NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|518418553|ref|WP_019588760|]
View 

class II fructose-1,6-bisphosphate aldolase [Deinococcus apachensis]

Protein Classification

class II fructose-bisphosphate aldolase( domain architecture ID 10785082)

class II fructose-1,6-bisphosphate (FBP) aldolase catalyzes the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate

CATH:  3.20.20.70
EC:  4.1.2.13
Gene Ontology:  GO:0004332|GO:0006096|GO:0008270|GO:0030388
PubMed:  12206759|2199259|1412694
SCOP:  4003234

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Fba COG0191
Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose ...
 1-305 5.93e-150

Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose/tagatose bisphosphate aldolase is part of the Pathway/BioSystem: Glycolysis


:

Pssm-ID: 439961  Cd Length: 283  Bit Score: 421.42  E-value: 5.93e-150
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553   1 MLVTGNDILVPARAGKYAVGSFNTNNMEMTQAIIHTAERLRSPVMVQMSEGAIKYGGQD-LAHIVIDLAERASVPVALHL 79
Cdd:COG0191    1 MLVSLKELLDKAKEGGYAVPAFNVNNLETLQAILEAAEELNSPVILQVSEGAAKYAGLEyLAAMVRAAAEEASVPVALHL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553  80 DHGSSYESVLRAIKMGFTSVMIDASHHPFEENVHETRRVVEAAHAMGISVESELGRLGGIEEHIVVDEKDAFLTDPEEAV 159
Cdd:COG0191   81 DHGASFELIKRAIDAGFTSVMIDGSHLPFEENIAITKEVVEYAHAAGVSVEAELGVVGGEEDGVDVDDAEALYTDPEEAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553 160 QFVEQTGTDYLAIAIGTSHGAYKGKgrPFIDQARIERISQLVSIPLVAHGSSGVPaeivqrfrdaggeigdaagiaDEDL 239
Cdd:COG0191  161 EFVEETGVDALAVAIGTVHGVYKGE--PKLDFDRLKEIREAVPVPLVLHGGSGVP---------------------DEEI 217

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518418553 240 QQAAQHGIAKVNVDTDLRLALTVAVREVLQKTPKEFDPRKLFGPARDLMSQIIEHKMRVLGSVGQA 305
Cdd:COG0191  218 REAIKLGVAKINIDTDLRLAFTAAVREYLAENPDKYDPRKYLKPAREAMKEVVKEKIRLFGSAGKA 283
 
Name Accession Description Interval E-value
Fba COG0191
Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose ...
 1-305 5.93e-150

Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose/tagatose bisphosphate aldolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439961  Cd Length: 283  Bit Score: 421.42  E-value: 5.93e-150
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553   1 MLVTGNDILVPARAGKYAVGSFNTNNMEMTQAIIHTAERLRSPVMVQMSEGAIKYGGQD-LAHIVIDLAERASVPVALHL 79
Cdd:COG0191    1 MLVSLKELLDKAKEGGYAVPAFNVNNLETLQAILEAAEELNSPVILQVSEGAAKYAGLEyLAAMVRAAAEEASVPVALHL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553  80 DHGSSYESVLRAIKMGFTSVMIDASHHPFEENVHETRRVVEAAHAMGISVESELGRLGGIEEHIVVDEKDAFLTDPEEAV 159
Cdd:COG0191   81 DHGASFELIKRAIDAGFTSVMIDGSHLPFEENIAITKEVVEYAHAAGVSVEAELGVVGGEEDGVDVDDAEALYTDPEEAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553 160 QFVEQTGTDYLAIAIGTSHGAYKGKgrPFIDQARIERISQLVSIPLVAHGSSGVPaeivqrfrdaggeigdaagiaDEDL 239
Cdd:COG0191  161 EFVEETGVDALAVAIGTVHGVYKGE--PKLDFDRLKEIREAVPVPLVLHGGSGVP---------------------DEEI 217

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518418553 240 QQAAQHGIAKVNVDTDLRLALTVAVREVLQKTPKEFDPRKLFGPARDLMSQIIEHKMRVLGSVGQA 305
Cdd:COG0191  218 REAIKLGVAKINIDTDLRLAFTAAVREYLAENPDKYDPRKYLKPAREAMKEVVKEKIRLFGSAGKA 283
fruc_bis_ald_ TIGR01859
fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; ...
 2-305 8.26e-149

fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; This model represents of one of several subtypes of the class II fructose-1,6-bisphosphate aldolase, an enzyme of glycolysis. The subtypes are split into several models to allow separation of a family of tagatose bisphosphate aldolases. This form is found in Gram-positive bacteria, a variety of Gram-negative, and in amitochondriate protists. The class II enzymes share homology with tagatose bisphosphate aldolase but not with class I aldolase. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 130918  Cd Length: 282  Bit Score: 418.69  E-value: 8.26e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553    2 LVTGNDILVPARAGKYAVGSFNTNNMEMTQAIIHTAERLRSPVMVQMSEGAIKYGG--QDLAHIVIDLAERAS-VPVALH 78
Cdd:TIGR01859   1 LVNGKEILQKAKKEGYAVGAFNFNNLEWTQAILEAAEEENSPVIIQVSEGAIKYMGgyKMAVAMVKTLIERMSiVPVALH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553   79 LDHGSSYESVLRAIKMGFTSVMIDASHHPFEENVHETRRVVEAAHAMGISVESELGRLGGIEEHivVDEKDAFLTDPEEA 158
Cdd:TIGR01859  81 LDHGSSYESCIKAIKAGFSSVMIDGSHLPFEENLALTKKVVEIAHAKGVSVEAELGTLGGIEDG--VDEKEAELADPDEA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553  159 VQFVEQTGTDYLAIAIGTSHGAYkgKGRPFIDQARIERISQLVSIPLVAHGSSGVPaeivqrfrdaggeigdaagiaDED 238
Cdd:TIGR01859 159 EQFVKETGVDYLAAAIGTSHGKY--KGEPGLDFERLKEIKELTNIPLVLHGASGIP---------------------EEQ 215

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518418553  239 LQQAAQHGIAKVNVDTDLRLALTVAVREVLQKTPKEFDPRKLFGPARDLMSQIIEHKMRVLGSVGQA 305
Cdd:TIGR01859 216 IKKAIKLGIAKINIDTDCRIAFTAAIRKVLTEKKDEYDPRKILGPAREAIKETVKEKMRLFGSAGKA 282
F_bP_aldolase pfam01116
Fructose-bisphosphate aldolase class-II;
3-304 2.26e-137

Fructose-bisphosphate aldolase class-II;


Pssm-ID: 460071  Cd Length: 276  Bit Score: 389.46  E-value: 2.26e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553    3 VTGNDILVPARAGKYAVGSFNTNNMEMTQAIIHTAERLRSPVMVQMSEGAIKY---GGQDLAHIVIDLAERASVPVALHL 79
Cdd:pfam01116   1 VNLKELLKKAKEGGYAVPAFNVNNLETVQAILEAAEEAKSPVILQVSPGAAAKyagGAEALAALVRAAAEAAGVPVALHL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553   80 DHGSSYESVLRAIKMGFTSVMIDASHHPFEENVHETRRVVEAAHAMGISVESELGRLGGIEEHIVVDEKdaFLTDPEEAV 159
Cdd:pfam01116  81 DHGASFELIKEAIEAGFTSVMIDGSHLPFEENIAITKEVVEYAHARGVSVEAELGRIGGEEDGVVVDEK--LYTDPEEAA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553  160 QFVEQTGTDYLAIAIGTSHGAYKGKGRpfIDQARIERISQLVSIPLVAHGSSGVPaeivqrfrdaggeigdaagiaDEDL 239
Cdd:pfam01116 159 EFVEATGVDALAVAIGNVHGVYKPGPK--LDFDRLKEIQEAVPVPLVLHGGSGVP---------------------DEDI 215

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 518418553  240 QQAAQHGIAKVNVDTDLRLALTVAVREVlqktPKEFDPRKLFGPARDLMSQIIEHKMRVLGSVGQ 304
Cdd:pfam01116 216 RKAIKLGVCKINIDTDLQLAFTAAVREY----PPNKDPRKYLRPAEEAMKEVVKEKIRLFGSAGK 276
PRK12857 PRK12857
class II fructose-1,6-bisphosphate aldolase;
1-305 1.58e-136

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 237235  Cd Length: 284  Bit Score: 387.54  E-value: 1.58e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553   1 MLVTGNDILVPARAGKYAVGSFNTNNMEMTQAIIHTAERLRSPVMVQMSEGAIKYGGQD-LAHIVIDLAERASVPVALHL 79
Cdd:PRK12857   2 MLVTVAELLKKAEKGGYAVGAFNCNNMEIVQAIVAAAEAEKSPVIIQASQGAIKYAGIEyISAMVRTAAEKASVPVALHL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553  80 DHGSSYESVLRAIKMGFTSVMIDASHHPFEENVHETRRVVEAAHAMGISVESELGRLGGIEEHIVVDEKDAFLTDPEEAV 159
Cdd:PRK12857  82 DHGTDFEQVMKCIRNGFTSVMIDGSKLPLEENIALTKKVVEIAHAVGVSVEAELGKIGGTEDDITVDEREAAMTDPEEAR 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553 160 QFVEQTGTDYLAIAIGTSHGAYkgKGRPFIDQARIERISQLVSIPLVAHGSSGVPaeivqrfrdaggeigdaagiaDEDL 239
Cdd:PRK12857 162 RFVEETGVDALAIAIGTAHGPY--KGEPKLDFDRLAKIKELVNIPIVLHGSSGVP---------------------DEAI 218

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518418553 240 QQAAQHGIAKVNVDTDLRLALTVAVREVLQKTPKEFDPRKLFGPARDLMSQIIEHKMRVLGSVGQA 305
Cdd:PRK12857 219 RKAISLGVRKVNIDTNIREAFVARLREVLEKNPDEIDPRKILGPAREAAKEVIREKIRLFGSAGKA 284
TBP_aldolase_IIB cd00947
Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase ...
 5-303 2.86e-136

Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.


Pssm-ID: 238477  Cd Length: 276  Bit Score: 386.50  E-value: 2.86e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553   5 GNDILVPARAGKYAVGSFNTNNMEMTQAIIHTAERLRSPVMVQMSEGAIKYGGQD-LAHIVIDLAERASVPVALHLDHGS 83
Cdd:cd00947    1 TKELLKKAREGGYAVGAFNINNLETLKAILEAAEETRSPVILQISEGAIKYAGLElLVAMVKAAAERASVPVALHLDHGS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553  84 SYESVLRAIKMGFTSVMIDASHHPFEENVHETRRVVEAAHAMGISVESELGRLGGIEEHIVVDEkdAFLTDPEEAVQFVE 163
Cdd:cd00947   81 SFELIKRAIRAGFSSVMIDGSHLPFEENVAKTKEVVELAHAYGVSVEAELGRIGGEEDGVVGDE--GLLTDPEEAEEFVE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553 164 QTGTDYLAIAIGTSHGAYKGKGrPFIDQARIERISQLVSIPLVAHGSSGVPaeivqrfrdaggeigdaagiaDEDLQQAA 243
Cdd:cd00947  159 ETGVDALAVAIGTSHGAYKGGE-PKLDFDRLKEIAERVNVPLVLHGGSGIP---------------------DEQIRKAI 216

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553 244 QHGIAKVNVDTDLRLALTVAVREVLQKTPKEFDPRKLFGPARDLMSQIIEHKMRVLGSVG 303
Cdd:cd00947  217 KLGVCKININTDLRLAFTAALREYLAENPKEFDPRKYLAPAIEAVKEVVKHKMELFGSAG 276
 
Name Accession Description Interval E-value
Fba COG0191
Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose ...
 1-305 5.93e-150

Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose/tagatose bisphosphate aldolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439961  Cd Length: 283  Bit Score: 421.42  E-value: 5.93e-150
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553   1 MLVTGNDILVPARAGKYAVGSFNTNNMEMTQAIIHTAERLRSPVMVQMSEGAIKYGGQD-LAHIVIDLAERASVPVALHL 79
Cdd:COG0191    1 MLVSLKELLDKAKEGGYAVPAFNVNNLETLQAILEAAEELNSPVILQVSEGAAKYAGLEyLAAMVRAAAEEASVPVALHL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553  80 DHGSSYESVLRAIKMGFTSVMIDASHHPFEENVHETRRVVEAAHAMGISVESELGRLGGIEEHIVVDEKDAFLTDPEEAV 159
Cdd:COG0191   81 DHGASFELIKRAIDAGFTSVMIDGSHLPFEENIAITKEVVEYAHAAGVSVEAELGVVGGEEDGVDVDDAEALYTDPEEAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553 160 QFVEQTGTDYLAIAIGTSHGAYKGKgrPFIDQARIERISQLVSIPLVAHGSSGVPaeivqrfrdaggeigdaagiaDEDL 239
Cdd:COG0191  161 EFVEETGVDALAVAIGTVHGVYKGE--PKLDFDRLKEIREAVPVPLVLHGGSGVP---------------------DEEI 217

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518418553 240 QQAAQHGIAKVNVDTDLRLALTVAVREVLQKTPKEFDPRKLFGPARDLMSQIIEHKMRVLGSVGQA 305
Cdd:COG0191  218 REAIKLGVAKINIDTDLRLAFTAAVREYLAENPDKYDPRKYLKPAREAMKEVVKEKIRLFGSAGKA 283
fruc_bis_ald_ TIGR01859
fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; ...
 2-305 8.26e-149

fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; This model represents of one of several subtypes of the class II fructose-1,6-bisphosphate aldolase, an enzyme of glycolysis. The subtypes are split into several models to allow separation of a family of tagatose bisphosphate aldolases. This form is found in Gram-positive bacteria, a variety of Gram-negative, and in amitochondriate protists. The class II enzymes share homology with tagatose bisphosphate aldolase but not with class I aldolase. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 130918  Cd Length: 282  Bit Score: 418.69  E-value: 8.26e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553    2 LVTGNDILVPARAGKYAVGSFNTNNMEMTQAIIHTAERLRSPVMVQMSEGAIKYGG--QDLAHIVIDLAERAS-VPVALH 78
Cdd:TIGR01859   1 LVNGKEILQKAKKEGYAVGAFNFNNLEWTQAILEAAEEENSPVIIQVSEGAIKYMGgyKMAVAMVKTLIERMSiVPVALH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553   79 LDHGSSYESVLRAIKMGFTSVMIDASHHPFEENVHETRRVVEAAHAMGISVESELGRLGGIEEHivVDEKDAFLTDPEEA 158
Cdd:TIGR01859  81 LDHGSSYESCIKAIKAGFSSVMIDGSHLPFEENLALTKKVVEIAHAKGVSVEAELGTLGGIEDG--VDEKEAELADPDEA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553  159 VQFVEQTGTDYLAIAIGTSHGAYkgKGRPFIDQARIERISQLVSIPLVAHGSSGVPaeivqrfrdaggeigdaagiaDED 238
Cdd:TIGR01859 159 EQFVKETGVDYLAAAIGTSHGKY--KGEPGLDFERLKEIKELTNIPLVLHGASGIP---------------------EEQ 215

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518418553  239 LQQAAQHGIAKVNVDTDLRLALTVAVREVLQKTPKEFDPRKLFGPARDLMSQIIEHKMRVLGSVGQA 305
Cdd:TIGR01859 216 IKKAIKLGIAKINIDTDCRIAFTAAIRKVLTEKKDEYDPRKILGPAREAIKETVKEKMRLFGSAGKA 282
F_bP_aldolase pfam01116
Fructose-bisphosphate aldolase class-II;
3-304 2.26e-137

Fructose-bisphosphate aldolase class-II;


Pssm-ID: 460071  Cd Length: 276  Bit Score: 389.46  E-value: 2.26e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553    3 VTGNDILVPARAGKYAVGSFNTNNMEMTQAIIHTAERLRSPVMVQMSEGAIKY---GGQDLAHIVIDLAERASVPVALHL 79
Cdd:pfam01116   1 VNLKELLKKAKEGGYAVPAFNVNNLETVQAILEAAEEAKSPVILQVSPGAAAKyagGAEALAALVRAAAEAAGVPVALHL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553   80 DHGSSYESVLRAIKMGFTSVMIDASHHPFEENVHETRRVVEAAHAMGISVESELGRLGGIEEHIVVDEKdaFLTDPEEAV 159
Cdd:pfam01116  81 DHGASFELIKEAIEAGFTSVMIDGSHLPFEENIAITKEVVEYAHARGVSVEAELGRIGGEEDGVVVDEK--LYTDPEEAA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553  160 QFVEQTGTDYLAIAIGTSHGAYKGKGRpfIDQARIERISQLVSIPLVAHGSSGVPaeivqrfrdaggeigdaagiaDEDL 239
Cdd:pfam01116 159 EFVEATGVDALAVAIGNVHGVYKPGPK--LDFDRLKEIQEAVPVPLVLHGGSGVP---------------------DEDI 215

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 518418553  240 QQAAQHGIAKVNVDTDLRLALTVAVREVlqktPKEFDPRKLFGPARDLMSQIIEHKMRVLGSVGQ 304
Cdd:pfam01116 216 RKAIKLGVCKINIDTDLQLAFTAAVREY----PPNKDPRKYLRPAEEAMKEVVKEKIRLFGSAGK 276
PRK12857 PRK12857
class II fructose-1,6-bisphosphate aldolase;
1-305 1.58e-136

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 237235  Cd Length: 284  Bit Score: 387.54  E-value: 1.58e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553   1 MLVTGNDILVPARAGKYAVGSFNTNNMEMTQAIIHTAERLRSPVMVQMSEGAIKYGGQD-LAHIVIDLAERASVPVALHL 79
Cdd:PRK12857   2 MLVTVAELLKKAEKGGYAVGAFNCNNMEIVQAIVAAAEAEKSPVIIQASQGAIKYAGIEyISAMVRTAAEKASVPVALHL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553  80 DHGSSYESVLRAIKMGFTSVMIDASHHPFEENVHETRRVVEAAHAMGISVESELGRLGGIEEHIVVDEKDAFLTDPEEAV 159
Cdd:PRK12857  82 DHGTDFEQVMKCIRNGFTSVMIDGSKLPLEENIALTKKVVEIAHAVGVSVEAELGKIGGTEDDITVDEREAAMTDPEEAR 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553 160 QFVEQTGTDYLAIAIGTSHGAYkgKGRPFIDQARIERISQLVSIPLVAHGSSGVPaeivqrfrdaggeigdaagiaDEDL 239
Cdd:PRK12857 162 RFVEETGVDALAIAIGTAHGPY--KGEPKLDFDRLAKIKELVNIPIVLHGSSGVP---------------------DEAI 218

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518418553 240 QQAAQHGIAKVNVDTDLRLALTVAVREVLQKTPKEFDPRKLFGPARDLMSQIIEHKMRVLGSVGQA 305
Cdd:PRK12857 219 RKAISLGVRKVNIDTNIREAFVARLREVLEKNPDEIDPRKILGPAREAAKEVIREKIRLFGSAGKA 284
TBP_aldolase_IIB cd00947
Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase ...
 5-303 2.86e-136

Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.


Pssm-ID: 238477  Cd Length: 276  Bit Score: 386.50  E-value: 2.86e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553   5 GNDILVPARAGKYAVGSFNTNNMEMTQAIIHTAERLRSPVMVQMSEGAIKYGGQD-LAHIVIDLAERASVPVALHLDHGS 83
Cdd:cd00947    1 TKELLKKAREGGYAVGAFNINNLETLKAILEAAEETRSPVILQISEGAIKYAGLElLVAMVKAAAERASVPVALHLDHGS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553  84 SYESVLRAIKMGFTSVMIDASHHPFEENVHETRRVVEAAHAMGISVESELGRLGGIEEHIVVDEkdAFLTDPEEAVQFVE 163
Cdd:cd00947   81 SFELIKRAIRAGFSSVMIDGSHLPFEENVAKTKEVVELAHAYGVSVEAELGRIGGEEDGVVGDE--GLLTDPEEAEEFVE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553 164 QTGTDYLAIAIGTSHGAYKGKGrPFIDQARIERISQLVSIPLVAHGSSGVPaeivqrfrdaggeigdaagiaDEDLQQAA 243
Cdd:cd00947  159 ETGVDALAVAIGTSHGAYKGGE-PKLDFDRLKEIAERVNVPLVLHGGSGIP---------------------DEQIRKAI 216

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553 244 QHGIAKVNVDTDLRLALTVAVREVLQKTPKEFDPRKLFGPARDLMSQIIEHKMRVLGSVG 303
Cdd:cd00947  217 KLGVCKININTDLRLAFTAALREYLAENPKEFDPRKYLAPAIEAVKEVVKHKMELFGSAG 276
PRK05835 PRK05835
class II fructose-1,6-bisphosphate aldolase;
1-304 2.09e-121

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 180280 [Multi-domain]  Cd Length: 307  Bit Score: 350.43  E-value: 2.09e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553   1 MLVTGNDILVPARAGKYAVGSFNTNNMEMTQAIIHTAERLRSPVMVQMSEGAIKYGGQDLA-HIVIDLAER-ASVPVALH 78
Cdd:PRK05835   1 MLVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAvGMVKIMCERyPHIPVALH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553  79 LDHGSSYESVLRAIKMGFTSVMIDASHHPFEENVHETRRVVEAAHAMGISVESELGRLGGIEEHIVVDEKDAFLTDPEEA 158
Cdd:PRK05835  81 LDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNISVDEKDAVLVNPKEA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553 159 VQFVEQTGTDYLAIAIGTSHGAYKGKGRPFIDQARIERISQLVSIPLVAHGSSGVPAEIVQRFRDAGGEIGDAAGIADED 238
Cdd:PRK05835 161 EQFVKESQVDYLAPAIGTSHGAFKFKGEPKLDFERLQEVKRLTNIPLVLHGASAIPDDVRKSYLDAGGDLKGSKGVPFEF 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518418553 239 LQQAAQHGIAKVNVDTDLRLALTVAVREVLQKTPKEFDPRKLFGPARDLMSQIIEHKMRVLGSVGQ 304
Cdd:PRK05835 241 LQESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANK 306
cbbA TIGR00167
ketose-bisphosphate aldolase; This model is under revision. Proteins found by this model ...
 1-305 2.17e-111

ketose-bisphosphate aldolase; This model is under revision. Proteins found by this model include fructose-bisphosphate and tagatose-bisphosphate aldolase. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 272938  Cd Length: 288  Bit Score: 324.27  E-value: 2.17e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553    1 MLVTGNDILVPARAGKYAVGSFNTNNMEMTQAIIHTAERLRSPVMVQMSEGAIKY--GGQDLAHIVIDLAERAS--VPVA 76
Cdd:TIGR00167   2 MLVDVKELLQDAKEEGYAIPAFNINNLETINAVLEAAAEEKSPVIIQFSNGAAKYiaGLGAISAMVKAMSEAYPygVPVA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553   77 LHLDHGSSYESVLRAIKMGFTSVMIDASHHPFEENVHETRRVVEAAHAMGISVESELGRLGGIEEHIVVDEKDAFLTDPE 156
Cdd:TIGR00167  82 LHLDHGASEEDCAQAVKAGFSSVMIDGSHEPFEENIELTKKVVERAHKMGVSVEAELGTLGGEEDGVSVADESALYTDPE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553  157 EAVQFVEQTGTDYLAIAIGTSHGAYKGkGRPFIDQARIERISQLVSIPLVAHGSSGVPaeivqrfrdaggeigdaagiaD 236
Cdd:TIGR00167 162 EAKEFVKLTGVDSLAAAIGNVHGVYKG-EPKGLDFERLEEIQKYVNLPLVLHGGSGIP---------------------D 219

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 518418553  237 EDLQQAAQHGIAKVNVDTDLRLALTVAVREVLQKTPKEFDPRKLFGPARDLMSQIIEHKMRVLGSVGQA 305
Cdd:TIGR00167 220 EEIKKAISLGVVKVNIDTELQIAFAAAVRNYYAENKDYYDPRVWLRPGEKAMKEVVLEKIKLFGSANKA 288
gatY PRK12737
tagatose-bisphosphate aldolase subunit GatY;
1-305 2.74e-111

tagatose-bisphosphate aldolase subunit GatY;


Pssm-ID: 183710  Cd Length: 284  Bit Score: 323.57  E-value: 2.74e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553   1 MLVTGNDILVPARAGKYAVGSFNTNNMEMTQAIIHTAERLRSPVMVQMSEGAIKYGGQD-LAHIVIDLAERASVPVALHL 79
Cdd:PRK12737   2 YIISTKNMLKKAQAEGYAVPAFNIHNLETLQVVVETAAELRSPVILAGTPGTFSYAGTDyIVAIAEVAARKYNIPLALHL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553  80 DHGSSYESVLRAIKMGFTSVMIDASHHPFEENVHETRRVVEAAHAMGISVESELGRLGGIEEHIVVDEKDAFLTDPEEAV 159
Cdd:PRK12737  82 DHHEDLDDIKKKVRAGIRSVMIDGSHLSFEENIAIVKEVVEFCHRYDASVEAELGRLGGQEDDLVVDEKDAMYTNPDAAA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553 160 QFVEQTGTDYLAIAIGTSHGAYKGKgrPFIDQARIERISQLVSIPLVAHGSSGVPaeivqrfrdaggeigdaagiaDEDL 239
Cdd:PRK12737 162 EFVERTGIDSLAVAIGTAHGLYKGE--PKLDFERLAEIREKVSIPLVLHGASGVP---------------------DEDV 218

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518418553 240 QQAAQHGIAKVNVDTDLRLALTVAVREVLQKTPKEFDPRKLFGPARDLMSQIIEHKMRVLGSVGQA 305
Cdd:PRK12737 219 KKAISLGICKVNVATELKIAFSDAVKKYFYENPKANDPRKYMTPGKAAMKEVVREKIKVCGSEGKL 284
gatY PRK09195
tagatose-bisphosphate aldolase; Reviewed
 1-305 1.48e-105

tagatose-bisphosphate aldolase; Reviewed


Pssm-ID: 181690  Cd Length: 284  Bit Score: 308.98  E-value: 1.48e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553   1 MLVTGNDILVPARAGKYAVGSFNTNNMEMTQAIIHTAERLRSPVMVQMSEGAIKYGGQD-LAHIVIDLAERASVPVALHL 79
Cdd:PRK09195   2 YLVSTKQMLNNAQRGGYAVPAFNIHNLETMQVVVETAAELHSPVIIAGTPGTFSYAGTEyLLAIVSAAAKQYHHPLALHL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553  80 DHGSSYESVLRAIKMGFTSVMIDASHHPFEENVHETRRVVEAAHAMGISVESELGRLGGIEEHIVVDEKDAFLTDPEEAV 159
Cdd:PRK09195  82 DHHEKFDDIAQKVRSGVRSVMIDGSHLPFAQNISLVKEVVDFCHRFDVSVEAELGRLGGQEDDLQVDEADALYTDPAQAR 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553 160 QFVEQTGTDYLAIAIGTSHGAYKGKgrPFIDQARIERISQLVSIPLVAHGSSGVPaeivqrfrdaggeigdaagiaDEDL 239
Cdd:PRK09195 162 EFVEATGIDSLAVAIGTAHGMYKGE--PKLDFDRLENIRQWVNIPLVLHGASGLP---------------------TKDI 218

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518418553 240 QQAAQHGIAKVNVDTDLRLALTVAVREVLQKTPKEFDPRKLFGPARDLMSQIIEHKMRVLGSVGQA 305
Cdd:PRK09195 219 QQTIKLGICKVNVATELKIAFSQALKNYLTEHPEANDPRHYLQPAKSAMKDVVSKVIADCGCEGKA 284
PRK07084 PRK07084
class II fructose-1,6-bisphosphate aldolase;
2-305 6.52e-102

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 180829  Cd Length: 321  Bit Score: 301.26  E-value: 6.52e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553   2 LVTGNDILVPARAGKYAVGSFNTNNMEMTQAIIHTAERLRSPVMVQMSEGAIKYGGQDL----AHIVIDLAER--ASVPV 75
Cdd:PRK07084   9 LVNTREMFAKAVKGGYAIPAYNFNNMEQLQAIIQACVETKSPVILQVSKGARKYANATLlrymAQGAVEYAKElgCPIPI 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553  76 ALHLDHGSSYESVLRAIKMGFTSVMIDASHHPFEENVHETRRVVEAAHAMGISVESELGRLGGIEEHiVVDEKDAFlTDP 155
Cdd:PRK07084  89 VLHLDHGDSFELCKDCIDSGFSSVMIDGSHLPYEENVALTKKVVEYAHQFDVTVEGELGVLAGVEDE-VSAEHHTY-TQP 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553 156 EEAVQFVEQTGTDYLAIAIGTSHGAYK---GKGRPFIDQARIERISQ-LVSIPLVAHGSSGVPAEIVQRFRDAGGEIGDA 231
Cdd:PRK07084 167 EEVEDFVKKTGVDSLAISIGTSHGAYKfkpGQCPPPLRFDILEEIEKrIPGFPIVLHGSSSVPQEYVKTINEYGGKLKDA 246

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 518418553 232 AGIADEDLQQAAQHGIAKVNVDTDLRLALTVAVREVLQKTPKEFDPRKLFGPARDLMSQIIEHK-MRVLGSVGQA 305
Cdd:PRK07084 247 IGIPEEQLRKAAKSAVCKINIDSDGRLAMTAAIRKVFDEKPEEFDPRKYLGPARDELKKLYKHKiINVLGSNGKA 321
PRK09196 PRK09196
fructose-bisphosphate aldolase class II;
2-305 2.68e-100

fructose-bisphosphate aldolase class II;


Pssm-ID: 181691  Cd Length: 347  Bit Score: 298.02  E-value: 2.68e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553   2 LVTGNDILVPARAGKYAVGSFNTNNMEMTQAIIHTAERLRSPVMVQMSEGAIKYGGQD-LAHIVIDLAER-ASVPVALHL 79
Cdd:PRK09196   3 LISLRQLLDHAAEHGYGVPAFNVNNLEQVQAIMEAADETDSPVILQASAGARKYAGEPfLRHLILAAVEEyPHIPVVMHQ 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553  80 DHGSSYESVLRAIKMGFTSVMIDASHHP-------FEENVHETRRVVEAAHAMGISVESELGRLGGIEEHIVVDE----- 147
Cdd:PRK09196  83 DHGNSPATCQRAIQLGFTSVMMDGSLKAdgktpasYEYNVDVTRKVVEMAHACGVSVEGELGCLGSLETGMGGEEdghga 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553 148 -----KDAFLTDPEEAVQFVEQTGTDYLAIAIGTSHGAYKGKGRPFIDQARIERISQL-VSIP---LVAHGSSGVPAEIV 218
Cdd:PRK09196 163 egklsHDQLLTDPEEAADFVKKTQVDALAIAIGTSHGAYKFTRKPTGDVLAIDRIKEIhARLPnthLVMHGSSSVPQELL 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553 219 QRFRDAGGEIGDAAGIADEDLQQAAQHGIAKVNVDTDLRLALTVAVREVLQKTPKEFDPRKLFGPARDLMSQIIEHKMRV 298
Cdd:PRK09196 243 DIINEYGGDMPETYGVPVEEIQEGIKHGVRKVNIDTDLRLAMTGAIRRFLAENPSEFDPRKYLKPAMEAMKKICKARYEA 322


                 ....*..
gi 518418553 299 LGSVGQA 305
Cdd:PRK09196 323 FGTAGQA 329
PRK08185 PRK08185
hypothetical protein; Provisional
 7-305 6.66e-92

hypothetical protein; Provisional


Pssm-ID: 181275  Cd Length: 283  Bit Score: 274.30  E-value: 6.66e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553   7 DILVPARAGKYAVGSFNTNNMEMTQAIIHTAERLRSPVMVQMSEGAIKYGGQDLAHIVIDLAERASVPVALHLDHGSSYE 86
Cdd:PRK08185   3 ELLKVAKEHQFAVGAFNVADSCFLRAVVEEAEANNAPAIIAIHPNELDFLGDNFFAYVRERAKRSPVPFVIHLDHGATIE 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553  87 SVLRAIKMGFTSVMIDASHHPFEENVHETRRVVEAAHAMGISVESELGRLGGIEEHIVVDEKDAFLTDPEEAVQFVEQTG 166
Cdd:PRK08185  83 DVMRAIRCGFTSVMIDGSLLPYEENVALTKEVVELAHKVGVSVEGELGTIGNTGTSIEGGVSEIIYTDPEQAEDFVSRTG 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553 167 TDYLAIAIGTSHGAYKGKGRPFIDQARIERISQLVSIPLVAHGSSGVPaeivqrfrdaggeigdaagiaDEDLQQAAQHG 246
Cdd:PRK08185 163 VDTLAVAIGTAHGIYPKDKKPELQMDLLKEINERVDIPLVLHGGSANP---------------------DAEIAESVQLG 221

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 518418553 247 IAKVNVDTDLRLALTVAVREVLQKTPKEFDPRKLFGPARDLMSQIIEHKMRVLGSVGQA 305
Cdd:PRK08185 222 VGKINISSDMKYAFFKKVREILSDNPSLYEPNQIYPSAIEAAKEVVRHKMDLFNSTGKA 280
PRK08610 PRK08610
fructose-bisphosphate aldolase; Reviewed
 2-305 8.73e-89

fructose-bisphosphate aldolase; Reviewed


Pssm-ID: 181501  Cd Length: 286  Bit Score: 266.47  E-value: 8.73e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553   2 LVTGNDILVPARAGKYAVGSFNTNNMEMTQAIIHTAERLRSPVMVQMSEGAIKY--GGQDLAHIVIDLAE--RASVPVAL 77
Cdd:PRK08610   3 LVSMKEMLIDAKENGYAVGQYNLNNLEFTQAILEASQEENAPVILGVSEGAARYmsGFYTVVKMVEGLMHdlNITIPVAI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553  78 HLDHGSSYESVLRAIKMGFTSVMIDASHHPFEENVHETRRVVEAAHAMGISVESELGRLGGIEEHIVVDekDAFLTDPEE 157
Cdd:PRK08610  83 HLDHGSSFEKCKEAIDAGFTSVMIDASHSPFEENVATTKKVVEYAHEKGVSVEAELGTVGGQEDDVVAD--GIIYADPKE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553 158 AVQFVEQTGTDYLAIAIGTSHGAYKGKgrPFIDQARIERISQLVSIPLVAHGSSGVPAeivqrfrdaggeigdaagiadE 237
Cdd:PRK08610 161 CQELVEKTGIDALAPALGSVHGPYKGE--PKLGFKEMEEIGLSTGLPLVLHGGTGIPT---------------------K 217

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 518418553 238 DLQQAAQHGIAKVNVDTDLRLALTVAVREVLQKTPKEFDPRKLFGPARDLMSQIIEHKMRVLGSVGQA 305
Cdd:PRK08610 218 DIQKAIPFGTAKINVNTENQIASAKAVRDVLNNDKEVYDPRKYLGPAREAIKETVKGKIKEFGTSNRA 285
PRK07709 PRK07709
fructose-bisphosphate aldolase; Provisional
 2-305 1.81e-88

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 169068  Cd Length: 285  Bit Score: 265.76  E-value: 1.81e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553   2 LVTGNDILVPARAGKYAVGSFNTNNMEMTQAIIHTAERLRSPVMVQMSEGAIKY--GGQDLAHIVIDLAE--RASVPVAL 77
Cdd:PRK07709   3 LVSMKEMLNKALEGKYAVGQFNMNNLEWTQAILAAAEEEKSPVILGVSEGAARHmtGFKTVVAMVKALIEemNITVPVAI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553  78 HLDHGSSYESVLRAIKMGFTSVMIDASHHPFEENVHETRRVVEAAHAMGISVESELGRLGGIEEHIVVDekDAFLTDPEE 157
Cdd:PRK07709  83 HLDHGSSFEKCKEAIDAGFTSVMIDASHHPFEENVETTKKVVEYAHARNVSVEAELGTVGGQEDDVIAE--GVIYADPAE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553 158 AVQFVEQTGTDYLAIAIGTSHGAYKGKgrPFIDQARIERISQLVSIPLVAHGSSGVPAeivqrfrdaggeigdaagiadE 237
Cdd:PRK07709 161 CKHLVEATGIDCLAPALGSVHGPYKGE--PNLGFAEMEQVRDFTGVPLVLHGGTGIPT---------------------A 217

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 518418553 238 DLQQAAQHGIAKVNVDTDLRLALTVAVREVLQKTPKEFDPRKLFGPARDLMSQIIEHKMRVLGSVGQA 305
Cdd:PRK07709 218 DIEKAISLGTSKINVNTENQIEFTKAVREVLNKDQEVYDPRKFIGPGRDAIKATVIGKIREFGSNGKA 285
tag_bisphos_ald TIGR01858
class II aldolase, tagatose bisphosphate family; This model describes tagatose-1, ...
 2-305 2.16e-88

class II aldolase, tagatose bisphosphate family; This model describes tagatose-1,6-bisphosphate aldolases, and perhaps other closely related class II aldolases. This tetrameric, Zn2+-dependent enzyme is related to the class II fructose bisphosphate aldolase; fructose 1,6-bisphosphate and tagatose 1,6 bisphosphate differ only in chirality at C4.


Pssm-ID: 130917  Cd Length: 282  Bit Score: 265.57  E-value: 2.16e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553    2 LVTGNDILVPARAGKYAVGSFNTNNMEMTQAIIHTAERLRSPVMVQMSEGAIKYGGQD-LAHIVIDLAERASVPVALHLD 80
Cdd:TIGR01858   1 IVSTKYMLQDAQAGGYAVPAFNIHNLETIQAVVETAAEMRSPVILAGTPGTFKHAGTEyIVALCSAASTTYNMPLALHLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553   81 HGSSYESVLRAIKMGFTSVMIDASHHPFEENVHETRRVVEAAHAMGISVESELGRLGGIEEHIVVDEKDAFLTDPEEAVQ 160
Cdd:TIGR01858  81 HHESLDDIRQKVHAGVRSAMIDGSHFPFAQNVKLVKEVVDFCHRQDCSVEAELGRLGGVEDDLSVDEEDALYTDPQEAKE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553  161 FVEQTGTDYLAIAIGTSHGAYKGKgrPFIDQARIERISQLVSIPLVAHGSSGVPaeivqrfrdaggeigdaagiaDEDLQ 240
Cdd:TIGR01858 161 FVEATGVDSLAVAIGTAHGLYKKT--PKLDFDRLAEIREVVDVPLVLHGASDVP---------------------DEDVR 217

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 518418553  241 QAAQHGIAKVNVDTDLRLALTVAVREVLQKTPKEFDPRKLFGPARDLMSQIIEHKMRVLGSVGQA 305
Cdd:TIGR01858 218 RTIELGICKVNVATELKIAFSGAVKAYFAENPQANDPRYYMRPGKDAMKKVVRNKINVCGSAGRA 282
PRK13399 PRK13399
fructose-bisphosphate aldolase class II;
17-305 1.69e-86

fructose-bisphosphate aldolase class II;


Pssm-ID: 184029  Cd Length: 347  Bit Score: 262.79  E-value: 1.69e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553  17 YAVGSFNTNNMEMTQAIIHTAERLRSPVMVQMSEGAIKYGGQD-LAHIVIDLAE-RASVPVALHLDHGSSYESVLRAIKM 94
Cdd:PRK13399  18 YGVPAFNVNNMEQILAIMEAAEATDSPVILQASRGARKYAGDAmLRHMVLAAAEmYPDIPICLHQDHGNSPATCQSAIRS 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553  95 GFTSVMIDASHHP-------FEENVHETRRVVEAAHAMGISVESELGRLGGIEEHIVVDE----------KDAFLTDPEE 157
Cdd:PRK13399  98 GFTSVMMDGSLLAdgktpasYDYNVDVTRRVTEMAHAVGVSVEGELGCLGSLETGEAGEEdgvgaegklsHDQMLTDPDQ 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553 158 AVQFVEQTGTDYLAIAIGTSHGAYKGKGRPFIDQARIERISQL-VSIP---LVAHGSSGVPAEIVQRFRDAGGEIGDAAG 233
Cdd:PRK13399 178 AVDFVQRTGVDALAIAIGTSHGAYKFTRKPDGDILAIDRIEEIhARLPnthLVMHGSSSVPQELQEIINAYGGKMKETYG 257

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518418553 234 IADEDLQQAAQHGIAKVNVDTDLRLALTVAVREVLQKTPKEFDPRKLFGPARDLMSQIIEHKMRVLGSVGQA 305
Cdd:PRK13399 258 VPVEEIQRGIKHGVRKVNIDTDIRLAMTGAIRKVLAEHPSEFDPRKALKPAMKAMTALCKQRFEAFGTAGQA 329
kbaY PRK12738
tagatose-bisphosphate aldolase subunit KbaY;
8-301 3.73e-76

tagatose-bisphosphate aldolase subunit KbaY;


Pssm-ID: 183711  Cd Length: 286  Bit Score: 234.54  E-value: 3.73e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553   8 ILVPARAGKYAVGSFNTNNMEMTQAIIHTAERLRSPVMVQMSEGAIKY-GGQDLAHIVIDLAERASVPVALHLDHGSSYE 86
Cdd:PRK12738   9 LLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHiALEEIYALCSAYSTTYNMPLALHLDHHESLD 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553  87 SVLRAIKMGFTSVMIDASHHPFEENVHETRRVVEAAHAMGISVESELGRLGGIEEHIVVDEKDAFLTDPEEAVQFVEQTG 166
Cdd:PRK12738  89 DIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDMSVDAESAFLTDPQEAKRFVELTG 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553 167 TDYLAIAIGTSHGAYkgKGRPFIDQARIERISQLVSIPLVAHGSSGVPaeivqrfrdaggeigdaagiaDEDLQQAAQHG 246
Cdd:PRK12738 169 VDSLAVAIGTAHGLY--SKTPKIDFQRLAEIREVVDVPLVLHGASDVP---------------------DEFVRRTIELG 225

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 518418553 247 IAKVNVDTDLRLALTVAVREVLQKTPKEFDPRKLFGPARDLMSQIIEHKMRVLGS 301
Cdd:PRK12738 226 VTKVNVATELKIAFAGAVKAWFAENPQGNDPRYYMRVGMDAMKEVVRNKINVCGS 280
gatY PRK07998
class II aldolase;
2-301 1.92e-70

class II aldolase;


Pssm-ID: 181192  Cd Length: 283  Bit Score: 219.63  E-value: 1.92e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553   2 LVTGNDILVPARAGKYAVGSFNTNNMEMTQAIIHTAERLRSPVMVQMSEGAIKYGGQD-LAHIVIDLAERASVPVALHLD 80
Cdd:PRK07998   3 LVNGRILLDRIQEKHVLAGAFNTTNLETTISILNAIERSGLPNFIQIAPTNAQLSGYDyIYEIVKRHADKMDVPVSLHLD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553  81 HGSSYESVLRAIKMGFTSVMIDASHHPFEENVHETRRVVEAAHAMGISVESELGRLGGIE-EHivVDEKDAFlTDPEEAV 159
Cdd:PRK07998  83 HGKTFEDVKQAVRAGFTSVMIDGAALPFEENIAFTKEAVDFAKSYGVPVEAELGAILGKEdDH--VSEADCK-TEPEKVK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553 160 QFVEQTGTDYLAIAIGTSHGAYKgkgRPFIDQARIERISQLVSIPLVAHGSSGVPAEIVQRFRDaggeigdaagiadedl 239
Cdd:PRK07998 160 DFVERTGCDMLAVSIGNVHGLED---IPRIDIPLLKRIAEVSPVPLVIHGGSGIPPEILRSFVN---------------- 220

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518418553 240 qqaaqHGIAKVNVDTDLRLALTVAVREVLQKTPKEFDPRKLFGPARDLMSQIIEHKMRVLGS 301
Cdd:PRK07998 221 -----YKVAKVNIASDLRKAFITTVGKAYVNNHNEANLARVMAKAKQAVEEDVYSKIKMMNS 277
PRK06806 PRK06806
class II aldolase;
2-273 2.26e-69

class II aldolase;


Pssm-ID: 180705  Cd Length: 281  Bit Score: 216.93  E-value: 2.26e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553   2 LVTGNDILVPARAGKYAVGSFNTNNMEMTQAIIHTAERLRSPVMVQMSEGAIKYGGQDL-AHIVIDLAERASVPVALHLD 80
Cdd:PRK06806   3 LVQMKELLKKANQENYGVGAFSVANMEMVMGAIKAAEELNSPIILQIAEVRLNHSPLHLiGPLMVAAAKQAKVPVAVHFD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553  81 HGSSYESVLRAIKMGFTSVMIDASHHPFEENVHETRRVVEAAHAMGISVESELGRLGGIEEHivVDEKDAFLTDPEEAVQ 160
Cdd:PRK06806  83 HGMTFEKIKEALEIGFTSVMFDGSHLPLEENIQKTKEIVELAKQYGATVEAEIGRVGGSEDG--SEDIEMLLTSTTEAKR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553 161 FVEQTGTDYLAIAIGTSHGAYKGKgrPFIDQARIERISQLVSIPLVAHGSSgvpaeivqrfrdaggeigdaaGIADEDLQ 240
Cdd:PRK06806 161 FAEETDVDALAVAIGNAHGMYNGD--PNLRFDRLQEINDVVHIPLVLHGGS---------------------GISPEDFK 217

                        250       260       270
                 ....*....|....*....|....*....|...
gi 518418553 241 QAAQHGIAKVNVDTDLRLALTVAVREVLQKTPK 273
Cdd:PRK06806 218 KCIQHGIRKINVATATFNSVITAVNNLVLNTPY 250
PRK07315 PRK07315
fructose-bisphosphate aldolase; Provisional
 2-305 1.34e-65

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 180926  Cd Length: 293  Bit Score: 207.82  E-value: 1.34e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553   2 LVTGNDILVPARAGKYAVGSFNTNNMEMTQAIIHTAERLRSPVMVQMSEGAIKY-GGQDLAHIVID-LAERA--SVPVAL 77
Cdd:PRK07315   3 IVSAEKFVQAARDNGYAVGGFNTNNLEWTQAILRAAEAKKAPVLIQTSMGAAKYmGGYKVCKNLIEnLVESMgiTVPVAI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553  78 HLDHGSsYESVLRAIKMGFTSVMIDASHHPFEENVHETRRVVEAAHAMGISVESELGRLGGIEEHIVVDEKdafLTDPEE 157
Cdd:PRK07315  83 HLDHGH-YEDALECIEVGYTSIMFDGSHLPVEENLKLAKEVVEKAHAKGISVEAEVGTIGGEEDGIIGKGE---LAPIED 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553 158 AVQFVEqTGTDYLAIAIGTSHGAYKGKGRPfIDQARIERISQLVS-IPLVAHGSSGVPaeivqrfrdaggeigdaagiaD 236
Cdd:PRK07315 159 AKAMVE-TGIDFLAAGIGNIHGPYPENWEG-LDLDHLEKLTEAVPgFPIVLHGGSGIP---------------------D 215

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 518418553 237 EDLQQAAQHGIAKVNVDTDLRLALTVAVREVLQK---------TPKEFDPRKLFGPARDLMSQIIEHKMRVLGSVGQA 305
Cdd:PRK07315 216 DQIQEAIKLGVAKVNVNTECQIAFANATRKFARDyeaneaeydKKKLFDPRKFLAPGVKAIQASVEERIDVFGSANKA 293
PRK06801 PRK06801
ketose 1,6-bisphosphate aldolase;
2-305 1.98e-65

ketose 1,6-bisphosphate aldolase;


Pssm-ID: 180701  Cd Length: 286  Bit Score: 206.91  E-value: 1.98e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553   2 LVTGNDILVPARAGKYAVGSFNTNNMEMTQAIIHTAERLRSPVMVQMSEGAIKYGG-QDLAHIVIDLAERASVPVALHLD 80
Cdd:PRK06801   3 LISLANGLAHARKHGYALGAFNVLDSHFLRALFAAAKQERSPFIINIAEVHFKYISlESLVEAVKFEAARHDIPVVLNLD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553  81 HGSSYESVLRAIKMGFTSVMIDASHHPFEENVHETRRVVEAAHAMGISVESELGRLGGIEEHIVVDEKD-AFLTDPEEAV 159
Cdd:PRK06801  83 HGLHFEAVVRALRLGFSSVMFDGSTLEYEENVRQTREVVKMCHAVGVSVEAELGAVGGDEGGALYGEADsAKFTDPQLAR 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553 160 QFVEQTGTDYLAIAIGTSHGAYKGKgrPFIDQARIERISQLVSIPLVAHGSSgvpaeivqrfrdaggeigdaaGIADEDL 239
Cdd:PRK06801 163 DFVDRTGIDALAVAIGNAHGKYKGE--PKLDFARLAAIHQQTGLPLVLHGGS---------------------GISDADF 219

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518418553 240 QQAAQHGIAKVNVDTDLRLALTVAVREVLQKTPKEFDP-RKLFGPARDLMSQIIEHKMRVLGSVGQA 305
Cdd:PRK06801 220 RRAIELGIHKINFYTGMSQAALAAVEQRMTHRHAIYDEfAELLLGIEEAISDTVAQQMRIFGSAGQA 286
PLN02858 PLN02858
fructose-bisphosphate aldolase
 7-305 7.63e-60

fructose-bisphosphate aldolase


Pssm-ID: 215463 [Multi-domain]  Cd Length: 1378  Bit Score: 206.24  E-value: 7.63e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553    7 DILVPARAGKYAVGSFNTNNMEMTQAIIHTAERLRSPVMVQMSEGAIKYGGQDLAHIVIDLAERASVPVALHLDHGSSYE 86
Cdd:PLN02858 1104 ELLLNAEKGGYAVGAFNVYNLEGIEAVVAAAEAEKSPAILQVHPGALKQGGIPLVSCCIAAAEQASVPITVHFDHGTSKH 1183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553   87 SVLRAIKMGFTSVMIDASHHPFEENVHETRRVVEAAHAMGISVESELGRLGGIEEHIVVDEKDAFLTDPEEAVQFVEQTG 166
Cdd:PLN02858 1184 ELLEALELGFDSVMVDGSHLSFTENISYTKSISSLAHSKGLMVEAELGRLSGTEDGLTVEEYEAKLTDVDQAKEFIDETG 1263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553  167 TDYLAIAIGTSHGAYKGKGrPFIDQARIERISQLVS---IPLVAHGSSGVPAEIVqrfrdaggeigdaagiadedlQQAA 243
Cdd:PLN02858 1264 IDALAVCIGNVHGKYPASG-PNLRLDLLKELRALSSkkgVLLVLHGASGLPESLI---------------------KECI 1321

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518418553  244 QHGIAKVNVDTDLRLALTVAVRevlqkTPKEFDPRKLFGPARDLMSQIIEHKMRVLGSVGQA 305
Cdd:PLN02858 1322 ENGVRKFNVNTEVRTAYMEALS-----SPKKTDLIDVMSAAKEAMKAVVAEKLRLFGSAGKA 1378
FTBP_aldolase_II cd00453
Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1, ...
 8-302 1.93e-53

Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to yield fructose-1,6-bisphosphate. TBP-aldolase is tetrameric and produces tagarose-1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. Although structurally similar, the class I aldolases use a different mechanism and are believed to have an independent evolutionary origin.


Pssm-ID: 238255  Cd Length: 340  Bit Score: 177.69  E-value: 1.93e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553   8 ILVPARAGKYAVGSFNTNNMEMTQAIIHTAERLRSPVMVQMS-----------------EGAIKYGGQDLAHIVIDLAER 70
Cdd:cd00453    4 VFQVAKENNFALPAVNCVGTDSINAVLETAAKVKAPVIVQFSnggasfiagkgvksdvpQGAAILGAISGAHHVHQMAEH 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553  71 ASVPVALHLDH--GSSYESVLRAIKMG-----------FTSVMIDASHHPFEENVHETRRVVEAAHAMGISVESELGRLG 137
Cdd:cd00453   84 YGVPVILHTDHcaKKLLPWIDGLLDAGekhfaatgkplFSSHMIDLSEESLQENIEICSKYLERMSKIGMTLEIELGCTG 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553 138 GIEEHIVVDEKD--AFLTDPEEAVQFVEQTGT----DYLAIAIGTSHGAYKgKGRPFIDQARIERISQLVS--------- 202
Cdd:cd00453  164 GEEDGVDNSHMDasALYTQPEDVDYAYTELSKisprFTIAASFGNVHGVYK-KGNVVLTPTILRDSQEYVSkkhnlphns 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553 203 IPLVAHGSSGVPAEIVQRfrdaggeigdaagiadedlqqAAQHGIAKVNVDTDLRLALTVAVREVLQKTP---------- 272
Cdd:cd00453  243 LNFVFHGGSGSTAQEIKD---------------------SVSYGVVKMNIDTDTQWATWEGVLNYYKANEaylqgqlgnp 301

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 518418553 273 --------KEFDPRKLFGPARDLMSQIIEHKMRVLGSV 302
Cdd:cd00453  302 kgedqpnkKYYDPRVWLRAGQTSMIARLEKAFQELNAI 339
FBP_aldolase_IIA cd00946
Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the ...
 6-303 1.11e-24

Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is homodimeric and used in gluconeogenesis and glycolysis. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.


Pssm-ID: 238476  Cd Length: 345  Bit Score: 101.68  E-value: 1.11e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553   6 NDILVPARAGKYAVGSFNTNNMEMTQAIIHTAERLRSPVMVQMSEG--------AIKYGGQD--------LAHIVIDLAE 69
Cdd:cd00946    5 LKLFDYAKENGFAIPAVNCTSSSTINAVLEAARDAKSPIIIQFSNGgaafyagkGLKNEKQKasiagaiaAAHHVRSMAE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553  70 RASVPVALHLDHGSS-----YESVLRA----IKMG----FTSVMIDASHHPFEENVHETRRVVEAAHAMGISVESELGRL 136
Cdd:cd00946   85 HYGVPVVLHTDHCAKkllpwFDGLLEAdeeyFKQHgeplFSSHMLDLSEEPLEENIEICKKYLERMAKINMWLEMEIGIT 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553 137 GGIEEHivVDEKDA----FLTDPEEAVQFVEQ--TGTDYLAIA--IGTSHGAYKG---KGRPFI---DQARI-ERISQLV 201
Cdd:cd00946  165 GGEEDG--VDNSGVdnaeLYTQPEDVWYVYEAlsKISPNFSIAaaFGNVHGVYKPgnvKLQPEIlgeHQDYVrEKLGLAD 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553 202 SIPL--VAHGSSGVpaeivqrfrdaggeigdaagiADEDLQQAAQHGIAKVNVDTDLRLALTVAVREVLQK--------- 270
Cdd:cd00946  243 DKPLyfVFHGGSGS---------------------TKEEIREAISYGVVKMNIDTDTQWAYWEGVRNYYLKnedylqgqi 301

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 518418553 271 ---------TPKEFDPRKLFGPARDLMSQIIEHKMRVLGSVG 303
Cdd:cd00946  302 gnpegpdkpNKKYYDPRVWLREGEKSMVARVKKAFEDLNSVN 343
PRK09197 PRK09197
fructose-bisphosphate aldolase; Provisional
 3-303 1.54e-22

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 236406  Cd Length: 350  Bit Score: 95.63  E-value: 1.54e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553   3 VTGND---ILVPARAGKYAVGSFNTNNMEMTQAIIHTAERLRSPVMVQMSE-GAIKYGGQDL---------------AHI 63
Cdd:PRK09197   4 ATGEDyqeMFDRAKENGFALPAVNVVGTDSINAVLEGAAEAKSPVIIQFSNgGAAFIAGKGVkddgqgaavlgaiagAKH 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553  64 VIDLAERASVPVALHLDHGS-------------SYESVLRAIKMGFTSVMIDASHHPFEENVHETRRVVEAAHAMGISVE 130
Cdd:PRK09197  84 VHEVAEHYGVPVILHTDHCAkkllpwidglldaGEKHFAAGGKPLFSSHMIDLSEEPLEENIEICSKYLERMAKAGMTLE 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553 131 SELGRLGGiEEHIVVDE---KDAFLTDPEEAVQFVEQTGTD---YL-AIAIGTSHGAYK-G--KGRPFIDQARIERISQL 200
Cdd:PRK09197 164 IELGVTGG-EEDGVDNShedNSKLYTQPEDVLYAYEALGKIsgrFTiAASFGNVHGVYKpGnvKLRPEILKDSQEYVSKK 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518418553 201 V-----SIPLVAHGSSGVPAEivqrfrdaggEIGDAAGiadedlqqaaqHGIAKVNVDTDLRLALTVAVREVLQKTP--- 272
Cdd:PRK09197 243 FglpakPFDFVFHGGSGSTLE----------EIREAVS-----------YGVVKMNIDTDTQWAFWRGVLDYYFKNYdyl 301

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 518418553 273 ---------------KEFDPRKLFGPARDLMSQIIEHKMRVLGSVG 303
Cdd:PRK09197 302 qgqvgnpegedkpnkKYYDPRVWLRAAEASMAARLEEAFEDLNSIG 347
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH