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phosphoribosylformylglycinamidine synthase [Bifidobacterium breve]
Protein Classification
phosphoribosylformylglycinamidine synthase ( domain architecture ID 11493214 )
phosphoribosylformylglycinamidine synthase catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate
List of domain hits
Name
Accession
Description
Interval
E-value
FGAM-synthase
TIGR01857 phosphoribosylformylglycinamidine synthase, clade II; This model represents a single-molecule ...
3-1242
0e+00
phosphoribosylformylglycinamidine synthase, clade II; This model represents a single-molecule form of phosphoribosylformylglycinamidine synthase, also called FGAM synthase, an enzyme of purine de novo biosynthesis. This model represents a second clade of these enzymes found in Clostridia, Bifidobacteria and Streptococcus species. This enzyme performs the fourth step in IMP biosynthesis (the precursor of all purines) from PRPP. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 130916 [Multi-domain]
Cd Length: 1239
Bit Score: 2246.63
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 3 F RV Y VEKK P GFDVE A Q Q L AG ELR TI LGL TG LK A LRIVN R YDV EGISQ ELF DQ TV P T V FSEP QV D N V AYD L PDF A G - AK V F 81
Cdd:TIGR01857 1 K RV F VEKK A GFDVE S Q S L VK ELR HN LGL SS LK D LRIVN V YDV FDLAE ELF AP TV K T I FSEP VT D H V LDE L SVQ A D l AK F F 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 82 A T EFLPGQFDQRADSA A ECI Q L I S QG E RP TV RS AKLY A L E G E L T D ADVDT IK H Y V INPV EA RE AS L E T KET L KTQVPV P G 161
Cdd:TIGR01857 81 A V EFLPGQFDQRADSA Q ECI L L L S ES E DV TV NT AKLY I L N G D L D D EELNK IK N Y Y INPV DS RE KD L T T GKA L EEFSES P K 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 162 K VET IA GF NEM DAE AGQ KF ID E R GLAM D L A DL E F C Q K YF SEE GR E PT I TEIKV I DTYWSDHCRHTTF G TEL DE V DID D -- 239
Cdd:TIGR01857 161 E VET LT GF ESY DAE DLA KF KA E Q GLAM S L E DL K F I Q D YF KSI GR N PT E TEIKV L DTYWSDHCRHTTF E TEL KH V TFS D sk 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 240 -- ATV K A A F E R YL E MR H ELGR DA KPV C LMDM G TI G AK W L K KNG I L TG L DE SEEINAC T V KVK VDV N G ENQD WL FL FKNET 317
Cdd:TIGR01857 241 fq KQL K K A Y E D YL A MR E ELGR SE KPV T LMDM A TI F AK Y L R KNG K L DD L EV SEEINAC S V EIE VDV D G VKEP WL LM FKNET 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 318 HNHPTEIEPFGGAATCIGG C IRDPLSGRSYVYQAMRVTGA A DPTVP V SETL E GKLPQRK LV TTAA A GYSSYGNQIGLATG 397
Cdd:TIGR01857 321 HNHPTEIEPFGGAATCIGG A IRDPLSGRSYVYQAMRVTGA G DPTVP I SETL K GKLPQRK IT TTAA H GYSSYGNQIGLATG 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 398 QV D EIYHPGYVAKRMEVGAVVAATP ADH V R RE T P A PGD K IILLGG R TGRDGIGGATG A SK A H N VESLEL D GAEVQKGNAP 477
Cdd:TIGR01857 401 QV S EIYHPGYVAKRMEVGAVVAATP KEN V V RE K P E PGD V IILLGG K TGRDGIGGATG S SK E H T VESLEL C GAEVQKGNAP 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 478 V ERK L QRLFR R G DAC RLIK R CNDFGAGGVSVA V GELADGL FV DLN T VPKKYEGL D GTELAISESQERMAV D V AA EDVD E F 557
Cdd:TIGR01857 481 E ERK I QRLFR N G NVT RLIK K CNDFGAGGVSVA I GELADGL EI DLN K VPKKYEGL N GTELAISESQERMAV V V SP EDVD A F 560
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 558 L T Y AR EENLEATV I ATVTE D PR M VM T WNG DE IV N LSR E FL AS NG ASKHQTVH V EAQ ---- QGYETPWGEG TL A E RMN K MV 633
Cdd:TIGR01857 561 L A Y CN EENLEATV V ATVTE K PR L VM N WNG KT IV D LSR R FL DT NG VRQVIDAK V VDK dvkl PEERQKTSAE TL E E DWL K VL 640
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 634 T DLNVAS N KGL S ERFDS TI GAGTVLMP F GGK R QLTP NM A M VAKLPV F - GET T TASA M AWGFNPYI MSKNQFT GA YLS V V E 712
Cdd:TIGR01857 641 S DLNVAS Q KGL Q ERFDS SV GAGTVLMP L GGK Y QLTP TE A S VAKLPV L g GET H TASA I AWGFNPYI AEWSPYH GA AYA V I E 720
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 713 SLAKLVAAG FEHE KA Y LSFQEYFEKL RDEP ERWGKP T AA V LGA LM AQ V DLG AG AIGGKDSMSG S FE D L D VPPTLISFAV A 792
Cdd:TIGR01857 721 SLAKLVAAG ADYK KA R LSFQEYFEKL DKDA ERWGKP F AA L LGA IK AQ I DLG LP AIGGKDSMSG T FE E L T VPPTLISFAV T 800
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 793 VG N MK R AT SPEFK G A DHR I VR I APRY L A DG l T P D K D A L L E V F SV IEEL TDF H DALAV S TPG YG AT AE A L F KMT L GNRIG V 872
Cdd:TIGR01857 801 TA N SR R VI SPEFK A A GEN I YL I PGQA L E DG - T I D F D L L K E N F AQ IEEL IAD H KVVSA S AVK YG GV AE S L A KMT F GNRIG A 879
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 873 T LN DSI a VD DLFT PA YGSFI V E LADN aklpav SNLVEIGE IG T TT SEYAF K AA GE T LDL NAVQE AWE SGI E S VFP Y rs K G 952
Cdd:TIGR01857 880 E LN NPE - LE DLFT AQ YGSFI F E SPEE ------ LSIANVEK IG Q TT ADFVL K VN GE K LDL EELES AWE GKL E E VFP S -- K F 950
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 953 EDK GK TVE TIDFHAP KK TAYTGSS V A KP H VVIPVFPG N N C EYDSA A AFE RA GA D V TTL I VN NL TPA A VA ES TQAL V E EI N 1032
Cdd:TIGR01857 951 EDK KE TVE VPAVASE KK VIKAKEK V E KP R VVIPVFPG T N S EYDSA K AFE KE GA E V NLV I FR NL NEE A LV ES VETM V D EI D 1030
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 1033 KSQI V M I PGGFS G GDEPDGSAKFI T A FF R A P A V TE A VRDL L k N RDGL M LGICNGFQALVK L GL V PYG D I VPMTDAC PTLT 1112
Cdd:TIGR01857 1031 KSQI L M L PGGFS A GDEPDGSAKFI A A IL R N P K V RV A IDSF L - A RDGL I LGICNGFQALVK S GL L PYG N I EAANETS PTLT 1109
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 1113 F N T I G RH Q S RL VRTR V AS DL SPWL AKT SVGDIH TVAI SHGEGRFVASDEVLA Q L KA NGQIATQYVD EA G T P G MD LDV NPN 1192
Cdd:TIGR01857 1110 Y N D I N RH V S KI VRTR I AS TN SPWL SGV SVGDIH AIPV SHGEGRFVASDEVLA E L RE NGQIATQYVD FN G K P S MD SKY NPN 1189
1210 1220 1230 1240 1250
....*....|....*....|....*....|....*....|....*....|
gi 518557708 1193 GS L LAIEGITSPDGR V FGKMGHSER S G N GL YV N V PGNK Y Q PI F EA GV E YF 1242
Cdd:TIGR01857 1190 GS S LAIEGITSPDGR I FGKMGHSER Y G D GL FK N I PGNK D Q HL F AS GV K YF 1239
Name
Accession
Description
Interval
E-value
FGAM-synthase
TIGR01857 phosphoribosylformylglycinamidine synthase, clade II; This model represents a single-molecule ...
3-1242
0e+00
phosphoribosylformylglycinamidine synthase, clade II; This model represents a single-molecule form of phosphoribosylformylglycinamidine synthase, also called FGAM synthase, an enzyme of purine de novo biosynthesis. This model represents a second clade of these enzymes found in Clostridia, Bifidobacteria and Streptococcus species. This enzyme performs the fourth step in IMP biosynthesis (the precursor of all purines) from PRPP. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 130916 [Multi-domain]
Cd Length: 1239
Bit Score: 2246.63
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 3 F RV Y VEKK P GFDVE A Q Q L AG ELR TI LGL TG LK A LRIVN R YDV EGISQ ELF DQ TV P T V FSEP QV D N V AYD L PDF A G - AK V F 81
Cdd:TIGR01857 1 K RV F VEKK A GFDVE S Q S L VK ELR HN LGL SS LK D LRIVN V YDV FDLAE ELF AP TV K T I FSEP VT D H V LDE L SVQ A D l AK F F 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 82 A T EFLPGQFDQRADSA A ECI Q L I S QG E RP TV RS AKLY A L E G E L T D ADVDT IK H Y V INPV EA RE AS L E T KET L KTQVPV P G 161
Cdd:TIGR01857 81 A V EFLPGQFDQRADSA Q ECI L L L S ES E DV TV NT AKLY I L N G D L D D EELNK IK N Y Y INPV DS RE KD L T T GKA L EEFSES P K 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 162 K VET IA GF NEM DAE AGQ KF ID E R GLAM D L A DL E F C Q K YF SEE GR E PT I TEIKV I DTYWSDHCRHTTF G TEL DE V DID D -- 239
Cdd:TIGR01857 161 E VET LT GF ESY DAE DLA KF KA E Q GLAM S L E DL K F I Q D YF KSI GR N PT E TEIKV L DTYWSDHCRHTTF E TEL KH V TFS D sk 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 240 -- ATV K A A F E R YL E MR H ELGR DA KPV C LMDM G TI G AK W L K KNG I L TG L DE SEEINAC T V KVK VDV N G ENQD WL FL FKNET 317
Cdd:TIGR01857 241 fq KQL K K A Y E D YL A MR E ELGR SE KPV T LMDM A TI F AK Y L R KNG K L DD L EV SEEINAC S V EIE VDV D G VKEP WL LM FKNET 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 318 HNHPTEIEPFGGAATCIGG C IRDPLSGRSYVYQAMRVTGA A DPTVP V SETL E GKLPQRK LV TTAA A GYSSYGNQIGLATG 397
Cdd:TIGR01857 321 HNHPTEIEPFGGAATCIGG A IRDPLSGRSYVYQAMRVTGA G DPTVP I SETL K GKLPQRK IT TTAA H GYSSYGNQIGLATG 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 398 QV D EIYHPGYVAKRMEVGAVVAATP ADH V R RE T P A PGD K IILLGG R TGRDGIGGATG A SK A H N VESLEL D GAEVQKGNAP 477
Cdd:TIGR01857 401 QV S EIYHPGYVAKRMEVGAVVAATP KEN V V RE K P E PGD V IILLGG K TGRDGIGGATG S SK E H T VESLEL C GAEVQKGNAP 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 478 V ERK L QRLFR R G DAC RLIK R CNDFGAGGVSVA V GELADGL FV DLN T VPKKYEGL D GTELAISESQERMAV D V AA EDVD E F 557
Cdd:TIGR01857 481 E ERK I QRLFR N G NVT RLIK K CNDFGAGGVSVA I GELADGL EI DLN K VPKKYEGL N GTELAISESQERMAV V V SP EDVD A F 560
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 558 L T Y AR EENLEATV I ATVTE D PR M VM T WNG DE IV N LSR E FL AS NG ASKHQTVH V EAQ ---- QGYETPWGEG TL A E RMN K MV 633
Cdd:TIGR01857 561 L A Y CN EENLEATV V ATVTE K PR L VM N WNG KT IV D LSR R FL DT NG VRQVIDAK V VDK dvkl PEERQKTSAE TL E E DWL K VL 640
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 634 T DLNVAS N KGL S ERFDS TI GAGTVLMP F GGK R QLTP NM A M VAKLPV F - GET T TASA M AWGFNPYI MSKNQFT GA YLS V V E 712
Cdd:TIGR01857 641 S DLNVAS Q KGL Q ERFDS SV GAGTVLMP L GGK Y QLTP TE A S VAKLPV L g GET H TASA I AWGFNPYI AEWSPYH GA AYA V I E 720
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 713 SLAKLVAAG FEHE KA Y LSFQEYFEKL RDEP ERWGKP T AA V LGA LM AQ V DLG AG AIGGKDSMSG S FE D L D VPPTLISFAV A 792
Cdd:TIGR01857 721 SLAKLVAAG ADYK KA R LSFQEYFEKL DKDA ERWGKP F AA L LGA IK AQ I DLG LP AIGGKDSMSG T FE E L T VPPTLISFAV T 800
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 793 VG N MK R AT SPEFK G A DHR I VR I APRY L A DG l T P D K D A L L E V F SV IEEL TDF H DALAV S TPG YG AT AE A L F KMT L GNRIG V 872
Cdd:TIGR01857 801 TA N SR R VI SPEFK A A GEN I YL I PGQA L E DG - T I D F D L L K E N F AQ IEEL IAD H KVVSA S AVK YG GV AE S L A KMT F GNRIG A 879
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 873 T LN DSI a VD DLFT PA YGSFI V E LADN aklpav SNLVEIGE IG T TT SEYAF K AA GE T LDL NAVQE AWE SGI E S VFP Y rs K G 952
Cdd:TIGR01857 880 E LN NPE - LE DLFT AQ YGSFI F E SPEE ------ LSIANVEK IG Q TT ADFVL K VN GE K LDL EELES AWE GKL E E VFP S -- K F 950
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 953 EDK GK TVE TIDFHAP KK TAYTGSS V A KP H VVIPVFPG N N C EYDSA A AFE RA GA D V TTL I VN NL TPA A VA ES TQAL V E EI N 1032
Cdd:TIGR01857 951 EDK KE TVE VPAVASE KK VIKAKEK V E KP R VVIPVFPG T N S EYDSA K AFE KE GA E V NLV I FR NL NEE A LV ES VETM V D EI D 1030
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 1033 KSQI V M I PGGFS G GDEPDGSAKFI T A FF R A P A V TE A VRDL L k N RDGL M LGICNGFQALVK L GL V PYG D I VPMTDAC PTLT 1112
Cdd:TIGR01857 1031 KSQI L M L PGGFS A GDEPDGSAKFI A A IL R N P K V RV A IDSF L - A RDGL I LGICNGFQALVK S GL L PYG N I EAANETS PTLT 1109
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 1113 F N T I G RH Q S RL VRTR V AS DL SPWL AKT SVGDIH TVAI SHGEGRFVASDEVLA Q L KA NGQIATQYVD EA G T P G MD LDV NPN 1192
Cdd:TIGR01857 1110 Y N D I N RH V S KI VRTR I AS TN SPWL SGV SVGDIH AIPV SHGEGRFVASDEVLA E L RE NGQIATQYVD FN G K P S MD SKY NPN 1189
1210 1220 1230 1240 1250
....*....|....*....|....*....|....*....|....*....|
gi 518557708 1193 GS L LAIEGITSPDGR V FGKMGHSER S G N GL YV N V PGNK Y Q PI F EA GV E YF 1242
Cdd:TIGR01857 1190 GS S LAIEGITSPDGR I FGKMGHSER Y G D GL FK N I PGNK D Q HL F AS GV K YF 1239
PurL_repeat1
cd02203 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. ...
211-592
5.11e-133
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100034 [Multi-domain]
Cd Length: 313
Bit Score: 408.78
E-value: 5.11e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 211 E IKVIDTY WS D HCRH TT F GTE L DEV diddatvkaaferylemrhelgrdakpvclmdmgtigakwlkkngiltgldesee 290
Cdd:cd02203 1 E LGMFAQM WS E HCRH KS F KSL L KMI ------------------------------------------------------- 25
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 291 inactvkvkvdvngenqd W LFL FK N ETHNHP TE IEPFGGAAT CI GG C IRD P LS GRSYVYQAMRVTGAA D PTV P VS E t LE G 370
Cdd:cd02203 26 ------------------ W AVV FK V ETHNHP SA IEPFGGAAT GV GG I IRD I LS MGARPIALLDGLRFG D LDI P GY E - PK G 86
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 371 KL PQ R KLVTTAA AG Y S S YGN Q IG LA T GQVDEIYH P G Y VAKRMEVGAV V AAT P A DH VRR - ET P A PGD KII L L GGRTGRDGI 449
Cdd:cd02203 87 KL SP R RILDGVV AG I S D YGN C IG IP T VGGEVRFD P S Y YGNPLVNVGC V GIV P K DH IVK s KA P G PGD LVV L V GGRTGRDGI 166
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 450 GGAT GA SK AHNVE S L ELD GAE VQ K G NAPV E R KLQ RLFRRGDACR LI KRCN D F GAGG V S V AV G E L A ---- D G LFV DL NT VP 525
Cdd:cd02203 167 GGAT FS SK ELSEN S S ELD RPA VQ V G DPFM E K KLQ EAILEARETG LI VGIQ D L GAGG L S S AV S E M A akgg L G AEI DL DK VP 246
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518557708 526 KKYE G LDGT E LA ISESQERM AVD V AA ED VD EFL TYARE E N LEA T VI AT VT E D P R MVMTWN G DEIVN L 592
Cdd:cd02203 247 LREP G MSPW E IW ISESQERM LLV V PP ED LE EFL AICKK E D LEA A VI GE VT D D G R LRLYYK G EVVAD L 313
GATase_5
pfam13507 CobB/CobQ-like glutamine amidotransferase domain; This family captures members that are not ...
979-1242
1.97e-109
CobB/CobQ-like glutamine amidotransferase domain; This family captures members that are not found in pfam00310, pfam07685 and pfam13230.
Pssm-ID: 463904 [Multi-domain]
Cd Length: 260
Bit Score: 344.10
E-value: 1.97e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 979 KP H V V I PVF PG N N C EY DS AAAFERAG A D VTTLIVNN L TPAA V aestqalve EINKS Q IVMI PGGFS G GD EP d GS A K FIT A 1058
Cdd:pfam13507 1 KP R V A I LRE PG T N G EY EM AAAFERAG F D AVDVHMSD L LSGR V --------- SLDDF Q GLAA PGGFS Y GD VL - GS G K GWA A 70
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 1059 FFR - A P AVTE A VRDLLKNR D GLM LGICNG F Q A L V KLGL V P Y G DIVPMTD a C PTLT F N TI GR HQ SR L V RTRV a S DL SP WLA 1137
Cdd:pfam13507 71 SIL f N P KLRD A FEAFFNRP D TFS LGICNG C Q L L S KLGL I P G G EGDLAER - W PTLT R N DS GR FE SR W V NVKI - S EK SP SVF 148
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 1138 k TSVG D IHTVAIS HGEGRFV A - S D EVLA Q L K ANGQ I A TQ YVD E AG T P GMDLDV NPNGS L L A I E GI T SPDGRV F G K M G H S E 1216
Cdd:pfam13507 149 - LRGM D GSGLPVA HGEGRFV F r S E EVLA R L E ANGQ V A LR YVD N AG N P TEEYPF NPNGS P L G I A GI C SPDGRV L G L M P H P E 227
250 260 270
....*....|....*....|....*....|...
gi 518557708 1217 R SGNGLYVN - V P G ------ NKYQPI F EAGVEYF 1242
Cdd:pfam13507 228 R VFRPWQWP h W P P geweev SPWLRL F RNARKWV 260
PurL2
COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain ...
980-1243
2.43e-109
Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain [Nucleotide transport and metabolism]; Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain is part of the Pathway/BioSystem: Purine biosynthesis
Pssm-ID: 439817 [Multi-domain]
Cd Length: 236
Bit Score: 342.81
E-value: 2.43e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 980 P H V V I P VFPG N NC EY D S AAAFERAGA DVTTLIVNN L tpaavaestqal VEEINKSQIVMI PGGFS G GD EPDGS A KFI taf 1059
Cdd:COG0047 1 P K V A I L VFPG S NC DR D M AAAFERAGA EAEDVWHSD L ------------ RTDLDDFDGLVL PGGFS Y GD YLRAG A IAA --- 65
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 1060 f RA P a VTE AVR DLL k N R D GL M LGICNGFQ A L VK LGL V P y G D ivpmtda C P T LT F N TIG R HQS R L V RT RV ASDL SP WLAKT 1139
Cdd:COG0047 66 - FS P - IMD AVR EFA - R R G GL V LGICNGFQ I L TE LGL L P - G I ------- W P A LT R N RSL R FIC R W V YL RV ENND SP FTSGM 134
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 1140 SV G DIHTVA I S HGEGR F VA SD E V LA Q L K ANGQ I A TQ YVD EA G TPGM dl DV NPNGSL LA I E GIT SP DG R V F G K M G H S ER SG 1219
Cdd:COG0047 135 EA G EVIPIP I A HGEGR Y VA DE E T LA E L E ANGQ V A FR YVD AD G NVTY -- PA NPNGSL NN I A GIT NE DG N V L G M M P H P ER AV 212
250 260
....*....|....*....|....
gi 518557708 1220 NG L YVNVPGNKYQP IF EAG V E YF A 1243
Cdd:COG0047 213 EP L LGPGESTDGLR IF RSA V K YF G 236
PRK01213
PRK01213 phosphoribosylformylglycinamidine synthase subunit PurL;
204-946
2.14e-55
phosphoribosylformylglycinamidine synthase subunit PurL;
Pssm-ID: 234921 [Multi-domain]
Cd Length: 724
Bit Score: 206.49
E-value: 2.14e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 204 GREP TI TE IKVIDTY WS D HC R httfgteldevdiddatvkaafer Y lemrhelg RDA KP vclmdmgtigak W L K K ----- 278
Cdd:PRK01213 26 GREP NF TE LGMFSVM WS E HC S ------------------------ Y -------- KSS KP ------------ L L R K fptkg 61
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 279 NGI L T G LD E seei NA CT V KV kvdvn G EN qd WLFL FK N E T HNHP TEI EP FG GAAT CI GG CI RD PL S grsyvyqa M rvt GA - 357
Cdd:PRK01213 62 PRV L Q G PG E ---- NA GV V DI ----- G DG -- QAVV FK I E S HNHP SAV EP YQ GAAT GV GG IL RD IF S -------- M --- GA r 119
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 358 ---------- ADPTV P VS etlegklpq R K L VTTAA AG YSS YGN Q IG LA T -- G Q V D ei YHPG Y V ------ A kr M E VG A V va 419
Cdd:PRK01213 120 pialldslrf GELDH P KT --------- R Y L LEGVV AG IGG YGN C IG VP T vg G E V Y -- FDES Y N gnplvn A -- M C VG L V -- 184
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 420 at PA D HVRR - ETPAP G DKIILL G GR TGRDGIGGA TG AS K ahnvesl EL DGAE ------ VQ K G NAPV E RK L ---- QR L FRR 488
Cdd:PRK01213 185 -- RH D DIVL a KASGV G NPVVYV G AK TGRDGIGGA SF AS A ------- EL SEES eekrpa VQ V G DPFM E KL L ieac LE L IKT 255
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 489 G dacr L IKRCN D F GA G G VSVAVG E L A D ---- G LFV DL NT VP KKY EG LDGT E LAI SESQERM AVD V AAEDVD E F L TYAREE 564
Cdd:PRK01213 256 G ---- L VVGIQ D M GA A G LTCSSS E M A A kggl G IEL DL DK VP LRE EG MTPY E IML SESQERM LLV V KPGKEE E V L AIFEKW 331
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 565 N L E A T VI AT VT E D P R MVMTWN G DEIVNLSR E F LA SNGASKHQTVHVE A QQGYETPWG E g T L A E RMN K MVTDL N V AS NKGL 644
Cdd:PRK01213 332 D L D A A VI GE VT D D G R LRVYHH G EVVADVPA E A LA DEAPVYDRPYKEP A YLDELQADP E - D L K E ALL K LLSSP N I AS KEWV 410
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 645 S E RF D STIGAG TV LM P F G G krqltpnm A M V AKLP vfg ETTTAS A MAWGF NP --- Y I msk NQFT GA Y L S V V E SLAK L V A A G 721
Cdd:PRK01213 411 Y E QY D HEVQTN TV VK P G G D -------- A A V LRIR --- GGGKGL A LTTDC NP ryv Y L --- DPYE GA K L A V A E AARN L A A V G 476
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 722 ----------- F --- E HEKAYLS F Q E yfeklrdeperwgkpta AV L G - A LMAQV d LG AGAI GG KD S MSGSFEDLDVP PT - 785
Cdd:PRK01213 477 atplaitdcln F gnp E KPEVMWQ F V E ----------------- AV R G l A DACRA - LG TPVV GG NV S LYNETGGTAIY PT p 538
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 786 L I sfa VA VG --- NMKRA T SPE FK GADHR I VRI - APR ------- YL A ------ D G LT P DK D ALL E ------ V FSV I E E -- L 840
Cdd:PRK01213 539 V I --- GM VG lid DVSKR T TSG FK KEGDL I YLL g ETK delggse YL K vihghv G G RP P KV D LEA E krlqel V REA I R E gl V 615
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 841 T DF HD ala VS T pgy G AT A E AL FK M TLGNRI G VTLN --- DSIAVDD LF TPAY G SFI V ELADNAKLP ---- A VSNL V EIGE I 913
Cdd:PRK01213 616 T SA HD --- VS E --- G GL A V AL AE M AIAGGL G AEVD lsd GLRPDAL LF SESQ G RYV V SVPPENEEA feal A EAAG V PATR I 689
810 820 830
....*....|....*....|....*....|...
gi 518557708 914 G TTTSEYAFKAAGE T LD L NAVQ EAWE SGIESVF 946
Cdd:PRK01213 690 G VVGGDALKVKGND T ES L EELR EAWE GALPRLL 722
Name
Accession
Description
Interval
E-value
FGAM-synthase
TIGR01857 phosphoribosylformylglycinamidine synthase, clade II; This model represents a single-molecule ...
3-1242
0e+00
phosphoribosylformylglycinamidine synthase, clade II; This model represents a single-molecule form of phosphoribosylformylglycinamidine synthase, also called FGAM synthase, an enzyme of purine de novo biosynthesis. This model represents a second clade of these enzymes found in Clostridia, Bifidobacteria and Streptococcus species. This enzyme performs the fourth step in IMP biosynthesis (the precursor of all purines) from PRPP. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 130916 [Multi-domain]
Cd Length: 1239
Bit Score: 2246.63
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 3 F RV Y VEKK P GFDVE A Q Q L AG ELR TI LGL TG LK A LRIVN R YDV EGISQ ELF DQ TV P T V FSEP QV D N V AYD L PDF A G - AK V F 81
Cdd:TIGR01857 1 K RV F VEKK A GFDVE S Q S L VK ELR HN LGL SS LK D LRIVN V YDV FDLAE ELF AP TV K T I FSEP VT D H V LDE L SVQ A D l AK F F 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 82 A T EFLPGQFDQRADSA A ECI Q L I S QG E RP TV RS AKLY A L E G E L T D ADVDT IK H Y V INPV EA RE AS L E T KET L KTQVPV P G 161
Cdd:TIGR01857 81 A V EFLPGQFDQRADSA Q ECI L L L S ES E DV TV NT AKLY I L N G D L D D EELNK IK N Y Y INPV DS RE KD L T T GKA L EEFSES P K 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 162 K VET IA GF NEM DAE AGQ KF ID E R GLAM D L A DL E F C Q K YF SEE GR E PT I TEIKV I DTYWSDHCRHTTF G TEL DE V DID D -- 239
Cdd:TIGR01857 161 E VET LT GF ESY DAE DLA KF KA E Q GLAM S L E DL K F I Q D YF KSI GR N PT E TEIKV L DTYWSDHCRHTTF E TEL KH V TFS D sk 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 240 -- ATV K A A F E R YL E MR H ELGR DA KPV C LMDM G TI G AK W L K KNG I L TG L DE SEEINAC T V KVK VDV N G ENQD WL FL FKNET 317
Cdd:TIGR01857 241 fq KQL K K A Y E D YL A MR E ELGR SE KPV T LMDM A TI F AK Y L R KNG K L DD L EV SEEINAC S V EIE VDV D G VKEP WL LM FKNET 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 318 HNHPTEIEPFGGAATCIGG C IRDPLSGRSYVYQAMRVTGA A DPTVP V SETL E GKLPQRK LV TTAA A GYSSYGNQIGLATG 397
Cdd:TIGR01857 321 HNHPTEIEPFGGAATCIGG A IRDPLSGRSYVYQAMRVTGA G DPTVP I SETL K GKLPQRK IT TTAA H GYSSYGNQIGLATG 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 398 QV D EIYHPGYVAKRMEVGAVVAATP ADH V R RE T P A PGD K IILLGG R TGRDGIGGATG A SK A H N VESLEL D GAEVQKGNAP 477
Cdd:TIGR01857 401 QV S EIYHPGYVAKRMEVGAVVAATP KEN V V RE K P E PGD V IILLGG K TGRDGIGGATG S SK E H T VESLEL C GAEVQKGNAP 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 478 V ERK L QRLFR R G DAC RLIK R CNDFGAGGVSVA V GELADGL FV DLN T VPKKYEGL D GTELAISESQERMAV D V AA EDVD E F 557
Cdd:TIGR01857 481 E ERK I QRLFR N G NVT RLIK K CNDFGAGGVSVA I GELADGL EI DLN K VPKKYEGL N GTELAISESQERMAV V V SP EDVD A F 560
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 558 L T Y AR EENLEATV I ATVTE D PR M VM T WNG DE IV N LSR E FL AS NG ASKHQTVH V EAQ ---- QGYETPWGEG TL A E RMN K MV 633
Cdd:TIGR01857 561 L A Y CN EENLEATV V ATVTE K PR L VM N WNG KT IV D LSR R FL DT NG VRQVIDAK V VDK dvkl PEERQKTSAE TL E E DWL K VL 640
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 634 T DLNVAS N KGL S ERFDS TI GAGTVLMP F GGK R QLTP NM A M VAKLPV F - GET T TASA M AWGFNPYI MSKNQFT GA YLS V V E 712
Cdd:TIGR01857 641 S DLNVAS Q KGL Q ERFDS SV GAGTVLMP L GGK Y QLTP TE A S VAKLPV L g GET H TASA I AWGFNPYI AEWSPYH GA AYA V I E 720
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 713 SLAKLVAAG FEHE KA Y LSFQEYFEKL RDEP ERWGKP T AA V LGA LM AQ V DLG AG AIGGKDSMSG S FE D L D VPPTLISFAV A 792
Cdd:TIGR01857 721 SLAKLVAAG ADYK KA R LSFQEYFEKL DKDA ERWGKP F AA L LGA IK AQ I DLG LP AIGGKDSMSG T FE E L T VPPTLISFAV T 800
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 793 VG N MK R AT SPEFK G A DHR I VR I APRY L A DG l T P D K D A L L E V F SV IEEL TDF H DALAV S TPG YG AT AE A L F KMT L GNRIG V 872
Cdd:TIGR01857 801 TA N SR R VI SPEFK A A GEN I YL I PGQA L E DG - T I D F D L L K E N F AQ IEEL IAD H KVVSA S AVK YG GV AE S L A KMT F GNRIG A 879
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 873 T LN DSI a VD DLFT PA YGSFI V E LADN aklpav SNLVEIGE IG T TT SEYAF K AA GE T LDL NAVQE AWE SGI E S VFP Y rs K G 952
Cdd:TIGR01857 880 E LN NPE - LE DLFT AQ YGSFI F E SPEE ------ LSIANVEK IG Q TT ADFVL K VN GE K LDL EELES AWE GKL E E VFP S -- K F 950
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 953 EDK GK TVE TIDFHAP KK TAYTGSS V A KP H VVIPVFPG N N C EYDSA A AFE RA GA D V TTL I VN NL TPA A VA ES TQAL V E EI N 1032
Cdd:TIGR01857 951 EDK KE TVE VPAVASE KK VIKAKEK V E KP R VVIPVFPG T N S EYDSA K AFE KE GA E V NLV I FR NL NEE A LV ES VETM V D EI D 1030
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 1033 KSQI V M I PGGFS G GDEPDGSAKFI T A FF R A P A V TE A VRDL L k N RDGL M LGICNGFQALVK L GL V PYG D I VPMTDAC PTLT 1112
Cdd:TIGR01857 1031 KSQI L M L PGGFS A GDEPDGSAKFI A A IL R N P K V RV A IDSF L - A RDGL I LGICNGFQALVK S GL L PYG N I EAANETS PTLT 1109
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 1113 F N T I G RH Q S RL VRTR V AS DL SPWL AKT SVGDIH TVAI SHGEGRFVASDEVLA Q L KA NGQIATQYVD EA G T P G MD LDV NPN 1192
Cdd:TIGR01857 1110 Y N D I N RH V S KI VRTR I AS TN SPWL SGV SVGDIH AIPV SHGEGRFVASDEVLA E L RE NGQIATQYVD FN G K P S MD SKY NPN 1189
1210 1220 1230 1240 1250
....*....|....*....|....*....|....*....|....*....|
gi 518557708 1193 GS L LAIEGITSPDGR V FGKMGHSER S G N GL YV N V PGNK Y Q PI F EA GV E YF 1242
Cdd:TIGR01857 1190 GS S LAIEGITSPDGR I FGKMGHSER Y G D GL FK N I PGNK D Q HL F AS GV K YF 1239
PurL_repeat1
cd02203 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. ...
211-592
5.11e-133
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100034 [Multi-domain]
Cd Length: 313
Bit Score: 408.78
E-value: 5.11e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 211 E IKVIDTY WS D HCRH TT F GTE L DEV diddatvkaaferylemrhelgrdakpvclmdmgtigakwlkkngiltgldesee 290
Cdd:cd02203 1 E LGMFAQM WS E HCRH KS F KSL L KMI ------------------------------------------------------- 25
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 291 inactvkvkvdvngenqd W LFL FK N ETHNHP TE IEPFGGAAT CI GG C IRD P LS GRSYVYQAMRVTGAA D PTV P VS E t LE G 370
Cdd:cd02203 26 ------------------ W AVV FK V ETHNHP SA IEPFGGAAT GV GG I IRD I LS MGARPIALLDGLRFG D LDI P GY E - PK G 86
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 371 KL PQ R KLVTTAA AG Y S S YGN Q IG LA T GQVDEIYH P G Y VAKRMEVGAV V AAT P A DH VRR - ET P A PGD KII L L GGRTGRDGI 449
Cdd:cd02203 87 KL SP R RILDGVV AG I S D YGN C IG IP T VGGEVRFD P S Y YGNPLVNVGC V GIV P K DH IVK s KA P G PGD LVV L V GGRTGRDGI 166
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 450 GGAT GA SK AHNVE S L ELD GAE VQ K G NAPV E R KLQ RLFRRGDACR LI KRCN D F GAGG V S V AV G E L A ---- D G LFV DL NT VP 525
Cdd:cd02203 167 GGAT FS SK ELSEN S S ELD RPA VQ V G DPFM E K KLQ EAILEARETG LI VGIQ D L GAGG L S S AV S E M A akgg L G AEI DL DK VP 246
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518557708 526 KKYE G LDGT E LA ISESQERM AVD V AA ED VD EFL TYARE E N LEA T VI AT VT E D P R MVMTWN G DEIVN L 592
Cdd:cd02203 247 LREP G MSPW E IW ISESQERM LLV V PP ED LE EFL AICKK E D LEA A VI GE VT D D G R LRLYYK G EVVAD L 313
GATase_5
pfam13507 CobB/CobQ-like glutamine amidotransferase domain; This family captures members that are not ...
979-1242
1.97e-109
CobB/CobQ-like glutamine amidotransferase domain; This family captures members that are not found in pfam00310, pfam07685 and pfam13230.
Pssm-ID: 463904 [Multi-domain]
Cd Length: 260
Bit Score: 344.10
E-value: 1.97e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 979 KP H V V I PVF PG N N C EY DS AAAFERAG A D VTTLIVNN L TPAA V aestqalve EINKS Q IVMI PGGFS G GD EP d GS A K FIT A 1058
Cdd:pfam13507 1 KP R V A I LRE PG T N G EY EM AAAFERAG F D AVDVHMSD L LSGR V --------- SLDDF Q GLAA PGGFS Y GD VL - GS G K GWA A 70
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 1059 FFR - A P AVTE A VRDLLKNR D GLM LGICNG F Q A L V KLGL V P Y G DIVPMTD a C PTLT F N TI GR HQ SR L V RTRV a S DL SP WLA 1137
Cdd:pfam13507 71 SIL f N P KLRD A FEAFFNRP D TFS LGICNG C Q L L S KLGL I P G G EGDLAER - W PTLT R N DS GR FE SR W V NVKI - S EK SP SVF 148
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 1138 k TSVG D IHTVAIS HGEGRFV A - S D EVLA Q L K ANGQ I A TQ YVD E AG T P GMDLDV NPNGS L L A I E GI T SPDGRV F G K M G H S E 1216
Cdd:pfam13507 149 - LRGM D GSGLPVA HGEGRFV F r S E EVLA R L E ANGQ V A LR YVD N AG N P TEEYPF NPNGS P L G I A GI C SPDGRV L G L M P H P E 227
250 260 270
....*....|....*....|....*....|...
gi 518557708 1217 R SGNGLYVN - V P G ------ NKYQPI F EAGVEYF 1242
Cdd:pfam13507 228 R VFRPWQWP h W P P geweev SPWLRL F RNARKWV 260
PurL2
COG0047 Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain ...
980-1243
2.43e-109
Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain [Nucleotide transport and metabolism]; Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain is part of the Pathway/BioSystem: Purine biosynthesis
Pssm-ID: 439817 [Multi-domain]
Cd Length: 236
Bit Score: 342.81
E-value: 2.43e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 980 P H V V I P VFPG N NC EY D S AAAFERAGA DVTTLIVNN L tpaavaestqal VEEINKSQIVMI PGGFS G GD EPDGS A KFI taf 1059
Cdd:COG0047 1 P K V A I L VFPG S NC DR D M AAAFERAGA EAEDVWHSD L ------------ RTDLDDFDGLVL PGGFS Y GD YLRAG A IAA --- 65
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 1060 f RA P a VTE AVR DLL k N R D GL M LGICNGFQ A L VK LGL V P y G D ivpmtda C P T LT F N TIG R HQS R L V RT RV ASDL SP WLAKT 1139
Cdd:COG0047 66 - FS P - IMD AVR EFA - R R G GL V LGICNGFQ I L TE LGL L P - G I ------- W P A LT R N RSL R FIC R W V YL RV ENND SP FTSGM 134
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 1140 SV G DIHTVA I S HGEGR F VA SD E V LA Q L K ANGQ I A TQ YVD EA G TPGM dl DV NPNGSL LA I E GIT SP DG R V F G K M G H S ER SG 1219
Cdd:COG0047 135 EA G EVIPIP I A HGEGR Y VA DE E T LA E L E ANGQ V A FR YVD AD G NVTY -- PA NPNGSL NN I A GIT NE DG N V L G M M P H P ER AV 212
250 260
....*....|....*....|....
gi 518557708 1220 NG L YVNVPGNKYQP IF EAG V E YF A 1243
Cdd:COG0047 213 EP L LGPGESTDGLR IF RSA V K YF G 236
PurL1
COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and ...
171-946
2.23e-88
Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain is part of the Pathway/BioSystem: Purine biosynthesis
Pssm-ID: 439816 [Multi-domain]
Cd Length: 747
Bit Score: 303.12
E-value: 2.23e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 171 E MDA EA GQKFID E R GLA md L A D L E F c QKYFSEE GR E PT IT E IKVIDTY WS D HC RHTTF gteldevdiddatv K A AFERY l 250
Cdd:COG0046 7 E GGR EA LEEANR E L GLA -- L S D D E Y - DYIVEIL GR N PT DV E LGMFSQM WS E HC SYKSS -------------- N A LLKSL - 68
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 251 emrhelgrdakpvclmdmgtigak WLKKNGI L T G LDE seei NA CT V KV kvdvnge NQDWLFL FK N E T HNHP TE IEP FG GA 330
Cdd:COG0046 69 ------------------------ PTEGPRV L S G PGD ---- NA GV V DI ------- GDGLAVV FK V E S HNHP SA IEP YQ GA 113
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 331 AT CI GG C IRD PLS grsyvyqa M rvt GA ----------- ADPTV P VSETLE gklpqrk LVTTAA AG YSS YGN QI G LA T -- G 397
Cdd:COG0046 114 AT GV GG I IRD IFG -------- M --- GA rpiagldslrf GNLDQ P PASPRY ------- ILIGVV AG IAD YGN CF G VP T vg G 175
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 398 qvd E IY - HPG Y VAKR - MEV G A V v AATP ADH VRR - ET P AP G D K IILL GG R TGRDGIGGAT G AS KAHNVE S l ELD GAE VQ K G 474
Cdd:COG0046 176 --- E VR f DES Y EGNP l VNA G G V - GIIR ADH IFK a KA P GV G N K VVYV GG P TGRDGIGGAT F AS EELGED S - ELD RPA VQ V G 250
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 475 NAPV E RK L Q rlfrrg D A CR ------ LI KRCN D F GAGG V S V A VG E L A D ---- G LFV DL NT VP KKYE G LDGT E LAI SESQER 544
Cdd:COG0046 251 DPFM E KR L I ------ E A IL elgdtg LI VGIQ D M GAGG L S S A SS E M A A kggl G AEI DL DK VP LREP G MSPY E IWL SESQER 324
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 545 M AVD V AA E DVD EF LTYAREEN L E A T VI AT VT E D P R M V M T WN G DEIVN L SRE FLA SNGASK H - QTVHVEAQQGYET P w GEG 623
Cdd:COG0046 325 M LLV V KP E KLE EF EAIFERWR L P A A VI GE VT D D G R L V V T DH G ETVAD L PLD FLA GGAPKY H r PAKRPAYLEPLDL P - EPI 403
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 624 T L A E RMNKMVTDL NVAS NKG L SERF D STI G AG TV LM P fggkrql TPNM A M V AKL pvf GE T TTAS AM AW G F NP YIMSKNQF 703
Cdd:COG0046 404 D L E E ALLRLLSSP NVAS KEW L YRQY D REV G GN TV RD P ------- GVAD A A V VRV --- DG T YKGL AM ST G E NP RYALLDPY 473
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 704 T GA YLS V V E SLAK L V A A G F E HEKAYLSFQ eyfeklrdeper WG K P T --------- A AV L G al M A QV -- D LG AGAIG G KD S 772
Cdd:COG0046 474 A GA RMA V A E AARN L A A V G A E PLAITDCLN ------------ WG N P E kpeemaqlv E AV K G -- L A DA cr A LG IPVPS G NV S 539
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 773 MSGSFE D LD V -- PPT LISF AV A - V GNMKRATS P EF K GADHRIVR I --- APR ----- Y LA ----- D G LT PD K D ALL E -- V F 834
Cdd:COG0046 540 LYNETK D GK V ai PPT PVIG AV G l V DDVRKTVT P DL K KEGDLLYL I get KNE lggse Y AQ vlgql G G EP PD V D LEA E ka L F 619
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 835 SVIE EL TD ------ F HD ala VS TP G YGA tae AL FK M TLGNRI G VTLN ----- D SIAVDD LF TPAY G SFI V EL A D n AKLP A 903
Cdd:COG0046 620 EAVQ EL IR eglila A HD --- VS DG G LAV --- AL AE M AFAGGL G ADID ldalg D LRPDAA LF SESQ G RAV V QV A P - EDAE A 692
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|...
gi 518557708 904 V SN L ----- VEIGE IGT T T SEYAF -- KAA GETL --- D L NAVQE AWE SGIESVF 946
Cdd:COG0046 693 V EA L laeag LPAHV IGT V T GDDRL vi RRG GETL lsl S L AELRD AWE ETLPRLR 745
GATase1_FGAR_AT
cd01740 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ...
982-1239
2.93e-83
Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase (FGAR-AT). FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, Pi, and glutamate in the fourth step of the purine biosynthetic pathway. FGAR-AT is a glutamine amidotransferase. Glutamine amidotransferase activity catalyses the transfer of ammonia from the amide side chain of glutamine to an acceptor substrate. FGAR-AT belongs to the triad family of amidotransferases having a conserved Cys-His-Glu catalytic triad in the glutaminase active site
Pssm-ID: 153211 [Multi-domain]
Cd Length: 238
Bit Score: 271.41
E-value: 2.93e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 982 V VIPV FPG N NC EY D S A A AFE R AG ADVTTLIV N N L T paavaestq A LVEEINKSQI V MI PGGFS G GD EPDGS A KFITAFFR 1061
Cdd:cd01740 1 V AVLR FPG S NC DR D M A Y AFE L AG FEAEDVWH N D L L --------- A GRKDLDDYDG V VL PGGFS Y GD YLRAG A IAAASPLL 71
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 1062 APA V T E AVR dllkn R D GL M LGICNGFQ A LV K LGL V P YGD I VP mtdac PT L T F NT ig R H Q S R L V RT RV ASDL SP WLAKTSV 1141
Cdd:cd01740 72 MEE V K E FAE ----- R G GL V LGICNGFQ I LV E LGL L P GAL I RN ----- KG L K F IC -- R W Q N R F V TL RV ENND SP FTKGYME 139
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 1142 G DIHTVAIS HGEGRF V A S DE V LA Q L KA NGQIA t QYVD EA G TPGMDLDV NPNGSL LA I E GI TSP DGRV F G K M G H S ER SGNG 1221
Cdd:cd01740 140 G EVLRIPVA HGEGRF Y A D DE T LA E L EE NGQIA - QYVD DD G NVTERYPA NPNGSL DG I A GI CNE DGRV L G M M P H P ER AVEP 218
250 260
....*....|....*....|
gi 518557708 1222 LY -- VNVP G NKYQPI F EAG V 1239
Cdd:cd01740 219 WQ we RLLG G SDGLKL F RNA V 238
FGAM_synt
TIGR01735 phosphoribosylformylglycinamidine synthase, single chain form; This model represents a ...
118-1217
2.78e-78
phosphoribosylformylglycinamidine synthase, single chain form; This model represents a single-molecule form of phosphoribosylformylglycinamidine synthase, also called FGAM synthase, an enzyme of purine de novo biosynthesis. This form is found mostly in eukaryotes and Proteobacteria. In Bacillus subtilis PurL (FGAM synthase II) and PurQ (FGAM synthase I), homologous to different parts of this model, perform the equivalent function; the unrelated small protein PurS is also required and may be a third subunit. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 188163 [Multi-domain]
Cd Length: 1310
Bit Score: 283.22
E-value: 2.78e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 118 Y A L E G E -- L TDADVDTIKHYVINPVE ar E AS L ETKETLKT -- Q VP V P GKVE TI AGFNE m DAE A GQ K FID E R GLA M D LADL 193
Cdd:TIGR01735 111 Y Y L S G A hp L SEEQEAQAAALLHDRMT -- E SV L PHEIEAFE lf S VP E P LNLT TI DVLGG - GRL A LE K ANQ E L GLA L D EDEI 187
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 194 EFCQ K Y F S E EG R E P TIT E IKVIDTYW S D HCRH TT F GTELD evd ID DA tvkaaferyl EMRHE L grdakpvclmd MGT I GA 273
Cdd:TIGR01735 188 DYLT K R F Q E LQ R N P SDV E LMMFAQAN S E HCRH KI F NADWI --- ID GK ---------- KQDKS L ----------- FQM I KS 243
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 274 KW - LKKNGILTGL - D E S EE I NACT V K ------- VKVDVNGENQ D WL - F L F K N ETHNHPT E I E PF G GA A T CI GG C IRD --- 340
Cdd:TIGR01735 244 TH e ANPENTVSAY k D N S SV I EGHK V G rlrpdpp TRPEYRQHQE D LV h I L M K V ETHNHPT A I A PF P GA S T GA GG E IRD ega 323
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 341 ------ P LS G RS - YVYQAMRVT G AAD P T vpvs E TLEG K l P Q R ----- KLVTT A AA G YSSYG N QI G --------------- 393
Cdd:TIGR01735 324 tgrgak P KA G LT g FCVSNLNIP G LEQ P W ---- E DPFQ K - P E R iaspl DIMIE A PL G AAAFN N EF G rpnllgyfrtfelka 398
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 394 - L AT GQV DE i YH pgyva K RMEVGAVVAATP A D H VRRETPA PG DKI I L LGG RTGRD G I GG ATGA S KAHNVESLE LD G A E VQ 472
Cdd:TIGR01735 399 s L PG GQV RG - YH ----- K PIMLAGGIGSID A E H IQKGEIE PG ALL I V LGG PAMLI G L GG GAAS S MVSGTNTAD LD F A S VQ 472
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 473 K GN APV ER KL Q RLFR R ---- G DA c RL I KRCN D F GAGG V S V A VG EL AD ---- G LFV DL NT VP KKYE GL DGT E LAIS ESQER 544
Cdd:TIGR01735 473 R GN PEM ER RC Q EVID R cwql G EK - NP I ISIH D V GAGG L S N A LP EL IH dggr G AVI DL RA VP LDDP GL SPL E IWCN ESQER 551
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 545 MAVD V A AE DVDE F LTYARE E NLEAT V IA T V T E D P R MVM -------- TWN GD EI ------- V N L SR E F L ASNGASKHQT V H 609
Cdd:TIGR01735 552 YVLL V R AE NLEI F TAICER E RCPFA V VG T A T G D G R LTL vddtpvrr NGQ GD AP shfpnnp V D L PL E V L LGKMPKMTRF V Q 631
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 610 VE A QQGYETPWGE G - T L A E RMNKMVTDLN VAS NKG L SERF D STI G AGTVLMPFG G KR Q LT pn M A M VA KLPVFGE T T T AS A 688
Cdd:TIGR01735 632 RK A PMLQPLDIPP G l D L H E ALERVLRLPA VAS KRF L ITIG D RSV G GLVARDQMV G PW Q TP -- L A D VA VTAASFD T Y T GE A 709
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 689 MA W G FN P YIMSKNQFTG A Y L S V V E SLAK L V AA GFEHEK - AY LS FQ - EYFEKLRD E PERWGKPTA AV L g A L MAQVDL gag A 766
Cdd:TIGR01735 710 MA I G ER P PKALLDPKAS A R L A V G E AITN L A AA LVGDLS d VK LS AN w MAAAGHPG E DAALYDAVK AV S - E L CPALGI --- A 785
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 767 I - G GKDS M S -------- G SFEDLDV P PT L - IS FAVA V GNMKRATS P EF K GADHRIV ----------- R IAPRY LA D ---- 821
Cdd:TIGR01735 786 I p V GKDS L S mktrwqdn G ETKSVTA P GS L v IS AFAP V PDVRKTVT P DL K HDKGDSH lllvdlgpgkn R LGGSA LA Q vfgq 865
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 822 -- G LT PD K D A --- L LEV F S V IEE L TDFHDA LA VSTPGY G ATAEA L FK M TLGNRI G VTLN - D SIAVDD --- LF TPAY G S f I 892
Cdd:TIGR01735 866 lg G DC PD L D D per L KAF F A V MQG L VAEGLL LA YHDRSD G GLVTT L LE M AFAGHC G LDVD l D ALGDSL fav LF NEEL G A - V 944
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 893 VEL A DNA k L P AV SN L VE ------- I GE IGT T T SEYAF -- KAA G E TL --- DLNAVQEA WE SGIESVFPY R SKG E DKGKTV E 960
Cdd:TIGR01735 945 IQV A KPD - L A AV LE L LR aagltal I LG IGT P T GHPMI ri SVN G A TL lse KRSELRDI WE ETSFQLQRL R DNP E CAEEEF E 1023
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 961 TI - D FHA P KKTAYTGSS V A ------------ KP H V V I PVFP G N N CEYDS AAAF E RAG ADVTTLIVNN L tpaavaestqa L 1027
Cdd:TIGR01735 1024 GL r D RDG P GLKLPLTFD V N ediaapfinkgv KP K V A I LREQ G V N GDREM AAAF D RAG FEAWDVHMSD L ----------- L 1092
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 1028 VEEINKSQIVMIP -- GGFS G GD EPD --- G S AK F I T af F R a P AVTEAVRDLL K NR D GLM LG I CNG F Q A L VK L glvpy GDIV 1102
Cdd:TIGR01735 1093 AGRVHLDEFRGLA ac GGFS Y GD VLG agk G W AK S I L -- F N - P RLRDQFQAFF K RP D TFS LG V CNG C Q M L SN L ----- LEWI 1164
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 1103 P M T DAC P TLTF N TIG R HQS R LVRT RV ASDL S PW L AKTS v G DIHT VA IS HGEG R - FVA S D E VL AQ LK A N G QI A TQ Y V D EA G 1181
Cdd:TIGR01735 1165 P G T ENW P HFVR N NSE R FEA R VASV RV GESP S IM L RGMA - G SRLP VA VA HGEG Y a AFS S P E LQ AQ AD A S G LA A LR Y I D DD G 1243
1210 1220 1230
....*....|....*....|....*....|....*.
gi 518557708 1182 T P GMDLDV NPNGS LLA I E GITS P DGRV FGK M G H S ER 1217
Cdd:TIGR01735 1244 N P TEAYPL NPNGS PGG I A GITS C DGRV TIM M P H P ER 1279
FGAM_synth_II
TIGR01736 phosphoribosylformylglycinamidine synthase II; Phosphoribosylformylglycinamidine synthase is a ...
188-943
5.03e-72
phosphoribosylformylglycinamidine synthase II; Phosphoribosylformylglycinamidine synthase is a single, long polypeptide in most Proteobacteria and eukarotes. Three proteins are required in Bacillus subtilis and many other species. This is the longest of the three and is designated PurL, phosphoribosylformylglycinamidine synthase II, or FGAM synthase II. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 273781 [Multi-domain]
Cd Length: 715
Bit Score: 255.69
E-value: 5.03e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 188 MDLADL E FCQK yfs EE GREP TI TE IKVIDTY WS D HC RH ttfgteldevdiddatvkaaferylemrhelg RDA K P vc L MD 267
Cdd:TIGR01736 1 LSDEEM E LIRE --- IL GREP ND TE LAMFSAM WS E HC SY -------------------------------- KSS K K -- L LK 43
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 268 MGTIGAKW lkkng ILT G LD E seei N A CT V KVK vdvngen QDWLFL FK N E T HNHP TE IEP FG GAAT CI GG CI RD P LS GRSY 347
Cdd:TIGR01736 44 QFPTKGPN ----- VIQ G PG E ---- D A GV V DIG ------- DGYAVV FK M E S HNHP SA IEP YN GAAT GV GG IL RD I LS MGAR 107
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 348 VYQAMRVTGAADPTV P vsetlegkl PQ R K L VTTAA AG Y S S YGN Q IG LA T -- G Q V D ei YHPG Y VAKRM - E V GA V VAATPA D 424
Cdd:TIGR01736 108 PIALLDSLRFGPLDD P --------- KN R Y L FEGVV AG I S D YGN R IG VP T vg G E V E -- FDES Y NGNPL v N V MC V GLVRKD D 176
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 425 H V RRETPA PG D K II L L GG R TGRDGIGGAT G AS KAHNV E SL E L D GAE VQ K G NAPV E RK L QRLFRRGDACR L I K RCN D F GA G 504
Cdd:TIGR01736 177 I V TGKAKG PG N K LV L V GG K TGRDGIGGAT F AS EELSE E AE E E D RPA VQ V G DPFT E KL L IEATLEAVDTG L V K GIK D L GA A 256
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 505 G VSV A VG E L A D ---- G LFVD L NT VP KKYE G LDGT E LAI SESQERM AVD VA A EDV D E F L TYAREEN L E A T VI AT VT EDP R M 580
Cdd:TIGR01736 257 G LTS A SS E M A A kggl G AEIY L DK VP LREP G MTPY E IML SESQERM LLV VA P EDV E E V L EIFEKYE L P A S VI GE VT DEG R I 336
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 581 VMTWN G DEIVN L SR E F LA SNGASKHQTVHVEAQQGYET P WGEGT L AERMN K MVTDL N V AS NKGLSERF D STIGAG TV LM P 660
Cdd:TIGR01736 337 RLYYK G EVVAD L PI E L LA DAPEYERPSEPPKYPEEEKE P EPPAD L EDAFL K VLSSP N I AS KEWVYRQY D HEVQTR TV VK P 416
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 661 FGG krqltpnm A M V AKLP vf GETTTAS A MAWGF NP YIMSKNQFT GA YLS V V E SLAK L V A A G ----------- F --- E HEK 726
Cdd:TIGR01736 417 GED -------- A A V LRIK -- ETGKLGL A LTADC NP RYVYLDPYA GA AGA V A E AYRN L A A V G aeplaavdcln F gnp E RPE 486
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 727 A Y LS F Q E YFEK L R D EPERW G K P T aavlgalmaqvdlgaga I GG KD S MSGSFEDLDVP PT LISFA V A - V GNMKRATSPE FK 805
Cdd:TIGR01736 487 V Y WQ F V E AVKG L G D ACRAL G T P V ----------------- V GG NV S LYNETNGVPIA PT PTIGM V G l V EDVEKLLTSN FK 549
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 806 GADHR I VR I -------- APR YL A ------ D G LT P -- D KDALL E VFSVIE E LTDFHDAL A VSTPGY G AT A E AL FK M TLGNR 869
Cdd:TIGR01736 550 KEGDA I YL I getkdelg GSE YL R vihgiv S G QV P av D LEEEK E LADAVR E AIRAGLVS A AHDVSR G GL A V AL AE M AAASG 629
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 870 IG VTL ----- NDSIAVDD LF TPAY G SF IV ELADNAKLP AV - S NL V EIGE IG T T TSEY - AF K AAGE T LDLNA -- VQE AWE S 940
Cdd:TIGR01736 630 IG AEV didei ASARPDEL LF SESN G RA IV AVPEEKAEE AV k S KG V PAKV IG K T GGDR l TI K TGDD T ISVSV ke LRD AWE E 709
...
gi 518557708 941 GIE 943
Cdd:TIGR01736 710 ALP 712
PurL_repeat2
cd02204 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. ...
672-916
3.40e-59
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100035 [Multi-domain]
Cd Length: 264
Bit Score: 204.69
E-value: 3.40e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 672 A M V AKL P vf GET TTAS AM AW G F NP YIMSKNQFT GA Y L S V V E SLAK LVA A G FEH e K A YLSFQEYFEKLRD E p ERW G KPTA A 751
Cdd:cd02204 2 A A V LRI P -- GET DKGL AM ST G E NP RYSLLDPYA GA A L A V A E AVRN LVA V G ADP - L A ITDCLNFGNPEKP E - GEM G QLVE A 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 752 VLG ALM A QVD LG AGA IGGKDS MSGSF E DLDV PPTL ISF AV A - V GNMKRATSPE FK GADHRIVR I APRYLAD G L ------- 823
Cdd:cd02204 78 VLG LGD A CRA LG TPV IGGKDS LYNET E GVAI PPTL VIG AV G v V DDVRKIVTLD FK KEGDLLYL I GETKDEL G G seyalay 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 824 --------- TP D KDALLEV F SVIE EL TDFHDA L AVSTPGY G AT A E AL FK M TLGNRI G VTLN --- D SIAVDD LF TPAY G SF 891
Cdd:cd02204 158 hglgggapp LV D LEREKAL F DAVQ EL IKEGLV L SAHDVSD G GL A V AL AE M AFAGGL G AEVD lsk D DAEDEL LF SESL G RV 237
250 260
....*....|....*....|....*..
gi 518557708 892 I VE LADN -- AKLP A VSNL V EIGE IGT T 916
Cdd:cd02204 238 L VE VKPE ne EVFE A EEAG V PATV IGT V 264
PRK01213
PRK01213 phosphoribosylformylglycinamidine synthase subunit PurL;
204-946
2.14e-55
phosphoribosylformylglycinamidine synthase subunit PurL;
Pssm-ID: 234921 [Multi-domain]
Cd Length: 724
Bit Score: 206.49
E-value: 2.14e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 204 GREP TI TE IKVIDTY WS D HC R httfgteldevdiddatvkaafer Y lemrhelg RDA KP vclmdmgtigak W L K K ----- 278
Cdd:PRK01213 26 GREP NF TE LGMFSVM WS E HC S ------------------------ Y -------- KSS KP ------------ L L R K fptkg 61
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 279 NGI L T G LD E seei NA CT V KV kvdvn G EN qd WLFL FK N E T HNHP TEI EP FG GAAT CI GG CI RD PL S grsyvyqa M rvt GA - 357
Cdd:PRK01213 62 PRV L Q G PG E ---- NA GV V DI ----- G DG -- QAVV FK I E S HNHP SAV EP YQ GAAT GV GG IL RD IF S -------- M --- GA r 119
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 358 ---------- ADPTV P VS etlegklpq R K L VTTAA AG YSS YGN Q IG LA T -- G Q V D ei YHPG Y V ------ A kr M E VG A V va 419
Cdd:PRK01213 120 pialldslrf GELDH P KT --------- R Y L LEGVV AG IGG YGN C IG VP T vg G E V Y -- FDES Y N gnplvn A -- M C VG L V -- 184
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 420 at PA D HVRR - ETPAP G DKIILL G GR TGRDGIGGA TG AS K ahnvesl EL DGAE ------ VQ K G NAPV E RK L ---- QR L FRR 488
Cdd:PRK01213 185 -- RH D DIVL a KASGV G NPVVYV G AK TGRDGIGGA SF AS A ------- EL SEES eekrpa VQ V G DPFM E KL L ieac LE L IKT 255
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 489 G dacr L IKRCN D F GA G G VSVAVG E L A D ---- G LFV DL NT VP KKY EG LDGT E LAI SESQERM AVD V AAEDVD E F L TYAREE 564
Cdd:PRK01213 256 G ---- L VVGIQ D M GA A G LTCSSS E M A A kggl G IEL DL DK VP LRE EG MTPY E IML SESQERM LLV V KPGKEE E V L AIFEKW 331
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 565 N L E A T VI AT VT E D P R MVMTWN G DEIVNLSR E F LA SNGASKHQTVHVE A QQGYETPWG E g T L A E RMN K MVTDL N V AS NKGL 644
Cdd:PRK01213 332 D L D A A VI GE VT D D G R LRVYHH G EVVADVPA E A LA DEAPVYDRPYKEP A YLDELQADP E - D L K E ALL K LLSSP N I AS KEWV 410
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 645 S E RF D STIGAG TV LM P F G G krqltpnm A M V AKLP vfg ETTTAS A MAWGF NP --- Y I msk NQFT GA Y L S V V E SLAK L V A A G 721
Cdd:PRK01213 411 Y E QY D HEVQTN TV VK P G G D -------- A A V LRIR --- GGGKGL A LTTDC NP ryv Y L --- DPYE GA K L A V A E AARN L A A V G 476
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 722 ----------- F --- E HEKAYLS F Q E yfeklrdeperwgkpta AV L G - A LMAQV d LG AGAI GG KD S MSGSFEDLDVP PT - 785
Cdd:PRK01213 477 atplaitdcln F gnp E KPEVMWQ F V E ----------------- AV R G l A DACRA - LG TPVV GG NV S LYNETGGTAIY PT p 538
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 786 L I sfa VA VG --- NMKRA T SPE FK GADHR I VRI - APR ------- YL A ------ D G LT P DK D ALL E ------ V FSV I E E -- L 840
Cdd:PRK01213 539 V I --- GM VG lid DVSKR T TSG FK KEGDL I YLL g ETK delggse YL K vihghv G G RP P KV D LEA E krlqel V REA I R E gl V 615
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 841 T DF HD ala VS T pgy G AT A E AL FK M TLGNRI G VTLN --- DSIAVDD LF TPAY G SFI V ELADNAKLP ---- A VSNL V EIGE I 913
Cdd:PRK01213 616 T SA HD --- VS E --- G GL A V AL AE M AIAGGL G AEVD lsd GLRPDAL LF SESQ G RYV V SVPPENEEA feal A EAAG V PATR I 689
810 820 830
....*....|....*....|....*....|...
gi 518557708 914 G TTTSEYAFKAAGE T LD L NAVQ EAWE SGIESVF 946
Cdd:PRK01213 690 G VVGGDALKVKGND T ES L EELR EAWE GALPRLL 722
PRK05297
PRK05297 phosphoribosylformylglycinamidine synthase; Provisional
118-1218
1.11e-54
phosphoribosylformylglycinamidine synthase; Provisional
Pssm-ID: 235394 [Multi-domain]
Cd Length: 1290
Bit Score: 209.27
E-value: 1.11e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 118 Y AL E GE L TDADVDTIKHYVINP - V E ARE A S L ETK E T L KTQVP v P GKVETI --- A G FNEMDAE A GQKF ider GLA MDLADL 193
Cdd:PRK05297 109 Y YV E AA L SAEQRAALAALLHDR m T E SVF A D L DDA E A L FSHHE - P KPLTSV dvl G G GRAALEA A NVEL ---- GLA LAEDEI 183
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 194 EFCQKY F SEE GR E PT IT E IKVIDTYW S D HCRH TT F GTELD evd ID DA tvkaaferylemrhelgrd AK P VC L MD M ----- 268
Cdd:PRK05297 184 DYLVEA F TKL GR N PT DV E LMMFAQAN S E HCRH KI F NADWT --- ID GE ------------------- EQ P KS L FK M iknth 241
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 269 ----- G TIG A kw L K K N - GILT G l DESEEINACTVKVKVDVNG E NQD wl F L F K N ETHNHPT E I E PF G GAAT CI GG C IRD -- 340
Cdd:PRK05297 242 etnpd G VLS A -- Y K D N a AVME G - SKVGRFFPDPDTGRYGYHQ E PAH -- I L M K V ETHNHPT A I S PF P GAAT GS GG E IRD eg 316
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 341 ------- P LS G R ----- S Y vyqa M R VT G AAD P T vpvs E TLE GK l P Q R ----- KLVTTAAA G YSSYG N QI G ---------- 393
Cdd:PRK05297 317 atgrgsk P KA G L tgfsv S N ---- L R IP G FEQ P W ---- E EDY GK - P E R iasal DIMIEGPL G GAAFN N EF G rpnllgyfrt 387
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 394 --- LATGQVD E IY hp GY VAKR M EV G AVVAAT p ADHV RRETPAP G D K I I L LGG RTG R D G I GG ------ A T G A S KA hnvesl 464
Cdd:PRK05297 388 feq KVNSHNE E VR -- GY HKPI M LA G GIGNIR - ADHV QKGEIPV G A K L I V LGG PAM R I G L GG gaassm A S G Q S SE ------ 458
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 465 E LD G A E VQ K GN APV ER KL Q RLFR R ---- GD A c RL I KRCN D F GAGG V S V A VG EL AD ----- G L F v DL NTV P KKYE G LDGT E 535
Cdd:PRK05297 459 D LD F A S VQ R GN PEM ER RC Q EVID R cwql GD D - NP I LSIH D V GAGG L S N A FP EL VN dggrg G R F - DL RKI P NDEP G MSPL E 536
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 536 LAIS ESQER MAVDV A A ED VDE F LTYARE E NLEAT V IATV TE DPRMVM -- TWNGDEI V N L SREF L ASNGASK H QT V HVEAQ 613
Cdd:PRK05297 537 IWCN ESQER YVLAI A P ED LEL F EAICER E RCPFA V VGEA TE ERHLTL ed SHFDNKP V D L PLDV L LGKPPKM H RD V KTVKA 616
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 614 Q G YETPWGEGT LAE RMNKMVTDLN VAS nkgls ER F DS TIG AGT V lmpf G G krqltpnma M VA K -------- L PV ------ 679
Cdd:PRK05297 617 K G PALDYSGID LAE AVERVLRLPT VAS ----- KS F LI TIG DRS V ---- T G --------- L VA R dqmvgpwq V PV adcavt 678
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 680 ------- F GE tttas AMA W G FNPYIMSKNQFTG A YLS V V E S L AKLV AA ------------------ G FEH E K A Y L sfqey 734
Cdd:PRK05297 679 aasydgy A GE ----- AMA M G ERTPVALLDAAAS A RMA V G E A L TNIA AA pigdlkriklsanwmaaa G HPG E D A R L ----- 748
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 735 FEKLR deperwgkpta AV LGA L MAQVDL gag A I - G GKDS M S ------ GSF ED LD V -- P PT LI -- S FA v A V GNMKRATS P E 803
Cdd:PRK05297 749 YDAVK ----------- AV GME L CPALGI --- T I p V GKDS L S mktkwq EGG ED KE V ts P LS LI is A FA - P V EDVRKTLT P Q 813
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 804 FK - GA D HRIVR I -------------- A PR Y -- L A D G l T PD - K DA -- L LEV F SV I EE L TD ------ F HD ala V S TP G YGA T 857
Cdd:PRK05297 814 LR t DK D TALLL I dlgrgknrlggsal A QV Y nq L G D K - A PD v D DA ed L KGF F NA I QA L VA egllla Y HD --- R S DG G LLT T 889
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 858 aea L FK M TLGNRI G VTLN - D SIAV D D --- LF TPAY G sf I V ELADN A KLP AV SN - L V E I G ------ E IG TTTSEYAF -- KA 924
Cdd:PRK05297 890 --- L AE M AFAGHC G LDID l D ALGD D A laa LF NEEL G -- A V IQVRA A DRD AV EA i L A E H G lsdcvh V IG KPNAGDRI vi TR 964
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 925 A G E T L --- DLNAVQEA W E ---------- SGI E SV --- F PYRSKGE D K G KT V E ----- TI D FH AP KK taytg SSV A K P H V V 983
Cdd:PRK05297 965 N G K T V fse SRTELRRW W S etsyqmqrlr DNP E CA dqe F DAILDQA D P G LN V K ltfdp NE D IA AP FI ----- ATG A R P K V A 1039
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 984 I PVFP G N N CEYDS AAAF E RAG A D V ----- TT L I vnnltpaavae STQALV E EINK sq I V MI p GGFS G GD EPD --- G S AK F 1055
Cdd:PRK05297 1040 I LREQ G V N SHVEM AAAF D RAG F D A idvhm SD L L ----------- AGRVTL E DFKG -- L V AC - GGFS Y GD VLG age G W AK S 1105
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 1056 I T af F R apavt EAV RD LLK --- N R - D GLM LG I CNG F Q ALVK L G lvpyg D I V P MTDAC P TLTF N TIGRHQS R LVRTR V ASD 1131
Cdd:PRK05297 1106 I L -- F N ----- PRL RD QFE aff A R p D TFA LG V CNG C Q MMSN L K ----- E I I P GAEHW P RFVR N RSEQFEA R FSLVE V QES 1173
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 1132 L S PW L a KTSV G DIHTV A IS HGEGR FVAS D EV LA Q L K A N G QI A TQ YVD EA G TPGMDLDV NPNGS LLA I E G I T SP DGRV FGK 1211
Cdd:PRK05297 1174 P S IF L - QGMA G SRLPI A VA HGEGR AEFP D AH LA A L E A K G LV A LR YVD NH G QVTETYPA NPNGS PNG I T G L T TA DGRV TIM 1252
....*..
gi 518557708 1212 M G H S ER S 1218
Cdd:PRK05297 1253 M P H P ER V 1259
PLN03206
PLN03206 phosphoribosylformylglycinamidine synthase; Provisional
159-1217
7.46e-51
phosphoribosylformylglycinamidine synthase; Provisional
Pssm-ID: 178745 [Multi-domain]
Cd Length: 1307
Bit Score: 196.91
E-value: 7.46e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 159 VP GK V E T IAGFN E MD A e A GQKFID E R GLA M D LA DL EFCQKY F SEE - G R E PT IT E IKV I DTYW S D H C RH TT F GTE L D evd I 237
Cdd:PLN03206 150 VP EP V Y T VPVME E GR A - A LEEINK E M GLA F D EQ DL DYYTRL F RDD i K R D PT NV E LFD I AQSN S E H S RH WF F SGK L V --- I 225
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 238 D datvkaaferylemrhel G R d AK P VC L MD M GTIGA K WLKK N GILTGL D E S EE I NACT V KVKVD V NG -------- ENQ D W 309
Cdd:PLN03206 226 D ------------------ G Q - PM P KT L FQ M VKDTL K ANPN N SVIGFK D N S SA I RGFV V QPLRP V SP gspsplap VDR D L 286
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 310 LF L FKN ETHN H P TEIE P FG GA A T CI GG C IRD P - LS GR - S Y V YQA -------- M R VT G AAD P TVPV S ETLEGK L -- P QRK L 377
Cdd:PLN03206 287 DI L LTA ETHN F P CAVA P YP GA E T GA GG R IRD T h AT GR g S F V VAG tagycvgn L R IE G SYA P WEDS S FVYPSN L as P LQI L 366
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 378 VT t A AA G Y S S YGN QI G -------------- L AT G QVD E IYH P gyvakr MEVGAVVAATPAD H VRRET P AP G DKIILL GG R 443
Cdd:PLN03206 367 ID - A SN G A S D YGN KF G epliqgytrtfgmr L PN G ERR E WLK P ------ IMFSGGIGQIDHT H LTKGE P DI G MLVVKI GG P 439
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 444 TG R D G I GG ATGA S KAHNVESL ELD GAE VQ K G N A PVER KL Q R LF R rgd AC ------ RL I KRCN D F GAGG VSVA V G E L -- AD 515
Cdd:PLN03206 440 AY R I G M GG GAAS S MVSGQNDA ELD FNA VQ R G D A EMSQ KL Y R VV R --- AC vemged NP I VSIH D Q GAGG NCNV V K E I iy PK 516
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 516 G LFV D LNT V PKKYEG L DGT E LAIS E S QE RM A VDVAA E DV D EFLTYARE E NLEAT VI A T VTEDP R M V M --------- TW NG 586
Cdd:PLN03206 517 G AEI D IRA V VVGDHT L SVL E IWGA E Y QE QD A LLIKP E SR D LLQSICDR E RCSMA VI G T IDGSG R V V L vdsaapekc EA NG 596
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 587 DE ---- I V N L SR E FLASNGAS K HQTVH -- VEAQQGYET P W G E g T LAERMNKMVTDLN V A S NKG L SERF D STIGAGTVLMP 660
Cdd:PLN03206 597 LP pppp A V D L DL E KVLGDMPQ K TFEFK rv ANKLEPLDI P P G I - T VMDALKRVLRLPS V C S KRF L TTKV D RCVTGLVAQQQ 675
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 661 FG G KR Q LT pnmam V A KLP V FGE T --- T T AS A M A W G ------- FN P YI M sknqftg A Y L S V V E S L AK LV A A --- GFEHE KA 727
Cdd:PLN03206 676 TV G PL Q IP ----- L A DVA V IAQ T htg L T GG A C A I G eqpikgl VD P KA M ------- A R L A V G E A L TN LV W A kvt ALSDV KA 743
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 728 YLSFQ e Y FE KL RD E perwgkptaavl GA L M --------- A QVD LG AGAI GGKDS M S ---- GSF E DLDV P PT L - IS FA V AV 793
Cdd:PLN03206 744 SGNWM - Y AA KL DG E ------------ GA D M ydaavalrd A MIE LG VAID GGKDS L S maaq AGG E VVKA P GN L v IS AY V TC 810
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 794 GNMKRATS P EF K GA D HRIV ---------- R IAPRY LA DGL ------ T PD K D --- A L LEV F SVIEE L TDF ------ HD ala 848
Cdd:PLN03206 811 PDITKTVT P DL K LG D DGVL lhvdlgkgkr R LGGSA LA QAY dqigdd C PD L D dva Y L KKA F EATQD L IAK rlisag HD --- 887
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 849 V S TP G YGA T A - E AL F KMTL G NRIGVTLNDSI A VDD LF TPAY G s FIV E LADN ------ A KL P A VS nl V EIGE IG TT T SE -- 919
Cdd:PLN03206 888 I S DG G LVV T L l E MA F AGNC G INVDLPSSGHS A FET LF AEEL G - LVL E VSRK nldavm E KL A A AG -- V TAEV IG QV T AS pl 964
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 920 YAF K AA G E T L --- DLNAVQEA WE sgi E SV F PY rskg E DKGKTVETIDF -------- H AP K - K TAY T GS -------- SVA K 979
Cdd:PLN03206 965 IEV K VD G A T C lse KTASLRDM WE --- E TS F QL ---- E KLQRLESCVAQ ekeglksr K AP T w K LSF T PA ftdkkimn ATS K 1037
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 980 P H V V I PVFP G N N CEYDS AAAF ER AG A --- DVT tli VNN L TPAAVA estqalvee INKSQIVMIP GGFS GG D EP D g SAK FI 1056
Cdd:PLN03206 1038 P K V A I IREE G S N GDREM AAAF YA AG F epw DVT --- MSD L LNGRIS --------- LDDFRGIVFV GGFS YA D VL D - SAK GW 1104
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 1057 TAFF R - APAVTEAVRDLLKNR D GLM LG I CNG F Q ALVK LG L VP YGDIVPMTD A C ----- P TLTF N TI GR HQS R LVRTRVAS 1130
Cdd:PLN03206 1105 AGSI R f NEPLLQQFQEFYNRP D TFS LG V CNG C Q LMAL LG W VP GPQVGGGLG A G gdpsq P RFVH N ES GR FEC R FTSVTIED 1184
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 1131 dl SP - WLA K TSV G DIHT V AIS HGEGR FVAS DE - VL AQLKANGQIATQ Y V D EA G T P GMDLDV NPNGS L L A I EGIT SPDGR V 1208
Cdd:PLN03206 1185 -- SP a IML K GME G STLG V WAA HGEGR AYFP DE s VL DEVLKSNLAPVR Y C D DD G E P TEQYPF NPNGS P L G I AALC SPDGR H 1262
....*....
gi 518557708 1209 FGK M G H S ER 1217
Cdd:PLN03206 1263 LAM M P H P ER 1271
FGAM_synth_I
TIGR01737 phosphoribosylformylglycinamidine synthase I; In some species, ...
982-1241
1.80e-44
phosphoribosylformylglycinamidine synthase I; In some species, phosphoribosylformylglycinamidine synthase is composed of a single polypeptide chain. This model describes the PurQ protein of Bacillus subtilis (where PurL, PurQ, and PurS are required for phosphoribosylformylglycinamidine synthase activity) and functionally equivalent proteins from other bacteria and archaea. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 273782 [Multi-domain]
Cd Length: 227
Bit Score: 161.01
E-value: 1.80e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 982 V VIPV FPG N NC EY D SAA A FERA G A D vttlivnnlt PAA V AESTQA L veei NKSQI V MI PGGFS G GD EPDGS A kf I T A ff R 1061
Cdd:TIGR01737 3 V AVIR FPG T NC DR D TVY A LRLL G V D ---------- AEI V WYEDGS L ---- PDYDG V VL PGGFS Y GD YLRAG A -- I A A -- A 64
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 1062 A P AV t EA VR DLLK nr D G LM - LGICNGFQ A LV KL GL V P ygdivpmtdac PT L TF N TIG R HQS R L V RT RV ASDLSPWLAKTS 1140
Cdd:TIGR01737 65 S P IM - QE VR EFAE -- K G VP v LGICNGFQ I LV EA GL L P ----------- GA L LP N DSL R FIC R W V YL RV ENADTIFTKNYK 130
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 1141 V G DIHTVA I S HGEGR FV A S DE V LA Q L KA N G Q IATQ Y V DE A G T pg MDLDV NPNGS LLA I E GI TSPD G R V F G K M G H S ER SGN 1220
Cdd:TIGR01737 131 K G EVIRIP I A HGEGR YY A D DE T LA R L ES N D Q VVFR Y C DE D G D -- VAEEA NPNGS VGN I A GI VNER G N V L G M M P H P ER ASE 208
250 260
....*....|....*....|.
gi 518557708 1221 G L YVNVP G N K yqp I FE AG VE Y 1241
Cdd:TIGR01737 209 K L LGGDD G L K --- L FE SL VE W 226
PRK03619
PRK03619 phosphoribosylformylglycinamidine synthase subunit PurQ;
983-1217
3.56e-44
phosphoribosylformylglycinamidine synthase subunit PurQ;
Pssm-ID: 235140 [Multi-domain]
Cd Length: 219
Bit Score: 159.51
E-value: 3.56e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 983 VI p VFPG N NC EY D S A A A FER - A GA DVTTLIVNN ltpaavaestqalv EEINKSQI V MI PGGFS G GD epdgsakfita FF R 1061
Cdd:PRK03619 5 VI - VFPG S NC DR D M A R A LRD l L GA EPEYVWHKE -------------- TDLDGVDA V VL PGGFS Y GD ----------- YL R 58
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 1062 AP A ------ VTE AV RDLLK n RDGLM LGICNGFQ A L VKL GL V P y G divpmtdacp T LT F N TIGRHQS R L V RT RV ASDLS P W 1135
Cdd:PRK03619 59 CG A iaafsp IMK AV KEFAE - KGKPV LGICNGFQ I L TEA GL L P - G ---------- A LT R N ASLKFIC R D V HL RV ENNDT P F 126
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 1136 LAKTSV G DIHTVA I S HGEG RFV A SD E V L AQ L KA NGQ IATQ Y V DE agtpgmdldv NPNGS LLA I E GI TSPD G R V F G K M G H S 1215
Cdd:PRK03619 127 TSGYEK G EVIRIP I A HGEG NYY A DE E T L KR L EG NGQ VVFR Y C DE ---------- NPNGS VND I A GI VNEK G N V L G M M P H P 196
..
gi 518557708 1216 ER 1217
Cdd:PRK03619 197 ER 198
PRK14090
PRK14090 phosphoribosylformylglycinamidine synthase subunit PurL;
201-802
5.12e-36
phosphoribosylformylglycinamidine synthase subunit PurL;
Pssm-ID: 184499 [Multi-domain]
Cd Length: 601
Bit Score: 145.77
E-value: 5.12e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 201 SEE GREPT IT E IKVIDTY WS D HC -- R HT tfgteldevdiddatvkaaf ER Y L emrhelgrdakpvclmdmgtiga KW L K K 278
Cdd:PRK14090 9 EKL GREPT FV E LQAFSVM WS E HC gy S HT -------------------- KK Y I ----------------------- RR L P K 45
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 279 N G iltgldes E E I NA CT V KV kvdvnge NQDWLFL FK N E T HNHP TE IEP FG GAAT CI GG C IRD P L sgrsyvyq AM rvtg A A 358
Cdd:PRK14090 46 T G -------- F E G NA GV V NL ------- DDYYSIA FK I E S HNHP SA IEP YN GAAT GV GG I IRD V L -------- AM ---- G A 98
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 359 D PT vpvse TLEGK L PQRKLVTTAAA G YSS YGN Q IG LA T G ---- QVDEI Y HPGYVAKRMEV G A V vaa TPADH V RRETPA PG 434
Cdd:PRK14090 99 R PT ----- AIFDS L HMSRIIDGIIE G IAD YGN S IG VP T V ggel RISSL Y AHNPLVNVLAA G V V --- RNDML V DSKASR PG 170
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 435 DK I ILL GG R TGRDGI G GA TG AS kahnv E S L ELDG A --- EV Q K G NAPV E RK L QRL F RRGDACR L IKRCN D F GAGGV SV A VG 511
Cdd:PRK14090 171 QV I VIF GG A TGRDGI H GA SF AS ----- E D L TGEK A tkl SI Q V G DPFA E KM L IEA F LEMVEEG L VEGAQ D L GAGGV LS A TS 245
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 512 EL AD ---- G LF V D L NT VP KKYEGLDGT E LA ISESQERMAV DVAA E DVDEF L TY A REEN L EATVI A T V TE DP RMVMTWNG D 587
Cdd:PRK14090 246 EL VA kggl G AI V H L DR VP LREPDMEPW E IL ISESQERMAV VTSP E KASRI L EI A KKHL L FGDIV A E V ID DP IYRVMYRD D 325
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 588 EIVNLSREF LA S ng A SKHQT V HVEA qqgyetpwge G TLA E RMNKMVTDL N VAS nkg LS E RF D STI G AG TVL M P - FG GK rq 666
Cdd:PRK14090 326 LVMEVPVQL LA N -- A PEEEI V EYTP ---------- G EIP E FKRVEFEEV N ARE --- VF E QY D HMV G TD TVL P P g FG AA -- 388
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 667 ltpnm A M VA K LPVFGETT T A S AMAWGF npyims KNQFT G AYLS V V ES LA K LVAA G F E h EK A YLSFQE Y feklr DE P ERWG 746
Cdd:PRK14090 389 ----- V M RI K RDGGYSLV T H S RADLAL ------ QDTYW G TFIA V L ES VR K TLSV G A E - PL A ITNCVN Y ----- GD P DVDP 451
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*..
gi 518557708 747 KPTA A VLG AL MAQVDL - G AGAIG G KD S MSGSFEDLDV PPTL ISFAVAVG N MKRATS P 802
Cdd:PRK14090 452 VGLS A MMT AL KDACEF s G VPVAS G NA S LYNTYQGKPI PPTL VVGMLGKV N PQKVAK P 508
PRK01175
PRK01175 phosphoribosylformylglycinamidine synthase I; Provisional
980-1217
3.40e-32
phosphoribosylformylglycinamidine synthase I; Provisional
Pssm-ID: 234913 [Multi-domain]
Cd Length: 261
Bit Score: 126.80
E-value: 3.40e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 980 PH V VIPVFP G N NCE YDSAA AF E R A G ADVTTLIV N N L tpaavaest Q A LVEEINKSQIVM IPGGFS G GD EPDGS A K F i T A F 1059
Cdd:PRK01175 4 IR V AVLRME G T NCE DETVK AF R R L G VEPEYVHI N D L --------- A A ERKSVSDYDCLV IPGGFS A GD YIRAG A I F - A A R 73
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 1060 FR A PAVTE a VRDLLK nr D G - LML GICNGFQ A LV K LGL V P YG D IVPMTDAC p T LT F N TIG R HQS R LVRTRVASD l SPWLA K 1138
Cdd:PRK01175 74 LK A VLRKD - IEEFID -- E G y PII GICNGFQ V LV E LGL L P GF D EIAEKPEM - A LT V N ESN R FEC R PTYLKKENR - KCIFT K 148
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 1139 TSVG D IHT V AIS H G EGR F V A S D - E V L AQ L KA N G QI ATQ YVDE ---- AG T P G mdldv NPNGS LLA I E GIT SPD G R V F G K M G 1213
Cdd:PRK01175 149 LLKK D VFQ V PVA H A EGR V V F S E e E I L ER L IE N D QI VFR YVDE ngny AG Y P W ----- NPNGS IYN I A GIT NEK G N V I G L M P 223
....
gi 518557708 1214 H S ER 1217
Cdd:PRK01175 224 H P ER 227
PurL
cd02193 Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent ...
312-574
6.29e-31
Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100029 [Multi-domain]
Cd Length: 272
Bit Score: 123.18
E-value: 6.29e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 312 LF K N E T HNHP TE I E P FG GAAT CI GG C IRD PLS - G RS yvyq A MRVTGA A DPTVP vsetl E G KLPQRKLVTT A AA G YSSYG N 390
Cdd:cd02193 4 AM K I E E HNHP AA I D P AA GAAT GV GG A IRD IAA t G ID ---- A KPIALS A NWMAS ----- A G HPGEDAILYD A VK G VAELC N 74
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 391 Q I GL AT ---------------- GQVD E IY HP gyva KRMEVG A VVAATPAD H VRRETPAP G DKII L L GG RT G RD G I GG ATG 454
Cdd:cd02193 75 Q L GL PI pvgkdrmsmktrwqeg NEQR E MT HP ---- PSLVIS A FGRVRDDR H TLPQLSTE G NALL L I GG GK G HN G L GG TAL 150
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 455 AS K A HNVE sl E L DGAEV Q KGNAPV E RKLQRLFRRGD A CRLIKRCN D F GAGG VS VA VG EL AD ---- G LF VDL NTVPKKYEG 530
Cdd:cd02193 151 AS V A LSYR -- Q L GDKSA Q VRDPAQ E KGFYEAMQALV A AGKLLAWH D R GAGG LL VA LA EL VF aghc G VQ VDL AALGDDEPD 228
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 518557708 531 LDGT E L A IS ESQER MAVD V A AED V D EFLTYAREENLEAT V IATV 574
Cdd:cd02193 229 MEPL E I A LF ESQER GVIQ V R AED R D AVEEAQYGLADCVH V LGQA 272
AIRS_C
pfam02769 AIR synthase related protein, C-terminal domain; This family includes Hydrogen expression ...
433-584
6.64e-26
AIR synthase related protein, C-terminal domain; This family includes Hydrogen expression/formation protein HypE, AIR synthases EC:6.3.3.1, FGAM synthase EC:6.3.5.3 and selenide, water dikinase EC:2.7.9.3. The function of the C-terminal domain of AIR synthase is unclear, but the cleft formed between N and C domains is postulated as a sulphate binding site.
Pssm-ID: 460684 [Multi-domain]
Cd Length: 152
Bit Score: 104.74
E-value: 6.64e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 433 PGD KI ILLG G rtgr D G IG GA TGASKAHNV E SLE L DG ae VQ K G NAPV E RK L QRLFRRGD A CR - L I K RCN D FGA GG VSV A VG 511
Cdd:pfam02769 2 PGD VL ILLG S ---- S G LH GA GLSLSRKGL E DSG L AA -- VQ L G DPLL E PT L IYVKLLLA A LG g L V K AMH D ITG GG LAG A LA 75
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518557708 512 E L A D ---- G LFV DL NT VP KKY E GLDGT E LAI SE S Q E R MA V D VA A E DVDEF L TYARE E N LEA T VI AT VT EDP R MVMTW 584
Cdd:pfam02769 76 E M A P asgv G AEI DL DK VP IFE E LMLPL E MLL SE N Q G R GL V V VA P E EAEAV L AILEK E G LEA A VI GE VT AGG R LTVIV 152
PHA03366
PHA03366 FGAM-synthase; Provisional
678-1207
8.07e-12
FGAM-synthase; Provisional
Pssm-ID: 223058 [Multi-domain]
Cd Length: 1304
Bit Score: 70.05
E-value: 8.07e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 678 P V FGETTTASAM A W G FNP Y IMSKNQFT GA YLSV VE S L AK L VA A GFEH - E K ---- AYLSFQE yfeklrdeperw GKPT A AV 752
Cdd:PHA03366 682 S V LHPAVPGTCS A L G EQG Y KVQLDPIL GA KYAI VE A L TN L ML A PVAN l E D itit LSVTWPP ------------ TDQA A SE 749
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 753 L GALM A QV ----- D LG AGAIGGKD S M S GSFEDLDV P PT L ISFA V AVGN ------ MK R A T s P EF K GADHRI -- VR I A P R Y L 819
Cdd:PHA03366 750 L YRAL A AC kefcr E LG VNFTFTSA S S S PRQDQPPQ P GP L FNTI V FTAS apvpss TP R L T - P DL K KPGSAL vh LS I S P E Y T 828
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 820 AD G -------------- LTPDKDA L LEV F SVIEE L td FHDA L A VS tp G Y ---- G ATAEA L FK M T L - G N R i GVT LN --- DS 877
Cdd:PHA03366 829 LA G svfeqifglksgtl PDISPSY L KNL F RAVQH L -- ISEG L V VS -- G H dvsd G GLIAC L AE M A L a G G R - GVT IT vpa GE 903
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 878 IAVDD LF TPAY G s FIV E L a DNAK L P AV ------ S N LV -- E IG EI G TTTSEYA F -- KAA G ET L --- D L NAVQEA W E S GIES 944
Cdd:PHA03366 904 DPLQF LF SETP G - VVI E V - PPSH L S AV ltrlrs R N II cy P IG TV G PSGPSNT F sv SHN G TV L fre S L SSLRST W R S FSDE 981
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 945 V F PYRSKGEDKGKTVET ------ I D FHAPK ------- KTA YT GSS va K P H - V VIPVF PG NNCEYDSA AAF ER AG A D VTTL 1010
Cdd:PHA03366 982 Q F ELLRPDLTEESMYRK dygnne V D LGPLE eglttsp LRL YT CPD -- K R H r V AVLLL PG CPGPHALL AAF TN AG F D PYPV 1059
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 1011 ivnnltpaavaestqa LV EE INKSQIV ----- MIP GG F SG GDEPDGS A K - FIT A FFRA PAV TE A VRDL L KNR D GLM LG IC 1084
Cdd:PHA03366 1060 ---------------- SI EE LKDGTFL defsg LVI GG S SG AEDSYTG A R a AVA A LLSN PAV RD A LLRF L NRP D TFS LG CG 1123
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 1085 N - G F Q A L VK L GL V ------ P YGDIVPMTDACP TL TF N TI G RHQ SR LVRTRVASD ----- L S P -------- W LAK T SV G di 1144
Cdd:PHA03366 1124 E l G C Q I L FA L KA V gstaps P VPGTETEEQWPI TL EP N AS G LYE SR WLNFYIPET tksva L R P lrgsvlpc W AQG T HL G -- 1201
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518557708 1145 htva ISH gegrfv AS D EVLAQ L KAN GQIA TQYVDEAGT PG --- MDLDV NP N G S l LAIE G IT S P DGR 1207
Cdd:PHA03366 1202 ---- FRY ------ PN D GMEYI L RNS GQIA ATFHGADVD PG npa RHYPR NP T G N - SNVA G LC S A DGR 1256
PurM-like
cd00396 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen ...
312-573
6.47e-10
AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain of AIR synthase forms the dimer interface of the protein, and is suggested as a putative ATP binding domain.
Pssm-ID: 100027 [Multi-domain]
Cd Length: 222
Bit Score: 60.49
E-value: 6.47e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 312 LFKNETH N H P TE I E P FG G AATCI GG CIR D PL sgrsy VYQ A MRVTGA A DPTVPVSETLEG klpqrkl VTTAAA G YSSYG NQ 391
Cdd:cd00396 3 AMSTDGI N P P LA I N P WA G GRLAV GG AVN D IA ----- AMG A RPIALL A SLSLSNGLEVDI ------- LEDVVD G VAEAC NQ 70
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 392 I G LATGQVDEIYH PG YVAKRMEVGAVVAA - TPA D H V RRETP A - PGD KI IL lggr TG R D GIGGATG A SKA H NVE sleldga 469
Cdd:cd00396 71 L G VPIVGGHTSVS PG TMGHKLSLAVFAIG v VEK D R V IDSSG A r PGD VL IL ---- TG V D AVLELVA A GDV H AMH ------- 139
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 470 evqkgnapverklqrlfrrgdacrlikrcn D FGA GG VSVAVG ELA D ---- G LFV DL NTV P ----- KKYEGLDGT E LAISE 540
Cdd:cd00396 140 ------------------------------ D ITD GG LLGTLP ELA Q asgv G AEI DL EAI P ldevv RWLCVEHIE E ALLFN 189
250 260 270
....*....|....*....|....*....|...
gi 518557708 541 S QERMAVD V A AE DV D EF L TYAREENLE A T VI AT 573
Cdd:cd00396 190 S SGGLLIA V P AE EA D AV L LLLNGNGID A A VI GR 222
FGAR-AT_linker
pfam18072 Formylglycinamide ribonucleotide amidotransferase linker domain; This is the linker domain ...
183-225
4.39e-09
Formylglycinamide ribonucleotide amidotransferase linker domain; This is the linker domain found in Formylglycinamide ribonucleotide amidotransferase (FGAR-AT), also known as Phosphoribosylformylglycinamidine synthase (EC:6.3.5.3), PurL and formylglycinamidine ribonucleotide (FGAM) synthase. This enzyme catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, Pi, and glutamate in the fourth step of the purine biosynthetic pathway. The structure analysis of Salmonella typhimurium FGAR-AT reveals that this linker domain is made up of a long hydrophilic belt with an extended conformation.
Pssm-ID: 465632 [Multi-domain]
Cd Length: 50
Bit Score: 53.24
E-value: 4.39e-09
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 518557708 183 ER GLA MDLADLEFCQK YF SEE GR E PT IT E IKVIDTY WS D HCRH 225
Cdd:pfam18072 7 YL GLA LSDDEIDYLVE YF AGL GR N PT DV E LGMFAQM WS E HCRH 49
GATase1
cd01653 Type 1 glutamine amidotransferase (GATase1)-like domain; Type 1 glutamine amidotransferase ...
982-1091
4.85e-06
Type 1 glutamine amidotransferase (GATase1)-like domain; Type 1 glutamine amidotransferase (GATase1)-like domain. This group includes proteins similar to Class I glutamine amidotransferases, the intracellular PH1704 from Pyrococcus horikoshii, the C-terminal of the large catalase: Escherichia coli HP-II, Sinorhizobium meliloti Rm1021 ThuA. and, the A4 beta-galactosidase middle domain. The majority of proteins in this group have a reactive Cys found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow. For Class I glutamine amidotransferases proteins which transfer ammonia from the amide side chain of glutamine to an acceptor substrate, this Cys forms a Cys-His-Glu catalytic triad in the active site. Glutamine amidotransferases activity can be found in a range of biosynthetic enzymes included in this cd: glutamine amidotransferase, formylglycinamide ribonucleotide, GMP synthetase, anthranilate synthase component II, glutamine-dependent carbamoyl phosphate synthase, cytidine triphosphate synthetase, gamma-glutamyl hydrolase, imidazole glycerol phosphate synthase and, cobyric acid synthase. For Pyrococcus horikoshii PH1704, the Cys of the nucleophile elbow together with a different His and, a Glu from an adjacent monomer form a catalytic triad different from the typical GATase1 triad. The E. coli HP-II C-terminal domain, S. meliloti Rm1021 ThuA and the A4 beta-galactosidase middle domain lack the catalytic triad typical GATaseI domains. GATase1-like domains can occur either as single polypeptides, as in Class I glutamine amidotransferases, or as domains in a much larger multifunctional synthase protein, such as CPSase.
Pssm-ID: 153210 [Multi-domain]
Cd Length: 115
Bit Score: 46.82
E-value: 4.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 982 V VIPV FPG NNCE -- YDSAA A FER AGA D V TTL ivnnltpa AVAESTQALVEEINKSQIVMI PGG FSGG D epdgsakfit AF 1059
Cdd:cd01653 1 V AVLL FPG FEEL el ASPLD A LRE AGA E V DVV -------- SPDGGPVESDVDLDDYDGLIL PGG PGTP D ---------- DL 62
90 100 110
....*....|....*....|....*....|..
gi 518557708 1060 F R AP A VTEAV R DLLK n RDGLM LGIC N G F Q A LV 1091
Cdd:cd01653 63 A R DE A LLALL R EAAA - AGKPI LGIC L G A Q L LV 93
PurL_repeat2
cd02204 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. ...
417-574
1.94e-05
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100035 [Multi-domain]
Cd Length: 264
Bit Score: 47.92
E-value: 1.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 417 VV A ATPA D H VR R ---- ETPAP GD KII L L G gr TGR D GI GG ATG A SKA H NVE sleld G AEVQKGNAPV E RK L QRLFRRGDAC 492
Cdd:cd02204 114 IG A VGVV D D VR K ivtl DFKKE GD LLY L I G -- ETK D EL GG SEY A LAY H GLG ----- G GAPPLVDLER E KA L FDAVQELIKE 186
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 493 R L IKRCN D FGA GG VS VA VG E L A D ---- G LF VDL NTVPKK yegldg T EL AI SES QE R MA V D V AA E DVDE F L ty A R E ENLE A 568
Cdd:cd02204 187 G L VLSAH D VSD GG LA VA LA E M A F aggl G AE VDL SKDDAE ------ D EL LF SES LG R VL V E V KP E NEEV F E -- A E E AGVP A 258
....*.
gi 518557708 569 TVI A TV 574
Cdd:cd02204 259 TVI G TV 264
GAT_1
cd03128 Type 1 glutamine amidotransferase (GATase1)-like domain; Type 1 glutamine amidotransferase ...
982-1090
3.53e-05
Type 1 glutamine amidotransferase (GATase1)-like domain; Type 1 glutamine amidotransferase (GATase1)-like domain. This group contains proteins similar to Class I glutamine amidotransferases, the intracellular PH1704 from Pyrococcus horikoshii, the C-terminal of the large catalase: Escherichia coli HP-II, Sinorhizobium meliloti Rm1021 ThuA, the A4 beta-galactosidase middle domain and peptidase E. The majority of proteins in this group have a reactive Cys found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow. For Class I glutamine amidotransferases proteins which transfer ammonia from the amide side chain of glutamine to an acceptor substrate, this Cys forms a Cys-His-Glu catalytic triad in the active site. Glutamine amidotransferases activity can be found in a range of biosynthetic enzymes included in this cd: glutamine amidotransferase, formylglycinamide ribonucleotide, GMP synthetase, anthranilate synthase component II, glutamine-dependent carbamoyl phosphate synthase (CPSase), cytidine triphosphate synthetase, gamma-glutamyl hydrolase, imidazole glycerol phosphate synthase and, cobyric acid synthase. For Pyrococcus horikoshii PH1704, the Cys of the nucleophile elbow together with a different His and, a Glu from an adjacent monomer form a catalytic triad different from the typical GATase1 triad. Peptidase E is believed to be a serine peptidase having a Ser-His-Glu catalytic triad which differs from the Cys-His-Glu catalytic triad of typical GATase1 domains, by having a Ser in place of the reactive Cys at the nucleophile elbow. The E. coli HP-II C-terminal domain, S. meliloti Rm1021 ThuA and the A4 beta-galactosidase middle domain lack the catalytic triad typical GATaseI domains. GATase1-like domains can occur either as single polypeptides, as in Class I glutamine amidotransferases, or as domains in a much larger multifunctional synthase protein, such as CPSase. Peptidase E has a circular permutation in the common core of a typical GTAse1 domain.
Pssm-ID: 153222 [Multi-domain]
Cd Length: 92
Bit Score: 43.73
E-value: 3.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518557708 982 V VIPV F P G NNCEYDS -- AA A FER AGA D V TTL ivnnltpa AVAESTQALVEEINKSQIVMI PGG FSGG D epdgsakfit AF 1059
Cdd:cd03128 1 V AVLL F G G SEELELA sp LD A LRE AGA E V DVV -------- SPDGGPVESDVDLDDYDGLIL PGG PGTP D ---------- DL 62
90 100 110
....*....|....*....|....*....|.
gi 518557708 1060 FRAP A VTEAV R DLLK n RDGLM LGIC N G F Q A L 1090
Cdd:cd03128 63 AWDE A LLALL R EAAA - AGKPV LGIC L G A Q L L 92
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
