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Conserved domains on  [gi|518412708|ref|WP_019582915|]
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MULTISPECIES: GntR family transcriptional regulator [Pseudomonas]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11448455)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain; controls the expression of genes with diverse biological functions

CATH:  1.10.10.10
Gene Ontology:  GO:0003700|GO:0003677
PubMed:  33509775
SCOP:  4000155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
16-229 3.06e-48

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 158.16  E-value: 3.06e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518412708  16 PIPAHLARSVIEETLRAAILDGRIPCGTALRQQDLADLFGVSRMPVREALRQLEAQALLNVIAHKGAVVAPLVQGDATET 95
Cdd:COG1802    6 PLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEIREL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518412708  96 YELRILLESEALRRSIPLLEDADFKQAARYIDELET---EHDYTEIGRLNRLFHMALYHKAPNQRLLKLVEDGLNEEERF 172
Cdd:COG1802   86 YEVRAALEGLAARLAAERATPADLARLRALLEELEAaaaAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRARLRRY 165

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 518412708 173 LRFNLEAMGLGKLSQEDHRALLRAAEDRDVEHSVMLLENHLNRGVEVITHYLASPEA 229
Cdd:COG1802  166 RRLSLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALAAAAA 222
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
16-229 3.06e-48

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 158.16  E-value: 3.06e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518412708  16 PIPAHLARSVIEETLRAAILDGRIPCGTALRQQDLADLFGVSRMPVREALRQLEAQALLNVIAHKGAVVAPLVQGDATET 95
Cdd:COG1802    6 PLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEIREL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518412708  96 YELRILLESEALRRSIPLLEDADFKQAARYIDELET---EHDYTEIGRLNRLFHMALYHKAPNQRLLKLVEDGLNEEERF 172
Cdd:COG1802   86 YEVRAALEGLAARLAAERATPADLARLRALLEELEAaaaAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRARLRRY 165

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 518412708 173 LRFNLEAMGLGKLSQEDHRALLRAAEDRDVEHSVMLLENHLNRGVEVITHYLASPEA 229
Cdd:COG1802  166 RRLSLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALAAAAA 222
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 94-211 1.75e-16

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 72.79  E-value: 1.75e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518412708   94 ETYELRILLESEALRRSIPLLEDADFKQAARYIDELET---EHDYTEIGRLNRLFHMALYHKAPNQRLLKLVEDGLNEEE 170
Cdd:pfam07729   1 ELYELRAALEPLAARLAAERATDEDLAELEALLEALEAaadAGDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 518412708  171 RFLRFNLEAMGLGKLSQEDHRALLRAAEDRDVEHSVMLLEN 211
Cdd:pfam07729  81 RLRRLLLSSPGRLRASLEEHRAILDAIRARDPEAARAAMRR 121
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 94-215 1.49e-14

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 67.77  E-value: 1.49e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518412708    94 ETYELRILLESEALRRSIPLLEDADFKQAARYIDELETEH----DYTEIGRLNRLFHMALYHKAPNQRLLKLVEDGLNEE 169
Cdd:smart00895   1 ELYEVRRALEPLAARLAAERATDEDLAALEALLDAMEAAAaagdDLEEFAELDREFHRALAEAAGNPVLLELLESLRARL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 518412708   170 ERFLRFNLEAMglgKLSQEDHRALLRAAEDRDVEHSVMLLENHLNR 215
Cdd:smart00895  81 RRLRRLSLEAA---RRALDEHRAILDAIRARDAEAARAAMREHLEA 123
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 26-85 8.03e-14

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 64.01  E-value: 8.03e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 518412708  26 IEETLRAAILDGRIPCGTALR-QQDLADLFGVSRMPVREALRQLEAQALLNVIAHKGAVVA 85
Cdd:cd07377    6 IADQLREAILSGELKPGDRLPsERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
PRK11534 PRK11534
DNA-binding transcriptional regulator CsiR; Provisional
 30-225 1.13e-08

DNA-binding transcriptional regulator CsiR; Provisional


Pssm-ID: 183181 [Multi-domain]  Cd Length: 224  Bit Score: 53.74  E-value: 1.13e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518412708  30 LRAAILDGRIPCGTALRQQDLADLFGVSRMPVREALRQLEAQALLNVIAHKGAVVAPLVQGDATETYELRILLESEALRR 109
Cdd:PRK11534  16 LKNDIIRGNFQPDEKLRMSLLTSRYALGVGPLREALSQLVAERLVTVVNQKGYRVASMSEQELLDIFDARANMEAMLVSL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518412708 110 SIPLLED---ADFKQAARYIDELE----TEHDYTEIGRLNRLFHMALYHKAPNQRLLKLVEDGLNEEERF----LRFNLE 178
Cdd:PRK11534  96 AIARGGDeweADVLAKAHLLSKLEacdaSEKMLDEWDLRHQAFHTAIVAGCGSHYLLQMRERLFDLAARYrfiwLRRTVL 175

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 518412708 179 AMGLGKLSQEDHRALLRAAEDRDVEHSVMLLENHLNRGVEVITHYLA 225
Cdd:PRK11534 176 SVEMLEDKHDQHQTLTAAILARDTARASELMRQHLLTPIPIIQQAMA 222
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
16-229 3.06e-48

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 158.16  E-value: 3.06e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518412708  16 PIPAHLARSVIEETLRAAILDGRIPCGTALRQQDLADLFGVSRMPVREALRQLEAQALLNVIAHKGAVVAPLVQGDATET 95
Cdd:COG1802    6 PLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEIREL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518412708  96 YELRILLESEALRRSIPLLEDADFKQAARYIDELET---EHDYTEIGRLNRLFHMALYHKAPNQRLLKLVEDGLNEEERF 172
Cdd:COG1802   86 YEVRAALEGLAARLAAERATPADLARLRALLEELEAaaaAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRARLRRY 165

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 518412708 173 LRFNLEAMGLGKLSQEDHRALLRAAEDRDVEHSVMLLENHLNRGVEVITHYLASPEA 229
Cdd:COG1802  166 RRLSLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALAAAAA 222
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
16-229 2.90e-22

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 91.15  E-value: 2.90e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518412708  16 PIPAHLARSVIEETLRAAILDGRIPCGTAL-RQQDLADLFGVSRMPVREALRQLEAQALLNVIAHKGAVVAPLVQGDATE 94
Cdd:COG2186    2 PIRRRSLAEQVAEQLRELILSGELKPGDRLpSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALLD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518412708  95 T---------------YELRILLESEALRRSIPLLEDADFKQAARYIDELETEH-DYTEIGRLNRLFHMALYHKAPNQRL 158
Cdd:COG2186   82 PlalllalddaslrdlLEARLALEPEAARLAAERATDEDLARLEAALAEMEAAAdDGEAFAEADLAFHRAIAEASGNPLL 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 518412708 159 LKLVEDGLNEEERFLRFNLEAMGLGKLSQEDHRALLRAAEDRDVEHSVMLLENHLNRGVEVITHYLASPEA 229
Cdd:COG2186  162 ALLLESLRELLRRSVRLTLRSPEARERSLAEHRAILDAIRAGDPEAARAAMRAHLEAVRERLREALAERAR 232
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 94-211 1.75e-16

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 72.79  E-value: 1.75e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518412708   94 ETYELRILLESEALRRSIPLLEDADFKQAARYIDELET---EHDYTEIGRLNRLFHMALYHKAPNQRLLKLVEDGLNEEE 170
Cdd:pfam07729   1 ELYELRAALEPLAARLAAERATDEDLAELEALLEALEAaadAGDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 518412708  171 RFLRFNLEAMGLGKLSQEDHRALLRAAEDRDVEHSVMLLEN 211
Cdd:pfam07729  81 RLRRLLLSSPGRLRASLEEHRAILDAIRARDPEAARAAMRR 121
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 94-215 1.49e-14

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 67.77  E-value: 1.49e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518412708    94 ETYELRILLESEALRRSIPLLEDADFKQAARYIDELETEH----DYTEIGRLNRLFHMALYHKAPNQRLLKLVEDGLNEE 169
Cdd:smart00895   1 ELYEVRRALEPLAARLAAERATDEDLAALEALLDAMEAAAaagdDLEEFAELDREFHRALAEAAGNPVLLELLESLRARL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 518412708   170 ERFLRFNLEAMglgKLSQEDHRALLRAAEDRDVEHSVMLLENHLNR 215
Cdd:smart00895  81 RRLRRLSLEAA---RRALDEHRAILDAIRARDAEAARAAMREHLEA 123
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 26-85 8.03e-14

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 64.01  E-value: 8.03e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 518412708  26 IEETLRAAILDGRIPCGTALR-QQDLADLFGVSRMPVREALRQLEAQALLNVIAHKGAVVA 85
Cdd:cd07377    6 IADQLREAILSGELKPGDRLPsERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 26-84 2.82e-12

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 59.94  E-value: 2.82e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 518412708   26 IEETLRAAILDGRIPCGTAL-RQQDLADLFGVSRMPVREALRQLEAQALLNVIAHKGAVV 84
Cdd:pfam00392   5 VYARLREDILSGRLRPGDKLpSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
26-84 4.62e-11

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 56.43  E-value: 4.62e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 518412708    26 IEETLRAAILDGRIPCGTALR-QQDLADLFGVSRMPVREALRQLEAQALLNVIAHKGAVV 84
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPsERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
PRK11534 PRK11534
DNA-binding transcriptional regulator CsiR; Provisional
 30-225 1.13e-08

DNA-binding transcriptional regulator CsiR; Provisional


Pssm-ID: 183181 [Multi-domain]  Cd Length: 224  Bit Score: 53.74  E-value: 1.13e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518412708  30 LRAAILDGRIPCGTALRQQDLADLFGVSRMPVREALRQLEAQALLNVIAHKGAVVAPLVQGDATETYELRILLESEALRR 109
Cdd:PRK11534  16 LKNDIIRGNFQPDEKLRMSLLTSRYALGVGPLREALSQLVAERLVTVVNQKGYRVASMSEQELLDIFDARANMEAMLVSL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518412708 110 SIPLLED---ADFKQAARYIDELE----TEHDYTEIGRLNRLFHMALYHKAPNQRLLKLVEDGLNEEERF----LRFNLE 178
Cdd:PRK11534  96 AIARGGDeweADVLAKAHLLSKLEacdaSEKMLDEWDLRHQAFHTAIVAGCGSHYLLQMRERLFDLAARYrfiwLRRTVL 175

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 518412708 179 AMGLGKLSQEDHRALLRAAEDRDVEHSVMLLENHLNRGVEVITHYLA 225
Cdd:PRK11534 176 SVEMLEDKHDQHQTLTAAILARDTARASELMRQHLLTPIPIIQQAMA 222
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
14-86 1.35e-08

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 53.71  E-value: 1.35e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 518412708  14 NGPIPAHLArsvIEETLRAAILDGRIPCGTAL-RQQDLADLFGVSRMPVREALRQLEAQALLNVIAHKGAVVAP 86
Cdd:COG2188    1 SSPVPLYLQ---IADALRERIESGELPPGDRLpSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAE 71
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 25-158 6.11e-08

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 51.69  E-value: 6.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518412708  25 VIEETLRAAILDGRIPCGTAL-RQQDLADLFGVSRMPVREALRQLEAQALLNVIAHKGAVVAPLV-QGDAT--------- 93
Cdd:PRK09990  11 VVAERIERLIVDGVLKVGQALpSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVARLNrVQDASplmhlfssq 90

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518412708  94 -----ETYELRILLESEALRRSIPLLEDADFKQAARYIDEL------ETEHDYTEIGRLNRLFHMALYHKAPNQRL 158
Cdd:PRK09990  91 prtlyDLLEVRALLEGESARLAALRGTQADFVLITRRYEEMlaahenNKEIDPIEHARLDHAFHLAICEASHNPVL 166
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 26-94 3.43e-07

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 50.21  E-value: 3.43e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518412708  26 IEETLRAAILDGRIPCGTAL---RQqdLADLFGVSRMPVREALRQLEAQALLNVIAHKGAVVAPLVQGDATE 94
Cdd:COG1167   17 LADALREAILSGRLPPGDRLpssRE--LAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAARLPAPAPA 86
PRK11414 PRK11414
GntR family transcriptional regulator;
26-220 2.13e-06

GntR family transcriptional regulator;


Pssm-ID: 183126 [Multi-domain]  Cd Length: 221  Bit Score: 47.17  E-value: 2.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518412708  26 IEETLRAAILDGRIPCGTALRQQDLADLFGVSRMPVREALRQLEAQALLNVIAHKGAVVAPLVQGDATETYELRILLESE 105
Cdd:PRK11414  16 VENDLKHQLSIGALKPGARLITKNLAEQLGMSITPVREALLRLVSVNALSVAPAQAFTVPEVSKRQLDEINRIRYELELM 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518412708 106 ALRRSIPLLEDADFKQAARYIDELETEH---DYTEIGRLNRLFHMALYHKAPNQRLLKLVEDGLNEEERFLRFNLEAMGL 182
Cdd:PRK11414  96 AVALAVENLTPQDLAELQELLEKLQQAQekgDMEQIINANRLFRLAIYHRSNMPILCEMIEQLWVRMGPSLHYLYEAINP 175

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 518412708 183 GKLSQ--EDHRALLRAAEDRDVEHSVMLLENHLNRGVEVI 220
Cdd:PRK11414 176 AELREhiENYRLLLAALKAKDKEGCRHCLAEIMQQNVAIL 215
PRK09764 PRK09764
GntR family transcriptional regulator;
26-84 7.11e-04

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 39.81  E-value: 7.11e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 518412708  26 IEETLRAAILDGRIPCGTAL-RQQDLADLFGVSRMPVREALRQLEAQALLNVIAHKGAVV 84
Cdd:PRK09764  10 IADRIREQIARGELKPGDALpTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYV 69
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
25-74 1.32e-03

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 38.85  E-value: 1.32e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 518412708  25 VIEETLRAAILDGRIPCGTAL-RQQDLADLFGVSRMPVREALRQLEAQALL 74
Cdd:PRK09464  14 VIEQQLEFLILEGTLRPGEKLpPERELAKQFDVSRPSLREAIQRLEAKGLL 64
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 26-215 1.44e-03

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 38.85  E-value: 1.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518412708  26 IEETLRAAILDGRIPCGTAL-RQQDLADLFGVSRMPVREALRQLEAQALLNvIAH--KGAVVAP-------LVQGDA--- 92
Cdd:PRK03837  18 VEERLEQMIRSGEFGPGDQLpSERELMAFFGVGRPAVREALQALKRKGLVQ-ISHgeRARVSRPsadtiigQLSGMAkdf 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518412708  93 --------TETYELRILLESEALRRsipLLEDADFKQAARYIDELETEH----DYTEIGRLNRLFHMALYHKAPNQRLLK 160
Cdd:PRK03837  97 lsqspdglAHLKQARLFFESSLARY---AAEHATDEQIALLRKALERNSqslgDNAAFIRSDMEFHRVIAEIPGNPIFMA 173

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 518412708 161 LVEDGLNEEERFLRFNLEAMGLGKLSQEDHRALLRAAEDRDVEHSVMLLENHLNR 215
Cdd:PRK03837 174 IHEALLDWLIEARPEVVILHGHENVTLQEHIAIVDAIRAHDPDEADRALQSHLNR 228
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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