|
Name |
Accession |
Description |
Interval |
E-value |
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
6-601 |
0e+00 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 1021.22 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 6 FFRSIHFKLTLIYVLLIIVAMQIIGVYFVKQLEQSLINSYDNSLNQRIYSLSYYLEQDSSKSKAE---LKEDAQKILNDF 82
Cdd:NF033092 1 FFRSIHFKIVLIYVLLILIAMQIIGVYFVRQLETQLLNNFKESINLRANLLSYNLEQELSKEDEDdetLEEDIRTILNDF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 83 NNkdesNEISEVSYIDESREVIASVNNGSQEIAGKKITDQIISRIFAVGKDYEKKFYDPESNKRVRISATAVKNENQETV 162
Cdd:NF033092 81 NN----NDISEIQVIDAKGTILGTSDPSNQSIVGQKTTDSDVKRALLGGKDNEKILIDPEDNNRVYVLATPIKSSNGEVV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 163 GVIYVVSSMESVFNQMRTINTILATGTLIALGTTALLGIFIFRTITHPISDMRKQAIELAKGNFSRKVRKYGHDEIGQLA 242
Cdd:NF033092 157 GAIYIEASMESVYDQMNNINLIFATGTLIALVITAVLGILLARTITRPIKEMRKQALAMAKGDFSRKVKVYGNDEIGQLA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 243 TTFNHLTRELEEAQLMTEGERKKLSSVIAYMTDGVIATNQNGAIILLNSPALELLNVSRETALEMPITSLLGLEETHTFE 322
Cdd:NF033092 237 EAFNNLTKRLQEAQATTESERRKLDSVLSHMTDGVIATDRRGRVILINDPALEMLNVSRETVLGQSILDVLGLEEEYTLR 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 323 DLVENQDSMLLEIEREDQLSVLRVNFSVIQKEHGKIDGLIAVIYDVTEQEKIDAERREFVANVSHELRTPLTTMRSYLEA 402
Cdd:NF033092 317 DLLEEQDSLLLDFSTEEEPLILRANFSVIQRESGFINGLIAVLHDVTEQEKIEQERREFVANVSHELRTPLTTMRSYLEA 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 403 LAEGAIGDKELAPRFLSVTQNETERMIRLVNDLLQLSKFDSKDYQFNREWTNFIRFISLVIDRFEM-TKEQHVDFIRNLP 481
Cdd:NF033092 397 LADGAWKDPELAPRFLGVTQNETERMIRLVNDLLQLSRMDSKDYKLNKEWVNFNEFFNYIIDRFEMiLKNKNITFKREFP 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 482 QREIYVEIDQDKITQVLDNIISNAMKYSPEGGHITFTvdLDEEKGLVLFSVKDEGIGIPKKDMDKIFERFYRVDKARTRK 561
Cdd:NF033092 477 KRDLWVEIDTDKITQVLDNIISNAIKYSPEGGTITFR--LLETHNRIIISISDQGLGIPKKDLDKIFDRFYRVDKARSRK 554
|
570 580 590 600
....*....|....*....|....*....|....*....|
gi 518573285 562 LGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTVTFTLPY 601
Cdd:NF033092 555 MGGTGLGLAIAKEVVEAHGGRIWAESEEGKGTTIYFTLPY 594
|
|
| HK_VicK |
NF033093 |
cell wall metabolism sensor histidine kinase VicK; This model describes the protein VicK (or ... |
220-611 |
7.72e-132 |
|
cell wall metabolism sensor histidine kinase VicK; This model describes the protein VicK (or WalK) as found in Streptococcus pneumoniae, This protein is shorter than the WalK of Staphylococcus aureus, although apparently is functionally similar. Compare to model NF033092 (HK_WalK). VicK is a sensor histidine kinase involved in regulating cell wall metabolism. Its two component system partner is the response regulatory VicR.
Pssm-ID: 467965 [Multi-domain] Cd Length: 448 Bit Score: 393.70 E-value: 7.72e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 220 ELAKGNFSRKVRKYGHDEIGQLATTFNHLTRELEEAQLMTEGERKKLSSVIAYMTDGVIATNQNGAIILLNSPALELLNV 299
Cdd:NF033093 50 DLIAGDYSEVLDMQGDPELTELTNSLNDLSEVFRLTHENLEQEKNRLASILSYMTDGVLATNRRGQIIMINDTAQKQLNV 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 300 SRETALEMPITSLLGLEETHTFEDLVENQDSMLLEIERE-DQLSVLRVNFSVIQKEHGKIDGLIAVIYDVTEQEKIDAER 378
Cdd:NF033093 130 KREEALNMNILDLLDIDDEYDLRDLITKTPELTLDSRDEnGEFLSLRVRFALIRRESGFISGLVAVLHDTTEQEKEERER 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 379 REFVANVSHELRTPLTTMRSYLEALAEGAIgDKELAPRFLSVTQNETERMIRLVNDLLQLSKFDSKDYQFNREWTNFIRF 458
Cdd:NF033093 210 RLFVSNVSHELRTPLTSVKSYLEALDEGAL-SEPVAPSFIKVSLDETNRMMRMISDLLSLSRIDNQTSHLDVELTNFTAF 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 459 ISLVIDRFEMTKEQH------VDFIRNLPQREIYVEIDQDKITQVLDNIISNAMKYSPEGGHITFTVDLDEEKglVLFSV 532
Cdd:NF033093 289 ITFILNRFDQIKSQDtetgkkYEIVRDYPITSIWVEIDTDKMTQVIDNILNNAIKYSPDGGKITVSMKTTDTQ--LIISI 366
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 533 KDEGIGIPKKDMDKIFERFYRVDKARTRKLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTVTFTLPYNEE--QEDDWD 610
Cdd:NF033093 367 SDEGLGIPKKDLPLIFDRFYRVDKARSRAQGGTGLGLAIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDavKDDEWE 446
|
.
gi 518573285 611 E 611
Cdd:NF033093 447 D 447
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
286-604 |
1.22e-106 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 326.89 E-value: 1.22e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 286 IILLNSPALELLNVSRETALEMPITSLLGLEETHTFEDLVENQDSMLLEIEREDQLSVLRVNFSVIQKEHGKIDGLIAVI 365
Cdd:COG5002 73 LLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVE 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 366 YDVTEQEKIDAERREFVANVSHELRTPLTTMRSYLEALAEGAIGDKELAPRFLSVTQNETERMIRLVNDLLQLSKFDSKD 445
Cdd:COG5002 153 RDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGE 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 446 YQFNREWTNFIRFISLVIDRFEMT-KEQHVDFIRNLPQREIYVEIDQDKITQVLDNIISNAMKYSPEGGHITftVDLDEE 524
Cdd:COG5002 233 LKLEKEPVDLAELLEEVVEELRPLaEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTIT--VSLREE 310
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 525 KGLVLFSVKDEGIGIPKKDMDKIFERFYRVDKARTRKLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTVTFTLPYNEE 604
Cdd:COG5002 311 DDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLARE 390
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
179-606 |
1.01e-87 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 278.77 E-value: 1.01e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 179 RTINTILATGTLIALGTTALLGIFIFRTITHPISDMRKQAIELAKGNFSRKVRKYGHDEIGQLATTFNHLTRELEEAQLM 258
Cdd:COG5000 5 ILFLLLLLLIALLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKEQREE 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 259 TEGERKKLSSVIAYMTDGVIATNQNGAIILLNSPALELLNVSRETALEMPITSLLGLEETH-TFEDLVENQDSMLLEIER 337
Cdd:COG5000 85 LEERRRYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGKPLEELLPELDLAeLLREALERGWQEEIELTR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 338 EDQLsVLRVNFSVIQkehgkIDGLIAVIYDVTEQekIDAER----REFVANVSHELRTPLTTMRSYLE----ALAEGAIG 409
Cdd:COG5000 165 DGRR-TLLVRASPLR-----DDGYVIVFDDITEL--LRAERlaawGELARRIAHEIKNPLTPIQLSAErlrrKLADKLEE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 410 DKELAPRFLSVTQNETERMIRLVNDLLQLSKFDskdyQFNREWTNFIRFISLVIDRFEMT-KEQHVDFIRNLPQREIYVE 488
Cdd:COG5000 237 DREDLERALDTIIRQVDRLKRIVDEFLDFARLP----EPQLEPVDLNELLREVLALYEPAlKEKDIRLELDLDPDLPEVL 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 489 IDQDKITQVLDNIISNAMKYSPEGGHITFTVDLDEEKglVLFSVKDEGIGIPKKDMDKIFERFYrvdkarTRKLGGTGLG 568
Cdd:COG5000 313 ADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGR--VRIEVSDNGPGIPEEVLERIFEPFF------TTKPKGTGLG 384
|
410 420 430
....*....|....*....|....*....|....*...
gi 518573285 569 LAIAKEMVQAHGGDIWADSIEGKGTTVTFTLPYNEEQE 606
Cdd:COG5000 385 LAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAEEAE 422
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
370-604 |
2.17e-83 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 260.99 E-value: 2.17e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 370 EQEKIDAERREFVANVSHELRTPLTTMRSYLEALAEGAIGDKELAPRFLSVTQNETERMIRLVNDLLQLSKFDSKDYQFN 449
Cdd:COG2205 8 ELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLESGKLSLE 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 450 REWTNFIRFISLVIDRFEMT-KEQHVDFIRNLPQREIYVEIDQDKITQVLDNIISNAMKYSPEGGHItfTVDLDEEKGLV 528
Cdd:COG2205 88 LEPVDLAELLEEAVEELRPLaEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTI--TISARREGDGV 165
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518573285 529 LFSVKDEGIGIPKKDMDKIFERFYRVDkaRTRKLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTVTFTLPYNEE 604
Cdd:COG2205 166 RISVSDNGPGIPEEELERIFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAES 239
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
270-599 |
2.61e-76 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 245.97 E-value: 2.61e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 270 IAYMTDGVIATNQNGAIILLNSPALELLNVSRETALEMPITSLLG-------LEETHTFEDLVenqdsMLLEIEREDQLS 342
Cdd:TIGR02966 12 AQALPDAVVVLDEEGQIEWCNPAAERLLGLRWPDDLGQRITNLIRhpefveyLAAGRFSEPLE-----LPSPINSERVLE 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 343 VLRVNFSviqkehgkIDGLIAVIYDVTEQEKIDAERREFVANVSHELRTPLTTMRSYLEALAEGAIGDKELAPRFLSVTQ 422
Cdd:TIGR02966 87 IRIAPYG--------EEQKLLVARDVTRLRRLEQMRRDFVANVSHELRTPLTVLRGYLETLADGPDEDPEEWNRALEIML 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 423 NETERMIRLVNDLLQLSKFDSKDYQFNREWTNFIRFISLVIDRFEMT---KEQHVDFIrnlPQREIYVEIDQDKITQVLD 499
Cdd:TIGR02966 159 EQSQRMQSLVEDLLTLSRLESAASPLEDEPVDMPALLDHLRDEAEALsqgKNHQITFE---IDGGVDVLGDEDELRSAFS 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 500 NIISNAMKYSPEGGHITftVDLDEEKGLVLFSVKDEGIGIPKKDMDKIFERFYRVDKARTRKLGGTGLGLAIAKEMVQAH 579
Cdd:TIGR02966 236 NLVSNAIKYTPEGGTIT--VRWRRDGGGAEFSVTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRH 313
|
330 340
....*....|....*....|
gi 518573285 580 GGDIWADSIEGKGTTVTFTL 599
Cdd:TIGR02966 314 HARLEIESELGKGSTFSFIF 333
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
269-600 |
1.10e-75 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 244.43 E-value: 1.10e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 269 VIAYMTDGVIATNQNGAIILLNSPALELLNVSRETALEMPITSLLGLEETHTFEDLVENQDSMLLEIEREDQLSVLRVNF 348
Cdd:COG0642 1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 349 SVIQKEHGKIDGLIAVIYDVTEQEKIDAERREFVANVSHELRTPLTTMRSYLEALAEGAigdKELAPRFLSVTQNETERM 428
Cdd:COG0642 81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEEL---DEEQREYLETILRSADRL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 429 IRLVNDLLQLSKFDSKDYQFNREWTNFIRFISLVIDRFE-MTKEQHVDFIRNLPQREIYVEIDQDKITQVLDNIISNAMK 507
Cdd:COG0642 158 LRLINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRpLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIK 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 508 YSPEGGHITftVDLDEEKGLVLFSVKDEGIGIPKKDMDKIFERFYRVDKARTRklGGTGLGLAIAKEMVQAHGGDIWADS 587
Cdd:COG0642 238 YTPEGGTVT--VSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRG--GGTGLGLAIVKRIVELHGGTIEVES 313
|
330
....*....|...
gi 518573285 588 IEGKGTTVTFTLP 600
Cdd:COG0642 314 EPGKGTTFTVTLP 326
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
262-608 |
1.92e-62 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 210.47 E-value: 1.92e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 262 ERKKLSSVIAYMTDGVIATNQNGAIILLNSPALELLNVSRETALEMPITSLLGLEETHT--FEDLVENQDSML---LEIE 336
Cdd:COG3852 5 SEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFPEDSPLRelLERALAEGQPVTereVTLR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 337 REDQLSV-LRVNFSVIQKEHGKiDGLIAVIYDVTEQEKIDAERR---------EFVANVSHELRTPLTTMRSYLEALAEG 406
Cdd:COG3852 85 RKDGEERpVDVSVSPLRDAEGE-GGVLLVLRDITERKRLERELRraeklaavgELAAGLAHEIRNPLTGIRGAAQLLERE 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 407 AIGDKELapRFLSVTQNETERMIRLVNDLLQLSKFDskdyQFNREWTNFIRFISLVIDRFEMTKEQHVDFIRNLPQREIY 486
Cdd:COG3852 164 LPDDELR--EYTQLIIEEADRLNNLVDRLLSFSRPR----PPEREPVNLHEVLERVLELLRAEAPKNIRIVRDYDPSLPE 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 487 VEIDQDKITQVLDNIISNAMKYSPEGGHIT--------FTVDLDEEKGLVLFSVKDEGIGIPKKDMDKIFERFYrvdkar 558
Cdd:COG3852 238 VLGDPDQLIQVLLNLVRNAAEAMPEGGTITirtrverqVTLGGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFF------ 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 518573285 559 TRKLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTVTFTLPYNEEQEDD 608
Cdd:COG3852 312 TTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQAEEEP 361
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
158-604 |
3.34e-58 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 205.59 E-value: 3.34e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 158 NQETVGVIYVVSSMESVFNQM----RTINTILATGTLIALGTTALLgifiFRTITHPISDMrKQAIELAKGNFSRKVRKY 233
Cdd:PRK11360 165 NGEVIGYIWANELTEDIRRQAwkmdRRIYAVLAAGLVIGLLLIFLL----SRRFSANVDII-KDGLSTLENDLSTRLPPL 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 234 gHDEIGQLATTFNHLTRELEEAQLMTEgerkklsSVIAYMTDGVIATNQNGAIILLNSPALELLNVSRETALEMPITSLL 313
Cdd:PRK11360 240 -PGELGEISQAINNLAQALRETRSLNE-------LILESIADGVIAIDRQGKITTMNPAAEVITGLQRHELVGKPYSELF 311
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 314 G--------LEEThtfedLVENQDSMLLEIE--REDQLSVLRVNFSVIQKEHGKIDGLIAVIYDVTEQEKID-----AER 378
Cdd:PRK11360 312 PpntpfaspLLDT-----LEHGTEHVDLEISfpGRDRTIELSVSTSLLHNTHGEMIGALVIFSDLTERKRLQrrvarQER 386
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 379 R----EFVANVSHELRTPLTTMRSYLEALAEGAigDKELAPRFLSVTQNETERMIRLVNDLLQLSK-----FDSKDY-QF 448
Cdd:PRK11360 387 LaalgELVAGVAHEIRNPLTAIRGYVQIWRQQT--SDPPSQEYLSVVLREVDRLNKVIDQLLEFSRpresqWQPVSLnAL 464
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 449 NREWTNFIRfislvidrfEMTKEQHVDFIRNLPQREIYVEIDQDKITQVLDNIISNAMKYSPEGGHITFTVDLdEEKGLV 528
Cdd:PRK11360 465 VEEVLQLFQ---------TAGVQARVDFETELDNELPPIWADPELLKQVLLNILINAVQAISARGKIRIRTWQ-YSDGQV 534
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518573285 529 LFSVKDEGIGIPKKDMDKIFERFYrvdkarTRKLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTVTFTLPYNEE 604
Cdd:PRK11360 535 AVSIEDNGCGIDPELLKKIFDPFF------TTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINPQ 604
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
250-601 |
6.10e-52 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 185.95 E-value: 6.10e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 250 RELEEAQLMTEgerKKLSSVIAYMTDGVIATNQNGAIILLNSPALELLNVSRETALEMPITSLLGLEE----THTFEDLV 325
Cdd:COG5809 130 KRMEEALRESE---EKFRLIFNHSPDGIIVTDLDGRIIYANPAACKLLGISIEELIGKSILELIHSDDqenvAAFISQLL 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 326 ENQDSMLLEIE---REDQLSVLRVNFSVIqKEHGKIDGLIAVIYDVTEQEKIDAERR---------EFVANVSHELRTPL 393
Cdd:COG5809 207 KDGGIAQGEVRfwtKDGRWRLLEASGAPI-KKNGEVDGIVIIFRDITERKKLEELLRkseklsvvgELAAGIAHEIRNPL 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 394 TTMRSYLEALAEGAIGDKElapRFLSVTQNETERMIRLVNDLLQLSKFDSKDYQFNrewtNFIRFISLVIDRFEMTK-EQ 472
Cdd:COG5809 286 TSLKGFIQLLKDTIDEEQK---TYLDIMLSELDRIESIISEFLVLAKPQAIKYEPK----DLNTLIEEVIPLLQPQAlLK 358
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 473 HVDFIRNLPQREIYVEIDQDKITQVLDNIISNAMKYSPEGGHITFTVDLdEEKGLVLFSVKDEGIGIPKKDMDKIFERFY 552
Cdd:COG5809 359 NVQIELELEDDIPDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKA-EDDDKVVISVTDEGCGIPEERLKKLGEPFY 437
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 518573285 553 rvdkarTRKLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTVTFTLPY 601
Cdd:COG5809 438 ------TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPI 480
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
178-600 |
1.64e-49 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 179.60 E-value: 1.64e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 178 MRTINTILATGTLIALGTTALLGIFIFRTITHPISDMRKQAIELAKGNFSRKVRKYGHDEIGQLATTFNHLTRELEEAQL 257
Cdd:COG4251 75 LAALALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLL 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 258 MTEGERKKLSSVIAYMTDGVIATNQNGAIILLNSPALELLNVSRETALEMPITSLLGLEETHTFEDLVENQDSMLLEIER 337
Cdd:COG4251 155 LLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLL 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 338 EDQLSVLRVNFSVIQkEHGKIDGLIAVIYDVTEQ--------EKIDAERREFVANVSHELRTPLTTMRSYLEALAEgAIG 409
Cdd:COG4251 235 LVLLLLLILLLLLLI-LVLELLELRLELEELEEEleertaelERSNEELEQFAYVASHDLREPLRKISGFSQLLEE-DYG 312
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 410 DK--ELAPRFLSVTQNETERMIRLVNDLLQLSKFDSKDYQFnrEWTNFIRFISLVIDRFEMT-KEQHVDF-IRNLPQrei 485
Cdd:COG4251 313 DKldEEGREYLERIRDAAERMQALIDDLLAYSRVGRQELEF--EPVDLNELLEEVLEDLEPRiEERGAEIeVGPLPT--- 387
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 486 yVEIDQDKITQVLDNIISNAMKYSPEG--GHITFTVDldEEKGLVLFSVKDEGIGIPKKDMDKIFERFYRVDkaRTRKLG 563
Cdd:COG4251 388 -VRGDPTLLRQVFQNLISNAIKYSRPGepPRIEIGAE--REGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLH--SRDEYE 462
|
410 420 430
....*....|....*....|....*....|....*..
gi 518573285 564 GTGLGLAIAKEMVQAHGGDIWADSIEGKGTTVTFTLP 600
Cdd:COG4251 463 GTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLP 499
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
256-600 |
4.25e-45 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 165.57 E-value: 4.25e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 256 QLMTEGERKKLSSVI-------AYMTDGVIATNQNGAIILLNSPALELLNVSRETALEMPITSLLGLEEthtFEDLVENQ 328
Cdd:PRK11006 83 QLRNRKRRRELGNLIkrfrsgaESLPDAVVLTTEEGNIFWCNGLAQQLLGFRWPEDNGQNILNLLRYPE---FTQYLKTR 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 329 D-----SMLLEIERedqlsvlRVNFSVIQKEHGKidgLIAVIYDVTEQEKIDAERREFVANVSHELRTPLTTMRSYLEAL 403
Cdd:PRK11006 160 DfsrplTLVLNNGR-------HLEIRVMPYTEGQ---LLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMM 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 404 AEGAIgDKELAPRFLSVTQNETERMIRLVNDLLQLSKFD-SKDYQFNRewtnfirfislVIDRFEMTK--EQHVDFIRNl 480
Cdd:PRK11006 230 QDQPL-EGALREKALHTMREQTQRMEGLVKQLLTLSKIEaAPTIDLNE-----------KVDVPMMLRvlEREAQTLSQ- 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 481 PQREIYVEID--------QDKITQVLDNIISNAMKYSPEGGHITftVDLDEEKGLVLFSVKDEGIGIPKKDMDKIFERFY 552
Cdd:PRK11006 297 GKHTITFEVDnslkvfgnEDQLRSAISNLVYNAVNHTPEGTHIT--VRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFY 374
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 518573285 553 RVDKARTRKLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTVTFTLP 600
Cdd:PRK11006 375 RVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLP 422
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
8-600 |
1.06e-43 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 163.66 E-value: 1.06e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 8 RSIHFKLTLIYVLLIIVAMQIIGVYFVKQLEQSLinsYDNSLNQRIYSLSYYLEQDSSKSKAELKEDAQKILNDFNNKDE 87
Cdd:NF040691 3 RSLQLRVVAITLLLSLVVILVLGVVLALQITNGL---LDNRVDAALGDSRRARTQAQSQLNASDASTSDSAQQLLRTTLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 88 SNEISEVSYIDESREVIASVNNGSQEIAG----------KKITDQIISRifaVGKDYEKKFYdpesnKRVRISATAVKNE 157
Cdd:NF040691 80 SVLASASGAMQGAFDVVLLVPGDDPSGLGprasgsvglvSQIPEELREA---VAGGQVAQQY-----QSVALPSGDGSSA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 158 NQETVGV-----------IYVVSSMESVFNQMRTINTILATGTLIALGTTALLGIFIFRTITHPISDMRKQAIELAKGNF 226
Cdd:NF040691 152 PALVVGTpvtlpvagnyeLYLLFPLEDEQSTLALVRGTLLLGGLALVVLLGLIAWLVTRQVVAPVRSAARTAERFAAGDL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 227 SRKVRKYGHDEIGQLATTFNHLTreleeaqlmtegerkklssviaymtdgviatnqngaiillnspalellnvsretale 306
Cdd:NF040691 232 SERMPVKGEDDLARLARSFNQMA--------------------------------------------------------- 254
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 307 mpitsllgleethtfedlvenqDSMLLEIEREDQLSVLRvnfsviqkehgkidgliaviydvteqekidaerREFVANVS 386
Cdd:NF040691 255 ----------------------DSLQRQIRQLEELSRLQ---------------------------------QRFVSDVS 279
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 387 HELRTPLTTMRsyleaLAEGAIGDK--ELAP---RFLSVTQNETERMIRLVNDLLQLSKFDSKDYQFNREWTNFIRFISL 461
Cdd:NF040691 280 HELRTPLTTIR-----MAADVIHDSrdDFDPataRSAELLHTELDRFESLLSDLLEISRFDAGAAELDVEPVDLRPLVRR 354
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 462 VIDRFEMTKEQHVDFIR-NLPQREIYVEIDQDKITQVLDNIISNAMKYSpEGGHITFTVDLDEEKglVLFSVKDEGIGIP 540
Cdd:NF040691 355 VVDALRQLAERAGVELRvDAPGTPVVAEVDPRRVERVLRNLVVNAIEHG-EGKPVVVTVAQDDTA--VAVTVRDHGVGLK 431
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 541 KKDMDKIFERFYRVDKARTRKLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTVTFTLP 600
Cdd:NF040691 432 PGEVALVFDRFWRADPARARTTGGTGLGLAIALEDARLHGGWLEAWGRPGQGSQFRLTLP 491
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
253-600 |
2.95e-43 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 158.81 E-value: 2.95e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 253 EEAQLMTEGERKKLSSVIAYMTDGVIATNQNGAIILLNSPALELLNVSRETALEMPITSLLGLEETHTFEDLVENQDSML 332
Cdd:COG4191 2 LRLLLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 333 LEIEREDQLSVLRVnFSVIQKEHGKIDGLIAVIYDVTEQEKIDAERR----------------EFVANVSHELRTPLTTM 396
Cdd:COG4191 82 LGLLLLLLLEALLL-LLLAALDAEENAELEELERDITELERAEEELRelqeqlvqseklaalgELAAGIAHEINNPLAAI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 397 RSYLEALAE--GAIGDKELAPRFLSVTQNETERMIRLVNDLLQLSKFDSKDyqfnREWTNFIRFISLVIDRFE-MTKEQH 473
Cdd:COG4191 161 LGNAELLRRrlEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRDEEE----REPVDLNELIDEALELLRpRLKARG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 474 VDFIRNLPQREIYVEIDQDKITQVLDNIISNAMKYSPEGGHITFTVDLDEEKGLVLFSVKDEGIGIPKKDMDKIFERFYR 553
Cdd:COG4191 237 IEVELDLPPDLPPVLGDPGQLEQVLLNLLINAIDAMEEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFT 316
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 518573285 554 vdkarTRKLG-GTGLGLAIAKEMVQAHGGDIWADSIEGKGTTVTFTLP 600
Cdd:COG4191 317 -----TKPVGkGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLP 359
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
489-601 |
6.40e-41 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 144.33 E-value: 6.40e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 489 IDQDKITQVLDNIISNAMKYSPEGGHITFTVDLDEEKglVLFSVKDEGIGIPKKDMDKIFERFYRVDKaRTRKLGGTGLG 568
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDH--VEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLG 77
|
90 100 110
....*....|....*....|....*....|...
gi 518573285 569 LAIAKEMVQAHGGDIWADSIEGKGTTVTFTLPY 601
Cdd:smart00387 78 LSIVKKLVELHGGEISVESEPGGGTTFTITLPL 110
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
494-599 |
3.52e-40 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 141.97 E-value: 3.52e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 494 ITQVLDNIISNAMKYSPEGGHITFTVDLDEEKglVLFSVKDEGIGIPKKDMDKIFERFYRVDKARTRklGGTGLGLAIAK 573
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDG--VVLEVEDNGPGIPEEDLERIFERFYRGDKSREG--GGTGLGLAIVR 76
|
90 100
....*....|....*....|....*.
gi 518573285 574 EMVQAHGGDIWADSIEGKGTTVTFTL 599
Cdd:cd00075 77 RIVEAHGGRITVESEPGGGTTFTVTL 102
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
496-600 |
2.17e-39 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 139.94 E-value: 2.17e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 496 QVLDNIISNAMKYSPEGgHITFTVDLDEE---KGLVLFSVKDEGIGIPKKDMDKIFERFYRVDKARTRKLGGTGLGLAIA 572
Cdd:cd16922 3 QILLNLLGNAIKFTEEG-EVTLRVSLEEEeedGVQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAIS 81
|
90 100
....*....|....*....|....*...
gi 518573285 573 KEMVQAHGGDIWADSIEGKGTTVTFTLP 600
Cdd:cd16922 82 KKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
372-608 |
1.22e-38 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 148.24 E-value: 1.22e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 372 EKIDAERREFVANVSHELRTPLTTMRSYLEALAEGAigdKELAPRFLSVTQNETERMIRLVNDLLQLSKFDSKDYQFNRE 451
Cdd:PRK10549 234 EKNEQMRRDFMADISHELRTPLAVLRGELEAIQDGV---RKFTPESVASLQAEVGTLTKLVDDLHQLSLSDEGALAYRKT 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 452 WTNFIRFISLVI----DRFEmTKEQHVDFirNLPQrEIYVEIDQDKITQVLDNIISNAMKYSPEGGHITFTVDLDEEKGL 527
Cdd:PRK10549 311 PVDLVPLLEVAGgafrERFA-SRGLTLQL--SLPD-SATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLR 386
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 528 VLFsvKDEGIGIPKKDMDKIFERFYRVDKARTRKLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTVTFTLPYNEEQED 607
Cdd:PRK10549 387 LTF--ADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERDLQR 464
|
.
gi 518573285 608 D 608
Cdd:PRK10549 465 E 465
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
371-600 |
2.58e-38 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 145.48 E-value: 2.58e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 371 QEKIDAERReFVANVSHELRTPLTTMRSYLEALAEGAIG-DKELAP----RFLSVTQNETERMIRLVNDLLQLSKFDSKD 445
Cdd:PRK09303 145 LEQLKFKDR-VLAMLAHDLRTPLTAASLALETLELGQIDeDTELKPalieQLQDQARRQLEEIERLITDLLEVGRTRWEA 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 446 YQFNREWTNFIRFISLVIDRFEMT-KEQHVDFIRNLPQREIYVEIDQDKITQVLDNIISNAMKYSPEGGHITFTVdLDEE 524
Cdd:PRK09303 224 LRFNPQKLDLGSLCQEVILELEKRwLAKSLEIQTDIPSDLPSVYADQERIRQVLLNLLDNAIKYTPEGGTITLSM-LHRT 302
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518573285 525 KGLVLFSVKDEGIGIPKKDMDKIFERFYRVDkaRTRKLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTVTFTLP 600
Cdd:PRK09303 303 TQKVQVSICDTGPGIPEEEQERIFEDRVRLP--RDEGTEGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTLP 376
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
284-600 |
2.48e-36 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 141.50 E-value: 2.48e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 284 GAIILLNSPALELLnVSRetALEMPITSLLglEETHtfeDLVENQDSMLLEIEREDQLSVLRVNFSviqkehgkidgLIA 363
Cdd:NF012163 170 VALALLLAALAAFL-LAR--GLLAPVKRLV--EATH---RLAAGDYTTRVTPTSNDELGKLAQDFN-----------QLA 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 364 VIYDVTEQEkidaeRREFVANVSHELRTPLTTMRSYLEALAEGAigdKELAPRFLSVTQNETERMIRLVNDLLQLSKFDS 443
Cdd:NF012163 231 STLEKNEQM-----RRDFMADISHELRTPLAVLRAELEAIQDGI---RKFTPESLDSLQAEVGTLTKLVDDLHDLSMSDE 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 444 KDYQFNREWTNFIRFISLVIDRFEMTKEQ-----HVDfirnLPQREIYVEiDQDKITQVLDNIISNAMKYSPEGGHITFT 518
Cdd:NF012163 303 GALAYQKASVDLVPLLEVEGGAFRERFASaglelEVS----LPDSSLVFG-DRDRLMQLFNNLLENSLRYTDSGGSLHIS 377
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 519 VDlDEEKGLVLFsVKDEGIGIPKKDMDKIFERFYRVDKARTRKLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTVTFT 598
Cdd:NF012163 378 AS-QRPKEVTLT-VADSAPGVSDEQLARLFERFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTLHAAHSPLGGLRIVVT 455
|
..
gi 518573285 599 LP 600
Cdd:NF012163 456 LP 457
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
490-600 |
3.12e-36 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 131.34 E-value: 3.12e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 490 DQDKITQVLDNIISNAMKYSPEGGHITFTVDLDEEkglVLFSVKDEGIGIPKKDMDKIFERFYRVDKartRKLGGTGLGL 569
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAGEITVTLSEGGE---LTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGL 75
|
90 100 110
....*....|....*....|....*....|.
gi 518573285 570 AIAKEMVQAHGGDIWADSIEGKGTTVTFTLP 600
Cdd:pfam02518 76 SIVRKLVELLGGTITVESEPGGGTTVTLTLP 106
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
251-600 |
2.53e-35 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 139.48 E-value: 2.53e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 251 ELEEAQLMTEGERKKLSSVIAYMTDGVIATNQNGAIILLNSPALELLNVSRETALEMPITSLLGLEET----HTFEDLVE 326
Cdd:COG5805 144 KKKKIEEILQEQEERLQTLIENSPDLICVIDTDGRILFINESIERLFGAPREELIGKNLLELLHPCDKeefkERIESITE 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 327 NQDSMLLE---IEREDQLSVLRVNFSVIQKEHGKIDGLIAVIYDVTEQEKIDAERR---------EFVANVSHELRTPLT 394
Cdd:COG5805 224 VWQEFIIEreiITKDGRIRYFEAVIVPLIDTDGSVKGILVILRDITEKKEAEELMArseklsiagQLAAGIAHEIRNPLT 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 395 TMRSYLEALAEGAIGDKELAPRFLSvtqnETERMIRLVNDLLQLSKfdskDYQFNREWTNFIRFISLVIDRfeMTKE--- 471
Cdd:COG5805 304 SIKGFLQLLQPGIEDKEEYFDIMLS----ELDRIESIISEFLALAK----PQAVNKEKENINELIQDVVTL--LETEail 373
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 472 QHVDFIRNLPQREIYVEIDQDKITQVLDNIISNAMKYSPEGGHITFTVDLDEEKglVLFSVKDEGIGIPKKDMDKIFERF 551
Cdd:COG5805 374 HNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNS--VIIRVIDEGIGIPEERLKKLGEPF 451
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 518573285 552 YrvdkarTRKLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTVTFTLP 600
Cdd:COG5805 452 F------TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
375-600 |
2.78e-34 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 135.59 E-value: 2.78e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 375 DAERR--EFVANVSHELRTPLTTMRSYLE-ALAEGAIGD--KELaprfLSVTQNETERMIRLVNDLLQLSKFDSKDYQFN 449
Cdd:TIGR01386 236 DAFQRlsQFSADLAHELRTPLTNLLGQTQvALSQPRTGEeyREV----LESNLEELERLSRMVSDMLFLARADNGQLALE 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 450 REWTNFIRFISLVIDRFEMTKEQHVdfIRNLPQREIYVEIDQDKITQVLDNIISNAMKYSPEGGHITftVDLDEEKGLVL 529
Cdd:TIGR01386 312 RVRLDLAAELAKVAEYFEPLAEERG--VRIRVEGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTIT--VRIERRSDEVR 387
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 518573285 530 FSVKDEGIGIPKKDMDKIFERFYRVDKARTRKLGGTGLGLAIAKEMVQAHGGDIWADSIEGKgTTVTFTLP 600
Cdd:TIGR01386 388 VSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDGK-TRFILRFP 457
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
295-600 |
2.65e-32 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 133.36 E-value: 2.65e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 295 ELLNVSRETALEMPItslLGLEETHTFEDLVENQDSMLLEIE-REDQLSVLRVNFSVIQKEHGKIDgliaviydvTEQEK 373
Cdd:TIGR02956 392 RAIEAFRDTAAHNLK---LQADERQVAQELQEHKESLEQLVAqRTQELAETNERLNAEVKNHAKAR---------AEAEE 459
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 374 IDAERREFVANVSHELRTPLTTMRSYLEALaegaiGDKELAP---RFLSVTQNETERMIRLVNDLLQLSKFDSKDYQFNR 450
Cdd:TIGR02956 460 ANRAKSAFLATMSHEIRTPLNGILGTLELL-----GDTGLTSqqqQYLQVINRSGESLLDILNDILDYSKIEAGHLSISP 534
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 451 EWTNFIRFISLVIDRFEMTKEQ-----HVDFIRNLPQreiYVEIDQDKITQVLDNIISNAMKYSPEgGHITFTVDLDEEk 525
Cdd:TIGR02956 535 RPFDLNALLDDVHHLMVSRAQLkgiqlRLNIPEQLPN---WWQGDGPRIRQVLINLVGNAIKFTDR-GSVVLRVSLNDD- 609
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 518573285 526 GLVLFSVKDEGIGIPKKDMDKIFERFYRVDKarTRKLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTVTFTLP 600
Cdd:TIGR02956 610 SSLLFEVEDTGCGIAEEEQATLFDAFTQADG--RRRSGGTGLGLAISQRLVEAMDGELGVESELGVGSCFWFTLP 682
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
494-600 |
5.67e-32 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 119.35 E-value: 5.67e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 494 ITQVLDNIISNAMKYSPEGGHITFTVDldeeKGLVLFSVKDEGIGIPKKDMDKIFERFYRVDKARTRKLGGTGLGLAIAK 573
Cdd:cd16949 1 LARALENVLRNALRYSPSKILLDISQD----GDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAE 76
|
90 100
....*....|....*....|....*..
gi 518573285 574 EMVQAHGGDIWADSIEGKGTTVTFTLP 600
Cdd:cd16949 77 RAIEQHGGKIKASNRKPGGLRVRIWLP 103
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
371-600 |
8.77e-31 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 125.43 E-value: 8.77e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 371 QEKIDAERReFVANVSHELRTPLTTMRSYLeALAEGAIGD-KELApRFlsvtQNETERMIRLVNDLLQLSKFDSKDyQFN 449
Cdd:PRK09470 237 ERMMTSQQR-LLSDISHELRTPLTRLQLAT-ALLRRRQGEsKELE-RI----ETEAQRLDSMINDLLVLSRNQQKN-HLE 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 450 REWTNFIRFISLVID--RFEMtkEQ-HVDFIRNLPQREIYVEIDQDKITQVLDNIISNAMKYSPEGGHITFTVDldeEKG 526
Cdd:PRK09470 309 RETFKANSLWSEVLEdaKFEA--EQmGKSLTVSAPPGPWPINGNPNALASALENIVRNALRYSHTKIEVAFSVD---KDG 383
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 518573285 527 LVLfSVKDEGIGIPKKDMDKIFERFYRVDKARTRKLGGTGLGLAIAKEMVQAHGGDIWA-DSIEGkGTTVTFTLP 600
Cdd:PRK09470 384 LTI-TVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAeDSPLG-GLRLTIWLP 456
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
356-608 |
2.40e-30 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 126.98 E-value: 2.40e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 356 GKIDGLIAVIYDVTE----QEKIDAERRE---FVANVSHELRTPLTtmrsylealaeGAIG------DKELAPRFLSVTQ 422
Cdd:PRK11091 254 GKRHGLMGFGRDITErkryQDALEKASRDkttFISTISHELRTPLN-----------GIVGlsrillDTELTAEQRKYLK 322
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 423 NETERMIRL---VNDLLQLSKFDSKDYQFNREWTNFIRFIS--------LVID---RFEMTKEQHvdfirnLPQreiYVE 488
Cdd:PRK11091 323 TIHVSAITLgniFNDIIDMDKMERRKLQLDNQPIDFTDFLAdlenlsglQAEQkglRFDLEPLLP------LPH---KVI 393
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 489 IDQDKITQVLDNIISNAMKYSPEGGhITFTVDLDEEKGLvLFSVKDEGIGIPKKDMDKIFERFYRV-DKARTRKLGGTGL 567
Cdd:PRK11091 394 TDGTRLRQILWNLISNAVKFTQQGG-VTVRVRYEEGDML-TFEVEDSGIGIPEDELDKIFAMYYQVkDSHGGKPATGTGI 471
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 518573285 568 GLAIAKEMVQAHGGDIWADSIEGKGT--TVTFTLPYNEEQEDD 608
Cdd:PRK11091 472 GLAVSKRLAQAMGGDITVTSEEGKGScfTLTIHAPAVAEEVED 514
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
381-600 |
3.26e-30 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 124.19 E-value: 3.26e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 381 FVANVSHELRTPLTTMRSYLEALAEGAIGDKelAPRFLSVTQNETERMIRLVNDLLQLSKFDSKDYQFNREWTNFIRFIS 460
Cdd:PRK11100 259 YVQTLTHELKSPLAAIRGAAELLQEDPPPED--RARFTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLE 336
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 461 LVIDRFEMTKEQHVDFIRNLPQrEIYVEIDQDKITQVLDNIISNAMKYSPEGGHITFTVDLDEEKglVLFSVKDEGIGIP 540
Cdd:PRK11100 337 ELVEAREAQAAAKGITLRLRPD-DARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQ--VALSVEDQGPGIP 413
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 518573285 541 KKDMDKIFERFY---RVDKARTrklgGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTVTFTLP 600
Cdd:PRK11100 414 DYALPRIFERFYslpRPANGRK----STGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLP 472
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
383-608 |
6.97e-30 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 122.97 E-value: 6.97e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 383 ANVSHELRTPLTTMRSYLEALAEGAIG---DKELAprflSVTQNETERMIRLVNDLLQLSKFDSKDYQFNReWTNFIRFI 459
Cdd:PRK10364 242 AGVAHEIRNPLSSIKGLAKYFAERAPAggeAHQLA----QVMAKEADRLNRVVSELLELVKPTHLALQAVD-LNDLINHS 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 460 SLVIDRFEMTKEQHVDFIRNLPQREIyvEIDQDKITQVLDNIISNAMKYSPEGGHITFTVdlDEEKGLVLFSVKDEGIGI 539
Cdd:PRK10364 317 LQLVSQDANSREIQLRFTANDTLPEI--QADPDRLTQVLLNLYLNAIQAIGQHGVISVTA--SESGAGVKISVTDSGKGI 392
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 518573285 540 PKKDMDKIFERFYrvdkarTRKLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTVTFTLPYNEEQEDD 608
Cdd:PRK10364 393 AADQLEAIFTPYF------TTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVNITRRDP 455
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
361-600 |
8.82e-30 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 122.96 E-value: 8.82e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 361 LIAVIYDV-TEQEKidaerreFVANVSHELRTPLTTMRSYLEALAEGAIGDKELAPRFLSVTQnETERMIRLVNDLLQLS 439
Cdd:PRK09835 251 MIERIEDVfTRQSN-------FSADIAHEIRTPITNLITQTEIALSQSRSQKELEDVLYSNLE-ELTRMAKMVSDMLFLA 322
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 440 KFDSKDYQFNREWTNFIRFISLVIDRFE-MTKEQHVDFirNLPQREIYVEIDQDKITQVLDNIISNAMKYSPEGGHITft 518
Cdd:PRK09835 323 QADNNQLIPEKKMLDLADEVGKVFDFFEaWAEERGVEL--RFVGDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAIT-- 398
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 519 VDLDEEKGLVLFSVKDEGIGIPKKDMDKIFERFYRVDKARTRKLGGTGLGLAIAKEMVQAHGGDIWADSiEGKGTTVTFT 598
Cdd:PRK09835 399 VRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTS-DARGTRFVIS 477
|
..
gi 518573285 599 LP 600
Cdd:PRK09835 478 LP 479
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
369-607 |
9.90e-28 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 118.99 E-value: 9.90e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 369 TEQEKIDAERRE----FVANVSHELRTPLTTMRSYLEAL-----AEG---AIGDKELAPRFLSVTqnetermiRLVNDLL 436
Cdd:PRK10490 651 EEQARLASEREQlrnaLLAALSHDLRTPLTVLFGQAEILtldlaSEGsphARQASEIRQQVLNTT--------RLVNNLL 722
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 437 QLSKFDSKDYQFNREWTNFIRFISLVIDRFEMTKEQHVDFIrNLPQREIYVEIDQDKITQVLDNIISNAMKYSpeGGHIT 516
Cdd:PRK10490 723 DMARIQSGGFNLRKEWLTLEEVVGSALQMLEPGLSGHPINL-SLPEPLTLIHVDGPLFERVLINLLENAVKYA--GAQAE 799
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 517 FTVDLDEEKGLVLFSVKDEGIGIPKKDMDKIFERFYRVDKARTrkLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTVT 596
Cdd:PRK10490 800 IGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESA--IPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFR 877
|
250
....*....|....*..
gi 518573285 597 FTLPYN------EEQED 607
Cdd:PRK10490 878 VTLPLEtppeleEFHED 894
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
500-600 |
3.23e-27 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 106.13 E-value: 3.23e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 500 NIISNAMKYSPEGGHITFTVDLDEEKGLvlFSVKDEGIGIPKKDMDKIFERFYRVDKARTRKLGGTGLGLAIAKEMVQAH 579
Cdd:cd16952 7 NLVSNAVKYTPPSDTITVRWSQEESGAR--LSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVMSRH 84
|
90 100
....*....|....*....|.
gi 518573285 580 GGDIWADSIEGKGTTVTFTLP 600
Cdd:cd16952 85 DARLLIASELGKGSRFTCLFP 105
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
494-600 |
3.40e-26 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 102.79 E-value: 3.40e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 494 ITQVLDNIISNAMKYSPEGGHITFTVDLDEEKGLVLFSVKDEGIGIPKKDMDKIFERFYRVDKarTRKLGGTGLGLAIAK 573
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHS--REEYEGTGVGLAIVR 78
|
90 100
....*....|....*....|....*..
gi 518573285 574 EMVQAHGGDIWADSIEGKGTTVTFTLP 600
Cdd:cd16921 79 KIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
376-600 |
1.62e-25 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 109.69 E-value: 1.62e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 376 AERREFVANVSHELRTPLTTMRsYLEALAEGAIGDKELA-PRflSVTQNETermirLVNDLLQLSKFDSKDYQFNREWTN 454
Cdd:PRK10604 210 ASKKQLIDGIAHELRTPLVRLR-YRLEMSDNLSAAESQAlNR--DIGQLEA-----LIEELLTYARLDRPQNELHLSEPD 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 455 FIRFISLVIDRFE-MTKEQHVDFirNLPQREIYVEIDQDKITQVLDNIISNAMKYSpeggHITFTVDLDEEKGLVLFSVK 533
Cdd:PRK10604 282 LPAWLSTHLADIQaVTPEKTVRL--DTPHQGDYGALDMRLMERVLDNLLNNALRYA----HSRVRVSLLLDGNQACLIVE 355
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518573285 534 DEGIGIPKKDMDKIFERFYRVDKARTRKLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTVTFTLP 600
Cdd:PRK10604 356 DDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWP 422
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
490-600 |
1.63e-25 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 101.00 E-value: 1.63e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 490 DQDKITQVLDNIISNAMKYSPEGGhiTFTVDLDEEKGLVLFSVKDEGIGIPKKDMDKIFERFYRVDKARTRKLGGTGLGL 569
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGG--KLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGL 78
|
90 100 110
....*....|....*....|....*....|.
gi 518573285 570 AIAKEMVQAHGGDIWADSIEGKGTTVTFTLP 600
Cdd:cd16946 79 AICHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
367-600 |
3.99e-25 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 110.98 E-value: 3.99e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 367 DVTEQEKIDAE--RREFVANVSHELRTPLTTMRSYLEALAeGAIGDKELAPRFLSVTQNETERMIRLVNDLLQLSKFDSK 444
Cdd:PRK09959 699 EVERNKAINATvaKSQFLATMSHEIRTPISSIMGFLELLS-GSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESG 777
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 445 DYQFNREWTNFIRFISLVIDRF---EMTKEQHVDFIRNLPQREIyVEIDQDKITQVLDNIISNAMKYSPEGGH--ITFTV 519
Cdd:PRK09959 778 NYQLQPQWVDIPTLVQNTCHSFgaiAASKSIALSCSSTFPDHYL-VKIDPQAFKQVLSNLLSNALKFTTEGAVkiTTSLG 856
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 520 DLDEEKGLVLFSVKDEGIGIPKKDMDKIFERFYRVDKARTRKlgGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTVTFTL 599
Cdd:PRK09959 857 HIDDNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQT--GSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITI 934
|
.
gi 518573285 600 P 600
Cdd:PRK09959 935 P 935
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
383-583 |
4.78e-25 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 107.00 E-value: 4.78e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 383 ANVSHELRTPLTTMRSYLEALAEGA-IGDKELAPRFLsvtqNETERMIRLVNDLLQLSKFDSKDYQFNREWTNFIRFISL 461
Cdd:NF012226 143 AAIAHELRTPITILQGRLQGILDGVfEPDPALFKSLL----NQVEGLSHLVEDLRTLSLVENQQLRLNYESVDLKDSIEK 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 462 VIDRFEmTKEQHVDFIRNLPQREIYVEIDQDKITQVLDNIISNAMKYSpEGGHITFTVDLDEEKgLVLfSVKDEGIGIPK 541
Cdd:NF012226 219 VLKMFE-DRLEQAQLTIVLNLTATPVFCDRRRIEQVLIALIDNAIRYA-NAGKLKISSSVIQDD-WIL-QIEDEGPGIAE 294
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 518573285 542 KDMDKIFERFYRVDKARTRKLGGTGLGLAIAKEMVQAHGGDI 583
Cdd:NF012226 295 EYQQDLFNPFFRLEQSRNKEFGGTGLGLAVVHAIVIAHKGSI 336
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
490-600 |
1.29e-24 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 98.72 E-value: 1.29e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 490 DQDKITQVLDNIISNAMKYSPEGGHITFTVDLDEEKGlVLFSVKDEGIGIPKKDMDKIFERFYRVDKARTRKLGGTGLGL 569
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFRLNR-FLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGL 79
|
90 100 110
....*....|....*....|....*....|.
gi 518573285 570 AIAKEMVQAHGGDIWADSIEGKGTTVTFTLP 600
Cdd:cd16925 80 SIVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
238-604 |
5.53e-24 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 104.16 E-value: 5.53e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 238 IGQLATTFNHLTRELEEAQLMTEGERKKLSSVIAYMTDGVIATNQNGAIILLNSPALELLNVSretalempitsLLGLEE 317
Cdd:COG3290 58 LILLLLLLLLLAALLLKLLEEIARLVEEREAVLESIREGVIAVDRDGRITLINDAARRLLGLD-----------AIGRPI 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 318 THTFEDLVENQDSMLLEIEREDQLSVLRVNFSViqkeHGKIDGLIAVIYDVTEQEKIDAE---RREFVANV---SHELRT 391
Cdd:COG3290 127 DEVLAEVLETGERDEEILLNGRVLVVNRVPIRD----DGRVVGAVATFRDRTELERLEEElegVKELAEALraqRHDFRN 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 392 PLTTMRSYLEalaegaIGDKELAPRFLsvtQNETERMIRLVNDLLQLSKFDSKDyqfnrewtnfirfiSLVIDRFEMTKE 471
Cdd:COG3290 203 HLHTISGLLQ------LGEYDEALEYI---DEISEELQELIDSLLSRIGNPVLA--------------ALLLGKAARARE 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 472 QHVDFIRNLPQREIYVEIDQDKITQVLDNIISNAMKY--SPEGGHITFTVDLDEEKGLVLFSVKDEGIGIPKKDMDKIFE 549
Cdd:COG3290 260 RGIDLTIDIDSDLPDLPLSDTDLVTILGNLLDNAIEAveKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFE 339
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 518573285 550 RFYRvdkarTRKLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTVTFTLPYNEE 604
Cdd:COG3290 340 RGFS-----TKLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEGE 389
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
371-581 |
8.06e-24 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 103.12 E-value: 8.06e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 371 QEKIDAERrEFVANVSHELRTPLTTMRSYLEALAE-GAIGDKELAPRFlsvtqnetERMIRLVNDLLQLS----KFDSKD 445
Cdd:PRK10755 131 TSTLDQER-LFTADVAHELRTPLAGIRLHLELLEKqHHIDVAPLIARL--------DQMMHTVEQLLQLAragqSFSSGH 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 446 YQfNREWTNFIrfISLVIDRF-EMTKEQHVDFIRNLPQREIYVEIDQDKITQVLDNIISNAMKYSPEGGHItfTVDLDEE 524
Cdd:PRK10755 202 YQ-TVKLLEDV--ILPSQDELsEMLEQRQQTLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTI--TIKLSQE 276
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 518573285 525 KGLVLFSVKDEGIGIPKKDMDKIFERFYRVDkartRKLGGTGLGLAIAKEMVQAHGG 581
Cdd:PRK10755 277 DGGAVLAVEDEGPGIDESKCGELSKAFVRMD----SRYGGIGLGLSIVSRITQLHHG 329
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
497-600 |
3.13e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 91.96 E-value: 3.13e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 497 VLDNIISNAMKYSPEGGHITFTVDLDEEKglVLFSVKDEGIGIPKKDMDKIFERFYRVDKARtRKLGGTGLGLAIAKEMV 576
Cdd:cd16948 9 IIGQIVSNALKYSKQGGKIEIYSETNEQG--VVLSIKDFGIGIPEEDLPRVFDKGFTGENGR-NFQESTGMGLYLVKKLC 85
|
90 100
....*....|....*....|....
gi 518573285 577 QAHGGDIWADSIEGKGTTVTFTLP 600
Cdd:cd16948 86 DKLGHKIDVESEVGEGTTFTITFP 109
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
482-596 |
3.88e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 91.70 E-value: 3.88e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 482 QREIYVEIDQDKITQVLDNIISNAMKYSPEGGHITFTVdldEEKGLVLFSVKDEGIGIPKKDMDKIFERFYRVDKartRK 561
Cdd:cd16940 2 AADIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKL---SADDGAVIRVEDNGPGIDEEELEALFERFYRSDG---QN 75
|
90 100 110
....*....|....*....|....*....|....*
gi 518573285 562 LGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTVT 596
Cdd:cd16940 76 YGGSGLGLSIVKRIVELHGGQIFLGNAQGGGLEAW 110
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
381-600 |
5.01e-22 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 101.20 E-value: 5.01e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 381 FVANVSHELRTPLttmrsYlealaeGAIGDKEL---------APRFLSVTQNETERMIRLVNDLLQLSKFDSKDY----- 446
Cdd:PRK10841 450 FLATVSHELRTPL-----Y------GIIGNLDLlqtkelpkgVDRLVTAMNNSSSLLLKIISDILDFSKIESEQLkiepr 518
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 447 QFN-REWTNFI--RFISLVIDRfemtkeqhvdfirnlpQREIYVEIDQD----------KITQVLDNIISNAMKYSPEGG 513
Cdd:PRK10841 519 EFSpREVINHItaNYLPLVVKK----------------RLGLYCFIEPDvpvalngdpmRLQQVISNLLSNAIKFTDTGC 582
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 514 hITFTVDLDEekGLVLFSVKDEGIGIPKKDMDKIFERFYRVDKARTRKLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGT 593
Cdd:PRK10841 583 -IVLHVRVDG--DYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMDGDISVDSEPGMGS 659
|
....*..
gi 518573285 594 TVTFTLP 600
Cdd:PRK10841 660 QFTIRIP 666
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
379-600 |
7.55e-22 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 100.20 E-value: 7.55e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 379 REFVANVSHELRTPLTTMRSYLEALAEGAigDKELAPRFLSVTQNETERMIRLVNDLLQLSKFDSKDYQFNREWTNFIRF 458
Cdd:TIGR03785 486 ENMSSRLSHELRTPVAVVRSSLENLELQA--LEQEKQKYLERAREGTERLSMILNNMSEATRLEQAIQSAEVEDFDLSEV 563
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 459 ISLVIDRFEMTKEqHVDFIRNLPQREIYVEIDQDKITQVLDNIISNAMKYSPEGGHItfTVDLDEEKGLVLFSVKDEGIG 538
Cdd:TIGR03785 564 LSGCMQGYQMTYP-PQRFELNIPETPLVMRGSPELIAQMLDKLVDNAREFSPEDGLI--EVGLSQNKSHALLTVSNEGPP 640
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 518573285 539 IPKKDMDKIFERFYRVDKARTRKLGGTGLGLAIAKEMVQAHGGDIWADSI-EGKGTTVTFTLP 600
Cdd:TIGR03785 641 LPEDMGEQLFDSMVSVRDQGAQDQPHLGLGLYIVRLIADFHQGRIQAENRqQNDGVVFRISLP 703
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
370-606 |
1.18e-21 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 99.72 E-value: 1.18e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 370 EQEKIDAERREFVANVSHELRTPLTTMRSYLEALAEGAIGDKELapRFLSVTQNETERMIRLVNDLLQLSKFDSKDYQFN 449
Cdd:PRK15347 390 RAEQANKRKSEHLTTISHEIRTPLNGVLGALELLQNTPLTAEQM--DLADTARQCTLSLLAIINNLLDFSRIESGQMTLS 467
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 450 REWTNfirfISLVIDRFEMTKEQHVD--------FI-RNLPQreiYVEIDQDKITQVLDNIISNAMKYSPEGgHITFTVD 520
Cdd:PRK15347 468 LEETA----LLPLLDQAMLTIQGPAQsksltlrtFVgAHVPL---YLHLDSLRLRQILVNLLGNAVKFTETG-GIRLRVK 539
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 521 LDEEKglVLFSVKDEGIGIPKKDMDKIFERFYRVDKartrKLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTVTFTLP 600
Cdd:PRK15347 540 RHEQQ--LCFTVEDTGCGIDIQQQQQIFTPFYQADT----HSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLP 613
|
....*.
gi 518573285 601 YNEEQE 606
Cdd:PRK15347 614 LNEYAP 619
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
380-601 |
5.02e-21 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 95.70 E-value: 5.02e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 380 EFVANVSHELRTPLTTMRSYLEaLAEGAIGDKELAPRFLSVTQNETERMIRLVNDLLQLSKFDSKDYQ---FNREwtnfI 456
Cdd:COG5806 203 ELAASIAHEVRNPLTVVRGFIQ-LLQEPELSDEKRKQYIRIALEELDRAEAIITDYLTFAKPQPEKLEkidVSEE----L 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 457 RFISLVIDRFEMTkeQHVDfIRNLPQREIYVEIDQDKITQVLDNIISNAMKYSPEGGhiTFTVDLDEEKGLVLFSVKDEG 536
Cdd:COG5806 278 EHVIDVLSPYANM--NNVE-IQTELEPGLYIEGDRQKLQQCLINIIKNGIEAMPNGG--TLTIDVSIDKNKVIISIKDTG 352
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 518573285 537 IGIPKKDMDKIFERFYrvdkarTRKLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTVTFTLPY 601
Cdd:COG5806 353 VGMTKEQLERLGEPYF------STKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITLPL 411
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
497-600 |
5.03e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 88.21 E-value: 5.03e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 497 VLDNIISNAMKYSPEGGHITFTVDLDEEKglVLFSVKDEGIGIPKKDMDKIFERFYRVDKArtRKLGGTGLGLAIAKEMV 576
Cdd:cd16923 4 VFSNLLSNAIKYSPENTRIYITSFLTDDV--VNIMFKNPSSHPLDFKLEKLFERFYRGDNS--RNTEGAGLGLSIAKAII 79
|
90 100
....*....|....*....|....
gi 518573285 577 QAHGGDIWAdSIEGKGTTVTFTLP 600
Cdd:cd16923 80 ELHGGSASA-EYDDNHDLFKVRLP 102
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
479-599 |
6.44e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 88.72 E-value: 6.44e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 479 NLPQREIYVEIDQDKITQVLDNIISNAMKYSPEGGHITFTVDLDEEKglVLFSVKDEGIGIPKKDMDKIFERFYRVDKAR 558
Cdd:cd16947 6 NIPDRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKH--VYIDIWDKGKGISETEKDHVFERLYTLEDSR 83
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 518573285 559 TRKLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTVTFTL 599
Cdd:cd16947 84 NSAKQGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
380-600 |
8.26e-21 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 97.23 E-value: 8.26e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 380 EFVANVSHELRTPLTtmrsylealaeGAIG-DKELAPRFLSVTQ----NETER----MIRLVNDLLQLSKFDS-----KD 445
Cdd:PRK11107 295 EFLANMSHELRTPLN-----------GVIGfTRQTLKTPLTPTQrdylQTIERsannLLAIINDILDFSKLEAgklvlEN 363
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 446 YQFN-REwtnfirfislVIDrfE-MTKEQHVDFIRNLpqrEIYVEIDQD----------KITQVLDNIISNAMKYSpEGG 513
Cdd:PRK11107 364 IPFSlRE----------TLD--EvVTLLAHSAHEKGL---ELTLNIDPDvpdnvigdplRLQQIITNLVGNAIKFT-ESG 427
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 514 HITFTVDL---DEEKGLVLFSVKDEGIGIPKKDMDKIFERFYRVDKARTRKLGGTGLGLAIAKEMVQAHGGDIWADSIEG 590
Cdd:PRK11107 428 NIDILVELralSNTKVQLEVQIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQKLVNEMGGDISFHSQPN 507
|
250
....*....|
gi 518573285 591 KGTTVTFTLP 600
Cdd:PRK11107 508 RGSTFWFHLP 517
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
490-597 |
1.73e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 86.75 E-value: 1.73e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 490 DQDKITQVLDNIISNAMKYSPEGGHITFTVDLDEEkgLVLFSVKDEGIGIPKKDMDKIFERFYRVDKARTRKlGGTGLGL 569
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEE--YLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSG-GHYGMGL 77
|
90 100
....*....|....*....|....*...
gi 518573285 570 AIAKEMVQAHGGDIWADSIEGKGTTVTF 597
Cdd:cd16975 78 YIAKNLVEKHGGSLIIENSQKGGAEVTV 105
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
494-600 |
6.02e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 85.17 E-value: 6.02e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 494 ITQVLDNIISNAMKYSPEGGHITFTVDLDEEKglVLFSVKDEGIGIPKKDMDKIFERFYRvdkarTRKLG-GTGLGLAIA 572
Cdd:cd16943 4 LNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQ--VLIEVEDTGSGIDPEILGRIFDPFFT-----TKPVGeGTGLGLSLS 76
|
90 100
....*....|....*....|....*...
gi 518573285 573 KEMVQAHGGDIWADSIEGKGTTVTFTLP 600
Cdd:cd16943 77 YRIIQKHGGTIRVASVPGGGTRFTIILP 104
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
494-600 |
6.38e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 85.14 E-value: 6.38e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 494 ITQVLDNIISNA----MKYSPEGGHITFTVDLDEeKGLVLFSVKDEGIGIPKKDMDKIFERFYrvdkarTRKLGGTGLGL 569
Cdd:cd16920 1 IQQVLINLVRNGieamSEGGCERRELTIRTSPAD-DRAVTISVKDTGPGIAEEVAGQLFDPFY------TTKSEGLGMGL 73
|
90 100 110
....*....|....*....|....*....|.
gi 518573285 570 AIAKEMVQAHGGDIWADSIEGKGTTVTFTLP 600
Cdd:cd16920 74 SICRSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
497-600 |
2.43e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 83.25 E-value: 2.43e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 497 VLDNIISNAMKYSPEGGHITFTVDLDEekgLVLfSVKDEGIGIPKKDMDKIFERFYRVDKARTRKLGGTGLGLAIAKEMV 576
Cdd:cd16939 4 ALDNLLRNALRYAHRTVRIALLVSGGR---LTL-IVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVA 79
|
90 100
....*....|....*....|....
gi 518573285 577 QAHGGDIWADSIEGKGTTVTFTLP 600
Cdd:cd16939 80 LWHGGHVECDDSELGGACFRLTWP 103
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
370-600 |
5.74e-19 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 91.51 E-value: 5.74e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 370 EQEKIDAERREFVANVSHELRTPLTTMRSYLEALAegaigDKELAPR---FLSVTQNETERMIRLVNDLLQLSKFD--SK 444
Cdd:PRK11466 436 EAEKASQAKSAFLAAMSHEIRTPLYGILGTAQLLA-----DNPALNAqrdDLRAITDSGESLLTILNDILDYSAIEagGK 510
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 445 DYQFNREWTNFIRFISLVIDRFEMTKEQHV-----DFIRNLPQreiYVEIDQDKITQVLDNIISNAMKYSpEGGHITFTV 519
Cdd:PRK11466 511 NVSVSDEPFEPRPLLESTLQLMSGRVKGRPirlatDIADDLPT---ALMGDPRRIRQVITNLLSNALRFT-DEGSIVLRS 586
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 520 DLDEEKGLVlfSVKDEGIGIPKKDMDKIFERFYRVDKARtrklGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTVTFTL 599
Cdd:PRK11466 587 RTDGEQWLV--EVEDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRL 660
|
.
gi 518573285 600 P 600
Cdd:PRK11466 661 P 661
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
377-580 |
2.87e-18 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 87.78 E-value: 2.87e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 377 ERReFVANVSHELRTPLTTMRSYLEaLAEGAIGDKELAPRFLSVTQNETERMIRLVNDLLQLSKFDSKDyqfNREWTNFI 456
Cdd:PRK10337 237 ERR-FTSDAAHELRSPLAALKVQTE-VAQLSDDDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDSLD---NLQDVAEI 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 457 RFISL----VIDRFEMTKEQHVDFIRNLPQREIYVEIDQDKITQVLDNIISNAMKYSPEGGHITFTVDLDEekglvlFSV 532
Cdd:PRK10337 312 PLEDLlqsaVMDIYHTAQQAGIDVRLTLNAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNARN------FTV 385
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 518573285 533 KDEGIGIPKKDMDKIFERFYR---VDKArtrklgGTGLGLAIAKEMVQAHG 580
Cdd:PRK10337 386 RDNGPGVTPEALARIGERFYRppgQEAT------GSGLGLSIVRRIAKLHG 430
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
376-606 |
4.14e-18 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 88.58 E-value: 4.14e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 376 AERRE----FVANVSHELRTPLTTMRSYLEaLAEGAIGDKELAPRFLSVTQNETERMIRLVNDLLQLSKfdSKDYqfNRE 451
Cdd:PRK13837 444 ARRLEavgtLASGIAHNFNNILGAILGYAE-MALNKLARHSRAARYIDEIISAGARARLIIDQILAFGR--KGER--NTK 518
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 452 WTNFIRFISLVIDRFEMTKEQHVDFIRNLPQREIYVEIDQDKITQVLDNIISNAMKYSPEGGHITFTVD---LDEEKGL- 527
Cdd:PRK13837 519 PFDLSELVTEIAPLLRVSLPPGVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISLSrakLRAPKVLs 598
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 528 ---------VLFSVKDEGIGIPKKDMDKIFERFYrvdkarTRKLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTVTFT 598
Cdd:PRK13837 599 hgvlppgryVLLRVSDTGAGIDEAVLPHIFEPFF------TTRAGGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVY 672
|
....*...
gi 518573285 599 LPYNEEQE 606
Cdd:PRK13837 673 LPPSSKVP 680
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
375-440 |
1.81e-17 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 76.87 E-value: 1.81e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518573285 375 DAERREFVANVSHELRTPLTTMRSYLEALAEGAIGDKELApRFLSVTQNETERMIRLVNDLLQLSK 440
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQR-EYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
494-600 |
3.06e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 77.49 E-value: 3.06e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 494 ITQVLDNIISNAMKYspegGHITFTVDLDEEKGLVLFSVKDEGIGIPKKDMDKIFERFYRVDKARTrkLGGTGLGLAIAK 573
Cdd:cd16950 1 LKRVLSNLVDNALRY----GGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQ 74
|
90 100
....*....|....*....|....*..
gi 518573285 574 EMVQAHGGDIWADSIEGKGTTVTFTLP 600
Cdd:cd16950 75 RISDAHGGSLTLANRAGGGLCARIELP 101
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
377-443 |
4.14e-17 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 75.71 E-value: 4.14e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518573285 377 ERREFVANVSHELRTPLTTMRSYLEALAEGaiGDKELAPRFLSVTQNETERMIRLVNDLLQLSKFDS 443
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDE--KLDEEQREYLETILRSAERLLRLINDLLDLSRIEA 65
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
377-443 |
8.78e-17 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 74.91 E-value: 8.78e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518573285 377 ERREFVANVSHELRTPLTTMRSYLEALAEGAIGDKELapRFLSVTQNETERMIRLVNDLLQLSKFDS 443
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQR--EYLETILREAERLLRLINDLLDLSRIEA 65
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
377-603 |
8.85e-17 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 83.04 E-value: 8.85e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 377 ERREFVANVSHELRTPLTTMR----------SYLealAEGAIGDkelaprflsvtqneTERMIRLVNDLLQLSKFDSKDy 446
Cdd:PRK09467 228 DRTLLMAGVSHDLRTPLTRIRlatemmseedGYL---AESINKD--------------IEECNAIIEQFIDYLRTGQEM- 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 447 QFNREWTNFIrfISLVIDRfEMTKEQHVDFirNLPQREIYVEIDQDKITQVLDNIISNAMKYspegGHITFTVDLDEEKG 526
Cdd:PRK09467 290 PMEMADLNAL--LGEVIAA-ESGYEREIET--ALQPGPIEVPMNPIAIKRALANLVVNAARY----GNGWIKVSSGTEGK 360
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 518573285 527 LVLFSVKDEGIGIPKKDMDKIFERFYRVDKARTRKlgGTGLGLAIAKEMVQAHGGDI-WADSIEGkGTTVTFTLPYNE 603
Cdd:PRK09467 361 RAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARGSS--GTGLGLAIVKRIVDQHNGKVeLGNSEEG-GLSARAWLPLTT 435
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
496-600 |
8.87e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 76.46 E-value: 8.87e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 496 QVLDNIISNAMKYSP-EGGHITftVDLDEEKGLVLFSVKDEGIGIPKKDMDKIFERFYrVDKARTRKLG-GTGLGLAIAK 573
Cdd:cd16953 3 QVLRNLIGNAISFSPpDTGRIT--VSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFY-TERPANEAFGqHSGLGLSISR 79
|
90 100 110
....*....|....*....|....*....|.
gi 518573285 574 EMVQAHGGDIWADSIE----GKGTTVTFTLP 600
Cdd:cd16953 80 QIIEAHGGISVAENHNqpgqVIGARFTVQLP 110
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
496-583 |
1.23e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 75.96 E-value: 1.23e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 496 QVLDNIISNAMKYSPEGGHITFTVDLDEEKglVLFSVKDEGIGIPKKDMDKIFERFYRVDKARTRKlGGTGLGLAIAKEM 575
Cdd:cd16945 7 QAINNLLDNAIDFSPEGGLIALQLEADTEG--IELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQ-KSTGLGLAFVQEV 83
|
....*...
gi 518573285 576 VQAHGGDI 583
Cdd:cd16945 84 AQLHGGRI 91
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
63-590 |
7.39e-15 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 77.80 E-value: 7.39e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 63 DSSKSKAELKEDAQKILNDFNNKDESNEI----SEVSYIDESREV----------IASVNNGSQEIAGKKIT---DQIIS 125
Cdd:COG4192 176 DSVETTESLRNLQNELQLLLRLLAIENQIvsllREVAAARDQADVdnlfdrlqylKDELDRNLQALKNYPSTitlRQLID 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 126 RIFAVGKDYEKKFYDPESNKRVRISATAVKNENQETVGVI------YVVSSMESV--FNQ-----MRTINTILATGTLIA 192
Cdd:COG4192 256 ELLAIGSGEGGLPSLRRDELAAQATLEALAEENNSILEQLrtqisgLVGNSREQLvaLNQetaqlVQQSGILLLAIALLS 335
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 193 LGTTALLGIF-IFRTITHPISDMRKQAIELAKGNFSRKVRKYGHDEIGQLAttfnhltreleeaqlmtegerkklssvia 271
Cdd:COG4192 336 LLLAVLINYFyVRRRLVKRLNALSDAMAAIAAGDLDVPIPVDGNDEIGRIA----------------------------- 386
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 272 ymtdgviatnqngaiillnspalELLNVSRETAlempitsllgleethtfedlVENQDSMLLEIEREDQlsvlrvnfsvI 351
Cdd:COG4192 387 -----------------------RLLRVFRDQA--------------------IEKTQELETEIEERKR----------I 413
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 352 QKEhgkidgLIAviydvTEQEKIDAERREFVA----NVSHELRTPLTTMRSYLEALAEGAIGDK-ELAPRFLSVTQNETE 426
Cdd:COG4192 414 EKN------LRQ-----TQDELIQAAKMAVVGqtmtSLAHELNQPLNAMSMYLFSAKKALEQENyAQLPTSLDKIEGLIE 482
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 427 RMIRLVNDLLQLSKFDSKDYQFnrewtnfIRFISLVIDRFEMTKEQH--VDFIRNLPQrEIYVEIDQDKITQVLDNIISN 504
Cdd:COG4192 483 RMDKIIKSLRQFSRKSDTPLQP-------VDLRQVIEQAWELVESRAkpQQITLHIPD-DLMVQGDQVLLEQVLVNLLVN 554
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 505 AMKYSPEGGHItfTVDLDEEKGLVLFSVKDEGIGIPkkDMDKIFERFYrvdkarTRKLGGTGLGLAIAKEMVQAHGGDIW 584
Cdd:COG4192 555 ALDAVATQPQI--SVDLLSNAENLRVAISDNGNGWP--LVDKLFTPFT------TTKEVGLGLGLSICRSIMQQFGGDLY 624
|
....*..
gi 518573285 585 -ADSIEG 590
Cdd:COG4192 625 lASTLER 631
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
276-600 |
5.19e-14 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 73.58 E-value: 5.19e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 276 GVIATNQNGAIILL---------NSPALELLNVSRETALEMPITSLLG------------LEETHTFED----LVENQDS 330
Cdd:PRK11073 10 GQILNSLINSILLLdddlaihyaNPAAQQLLAQSSRKLFGTPLPELLSyfslnielmresLQAGQGFTDnevtLVIDGRS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 331 MLLEieredqLSVLRVNFSVIQKEHGKIDgliaviydvtEQEKIDAER---------REFVANVSHELRTPLTTMRSYLE 401
Cdd:PRK11073 90 HILS------LTAQRLPEGMILLEMAPMD----------NQRRLSQEQlqhaqqvaaRDLVRGLAHEIKNPLGGLRGAAQ 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 402 ALAEgAIGDKELApRFLSVTQNETERMIRLVNDLLQLSKFDSKdyqfnrEWTNFIRFISLVIDRFEMTKEQHVDFIRN-- 479
Cdd:PRK11073 154 LLSK-ALPDPALT-EYTKVIIEQADRLRNLVDRLLGPQRPGTH------VTESIHKVAERVVQLVSLELPDNVRLIRDyd 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 480 --LPQreiyVEIDQDKITQVLDNIISNAMK-YSPEGGHIT------FTVDLDEEKGLVL--FSVKDEGIGIPKKDMDKIF 548
Cdd:PRK11073 226 psLPE----LAHDPDQIEQVLLNIVRNALQaLGPEGGTITlrtrtaFQLTLHGERYRLAarIDIEDNGPGIPPHLQDTLF 301
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 518573285 549 erfYRVDKARTrklGGTGLGLAIAKEMVQAHGGDIWADSIEGKgTTVTFTLP 600
Cdd:PRK11073 302 ---YPMVSGRE---GGTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLP 346
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
496-600 |
9.99e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 67.79 E-value: 9.99e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 496 QVLDNIISNAMKYSPEGGHITFT-----VDLDEEK---GL-----VLFSVKDEGIGIPKKDMDKIFERFYRvdkarTRKL 562
Cdd:cd16919 3 LAILNLAVNARDAMPEGGRLTIEtsnqrVDADYALnyrDLipgnyVCLEVSDTGSGMPAEVLRRAFEPFFT-----TKEV 77
|
90 100 110
....*....|....*....|....*....|....*....
gi 518573285 563 G-GTGLGLAIAKEMVQAHGGDIWADSIEGKGTTVTFTLP 600
Cdd:cd16919 78 GkGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
471-583 |
4.00e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 66.50 E-value: 4.00e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 471 EQHVDFIRNLPQrEIYVEIDQDKITQVLDNIISNAMKYSPEggHITFTVDLDEEKglVLFSVKDEGIGIPKKDMDKIFER 550
Cdd:cd16954 16 RKGVSISLDISP-ELRFPGERNDLMELLGNLLDNACKWCLE--FVEVTARQTDGG--LHLIVDDDGPGVPESQRSKIFQR 90
|
90 100 110
....*....|....*....|....*....|...
gi 518573285 551 FYRVDKARTrklgGTGLGLAIAKEMVQAHGGDI 583
Cdd:cd16954 91 GQRLDEQRP----GQGLGLAIAKEIVEQYGGEL 119
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
490-600 |
5.66e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 62.55 E-value: 5.66e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 490 DQDKITQVLDNIISNAMKySPEG-----GHITFTVDLDEEKGLVLfSVKDEGIGIPKKDMDKIFERFYrvdkarTRKLGG 564
Cdd:cd16944 1 DTTQISQVLTNILKNAAE-AIEGrpsdvGEVRIRVEADQDGRIVL-IVCDNGKGFPREMRHRATEPYV------TTRPKG 72
|
90 100 110
....*....|....*....|....*....|....*.
gi 518573285 565 TGLGLAIAKEMVQAHGGDIWADSIEGKGTTVTFTLP 600
Cdd:cd16944 73 TGLGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
494-599 |
9.54e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 61.70 E-value: 9.54e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 494 ITQVLDNIISNAMKYSPEGGHITFTVDLDEEKGLVLFSVKDEGIGIPKKDMDKIFERFYRvdkarTRKLG-GTGLGLAIA 572
Cdd:cd16976 1 IQQVLMNLLQNALDAMGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFT-----TKPVGkGTGLGLSIS 75
|
90 100
....*....|....*....|....*..
gi 518573285 573 KEMVQAHGGDIWADSIEGKGTTVTFTL 599
Cdd:cd16976 76 YGIVEEHGGRLSVANEEGAGARFTFDL 102
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
494-600 |
2.19e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 60.88 E-value: 2.19e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 494 ITQVLDNIISNAMK-YSPEGGHIT--------FTVDLDEEKGLVLFSVKDEGIGIPKKDMDKIFERFYrvdkarTRKLGG 564
Cdd:cd16918 1 LIQVFLNLVRNAAQaLAGSGGEIIlrtrtqrqVTLGHPRHRLALRVSVIDNGPGIPPDLQDTIFYPMV------SGRENG 74
|
90 100 110
....*....|....*....|....*....|....*.
gi 518573285 565 TGLGLAIAKEMVQAHGGDIWADSIEGKgTTVTFTLP 600
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
208-252 |
7.86e-11 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 57.07 E-value: 7.86e-11
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 518573285 208 THPISDMRKQAIELAKGNFSRKVRKYGHDEIGQLATTFNHLTREL 252
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| HAMP |
pfam00672 |
HAMP domain; |
202-254 |
2.21e-10 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 56.09 E-value: 2.21e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 518573285 202 FIFRTITHPISDMRKQAIELAKGNFSRKVRKYGHDEIGQLATTFNHLTRELEE 254
Cdd:pfam00672 1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
205-256 |
3.15e-10 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 55.72 E-value: 3.15e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 518573285 205 RTITHPISDMRKQAIELAKGNFSRKVRKYGHDEIGQLATTFNHLTRELEEAQ 256
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETI 52
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
15-254 |
3.79e-10 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 62.73 E-value: 3.79e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 15 TLIYVLLIIVAMQIIGVYFVKQLEQSLINSYDNSLNQRIYSLSYYLEQDSSKSKAELKEDAQKILNDFNNKDESNEISEV 94
Cdd:COG0840 14 LLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLALLLLLL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 95 SYIDESREVIASVNNGSQEIAGKKITDQIISRIFAVGKDYEKKFYDPESNKRVRISATAVKNENQETVGVIYVVSSMESV 174
Cdd:COG0840 94 ALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALLEAAALA 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 175 FNQMRTINTILATGTLIALGTTALLGIFIFRTITHPISDMRKQAIELAKGNFSRKVRKYGHDEIGQLATTFNHLTRELEE 254
Cdd:COG0840 174 LAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENLRE 253
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
497-600 |
5.03e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 56.91 E-value: 5.03e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 497 VLDNIISNAMKYSPE--GGHITFTVDLDEEKGLVLFSVKDEGIGIPKKDMDKIFERFYRvdkarTRKLGGTGLGLAIAKE 574
Cdd:cd16915 4 IVGNLIDNALDALAAtgAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVS-----TKGQGERGIGLALVRQ 78
|
90 100
....*....|....*....|....*.
gi 518573285 575 MVQAHGGDIWADSIEGKGTTVTFTLP 600
Cdd:cd16915 79 SVERLGGSITVESEPGGGTTFSIRIP 104
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
184-502 |
1.68e-09 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 60.28 E-value: 1.68e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 184 ILATGTLIALGTTALLGIFIFRTITHPISDMRKQAIELAKGNFSRKVRKYGHDEIGQLATTFNHLTRELEEAQLMTEGER 263
Cdd:COG3850 119 LALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFNRMADELQELYAELEEEE 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 264 KKLssVIAYMTDGVIATNQNGAIILLNSPALELLNVSRETALEMPITSLLGLEETHTFEDLVENQDSMLLEIEREDQLSV 343
Cdd:COG3850 199 ELE--AELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELLALNILAGLLELLLALLLLLLAS 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 344 LRVNFSVIQKEHGKIDGLIAVIYDVTEQEKIDAERREFVANVSHELRTPLTTMRSYLEALAEGAIGDKELAPRFLSVTQN 423
Cdd:COG3850 277 ALLLLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQAIANASLLLIALASVVAALLELASILALQAALEAA 356
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 518573285 424 ETERMIRLVNDLLQLSKFDSKDYQFNREWTNFIRFISLVIDRFEMTKEQHVDFIRNLPQREIYVEIDQDKITQVLDNII 502
Cdd:COG3850 357 AAGAALAAAAAAAGLARALAQAGADAAEALGLLAEASEGAAGQGAGLVDVEGGVAGEGGLVVLIVSIIAGGEAIARGEA 435
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
502-600 |
2.55e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 54.48 E-value: 2.55e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 502 ISNAMKYSPeGGHITFTVDLDEEkGLVLfSVKDEGIGIPKKDmdkiferfyrvdkartrKLGGTGLGLAIAKEMVQAHGG 581
Cdd:cd16917 9 LTNALKHAG-ASRVRVTLSYTAD-ELTL-TVVDDGVGFDGPA-----------------PPGGGGFGLLGMRERAELLGG 68
|
90
....*....|....*....
gi 518573285 582 DIWADSIEGKGTTVTFTLP 600
Cdd:cd16917 69 TLTIGSRPGGGTRVTARLP 87
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
488-608 |
2.87e-09 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 59.68 E-value: 2.87e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 488 EIDQDKITQVLDNIISNAMKYSPEGGHITF---TVDLDEEKGL----------VLFSVKDEGIGIPKKDMDKIFERFYRv 554
Cdd:PRK13557 272 RIDPTQAEVALLNVLINARDAMPEGGRVTIrtrNVEIEDEDLAmyhglppgryVSIAVTDTGSGMPPEILARVMDPFFT- 350
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 518573285 555 dkarTRKLG-GTGLGLAIAKEMVQAHGGDIWADSIEGKGTTVTFTLPYNEEQEDD 608
Cdd:PRK13557 351 ----TKEEGkGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFPASDQAENP 401
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
494-607 |
3.95e-09 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 59.54 E-value: 3.95e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 494 ITqVLDNIISNAMKY--SPEGGHITftVDLDEEKGLVLFSVKDEGIGIPKKDMDKIFERFYrvdkarTRKLGGTGLGLAI 571
Cdd:PRK11086 435 IT-ILGNLIENALEAvgGEEGGEIS--VSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGY------STKGSNRGVGLYL 505
|
90 100 110
....*....|....*....|....*....|....*.
gi 518573285 572 AKEMVQAHGGDIWADSIEGKGTTVTFTLPYNEEQED 607
Cdd:PRK11086 506 VKQSVENLGGSIAVESEPGVGTQFFVQIPWDGERSN 541
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
490-583 |
6.96e-09 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 58.49 E-value: 6.96e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 490 DQDKITQVLDNIISNAMKYSPEGGHITFTVDldeEKGLVLFsVKDEGIGIPKKDMDKIFERFYRVDKARTrklgGTGLGL 569
Cdd:PRK10815 375 EKNDFMEVMGNVLDNACKYCLEFVEISARQT---DEHLHIV-VEDDGPGIPESKRELIFDRGQRADTLRP----GQGLGL 446
|
90
....*....|....
gi 518573285 570 AIAKEMVQAHGGDI 583
Cdd:PRK10815 447 SVAREITEQYEGKI 460
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
498-604 |
1.54e-08 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 57.34 E-value: 1.54e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 498 LDNIISNAMKYSPEGGHITFTVDLDEEKglVLFSVKDEGIGIPKKDMDKIFERFyrvdkarTRKLGGTGLGLAIAKEMVQ 577
Cdd:COG2972 345 VENAIEHGIEPKEGGGTIRISIRKEGDR--LVITVEDNGVGMPEEKLEKLLEEL-------SSKGEGRGIGLRNVRERLK 415
|
90 100 110
....*....|....*....|....*....|
gi 518573285 578 AHGGD---IWADSIEGKGTTVTFTLPYNEE 604
Cdd:COG2972 416 LYYGEeygLEIESEPGEGTTVTIRIPLEEE 445
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
256-380 |
1.62e-08 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 57.09 E-value: 1.62e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 256 QLMTEGERKKLSSVIAYMTDGVIATNQNGAIILLNSPALELLNVSRETALEMPITSLLglEETHTFEDLVENQDSMLLEI 335
Cdd:COG3829 3 ELELKELEEELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVTELI--PNSPLLEVLKTGKPVTGVIQ 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 518573285 336 EREDQLSVLRVNFSVIqKEHGKIDGLIAVIYDVTEQEKIDAERRE 380
Cdd:COG3829 81 KTGGKGKTVIVTAIPI-FEDGEVIGAVETFRDITELKRLERKLRE 124
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
502-604 |
1.80e-08 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 55.78 E-value: 1.80e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 502 ISNAMKYSPeGGHITftVDLDEEKGLVLFSVKDEGIGIPkkdmdkiferfyrvdkarTRKLGGTGLGLAIAKEMVQAHGG 581
Cdd:COG4585 171 LTNALKHAG-ATRVT--VTLEVDDGELTLTVRDDGVGFD------------------PEAAPGGGLGLRGMRERAEALGG 229
|
90 100
....*....|....*....|...
gi 518573285 582 DIWADSIEGKGTTVTFTLPYNEE 604
Cdd:COG4585 230 TLTIGSAPGGGTRVRATLPLAAA 252
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
40-266 |
2.54e-08 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 56.56 E-value: 2.54e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 40 SLINSYDNSLNQRIYSLSYYLEQDSSKSKAELKEDAQKILNDFNNKDESNEISEVSYIDESREVIASVNNGSQEIAGKKI 119
Cdd:COG2972 8 LSIVLLLLILLLLVLLILLLSLLLIILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLILLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 120 TDQIISRIFAVGKDYEKKFYDPESNKRVRISATAVKNENQETVGV------IYVVSSMESVFNQMRTINTILATGTLIAL 193
Cdd:COG2972 88 LLLLLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLsllgwtLVSLIPKSELFRGLFSLRRLILLIILLLL 167
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 518573285 194 GTTALLGIFIFRTITHPISDMRKQAIELAKGNFSRkVRKYGHDEIGQLATTFNHLTRELEEaqLMTEGERKKL 266
Cdd:COG2972 168 LLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLVR-LEVSGNDEIGILARSFNEMVERIKE--LIEEVYELEL 237
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
14-385 |
2.59e-08 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 57.05 E-value: 2.59e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 14 LTLIYVLLIIVAMQIIGVYFVKQLEQSLINSYDNSLNQRIYSLSYYLEQDSSKSKAELKEDAQKILNDFNNKDESNEISE 93
Cdd:COG2770 46 LLALLLLLLLLLLLLLAALVLLALLLAAALLLLLLLLSLVALAALLLALLLLLLLALLLLLAALLLLLLLAALALLLLLL 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 94 VSYIDESREVIASVNNGSQEIAGKKITDQIISRIFAVGKDYEKKFYDPESNKRVRISATAVKNENQETVGVIYVVSSMES 173
Cdd:COG2770 126 LLLAALLALLLALALLALLLGLAAARLLLAALLALAAALALALGAGELLLLADLAAAIAALLAALLLLLLGGLLLVVLLE 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 174 VFNQMRTINTILAtgtLIALGTTALLGIFIFRTITHPISDMRKQAIELAKGNFSRKVRKYGHDEIGQLATTFNHLTRELE 253
Cdd:COG2770 206 AALAALLLLLLLA---LLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNRMADSLR 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 254 EAQLMTEGERKKLSSVIAYMTDGVIATNQNGAIILLNSPALELLNVSRETALEMPITSLLGLEETHTFEDLVENQDSMLL 333
Cdd:COG2770 283 ESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLL 362
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 518573285 334 EIEREDQLSVLRVNFSVIQKEHGKIDGLIAVIYDVTEQEKIDAERREFVANV 385
Cdd:COG2770 363 LALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVL 414
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
254-380 |
1.78e-06 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 49.64 E-value: 1.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 254 EAQLMTEGERKKLSSVIAYMTDGVIATNQNGAIILLNSPALELLNVSRETALEMPITSLLGLEETHTF----EDLVENQD 329
Cdd:COG2202 1 TAEEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLPPEDDDEFlellRAALAGGG 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 518573285 330 SMLLEIERED---QLSVLRVNFSVIQKEHGKIDGLIAVIYDVTEQEKIDAERRE 380
Cdd:COG2202 81 VWRGELRNRRkdgSLFWVELSISPVRDEDGEITGFVGIARDITERKRAEEALRE 134
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
273-368 |
6.97e-06 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 44.93 E-value: 6.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 273 MTDGVIATNQNGAIILLNSPALELLNVSRETALEMPITSLLGLEETHTFEDLVEN----QDSMLLEIE---REDQLSVLR 345
Cdd:cd00130 1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENllsgGEPVTLEVRlrrKDGSVIWVL 80
|
90 100
....*....|....*....|...
gi 518573285 346 VNFSVIQKEHGKIDGLIAVIYDV 368
Cdd:cd00130 81 VSLTPIRDEGGEVIGLLGVVRDI 103
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
502-606 |
8.56e-06 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 48.75 E-value: 8.56e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 502 ISNAMKY---SPEGGHITftVDLDEEKGLVLFSVKDEGIGIPKkdmdkiferfyRVDKARTRklggtGLGLAIAKEMVQA 578
Cdd:COG3920 408 VTNALKHaflSGEGGRIR--VSWRREDGRLRLTVSDNGVGLPE-----------DVDPPARK-----GLGLRLIRALVRQ 469
|
90 100
....*....|....*....|....*...
gi 518573285 579 HGGDIwaDSIEGKGTTVTFTLPYNEEQE 606
Cdd:COG3920 470 LGGTL--ELDRPEGTRVRITFPLAELAA 495
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
490-600 |
1.38e-05 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 44.90 E-value: 1.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 490 DQDKITQVLDNIISNAMKYS---PEGGHITFTVDLDEEKglVLFSVKDEGIGIPKKDMDkiferfyrvDKARTRKLGgtG 566
Cdd:COG2172 31 DADDLVLAVSEAVTNAVRHAyggDPDGPVEVELELDPDG--LEIEVRDEGPGFDPEDLP---------DPYSTLAEG--G 97
|
90 100 110
....*....|....*....|....*....|....*...
gi 518573285 567 LGLAIAKEMvqahggdiwADSIE----GKGTTVTFTLP 600
Cdd:COG2172 98 RGLFLIRRL---------MDEVEyesdPGGTTVRLVKR 126
|
|
| HATPase_ETR2_ERS2-EIN4-like |
cd16938 |
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related ... |
490-599 |
1.46e-05 |
|
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related domains; This family includes the histidine kinase-like ATPase domains (HATPase) of three out of the five receptors that recognize the plant hormone ethylene in Arabidopsis thaliana. These three proteins have been classified as belonging to subfamily 2: ETR2, ERS2, and EIN4. They lack most of the motifs characteristic of histidine kinases, and EIN4 is the only one in this group containing the conserved histidine that is phosphorylated in two-component and phosphorelay systems. This family also includes the HATPase domains of Escherichia coli RcsD phosphotransferase which is a component of the Rcs-signaling system, a complex multistep phosphorelay involving five proteins, and is involved in many transcriptional networks such as cell division, biofilm formation, and virulence, among others. Also included is Schizosaccharomyces pombe Mak3 (Phk1) which participates in a multi-step two-component related system which regulates H2O2-induced activation of the Sty1 stress-activated protein kinase pathway. Most proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a GAF sensor domain; most are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340415 [Multi-domain] Cd Length: 133 Bit Score: 44.76 E-value: 1.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 490 DQDKITQVLDNIISNAMKYSPEGGHITFTVDLdeEKGLVLFSVKDEGIGIPKKDMDKIFERF-YRV--------DKARTR 560
Cdd:cd16938 8 DERRVFQVLLHMLGNLLKMRNGGGNITFRVFL--EGGSEDRSDRDWGPWRPSMSDESVEIRFeVEIndsgspsiESASMR 85
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 518573285 561 K---------LGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTVTFTL 599
Cdd:cd16938 86 NslnrrynlsELGEHLSFSICKQLVQLMGGNIWIVPGSGLGTTMSLLL 133
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
370-611 |
2.89e-05 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 47.23 E-value: 2.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 370 EQEKIDAERREFVANVSHELRTPLTTMRSYLEALAEGAIGDKELAPrfLSVTQNETERMIRLVNDLLQLSKFDSKDYQFN 449
Cdd:PRK10618 442 EYEKNQQARKAFLQNIGDELKQPLQSLAQLAAQLRQTSDEEQQQPE--LDQLAEQSDVLVRLVDNIQLLNMLETQDWKPE 519
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 450 REWTNFIRFI-SLVIDRFEMTKEQHVD-FIRN-LPQREIYVEiDQDkitqVLDNIISNAMKYS---PEGGHITFTVDLDE 523
Cdd:PRK10618 520 QELFSLQDLIdEVLPEVLPAIKRKGLQlLIHNhLKAEQLRIG-DRD----ALRKILLLLLNYAittTAYGKITLEVDQDE 594
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 524 E-KGLVLFSVKDEGIGIPKKDMDKIfeRFYRVDKARTRKLG-GTGLGLAIAKEMVQAHGGDIWADSIEGKGTTVTFTLPY 601
Cdd:PRK10618 595 SsPDRLTIRILDTGAGVSIKELDNL--HFPFLNQTQGDRYGkASGLTFFLCNQLCRKLGGHLTIKSREGLGTRYSIHLKM 672
|
250
....*....|
gi 518573285 602 NEEQEDDWDE 611
Cdd:PRK10618 673 LAADPEVEEE 682
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
489-607 |
3.58e-05 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 46.75 E-value: 3.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 489 IDQDKITQVLDNIISNAMKYS---PEGGHITfTVDLDEEKGLVLFSVKDEGIGIPKKDMDKIFERFYrvdKARTRKLGGT 565
Cdd:PRK15053 428 LDSTEFAAIVGNLLDNAFEASlrsDEGNKIV-ELFLSDEGDDVVIEVADQGCGVPESLRDKIFEQGV---STRADEPGEH 503
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 518573285 566 GLGLAIAKEMVQAHGGDIWADSIEGKGTTVTFTLPYNEEQED 607
Cdd:PRK15053 504 GIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFIPKVKPNDS 545
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
265-328 |
7.60e-05 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 40.85 E-value: 7.60e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 518573285 265 KLSSVIAYMTDGVIATNQNGAIILLNSPALELLNVSRETALEMPITSLLGLEETHTFEDLVENQ 328
Cdd:smart00091 2 RLRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHPEDRERVQEALQRL 65
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
250-378 |
2.95e-04 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 43.09 E-value: 2.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 250 RELEEAQLMTEgerKKLSSVIAYMTDGVIATNQNGAIILLNSPALELLNVSRETALEMPITSLLGLEETHTFEDLVEN-- 327
Cdd:COG2202 126 KRAEEALRESE---ERLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKSLLDLLHPEDRERLLELLRRll 202
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 518573285 328 -QDSMLLEIE---REDQLSVLRVNFSVIQKEHG-KIDGLIAVIYDVTEQEKIDAER 378
Cdd:COG2202 203 eGGRESYELElrlKDGDGRWVWVEASAVPLRDGgEVIGVLGIVRDITERKRAEEAL 258
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
496-600 |
5.11e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 39.72 E-value: 5.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 496 QVL-DNIISNAMKYSPEGGHITftVDLDEEKGLVLFSVKDEGIGIPKKDMDKIFERFYRVDKartrklgGTGLGLA-IAK 573
Cdd:cd16957 7 QVLvENAIRHAFPKRKENNEVR--VVVKKDQHKVHVSVSDNGQGIPEERLDLLGKTTVTSEK-------GTGTALEnLNR 77
|
90 100
....*....|....*....|....*....
gi 518573285 574 EMVQAHG--GDIWADSIEGKGTTVTFTLP 600
Cdd:cd16957 78 RLIGLFGseACLHIESEVHGGTEVWFVIP 106
|
|
| PRK13560 |
PRK13560 |
hypothetical protein; Provisional |
354-597 |
8.85e-04 |
|
hypothetical protein; Provisional
Pssm-ID: 106506 [Multi-domain] Cd Length: 807 Bit Score: 42.35 E-value: 8.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 354 EHGKIDGLIAVIYDVTE----QEKIDA---ERREFVANVSHELRTPLTTMRSYLEALAEgAIGDKELAPRFlsvtqNETE 426
Cdd:PRK13560 574 EEGQISHFEGIVIDISErkhaEEKIKAaltEKEVLLKEIHHRVKNNLQIISSLLDLQAE-KLHDEEAKCAF-----AESQ 647
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 427 RMIR---LVNDLLqlskFDSKDYQFnrewTNFIRFI-SLVidrfemtkeQHVDFIRNLPQREIYVEIDQDKITQVLDNII 502
Cdd:PRK13560 648 DRICamaLAHEKL----YQSEDLAD----IDFLDYIeSLT---------AHLKNSFAIDFGRIDCKIDADDGCLDIDKAI 710
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 503 ----------SNAMKYS-PEGGHITFTVDLDEEK-GLVLFSVKDEGIGIPkKDMDkiferfYRvdKARTrklggtgLGLA 570
Cdd:PRK13560 711 pcgliisellSNALKHAfPDGAAGNIKVEIREQGdGMVNLCVADDGIGLP-AGFD------FR--AAET-------LGLQ 774
|
250 260
....*....|....*....|....*..
gi 518573285 571 IAKEMVQAHGGDIWADSIEGKGTTVTF 597
Cdd:PRK13560 775 LVCALVKQLDGEIALDSRGGARFNIRF 801
|
|
| HATPase_RsbT-like |
cd16934 |
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine ... |
488-596 |
9.23e-04 |
|
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.
Pssm-ID: 340411 [Multi-domain] Cd Length: 117 Bit Score: 39.28 E-value: 9.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 488 EIDQDKITQVLDNIISNAMKYSpEGGHITFTVDLDEEKGLVLFSVKDEGIGIPkkDMDKIFErfyrvDKARTRklGGTGL 567
Cdd:cd16934 20 EVRQAEIATAVTELARNLLKHA-GGGQVLLEVVAEGGRVALEILAVDQGPGIA--DVDEALR-----DGFSTG--GGLGL 89
|
90 100
....*....|....*....|....*....
gi 518573285 568 GLAIAKEMvqAHGGDIwaDSIEGKGTTVT 596
Cdd:cd16934 90 GLGGVRRL--ADEFDL--HSAPGRGTVVV 114
|
|
| HATPase_PDK-like |
cd16929 |
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ... |
515-600 |
1.84e-03 |
|
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.
Pssm-ID: 340406 [Multi-domain] Cd Length: 169 Bit Score: 39.63 E-value: 1.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 515 ITFTVDLDEEKglVLFSVKDEGIGIPKKDMDKIFERFY-------------RVDKARTRKLGGTGLGLAIAKEMVQAHGG 581
Cdd:cd16929 73 IKVTVAKGDED--LTIKISDRGGGIPREDLARLFSYMYstapqpslddfsdLISGTQPSPLAGFGYGLPMSRLYAEYFGG 150
|
90
....*....|....*....
gi 518573285 582 DIWADSIEGKGTTVTFTLP 600
Cdd:cd16929 151 DLDLQSMEGYGTDVYIYLK 169
|
|
| PRK11388 |
PRK11388 |
DNA-binding transcriptional regulator DhaR; Provisional |
257-315 |
3.56e-03 |
|
DNA-binding transcriptional regulator DhaR; Provisional
Pssm-ID: 183114 [Multi-domain] Cd Length: 638 Bit Score: 40.43 E-value: 3.56e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 518573285 257 LMTEGER--KKLSSVIAYMTDGVIATNQNGAIILLNSPALELLNVSRETALEMPITSLLGL 315
Cdd:PRK11388 194 LLAESNRhlNQLNALLESMDDGVIAWDEQGNLQFLNAQAARLLRLDATASQGRAITELLTL 254
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
487-600 |
5.43e-03 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 38.33 E-value: 5.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 487 VEIDQDKITQVLD---NIISNAMKYS------------PEGGHITFTVDldEEKGLVLFSVKDEGIGI-PKKDMDKIFER 550
Cdd:cd16916 29 TELDKSVLEKLADpltHLLRNAVDHGieapeerlaagkPPEGTITLRAE--HQGNQVVIEVSDDGRGIdREKIREKAIER 106
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518573285 551 FYRVDKARTR----------------------KLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTVTFTLP 600
Cdd:cd16916 107 GLITADEAATlsddevlnlifapgfstaeqvtDVSGRGVGMDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| UhpB |
COG3851 |
Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction ... |
502-600 |
6.80e-03 |
|
Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction mechanisms];
Pssm-ID: 443060 [Multi-domain] Cd Length: 493 Bit Score: 39.22 E-value: 6.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 502 ISNAMKYSpEGGHITftVDLDEEKGLVLFSVKDEGIGIPkkdmdkiferfyrvdkARTRKlggTGLGLAIAKEMVQAHGG 581
Cdd:COG3851 409 LTNILKHA-EASQIR--ISLSQDKRLLSLEIRDDGIGLP----------------PELRA---KGFGLRGMRERVRALGG 466
|
90
....*....|....*....
gi 518573285 582 DiWADSIEGKGTTVTFTLP 600
Cdd:COG3851 467 D-FRLSSAPKGTRLSVLLP 484
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
510-600 |
7.58e-03 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 39.39 E-value: 7.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518573285 510 PEGGHITFTVDLdeEKGLVLFSVKDEGIGIpkkDMDKIFErfyrvdKARTRKL---------------------G----- 563
Cdd:COG0643 306 PETGTITLSAYH--EGGRVVIEVSDDGRGL---DLEKIRA------KAIEKGLitaeeaaalsdeellelifapGfstae 374
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 518573285 564 ------GTGLGLAIAKEMVQAHGGDIWADSIEGKGTTVTFTLP 600
Cdd:COG0643 375 evtdlsGRGVGMDVVKTNIEALGGTIEIESEPGKGTTFTLRLP 417
|
|
| |
