial populations through the action of addiction modules, in which a toxin and antidote are encoded in a cassette on the plasmid. In any daughter cell that lacks the plasmid, the toxin persists and is lethal after the antidote protein is depleted. Toxin/antitoxin pairs are also found on main chromosomes, and likely represent selfish DNA. Sequences in the seed for this alignment all were found adjacent to toxin genes. The resulting model appears to describe a narrower set of proteins than pfam04221, although many in the scope of this model are not obviously paired with toxin proteins. Several toxin/antitoxin pairs may occur in a single species. [Cellular processes, Toxin production and resistance, Mobile and extrachromosomal element functions, Other]


Pssm-ID: 274102  Cd Length: 84  Bit Score: 63.10  E-value: 4.61e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518665659   2 ASINIRIDDELKARAYKELERLGVTPSELVRQALQYVAERGQLPFRPMLVTEEDEALINTVRE--RLAAP-QRVKVTLDD 78
Cdd:TIGR02384  4 ATISIRIDEELKKEAYAVFEELGLTPSTAIRMFLKQVIREQGLPFDLRLPNDETLAAIEEIKElrKLENKfKSVKDLLDD 83


                 .
gi 518665659  79 L 79
Cdd:TIGR02384 84 L 84
RelB pfam04221
RelB antitoxin; RelE and RelB form a toxin-antitoxin system. RelE represses translation, ...
 1-79 2.79e-13

RelB antitoxin; RelE and RelB form a toxin-antitoxin system. RelE represses translation, probably through binding ribosomes. RelB stably binds RelE, presumably deactivating it.


Pssm-ID: 427796  Cd Length: 83  Bit Score: 58.70  E-value: 2.79e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 518665659   1 MASINIRIDDELKARAYKELERLGVTPSELVRQALQYVAERGQLPFRPMLVTEEDEALINTVRERLAAPQRVKVTLDDL 79
Cdd:pfam04221  1 NGSISARIDEDTKAEAYAVLEKMGLTPSQAVRLFLTKVADNKALPFDLRLPSPNDATLVAIVELRAGNGEHKAKSVEVT 79
 
Name Accession Description Interval E-value
PRK11235 PRK11235
type II toxin-antitoxin system RelB/DinJ family antitoxin;
1-79 7.10e-37

type II toxin-antitoxin system RelB/DinJ family antitoxin;


Pssm-ID: 183047  Cd Length: 80  Bit Score: 118.19  E-value: 7.10e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518665659  1 MASINIRIDDELKARAYKELERLGVTPSELVRQALQYVAERGQLPFRPMLVTEEDEALINTVRERLAAPQ-RVKVTLDDL 79
Cdd:PRK11235  1 MATINVRVDDELKARAYAVLEKLGVTPSEALRLLLQYVAENGRLPFKTVLLSDEDAALLETVRERLANPQkGIRVTLDDL 80
RelB COG3077
Antitoxin component of the RelBE or YafQ-DinJ toxin-antitoxin module [Defense mechanisms];
1-79 8.02e-19

Antitoxin component of the RelBE or YafQ-DinJ toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 442311  Cd Length: 82  Bit Score: 72.60  E-value: 8.02e-19
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 518665659  1 MASINIRIDDELKARAYKELERLGVTPSELVRQALQYVAERGQLPFRPMLVTEEDEALINTVRERLAAPqrVKVTLDDL 79
Cdd:COG3077   4 TANVNVRIDEELKEEAEAVLEELGLTPSDAIRMFLKQVVREGGLPFELKLPNAETLAALEEARKGKGEP--RFDSVDEL 80
RelB_DinJ TIGR02384
addiction module antitoxin, RelB/DinJ family; Plasmids may be maintained stably in bacterial ...
 2-79 4.61e-15

addiction module antitoxin, RelB/DinJ family; Plasmids may be maintained stably in bacterial populations through the action of addiction modules, in which a toxin and antidote are encoded in a cassette on the plasmid. In any daughter cell that lacks the plasmid, the toxin persists and is lethal after the antidote protein is depleted. Toxin/antitoxin pairs are also found on main chromosomes, and likely represent selfish DNA. Sequences in the seed for this alignment all were found adjacent to toxin genes. The resulting model appears to describe a narrower set of proteins than pfam04221, although many in the scope of this model are not obviously paired with toxin proteins. Several toxin/antitoxin pairs may occur in a single species. [Cellular processes, Toxin production and resistance, Mobile and extrachromosomal element functions, Other]


Pssm-ID: 274102  Cd Length: 84  Bit Score: 63.10  E-value: 4.61e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518665659   2 ASINIRIDDELKARAYKELERLGVTPSELVRQALQYVAERGQLPFRPMLVTEEDEALINTVRE--RLAAP-QRVKVTLDD 78
Cdd:TIGR02384  4 ATISIRIDEELKKEAYAVFEELGLTPSTAIRMFLKQVIREQGLPFDLRLPNDETLAAIEEIKElrKLENKfKSVKDLLDD 83


                 .
gi 518665659  79 L 79
Cdd:TIGR02384 84 L 84
RelB pfam04221
RelB antitoxin; RelE and RelB form a toxin-antitoxin system. RelE represses translation, ...
 1-79 2.79e-13

RelB antitoxin; RelE and RelB form a toxin-antitoxin system. RelE represses translation, probably through binding ribosomes. RelB stably binds RelE, presumably deactivating it.


Pssm-ID: 427796  Cd Length: 83  Bit Score: 58.70  E-value: 2.79e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 518665659   1 MASINIRIDDELKARAYKELERLGVTPSELVRQALQYVAERGQLPFRPMLVTEEDEALINTVRERLAAPQRVKVTLDDL 79
Cdd:pfam04221  1 NGSISARIDEDTKAEAYAVLEKMGLTPSQAVRLFLTKVADNKALPFDLRLPSPNDATLVAIVELRAGNGEHKAKSVEVT 79
COG4710 COG4710
Predicted DNA-binding protein with an HTH domain [General function prediction only];
1-79 2.86e-04

Predicted DNA-binding protein with an HTH domain [General function prediction only];


Pssm-ID: 443745  Cd Length: 76  Bit Score: 35.65  E-value: 2.86e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518665659  1 MASINIRIDDELKARAYKELERLGVTPSELVRQAL-QYVAERgqlpfrpmlvteEDEALINTVRERLAAPQRVKVTLDDL 79
Cdd:COG4710   1 MKMLSIRLPEELEARLDALAKRTGRSKSFYVREAIeEYLDDL------------EDYYLAEERLERVRAGREKTYSLEEV 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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