|
Name |
Accession |
Description |
Interval |
E-value |
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
6-600 |
0e+00 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 1020.07 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 6 FFRSIQFKITLIYVLLIIIAMQIIGVYFVNQVEKSLISSYEQSLNQRIDNLSYYIEQEY-KSDNDSTVIKDDVSRILNDF 84
Cdd:NF033092 1 FFRSIHFKIVLIYVLLILIAMQIIGVYFVRQLETQLLNNFKESINLRANLLSYNLEQELsKEDEDDETLEEDIRTILNDF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 85 TkSDEVREISFVDKSYEVVGSSKPYGEEVAGKQTTDLIFKRIFSTKQSYLRKYYDPKSKIRVLISAKPVMTENQEVVGAI 164
Cdd:NF033092 81 N-NNDISEIQVIDAKGTILGTSDPSNQSIVGQKTTDSDVKRALLGGKDNEKILIDPEDNNRVYVLATPIKSSNGEVVGAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 165 YVVASMEDVFNQMKTINTILASGTGLALVLTALLGIFLARTITHPLSDMRKQAMELAKGNFSRKVKKYGHDEIGQLATTF 244
Cdd:NF033092 160 YIEASMESVYDQMNNINLIFATGTLIALVITAVLGILLARTITRPIKEMRKQALAMAKGDFSRKVKVYGNDEIGQLAEAF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 245 NHLTRELEDAQAMTEGERRKLASVIAYMTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLGIQENYTFEDLV 324
Cdd:NF033092 240 NNLTKRLQEAQATTESERRKLDSVLSHMTDGVIATDRRGRVILINDPALEMLNVSRETVLGQSILDVLGLEEEYTLRDLL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 325 EQQDSMLLEIERDDELTVLRVNFSVIQREHGKIDGLIAVIYDVTEQEKMDQERREFVANVSHELRTPLTTMRSYLEALAE 404
Cdd:NF033092 320 EEQDSLLLDFSTEEEPLILRANFSVIQRESGFINGLIAVLHDVTEQEKIEQERREFVANVSHELRTPLTTMRSYLEALAD 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 405 GAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNREWIQIVRFISLIIDRFEM-TKEQHVEFIRNLPDRN 483
Cdd:NF033092 400 GAWKDPELAPRFLGVTQNETERMIRLVNDLLQLSRMDSKDYKLNKEWVNFNEFFNYIIDRFEMiLKNKNITFKREFPKRD 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 484 LYVEIDQDKITQVLDNIISNALKYSPEGGHVTFSIDvnEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGG 563
Cdd:NF033092 480 LWVEIDTDKITQVLDNIISNAIKYSPEGGTITFRLL--ETHNRIIISISDQGLGIPKKDLDKIFDRFYRVDKARSRKMGG 557
|
570 580 590
....*....|....*....|....*....|....*..
gi 518546137 564 TGLGLAIAREMVQAHGGDIWADSIEGKGTTITFTLPY 600
Cdd:NF033092 558 TGLGLAIAKEVVEAHGGRIWAESEEGKGTTIYFTLPY 594
|
|
| HK_VicK |
NF033093 |
cell wall metabolism sensor histidine kinase VicK; This model describes the protein VicK (or ... |
170-610 |
2.97e-135 |
|
cell wall metabolism sensor histidine kinase VicK; This model describes the protein VicK (or WalK) as found in Streptococcus pneumoniae, This protein is shorter than the WalK of Staphylococcus aureus, although apparently is functionally similar. Compare to model NF033092 (HK_WalK). VicK is a sensor histidine kinase involved in regulating cell wall metabolism. Its two component system partner is the response regulatory VicR.
Pssm-ID: 467965 [Multi-domain] Cd Length: 448 Bit Score: 402.56 E-value: 2.97e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 170 MEDVFNQMKTINTILAsgtgLALVLTALLGIFLA---RTITHPLSDMRKQAMELAKGNFSRKVKKYGHDEIGQLATTFNH 246
Cdd:NF033093 2 IDNIKQNIFSFEFAFL----LLLLGFILYFILLAlrnRRDNKQLRQLNQKVKDLIAGDYSEVLDMQGDPELTELTNSLND 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 247 LTRELEDAQAMTEGERRKLASVIAYMTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLGIQENYTFEDLVEQ 326
Cdd:NF033093 78 LSEVFRLTHENLEQEKNRLASILSYMTDGVLATNRRGQIIMINDTAQKQLNVKREEALNMNILDLLDIDDEYDLRDLITK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 327 QDSMLLEIERD-DELTVLRVNFSVIQREHGKIDGLIAVIYDVTEQEKMDQERREFVANVSHELRTPLTTMRSYLEALAEG 405
Cdd:NF033093 158 TPELTLDSRDEnGEFLSLRVRFALIRRESGFISGLVAVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 406 AWeNKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNREWIQIVRFISLIIDRFEMTKEQH------VEFIRNL 479
Cdd:NF033093 238 AL-SEPVAPSFIKVSLDETNRMMRMISDLLSLSRIDNQTSHLDVELTNFTAFITFILNRFDQIKSQDtetgkkYEIVRDY 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 480 PDRNLYVEIDQDKITQVLDNIISNALKYSPEGGHVTFSIDVNEEEelLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTR 559
Cdd:NF033093 317 PITSIWVEIDTDKMTQVIDNILNNAIKYSPDGGKITVSMKTTDTQ--LIISISDEGLGIPKKDLPLIFDRFYRVDKARSR 394
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 518546137 560 KLGGTGLGLAIAREMVQAHGGDIWADSIEGKGTTITFTLPYKEE--QEDDWDE 610
Cdd:NF033093 395 AQGGTGLGLAIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDavKDDEWED 447
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
285-603 |
5.07e-107 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 327.66 E-value: 5.07e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 285 IILLNSPALELLNVSRETALEMPITSLLGIQENYTFEDLVEQQDSMLLEIERDDELTVLRVNFSVIQREHGKIDGLIAVI 364
Cdd:COG5002 73 LLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVE 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 365 YDVTEQEKMDQERREFVANVSHELRTPLTTMRSYLEALAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKD 444
Cdd:COG5002 153 RDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGE 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 445 YQFNREWIQIVRFISLIIDRFEMT-KEQHVEFIRNLPDRNLYVEIDQDKITQVLDNIISNALKYSPEGGHVTFSIDvnEE 523
Cdd:COG5002 233 LKLEKEPVDLAELLEEVVEELRPLaEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLR--EE 310
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 524 EELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGLGLAIAREMVQAHGGDIWADSIEGKGTTITFTLPYKEE 603
Cdd:COG5002 311 DDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLARE 390
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
183-605 |
3.15e-87 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 277.61 E-value: 3.15e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 183 ILASGTGLALVLTALLGIFLARTITHPLSDMRKQAMELAKGNFSRKVKKYGHDEIGQLATTFNHLTRELEDAQAMTEGER 262
Cdd:COG5000 10 LLLLIALLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKEQREELEERR 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 263 RKLASVIAYMTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLGIQENY-TFEDLVEQQDSMLLEIERDDELT 341
Cdd:COG5000 90 RYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGKPLEELLPELDLAeLLREALERGWQEEIELTRDGRRT 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 342 VLrvnfsvIQREHGKIDGLIAVIYDVTEQEKmdQER----REFVANVSHELRTPLTTMRSYLE----ALAEGAWENKDIA 413
Cdd:COG5000 170 LL------VRASPLRDDGYVIVFDDITELLR--AERlaawGELARRIAHEIKNPLTPIQLSAErlrrKLADKLEEDREDL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 414 PRFLMVTQNETERMIRLVNDLLQLSKFDskdyQFNREWIQIVRFISLIIDRFEMT-KEQHVEFIRNLPDRNLYVEIDQDK 492
Cdd:COG5000 242 ERALDTIIRQVDRLKRIVDEFLDFARLP----EPQLEPVDLNELLREVLALYEPAlKEKDIRLELDLDPDLPEVLADRDQ 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 493 ITQVLDNIISNALKYSPEGGHVTFSIDVNEEEelLYISVKDEGIGIPKKDVEKVFDRFYrvdkarTRKLGGTGLGLAIAR 572
Cdd:COG5000 318 LEQVLINLLKNAIEAIEEGGEIEVSTRREDGR--VRIEVSDNGPGIPEEVLERIFEPFF------TTKPKGTGLGLAIVK 389
|
410 420 430
....*....|....*....|....*....|...
gi 518546137 573 EMVQAHGGDIWADSIEGKGTTITFTLPYKEEQE 605
Cdd:COG5000 390 KIVEEHGGTIELESRPGGGTTFTIRLPLAEEAE 422
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
369-603 |
3.66e-83 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 260.61 E-value: 3.66e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 369 EQEKMDQERREFVANVSHELRTPLTTMRSYLEALAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFN 448
Cdd:COG2205 8 ELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLESGKLSLE 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 449 REWIQIVRFISLIIDRFEMT-KEQHVEFIRNLPDRNLYVEIDQDKITQVLDNIISNALKYSPEGGHVTfsIDVNEEEELL 527
Cdd:COG2205 88 LEPVDLAELLEEAVEELRPLaEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTIT--ISARREGDGV 165
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518546137 528 YISVKDEGIGIPKKDVEKVFDRFYRVDkaRTRKLGGTGLGLAIAREMVQAHGGDIWADSIEGKGTTITFTLPYKEE 603
Cdd:COG2205 166 RISVSDNGPGIPEEELERIFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAES 239
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
268-599 |
2.39e-75 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 243.66 E-value: 2.39e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 268 VIAYMTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLGIQENYTFEDLVEQQDSMLLEIERDDELTVLRVNF 347
Cdd:COG0642 1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 348 SVIQREHGKIDGLIAVIYDVTEQEKMDQERREFVANVSHELRTPLTTMRSYLEALAEGAWENkdiAPRFLMVTQNETERM 427
Cdd:COG0642 81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEE---QREYLETILRSADRL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 428 IRLVNDLLQLSKFDSKDYQFNREWIQIVRFISLIIDRFE-MTKEQHVEFIRNLPDRNLYVEIDQDKITQVLDNIISNALK 506
Cdd:COG0642 158 LRLINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRpLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIK 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 507 YSPEGGHVTfsIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRklGGTGLGLAIAREMVQAHGGDIWADS 586
Cdd:COG0642 238 YTPEGGTVT--VSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRG--GGTGLGLAIVKRIVELHGGTIEVES 313
|
330
....*....|...
gi 518546137 587 IEGKGTTITFTLP 599
Cdd:COG0642 314 EPGKGTTFTVTLP 326
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
259-598 |
1.35e-72 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 236.34 E-value: 1.35e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 259 EGERRKLASVIAYMTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLGIQEnytFEDLVEQQDS---MLLEIE 335
Cdd:TIGR02966 2 SALLSRFRAAAQALPDAVVVLDEEGQIEWCNPAAERLLGLRWPDDLGQRITNLIRHPE---FVEYLAAGRFsepLELPSP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 336 RDDELTVlrvnfsVIQREHGKIDGLIAVIYDVTEQEKMDQERREFVANVSHELRTPLTTMRSYLEALAEGAWENKDIAPR 415
Cdd:TIGR02966 79 INSERVL------EIRIAPYGEEQKLLVARDVTRLRRLEQMRRDFVANVSHELRTPLTVLRGYLETLADGPDEDPEEWNR 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 416 FLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNREWIQIVRFISLIIDRFEMT---KEQHVEFIrnlPDRNLYVEIDQDK 492
Cdd:TIGR02966 153 ALEIMLEQSQRMQSLVEDLLTLSRLESAASPLEDEPVDMPALLDHLRDEAEALsqgKNHQITFE---IDGGVDVLGDEDE 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 493 ITQVLDNIISNALKYSPEGGHVTfsIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGLGLAIAR 572
Cdd:TIGR02966 230 LRSAFSNLVSNAIKYTPEGGTIT--VRWRRDGGGAEFSVTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVK 307
|
330 340
....*....|....*....|....*.
gi 518546137 573 EMVQAHGGDIWADSIEGKGTTITFTL 598
Cdd:TIGR02966 308 HVLSRHHARLEIESELGKGSTFSFIF 333
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
256-607 |
5.92e-63 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 212.01 E-value: 5.92e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 256 AMTEGERRkLASVIAYMTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLgiQENYTFEDLVEQ-----QDSM 330
Cdd:COG3852 1 ALRESEEL-LRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELF--PEDSPLRELLERalaegQPVT 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 331 LLEIE---RDDELTVLRVNFSVIQREHGKiDGLIAVIYDVTEQEKMDQERR---------EFVANVSHELRTPLTTMRSY 398
Cdd:COG3852 78 EREVTlrrKDGEERPVDVSVSPLRDAEGE-GGVLLVLRDITERKRLERELRraeklaavgELAAGLAHEIRNPLTGIRGA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 399 LEALAEGAWENKDiaPRFLMVTQNETERMIRLVNDLLQLSKFDskdyQFNREWIQIVRFISLIIDRFEMTKEQHVEFIRN 478
Cdd:COG3852 157 AQLLERELPDDEL--REYTQLIIEEADRLNNLVDRLLSFSRPR----PPEREPVNLHEVLERVLELLRAEAPKNIRIVRD 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 479 LPDRNLYVEIDQDKITQVLDNIISNALKYSPEGGHVTFSIDVNEEEEL--------LYISVKDEGIGIPKKDVEKVFDRF 550
Cdd:COG3852 231 YDPSLPEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVERQVTLgglrprlyVRIEVIDNGPGIPEEILDRIFEPF 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 518546137 551 YrvdkarTRKLGGTGLGLAIAREMVQAHGGDIWADSIEGKGTTITFTLPYKEEQEDD 607
Cdd:COG3852 311 F------TTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQAEEEP 361
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
157-603 |
1.36e-58 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 206.74 E-value: 1.36e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 157 NQEVVGAIYVVASMEDVFNQMKTINTILASGTGLALVLTALLGIFLARTITHPLSDMRKQAMELAKgNFSRKVKKYgHDE 236
Cdd:PRK11360 165 NGEVIGYIWANELTEDIRRQAWKMDRRIYAVLAAGLVIGLLLIFLLSRRFSANVDIIKDGLSTLEN-DLSTRLPPL-PGE 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 237 IGQLATTFNHLTRELEDAQAMTEgerrklaSVIAYMTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLGIQE 316
Cdd:PRK11360 243 LGEISQAINNLAQALRETRSLNE-------LILESIADGVIAIDRQGKITTMNPAAEVITGLQRHELVGKPYSELFPPNT 315
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 317 ---NYTFEDLVEQQDSMLLEIE---RDDELTVLrVNFSVIQREHGKIDGLIAVIYDVTE----QEKMDQERR-----EFV 381
Cdd:PRK11360 316 pfaSPLLDTLEHGTEHVDLEISfpgRDRTIELS-VSTSLLHNTHGEMIGALVIFSDLTErkrlQRRVARQERlaalgELV 394
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 382 ANVSHELRTPLTTMRSYLEALAEGAweNKDIAPRFLMVTQNETERMIRLVNDLLQLSKFdskdyqfNREWIQIVRFISLI 461
Cdd:PRK11360 395 AGVAHEIRNPLTAIRGYVQIWRQQT--SDPPSQEYLSVVLREVDRLNKVIDQLLEFSRP-------RESQWQPVSLNALV 465
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 462 IDRFEMTKEQH----VEFIRNLpDRNL-YVEIDQDKITQVLDNIISNALKYSPEGGHVTFSIDVNEEEELlYISVKDEGI 536
Cdd:PRK11360 466 EEVLQLFQTAGvqarVDFETEL-DNELpPIWADPELLKQVLLNILINAVQAISARGKIRIRTWQYSDGQV-AVSIEDNGC 543
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518546137 537 GIPKKDVEKVFDRFYrvdkarTRKLGGTGLGLAIAREMVQAHGGDIWADSIEGKGTTITFTLPYKEE 603
Cdd:PRK11360 544 GIDPELLKKIFDPFF------TTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINPQ 604
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
262-601 |
8.45e-49 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 177.09 E-value: 8.45e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 262 RRKLASVIAYMTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLGIQENYTFEDLVEQ--QDSMLLEIE---- 335
Cdd:COG5809 140 EEKFRLIFNHSPDGIIVTDLDGRIIYANPAACKLLGISIEELIGKSILELIHSDDQENVAAFISQllKDGGIAQGEvrfw 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 336 -RDDELTVLRVNFSVIQREhGKIDGLIAVIYDVTEQEKMDQERR---------EFVANVSHELRTPLTTMRSYLEALAEG 405
Cdd:COG5809 220 tKDGRWRLLEASGAPIKKN-GEVDGIVIIFRDITERKKLEELLRkseklsvvgELAAGIAHEIRNPLTSLKGFIQLLKDT 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 406 AWENKDiapRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFnrewIQIVRFISLIIDRFE----MTKEQ-HVEFIRNLP 480
Cdd:COG5809 299 IDEEQK---TYLDIMLSELDRIESIISEFLVLAKPQAIKYEP----KDLNTLIEEVIPLLQpqalLKNVQiELELEDDIP 371
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 481 DrnlyVEIDQDKITQVLDNIISNALKYSPEGGHVTFSIdVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYrvdkarTRK 560
Cdd:COG5809 372 D----ILGDENQLKQVFINLLKNAIEAMPEGGNITIET-KAEDDDKVVISVTDEGCGIPEERLKKLGEPFY------TTK 440
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 518546137 561 LGGTGLGLAIAREMVQAHGGDIWADSIEGKGTTITFTLPYK 601
Cdd:COG5809 441 EKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIK 481
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
235-599 |
1.74e-48 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 176.90 E-value: 1.74e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 235 DEIGQLATTFNHLTRELEDAQAMTEGERRKLASVIAYMTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLGI 314
Cdd:COG4251 136 LLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEA 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 315 QENYTFEDLVEQQDSMLLEIERDDELTVLRVNFSVIQREHGKIDGLIAVIYDVTEQ----EKMDQERREFVANVSHELRT 390
Cdd:COG4251 216 ELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERtaelERSNEELEQFAYVASHDLRE 295
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 391 PLTTMRSYLEALAEGAWENKD-IAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFnrEWIQIVRFISLIIDRFEMT- 468
Cdd:COG4251 296 PLRKISGFSQLLEEDYGDKLDeEGREYLERIRDAAERMQALIDDLLAYSRVGRQELEF--EPVDLNELLEEVLEDLEPRi 373
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 469 KEQHVEF-IRNLPDrnlyVEIDQDKITQVLDNIISNALKYSPEGGHVTFSIDVNEEEELLYISVKDEGIGIPKKDVEKVF 547
Cdd:COG4251 374 EERGAEIeVGPLPT----VRGDPTLLRQVFQNLISNAIKYSRPGEPPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIF 449
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 518546137 548 DRFYRVDkaRTRKLGGTGLGLAIAREMVQAHGGDIWADSIEGKGTTITFTLP 599
Cdd:COG4251 450 EIFQRLH--SRDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLP 499
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
8-599 |
6.25e-46 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 169.82 E-value: 6.25e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 8 RSIQFKITLIYVLLIIIAMQIIGVYFVNQVEKSL----------------------ISSYEQSLNQRIDNLSYYI---EQ 62
Cdd:NF040691 3 RSLQLRVVAITLLLSLVVILVLGVVLALQITNGLldnrvdaalgdsrrartqaqsqLNASDASTSDSAQQLLRTTllsVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 63 EYKSDNDSTVIkDDVSRILNDFTKSDEVREISFVDKSYEVvgsSKPYGEEVAGKQTTDLIfkrifstkQSYLRKYYDpKS 142
Cdd:NF040691 83 ASASGAMQGAF-DVVLLVPGDDPSGLGPRASGSVGLVSQI---PEELREAVAGGQVAQQY--------QSVALPSGD-GS 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 143 KIRVLISAKPVMTENQEVVGaIYVVASMEDVFNQMKTINTILASGtGLALVLTALLGIFL-ARTITHPLSDMRKQAMELA 221
Cdd:NF040691 150 SAPALVVGTPVTLPVAGNYE-LYLLFPLEDEQSTLALVRGTLLLG-GLALVVLLGLIAWLvTRQVVAPVRSAARTAERFA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 222 KGNFSRKVKKYGHDEIGQLATTFNhltreledaqAMTEgerrklasviaymtdgviatnrngaiillnspalellnvsre 301
Cdd:NF040691 228 AGDLSERMPVKGEDDLARLARSFN----------QMAD------------------------------------------ 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 302 talempitsllgiqenytfedlveqqdsmlleierddeltvlrvnfsVIQREhgkidgliaviydVTEQEKMDQERREFV 381
Cdd:NF040691 256 -----------------------------------------------SLQRQ-------------IRQLEELSRLQQRFV 275
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 382 ANVSHELRTPLTTMRSYLEALAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNREWIQIVRFISLI 461
Cdd:NF040691 276 SDVSHELRTPLTTIRMAADVIHDSRDDFDPATARSAELLHTELDRFESLLSDLLEISRFDAGAAELDVEPVDLRPLVRRV 355
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 462 IDRFEMTKEQH-VEFIRNLPDRNLYVEIDQDKITQVLDNIISNALKYSpEGGHVTFSIDVNEEEelLYISVKDEGIGIPK 540
Cdd:NF040691 356 VDALRQLAERAgVELRVDAPGTPVVAEVDPRRVERVLRNLVVNAIEHG-EGKPVVVTVAQDDTA--VAVTVRDHGVGLKP 432
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*....
gi 518546137 541 KDVEKVFDRFYRVDKARTRKLGGTGLGLAIAREMVQAHGGDIWADSIEGKGTTITFTLP 599
Cdd:NF040691 433 GEVALVFDRFWRADPARARTTGGTGLGLAIALEDARLHGGWLEAWGRPGQGSQFRLTLP 491
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
262-599 |
8.72e-45 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 164.80 E-value: 8.72e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 262 RRKLASVI-------AYMTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLGIQEnytFEDLVEQQD-SMLLE 333
Cdd:PRK11006 90 RRELGNLIkrfrsgaESLPDAVVLTTEEGNIFWCNGLAQQLLGFRWPEDNGQNILNLLRYPE---FTQYLKTRDfSRPLT 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 334 IERDDELTVlrvNFSVIQREHGKidgLIAVIYDVTEQEKMDQERREFVANVSHELRTPLTTMRSYLEAL----AEGAWEN 409
Cdd:PRK11006 167 LVLNNGRHL---EIRVMPYTEGQ---LLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMqdqpLEGALRE 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 410 KDiaprfLMVTQNETERMIRLVNDLLQLSKFD-SKDYQFNrewiQIVRfISLIIDRFE-----MTKEQHvEFIRNLpDRN 483
Cdd:PRK11006 241 KA-----LHTMREQTQRMEGLVKQLLTLSKIEaAPTIDLN----EKVD-VPMMLRVLEreaqtLSQGKH-TITFEV-DNS 308
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 484 LYVEIDQDKITQVLDNIISNALKYSPEGGHVTFSIDVNEEEELLyiSVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGG 563
Cdd:PRK11006 309 LKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGAEF--SVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGG 386
|
330 340 350
....*....|....*....|....*....|....*.
gi 518546137 564 TGLGLAIAREMVQAHGGDIWADSIEGKGTTITFTLP 599
Cdd:PRK11006 387 SGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLP 422
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
249-599 |
2.66e-43 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 158.81 E-value: 2.66e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 249 RELEDAQAMTEGERRKLASVIAYMTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLGIQENYTFEDLVEQQD 328
Cdd:COG4191 1 ALRLLLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 329 SMLLEIERDDELTVLRVNFSVIQREHGKIDGLIAviyDVTEQEKMDQERR----------------EFVANVSHELRTPL 392
Cdd:COG4191 81 LLGLLLLLLLEALLLLLLAALDAEENAELEELER---DITELERAEEELRelqeqlvqseklaalgELAAGIAHEINNPL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 393 TTMRSYLEALAE--GAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDyqfnREWIQIVRFISLIIDRFE-MTK 469
Cdd:COG4191 158 AAILGNAELLRRrlEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRDEEE----REPVDLNELIDEALELLRpRLK 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 470 EQHVEFIRNLPDRNLYVEIDQDKITQVLDNIISNALKYSPEGGHVTFSIDVNEEEELLYISVKDEGIGIPKKDVEKVFDR 549
Cdd:COG4191 234 ARGIEVELDLPPDLPPVLGDPGQLEQVLLNLLINAIDAMEEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEP 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 518546137 550 FYRvdkarTRKLG-GTGLGLAIAREMVQAHGGDIWADSIEGKGTTITFTLP 599
Cdd:COG4191 314 FFT-----TKPVGkGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLP 359
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
488-601 |
7.69e-41 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 143.94 E-value: 7.69e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 488 IDQDKITQVLDNIISNALKYSPEGGHVTfsIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKaRTRKLGGTGLG 567
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRIT--VTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLG 77
|
90 100 110
....*....|....*....|....*....|....
gi 518546137 568 LAIAREMVQAHGGDIWADSIEGKGTTITFTLPYK 601
Cdd:smart00387 78 LSIVKKLVELHGGEISVESEPGGGTTFTITLPLE 111
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
493-598 |
7.37e-40 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 140.82 E-value: 7.37e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 493 ITQVLDNIISNALKYSPEGGHVTFSIDvnEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRklGGTGLGLAIAR 572
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLR--QEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREG--GGTGLGLAIVR 76
|
90 100
....*....|....*....|....*.
gi 518546137 573 EMVQAHGGDIWADSIEGKGTTITFTL 598
Cdd:cd00075 77 RIVEAHGGRITVESEPGGGTTFTVTL 102
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
371-607 |
3.82e-39 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 149.78 E-value: 3.82e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 371 EKMDQERREFVANVSHELRTPLTTMRSYLEALAEGAwenKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNRE 450
Cdd:PRK10549 234 EKNEQMRRDFMADISHELRTPLAVLRGELEAIQDGV---RKFTPESVASLQAEVGTLTKLVDDLHQLSLSDEGALAYRKT 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 451 WIQIVRFISLII----DRFEmTKEQHVEFirNLPDrNLYVEIDQDKITQVLDNIISNALKYSPEGGHVTfsIDVNEEEEL 526
Cdd:PRK10549 311 PVDLVPLLEVAGgafrERFA-SRGLTLQL--SLPD-SATVFGDPDRLMQLFNNLLENSLRYTDSGGSLH--ISAEQRDKT 384
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 527 LYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGLGLAIAREMVQAHGGDIWADSIEGKGTTITFTLPYKEEQED 606
Cdd:PRK10549 385 LRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERDLQR 464
|
.
gi 518546137 607 D 607
Cdd:PRK10549 465 E 465
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
149-599 |
8.11e-39 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 148.82 E-value: 8.11e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 149 SAKPVMTENQEVvGAIyVVASMEDVF---------NQMKTINTILAsgtgLALVLTALLGIFLARTITHPLSDMRKQAME 219
Cdd:NF012163 128 TRRPILVNGQEV-GAL-GASPVERLTrntdinfdsQQKRASWLIVA----LALLLAALAAFLLARGLLAPVKRLVEATHR 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 220 LAKGNFSRKVKKYGHDEIGQLATTFNHLTRELEDAQAMtegerrklasviaymtdgviatnrngaiillnspalellnvs 299
Cdd:NF012163 202 LAAGDYTTRVTPTSNDELGKLAQDFNQLASTLEKNEQM------------------------------------------ 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 300 retalempitsllgiqenytfedlveqqdsmlleierddeltvlrvnfsviqrehgkidgliaviydvteqekmdqeRRE 379
Cdd:NF012163 240 -----------------------------------------------------------------------------RRD 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 380 FVANVSHELRTPLTTMRSYLEALAEGAwenKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNREWIQIVRFIS 459
Cdd:NF012163 243 FMADISHELRTPLAVLRAELEAIQDGI---RKFTPESLDSLQAEVGTLTKLVDDLHDLSMSDEGALAYQKASVDLVPLLE 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 460 LIIDRFEMTKEQH-VEFIRNLPDRNLYVEiDQDKITQVLDNIISNALKYSPEGGHVtfSIDVNEEEELLYISVKDEGIGI 538
Cdd:NF012163 320 VEGGAFRERFASAgLELEVSLPDSSLVFG-DRDRLMQLFNNLLENSLRYTDSGGSL--HISASQRPKEVTLTVADSAPGV 396
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 518546137 539 PKKDVEKVFDRFYRVDKARTRKLGGTGLGLAIAREMVQAHGGDIWADSIEGKGTTITFTLP 599
Cdd:NF012163 397 SDEQLARLFERFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTLHAAHSPLGGLRIVVTLP 457
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
495-599 |
2.82e-38 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 136.85 E-value: 2.82e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 495 QVLDNIISNALKYSPEGgHVTFSIDVNEEEE---LLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGLGLAIA 571
Cdd:cd16922 3 QILLNLLGNAIKFTEEG-EVTLRVSLEEEEEdgvQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAIS 81
|
90 100
....*....|....*....|....*...
gi 518546137 572 REMVQAHGGDIWADSIEGKGTTITFTLP 599
Cdd:cd16922 82 KKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
370-599 |
7.09e-36 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 138.55 E-value: 7.09e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 370 QEKMD-QERREF----VANVSHELRTPLTTMRSYLEALAEGAWENKDIAP-----RFLMVTQNETERMIRLVNDLLQLSK 439
Cdd:PRK09303 139 QENETlLEQLKFkdrvLAMLAHDLRTPLTAASLALETLELGQIDEDTELKpalieQLQDQARRQLEEIERLITDLLEVGR 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 440 FDSKDYQFNREWIQIVRFISLIIDRFEMT-KEQHVEFIRNLPDRNLYVEIDQDKITQVLDNIISNALKYSPEGGHVTFSI 518
Cdd:PRK09303 219 TRWEALRFNPQKLDLGSLCQEVILELEKRwLAKSLEIQTDIPSDLPSVYADQERIRQVLLNLLDNAIKYTPEGGTITLSM 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 519 dVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDkaRTRKLGGTGLGLAIAREMVQAHGGDIWADSIEGKGTTITFTL 598
Cdd:PRK09303 299 -LHRTTQKVQVSICDTGPGIPEEEQERIFEDRVRLP--RDEGTEGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTL 375
|
.
gi 518546137 599 P 599
Cdd:PRK09303 376 P 376
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
489-602 |
7.48e-36 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 130.18 E-value: 7.48e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 489 DQDKITQVLDNIISNALKYSPEGGHVTFSIdvnEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKartRKLGGTGLGL 568
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAGEITVTL---SEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGL 75
|
90 100 110
....*....|....*....|....*....|....
gi 518546137 569 AIAREMVQAHGGDIWADSIEGKGTTITFTLPYKE 602
Cdd:pfam02518 76 SIVRKLVELLGGTITVESEPGGGTTVTLTLPLAQ 109
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
250-599 |
5.78e-34 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 135.63 E-value: 5.78e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 250 ELEDAQAMTEGERRKLASVIAYMTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLG------IQENytFEDL 323
Cdd:COG5805 144 KKKKIEEILQEQEERLQTLIENSPDLICVIDTDGRILFINESIERLFGAPREELIGKNLLELLHpcdkeeFKER--IESI 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 324 VEQQDSMLLE---IERDDELTVLRVNFSVIQREHGKIDGLIAVIYDVTEQEKMDQERR---------EFVANVSHELRTP 391
Cdd:COG5805 222 TEVWQEFIIEreiITKDGRIRYFEAVIVPLIDTDGSVKGILVILRDITEKKEAEELMArseklsiagQLAAGIAHEIRNP 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 392 LTTMRSYLEALAEGAWENKDIAPrfLMVTqnETERMIRLVNDLLQLSKFDSkdYQFNREWIQ--IVRFISLiidrfeMTK 469
Cdd:COG5805 302 LTSIKGFLQLLQPGIEDKEEYFD--IMLS--ELDRIESIISEFLALAKPQA--VNKEKENINelIQDVVTL------LET 369
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 470 E---QHVEFIRNLPDRNLYVEIDQDKITQVLDNIISNALKYSPEGGhvTFSIDVNEEEELLYISVKDEGIGIPKKDVEKV 546
Cdd:COG5805 370 EailHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGG--TITIHTEEEDNSVIIRVIDEGIGIPEERLKKL 447
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 518546137 547 FDRFYrvdkarTRKLGGTGLGLAIAREMVQAHGGDIWADSIEGKGTTITFTLP 599
Cdd:COG5805 448 GEPFF------TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
380-599 |
6.53e-34 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 134.82 E-value: 6.53e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 380 FVANVSHELRTPLTTM-----------RS---YLEALAEgawenkdiaprflmvTQNETERMIRLVNDLLQLSKFDSKDY 445
Cdd:TIGR01386 244 FSADLAHELRTPLTNLlgqtqvalsqpRTgeeYREVLES---------------NLEELERLSRMVSDMLFLARADNGQL 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 446 QFNREWIQIVRFISLIIDRFEMTKEQhvEFIRNLPDRNLYVEIDQDKITQVLDNIISNALKYSPEGGHVTfsIDVNEEEE 525
Cdd:TIGR01386 309 ALERVRLDLAAELAKVAEYFEPLAEE--RGVRIRVEGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTIT--VRIERRSD 384
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 518546137 526 LLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGLGLAIAREMVQAHGGDIWADSIEGKgTTITFTLP 599
Cdd:TIGR01386 385 EVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDGK-TRFILRFP 457
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-599 |
9.18e-33 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 121.28 E-value: 9.18e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 493 ITQVLDNIISNALKYSPEGGHVTFSIDVNEeeelLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGLGLAIAR 572
Cdd:cd16949 1 LARALENVLRNALRYSPSKILLDISQDGDQ----WTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAE 76
|
90 100
....*....|....*....|....*..
gi 518546137 573 EMVQAHGGDIWADSIEGKGTTITFTLP 599
Cdd:cd16949 77 RAIEQHGGKIKASNRKPGGLRVRIWLP 103
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
375-599 |
8.10e-32 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 128.51 E-value: 8.10e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 375 QERreFVANVSHELRTPLTTMRSYLeALA---EGawENKDIApRFlmvtQNETERMIRLVNDLLQLSKFDSKDyQFNREW 451
Cdd:PRK09470 243 QQR--LLSDISHELRTPLTRLQLAT-ALLrrrQG--ESKELE-RI----ETEAQRLDSMINDLLVLSRNQQKN-HLERET 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 452 IQIVRFISLIID--RFEMTKEQHVEFIRNLPDRnLYVEIDQDKITQVLDNIISNALKYSPEGGHVTFSIDVNEeeelLYI 529
Cdd:PRK09470 312 FKANSLWSEVLEdaKFEAEQMGKSLTVSAPPGP-WPINGNPNALASALENIVRNALRYSHTKIEVAFSVDKDG----LTI 386
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 518546137 530 SVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGLGLAIAREMVQAHGGDIWA-DSIEGkGTTITFTLP 599
Cdd:PRK09470 387 TVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAeDSPLG-GLRLTIWLP 456
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
294-599 |
2.03e-31 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 130.67 E-value: 2.03e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 294 ELLNVSRETALEMPItslLGIQENYTFEDLVEQQDSMLLEIE-RDDEL--TVLRVNFSVIQREHGKidgliaviydvTEQ 370
Cdd:TIGR02956 392 RAIEAFRDTAAHNLK---LQADERQVAQELQEHKESLEQLVAqRTQELaeTNERLNAEVKNHAKAR-----------AEA 457
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 371 EKMDQERREFVANVSHELRTPLTTMRSYLEALAEgawenKDIAP---RFLMVTQNETERMIRLVNDLLQLSKFDSKDYQF 447
Cdd:TIGR02956 458 EEANRAKSAFLATMSHEIRTPLNGILGTLELLGD-----TGLTSqqqQYLQVINRSGESLLDILNDILDYSKIEAGHLSI 532
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 448 NREWIQIVRFISLIIDRFEM-TKEQHVEFIRNLPDR-NLYVEIDQDKITQVLDNIISNALKYSPEgGHVTFSIDVNEEEE 525
Cdd:TIGR02956 533 SPRPFDLNALLDDVHHLMVSrAQLKGIQLRLNIPEQlPNWWQGDGPRIRQVLINLVGNAIKFTDR-GSVVLRVSLNDDSS 611
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 518546137 526 LLyISVKDEGIGIPKKDVEKVFDRFYRVDKarTRKLGGTGLGLAIAREMVQAHGGDIWADSIEGKGTTITFTLP 599
Cdd:TIGR02956 612 LL-FEVEDTGCGIAEEEQATLFDAFTQADG--RRRSGGTGLGLAISQRLVEAMDGELGVESELGVGSCFWFTLP 682
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
368-606 |
7.45e-31 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 128.62 E-value: 7.45e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 368 TEQEKMDQERRE----FVANVSHELRTPLTTMRSYLEALA-EGAWENKDIAPRFLMVTQnETERMIRLVNDLLQLSKFDS 442
Cdd:PRK10490 651 EEQARLASEREQlrnaLLAALSHDLRTPLTVLFGQAEILTlDLASEGSPHARQASEIRQ-QVLNTTRLVNNLLDMARIQS 729
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 443 KDYQFNREWIQIVRFISLIIDRFE-MTKEQHVEFirNLPDRNLYVEIDQDKITQVLDNIISNALKYSpeGGHVTFSIDVN 521
Cdd:PRK10490 730 GGFNLRKEWLTLEEVVGSALQMLEpGLSGHPINL--SLPEPLTLIHVDGPLFERVLINLLENAVKYA--GAQAEIGIDAH 805
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 522 EEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTrkLGGTGLGLAIAREMVQAHGGDIWADSIEGKGTTITFTLPYK 601
Cdd:PRK10490 806 VEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESA--IPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLPLE 883
|
250
....*....|.
gi 518546137 602 ------EEQED 606
Cdd:PRK10490 884 tppeleEFHED 894
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
307-599 |
2.01e-29 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 121.80 E-value: 2.01e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 307 PITSLLGIQENYTFEDLVEQQDSMLLEIERddELTVLRVNFsviqrehgkidgLIAVIYDV-TEQEKmdqerreFVANVS 385
Cdd:PRK09835 212 PIRSVSRQIQNITSKDLDVRLDPQTVPIEL--EQLVLSFNH------------MIERIEDVfTRQSN-------FSADIA 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 386 HELRTPLTTMRSYLE-ALAEGAWEN--KDIaprfLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNREWIQIVRFISLII 462
Cdd:PRK09835 271 HEIRTPITNLITQTEiALSQSRSQKelEDV----LYSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKMLDLADEVGKVF 346
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 463 DRFE-MTKEQHVEFirNLPDRNLYVEIDQDKITQVLDNIISNALKYSPEGGHVTfsIDVNEEEELLYISVKDEGIGIPKK 541
Cdd:PRK09835 347 DFFEaWAEERGVEL--RFVGDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAIT--VRCQEVDHQVQLVVENPGTPIAPE 422
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 518546137 542 DVEKVFDRFYRVDKARTRKLGGTGLGLAIAREMVQAHGGDIWADSiEGKGTTITFTLP 599
Cdd:PRK09835 423 HLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTS-DARGTRFVISLP 479
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
377-599 |
9.85e-29 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 118.94 E-value: 9.85e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 377 RREFVANVSHELRTPLTTMRSYLEAL-----AEGAWENKDIaprflmvTQNETermirLVNDLLQLSKFDSKDYQFNREW 451
Cdd:PRK10604 212 KKQLIDGIAHELRTPLVRLRYRLEMSdnlsaAESQALNRDI-------GQLEA-----LIEELLTYARLDRPQNELHLSE 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 452 IQIVRFISLIIDRFEMTkEQHVEFIRNLPDRNLYVEIDQDKITQVLDNIISNALKYSpeGGHVTFSIDVNEEEELLyiSV 531
Cdd:PRK10604 280 PDLPAWLSTHLADIQAV-TPEKTVRLDTPHQGDYGALDMRLMERVLDNLLNNALRYA--HSRVRVSLLLDGNQACL--IV 354
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 518546137 532 KDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGLGLAIAREMVQAHGGDIWADSIEGKGTTITFTLP 599
Cdd:PRK10604 355 EDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWP 422
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
382-607 |
2.68e-28 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 118.35 E-value: 2.68e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 382 ANVSHELRTPLTTMRSYLEALAEGAWENKDiAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNReWIQIVRFISLI 461
Cdd:PRK10364 242 AGVAHEIRNPLSSIKGLAKYFAERAPAGGE-AHQLAQVMAKEADRLNRVVSELLELVKPTHLALQAVD-LNDLINHSLQL 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 462 IDRFEMTKEQHVEFIRN--LPDrnlyVEIDQDKITQVLDNIISNALKYSPEGGHVTFSidVNEEEELLYISVKDEGIGIP 539
Cdd:PRK10364 320 VSQDANSREIQLRFTANdtLPE----IQADPDRLTQVLLNLYLNAIQAIGQHGVISVT--ASESGAGVKISVTDSGKGIA 393
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 518546137 540 KKDVEKVFDRFYrvdkarTRKLGGTGLGLAIAREMVQAHGGDIWADSIEGKGTTITFTLPYKEEQEDD 607
Cdd:PRK10364 394 ADQLEAIFTPYF------TTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVNITRRDP 455
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
355-599 |
1.38e-27 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 118.12 E-value: 1.38e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 355 GKIDGLIAVIYDVTEQ-------EKMDQERREFVANVSHELRTPLttmrsylealaegaweNKDIA-PRFLMVTQNETER 426
Cdd:PRK11091 254 GKRHGLMGFGRDITERkryqdalEKASRDKTTFISTISHELRTPL----------------NGIVGlSRILLDTELTAEQ 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 427 M----------IRL---VNDLLQLSKFDskdyqfnREWIQI----VRFISLIID--------------RFEMTKEQHvef 475
Cdd:PRK11091 318 RkylktihvsaITLgniFNDIIDMDKME-------RRKLQLdnqpIDFTDFLADlenlsglqaeqkglRFDLEPLLP--- 387
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 476 irnLPDrnlYVEIDQDKITQVLDNIISNALKYSPEGGhVTFSIdVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRV-D 554
Cdd:PRK11091 388 ---LPH---KVITDGTRLRQILWNLISNAVKFTQQGG-VTVRV-RYEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVkD 459
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 518546137 555 KARTRKLGGTGLGLAIAREMVQAHGGDIWADSIEGKGTTITFTLP 599
Cdd:PRK11091 460 SHGGKPATGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIH 504
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
380-599 |
1.89e-27 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 116.10 E-value: 1.89e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 380 FVANVSHELRTPLTTMRSYLEALAEGAWEnkDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNREWIQIVRFIS 459
Cdd:PRK11100 259 YVQTLTHELKSPLAAIRGAAELLQEDPPP--EDRARFTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLE 336
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 460 LIIDRFEMTKEQHVEFIRNLPDrNLYVEIDQDKITQVLDNIISNALKYSPEGGHVTFSIDVNEEEelLYISVKDEGIGIP 539
Cdd:PRK11100 337 ELVEAREAQAAAKGITLRLRPD-DARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQ--VALSVEDQGPGIP 413
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 518546137 540 KKDVEKVFDRFY---RVDKARTrklgGTGLGLAIAREMVQAHGGDIWADSIEGKGTTITFTLP 599
Cdd:PRK11100 414 DYALPRIFERFYslpRPANGRK----STGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLP 472
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
489-599 |
1.97e-27 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 106.78 E-value: 1.97e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 489 DQDKITQVLDNIISNALKYSPEGGhvTFSIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGLGL 568
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGG--KLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGL 78
|
90 100 110
....*....|....*....|....*....|.
gi 518546137 569 AIAREMVQAHGGDIWADSIEGKGTTITFTLP 599
Cdd:cd16946 79 AICHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
237-603 |
4.75e-27 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 113.40 E-value: 4.75e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 237 IGQLATTFNHLTRELEDAQAMTEGERRKLASVIAYMTDGVIATNRNGAIILLNSPALELLNVSretALEMPITSLLgiqe 316
Cdd:COG3290 58 LILLLLLLLLLAALLLKLLEEIARLVEEREAVLESIREGVIAVDRDGRITLINDAARRLLGLD---AIGRPIDEVL---- 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 317 nytfedlveqqDSMLLEIERDDELT----VLRVNFSVIqREHGKIDGLIAVIYDVTEQEKMDQE---RREFVANV---SH 386
Cdd:COG3290 131 -----------AEVLETGERDEEILlngrVLVVNRVPI-RDDGRVVGAVATFRDRTELERLEEElegVKELAEALraqRH 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 387 ELRTPLTTMRSYLEalaegawenkdiaprflmvtQNETERMIRLVNDLLQLSKfdsKDYQFNREWIQIVRFISLIIDRFE 466
Cdd:COG3290 199 DFRNHLHTISGLLQ--------------------LGEYDEALEYIDEISEELQ---ELIDSLLSRIGNPVLAALLLGKAA 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 467 MTKEQHVEFIRNLPDRNLYVEIDQDKITQVLDNIISNAL----KYSPEGGHVTFSIDVNEEEelLYISVKDEGIGIPKKD 542
Cdd:COG3290 256 RARERGIDLTIDIDSDLPDLPLSDTDLVTILGNLLDNAIeaveKLPEEERRVELSIRDDGDE--LVIEVEDSGPGIPEEL 333
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 518546137 543 VEKVFDRFYRvdkarTRKLGGTGLGLAIAREMVQAHGGDIWADSIEGKGTTITFTLPYKEE 603
Cdd:COG3290 334 LEKIFERGFS-----TKLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEGE 389
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
499-599 |
3.06e-26 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 103.05 E-value: 3.06e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 499 NIISNALKYSPEGGHVTfsIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGLGLAIAREMVQAH 578
Cdd:cd16952 7 NLVSNAVKYTPPSDTIT--VRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVMSRH 84
|
90 100
....*....|....*....|.
gi 518546137 579 GGDIWADSIEGKGTTITFTLP 599
Cdd:cd16952 85 DARLLIASELGKGSRFTCLFP 105
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-599 |
4.78e-26 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 102.41 E-value: 4.78e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 493 ITQVLDNIISNALKYSPEGGHVTFSIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKarTRKLGGTGLGLAIAR 572
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHS--REEYEGTGVGLAIVR 78
|
90 100
....*....|....*....|....*..
gi 518546137 573 EMVQAHGGDIWADSIEGKGTTITFTLP 599
Cdd:cd16921 79 KIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
377-605 |
1.49e-25 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 112.52 E-value: 1.49e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 377 RREFVANVSHELRTPLTTMRSYLEALAeGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNREWIQIVR 456
Cdd:PRK09959 712 KSQFLATMSHEIRTPISSIMGFLELLS-GSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWVDIPT 790
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 457 FISLIIDRF---EMTKEQHVEFIRNLPDRNLyVEIDQDKITQVLDNIISNALKYSPEGG-HVTFS-IDVNEEEELLYISV 531
Cdd:PRK09959 791 LVQNTCHSFgaiAASKSIALSCSSTFPDHYL-VKIDPQAFKQVLSNLLSNALKFTTEGAvKITTSlGHIDDNHAVIKMTI 869
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 518546137 532 KDEGIGIPKKDVEKVFDRFYRVDKARTRKlgGTGLGLAIAREMVQAHGGDIWADSIEGKGTTITFTLPYKEEQE 605
Cdd:PRK09959 870 MDSGSGLSQEEQQQLFKRYSQTSAGRQQT--GSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPVEISQQ 941
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
382-582 |
2.44e-25 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 107.77 E-value: 2.44e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 382 ANVSHELRTPLTTMRSYLEALAEGAWENKDIAPRFLMvtqNETERMIRLVNDLLQLSKFDSKDYQFNREWIQ----IVRF 457
Cdd:NF012226 143 AAIAHELRTPITILQGRLQGILDGVFEPDPALFKSLL---NQVEGLSHLVEDLRTLSLVENQQLRLNYESVDlkdsIEKV 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 458 ISLIIDRFEmTKEQHVEFirNLPDRNLYVeiDQDKITQVLDNIISNALKYSpEGGHVTFSIDVNEEEELLYIsvKDEGIG 537
Cdd:NF012226 220 LKMFEDRLE-QAQLTIVL--NLTATPVFC--DRRRIEQVLIALIDNAIRYA-NAGKLKISSSVIQDDWILQI--EDEGPG 291
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 518546137 538 IPKKDVEKVFDRFYRVDKARTRKLGGTGLGLAIAREMVQAHGGDI 582
Cdd:NF012226 292 IAEEYQQDLFNPFFRLEQSRNKEFGGTGLGLAVVHAIVIAHKGSI 336
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
378-599 |
5.16e-23 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 103.67 E-value: 5.16e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 378 REFVANVSHELRTPLTTMRSYLEALAEGAWENKDiaPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNREWIQIVRF 457
Cdd:TIGR03785 486 ENMSSRLSHELRTPVAVVRSSLENLELQALEQEK--QKYLERAREGTERLSMILNNMSEATRLEQAIQSAEVEDFDLSEV 563
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 458 ISLIIDRFEMTKEQHVeFIRNLPDRNLYVEIDQDKITQVLDNIISNALKYSPEGGHVTFSIDVNEEEELlyISVKDEGIG 537
Cdd:TIGR03785 564 LSGCMQGYQMTYPPQR-FELNIPETPLVMRGSPELIAQMLDKLVDNAREFSPEDGLIEVGLSQNKSHAL--LTVSNEGPP 640
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 518546137 538 IPKKDVEKVFDRFYRVDKARTRKLGGTGLGLAIAREMVQAHGGDIWADSI-EGKGTTITFTLP 599
Cdd:TIGR03785 641 LPEDMGEQLFDSMVSVRDQGAQDQPHLGLGLYIVRLIADFHQGRIQAENRqQNDGVVFRISLP 703
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
489-599 |
6.40e-23 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 93.71 E-value: 6.40e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 489 DQDKITQVLDNIISNALKYSPEGGHVTFSIDVNEEEELLyISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGLGL 568
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFRLNRFL-LTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGL 79
|
90 100 110
....*....|....*....|....*....|.
gi 518546137 569 AIAREMVQAHGGDIWADSIEGKGTTITFTLP 599
Cdd:cd16925 80 SIVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
478-598 |
1.14e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 93.73 E-value: 1.14e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 478 NLPDRNLYVEIDQDKITQVLDNIISNALKYSPEGGHVTFSIdvNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKAR 557
Cdd:cd16947 6 NIPDRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTL--REDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSR 83
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 518546137 558 TRKLGGTGLGLAIAREMVQAHGGDIWADSIEGKGTTITFTL 598
Cdd:cd16947 84 NSAKQGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
361-599 |
1.18e-22 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 103.13 E-value: 1.18e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 361 IAVIYDVTEQEKMDQERRE--------------FVANVSHELRTPLTTMRSYLE-----ALAEGAwenkdiaPRFLMVTQ 421
Cdd:PRK10841 417 ICVLVDVSARVKMEESLQEmaqaaeqasqsksmFLATVSHELRTPLYGIIGNLDllqtkELPKGV-------DRLVTAMN 489
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 422 NETERMIRLVNDLLQLSKFDSKDY-----QFN-REWIQ--IVRFISLIIdRFEMTKEQHVEfirnlPDRNLYVEIDQDKI 493
Cdd:PRK10841 490 NSSSLLLKIISDILDFSKIESEQLkieprEFSpREVINhiTANYLPLVV-KKRLGLYCFIE-----PDVPVALNGDPMRL 563
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 494 TQVLDNIISNALKYSPEGGHVtfsIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGLGLAIARE 573
Cdd:PRK10841 564 QQVISNLLSNAIKFTDTGCIV---LHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEK 640
|
250 260
....*....|....*....|....*.
gi 518546137 574 MVQAHGGDIWADSIEGKGTTITFTLP 599
Cdd:PRK10841 641 LINMMDGDISVDSEPGMGSQFTIRIP 666
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
370-580 |
1.63e-22 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 99.27 E-value: 1.63e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 370 QEKMDQERrEFVANVSHELRTPLTTMRSYLEALAEGAweNKDIAPRFLMVTQneterMIRLVNDLLQLS----KFDSKDY 445
Cdd:PRK10755 131 TSTLDQER-LFTADVAHELRTPLAGIRLHLELLEKQH--HIDVAPLIARLDQ-----MMHTVEQLLQLAragqSFSSGHY 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 446 QfNREWIQIVrfISLIIDRF-EMTKEQHVEFIRNLPDRNLYVEIDQDKITQVLDNIISNALKYSPEGGHVTFSIDvnEEE 524
Cdd:PRK10755 203 Q-TVKLLEDV--ILPSQDELsEMLEQRQQTLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLS--QED 277
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 518546137 525 ELLYISVKDEGIGIPKKDVEKVFDRFYRVDkartRKLGGTGLGLAIAREMVQAHGG 580
Cdd:PRK10755 278 GGAVLAVEDEGPGIDESKCGELSKAFVRMD----SRYGGIGLGLSIVSRITQLHHG 329
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
379-601 |
2.03e-22 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 99.94 E-value: 2.03e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 379 EFVANVSHELRTPLTTMRSYLEaLAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQ---FNREWIQIV 455
Cdd:COG5806 203 ELAASIAHEVRNPLTVVRGFIQ-LLQEPELSDEKRKQYIRIALEELDRAEAIITDYLTFAKPQPEKLEkidVSEELEHVI 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 456 RFISliidrfEMTKEQHVEfIRNLPDRNLYVEIDQDKITQVLDNIISNALKYSPEGGhvTFSIDVNEEEELLYISVKDEG 535
Cdd:COG5806 282 DVLS------PYANMNNVE-IQTELEPGLYIEGDRQKLQQCLINIIKNGIEAMPNGG--TLTIDVSIDKNKVIISIKDTG 352
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518546137 536 IGIPKKDVEKVFDRFYrvdkarTRKLGGTGLGLAIAREMVQAHGGDIWADSIEGKGTTITFTLPYK 601
Cdd:COG5806 353 VGMTKEQLERLGEPYF------STKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITLPLA 412
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
369-605 |
2.51e-22 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 102.03 E-value: 2.51e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 369 EQEKMDQERREFVANVSHELRTPLTTMRSYLEALAEGAWENKDIapRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFN 448
Cdd:PRK15347 390 RAEQANKRKSEHLTTISHEIRTPLNGVLGALELLQNTPLTAEQM--DLADTARQCTLSLLAIINNLLDFSRIESGQMTLS 467
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 449 REWIQIVrfisLIIDRfEMTKEQHVEFIRNL-------PDRNLYVEIDQDKITQVLDNIISNALKYSPEGGhvtFSIDVN 521
Cdd:PRK15347 468 LEETALL----PLLDQ-AMLTIQGPAQSKSLtlrtfvgAHVPLYLHLDSLRLRQILVNLLGNAVKFTETGG---IRLRVK 539
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 522 EEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKartrKLGGTGLGLAIAREMVQAHGGDIWADSIEGKGTTITFTLPYK 601
Cdd:PRK15347 540 RHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADT----HSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLPLN 615
|
....
gi 518546137 602 EEQE 605
Cdd:PRK15347 616 EYAP 619
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
496-599 |
2.70e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 91.96 E-value: 2.70e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 496 VLDNIISNALKYSPEGGHVTFSIDVNEEEELLyiSVKDEGIGIPKKDVEKVFDRFYRVDKARtRKLGGTGLGLAIAREMV 575
Cdd:cd16948 9 IIGQIVSNALKYSKQGGKIEIYSETNEQGVVL--SIKDFGIGIPEEDLPRVFDKGFTGENGR-NFQESTGMGLYLVKKLC 85
|
90 100
....*....|....*....|....
gi 518546137 576 QAHGGDIWADSIEGKGTTITFTLP 599
Cdd:cd16948 86 DKLGHKIDVESEVGEGTTFTITFP 109
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
489-596 |
1.76e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 89.44 E-value: 1.76e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 489 DQDKITQVLDNIISNALKYSPEGGHVtfSIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKlGGTGLGL 568
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTV--SISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSG-GHYGMGL 77
|
90 100
....*....|....*....|....*...
gi 518546137 569 AIAREMVQAHGGDIWADSIEGKGTTITF 596
Cdd:cd16975 78 YIAKNLVEKHGGSLIIENSQKGGAEVTV 105
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
496-599 |
2.61e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 89.03 E-value: 2.61e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 496 VLDNIISNALKYSpeggHVTFSIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGLGLAIAREMV 575
Cdd:cd16939 4 ALDNLLRNALRYA----HRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVA 79
|
90 100
....*....|....*....|....
gi 518546137 576 QAHGGDIWADSIEGKGTTITFTLP 599
Cdd:cd16939 80 LWHGGHVECDDSELGGACFRLTWP 103
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
496-599 |
2.88e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 88.98 E-value: 2.88e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 496 VLDNIISNALKYSPEGGHVtfSIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKArtRKLGGTGLGLAIAREMV 575
Cdd:cd16923 4 VFSNLLSNAIKYSPENTRI--YITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNS--RNTEGAGLGLSIAKAII 79
|
90 100
....*....|....*....|....
gi 518546137 576 QAHGGDIWAdSIEGKGTTITFTLP 599
Cdd:cd16923 80 ELHGGSASA-EYDDNHDLFKVRLP 102
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-599 |
3.31e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 88.61 E-value: 3.31e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 493 ITQVLDNIISNALK----YSPEGGHVTFSIDVNEEEELLyISVKDEGIGIPKKDVEKVFDRFYrvdkarTRKLGGTGLGL 568
Cdd:cd16920 1 IQQVLINLVRNGIEamseGGCERRELTIRTSPADDRAVT-ISVKDTGPGIAEEVAGQLFDPFY------TTKSEGLGMGL 73
|
90 100 110
....*....|....*....|....*....|.
gi 518546137 569 AIAREMVQAHGGDIWADSIEGKGTTITFTLP 599
Cdd:cd16920 74 SICRSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-599 |
1.78e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 86.71 E-value: 1.78e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 493 ITQVLDNIISNALKYSPEGGhvTFSIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRvdkarTRKLG-GTGLGLAIA 571
Cdd:cd16943 4 LNQVLLNLLVNAAQAMEGRG--RITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFT-----TKPVGeGTGLGLSLS 76
|
90 100
....*....|....*....|....*...
gi 518546137 572 REMVQAHGGDIWADSIEGKGTTITFTLP 599
Cdd:cd16943 77 YRIIQKHGGTIRVASVPGGGTRFTIILP 104
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
482-595 |
2.05e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 86.69 E-value: 2.05e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 482 RNLYVEIDQDKITQVLDNIISNALKYSPEGGHVtfSIDVNEEEELLyISVKDEGIGIPKKDVEKVFDRFYRVDKartRKL 561
Cdd:cd16940 3 ADIQVQGDALLLFLLLRNLVDNAVRYSPQGSRV--EIKLSADDGAV-IRVEDNGPGIDEEELEALFERFYRSDG---QNY 76
|
90 100 110
....*....|....*....|....*....|....
gi 518546137 562 GGTGLGLAIAREMVQAHGGDIWADSIEGKGTTIT 595
Cdd:cd16940 77 GGSGLGLSIVKRIVELHGGQIFLGNAQGGGLEAW 110
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
373-602 |
7.06e-20 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 92.67 E-value: 7.06e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 373 MDQERREFVANVSHELRTPLTTMR----------SYLealAEGAweNKDIaprflmvtqnetERMIRLVNDLLQLSKFDS 442
Cdd:PRK09467 225 LEDDRTLLMAGVSHDLRTPLTRIRlatemmseedGYL---AESI--NKDI------------EECNAIIEQFIDYLRTGQ 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 443 KDyqfNREWIQIVRFISLIIDRfEMTKEQHVEFirNLPDRNLYVEIDQDKITQVLDNIISNALKYspegGHVTFSIDVNE 522
Cdd:PRK09467 288 EM---PMEMADLNALLGEVIAA-ESGYEREIET--ALQPGPIEVPMNPIAIKRALANLVVNAARY----GNGWIKVSSGT 357
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 523 EEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKlgGTGLGLAIAREMVQAHGGDI-WADSIEGkGTTITFTLPYK 601
Cdd:PRK09467 358 EGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARGSS--GTGLGLAIVKRIVDQHNGKVeLGNSEEG-GLSARAWLPLT 434
|
.
gi 518546137 602 E 602
Cdd:PRK09467 435 T 435
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
369-601 |
3.70e-19 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 91.89 E-value: 3.70e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 369 EQEKMDQERREFVANVSHELRTPLTTMRSYLEALAEgawenKDIAPR---FLMVTQNETERMIRLVNDLLQLSKFD--SK 443
Cdd:PRK11466 436 EAEKASQAKSAFLAAMSHEIRTPLYGILGTAQLLAD-----NPALNAqrdDLRAITDSGESLLTILNDILDYSAIEagGK 510
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 444 DYQFNREWIQIVRFISLIIDRFE-MTKEQHVEFIRNLPDR-NLYVEIDQDKITQVLDNIISNALKYSpEGGHVTFSIDVN 521
Cdd:PRK11466 511 NVSVSDEPFEPRPLLESTLQLMSgRVKGRPIRLATDIADDlPTALMGDPRRIRQVITNLLSNALRFT-DEGSIVLRSRTD 589
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 522 EEEelLYISVKDEGIGIPKKDVEKVFDRFYRVDKARtrklGGTGLGLAIAREMVQAHGGDIWADSIEGKGTTITFTLPYK 601
Cdd:PRK11466 590 GEQ--WLVEVEDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPLR 663
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
379-599 |
5.59e-19 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 91.45 E-value: 5.59e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 379 EFVANVSHELRTPL----------------TTMRSYLealaegawenkdiaprflmvtqNETER----MIRLVNDLLQLS 438
Cdd:PRK11107 295 EFLANMSHELRTPLngvigftrqtlktpltPTQRDYL----------------------QTIERsannLLAIINDILDFS 352
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 439 KFDS-----KDYQFN-REWI-QIVRF-----------ISLIIDRfemtkeqhvefirNLPDrnlYVEIDQDKITQVLDNI 500
Cdd:PRK11107 353 KLEAgklvlENIPFSlRETLdEVVTLlahsahekgleLTLNIDP-------------DVPD---NVIGDPLRLQQIITNL 416
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 501 ISNALKYSPEGghvtfSIDVNEEEE-------LLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGLGLAIARE 573
Cdd:PRK11107 417 VGNAIKFTESG-----NIDILVELRalsntkvQLEVQIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQK 491
|
250 260
....*....|....*....|....*.
gi 518546137 574 MVQAHGGDIWADSIEGKGTTITFTLP 599
Cdd:PRK11107 492 LVNEMGGDISFHSQPNRGSTFWFHLP 517
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
370-579 |
6.54e-18 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 86.63 E-value: 6.54e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 370 QEKMDQERReFVANVSHELRTPLTTMRSYLEaLAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDyqfNR 449
Cdd:PRK10337 231 HAMMVRERR-FTSDAAHELRSPLAALKVQTE-VAQLSDDDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDSLD---NL 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 450 EWIQIVRFISL----IIDRFEMTKEQHVEFIRNLPDRNLYVEIDQDKITQVLDNIISNALKYSPEGGHVTFSIDVNEeee 525
Cdd:PRK10337 306 QDVAEIPLEDLlqsaVMDIYHTAQQAGIDVRLTLNAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNARN--- 382
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 518546137 526 llyISVKDEGIGIPKKDVEKVFDRFYR---VDKArtrklgGTGLGLAIAREMVQAHG 579
Cdd:PRK10337 383 ---FTVRDNGPGVTPEALARIGERFYRppgQEAT------GSGLGLSIVRRIAKLHG 430
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
495-599 |
8.94e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 79.15 E-value: 8.94e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 495 QVLDNIISNALKYSP-EGGHVTFSidVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYrVDKARTRKLG-GTGLGLAIAR 572
Cdd:cd16953 3 QVLRNLIGNAISFSPpDTGRITVS--AMPTGKMVTISVEDEGPGIPQEKLESIFDRFY-TERPANEAFGqHSGLGLSISR 79
|
90 100 110
....*....|....*....|....*....|.
gi 518546137 573 EMVQAHGGDIWADSIE----GKGTTITFTLP 599
Cdd:cd16953 80 QIIEAHGGISVAENHNqpgqVIGARFTVQLP 110
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-599 |
1.64e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 78.26 E-value: 1.64e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 493 ITQVLDNIISNALKYSpeGGHVTFSIDVNEEeeLLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTrkLGGTGLGLAIAR 572
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGN--RTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQ 74
|
90 100
....*....|....*....|....*..
gi 518546137 573 EMVQAHGGDIWADSIEGKGTTITFTLP 599
Cdd:cd16950 75 RISDAHGGSLTLANRAGGGLCARIELP 101
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
140-589 |
2.55e-17 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 85.51 E-value: 2.55e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 140 PKSKIRVL---ISAKPVMTENQEVVGAI------YVVASMEDV--FNQ-----MKTINTILASGTGLALVLTALLGIFLA 203
Cdd:COG4192 268 PSLRRDELaaqATLEALAEENNSILEQLrtqisgLVGNSREQLvaLNQetaqlVQQSGILLLAIALLSLLLAVLINYFYV 347
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 204 -RTITHPLSDMRKQAMELAKGNFSRKVKKYGHDEIGQLATTFNHLTRELE--DAQAMTEGERRKLASviaymtdgviatn 280
Cdd:COG4192 348 rRRLVKRLNALSDAMAAIAAGDLDVPIPVDGNDEIGRIARLLRVFRDQAIekTQELETEIEERKRIE------------- 414
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 281 rngaiillnspalellnvsretalempitsllgiqenytfEDLVEQQDsmlleierddELtvlrvnfsvIQREHGKIDGl 360
Cdd:COG4192 415 ----------------------------------------KNLRQTQD----------EL---------IQAAKMAVVG- 434
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 361 iaviydvteqekmdqerrEFVANVSHELRTPLTTMRSYL-EALAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSK 439
Cdd:COG4192 435 ------------------QTMTSLAHELNQPLNAMSMYLfSAKKALEQENYAQLPTSLDKIEGLIERMDKIIKSLRQFSR 496
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 440 FDSKDYQFnrewiqiVRFISLIIDRFEMTKEQH--VEFIRNLPDrNLYVEIDQDKITQVLDNIISNALKYSPEGGHVtfS 517
Cdd:COG4192 497 KSDTPLQP-------VDLRQVIEQAWELVESRAkpQQITLHIPD-DLMVQGDQVLLEQVLVNLLVNALDAVATQPQI--S 566
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 518546137 518 IDVNEEEELLYISVKDEGIGIPkkDVEKVFDRFYrvdkarTRKLGGTGLGLAIAREMVQAHGGDIW-ADSIEG 589
Cdd:COG4192 567 VDLLSNAENLRVAISDNGNGWP--LVDKLFTPFT------TTKEVGLGLGLSICRSIMQQFGGDLYlASTLER 631
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
374-439 |
2.75e-17 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 76.10 E-value: 2.75e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518546137 374 DQERREFVANVSHELRTPLTTMRSYLEALAEGAWENKDIApRFLMVTQNETERMIRLVNDLLQLSK 439
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQR-EYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
495-582 |
4.18e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 77.12 E-value: 4.18e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 495 QVLDNIISNALKYSPEGGHVTFSIDVNEEEelLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKlGGTGLGLAIAREM 574
Cdd:cd16945 7 QAINNLLDNAIDFSPEGGLIALQLEADTEG--IELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQ-KSTGLGLAFVQEV 83
|
....*...
gi 518546137 575 VQAHGGDI 582
Cdd:cd16945 84 AQLHGGRI 91
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
376-442 |
5.70e-17 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 75.33 E-value: 5.70e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518546137 376 ERREFVANVSHELRTPLTTMRSYLEALAEgaWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDS 442
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRD--EKLDEEQREYLETILRSAERLLRLINDLLDLSRIEA 65
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
369-605 |
2.89e-16 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 82.42 E-value: 2.89e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 369 EQEKMDQERR-----------EFVANVSHELRTPLTTMRSYLEaLAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQL 437
Cdd:PRK13837 431 ETERDALERRleharrleavgTLASGIAHNFNNILGAILGYAE-MALNKLARHSRAARYIDEIISAGARARLIIDQILAF 509
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 438 SKfdSKDYqfNREWIQIVRFISLIIDRFEMTKEQHVEFIRNLPDRNLYVEIDQDKITQVLDNIISNALKYSPEGGHVTFS 517
Cdd:PRK13837 510 GR--KGER--NTKPFDLSELVTEIAPLLRVSLPPGVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDIS 585
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 518 IDVNE-------------EEELLYISVKDEGIGIPKKDVEKVFDRFYrvdkarTRKLGGTGLGLAIAREMVQAHGGDIWA 584
Cdd:PRK13837 586 LSRAKlrapkvlshgvlpPGRYVLLRVSDTGAGIDEAVLPHIFEPFF------TTRAGGTGLGLATVHGIVSAHAGYIDV 659
|
250 260
....*....|....*....|.
gi 518546137 585 DSIEGKGTTITFTLPYKEEQE 605
Cdd:PRK13837 660 QSTVGRGTRFDVYLPPSSKVP 680
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
376-442 |
5.70e-16 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 72.60 E-value: 5.70e-16
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518546137 376 ERREFVANVSHELRTPLTTMRSYLEALAEGAWENKDiaPRFLMVTQNETERMIRLVNDLLQLSKFDS 442
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQ--REYLETILREAERLLRLINDLLDLSRIEA 65
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
152-606 |
3.57e-14 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 75.33 E-value: 3.57e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 152 PVMTENQEVVGAIYVVASMEDVFNQMKTINTILASGTGLALVLTALLGIFLARTIthplsdmrKQAMelakgnfsrkvkk 231
Cdd:PRK11086 150 PVYDENGKQIGVVAVGISLSEVTEQINESRWSIYWSILFGALVGLIGTVILVRVL--------KRIL------------- 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 232 YGHD--EIGQLattfnhltreLEDAQAMtegerrkLASVIaymtDGVIATNRNGAIILLNSPALELLNVsRETALEMPIT 309
Cdd:PRK11086 209 FGLEpyEISTL----------FEQRQAM-------LQSIK----EGVIAVDDRGEVTLINDEAKRLFNY-KKGLEDDPLG 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 310 SLL-GIQENYTFEDLVEQQdsmllEIERDDELTV----LRVNfSVIQREHGKIDGLIAVIYDVTEQEKMDQErrefvanv 384
Cdd:PRK11086 267 TDVeSWMPVSRLKEVLRTG-----TPRRDEEINIngrlLLTN-TVPVRVNGEIIGAIATFRDKTEVRQLAQR-------- 332
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 385 shelrtpLTTMRSYLEALAEGAWE--NKdiaprflmvtqnetermIRLVNDLLQLSKFDS-KDY------QFNREWIQIV 455
Cdd:PRK11086 333 -------LDGMVNYADALRAQSHEfmNK-----------------LHVILGLLHLKSYDQlEDYilktanNYQEEIGSLL 388
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 456 RFI-SLIIDRFEMTK-----EQHVEFIRN----LPDrNLYVEIDQDKITqVLDNIISNALKY--SPEGGHVTFSIDVNEE 523
Cdd:PRK11086 389 GKIkSPVIAGFLLGKisrarELGITLIISedsqLPD-SGDEDQVHELIT-ILGNLIENALEAvgGEEGGEISVSLHYRNG 466
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 524 EelLYISVKDEGIGIPKKDVEKVFDRFYrvdkarTRKLGGTGLGLAIAREMVQAHGGDIWADSIEGKGTTITFTLPYKEE 603
Cdd:PRK11086 467 W--LHCEVSDDGPGIAPDEIDAIFDKGY------STKGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIPWDGE 538
|
...
gi 518546137 604 QED 606
Cdd:PRK11086 539 RSN 541
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
275-601 |
5.22e-14 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 73.58 E-value: 5.22e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 275 GVIATNRNGAIILL---------NSPALELLNVSRETALEMPITSLLG------------IQENYTFED-----LVEQQD 328
Cdd:PRK11073 10 GQILNSLINSILLLdddlaihyaNPAAQQLLAQSSRKLFGTPLPELLSyfslnielmresLQAGQGFTDnevtlVIDGRS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 329 SMLleierddELTVLRVNFSVIQREHGKIDgliaviydvtEQEKMDQER---------REFVANVSHELRTPLTTMRSYL 399
Cdd:PRK11073 90 HIL-------SLTAQRLPEGMILLEMAPMD----------NQRRLSQEQlqhaqqvaaRDLVRGLAHEIKNPLGGLRGAA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 400 EALAEGAWEnkdiaPRFLMVTQ---NETERMIRLVNDLLQLSKFDSKDYQFNREWIQIVRfiSLIidrfEMTKEQHVEFI 476
Cdd:PRK11073 153 QLLSKALPD-----PALTEYTKviiEQADRLRNLVDRLLGPQRPGTHVTESIHKVAERVV--QLV----SLELPDNVRLI 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 477 RN----LPDrnlyVEIDQDKITQVLDNIISNALK-YSPEGGHVT------FSIDVNEEEELLY--ISVKDEGIGIPKKDV 543
Cdd:PRK11073 222 RDydpsLPE----LAHDPDQIEQVLLNIVRNALQaLGPEGGTITlrtrtaFQLTLHGERYRLAarIDIEDNGPGIPPHLQ 297
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 518546137 544 EKVFdrfYRVDKARTrklGGTGLGLAIAREMVQAHGGDIWADSIEGKgTTITFTLPYK 601
Cdd:PRK11073 298 DTLF---YPMVSGRE---GGTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLPIR 348
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
470-582 |
7.28e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 68.81 E-value: 7.28e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 470 EQHVEFIRNLPDrNLYVEIDQDKITQVLDNIISNALKYSPEggHVTFSIDVNEEEelLYISVKDEGIGIPKKDVEKVFDR 549
Cdd:cd16954 16 RKGVSISLDISP-ELRFPGERNDLMELLGNLLDNACKWCLE--FVEVTARQTDGG--LHLIVDDDGPGVPESQRSKIFQR 90
|
90 100 110
....*....|....*....|....*....|...
gi 518546137 550 FYRVDKARTrklgGTGLGLAIAREMVQAHGGDI 582
Cdd:cd16954 91 GQRLDEQRP----GQGLGLAIAKEIVEQYGGEL 119
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
495-599 |
1.47e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 64.32 E-value: 1.47e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 495 QVLDNIISNALKYSPEGGHVTFSID---VNEEEELLY----------ISVKDEGIGIPKKDVEKVFDRFYRvdkarTRKL 561
Cdd:cd16919 3 LAILNLAVNARDAMPEGGRLTIETSnqrVDADYALNYrdlipgnyvcLEVSDTGSGMPAEVLRRAFEPFFT-----TKEV 77
|
90 100 110
....*....|....*....|....*....|....*....
gi 518546137 562 G-GTGLGLAIAREMVQAHGGDIWADSIEGKGTTITFTLP 599
Cdd:cd16919 78 GkGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-598 |
4.96e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 62.47 E-value: 4.96e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 493 ITQVLDNIISNALKYSPEGGHVTFSIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRvdkarTRKLG-GTGLGLAIA 571
Cdd:cd16976 1 IQQVLMNLLQNALDAMGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFT-----TKPVGkGTGLGLSIS 75
|
90 100
....*....|....*....|....*..
gi 518546137 572 REMVQAHGGDIWADSIEGKGTTITFTL 598
Cdd:cd16976 76 YGIVEEHGGRLSVANEEGAGARFTFDL 102
|
|
| HAMP |
pfam00672 |
HAMP domain; |
201-253 |
1.35e-11 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 59.56 E-value: 1.35e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 518546137 201 FLARTITHPLSDMRKQAMELAKGNFSRKVKKYGHDEIGQLATTFNHLTRELED 253
Cdd:pfam00672 1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
183-477 |
1.40e-11 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 66.83 E-value: 1.40e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 183 ILASGTGLALVLTALLGIFLARTITHPLSDMRKQAMELAKGNFSRKVKKYGHDEIGQLATTFNHLTRELEDAQAMTEGER 262
Cdd:COG3850 119 LALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFNRMADELQELYAELEEEE 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 263 RKLAsvIAYMTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLGIQENYTFEDLVEQQDSMLLEIERDDELTV 342
Cdd:COG3850 199 ELEA--ELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELLALNILAGLLELLLALLLLLLAS 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 343 LRVNFSVIQREHGKIDGLIAVIYDVTEQEKMDQERREFVANVSHELRTPLTTMRSYLEALAEGAWENKDIAPRFLMVTQN 422
Cdd:COG3850 277 ALLLLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQAIANASLLLIALASVVAALLELASILALQAALEAA 356
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 518546137 423 ETERMIRLVNDLLQLSKFDSKDYQFNREWIQIVRFISLIIDRFEMTKEQHVEFIR 477
Cdd:COG3850 357 AAGAALAAAAAAAGLARALAQAGADAAEALGLLAEASEGAAGQGAGLVDVEGGVA 411
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
207-251 |
2.73e-11 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 58.61 E-value: 2.73e-11
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 518546137 207 THPLSDMRKQAMELAKGNFSRKVKKYGHDEIGQLATTFNHLTREL 251
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
204-256 |
3.49e-11 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 58.41 E-value: 3.49e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 518546137 204 RTITHPLSDMRKQAMELAKGNFSRKVKKYGHDEIGQLATTFNHLTRELEDAQA 256
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
489-582 |
9.81e-11 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 64.27 E-value: 9.81e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 489 DQDKITQVLDNIISNALKYSPEgghvtF-SIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTrklgGTGLG 567
Cdd:PRK10815 375 EKNDFMEVMGNVLDNACKYCLE-----FvEISARQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRP----GQGLG 445
|
90
....*....|....*
gi 518546137 568 LAIAREMVQAHGGDI 582
Cdd:PRK10815 446 LSVAREITEQYEGKI 460
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
489-599 |
1.96e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 58.32 E-value: 1.96e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 489 DQDKITQVLDNIISNALKySPEG-----GHVTFSIDVNEEEELLyISVKDEGIGIPKKDVEKVFDRFYrvdkarTRKLGG 563
Cdd:cd16944 1 DTTQISQVLTNILKNAAE-AIEGrpsdvGEVRIRVEADQDGRIV-LIVCDNGKGFPREMRHRATEPYV------TTRPKG 72
|
90 100 110
....*....|....*....|....*....|....*.
gi 518546137 564 TGLGLAIAREMVQAHGGDIWADSIEGKGTTITFTLP 599
Cdd:cd16944 73 TGLGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
487-607 |
2.65e-10 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 63.15 E-value: 2.65e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 487 EIDQDKITQVLDNIISNALKYSPEGGHVTFS---IDVNEEEELLY----------ISVKDEGIGIPKKDVEKVFDRFYRv 553
Cdd:PRK13557 272 RIDPTQAEVALLNVLINARDAMPEGGRVTIRtrnVEIEDEDLAMYhglppgryvsIAVTDTGSGMPPEILARVMDPFFT- 350
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 518546137 554 dkarTRKLG-GTGLGLAIAREMVQAHGGDIWADSIEGKGTTITFTLPYKEEQEDD 607
Cdd:PRK13557 351 ----TKEEGkGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFPASDQAENP 401
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
7-479 |
2.87e-10 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 63.21 E-value: 2.87e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 7 FRSIQFKITLIYVLLIIIAMQIIGVYFVNQVEKSLISSYEQSLNQRIDNLSYYIEQEYKSDNDSTVIKDDVSRILNDFTK 86
Cdd:COG2770 41 LLLLLLLALLLLLLLLLLLLLAALVLLALLLAAALLLLLLLLSLVALAALLLALLLLLLLALLLLLAALLLLLLLAALAL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 87 SDEVREISFVDKSYEVVGSSKPYGEEVAGKQTTDLIFKRIFSTKQSYLRKYYDPKSKIRVLISAKPVMTENQEVVGAIYV 166
Cdd:COG2770 121 LLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAALALALGAGELLLLADLAAAIAALLAALLLLLLGGLLL 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 167 VASMEDVFNQMKTINTIlasgTGLALVLTALLGIFLARTITHPLSDMRKQAMELAKGNFSRKVKKYGHDEIGQLATTFNH 246
Cdd:COG2770 201 VVLLEAALAALLLLLLL----ALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNR 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 247 LTRELEDAQAMTEGERRKLASVIAYMTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLGIQENYTFEDLVEQ 326
Cdd:COG2770 277 MADSLRESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALAL 356
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 327 QDSMLLEIERDDELTVLRVNFSVIQREHGKIDGLIAVIYDVTEQEKMDQERREFVANVSHELRTPLTTMRSYLEALAEGA 406
Cdd:COG2770 357 AALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAA 436
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 518546137 407 WENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNREWIQIVRFISLIIDRFEMTKEQHVEFIRNL 479
Cdd:COG2770 437 ALELAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALELLLLEEEEEAGAAAEELAEEL 509
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
1-253 |
6.09e-10 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 61.96 E-value: 6.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 1 MNKVGFFRSIQFKITLIYVLLIIIAMQIIGVYFVNQVEKSLISSYEQSLNQRIDNLSYYIEQEYKSDNDSTVIKDDVSRI 80
Cdd:COG0840 3 ILLLLLALLLALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 81 LNDFTKSDEVREISFVDKSYEVVGSSKPYGEEVAGKQTTDLIFKRIFSTKQSYLRKYYDPKSKIRVLISAKPVMTENQEV 160
Cdd:COG0840 83 ALLLALLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 161 VGAIYVVASMEDVFNQMktINTILASGTGLALVLTALLGIFLARTITHPLSDMRKQAMELAKGNFSRKVKKYGHDEIGQL 240
Cdd:COG0840 163 LAALLEAAALALAAAAL--ALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQL 240
|
250
....*....|...
gi 518546137 241 ATTFNHLTRELED 253
Cdd:COG0840 241 ADAFNRMIENLRE 253
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
501-599 |
6.69e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 56.02 E-value: 6.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 501 ISNALKYSPeGGHVTFSIDVNEEEELLYisVKDEGIGIPKKDVEkvfdrfyrvdkartrklGGTGLGLAIAREMVQAHGG 580
Cdd:cd16917 9 LTNALKHAG-ASRVRVTLSYTADELTLT--VVDDGVGFDGPAPP-----------------GGGGFGLLGMRERAELLGG 68
|
90
....*....|....*....
gi 518546137 581 DIWADSIEGKGTTITFTLP 599
Cdd:cd16917 69 TLTIGSRPGGGTRVTARLP 87
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
496-599 |
8.17e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 56.14 E-value: 8.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 496 VLDNIISNALKYS----PEGGHVTFSIdvNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRvdkarTRKLGGTGLGLAIA 571
Cdd:cd16915 4 IVGNLIDNALDALaatgAPNKQVEVFL--RDEGDDLVIEVRDTGPGIAPELRDKVFERGVS-----TKGQGERGIGLALV 76
|
90 100
....*....|....*....|....*...
gi 518546137 572 REMVQAHGGDIWADSIEGKGTTITFTLP 599
Cdd:cd16915 77 RQSVERLGGSITVESEPGGGTTFSIRIP 104
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-599 |
1.17e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 55.87 E-value: 1.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 493 ITQVLDNIISNALK-YSPEGGHVTFSIDVNEEEEL--------LYISVKDEGIGIPKKDVEKVFDRFYrvdkarTRKLGG 563
Cdd:cd16918 1 LIQVFLNLVRNAAQaLAGSGGEIILRTRTQRQVTLghprhrlaLRVSVIDNGPGIPPDLQDTIFYPMV------SGRENG 74
|
90 100 110
....*....|....*....|....*....|....*.
gi 518546137 564 TGLGLAIAREMVQAHGGDIWADSIEGKgTTITFTLP 599
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
254-441 |
1.58e-09 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 58.88 E-value: 1.58e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 254 AQAMTEGERRKLASVIAYMTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLGIQENYTF----EDLVEQQDS 329
Cdd:COG2202 2 AEEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLPPEDDDEFlellRAALAGGGV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 330 MLLEIE---RDDELTVLRVNFSVIQREHGKIDGLIAVIYDVTEQEKMDQERREfvanvSHELrtplttMRSYLEALAEGA 406
Cdd:COG2202 82 WRGELRnrrKDGSLFWVELSISPVRDEDGEITGFVGIARDITERKRAEEALRE-----SEER------LRLLVENAPDGI 150
|
170 180 190
....*....|....*....|....*....|....*
gi 518546137 407 WENkDIAPRFLMVTQNETERMIRLVNDLLQLSKFD 441
Cdd:COG2202 151 FVL-DLDGRILYVNPAAEELLGYSPEELLGKSLLD 184
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
501-603 |
1.63e-09 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 58.86 E-value: 1.63e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 501 ISNALKYSPeGGHVTFSIDVNEEEelLYISVKDEGIGIPkkdvekvfdrfyrvdkarTRKLGGTGLGLAIAREMVQAHGG 580
Cdd:COG4585 171 LTNALKHAG-ATRVTVTLEVDDGE--LTLTVRDDGVGFD------------------PEAAPGGGLGLRGMRERAEALGG 229
|
90 100
....*....|....*....|...
gi 518546137 581 DIWADSIEGKGTTITFTLPYKEE 603
Cdd:COG4585 230 TLTIGSAPGGGTRVRATLPLAAA 252
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
497-603 |
1.95e-09 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 60.03 E-value: 1.95e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 497 LDNIISNALKYSPEGGHVTfsIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFyrvdkarTRKLGGTGLGLAIAREMVQ 576
Cdd:COG2972 345 VENAIEHGIEPKEGGGTIR--ISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-------SSKGEGRGIGLRNVRERLK 415
|
90 100 110
....*....|....*....|....*....|
gi 518546137 577 AHGGD---IWADSIEGKGTTITFTLPYKEE 603
Cdd:COG2972 416 LYYGEeygLEIESEPGEGTTVTIRIPLEEE 445
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
262-379 |
2.18e-09 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 59.78 E-value: 2.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 262 RRKLASVIAYMTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLgiqENYTFEDLVEQQDSMLLEIER-DDEL 340
Cdd:COG3829 10 EEELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVTELI---PNSPLLEVLKTGKPVTGVIQKtGGKG 86
|
90 100 110
....*....|....*....|....*....|....*....
gi 518546137 341 TVLRVNFSVIqREHGKIDGLIAVIYDVTEQEKMDQERRE 379
Cdd:COG3829 87 KTVIVTAIPI-FEDGEVIGAVETFRDITELKRLERKLRE 124
|
|
| dCache_1 |
pfam02743 |
Cache domain; Double cache domain 1 covers the last three strands from the membrane distal ... |
34-216 |
1.04e-06 |
|
Cache domain; Double cache domain 1 covers the last three strands from the membrane distal PAS-like domain, the first two strands of the membrane proximal domain, and the connecting elements between the two domains. This domain when present in chemoreceptors recognize several signals such as proteinogenic amino acids, GABA, Histamine and polyamines, decanoic acid, Autoinducer-2, purine derivatives, quaternary amines, citrate and taurine, among others. When associated with histidine kinases, it recognizes C3/C4-dicarboxylic acids, Spermine, guanosine and Autoinducer-2 (Mantilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1 https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 460673 [Multi-domain] Cd Length: 237 Bit Score: 50.03 E-value: 1.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 34 VNQVEKSLISSYEQSLNQRIDNLSYYIEQEYKSDNDSTVIKDDVSRILNDFTKSDEVREISFVDKSYEVVGSSKPYGEEV 113
Cdd:pfam02743 11 LLSLAKQLAENIESYLDSLEEILELLASNPDLQDLLSAPAEEELAKLESLLRSNPGISSIYLVDADGRVLASSDESPSYP 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 114 AGKQTTDLIFKRIFSTKQS----YLRKYYDPKSKIRVLISAKPVMTENQEVVGAIYVVASMEDVFNQMKTINTilaSGTG 189
Cdd:pfam02743 91 GLDVSERPWYKEALKGGGGiiwvFSSPYPSSESGEPVLTIARPIYDDDGEVIGVLVADLDLDTLQELLSQIKL---GEGG 167
|
170 180
....*....|....*....|....*..
gi 518546137 190 LALVLTAlLGIFLARTITHPLSDMRKQ 216
Cdd:pfam02743 168 YVFIVDS-DGRILAHPLGKNLRSLLAP 193
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
272-367 |
1.58e-06 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 46.86 E-value: 1.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 272 MTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLGIQENYTFEDLVEQ----QDSMLLEIE---RDDELTVLR 344
Cdd:cd00130 1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENllsgGEPVTLEVRlrrKDGSVIWVL 80
|
90 100
....*....|....*....|...
gi 518546137 345 VNFSVIQREHGKIDGLIAVIYDV 367
Cdd:cd00130 81 VSLTPIRDEGGEVIGLLGVVRDI 103
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
487-599 |
1.63e-06 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 47.60 E-value: 1.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 487 EIDQDKITQVLDNIISNALKYS-PEGGHVTFSIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRfyrvdkartrkLGGTG 565
Cdd:COG2172 29 EDDADDLVLAVSEAVTNAVRHAyGGDPDGPVEVELELDPDGLEIEVRDEGPGFDPEDLPDPYST-----------LAEGG 97
|
90 100 110
....*....|....*....|....*....|....*...
gi 518546137 566 LGLAIAREMvqahggdiwADSIE----GKGTTITFTLP 599
Cdd:COG2172 98 RGLFLIRRL---------MDEVEyesdPGGTTVRLVKR 126
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
240-605 |
2.41e-06 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 50.29 E-value: 2.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 240 LATTFNHLTRELEDAQAMTEGERRKLASVIAYMTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLGIQENYT 319
Cdd:COG3920 153 LAELAAALLLLAEELAALRLAAAALLLLLAALLDLGLALAALAAAALLALLLALELLLALLLLLLLLLALLLVLLAALLR 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 320 FEDLVEQQDSMLLEIERDDELTVLRVNFSVIQREHGKIDGLIAVIydVTEQEKMDQERREFVAN-------VSHELRTPL 392
Cdd:COG3920 233 LRAAVLEELERRRRARGLGRLLLLLLLLLLLLRALLLLAAGIRLV--ITERKRAEEELEASLEEkelllreLHHRVKNNL 310
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 393 TTMRSYLEALAEGAwENKDIApRFLMVTQNeteRM--IRLVNDLLqlskFDSKDYQFnrewIQIVRFISLIIDRF-EMTK 469
Cdd:COG3920 311 QVVSSLLRLQARRA-DDPEAR-EALEESQN---RIqaLALVHELL----YQSEDWEG----VDLRDYLRELLEPLrDSYG 377
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 470 EQHVEFIRNLPDrnlyVEIDQDKITQ---VLDNIISNALKY---SPEGGHVTfsIDVNEEEELLYISVKDEGIGIPKkdv 543
Cdd:COG3920 378 GRGIRIELDGPD----VELPADAAVPlglILNELVTNALKHaflSGEGGRIR--VSWRREDGRLRLTVSDNGVGLPE--- 448
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518546137 544 ekvfdrfyRVDKARTRklggtGLGLAIAREMVQAHGGDIwaDSIEGKGTTITFTLPYKEEQE 605
Cdd:COG3920 449 --------DVDPPARK-----GLGLRLIRALVRQLGGTL--ELDRPEGTRVRITFPLAELAA 495
|
|
| HATPase_ETR2_ERS2-EIN4-like |
cd16938 |
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related ... |
479-598 |
1.49e-05 |
|
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related domains; This family includes the histidine kinase-like ATPase domains (HATPase) of three out of the five receptors that recognize the plant hormone ethylene in Arabidopsis thaliana. These three proteins have been classified as belonging to subfamily 2: ETR2, ERS2, and EIN4. They lack most of the motifs characteristic of histidine kinases, and EIN4 is the only one in this group containing the conserved histidine that is phosphorylated in two-component and phosphorelay systems. This family also includes the HATPase domains of Escherichia coli RcsD phosphotransferase which is a component of the Rcs-signaling system, a complex multistep phosphorelay involving five proteins, and is involved in many transcriptional networks such as cell division, biofilm formation, and virulence, among others. Also included is Schizosaccharomyces pombe Mak3 (Phk1) which participates in a multi-step two-component related system which regulates H2O2-induced activation of the Sty1 stress-activated protein kinase pathway. Most proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a GAF sensor domain; most are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340415 [Multi-domain] Cd Length: 133 Bit Score: 44.76 E-value: 1.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 479 LPDrnlYVEIDQDKITQVLDNIISNALKYSPEGGHVTFSIDVneEEELLYISVKDEGIGIPKKDVEKVFDRF-YRV---- 553
Cdd:cd16938 1 LPD---VVVGDERRVFQVLLHMLGNLLKMRNGGGNITFRVFL--EGGSEDRSDRDWGPWRPSMSDESVEIRFeVEIndsg 75
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 518546137 554 ----DKARTRK---------LGGTGLGLAIAREMVQAHGGDIWADSIEGKGTTITFTL 598
Cdd:cd16938 76 spsiESASMRNslnrrynlsELGEHLSFSICKQLVQLMGGNIWIVPGSGLGTTMSLLL 133
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
249-377 |
2.34e-05 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 46.17 E-value: 2.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 249 RELEDAQAMTEgerRKLASVIAYMTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLGIQENYTFEDLVEQ-- 326
Cdd:COG2202 126 KRAEEALRESE---ERLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKSLLDLLHPEDRERLLELLRRll 202
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 518546137 327 -QDSMLLEIE---RDDELTVLRVNFSVIQREHG-KIDGLIAVIYDVTEQEKMDQER 377
Cdd:COG2202 203 eGGRESYELElrlKDGDGRWVWVEASAVPLRDGgEVIGVLGIVRDITERKRAEEAL 258
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
263-327 |
4.33e-05 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 41.62 E-value: 4.33e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 518546137 263 RKLASVIAYMTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLGIQENYTFEDLVEQQ 327
Cdd:smart00091 1 ERLRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHPEDRERVQEALQRL 65
|
|
| UhpB |
COG3851 |
Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction ... |
501-599 |
1.73e-04 |
|
Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction mechanisms];
Pssm-ID: 443060 [Multi-domain] Cd Length: 493 Bit Score: 44.61 E-value: 1.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 501 ISNALKYSpEGGHVtfSIDVNEEEELLYISVKDEGIGIPkkdvekvfdrfyrvdkARTRKlggTGLGLAIAREMVQAHGG 580
Cdd:COG3851 409 LTNILKHA-EASQI--RISLSQDKRLLSLEIRDDGIGLP----------------PELRA---KGFGLRGMRERVRALGG 466
|
90
....*....|....*....
gi 518546137 581 DiWADSIEGKGTTITFTLP 599
Cdd:COG3851 467 D-FRLSSAPKGTRLSVLLP 484
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
495-599 |
3.78e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 40.10 E-value: 3.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 495 QVL-DNIISNALKYSPEGGHVTFSidVNEEEELLYISVKDEGIGIPKkdvekvfDRFYRVDKARTRKLGGTGLGLA-IAR 572
Cdd:cd16957 7 QVLvENAIRHAFPKRKENNEVRVV--VKKDQHKVHVSVSDNGQGIPE-------ERLDLLGKTTVTSEKGTGTALEnLNR 77
|
90 100
....*....|....*....|....*....
gi 518546137 573 EMVQAHG--GDIWADSIEGKGTTITFTLP 599
Cdd:cd16957 78 RLIGLFGseACLHIESEVHGGTEVWFVIP 106
|
|
| HATPase_PDK-like |
cd16929 |
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ... |
518-599 |
3.98e-04 |
|
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.
Pssm-ID: 340406 [Multi-domain] Cd Length: 169 Bit Score: 41.56 E-value: 3.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 518 IDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFY-------------RVDKARTRKLGGTGLGLAIAREMVQAHGGDIWA 584
Cdd:cd16929 75 VTVAKGDEDLTIKISDRGGGIPREDLARLFSYMYstapqpslddfsdLISGTQPSPLAGFGYGLPMSRLYAEYFGGDLDL 154
|
90
....*....|....*
gi 518546137 585 DSIEGKGTTITFTLP 599
Cdd:cd16929 155 QSMEGYGTDVYIYLK 169
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
369-611 |
4.20e-04 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 43.38 E-value: 4.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 369 EQEKMDQERREFVANVSHELRTPLTTMRSYLEALAEGAWENKDIAPrfLMVTQNETERMIRLVNDLLQLSKFDSKDYQFN 448
Cdd:PRK10618 442 EYEKNQQARKAFLQNIGDELKQPLQSLAQLAAQLRQTSDEEQQQPE--LDQLAEQSDVLVRLVDNIQLLNMLETQDWKPE 519
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 449 REWIQIVRFI-SLIIDRFEMTKEQHVE-FIRNLPDRNLYVEIDQDkitqVLDNIISNALKYS---PEGGHVTFSIDV-NE 522
Cdd:PRK10618 520 QELFSLQDLIdEVLPEVLPAIKRKGLQlLIHNHLKAEQLRIGDRD----ALRKILLLLLNYAittTAYGKITLEVDQdES 595
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 523 EEELLYISVKDEGIGIPKKDV---------EKVFDRFYRvdkartrklgGTGLGLAIAREMVQAHGGDIWADSIEGKGTT 593
Cdd:PRK10618 596 SPDRLTIRILDTGAGVSIKELdnlhfpflnQTQGDRYGK----------ASGLTFFLCNQLCRKLGGHLTIKSREGLGTR 665
|
250
....*....|....*...
gi 518546137 594 ITFTLPYKEEQEDDWDET 611
Cdd:PRK10618 666 YSIHLKMLAADPEVEEEE 683
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
488-607 |
4.47e-04 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 43.28 E-value: 4.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 488 IDQDKITQVLDNIISNALKYS---PEGGHVTfSIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYrvdKARTRKLGGT 564
Cdd:PRK15053 428 LDSTEFAAIVGNLLDNAFEASlrsDEGNKIV-ELFLSDEGDDVVIEVADQGCGVPESLRDKIFEQGV---STRADEPGEH 503
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 518546137 565 GLGLAIAREMVQAHGGDIWADSIEGKGTTITFTLPyKEEQEDD 607
Cdd:PRK15053 504 GIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFIP-KVKPNDS 545
|
|
| PRK11644 |
PRK11644 |
signal transduction histidine-protein kinase/phosphatase UhpB; |
501-599 |
6.23e-04 |
|
signal transduction histidine-protein kinase/phosphatase UhpB;
Pssm-ID: 236945 [Multi-domain] Cd Length: 495 Bit Score: 42.66 E-value: 6.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 501 ISNALKYSpEGGHVTfsIDVNEEEELLYISVKDEGIGIPKKDVEKvfdrfyrvdkartrklggtGLGLAIAREMVQAHGG 580
Cdd:PRK11644 419 LNNIVKHA-DASAVT--LQGWQQDERLMLVIEDDGSGLPPGSGQQ-------------------GFGLRGMRERVTALGG 476
|
90
....*....|....*....
gi 518546137 581 DIWADSIEgkGTTITFTLP 599
Cdd:PRK11644 477 TLTISCTH--GTRLSVSLP 493
|
|
| HATPase_RsbT-like |
cd16934 |
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine ... |
487-595 |
7.82e-04 |
|
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.
Pssm-ID: 340411 [Multi-domain] Cd Length: 117 Bit Score: 39.66 E-value: 7.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 487 EIDQDKITQVLDNIISNALKYSpEGGHVTFSIDVNEEEELLYISVKDEGIGIPkkDVEKVF-DRFyrvdkartRKLGGTG 565
Cdd:cd16934 20 EVRQAEIATAVTELARNLLKHA-GGGQVLLEVVAEGGRVALEILAVDQGPGIA--DVDEALrDGF--------STGGGLG 88
|
90 100 110
....*....|....*....|....*....|
gi 518546137 566 LGLAIAREMvqAHGGDIwaDSIEGKGTTIT 595
Cdd:cd16934 89 LGLGGVRRL--ADEFDL--HSAPGRGTVVV 114
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
272-367 |
1.20e-03 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 38.94 E-value: 1.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 272 MTDGVIATNRNGAIILLNSPALELLNVSRETALEMPITSLLGIQENYTFEDLVEQ-----QDSMLLEIER---DDELTVL 343
Cdd:pfam00989 10 LPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIPEEDDAEVAELLRQallqgEESRGFEVSFrvpDGRPRHV 89
|
90 100
....*....|....*....|....
gi 518546137 344 RVNFSVIQREHGKIDGLIAVIYDV 367
Cdd:pfam00989 90 EVRASPVRDAGGEILGFLGVLRDI 113
|
|
| HATPase_YpdA-like |
cd16955 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-599 |
1.56e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340431 [Multi-domain] Cd Length: 102 Bit Score: 38.21 E-value: 1.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 493 ITQVLDNIISNALKYSPEGGHVTFSIDVNEEEELlYISVKDEGIGIPKKDVEKVfdrfyRVDKARTRKLG---------- 562
Cdd:cd16955 6 IQPLVENAIVHGIQEKKGKGVVKISVKKQLKNRL-HIAVEDNGIGISPKVIERV-----EQDEMPGNKIGllnvhqrlkl 79
|
90 100 110
....*....|....*....|....*....|....*..
gi 518546137 563 GTGLGLAIaremvqahggdiwaDSIEGKGTTITFTLP 599
Cdd:cd16955 80 GYGEGLHI--------------RSRPDPGTLIAFYIP 102
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
505-599 |
2.47e-03 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 40.94 E-value: 2.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 505 LKYSPEGGHVtfsidvneeeellYISVKDEGIGIpkkDVEKVfdrfyrVDKARTRKL---------------------G- 562
Cdd:COG0643 313 LSAYHEGGRV-------------VIEVSDDGRGL---DLEKI------RAKAIEKGLitaeeaaalsdeellelifapGf 370
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 518546137 563 ----------GTGLGLAIAREMVQAHGGDIWADSIEGKGTTITFTLP 599
Cdd:COG0643 371 staeevtdlsGRGVGMDVVKTNIEALGGTIEIESEPGKGTTFTLRLP 417
|
|
| PRK10935 |
PRK10935 |
nitrate/nitrite two-component system sensor histidine kinase NarQ; |
178-251 |
3.56e-03 |
|
nitrate/nitrite two-component system sensor histidine kinase NarQ;
Pssm-ID: 236800 [Multi-domain] Cd Length: 565 Bit Score: 40.22 E-value: 3.56e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 518546137 178 KTINTILASGTGLALVLT-ALLGI-FLARTITHPLSDMRKQAMELAKGNFSR---KVKKYghDEIGQLATTFNHLTREL 251
Cdd:PRK10935 146 KLILLAAISLLGLILILTlVFFTVrFTRRQVVAPLNQLVTASQQIEKGQFDHiplDTTLP--NELGLLAKAFNQMSSEL 222
|
|
| HATPase_EL346-LOV-HK-like |
cd16951 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
488-599 |
4.09e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.
Pssm-ID: 340427 [Multi-domain] Cd Length: 131 Bit Score: 37.78 E-value: 4.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518546137 488 IDQDKITQ---VLDNIISNALKYSPEGG-HVTFSIDVNEEEELLYISVKDEGIGIPKKDvekvfdrfyrvDKARTRKlgg 563
Cdd:cd16951 32 VSSEVATAiglVVNELLQNALKHAFSDReGGTITIRSVVDGDYLRITVIDDGVGLPQDE-----------DWPNKGS--- 97
|
90 100 110
....*....|....*....|....*....|....*.
gi 518546137 564 tgLGLAIAREMVQAHGGDIWADSIEGKGTTITFTLP 599
Cdd:cd16951 98 --LGLQIVRSLVEGELKAFLEVQSAENGTRVNIDIP 131
|
|
| |
