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Conserved domains on  [gi|518298013|ref|WP_019468221|]
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GTP cyclohydrolase FolE2 [Staphylococcus cohnii]

Protein Classification

GTP cyclohydrolase I FolE2( domain architecture ID 10014323)

GTP cyclohydrolase FolE2, a type Ib GTP cyclohydrolase, converts GTP to 7,8-dihydroneopterin triphosphate

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK13674 PRK13674
GTP cyclohydrolase I FolE2;
25-292 2.49e-127

GTP cyclohydrolase I FolE2;


:

Pssm-ID: 237466  Cd Length: 271  Bit Score: 363.35  E-value: 2.49e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518298013  25 TKPTVKEEMTDLQSTNKNYLFEIEEVGIKNLVYPVLVD-----RFQTAGNFSFSTSLNQDEKGINMSRILESVEKHYDNg 99
Cdd:PRK13674   1 TKPMMKATMPDVQSTPDTRLIPIDWVGIKNIRLPVRVDtrdggTQTTVARVDLTVSLPADFKGIHMSRLYELLEEHAEQ- 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518298013 100 iELDFDSLYRLLRSLQERMEQNAAGVDVSAKWFFDRHSPITNIKAVGHADVTYGMAIdKDSITRKEITLQAAVTTLCPCS 179
Cdd:PRK13674  80 -ELSPASLEQLLRDMLESLESRAARIEVSFPYFLRKPAPVSGLSGWKDYPVTLEAEL-RDGVFRLELKVEVPVSSLCPCS 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518298013 180 KEISEYSAHNQRGIITVKAILNNEAILtddYKEKILDAMEANASSILYPILKRPDEKSVTERAYENPRFVEDLIRLIAAD 259
Cdd:PRK13674 158 KAISRYTAHSQRSVATVKVRLAADAQL---WIEDLIDLAEAAASTPLQTLLKRPDEKAVTELAYENPMFVEDAARRVAAA 234
                        250       260       270
                 ....*....|....*....|....*....|...
gi 518298013 260 LVDFDWIEGFDIECRNEESIHQHDAFAKIKYRK 292
Cdd:PRK13674 235 LEADPRISAFRVEVEHFESIHNHDAVAVIEKDK 267
 
Name Accession Description Interval E-value
PRK13674 PRK13674
GTP cyclohydrolase I FolE2;
25-292 2.49e-127

GTP cyclohydrolase I FolE2;


Pssm-ID: 237466  Cd Length: 271  Bit Score: 363.35  E-value: 2.49e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518298013  25 TKPTVKEEMTDLQSTNKNYLFEIEEVGIKNLVYPVLVD-----RFQTAGNFSFSTSLNQDEKGINMSRILESVEKHYDNg 99
Cdd:PRK13674   1 TKPMMKATMPDVQSTPDTRLIPIDWVGIKNIRLPVRVDtrdggTQTTVARVDLTVSLPADFKGIHMSRLYELLEEHAEQ- 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518298013 100 iELDFDSLYRLLRSLQERMEQNAAGVDVSAKWFFDRHSPITNIKAVGHADVTYGMAIdKDSITRKEITLQAAVTTLCPCS 179
Cdd:PRK13674  80 -ELSPASLEQLLRDMLESLESRAARIEVSFPYFLRKPAPVSGLSGWKDYPVTLEAEL-RDGVFRLELKVEVPVSSLCPCS 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518298013 180 KEISEYSAHNQRGIITVKAILNNEAILtddYKEKILDAMEANASSILYPILKRPDEKSVTERAYENPRFVEDLIRLIAAD 259
Cdd:PRK13674 158 KAISRYTAHSQRSVATVKVRLAADAQL---WIEDLIDLAEAAASTPLQTLLKRPDEKAVTELAYENPMFVEDAARRVAAA 234
                        250       260       270
                 ....*....|....*....|....*....|...
gi 518298013 260 LVDFDWIEGFDIECRNEESIHQHDAFAKIKYRK 292
Cdd:PRK13674 235 LEADPRISAFRVEVEHFESIHNHDAVAVIEKDK 267
FolE2 COG1469
GTP cyclohydrolase FolE2 [Coenzyme transport and metabolism]; GTP cyclohydrolase FolE2 is part ...
32-292 2.27e-100

GTP cyclohydrolase FolE2 [Coenzyme transport and metabolism]; GTP cyclohydrolase FolE2 is part of the Pathway/BioSystem: Folate biosynthesis


Pssm-ID: 441078  Cd Length: 271  Bit Score: 294.75  E-value: 2.27e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518298013  32 EMTDLQSTNKNYLFEIEEVGIKNLVYPVLVDR-----FQTAGNFSFSTSLNQDEKGINMSRILESVEKHYDNgiELDFDS 106
Cdd:COG1469    1 TLPDVQSSPDDRNIPLDRVGIKGVRLPVRIADkdggpQHTVATFDMYVDLPADQKGTHMSRFVEVLDEHLEE--ALSVES 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518298013 107 LYRLLRSLQERMEQNAAGVDVSAKWFFDRHSPITNIKAVGHADVTYGMAIDKDSITRKEITLQAAVTTLCPCSKEISE-- 184
Cdd:COG1469   79 LEALLEEMAERLYAERAEVEMRFPYFIRKKAPVSGLSGLEDYDVTLEAELDRDGEFRKTLGVEVPVTSLCPCSKEISRql 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518298013 185 -------YSAHNQRGIITVKAILNNEAiltDDYKEKILDAMEANASSILYPILKRPDEKSVTERAYENPRFVEDLIRLIA 257
Cdd:COG1469  159 aqergipYGAHNQRSHATISVELDEDE---DVWIEDLIDLAESAASTPVYTLLKRPDEKAVTELAYENPKFVEDAVRDVA 235
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 518298013 258 ADLVDFDWIEGFDIECRNEESIHQHDAFAKIKYRK 292
Cdd:COG1469  236 AALVEDPRIADFRVEVENFESIHNHDAYAEIERDK 270
GCHY-1 pfam02649
Type I GTP cyclohydrolase folE2; This is a family of prokaryotic proteins with type I GTP ...
35-286 3.93e-94

Type I GTP cyclohydrolase folE2; This is a family of prokaryotic proteins with type I GTP cyclohydrolase activity. GTP cyclohydrolase I is the first enzyme of the de novo tetrahydrofolate biosynthetic pathway present in bacteria, fungi, and plants, and encoded in Escherichia coli by the folE gene; it is also the first enzyme of the biopterin (BH4) pathway in Homo sapiens. The invariate, highly conserved glutamate residue at position 216 in Swiss:Q5F9K6 is likely to be the substrate ligand and the metal ligand is likely to be the cysteine at position 147. The enzyme is Zinc 2+ dependent.


Pssm-ID: 460638  Cd Length: 262  Bit Score: 278.61  E-value: 3.93e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518298013   35 DLQSTNKNYLFEIEEVGIKNLVYPVLVDR-----FQTAGNFSFSTSLNQDEKGINMSRILESVEKHYDngiELDFDSLYR 109
Cdd:pfam02649   2 DVQSEPPDRNIPLDRVGVKGVRKPVRVKDkdgrpQHLVATFDLFVDLPADRKGIHMSRFVEALDEHEE---VLSEESLED 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518298013  110 LLRSLQERME-QNAAGVDVSAKWFFDRHSPITNIKAVGHADVTYGMAIDKDSITRKEITLQAAVTTLCPCSKEIS----- 183
Cdd:pfam02649  79 ILEELLERHEyAERAEVEMRFPYFIEKKAPVSGVKGLEDYDVTLEAELDRGGGVRKELGVEVPVTTLCPCSKEISrqliq 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518298013  184 ----EYSAHNQRGIITVKAILNNEAiltDDYKEKILDAMEANASSILYPILKRPDEKSVTERAYENPRFVEDLIRLIAAD 259
Cdd:pfam02649 159 ldgiPYGAHNQRSHATITVELKDGK---FVWIEDLIDIAESSASSPVYTLLKRPDEKAVTERAYENPKFVEDVVRDVAAR 235
                         250       260
                  ....*....|....*....|....*..
gi 518298013  260 LVDFDWIEGFDIECRNEESIHQHDAFA 286
Cdd:pfam02649 236 LNADPRVEAFRVEVENFESIHNHNAYA 262
TIGR00294 TIGR00294
GTP cyclohydrolase, MptA/FolE2 family; This family includes type I GTP cyclohydrolases ...
19-287 3.72e-45

GTP cyclohydrolase, MptA/FolE2 family; This family includes type I GTP cyclohydrolases involved in methanopterin in archaea (MptA) and de novo tetrahydrofolate biosynthesis in bacteria (FolE2). [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 129395  Cd Length: 308  Bit Score: 155.02  E-value: 3.72e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518298013   19 VDPIEGTKPTVKEEMTDLQS-TNKNYLFEI--EEVGIKNLVYPVLVDRF------QTAGNFSFSTSLNQDEkGINMSRIL 89
Cdd:TIGR00294  18 VTGIKKLVPVEREGKRPIILiSTFDVFVDLpsHQKGVHMSRNPEVITSVleeaeeTTAANFEMLCNEIVNQ-LLKKHRYA 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518298013   90 ESVEKHYDNGIELDFDS--LYRLLRSLQERMEQNAAGVDVSakWFFDRHSPITNIKAVGHADVTYGMAIDKDSITRKEIT 167
Cdd:TIGR00294  97 TLAEVYMNSDFILSKRSpkTGQFTQELAKIMGTASGTRDDD--FIFERKMVGAEVVGITACPCAQELVKEKSQPFLQEAG 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518298013  168 LQAAVttlCPCSKEISEYSAHNQRGIITvkaILNNEAILTDDYKEKILDAMEANASSILYPILKRPDEKSVTERAYENPR 247
Cdd:TIGR00294 175 FSDET---IPKILDIVEFATHNQRGRGR---IFTEVPSLPSIVIADLIDIAESSMSAELHEILKRPDEKAVVETAHENPR 248
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 518298013  248 FVEDLIRLIAADLVDFDWI--EGFDIECR--NEESIHQHDAFAK 287
Cdd:TIGR00294 249 FVEDCVRLMAARLVELFPHlpDDTEVECRqiNEESIHRHNAFAE 292
 
Name Accession Description Interval E-value
PRK13674 PRK13674
GTP cyclohydrolase I FolE2;
25-292 2.49e-127

GTP cyclohydrolase I FolE2;


Pssm-ID: 237466  Cd Length: 271  Bit Score: 363.35  E-value: 2.49e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518298013  25 TKPTVKEEMTDLQSTNKNYLFEIEEVGIKNLVYPVLVD-----RFQTAGNFSFSTSLNQDEKGINMSRILESVEKHYDNg 99
Cdd:PRK13674   1 TKPMMKATMPDVQSTPDTRLIPIDWVGIKNIRLPVRVDtrdggTQTTVARVDLTVSLPADFKGIHMSRLYELLEEHAEQ- 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518298013 100 iELDFDSLYRLLRSLQERMEQNAAGVDVSAKWFFDRHSPITNIKAVGHADVTYGMAIdKDSITRKEITLQAAVTTLCPCS 179
Cdd:PRK13674  80 -ELSPASLEQLLRDMLESLESRAARIEVSFPYFLRKPAPVSGLSGWKDYPVTLEAEL-RDGVFRLELKVEVPVSSLCPCS 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518298013 180 KEISEYSAHNQRGIITVKAILNNEAILtddYKEKILDAMEANASSILYPILKRPDEKSVTERAYENPRFVEDLIRLIAAD 259
Cdd:PRK13674 158 KAISRYTAHSQRSVATVKVRLAADAQL---WIEDLIDLAEAAASTPLQTLLKRPDEKAVTELAYENPMFVEDAARRVAAA 234
                        250       260       270
                 ....*....|....*....|....*....|...
gi 518298013 260 LVDFDWIEGFDIECRNEESIHQHDAFAKIKYRK 292
Cdd:PRK13674 235 LEADPRISAFRVEVEHFESIHNHDAVAVIEKDK 267
FolE2 COG1469
GTP cyclohydrolase FolE2 [Coenzyme transport and metabolism]; GTP cyclohydrolase FolE2 is part ...
32-292 2.27e-100

GTP cyclohydrolase FolE2 [Coenzyme transport and metabolism]; GTP cyclohydrolase FolE2 is part of the Pathway/BioSystem: Folate biosynthesis


Pssm-ID: 441078  Cd Length: 271  Bit Score: 294.75  E-value: 2.27e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518298013  32 EMTDLQSTNKNYLFEIEEVGIKNLVYPVLVDR-----FQTAGNFSFSTSLNQDEKGINMSRILESVEKHYDNgiELDFDS 106
Cdd:COG1469    1 TLPDVQSSPDDRNIPLDRVGIKGVRLPVRIADkdggpQHTVATFDMYVDLPADQKGTHMSRFVEVLDEHLEE--ALSVES 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518298013 107 LYRLLRSLQERMEQNAAGVDVSAKWFFDRHSPITNIKAVGHADVTYGMAIDKDSITRKEITLQAAVTTLCPCSKEISE-- 184
Cdd:COG1469   79 LEALLEEMAERLYAERAEVEMRFPYFIRKKAPVSGLSGLEDYDVTLEAELDRDGEFRKTLGVEVPVTSLCPCSKEISRql 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518298013 185 -------YSAHNQRGIITVKAILNNEAiltDDYKEKILDAMEANASSILYPILKRPDEKSVTERAYENPRFVEDLIRLIA 257
Cdd:COG1469  159 aqergipYGAHNQRSHATISVELDEDE---DVWIEDLIDLAESAASTPVYTLLKRPDEKAVTELAYENPKFVEDAVRDVA 235
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 518298013 258 ADLVDFDWIEGFDIECRNEESIHQHDAFAKIKYRK 292
Cdd:COG1469  236 AALVEDPRIADFRVEVENFESIHNHDAYAEIERDK 270
GCHY-1 pfam02649
Type I GTP cyclohydrolase folE2; This is a family of prokaryotic proteins with type I GTP ...
35-286 3.93e-94

Type I GTP cyclohydrolase folE2; This is a family of prokaryotic proteins with type I GTP cyclohydrolase activity. GTP cyclohydrolase I is the first enzyme of the de novo tetrahydrofolate biosynthetic pathway present in bacteria, fungi, and plants, and encoded in Escherichia coli by the folE gene; it is also the first enzyme of the biopterin (BH4) pathway in Homo sapiens. The invariate, highly conserved glutamate residue at position 216 in Swiss:Q5F9K6 is likely to be the substrate ligand and the metal ligand is likely to be the cysteine at position 147. The enzyme is Zinc 2+ dependent.


Pssm-ID: 460638  Cd Length: 262  Bit Score: 278.61  E-value: 3.93e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518298013   35 DLQSTNKNYLFEIEEVGIKNLVYPVLVDR-----FQTAGNFSFSTSLNQDEKGINMSRILESVEKHYDngiELDFDSLYR 109
Cdd:pfam02649   2 DVQSEPPDRNIPLDRVGVKGVRKPVRVKDkdgrpQHLVATFDLFVDLPADRKGIHMSRFVEALDEHEE---VLSEESLED 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518298013  110 LLRSLQERME-QNAAGVDVSAKWFFDRHSPITNIKAVGHADVTYGMAIDKDSITRKEITLQAAVTTLCPCSKEIS----- 183
Cdd:pfam02649  79 ILEELLERHEyAERAEVEMRFPYFIEKKAPVSGVKGLEDYDVTLEAELDRGGGVRKELGVEVPVTTLCPCSKEISrqliq 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518298013  184 ----EYSAHNQRGIITVKAILNNEAiltDDYKEKILDAMEANASSILYPILKRPDEKSVTERAYENPRFVEDLIRLIAAD 259
Cdd:pfam02649 159 ldgiPYGAHNQRSHATITVELKDGK---FVWIEDLIDIAESSASSPVYTLLKRPDEKAVTERAYENPKFVEDVVRDVAAR 235
                         250       260
                  ....*....|....*....|....*..
gi 518298013  260 LVDFDWIEGFDIECRNEESIHQHDAFA 286
Cdd:pfam02649 236 LNADPRVEAFRVEVENFESIHNHNAYA 262
TIGR00294 TIGR00294
GTP cyclohydrolase, MptA/FolE2 family; This family includes type I GTP cyclohydrolases ...
19-287 3.72e-45

GTP cyclohydrolase, MptA/FolE2 family; This family includes type I GTP cyclohydrolases involved in methanopterin in archaea (MptA) and de novo tetrahydrofolate biosynthesis in bacteria (FolE2). [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 129395  Cd Length: 308  Bit Score: 155.02  E-value: 3.72e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518298013   19 VDPIEGTKPTVKEEMTDLQS-TNKNYLFEI--EEVGIKNLVYPVLVDRF------QTAGNFSFSTSLNQDEkGINMSRIL 89
Cdd:TIGR00294  18 VTGIKKLVPVEREGKRPIILiSTFDVFVDLpsHQKGVHMSRNPEVITSVleeaeeTTAANFEMLCNEIVNQ-LLKKHRYA 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518298013   90 ESVEKHYDNGIELDFDS--LYRLLRSLQERMEQNAAGVDVSakWFFDRHSPITNIKAVGHADVTYGMAIDKDSITRKEIT 167
Cdd:TIGR00294  97 TLAEVYMNSDFILSKRSpkTGQFTQELAKIMGTASGTRDDD--FIFERKMVGAEVVGITACPCAQELVKEKSQPFLQEAG 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518298013  168 LQAAVttlCPCSKEISEYSAHNQRGIITvkaILNNEAILTDDYKEKILDAMEANASSILYPILKRPDEKSVTERAYENPR 247
Cdd:TIGR00294 175 FSDET---IPKILDIVEFATHNQRGRGR---IFTEVPSLPSIVIADLIDIAESSMSAELHEILKRPDEKAVVETAHENPR 248
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 518298013  248 FVEDLIRLIAADLVDFDWI--EGFDIECR--NEESIHQHDAFAK 287
Cdd:TIGR00294 249 FVEDCVRLMAARLVELFPHlpDDTEVECRqiNEESIHRHNAFAE 292
PRK13675 PRK13675
GTP cyclohydrolase; Provisional
31-289 8.65e-38

GTP cyclohydrolase; Provisional


Pssm-ID: 184232  Cd Length: 308  Bit Score: 135.44  E-value: 8.65e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518298013  31 EEMTDLQSTNKNYLFEIEEVGIKNLVYPVLVDRFQTAGNFSFST-----SLNQDEKGINMSRILESVEKHYDNGIELDFD 105
Cdd:PRK13675   2 MQLPDVQASEPDIKIGLTRVGVTNVKKLVKIKRKGKRPIVLIPTfevfvDLPSDRKGIHMSRNVEVIDEVLEEAVEEEVY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518298013 106 SL----YRLLRSLQERME-QNAAGVDVSAKWFFDRHSPITNIKAVGHADVTYGMAIDKDSITRKEITLQAAVTTLCPCSK 180
Cdd:PRK13675  82 EIedlcGDIAKRLLEKHEyATRAEVRMRSEYMMRRETPVSKKKSQEVVDIIAGAIATRDGNVRKEIGAEVVGMTACPCAQ 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518298013 181 EISEYSA-------------------------HNQRGI--ITVKAILNNEAILtddykEKILDAMEANASSILYPILKRP 233
Cdd:PRK13675 162 EMMKERArkklaelgvdeetiekfldnvpmatHNQRGRgtLTIEVPGDEDVSL-----EDIIDIIESSMSSPIYELLKRP 236
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 518298013 234 DEKSVTERAYENPRFVEDLIRLIAADLVD-FDWIEG---FDIECRNEESIHQHDAFAKIK 289
Cdd:PRK13675 237 DENAVVYEAHKNPKFVEDCVREMAKKVVEeFPHLPDdavVTVRQINEESIHRHNAFAERV 296
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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