|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10054 |
PRK10054 |
efflux MFS transporter YdeE; |
11-385 |
1.12e-53 |
|
efflux MFS transporter YdeE;
Pssm-ID: 182213 Cd Length: 395 Bit Score: 182.64 E-value: 1.12e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 11 LMICSVTIVVSRAMTSPLLALWLSTRLGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRKLLILAMLSSSIGFLLLT 90
Cdd:PRK10054 12 LLASSLLLTIGRGATLPFMTIYLSRQYSLSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITAFASGFIAIP 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 91 FASNLYLTTLTLVVTEAASALFLIGSKAIISENLPVGERAKVFSLRYTLTNVGYATGPMLGVVIAGQLPWAPFLIAsAIA 170
Cdd:PRK10054 92 LVNNVTLVVLFFALINCAYSVFSTVLKAWFADNLSSTSKTKIFSLNYTMLNIGWTVGPPLGTLLVMQSINLPFWLA-AIC 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 171 FGSLFLMIGIAPTQRDDSH-KPQSFLSTLRILRSDRTLILFTSGSLLSTIVHGRYTLYLSQFLLVAYTPDQALKILSAVL 249
Cdd:PRK10054 171 SAFPLVFIQIWVQRSEKAIaTETGSVWSPSVLLQDKALLWFTCSGFLASFVSGAFASCISQYVMVVADSDFAEKVVAVVL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 250 ACNAITVILMQYQIGRFLKREQLRHWIVLGTLLFIVGLVGFSQA-HSLLTWCLAMFVFTLGEMIIYPSEFLFIDTIAPDA 328
Cdd:PRK10054 251 PVNAAMVVSLQYSVGRRLNAANIRPLMTAGTLCFVIGLVGFIFSgNSLLLWGMSAAVFTVGEIIYAPGEYMLIDHIAPPG 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 518655945 329 LRGSYYGAQNLAAFGGAMSPVICGYLLINAAPTSMFFALAALTAMgGTLCFLSGRRV 385
Cdd:PRK10054 331 MKASYFSAQSLGWLGAAINPLVSGVILTTLPPWSLFVILALAIVA-AWLLMLKGMRA 386
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
8-370 |
5.41e-50 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 172.41 E-value: 5.41e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 8 IRRLMICSVTIVVSRAMTSPLLALWLSTRLGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRKLLILAMLSSSIGFL 87
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 88 LLTFASNLYLTTLTLVVTEAASALFLIGSKAIISENLPVGERAKVFSLRYTLTNVGYATGPMLGVVIAGQLPWAPFLIAS 167
Cdd:cd17329 81 LLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 168 AIAFGS-LFLMIGIAPTQRDD-SHKPQSFLSTLRILRSDRTLILFTSGSLLSTIVHGRYTLYLSQFLLVAytPDQALKIL 245
Cdd:cd17329 161 VLFLLAaLVLLFLLPETRPKRrAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEI--LGLGESLL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 246 SAVLACNAITVILMQYQIGRFLKREQLRHWIVLGTLLFIVGLVGFSQAHSLLTWCLAMFVFTLGEMIIYPSEFLFIDTIA 325
Cdd:cd17329 239 GLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALA 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 518655945 326 PDALRGSYYGAQNLA-AFGGAMSPVICGYLLINAAPTSMFFALAAL 370
Cdd:cd17329 319 PPDKRGSYMGFYALAwGLGRAIGPLVGGLLLDLLGPGLPWLILAAL 364
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
6-345 |
5.96e-28 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 112.37 E-value: 5.96e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 6 LVIRRLMICSVTIVVSRAMTSPLLAlWLSTRLGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRKLLILAMLSSSIG 85
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 86 FLLLTFASNLYLTTLTLVVTEAASALFLIGSKAIISENLPVGERAKVFSLRYTLTNVGYATGPMLGVVIAGQLPW-APFL 164
Cdd:COG2814 89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWrWVFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 165 IASAIAFGSLFLMIGIAPtqRDDSHKPQSFLSTLRILRSDRTLILFTSGSLLSTIVHGRYTLYLSQFLLVAYtpDQALKI 244
Cdd:COG2814 169 VNAVLALLALLLLLRLLP--ESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL--GLSASA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 245 LSAVLACNAITVILMQYQIGRFLKREQLRHWIVLGTLLFIVGLVGFSQAHSLLTWCLAMFVFTLGEMIIYPSEFLFIDTI 324
Cdd:COG2814 245 AGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAEL 324
|
330 340
....*....|....*....|.
gi 518655945 325 APDALRGSYYGAQNLAAFGGA 345
Cdd:COG2814 325 APPEARGRASGLYNSAFFLGG 345
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
24-380 |
4.62e-25 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 104.97 E-value: 4.62e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 24 MTSPLLALwLSTRLGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRKLLILAMLSSSIGFLLLTFASNLYLTTLTLV 103
Cdd:cd17325 14 IIIPILPL-YAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 104 VTEAASALFLIGSKAIISENLPVGERAKVFSLRYTLTNVGYATGPMLGVVIAGQLPW-APFLIASAIAFGSLFLMIGI-- 180
Cdd:cd17325 93 LQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYrAPFLVCAALALLALVLALLLlp 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 181 --APTQRDDSHKPQSFLSTLRILRSDRTLILFTSGSLLSTIVHGRYTLYLSQFL--LVAYTPDQalkiLSAVLACNAITV 256
Cdd:cd17325 173 epRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAaeLGGLSPAQ----IGLLFGAQGLAS 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 257 ILMQYQIGRFLKREQLRHWIVLGTLLFIVGLVGFSQAHSLLTWCLAMFVFTLGEMIIYPSEFLFIDTIAPDALRGSYYGA 336
Cdd:cd17325 249 ALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGL 328
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 518655945 337 QNLA-AFGGAMSPVICGYLLINAAPTSMFFALAALTAMGGTLCFL 380
Cdd:cd17325 329 FNTAfSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
11-346 |
2.27e-20 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 90.94 E-value: 2.27e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 11 LMICSVTIVVSRAMTSPLLALWLSTRLGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRKLLILAMLSSSIGFLLLT 90
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 91 FASNLYLTTLTLVVTEAASALFLIGSKAIISENLPVGERAKVFSLRYTLTNVGYATGPMLGVVIAGQLPW-APFLIASAI 169
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWrAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 170 AFGSLFLMIGIAP-----TQRDDSHKPQSFLSTLRILRSDRTLILFTSGSLLSTIVHGRYTLYLSQFLLVAYTPDQALKI 244
Cdd:pfam07690 161 SLLAAVLLLLPRPppeskRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 245 LSAVLACNAITVILMQYQIGRFLKREQLRhWIVLGTLLFIVGLVGFSQAHSLLTWCLAMFVFTLGEMIIYPSEFLFIDTI 324
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRRRRLL-LALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDL 319
|
330 340
....*....|....*....|..
gi 518655945 325 APDALRGSYYGAQNLAAFGGAM 346
Cdd:pfam07690 320 APKEERGTASGLYNTAGSLGGA 341
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
37-380 |
2.84e-20 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 91.09 E-value: 2.84e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 37 LGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRKLLILAMLSSSIGFLLLTFASNLYLTTLTLVVTEAASALFLIGS 116
Cdd:cd17474 29 LGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 117 KAIISENLPVGERAKVFSLRYTLTNVGYATGPMLGVVIAG---QLPWAPFLIASAIAFGSLFLMigIAPTQRDDSHKPQS 193
Cdd:cd17474 109 LTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAiswRYPFFLLAALIPVAFLAILFL--LPEPKEKAKSSSAT 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 194 FLSTLRILRSDRTLILFTSGSLLSTIVHGRYTLYLSqfLLVAYTPDQALKILSAVLACNAITVILMQYQIGRFLKREQLR 273
Cdd:cd17474 187 KLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLP--FLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGA 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 274 HWIVL-GTLLFIVGLVGFSQAHSLLTWCLAMFVFTLGEMIIYPSEFLFIDTIAPDALRGSYYGAQNLAAF-GGAMSPVIC 351
Cdd:cd17474 265 RRILViGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFlGQAVGPLLF 344
|
330 340
....*....|....*....|....*....
gi 518655945 352 GYLLINAAPTSMFFALAALTAMGGTLCFL 380
Cdd:cd17474 345 GLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
27-386 |
2.60e-19 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 88.39 E-value: 2.60e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 27 PLLALWLSTRLGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRKLLILAMLSSSIGFLLLTFASNLYLTTLTLVVTE 106
Cdd:COG2271 30 SVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 107 AASALFLIGSKAIISENLPVGERAKVFSLRYTLTNVGYATGPMLGVVIAGQLPW-APFLIASAIAFGSLFLmigiaptqr 185
Cdd:COG2271 110 LGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWrAAFLILGLPGLLLALL--------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 186 ddshkpqsflstlrilrsdRTLILFTSGSLLSTIVHGrYTLYLSQFL--LVAYTPDQALKILSAVLACNAITVILMQYQI 263
Cdd:COG2271 181 -------------------RFWLLALAYFLVYFALYG-FLTWLPTYLveVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 264 GRFLKREqlRHWIVLGTLLFIVGLVGFSQAHSLLTWCLAMFVFTLGEMIIYPSEFLFIDTIAPDALRGSYYGAQNLAAF- 342
Cdd:COG2271 241 DRLGRRR--KLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFl 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 518655945 343 GGAMSPVICGYLLINAAPTSMFFALAALTAMGGTLCFLSGRRVA 386
Cdd:COG2271 319 GGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
9-178 |
2.15e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 82.62 E-value: 2.15e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 9 RRLMICSVTIVV---SRAMTSPLLALWLSTRLGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRKLLILAMLSSSIG 85
Cdd:cd17325 199 RRLLALFLAIFVlafAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVA 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 86 FLLLTFASNLYLTTLTLVVTEAASALFLIGSKAIISENLPVGERAKVFSLRYTLTNVGYATGPMLGVVIAGQLPWA-PFL 164
Cdd:cd17325 279 LLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFAtPFL 358
|
170
....*....|....
gi 518655945 165 IASAIAFGSLFLMI 178
Cdd:cd17325 359 AAAALLLLAAVLFL 372
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
23-355 |
2.26e-16 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 80.33 E-value: 2.26e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 23 AMTSPLLALWLSTRLGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRK-----LLILAMLSSSIGFLLLTFASNLYL 97
Cdd:COG2211 27 GLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpWILIGAIPLALSFVLLFTAPDLSP 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 98 TT------LTLVVTEAASALFLIGSKAIISENLP-VGERAKVFSLRYTLTNVGYATGPMLGVVIAGQLP-------WAPF 163
Cdd:COG2211 107 TGkliyalVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGgdaalgyRLTA 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 164 LIASAIAFGSLFLMIGIAPTQRDDSHKPQSFLSTLRILRSDRTLILFTSGSLLSTIvhGRYTLYLSQFLLVAYTPDQALK 243
Cdd:COG2211 187 LIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFL--ALALVAALLLYYFKYVLGLSAA 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 244 ILSAVLACNAITVILMQYQIGRFLKREQLRHWIVLGTLLFIVGLVG--FSQAHSLLTWCLAMFVFTLGEMIIYPSEFLFI 321
Cdd:COG2211 265 LVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLlfFLGPGNLWLLLVLAALAGIGLGAILVLPWAML 344
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 518655945 322 -DTIAPDALR------GSYYGAQNLA-AFGGAMSPVICGYLL 355
Cdd:COG2211 345 aDVVDYDEWKtgrrreGLYFGIFTFAiKLGQALAGALAGLLL 386
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
11-379 |
1.10e-15 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 77.59 E-value: 1.10e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 11 LMICSVTIVVSRAMTSPLLALwLSTRLGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRKLLILAMLSSSIGFLLLT 90
Cdd:cd17324 4 LALAAFAIGTTEYVIQGLLPD-IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 91 FASNLYLTTLTLVVTEAASALFLIGSKAIISENLPVGERAKVFSLRYTLTNVGYATGPMLGVVIAGQLPW-APFLIASAI 169
Cdd:cd17324 83 LAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWrAAFLAIAVL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 170 AFGSLFLMIGIAPTQRDDSHKPQSFLST-LRILRSDRTLILFTSGSLLSTIVHGRYTlYLSQFLL-VAYTPDQAlkiLSA 247
Cdd:cd17324 163 ALLAALLLWRLLPSLPPKKPGSLGLLSSlLLLLRNPRLRLAYLITFLLFGGFFALYT-YLAPFLTdVPGFSSSA---IIG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 248 VLACNAITVILMQYQIGRFLKREQLRHWIVLGTLLFIVGLVGFSQAHSLLTWCLAMFVFTLGEMIIYPSEFLFIDTIAPD 327
Cdd:cd17324 239 LLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPE 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 518655945 328 ALrgSYYGAQNLAAF--GGAMSPVICGYLLINAAPTSMFFALAALTAMGGTLCF 379
Cdd:cd17324 319 AR--GLASSLYLAAYnlGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
30-377 |
1.67e-15 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 77.27 E-value: 1.67e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 30 ALWLSTRLGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRKLLILAMLSSSIGFLLLTFASNLYLTTL-----TLVV 104
Cdd:cd06173 22 LPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLwlllvLAFL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 105 TEAASALFLIGSKAIISENLPVGERAKVFSLRYTLTNVGYATGPMLGVVIAGQL-PWAPFLIASAIAFGSLFLMIGIAPT 183
Cdd:cd06173 102 LGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLgPGGAFAINALSFLLSALLLLFIRRP 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 184 QRDDSHKP-----QSFLSTLRILRSDRTLILFTSGSLLSTIVHGRYTLYLSqfLLVAYTPDQALKILSAVLACNAITVIL 258
Cdd:cd06173 182 PPAAPGESsslllRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLP--LLAKEVLGGGAAGYGLLLAAFGVGALL 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 259 MQYQIGRFLKREQLRHWIVLGTLLFIVGLVGFSQAHSLLTWCLAMFVFTLGEMIIYPSEFLFIDTIAPDALRGSYYGAQN 338
Cdd:cd06173 260 GALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYN 339
|
330 340 350
....*....|....*....|....*....|....*....
gi 518655945 339 LAAFGGAMSPVICGYLLINAAPTSMFFALAALTAMGGTL 377
Cdd:cd06173 340 ALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAAL 378
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
11-379 |
5.61e-15 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 75.54 E-value: 5.61e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 11 LMICSVTIVVSRAMTSPLLALWLsTRLGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRKLLILAMLSSSIGFLLLT 90
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALL-QSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 91 FASNLYLTTLTLVVTEAASALFLIGSKAIISENLPVGERAKVFSLRYTLTNVGYATGPMLGVVIAGQLPW---APFLIAS 167
Cdd:cd06174 80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFgwrAVFLIAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 168 AIAFGSLFLMI------GIAPTQRDDSHKPQSFLSTLRILRSDRTLILFTSGSLLSTIVHGRYTLYLSQFLL--VAYTPD 239
Cdd:cd06174 160 ALALLAAILLLlvvpdpPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLdlGGLSVA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 240 QALKILSAVLACNAITVILMQYQIGRFLKReqlRHWIVLGTLLFIVGLVGFSQAHSLLTWCLAMFVFTLGEMIIYPSEFL 319
Cdd:cd06174 240 VAGLLLSLFGLAGALGSLLLGLLSDRLIGR---KPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFA 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518655945 320 FIDTIAPDALRGSYYGAQNLAAFGGAM--SPVICGYLLINAAPTSMFFALAALTAMGGTLCF 379
Cdd:cd06174 317 LIAELFPPEIRGTAFGLLNTFGFLGGAigPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
27-374 |
6.87e-15 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 75.32 E-value: 6.87e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 27 PLLALWLSTrLGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRKLLILAMLSSSIGFLLLTFASNLYLTTLTLVVTE 106
Cdd:cd17489 17 PVLPLYAHD-LGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 107 AASALFLIGSKAIISENLPVGERAKVFSLRYTLTNVGYATGPMLGVVIAGQL-PWAPFLIASAIAFGSLFLMIGIAPTQR 185
Cdd:cd17489 96 IGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLgFAVLFIVAAVLALLALLLVFLVKDPPP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 186 DDSHKPQSFLSTLRILRSDR----TLILFTSGSLLSTIvhgrytlylsQFLLVAYTPDQALKILSAVLACNAITVILMQY 261
Cdd:cd17489 176 VAAEEAEAGTRAFRRLVEKKvlppALILFLASIAYGAI----------STFLPLYAAERGISNAGLFFTVYAIALLLSRP 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 262 QIGRFLKREQLRHWIVLGTLLFIVGLVGFSQAHSLLTWCLAMFVFTLGEMIIYPSEFLFIDTIAPDALRGSYYGAQNLA- 340
Cdd:cd17489 246 FSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFf 325
|
330 340 350
....*....|....*....|....*....|....
gi 518655945 341 AFGGAMSPVICGYLLINAAPTSMFFALAALTAMG 374
Cdd:cd17489 326 DLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLA 359
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
11-380 |
9.52e-15 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 74.92 E-value: 9.52e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 11 LMICSVTIVVSrAMTSPLLALWLSTRLGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRKLLILAMLSSSIGFLLLT 90
Cdd:cd17473 5 LLASTLTVMAG-AAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 91 FASNLYLTTLTLVVTEAASALFLIGSKAIISENLPVGERAKVFSLRYTLTNVGYATGPMLGVVIAgQLPW-APFLI-ASA 168
Cdd:cd17473 84 FLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALA-EIGWrAPFLVyLLA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 169 IAFGsLFLMIGIAPTQRDDSHKPQSFLSTLRILRSDRTLILFTSGSLLSTIVhgrYTLYLSQFLLVAYTPDQALKILSAV 248
Cdd:cd17473 163 LPVL-ILVLLFLPEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLF---YVIPIQLPFLLQERGGGSAALIGLA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 249 LACNAITVILMQYQIGRFLKREQLRHWIVLGTLLFIVGLVGFSQAHSLLTWCLAMFVFTLGEMIIYPSEFLFIDTIAPDA 328
Cdd:cd17473 239 LAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPE 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 518655945 329 LRGSYYGAQNLAAFGGAM-SPVICGYLLINAAPTSMFFALAALTAMGGTLCFL 380
Cdd:cd17473 319 LRGRAMGIVTSAFFLGQFlSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLL 371
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
29-384 |
1.93e-14 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 74.15 E-value: 1.93e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 29 LALWLSTRLGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRKLLILAMLSSSIGFLLLTFASNLYLTTLTLVVTEAA 108
Cdd:COG2223 27 LAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 109 SALFLIGSKAIISENLPVGERAKVFSLRYTLTNVGYATGPMLGVVIAGQLPW-APFLIASAIAF--GSLFLMIGIAPTQR 185
Cdd:COG2223 107 GGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWrNAFLILGILLLvvAVLAWLFLRDPPAG 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 186 DDSHKPQSFLSTLRILRSDRTLILFTSGSLLSTIVHGrYTLYLSQFLLVAY--TPDQALKILSAVLACNAITVILMqyqi 263
Cdd:COG2223 187 AAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIG-FSSWLPPYLVDQFglSAATAGLLAALFALLGALGRPLG---- 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 264 GRFLKREQLRHWIVLGTLLFIVGLVGFSQAHS---LLTWCLAMFVFTLGemIIYPSEFLFIDTIAPDALRGSYYGAQNLA 340
Cdd:COG2223 262 GWLSDRIGGRRVLLIVFALMALGLLLLALALGslwLFLVLFLLLGLALG--GGNGAVFALVPDIFPTKNAGAVYGLVGAA 339
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 518655945 341 -AFGGAMSPVICGYLLINA-APTSMFFALAALTAMGGTLCFLSGRR 384
Cdd:COG2223 340 gGLGGFLGPLLFGALLDATgSYTAAFLVFAVLALVALVLTLLLYRR 385
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
11-372 |
4.11e-14 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 72.98 E-value: 4.11e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 11 LMICSVTIVVSRAMTSPLLALWLsTRLGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRKLLILAMLSSSIGFLLLT 90
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRL-EREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 91 FASNLYLTTLTLVVTEAASALFLIGSKAIISENLPVGERAKVFSLRYTLTNVGYATGPMLgVVIAGQLPWAPFLIASAIA 170
Cdd:cd17477 80 LTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLL-LALVGTAGALPFLIAAVLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 171 FGSL--FLMIGIAPTQRDDSHKpqsfLSTLRILRSDRTLIL--FTSGsLLSTIVHGRYTLYLSQfllVAYTPDQALKILS 246
Cdd:cd17477 159 LLALvpLLLTRRAAPEIEEAES----ISLRRLLRIAPLALLgaFVAG-FLEGAFYSLLPLYGLR---LGLSVAQAALLLA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 247 AVLACNaitvILMQYQIGRFLKREQLRHWIVLGTLLFIVGLVGFSQAHSLLTWCLAM-FVFTLGEMIIYPSEFLFIDTIA 325
Cdd:cd17477 231 AFVLGG----LLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLlFLWGGAAGPLYTLALALAGDRL 306
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 518655945 326 PDALRGSYYGAQNLA-AFGGAMSPVICGYLLINAAPTSMFFALAALTA 372
Cdd:cd17477 307 PGDELVAANAALLLLyGLGSVIGPLLAGALMDAFGPHGLFLFLAAVAL 354
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
20-377 |
2.46e-13 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 70.65 E-value: 2.46e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 20 VSRAMTSPLLALWLSTrLGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRKLLILAMLSSSIGFLLLTFASNLYLTT 99
Cdd:cd17370 13 ISYEMARSILPLFLVV-LGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLVILGYGLSALAKPLLALAGSWQLV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 100 LTLVVTEAASALFLIGSK-AIISENLPVGERAKVFSLRYTLTNVGYATGPMLGVVIAGQLPWAP---FLIASAIAFGSLF 175
Cdd:cd17370 92 LLLRILERLGKGIRTPPRdALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGGNYrtiFLLAAIPALLALL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 176 LMIgIAPTQRDDSHKPQSFLSTLRILRSDRTLILFTSGSLLSTIVHGRYTLYLSQFLLVAYTPDQAlkilSAVLACNAIT 255
Cdd:cd17370 172 ILL-FVVKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGNFSFAFLILRAQELGLSAALI----PLLYALFNLV 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 256 VILMQYQIGRFLKREQLRHWIVLGTLLFIVGLVGFSQAHSLLTWCLAMFVFTLGEMIIYPSEFLFIDTIAPDALRGSYYG 335
Cdd:cd17370 247 YALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYG 326
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 518655945 336 AQNLA-AFGGAMSPVICGYLLINAAPTSMFFALAALTAMGGTL 377
Cdd:cd17370 327 LFNTVvGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLL 369
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
26-303 |
4.64e-11 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 63.73 E-value: 4.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 26 SPLLALwLSTRLGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRKLLILAMLSSSIGFLLLTFASNLYLTTLTLVVT 105
Cdd:cd17478 16 PALLPL-LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 106 EAASALFLIGSKAIISENLPvGERAKVFSLRYTLTNVGYATGPMLGVVIA---GQLPWAPFLIASAIAFGSLFLMIgIAP 182
Cdd:cd17478 95 GIGSAAFHPEGARLASQAAG-GRRGLAMSIFSVGGNLGFALGPLIAAALValfGGLGLLILLIIPGLAVALLLLRL-RPL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 183 TQRDDSHKPQSFLSTLRILRSDRTLILFTSGSLLSTIVHGRYTLYLSQFLL-VAYTPDQALKILSAVLACNAITVILMqy 261
Cdd:cd17478 173 KKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVqRGYSLVFAGLLLSLFLFAGAIGTLIG-- 250
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 518655945 262 qiGRFLKREQLRHWIVLGTLLFIVGLVGFSQAHSLLTWCLAM 303
Cdd:cd17478 251 --GPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLV 290
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
8-177 |
5.83e-11 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 63.37 E-value: 5.83e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 8 IRRLMICSVTIVVSRAMTSPLLALWLSTRLGLNQQDIGLLMGVAVFIATLM-GLYGGYIIDRLEKRKLLILAMLSSSIGF 86
Cdd:cd17330 176 LRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAqLLLIPRLAKRLGERKLLRLGLLLAIIGL 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 87 LLLTFASNLYLTTLTLVVTEAASALFLIGSKAIISENLPVGERAKVFSLRYTLTNVGYATGPML-GVVIAGQLPWAPFLI 165
Cdd:cd17330 256 LLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLaGPLYSFLGPGVPFLL 335
|
170
....*....|..
gi 518655945 166 ASAIAFGSLFLM 177
Cdd:cd17330 336 AAGLLLIALFLL 347
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
26-385 |
1.39e-10 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 62.20 E-value: 1.39e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 26 SPLLALwLSTRLGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRKLLILAMLSSSIGFLLLTFASNLYLTTLTLVVT 105
Cdd:COG2807 38 GPLLPE-IRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALI 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 106 EAASALFLIGSKAIISENLPvGERAKVFSLRYTLTNVGYATGPMLGVVIAGQLPWAP-FLIASAIAFGSLFLMIGIAPTQ 184
Cdd:COG2807 117 GAGIAVGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGaLAVWALLALLALLLWLPLLRRR 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 185 RDDSHKPQSFLSTLRILRSDRTLIL---FTSGSLLSTIVHGrytlYLSQFLLVA-YTPDQALKILSAVLACNAITVILMQ 260
Cdd:COG2807 196 PAAAAAAPAAASLRSLWRSPLAWLLtlfFGLQSLLYYAVVA----WLPPILRDAgLSAATAGLLLSLFQLAGIPGSLLVP 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 261 YQIGRFLKReqlRHWIVLGTLLFIVGLVGFSQAHSLLTWcLAMFVFTLGEMIIYPSEFLFIDTIAPDALR-GSYYG-AQN 338
Cdd:COG2807 272 LLADRLGDR---RPLLLLLGLLGLAGLLGLLLAPGSLPW-LWAVLLGLGQGGLFPLALTLIGLRARTPAEaAALSGmAQS 347
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 518655945 339 LAAFGGAMSPVICGYLL-INAAPTSMFFALAALTAMGGTLCFLSGRRV 385
Cdd:COG2807 348 VGYLLAALGPLLVGALHdATGSWTAALLLLAALAVLMLVAGLLAGRPY 395
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
37-380 |
2.93e-10 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 61.05 E-value: 2.93e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 37 LGLNQQDIGLLMGvAVFIA-TLMGLYGGYIIDRLEKRKLLILAMLSSSIGFLLLTFASNLYLTTLTLVVTEAASALFLIG 115
Cdd:cd17319 33 LGLSPTQYGLIAS-AFFLGyALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 116 SKAIISENLPVGERAKVFSLRYTLTNVGYATGPMLGVVIAGQLPWApfliasaiafgSLFLMIGIAptqrddshkpqSFL 195
Cdd:cd17319 112 AIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWR-----------WAFIIEGLL-----------GLL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 196 STLRILRSDRTLILFTSGSLLSTIVHGRYTLYLSQFLLVAY--TPDQALKILSAVLACNAITVILMQYQIGRFLKREQLR 273
Cdd:cd17319 170 LAVLWWFYLRQVWGLALGYFGINYALYGLLTWLPTYLKQARgfSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 274 HwIVLGTLLFIVGLVGFSQAHSLLTWCLAMFVFTLGEMIIYPSEFLFIDTIAPDALRGSYYGAQN-LAAFGGAMSPVICG 352
Cdd:cd17319 250 V-IIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINsGGNLGGFVAPLLIG 328
|
330 340
....*....|....*....|....*....
gi 518655945 353 YLL-INAAPTSMFFALAALTAMGGTLCFL 380
Cdd:cd17319 329 YLVdATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
63-374 |
6.58e-09 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 56.82 E-value: 6.58e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 63 GYIIDRLEKRKLLILAMLSSSIGFLLLTFASNLYLTTLTLVVTEAASALFLIgSKAIISENLPVGERAKVFSLRYTLTNV 142
Cdd:cd17330 55 GRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSV-AQAYIADITDEEERAKAFGIISAAFGL 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 143 GYATGPMLGVVIAGQLPWA-PFLIASAIAFGSLFLMIgiaptqrddshkpqSFLSTLRilrsdRTLILFTSGSLLSTIVH 221
Cdd:cd17330 134 GFILGPALGGFLSTPYGYAlPFLVAAALALLNLVLVL--------------FFLPPLR-----RLLLVYFLIALAFAGLE 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 222 GRYTLYLSQFLlvAYTPDQALKILSAVLACNAITVILMqyqIGRFLKREQLRHWIVLGTLLFIVGLVGFSQAHSLLTWCL 301
Cdd:cd17330 195 SVFSLFLKDRF--GFSPSQIGLLLALVGIAGILAQLLL---IPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVL 269
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 518655945 302 AMFVFTLGEMIIYPSEFLFIDTIAPDALRGSYYG-AQNLAAFGGAMSPVICGYLLINAAPTSMFFALAALTAMG 374
Cdd:cd17330 270 AAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGiIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIA 343
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
11-297 |
1.10e-08 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 56.40 E-value: 1.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 11 LMICSVTIVVSRAMTSPLLALWLSTRLGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRK-LLILAMLSSSIGFLLL 89
Cdd:cd17471 1 LLLATLLTGLAGAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRKpLILLALLAGALGYLLF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 90 TFASNLY--LTTLTLVVTEAASALFLIGSKAIISENLPVGERAKVFS--LRyTLTNVGYATGPMLGVVIAGQLPWAPFLI 165
Cdd:cd17471 81 AFLRNYWvlLLVGVVLLSLGAAAFPQLFALAREYADRSSGRDATLFNsvLR-AAFSLAWVIGPPLAFLLLDVLGFTGLFL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 166 ASAIAFGSLFLMIGIAPTQRDDSHKPQSFLSTLRILRSDRTLILFTSGSLLSTIVHGRYTLYLSqfLLVAYTPDQALKIL 245
Cdd:cd17471 160 LAALLYLVVALLVLFLLPSVKPPAQKATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMP--LYVTNELGGSESWV 237
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 518655945 246 SAVLACNAITVILMQYQIGRFLKREQLRHWIVLGTLLFIVGLVGFSQAHSLL 297
Cdd:cd17471 238 GLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLW 289
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
38-374 |
1.70e-08 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 56.47 E-value: 1.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 38 GLNQQDIGLLMGVAVFIA--TLMGLYGGYIIDRLEKRKLLILAMLSS---SIGFLLLTFASNLYLTTLTLVVTEAASALF 112
Cdd:PRK08633 41 DGSEQVILTAIVNALFLLpfLLLSSPAGFLADKFSKNRVIRIVKLFEvglTLLIVLAYYLGWFWLAFAVTFLLGAQSAIY 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 113 LIGSKAIISENLPVGERAKVFSLRYTLTNVGYATGPMLGVVI-----------AGQLPWAPFLIASAIAFGSLFLMIGIA 181
Cdd:PRK08633 121 SPAKYGIIPELVGKENLSRANGLLEAFTIVAILAGTALFSFLfesvngntpseILGRIAPAGLVLLAVAVLGLIFAYRLP 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 182 PT--------QRDDSHKPQSFLSTLRILRSDRTLILftsgsllsTIVHGRYTLYLSQFLLVAYTP--------DQALKIl 245
Cdd:PRK08633 201 KVpaaapevfDKKKYLFPKLLWRNLKLLRSDRVLWL--------AIIGLSYFWFISQLAQANFPAyakevlglDNTFQV- 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 246 SAVLACNAITVILMQYQIGRFLKREQLRHWIVLGTLLFIVGLVGFSQAHSLLTWCLAMFVF-TLGEMIIYPSEfLFIDTI 324
Cdd:PRK08633 272 QYLLAASAIGIGIGSLLAGRLSGRHIELGLVPLGALGLALSLFLLPTAPSLASVLVLFFLFgFSAGLFIVPLN-ALIQFR 350
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 518655945 325 APDALRGSYYGA----QNLAAFGGAMSPVICGYLLINaaPTSMFFALAALTAMG 374
Cdd:PRK08633 351 APEKELGKVLAAnnflQNVGMLLFLALTTLFSGLGLS--PAGLFYLIALVTLIG 402
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
10-178 |
3.56e-08 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 54.86 E-value: 3.56e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 10 RLMICSVTIVVSRAMTSPLLALWLStRLGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRKLLILAMLSSSIGFLLL 89
Cdd:cd17370 203 WLYLLAVALFALGNFSFAFLILRAQ-ELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGF 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 90 TFASNLYLTTLTLVVTEAASALFLIGSKAIISENLPVGERAKVFSLRYTLTNVGYatgpMLGVVIAGQL-----PWAPFL 164
Cdd:cd17370 282 ALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGW----LLASLIAGYLwdlisPSAAFL 357
|
170
....*....|....
gi 518655945 165 IASAIAFGSLFLMI 178
Cdd:cd17370 358 FSAVLALIALLLLL 371
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
6-185 |
3.58e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 54.88 E-value: 3.58e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 6 LVIRRLMICSVTIVVSRAMTSPLLALWLSTRLGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRK--LLILAMLSSS 83
Cdd:COG2271 180 LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 84 IGFLLLTFASNLYLTTLTLVVTEAASALFLIGSKAIISENLPVGERAKVFSLRYTLTNVGYATGPMLGVVIAGQLPW-AP 162
Cdd:COG2271 260 LALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYqAA 339
|
170 180
....*....|....*....|...
gi 518655945 163 FLIASAIAFGSLFLMIGIAPTQR 185
Cdd:COG2271 340 FLLLAALALLAALLALLLLRETR 362
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
8-170 |
1.60e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 52.62 E-value: 1.60e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 8 IRRLMICSVTIVVSRAMTSPLLALWLSTRLGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRKLLILAMLSSSIGFL 87
Cdd:cd06173 210 LRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALL 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 88 LLTFASNLYLTTLTLVVTEAASALFLIGSKAIISENLPVGERAKVFSLRYTLTNVGYATGPMLGVVIAGQLPWAPFLIAS 167
Cdd:cd06173 290 VLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLA 369
|
...
gi 518655945 168 AIA 170
Cdd:cd06173 370 GAL 372
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
8-176 |
3.05e-07 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 51.84 E-value: 3.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 8 IRRLMICSVTIVVSRAMTSPLLALWLSTRLGLNQQDIGLLMG-VAVFIATLMGLYGGYIIDRLEKRKLLILAMLSSSIGF 86
Cdd:cd17331 209 VAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSyAGVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGY 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 87 LLLTFASNLYLTTLTLVVTEAASALFLIGSKAIISENLPVGERAKVFSLRYTLTNVGYATGPMLGVVIAGQLPWAPFLIA 166
Cdd:cd17331 289 LLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLL 368
|
170
....*....|
gi 518655945 167 SAIAFGSLFL 176
Cdd:cd17331 369 GAAINGLLTV 378
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
37-378 |
7.19e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 50.68 E-value: 7.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 37 LGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRKLLILAMLSSSIGFLLLTFASNLYLTTLTLVVTEAASALFLIGS 116
Cdd:cd17316 31 LGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 117 KAIISENLPVGERAKVFSLRYTLTNVGYATGPMLGVVIAGQLPW-----APFLIASAIAFGSLFLMIgiaptqrddshkp 191
Cdd:cd17316 111 STYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGdwgwrILFLIGALPALLALLLRR------------- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 192 qsflstlrilrsdRTLILFTSGSLLSTIVHGrYTLYLSQFLLVA--YTPDQALKILSAVLACNAITVILMqyqiGRFLKR 269
Cdd:cd17316 178 -------------RTLLLILLWFFISFGYYG-LTTFLPTYLQTVlgLSPATSSLYLLLISLGALVGALIA----GLLSDR 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 270 EQLRHWIVLGTLLFIVGLVGFSQAHSLLTW--CLAMFVFTLGEMIIYPSEFLFIDTIAPDALRGSYYG-AQNLAAFGGAM 346
Cdd:cd17316 240 IGRKKTLVIGLILSGILALPLFYLLSGSPTllLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGlSYNLGRLGGGG 319
|
330 340 350
....*....|....*....|....*....|..
gi 518655945 347 SPVICGYLLINAAPTSMFFALAALTAMGGTLC 378
Cdd:cd17316 320 APPLIALLLASTGGTGVPALILALLAIVALIV 351
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
25-380 |
1.89e-06 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 49.54 E-value: 1.89e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 25 TSPLLALWLSTRLGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRKLLILAMLSSSIGFLLLTFASNLYLTTLTLVV 104
Cdd:cd17328 17 TIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 105 TEAASALFLIGSKAIISENLPVGERAKVFSLRYTLTNVGYATGPMLGVVIAGQLP---WApFLIASA--IAFGSLFLMI- 178
Cdd:cd17328 97 VGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGgwrWA-FRVTGVlgVLLAILLLLFv 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 179 -----GIAPTQRDDSHKPQSFLSTLRILRSDRTLILFTSGSLLSTIVHGRYTLYLSQFLLVAYTPDQALKIlSAVLACNA 253
Cdd:cd17328 176 repprGAAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDLSSA-DVGLIFGA 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 254 ITVI--LMQYQIGRFL---KREQLRHW-------IVLGTLLFIVGLVGFSQAHSLLTWCLAMFVFTLGEMIIYPSeFLFI 321
Cdd:cd17328 255 ITCIagVLGVLLGGILadrLRRKTPRAdplvcavGLLAAAPFLFLALVLALSNLLLAWVLLFLGEFLLSLNWAPV-FAIL 333
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518655945 322 DTIAPDALRGSYYGAQNL--AAFGGAMSPVICGYL--LINAAPTSMFFALAAL---------TAMGGTLCFL 380
Cdd:cd17328 334 LYVVIPTRRSTASAIQILlsHLLGDAGSPYLIGLIsdLLRQNKDSPLAEAASLqyalllcsfVLVLGGFFFL 405
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
1-383 |
2.68e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 49.08 E-value: 2.68e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 1 MATYSLVIRRLMICSVTIV--VSRAMTSPLLAlWLSTRLGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRKLLILA 78
Cdd:COG0738 1 MSKKNYRRALIAIYLLFFLwgFATALWGPLIP-ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 79 MLSSSIGFLLLTFASNLYLTTLTLVVTEAASALFLIGSKAIISEnLPVGERAKVFSLRYTLTNVGYATGPMLG-VVIAGQ 157
Cdd:COG0738 80 LLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAA-LGPETAASRLNLLHAFFSLGALLGPLLGgLLILLG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 158 LPWA---PFLIASAIAFGSLFLMIGIA-PTQRDDSHKPQSFLSTLRILRSDRTLILFTSGSLLSTIVHGRYTLYLSQFL- 232
Cdd:COG0738 159 LSLSwhlPYLILAVLLLLLALLFLRSKlPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLk 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 233 -LVAYTPDQALKILSAVLACNAITVILMqyqiGRFLKREQLRHWIVLGTLLFIVGLVGFSQAHSLLTWCLAMFVFTLGEM 311
Cdd:COG0738 239 dVLGLSEATAALGLSLFWGGMTIGRFLG----GFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLS 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 518655945 312 IIYPSEFLFIDTIAPD--ALRGSYYGAqnLAAFGGAMSPVICGYLlinAAPTSMFFALAALTAMGGTLCFLSGR 383
Cdd:COG0738 315 LMFPTIFSLALDGLGKrtAAAVSAVLI--MGIVGGAIGPPLIGFL---ADAFGLRAAFLVPLVCYLLILLLALA 383
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
27-379 |
2.71e-06 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 49.12 E-value: 2.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 27 PLLALWLsTRLGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRK-LLILAMLSSSIGFLLLTFASNLYLTTLTLVVt 105
Cdd:cd17335 18 PFLSVYL-KQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKaLLLLSLLAAVLFFLSLFFVAQIFWLLLLLVI- 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 106 eaasaLFLIGSKAI--ISENLpVGERAKVFSLRYTLTNVGYATGPMLGVVIAGQL---------PWAPFLIASAIAFGSL 174
Cdd:cd17335 96 -----LGAFFSAPVvpLVDSI-TLQYLGEERERYGKQRLWGSIGFGIAALLVGILidrsstyknYTIAFYVFAVLMLLAL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 175 FLMIGIAPtqRDDSHKPQSFLSTLRILRSDRTLILFTSGSLLSTIVHGRYTLYLSQFL-LVAYTPDqALKILSAVlacNA 253
Cdd:cd17335 170 LLALKFPF--RPKHPEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWHLqDLGGSKT-LIGLLWTV---GV 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 254 ITVILMQYQIGRFLKREQLRHWIVLGTLLFIVGLVGFSQAHSLLtWCLAMFV---FTLGemIIYPSEFLFIDTIAPDALR 330
Cdd:cd17335 244 VSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPW-LVLPIELlhgLTFA--LVWAAAVSYASAAAPPGLR 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 518655945 331 GSYYGAQNLAAFG--GAMSPVICGYLL--INAAPTSMFFALAALTAMGGTLCF 379
Cdd:cd17335 321 ATAQGLLQGLYFGlgGGLGSLIGGYLYeaFGARTTFRFFAIAALAGLLAFFLI 373
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
33-238 |
3.12e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 48.27 E-value: 3.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 33 LSTRLGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRKLLILAMLSSSIGFLLLTFASNLYLTTLTLVVTEAASALF 112
Cdd:COG0477 40 IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGL 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 113 LIGSKAIISENLPVGERAKVFSLRYTLTNVGYATGPMLGVVIAGQLPW-APFLIASAIAFGSLFLMIGIAPTQRDDSHKP 191
Cdd:COG0477 120 MPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWrWIFLINAPLGLLALVLRLRLPESRGLLLALL 199
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 518655945 192 QSFLSTLRILRSDRTLILFTSGSLLSTIVHGRYTLYLSQFLLVAYTP 238
Cdd:COG0477 200 ALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALL 246
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
9-182 |
3.72e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 48.74 E-value: 3.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 9 RRLMICSVTIVVSRAMTSPLLALWLSTRLGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRKLLILAMLSSSIGFLL 88
Cdd:COG2211 231 LLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLL 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 89 LTFA--SNLYLTTLTLVVTEAASALFLIGSKAIISENLPVGE-------RAKVFSLRYTLTNVGYATGPMLGVVIAGQLP 159
Cdd:COG2211 311 LFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEwktgrrrEGLYFGIFTFAIKLGQALAGALAGLLLALFG 390
|
170 180
....*....|....*....|...
gi 518655945 160 WAPFLIASAIAFGSLFLMIGIAP 182
Cdd:COG2211 391 YVAGAAQSPSALTGIRLLFFLLP 413
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
27-372 |
9.18e-06 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 47.23 E-value: 9.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 27 PLLALWLSTRLGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRKLLILAMLSSSIGFLLLTFASNLYLTTLTLVVTE 106
Cdd:cd17475 16 PALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 107 AASALFLIGSKAIISENLPVGERAKVFSLRYTLTNVGYATGPMLGVVIAGQLPW-APFLIASAIAFGS---LFLMIGIAP 182
Cdd:cd17475 96 AGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWrAAFVVAGLVSILAavlFWLFYREPP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 183 TQRDDSHKPQSFLSTLRILRSDRTLIL-FTSGSLLSTivhGRYTL--YLSQFLL--VAYTPDQALKILSAVLACNAITVI 257
Cdd:cd17475 176 AASAATESASTLLRSLKEVLRNRDVWLiAIAGALLVA---PQFALltFLLLFLHdhLGLSVVAAGALLAVAQLGGALGRI 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 258 LMQYQIGRFLKREQLR--HWIVLGTLLFIVGLVGFSQAHSLLTWCLAMFVFTLGEMIIYPSEFLFIDTIAPDALRGSYYG 335
Cdd:cd17475 253 GLGRVSDRVFGGRRRPvlVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALG 332
|
330 340 350
....*....|....*....|....*....|....*....
gi 518655945 336 AQNLAAFGGAMS-PVICGYLLINAA-PTSMFFALAALTA 372
Cdd:cd17475 333 LANTINFIGIAIgPPLFGLLVDATHsYAPAWLALALLLV 371
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
67-316 |
9.34e-06 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 47.19 E-value: 9.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 67 DRLEKRKLLILAMLSSSIGFLLLTFASNLYLTTLTLVVTEAASALFLIGSKAIISENLPVGERAKVFSLRYTLTNVGYAT 146
Cdd:cd17320 59 DRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPAL 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 147 GPMLGVVIAGQLPW-APFLIASAIAFGSLFLMIGIAPTQRDDSHKPQSFLSTLRILRSDRTLILFTSGSLLSTIVHGRYT 225
Cdd:cd17320 139 APLLGGLLLLFFGWrAIFVFLALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLF 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 226 LYL--SQFLLVA---YTPDQalkiLSAVLACNAITVILMQYQIGRFLKREQLRHWIVLGTLLFIVGLVG-----FSQAHS 295
Cdd:cd17320 219 AYLaaAPFIYIEqlgLSPAQ----FGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVlllaaLLGGLS 294
|
250 260
....*....|....*....|.
gi 518655945 296 LLTWCLAMFVFTLGEMIIYPS 316
Cdd:cd17320 295 LWPLVAPLFLIFFGFGLIFPN 315
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
10-180 |
9.71e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 47.22 E-value: 9.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 10 RLMICSVTIVVSRAMTSPLLALWLSTRLGLNQQDIGLLMGV-AVFIATLMGLYGGYIiDRLEKRKLLILAMLSSSIGFLL 88
Cdd:cd17329 204 LFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALnALLIVLLQFPVARLV-ERFRLRKILMIGILLFAIGFAV 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 89 LTFASNLYLTTLTLVVTEAASALFLIGSKAIISENLPVGERAKVFSLRYTLTNVGYATGPMLG-VVIAGQLPWAPFLIAS 167
Cdd:cd17329 283 LAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGgLLLDLLGPGLPWLILA 362
|
170
....*....|...
gi 518655945 168 AIAFGSLFLMIGI 180
Cdd:cd17329 363 ALGLIAAALLLGL 375
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
37-303 |
1.08e-05 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 46.85 E-value: 1.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 37 LGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRK-LLILAMLSSSI---GFLLLTFASNLYLTTLTLVVTEAASALF 112
Cdd:pfam12832 29 IGLNPSEIGLITAILPLTRILAPPIWGWLADRTGKRKaVVRLASILAAVlflSVLFIPISLTFWWLALLVVLFSFFWNAI 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 113 LIGSKAIISENLpvGERAKVFSLRYTLTNVGYA-----TGPMLGVVIAGQLPWAPFLIASAIAFGSLFLMigIAPTQRDD 187
Cdd:pfam12832 109 LPQFEVATLQHL--GEKRKDYGRQRLWGSVGFAlsvfgLGALFDHYSVGLLPSVLFYLFAALMLLSLLLP--LAPPEMEY 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 188 SHKPQSFLSTLRILRSDRTLILFTSGSLLST---IVHGRYTLYLSQfllVAYTPdqalKILSAVLACNAITVILMQYQIG 264
Cdd:pfam12832 185 ESKGGSKAVFWNLLKQPEVIIFFLAAFLLGFshgPFYTFLFLYLEN---LGASN----TLLGALWALGVVAEIPLFFYAH 257
|
250 260 270
....*....|....*....|....*....|....*....
gi 518655945 265 RFLKREQLRHWIVLGTLLFIVGLVGFSQAHSLLTWCLAM 303
Cdd:pfam12832 258 RLLRRFGHRNLLIIALLLTALRWLLYAFFVENPWLVLPI 296
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
37-151 |
1.52e-05 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 46.45 E-value: 1.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 37 LGLNQQDIGLLM----GVAVFIATLMGLYGgyiiDRLEKRKLLILAMLSSSIGFLLLTFASNLYLTTLTLVVTeaasALF 112
Cdd:cd17390 26 LGASPTVIGLIGsvygALQLFSSPLVGSWS----DVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPL----GIF 97
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 518655945 113 ---LIGSKAIISENLPVGERAKVFSLRYTLTNVGYATGPMLG 151
Cdd:cd17390 98 khtQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVG 139
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
11-175 |
2.60e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 45.72 E-value: 2.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 11 LMICSVTIVVSRAMTSPLLALWLSTrLGLNQQDI----GLLMGVAVFIATLMGLYGGYIIDRLEKRKLLILAMLSSSIGF 86
Cdd:cd17391 206 LFVTTFIIQLANQSIEPILTLYIRQ-LMGDASNLafisGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLY 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 87 LLLTFASNLYLTTLTLVVTEAASALFLIGSKAIISENLPVGERAKVFSLRYTLTNVGYATGPMLGVVIAGQLPW-APFLI 165
Cdd:cd17391 285 IPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYrAVFVV 364
|
170
....*....|
gi 518655945 166 ASAIAFGSLF 175
Cdd:cd17391 365 TALLVLLNAI 374
|
|
| PRK11646 |
PRK11646 |
multidrug efflux MFS transporter MdtH; |
11-346 |
3.05e-05 |
|
multidrug efflux MFS transporter MdtH;
Pssm-ID: 183255 Cd Length: 400 Bit Score: 45.82 E-value: 3.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 11 LMICSVTIVVSRAMTSPLLALWLSTRLGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRKLLILAMLSSSIGFLLLT 90
Cdd:PRK11646 15 LLIDNMLVVLGFFVVFPLISIRFVDQLGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 91 FASNLYLTTLTLVVTEAASALFLIGSKAIISENLPVGERAKVFSLRYTLTNVGYATGPMLG----------VVIAGQLpw 160
Cdd:PRK11646 95 IAHEPWLLWLSCILSGLGGTLFDPPRTALVIKLIRPHQRGRFFSLLMMQDSAGAVIGALLGswllqydfrlVCATGAV-- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 161 apfLIASAIAFGSLFLmigiaPTQRDDSHKPQSFLSTLRILRSDR--TLILFTSGS-LLSTIVHGRYTLYLSQfllVAYT 237
Cdd:PRK11646 173 ---LFVLAAAFNAWLL-----PAYKLSTVRTPVREGMTRVLRDKRfvTYVLTLTGYyMLAVQVMLMLPIMVND---IAGS 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 238 PdQALKILSAVLACNAITVIlmqYQIGRFL-KREQLRHWIVLGTLLFIVGLVGFSQAHSLLTWCLAMFVFTLGEMIIYPS 316
Cdd:PRK11646 242 P-SAVKWMYAIEACLSLTLL---YPIARWSeKRFRLEHRLMAGLLIMSLSMFPIGMVSNLQQLFTLICLFYIGSIIAEPA 317
|
330 340 350
....*....|....*....|....*....|.
gi 518655945 317 EFLFIDTIAPDALRGSYYGAQNLA-AFGGAM 346
Cdd:PRK11646 318 RETLSASLADARARGSYMGFSRLGlALGGAI 348
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
1-178 |
3.71e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 45.29 E-value: 3.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 1 MATYSLVIRRLMICSVTIVVSRAMTSPLLALWLST----RLGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRKLLI 76
Cdd:cd17316 168 PALLALLLRRRTLLLILLWFFISFGYYGLTTFLPTylqtVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLV 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 77 LAMLSSSIGFLLLTFA--SNLYLTTLTLVVTEAASALFLIGSKAIISENLPVGERAKVFSLRYTLTNVGYATGPMLGVVI 154
Cdd:cd17316 248 IGLILSGILALPLFYLlsGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALL 327
|
170 180
....*....|....*....|....*.
gi 518655945 155 AGQ--LPWAPFLIASAIAFGSLFLMI 178
Cdd:cd17316 328 LAStgGTGVPALILALLAIVALIVAL 353
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
51-372 |
3.86e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 45.24 E-value: 3.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 51 AVFIATLMgLYGGYIIDRLEKRKLLILAMLSSSIGFLLLTFASNLYLTTLTLVVTEAASALFLIGSKAIISENLPVGERA 130
Cdd:cd17321 41 LLAFAALL-LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRG 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 131 KVFSLRYTLTNVGYATGPMLGVVIAGQLPWAP-FLIASAIAFGSLFLMIGIAPTqrddshkpqsflstlrilrsdrTLIL 209
Cdd:cd17321 120 RALGLWGAVVGIGAALGPLLGGLLLELFGWRWiFLINVPIGLVALLLARTFSGA----------------------VLAA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 210 FTSGSLLSTIVhgrytLYLSQFLLVA--YTPDQAlkilSAVLACNAITVILMQYQIGRFLKREQLRHWIVLGTLLFIVGL 287
Cdd:cd17321 178 FLLGAALGGLL-----FLLPLYLQGVlgYSPLQA----GLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 288 VGFSQAHSLLTW---CLAMFVFTLGEMIIYPSEFLFIDTIAPDALRGSYYGAQNLA-----AFGGAMSPVICGYLLINAA 359
Cdd:cd17321 249 LLLALLGADSSVwllLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTArqlggALGVALLGALLTAGLSANL 328
|
330
....*....|...
gi 518655945 360 PTSMFFALAALTA 372
Cdd:cd17321 329 GDSGVAALLSAAA 341
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
33-372 |
5.08e-05 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 44.90 E-value: 5.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 33 LSTRLGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRKLLILAMLSSSIGFLLLTFASNLYLTTLTLVVTEAASAlf 112
Cdd:cd17331 26 LTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRLPSVFMHA-- 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 113 LIGSKAIISENLPVGERAKVF---SLRYTltnVGYATGPMLGVVIAGQL-PWAPFLIASAIAFGSL---FLMIGIAPTQR 185
Cdd:cd17331 104 MQAAQMVVTDLTDPGERAAALgrlGLSYG---IGMVVGSFLGGLLTKKFgEQAAALVAAVGSLLSIvlvILLIPSNTKSK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 186 DDSHKPQS----------FLSTLRILRSDRTLILFTSGSLLST-IVHGRYTLYLSQFLlvAYTPDQalkiLSAVLACNAI 254
Cdd:cd17331 181 REKEAKESasppsvfnlkEILRLLRLPGVAFLLLVKLLSGLPIgMFQSMFSLVAMDFF--GLTPEE----NGYLMSYAGV 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 255 TVILMQ-YQIGRFLKREQLRHWIVLGTLLFIVGLVGFSQAHSLLTWCLAMFVFTLGEMIIYPSEFLFIDTIAPDALRGSY 333
Cdd:cd17331 255 LGMVVQgLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTA 334
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 518655945 334 YG-AQNLAAFGGAMSPVICGYLLINAAPTSMFFALAALTA 372
Cdd:cd17331 335 LGlSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAING 374
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
67-171 |
8.42e-05 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 44.16 E-value: 8.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 67 DRLEKRKLLILAMLSSSIGFLLLTFASNLYLTTLTLVVTEAASALFLIGSkAIISENLPVGERAKVFSLRYTLTNVGYAT 146
Cdd:cd17388 63 DRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITGATGAVAA-AYIADVTPPEQRARNFGLLGAAFGLGFIA 141
|
90 100
....*....|....*....|....*
gi 518655945 147 GPMLGVVIAGQLPWAPFLIASAIAF 171
Cdd:cd17388 142 GPALGGLLGEISPRAPFLVAAGLNG 166
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
6-97 |
1.18e-04 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 43.69 E-value: 1.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 6 LVIRRLMICSVTIVVSRAMTSPLLALWLSTRLGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRKLLILAMLSSSIG 85
Cdd:cd17471 199 RRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLF 278
|
90
....*....|..
gi 518655945 86 FLLLTFASNLYL 97
Cdd:cd17471 279 YLGLALATSLWQ 290
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
24-380 |
2.79e-04 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 42.67 E-value: 2.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 24 MTSPLLALWLSTRLGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRKLLILAMLSSSIGFLLLTFASNLY-LTTLTL 102
Cdd:cd17371 16 LLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWqLLILRA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 103 VVTEAASALFLIGSkAIISENLPVGERAKVFSLRYTltnvGYATGPMLGVVIAGQL-PWAP--------FLIASAIAFGS 173
Cdd:cd17371 96 LAGLGFGGEWAAGA-ALMAEYVPARHRGKALGYVQS----GWAVGWLLATLLAALLfPLLPpeiawrvlFLLGALPALLV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 174 LFLMIGI--APTQRDDSHKPQSFL--STLRILRSDRTLILFTSGSLLSTIVHGRYtLYLSQFLLVAYTPDQALKILSAVL 249
Cdd:cd17371 171 LFIRRFVkePPQWQAARAARRHFAdrPSLRELFSPPLLRTTLLASLLATGALGGY-YGITTWLPSYLTGERGLSFEGSAG 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 250 ACNA-ITVILMQYQIGRFLKREQLRHWIV----LGTLLFIVGLVGFSQAHSLLTWCLAMFVFTLGemIIYPSEFLFIDTI 324
Cdd:cd17371 250 YLVVtILGGFLGYLAGGFLADRIGRRNNFalfaLGSAISILLYFFLPLSPTLILILGFPLGFFAS--GPFSGMGAYLTEL 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 518655945 325 APDALRGSYYG-AQNLAAFGGAMSPVICGYLL--INAAPTSMFFALAALTAMGGTLCFL 380
Cdd:cd17371 328 FPTAVRATAQGfCYNVGRIIGALFPFLVGFLAtsGSLGTAIAVFAAVYYIAGLVLALLL 386
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
29-178 |
3.66e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 42.17 E-value: 3.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 29 LALWLSTRLGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRL---EKRKLLILAMLSSSIGFLLLTFASNLYLTTLTLVVT 105
Cdd:cd17319 202 LPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrgARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLA 281
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 518655945 106 EAASALFLIGSKAIISENLPVGERAKVFSLRYTLTNVGYATGPML--GVVIAGQLPWAPFLIASAIAFGSLFLMI 178
Cdd:cd17319 282 GFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLigYLVDATGSYTAAFLFLAAVALLAALLVL 356
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
8-178 |
9.34e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 40.87 E-value: 9.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 8 IRRLMICSVTIVVSRAMTSPLLALWLSTRLGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRK-LLILAMLSSSIGF 86
Cdd:cd06174 205 LWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKpLLLIGLLLMALGL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 87 LLLTFASNLYLTTLTLVVTEAASALFLIGSKAIISENLPVGERAKVFSLRYTLTNVGYATGPMLGVVIAGQLPWAPFLIA 166
Cdd:cd06174 285 ALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFL 364
|
170
....*....|..
gi 518655945 167 SAIAFGSLFLMI 178
Cdd:cd06174 365 VLAVLLLLAAIL 376
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
245-380 |
1.54e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 40.34 E-value: 1.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 245 LSAVLACNAITVILMQYQIGRFLKREQLRHWIVLGTLLFIVGLVGFSQAHSLLTWCLAMFVFTLGEMIIYPSEFLFIDTI 324
Cdd:COG2814 47 AGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADL 126
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 518655945 325 APDALRGSYYGAQNLA-AFGGAMSPVICGYLLINAAPTSMFFALAALTAMGGTLCFL 380
Cdd:COG2814 127 VPPERRGRALGLLGAGlGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLR 183
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
37-170 |
1.74e-03 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 40.26 E-value: 1.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 37 LGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRKLLILAMLSSSIGFLLLTFASNLYLTTLTLVVTEAASALFLIGS 116
Cdd:cd17365 29 WGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNA 108
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 518655945 117 KAIISENLPVGERAKVFSLRYTLTNVGYATGPMLGVVIAGQLPWAPFLIASAIA 170
Cdd:cd17365 109 ITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVP 162
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
9-139 |
1.90e-03 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 40.05 E-value: 1.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 9 RRLMICSVTIVVSRAMTSPLLAL----WLSTRLGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRKLLI----LAML 80
Cdd:cd17368 221 RRIILLGMLLVAGSTVTFYFTTVytptYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLvitlAALV 300
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 518655945 81 SSSIGFLLLTFASNLYLTTLTLVVTEAASALFLIGSKAIISENLPVGERAKVFSLRYTL 139
Cdd:cd17368 301 TLYPVFAWLTAAPSFGRLLLVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYAL 359
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
12-158 |
2.95e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 39.46 E-value: 2.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 12 MICSVTIVVSRAMTSPLLALWLSTRLGLNQQDIGLLMGVAVFIATLMGLYGGYIIDRLEKRKLLILAMLSSSIGFLLLTF 91
Cdd:cd17321 174 VLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLAL 253
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 92 ---ASNLYLTTLTLVVTEAASALFLIGSKAIISENLPVGERAKVFSLRYTLTNVGYAtgpmLGVVIAGQL 158
Cdd:cd17321 254 lgaDSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGA----LGVALLGAL 319
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
44-182 |
3.38e-03 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 39.23 E-value: 3.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 44 IGLLMGVAVFiatlmglygGYIIDRLEKRKLLILAMLSSSIGFLLLTFASNLYLTTLTLVVTEAASALFLIGSKAIISEN 123
Cdd:TIGR00898 138 VGVLLGSFVF---------GYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEF 208
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 124 LPVGERAKVfslrYTLTNVGYATGPMLGVVIAGQLP-WAPFLIASAIAFGSLFLMIGIAP 182
Cdd:TIGR00898 209 LPKKQRAIV----GTLIQVFFSLGLVLLPLVAYFIPdWRWLQLAVSLPTFLFFLLSWFVP 264
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
44-346 |
6.62e-03 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 38.35 E-value: 6.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 44 IGLLMGVAVFIATLMGLYGGYIIDRLEKRKLLILAMLSSSIGFLLLTFASNLYlttlTLVVteaasALFLIGSKAI---- 119
Cdd:cd17472 34 IGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIY----GLIL-----GRALQGSGAIssvv 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 120 ---ISENLPVGERAKVFSLRYTLTNVGYATGPMLGVVIAGQLPW-APFLIASAIAFGSLFLMIGIAPTQRDDSHKPQSFL 195
Cdd:cd17472 105 malLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVsGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEK 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 196 STLRILRSDRTLILFTsgsLLSTIVHGRYTL--YLSQFLLV--AYTPDQALKILSAVLacnAITVILMQYQIGRFLKREQ 271
Cdd:cd17472 185 KKLKKLLKNKRLLRLD---FSIFILHFVLMAffYILPLLLTqlGGGKGQLWKVYLPAI---LIGFILMVPFVIYAEKKGK 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518655945 272 LRHWIVLGTLLFIVGLVGF-SQAHSLLTWCLAMFVFTLGEMIIYPSEFLFIDTIAPDALRGS----YYGAQNLAAFGGAM 346
Cdd:cd17472 259 MKQVFVSSILLIAVGFLLLlFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYRGTamgiYNTSQFLGSFLGGA 338
|
|
| |
