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Conserved domains on  [gi|518445234|ref|WP_019615441|]
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pyrimidine/purine nucleoside phosphorylase [Psychromonas ossibalaenae]

Protein Classification

pyrimidine/purine nucleoside phosphorylase( domain architecture ID 10536379)

pyrimidine/purine nucleoside phosphorylase catalyzes the phosphorolysis of diverse nucleosides, such as uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine, yielding D-ribose 1-phosphate and the respective free bases; also catalyzes the reverse reactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ppnp pfam06865
Pyrimidine/purine nucleoside phosphorylase; This family consist of YaiE and related proteins. ...
 3-93 4.12e-50

Pyrimidine/purine nucleoside phosphorylase; This family consist of YaiE and related proteins. YaiE from E. coli catalyzes phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and free bases.


:

Pssm-ID: 462023  Cd Length: 92  Bit Score: 153.02  E-value: 4.12e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518445234   3 FETNEYFDGNVQSIAFQSET-LPATVGVMEVGDYTFGTGAKEYMTVVSGNLTVKLPGEEKWKTFNAGETFEVEGNASFDV 81
Cdd:pfam06865  1 KKANVYFDGKVTSRTFEFADgSKKTLGVMLPGEYTFGTGAPEIMEVVSGELEVKLPGSDEWKTYAAGESFEVPANSSFDL 80

                         90
                 ....*....|..
gi 518445234  82 KVTVQTAYLCLY 93
Cdd:pfam06865 81 KVKEVTDYLCSY 92
 
Name Accession Description Interval E-value
Ppnp pfam06865
Pyrimidine/purine nucleoside phosphorylase; This family consist of YaiE and related proteins. ...
 3-93 4.12e-50

Pyrimidine/purine nucleoside phosphorylase; This family consist of YaiE and related proteins. YaiE from E. coli catalyzes phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and free bases.


Pssm-ID: 462023  Cd Length: 92  Bit Score: 153.02  E-value: 4.12e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518445234   3 FETNEYFDGNVQSIAFQSET-LPATVGVMEVGDYTFGTGAKEYMTVVSGNLTVKLPGEEKWKTFNAGETFEVEGNASFDV 81
Cdd:pfam06865  1 KKANVYFDGKVTSRTFEFADgSKKTLGVMLPGEYTFGTGAPEIMEVVSGELEVKLPGSDEWKTYAAGESFEVPANSSFDL 80

                         90
                 ....*....|..
gi 518445234  82 KVTVQTAYLCLY 93
Cdd:pfam06865 81 KVKEVTDYLCSY 92
PpnP COG3123
Pyrimidine/purine nucleoside phosphorylase YaiE/PpnP, UPF0345/DUF1255 family [Nucleotide ...
 1-91 3.18e-49

Pyrimidine/purine nucleoside phosphorylase YaiE/PpnP, UPF0345/DUF1255 family [Nucleotide transport and metabolism];


Pssm-ID: 442357  Cd Length: 99  Bit Score: 150.70  E-value: 3.18e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518445234  1 MSFETNEYFDGNVQSIAFQSET-LPATVGVMEVGDYTFGTGAKEYMTVVSGNLTVKLPGEEKWKTFNAGETFEVEGNASF 79
Cdd:COG3123   7 VMKKANVYFDGKVKSRTFIFADgSKKTLGVMLPGEYTFGTGAPEIMEVVSGELEVKLPGSDEWQTYAAGESFEVPANSSF 86

                        90
                ....*....|..
gi 518445234 80 DVKVTVQTAYLC 91
Cdd:COG3123  87 DLKVAEPTAYLC 98
cupin_PpnP-like cd20296
pyrimidine/purine nucleoside phosphorylase and related proteins, cupin domain; This family ...
 6-93 1.52e-37

pyrimidine/purine nucleoside phosphorylase and related proteins, cupin domain; This family includes cupin domain proteins that are homologous to pyrimidine/purine nucleoside phosphorylase PpnP. Purine and pyrimidine nucleoside phosphorylases are key enzymes of the nucleoside salvage pathway; they catalyze the reversible phosphorolytic cleavage of the glycosidic bond of purine and pyrimidine nucleosides. Nucleoside phosphorylases are of medical interest since phosphorylases can be used in activating prodrugs; high-molecular mass purine nucleoside phosphorylases may be used in gene therapy of some solid tumors and their inhibitors could be selective immunosuppressive, anticancer, and antiparasitic agents. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380430  Cd Length: 90  Bit Score: 121.14  E-value: 1.52e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518445234  6 NEYFDGNVQSIAFQSE-TLPATVGVMEVGDYTFGTGAKEYMTVVSGNLTVKLPGEEKWKTFNAGETFEVEGNASFDVKVT 84
Cdd:cd20296   2 NVYFDGKVKSRTVIFAdGSKKTLGVMLPGEYTFGTEAPERMEIISGECRVKLPGETDWQTYSAGESFEVPANSSFKIEVK 81


                ....*....
gi 518445234 85 VQTAYLCLY 93
Cdd:cd20296  82 EVTDYLCSY 90
PRK10579 PRK10579
pyrimidine/purine nucleoside phosphorylase;
6-93 1.02e-32

pyrimidine/purine nucleoside phosphorylase;


Pssm-ID: 182565  Cd Length: 94  Bit Score: 109.12  E-value: 1.02e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518445234  6 NEYFDGNVQSIAFQSETL-PATVGVMEVGDYTFGTGAKEYMTVVSGNLTVKLPGEEKWKTFNAGETFEVEGNASFDVKVT 84
Cdd:PRK10579  5 NEYFSGKVKSIGFDSSSTgRASVGVMAEGEYTFSTAEPEEMTVISGALNVLLPGATDWQVYEAGEVFNVPGHSEFHLQVA 84


                ....*....
gi 518445234 85 VQTAYLCLY 93
Cdd:PRK10579 85 EPTSYLCRY 93
 
Name Accession Description Interval E-value
Ppnp pfam06865
Pyrimidine/purine nucleoside phosphorylase; This family consist of YaiE and related proteins. ...
 3-93 4.12e-50

Pyrimidine/purine nucleoside phosphorylase; This family consist of YaiE and related proteins. YaiE from E. coli catalyzes phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and free bases.


Pssm-ID: 462023  Cd Length: 92  Bit Score: 153.02  E-value: 4.12e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518445234   3 FETNEYFDGNVQSIAFQSET-LPATVGVMEVGDYTFGTGAKEYMTVVSGNLTVKLPGEEKWKTFNAGETFEVEGNASFDV 81
Cdd:pfam06865  1 KKANVYFDGKVTSRTFEFADgSKKTLGVMLPGEYTFGTGAPEIMEVVSGELEVKLPGSDEWKTYAAGESFEVPANSSFDL 80

                         90
                 ....*....|..
gi 518445234  82 KVTVQTAYLCLY 93
Cdd:pfam06865 81 KVKEVTDYLCSY 92
PpnP COG3123
Pyrimidine/purine nucleoside phosphorylase YaiE/PpnP, UPF0345/DUF1255 family [Nucleotide ...
 1-91 3.18e-49

Pyrimidine/purine nucleoside phosphorylase YaiE/PpnP, UPF0345/DUF1255 family [Nucleotide transport and metabolism];


Pssm-ID: 442357  Cd Length: 99  Bit Score: 150.70  E-value: 3.18e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518445234  1 MSFETNEYFDGNVQSIAFQSET-LPATVGVMEVGDYTFGTGAKEYMTVVSGNLTVKLPGEEKWKTFNAGETFEVEGNASF 79
Cdd:COG3123   7 VMKKANVYFDGKVKSRTFIFADgSKKTLGVMLPGEYTFGTGAPEIMEVVSGELEVKLPGSDEWQTYAAGESFEVPANSSF 86

                        90
                ....*....|..
gi 518445234 80 DVKVTVQTAYLC 91
Cdd:COG3123  87 DLKVAEPTAYLC 98
cupin_PpnP-like cd20296
pyrimidine/purine nucleoside phosphorylase and related proteins, cupin domain; This family ...
 6-93 1.52e-37

pyrimidine/purine nucleoside phosphorylase and related proteins, cupin domain; This family includes cupin domain proteins that are homologous to pyrimidine/purine nucleoside phosphorylase PpnP. Purine and pyrimidine nucleoside phosphorylases are key enzymes of the nucleoside salvage pathway; they catalyze the reversible phosphorolytic cleavage of the glycosidic bond of purine and pyrimidine nucleosides. Nucleoside phosphorylases are of medical interest since phosphorylases can be used in activating prodrugs; high-molecular mass purine nucleoside phosphorylases may be used in gene therapy of some solid tumors and their inhibitors could be selective immunosuppressive, anticancer, and antiparasitic agents. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380430  Cd Length: 90  Bit Score: 121.14  E-value: 1.52e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518445234  6 NEYFDGNVQSIAFQSE-TLPATVGVMEVGDYTFGTGAKEYMTVVSGNLTVKLPGEEKWKTFNAGETFEVEGNASFDVKVT 84
Cdd:cd20296   2 NVYFDGKVKSRTVIFAdGSKKTLGVMLPGEYTFGTEAPERMEIISGECRVKLPGETDWQTYSAGESFEVPANSSFKIEVK 81


                ....*....
gi 518445234 85 VQTAYLCLY 93
Cdd:cd20296  82 EVTDYLCSY 90
PRK10579 PRK10579
pyrimidine/purine nucleoside phosphorylase;
6-93 1.02e-32

pyrimidine/purine nucleoside phosphorylase;


Pssm-ID: 182565  Cd Length: 94  Bit Score: 109.12  E-value: 1.02e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518445234  6 NEYFDGNVQSIAFQSETL-PATVGVMEVGDYTFGTGAKEYMTVVSGNLTVKLPGEEKWKTFNAGETFEVEGNASFDVKVT 84
Cdd:PRK10579  5 NEYFSGKVKSIGFDSSSTgRASVGVMAEGEYTFSTAEPEEMTVISGALNVLLPGATDWQVYEAGEVFNVPGHSEFHLQVA 84


                ....*....
gi 518445234 85 VQTAYLCLY 93
Cdd:PRK10579 85 EPTSYLCRY 93
cupin_Mj0764-like cd20290
uncharacterized Methanocaldococcus jannaschii Mj0764 and related proteins, cupin domain; This ...
 44-82 5.48e-03

uncharacterized Methanocaldococcus jannaschii Mj0764 and related proteins, cupin domain; This family includes archaeal and bacterial proteins homologous to MJ0764, a Methanocaldococcus jannaschii protein of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380424 [Multi-domain]  Cd Length: 100  Bit Score: 33.33  E-value: 5.48e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 518445234  44 YMTVVSGNLTVKLPGEEKwKTFNAGETFEVEGNASFDVK 82
Cdd:cd20290   46 YMTVVRGTLTLTLEDQET-HKYEAGTILKIPFNTKMNIK 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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