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Conserved domains on  [gi|518377242|ref|WP_019547449|]
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putative quinol monooxygenase [Streptomyces sulphureus]

Protein Classification

putative quinol monooxygenase( domain architecture ID 10003583)

monooxygenase similar to Escherichia coli quinol monooxygenase YgiN that can oxidize menadiol to menadione, may be an antibiotic biosynthesis monooxygenase involved in the biosynthesis of antibiotics, such as Streptomyces tetracenomycin-F1 monooxygenase

CATH:  3.30.70.100
EC:  1.-.-.-
Gene Ontology:  GO:0004497|GO:0017000|GO:0016491
PubMed:  16496224
SCOP:  4000637

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YgiN COG1359
Quinol monooxygenase YgiN [Energy production and conversion];
2-88 6.89e-27

Quinol monooxygenase YgiN [Energy production and conversion];


:

Pssm-ID: 440970  Cd Length: 91  Bit Score: 94.63  E-value: 6.89e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518377242   2 IFITAKFEVRAEHAEEWPRIAAEFTEATRAEPGCLWFDWSRSLENPSEYVLLEAFRDDEAGGAHVNSAHFRAAQEKLPPY 81
Cdd:COG1359    1 ITVIAKLTVKPGKRDEFLAALRELVEATRAEPGCLSYELYRDPDDPNRFVLYERWEDEAALEAHLASPHFKAFLAALAPL 80


                 ....*..
gi 518377242  82 LVRTPKV 88
Cdd:COG1359   81 LAEPPEV 87
 
Name Accession Description Interval E-value
YgiN COG1359
Quinol monooxygenase YgiN [Energy production and conversion];
2-88 6.89e-27

Quinol monooxygenase YgiN [Energy production and conversion];


Pssm-ID: 440970  Cd Length: 91  Bit Score: 94.63  E-value: 6.89e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518377242   2 IFITAKFEVRAEHAEEWPRIAAEFTEATRAEPGCLWFDWSRSLENPSEYVLLEAFRDDEAGGAHVNSAHFRAAQEKLPPY 81
Cdd:COG1359    1 ITVIAKLTVKPGKRDEFLAALRELVEATRAEPGCLSYELYRDPDDPNRFVLYERWEDEAALEAHLASPHFKAFLAALAPL 80


                 ....*..
gi 518377242  82 LVRTPKV 88
Cdd:COG1359   81 LAEPPEV 87
ABM pfam03992
Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the ...
 2-75 4.51e-22

Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.


Pssm-ID: 427635  Cd Length: 74  Bit Score: 81.93  E-value: 4.51e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 518377242    2 IFITAKFEVRAEHAEEWPRIAAEFTEATRAEPGCLWFDWSRSLENPSEYVLLEAFRDDEAGGAHVNSAHFRAAQ 75
Cdd:pfam03992   1 IVVVAEIRVKPGKAEEFEEALAELVEATRNEPGCLSYELLRSLEDPDEYVVLEVWEDEAAFEAHLQSPHFKAAH 74
PRK10486 PRK10486
(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase;
27-80 3.03e-06

(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase;


Pssm-ID: 182494  Cd Length: 96  Bit Score: 42.02  E-value: 3.03e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 518377242  27 EATRAEPGCLWFDWSRSLENPSEYVLLEAFRDDEAGGAHVNSAHFRAAQEKLPP 80
Cdd:PRK10486  27 LGSIQEPGNLRFDVLQDPEVPTRFYIYEAYKDEAAVAFHKTTPHYKTCVEKLEP 80
 
Name Accession Description Interval E-value
YgiN COG1359
Quinol monooxygenase YgiN [Energy production and conversion];
2-88 6.89e-27

Quinol monooxygenase YgiN [Energy production and conversion];


Pssm-ID: 440970  Cd Length: 91  Bit Score: 94.63  E-value: 6.89e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518377242   2 IFITAKFEVRAEHAEEWPRIAAEFTEATRAEPGCLWFDWSRSLENPSEYVLLEAFRDDEAGGAHVNSAHFRAAQEKLPPY 81
Cdd:COG1359    1 ITVIAKLTVKPGKRDEFLAALRELVEATRAEPGCLSYELYRDPDDPNRFVLYERWEDEAALEAHLASPHFKAFLAALAPL 80


                 ....*..
gi 518377242  82 LVRTPKV 88
Cdd:COG1359   81 LAEPPEV 87
ABM pfam03992
Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the ...
 2-75 4.51e-22

Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.


Pssm-ID: 427635  Cd Length: 74  Bit Score: 81.93  E-value: 4.51e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 518377242    2 IFITAKFEVRAEHAEEWPRIAAEFTEATRAEPGCLWFDWSRSLENPSEYVLLEAFRDDEAGGAHVNSAHFRAAQ 75
Cdd:pfam03992   1 IVVVAEIRVKPGKAEEFEEALAELVEATRNEPGCLSYELLRSLEDPDEYVVLEVWEDEAAFEAHLQSPHFKAAH 74
HmoA COG2329
Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and ...
 1-89 2.57e-09

Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and metabolism];


Pssm-ID: 441901  Cd Length: 98  Bit Score: 49.99  E-value: 2.57e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518377242   1 MIFITAKFEVRAEHAEEWPRIAAEFTEATRAEPGCLWFDWSRSLENPSEYVLLEAFRDDEAGGAHVNSAHFRAAQEKLPP 80
Cdd:COG2329    1 MIVVINRFRVKPGQEEEFEEAFAERRELLAEQPGFLGFELLRSLEDPGEYLVVSYWESEEAFRAWFRSSEHRAAHAKGRE 80


                 ....*....
gi 518377242  81 YLVRTPKVV 89
Cdd:COG2329   81 ILAGPPRVE 89
PRK10486 PRK10486
(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase;
27-80 3.03e-06

(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase;


Pssm-ID: 182494  Cd Length: 96  Bit Score: 42.02  E-value: 3.03e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 518377242  27 EATRAEPGCLWFDWSRSLENPSEYVLLEAFRDDEAGGAHVNSAHFRAAQEKLPP 80
Cdd:PRK10486  27 LGSIQEPGNLRFDVLQDPEVPTRFYIYEAYKDEAAVAFHKTTPHYKTCVEKLEP 80
COG3224 COG3224
Antibiotic biosynthesis monooxygenase (ABM) superfamily enzyme [General function prediction ...
 10-107 4.37e-03

Antibiotic biosynthesis monooxygenase (ABM) superfamily enzyme [General function prediction only];


Pssm-ID: 442457  Cd Length: 183  Bit Score: 34.88  E-value: 4.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518377242  10 VRAEHAEEWPRIAAEFTEATRAEPGCLWFDWSRSLENPSEYVLLEAFRDDEAGGAHVNSAHFRAAQEKLPPYLVRTPKVV 89
Cdd:COG3224   15 VRPGREAEFEAWLREITALAARFPGFLGVGVIRPSGGSDEWVILLRFDSEENLDAWLESPERRAWLEEGEPLLEGEERVE 94

                         90
                 ....*....|....*...
gi 518377242  90 NVSlEQEGWSELGEMAVP 107
Cdd:COG3224   95 RRT-GLEGWFTPPGAPAA 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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