|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05326 |
PRK05326 |
potassium/proton antiporter; |
3-570 |
0e+00 |
|
potassium/proton antiporter;
Pssm-ID: 235410 [Multi-domain] Cd Length: 562 Bit Score: 782.08 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 3 ASTINSLFVIGAVLVGASILLSSFSSRLGIPILVIFLAIGMLAGVDGPGGIVFSNYPVAYLVSNLALAVILLDGGMRTRV 82
Cdd:PRK05326 1 MDTINSLLLIGALLLLLSILASRLSSRLGIPSLLLFLAIGMLAGEDGLGGIQFDNYPLAYLVGNLALAVILFDGGLRTRW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 83 SSFRVALWPALSLATIGVVITAGLTGMAAAWLFNLDLLQGLLIGAIIGSTDAAAVFSLLGGKG--LNERVSATLEIESGS 160
Cdd:PRK05326 81 SSFRPALGPALSLATLGVLITAGLTGLFAHWLLGLDWLEGLLLGAIVGSTDAAAVFSLLRGKGlnLKERVASTLEIESGS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 161 NDPMAVFLTITLIAMIAAGETALSWTFPLHLMQQFGMGIVFGLGGGWLLLTLINHIKL-ADGLYPLLAVSGGILIFALTT 239
Cdd:PRK05326 161 NDPMAVFLTITLIELITGGETGLSWGFLLLFLQQFGLGALIGLLGGWLLVQLLNRIALpAEGLYPILVLAGALLIFALTA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 240 ALDGSGILAVYLCGLLLGNRPIRNRHGIVQTFDGLAWLSQIGMFLVLGLLLNPHELLPIAIPALLLSLWMILFARPLSVF 319
Cdd:PRK05326 241 ALGGSGFLAVYLAGLVLGNRPIRHRHSILRFFDGLAWLAQIGMFLVLGLLVTPSRLLDIALPALLLALFLILVARPLAVF 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 320 IGLLPFRsFTLRERGFISWVGLRGAVPVILAVFPMMAGLPNAQLFFNVAFFVVLVSLLLQGTTLSFAAKKAKVIVPPALT 399
Cdd:PRK05326 321 LSLLPFR-FNLREKLFISWVGLRGAVPIVLATFPMMAGLPNAQLIFNVVFFVVLVSLLLQGTTLPWAARKLGVVVPPEAR 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 400 PISRVGLDVHPENQWEQFVYQLSAENWCVGAALRELKMPPNTRIAALFRGKELLHPSGSTRLRENDILCVIGHEHDLPIL 479
Cdd:PRK05326 400 PVSRVELDPLEESDAELLEYRVPAGSWLVGKALRDLRLPRGALIALIIRDGKLLVPTGSTRLKAGDVLLVLGPERDLPAL 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 480 GKLFSQAPAVTLDERFFGDFILQSDARLSDISQVYGLNLqddvdEQQTLGQFVIQLIGGEPVIGDQVEWDGLTWTIAEme 559
Cdd:PRK05326 480 ERLFSQSPPGKLDQRFFGDFILEGDAKLADLALIYGLEL-----DQQTLGELIKQRLGGAPVVGDQVELGGIILTVAE-- 552
|
570
....*....|.
gi 518285667 560 gNQVSKIGVRI 570
Cdd:PRK05326 553 -GRVTKVGLRL 562
|
|
| NhaP2 |
COG3263 |
NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy ... |
5-498 |
0e+00 |
|
NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy production and conversion, Inorganic ion transport and metabolism];
Pssm-ID: 442494 [Multi-domain] Cd Length: 502 Bit Score: 668.35 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 5 TINSLFVIGAVLVGASILLSSFSSRLGIPILVIFLAIGMLAGVDGPGGIVFSNYPVAYLVSNLALAVILLDGGMRTRVSS 84
Cdd:COG3263 3 TLNLILLIGALLLLLSILASKLSSRLGVPLLLLFLGIGMLAGEDGLGGIQFDDAELAQLIGSLALAVILFDGGLRTRWSS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 85 FRVALWPALSLATIGVVITAGLTGMAAAWLFNLDLLQGLLIGAIIGSTDAAAVFSLLGGKG--LNERVSATLEIESGSND 162
Cdd:COG3263 83 FRPVLAPALSLATLGVLLTAGLTGVFAHWLLGLSWLEGLLLGAIVSSTDAAAVFSILRSKGlnLKERLASTLELESGSND 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 163 PMAVFLTITLIAMIAAGETALsWTFPLHLMQQFGMGIVFGLGGGWLLLTLINHIKL-ADGLYPLLAVSGGILIFALTTAL 241
Cdd:COG3263 163 PMAVFLTIALIELITGGGASG-WSLLLLFVLQMGLGALVGLAGGWLGVWLLNRIRLpAEGLYPVLVLALALLAFGATALL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 242 DGSGILAVYLCGLLLGNRPIRNRHGIVQTFDGLAWLSQIGMFLVLGLLLNPHELLPIAIPALLLSLWMILFARPLSVFIG 321
Cdd:COG3263 242 GGSGFLAVYLAGLVLGNRRLPHKKSILRFHDGLAWLAQIGMFLMLGLLVFPSRLLPVALPALLIALFLIFVARPLAVFLS 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 322 LLPFRsFTLRERGFISWVGLRGAVPVILAVFPMMAGLPNAQLFFNVAFFVVLVSLLLQGTTLSFAAKKAKVIVPPALTPI 401
Cdd:COG3263 322 LLPFR-FSWREKLFISWVGLRGAVPIVLATFPLLAGLPGAQLIFNVVFFVVLVSLLVQGTTLPPVARKLGLEVPPEPKPL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 402 SRVGLDVHPENQWEQFVYQLSAENWCVGAALRELKMPPNTRIAALFRGKELLHPSGSTRLRENDILCVIGHEHDLPILGK 481
Cdd:COG3263 401 TRVELELLEELDAELVEYRVPPGSPAVGKTLRELRLPEGALVVLIVRDGELLVPRGSTRLQAGDQLLVLAPPEDLEALER 480
|
490
....*....|....*..
gi 518285667 482 LFSQAPAVTLDERFFGD 498
Cdd:COG3263 481 LFAAVSRAGTLAEWFGD 497
|
|
| Na_H_Exchanger |
pfam00999 |
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ... |
15-389 |
2.14e-44 |
|
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.
Pssm-ID: 425982 [Multi-domain] Cd Length: 377 Bit Score: 161.65 E-value: 2.14e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 15 VLVGASILLSSFSSRLGIPILVIFLAIGMLAGVDGPGGIVfSNYPVAYLVSNLALAVILLDGGMRTRVSSFRVALWPALS 94
Cdd:pfam00999 3 LLILLALLAPLLARRLKLPPIVGLIIAGILLGPSGLGLIS-EVDEDLEVLSNLGLPPLLFLAGLELDLRELRKNGGSILL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 95 LATIGVVITAGLTGMAAAWL-FNLDLLQGLLIGAIIGSTDAAAVFSLLGGKG-LNERVSATLEIESGSNDPMAVFLTITL 172
Cdd:pfam00999 82 LALLGVLIPFVLIGLLLYLLgLGIPLLEALLFGAILSATSPVVVLAILKELGrVPERLGTLLLGESVLNDGVAVVLLAVL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 173 IAMI-AAGETALSWTFPLHLMQQFGMGIVFGLGGGWLLLTLINHIKLADGLYPLLAVSGGILIFALTTALDGSGILAVYL 251
Cdd:pfam00999 162 LALAqGVGGGSDLGWLLLIFLVVAVGGLLLGLLIGWLLRLITRFTDDDRELEVLLVLLLALLAALLAEALGVSGILGAFL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 252 CGLLLGNRPIRNRhgIVQTFDGLA-WLSQIGMFLVLGLLLNPHELLPIAIPALLLSLWMILFARPLSVFIGLLPFRsFTL 330
Cdd:pfam00999 242 AGLVLSEYPFANK--LSEKLEPFGyGLFNPLFFVLVGLSLDLSSLLLSVWILVLLALVAILLGRFLGVFLLLRLLG-LSL 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 331 RERGFISWVGL-RGAVPVILAVFPMMAGLPNAQLFFnVAFFVVLVSLLLQGTTLSFAAKK 389
Cdd:pfam00999 319 REALIIGFGGLqRGAVSLALAAIGPLLGIIARELYP-LLIVVVLFTVLVQGITLKPLLFK 377
|
|
| CorC_HlyC |
smart01091 |
Transporter associated domain; This small domain is found in a family of proteins with the ... |
492-571 |
1.38e-18 |
|
Transporter associated domain; This small domain is found in a family of proteins with the DUF21 domain and two CBS domains with this domain found at the C-terminus of the proteins, the domain is also found at the C terminus of some Na+/H+ antiporters. This domain is also found in CorC that is involved in Magnesium and cobalt efflux. The function of this domain is uncertain but might be involved in modulating transport of ion substrates.
Pssm-ID: 215020 [Multi-domain] Cd Length: 78 Bit Score: 80.18 E-value: 1.38e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 492 DERFFGDFILQSDARLSDISQVYGLNLQDDvdEQQTLGQFVIQLIGGEPVIGDQVEWDGLTWTIAEMEGNQVSKIGVRIV 571
Cdd:smart01091 1 VKLDDGSYLVDGRTPIDDLNELLGLDLPEE--EYDTLGGLVLEELGRIPEVGDSVEIGGLRFEVLEVDGRRIDKVRVTRP 78
|
|
| a_cpa1 |
TIGR00831 |
Na+/H+ antiporter, bacterial form; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC ... |
29-392 |
4.21e-16 |
|
Na+/H+ antiporter, bacterial form; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36) The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals. Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in (1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles. This model is specific for the bacterial members of this family. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 129911 [Multi-domain] Cd Length: 525 Bit Score: 81.08 E-value: 4.21e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 29 RLGIPILVIflAIGMLAGVDGPGGIVFSNYPVAYLvsnLALAVILLDGGMRTRVSSFRVALWPALSLATIGVVITAGLTG 108
Cdd:TIGR00831 21 RLPYPIALI--LAGLLLGLAGLLPEVPLDREIVLF---LFLPPLLFEAAMNTDLRELRENFRPIALIAFLLVVVTTVVVG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 109 MAAAWLFNLDLLQGLLIGAIIGSTDAAAVFSLLGGKGLNERVSATLEIESGSNDPMA-VFLTITLIAMIAAGETAlswtf 187
Cdd:TIGR00831 96 FSLNWILGIPLALALILGAVLSPTDAVAVLGTFKSIRAPKKLSILLEGESLLNDGAAlVVFAIAVAVALGKGVFD----- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 188 PLHLMQQFGMGIVFGLGGGWLLLTLINHIKLADGLYPLLAVSGGILI----FALTTALDGSGILAVYLCGLLLGNR---- 259
Cdd:TIGR00831 171 PLNAALDFAVVCVGGIAAGLAVGYLAYRLLRAKIDDPLVEIALTILApfagFLLAERFHFSGVIAVVAAGLILTNYgrdf 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 260 --PIRNRHGIVQTFDGLAWLSQIGMFLVLGL--------LLNPHELLPIAIPALLLSLWMILFAR-----------PLSV 318
Cdd:TIGR00831 251 smSPTTRLIALDFWSVIVFLVNGIIFILIGVqtpgtifsAWKEILVAPAAVILALFTNAFVIYPVmtyvrflwtmkPFSN 330
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 518285667 319 FIGLLPFRSFTLRERGFISWVGLRGAVPVILAV-FPMM----AGLPNAQLFFNVAFFVVLVSLLLQGTTLSFAAKKAKV 392
Cdd:TIGR00831 331 RFLKKKPMEFGTRWKHVVSWAGLRGAIPLALALsFPNQllsgMAFPARYELVFLAAGVILFSLLVQGISLPIFVKRKFV 409
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05326 |
PRK05326 |
potassium/proton antiporter; |
3-570 |
0e+00 |
|
potassium/proton antiporter;
Pssm-ID: 235410 [Multi-domain] Cd Length: 562 Bit Score: 782.08 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 3 ASTINSLFVIGAVLVGASILLSSFSSRLGIPILVIFLAIGMLAGVDGPGGIVFSNYPVAYLVSNLALAVILLDGGMRTRV 82
Cdd:PRK05326 1 MDTINSLLLIGALLLLLSILASRLSSRLGIPSLLLFLAIGMLAGEDGLGGIQFDNYPLAYLVGNLALAVILFDGGLRTRW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 83 SSFRVALWPALSLATIGVVITAGLTGMAAAWLFNLDLLQGLLIGAIIGSTDAAAVFSLLGGKG--LNERVSATLEIESGS 160
Cdd:PRK05326 81 SSFRPALGPALSLATLGVLITAGLTGLFAHWLLGLDWLEGLLLGAIVGSTDAAAVFSLLRGKGlnLKERVASTLEIESGS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 161 NDPMAVFLTITLIAMIAAGETALSWTFPLHLMQQFGMGIVFGLGGGWLLLTLINHIKL-ADGLYPLLAVSGGILIFALTT 239
Cdd:PRK05326 161 NDPMAVFLTITLIELITGGETGLSWGFLLLFLQQFGLGALIGLLGGWLLVQLLNRIALpAEGLYPILVLAGALLIFALTA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 240 ALDGSGILAVYLCGLLLGNRPIRNRHGIVQTFDGLAWLSQIGMFLVLGLLLNPHELLPIAIPALLLSLWMILFARPLSVF 319
Cdd:PRK05326 241 ALGGSGFLAVYLAGLVLGNRPIRHRHSILRFFDGLAWLAQIGMFLVLGLLVTPSRLLDIALPALLLALFLILVARPLAVF 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 320 IGLLPFRsFTLRERGFISWVGLRGAVPVILAVFPMMAGLPNAQLFFNVAFFVVLVSLLLQGTTLSFAAKKAKVIVPPALT 399
Cdd:PRK05326 321 LSLLPFR-FNLREKLFISWVGLRGAVPIVLATFPMMAGLPNAQLIFNVVFFVVLVSLLLQGTTLPWAARKLGVVVPPEAR 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 400 PISRVGLDVHPENQWEQFVYQLSAENWCVGAALRELKMPPNTRIAALFRGKELLHPSGSTRLRENDILCVIGHEHDLPIL 479
Cdd:PRK05326 400 PVSRVELDPLEESDAELLEYRVPAGSWLVGKALRDLRLPRGALIALIIRDGKLLVPTGSTRLKAGDVLLVLGPERDLPAL 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 480 GKLFSQAPAVTLDERFFGDFILQSDARLSDISQVYGLNLqddvdEQQTLGQFVIQLIGGEPVIGDQVEWDGLTWTIAEme 559
Cdd:PRK05326 480 ERLFSQSPPGKLDQRFFGDFILEGDAKLADLALIYGLEL-----DQQTLGELIKQRLGGAPVVGDQVELGGIILTVAE-- 552
|
570
....*....|.
gi 518285667 560 gNQVSKIGVRI 570
Cdd:PRK05326 553 -GRVTKVGLRL 562
|
|
| NhaP2 |
COG3263 |
NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy ... |
5-498 |
0e+00 |
|
NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy production and conversion, Inorganic ion transport and metabolism];
Pssm-ID: 442494 [Multi-domain] Cd Length: 502 Bit Score: 668.35 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 5 TINSLFVIGAVLVGASILLSSFSSRLGIPILVIFLAIGMLAGVDGPGGIVFSNYPVAYLVSNLALAVILLDGGMRTRVSS 84
Cdd:COG3263 3 TLNLILLIGALLLLLSILASKLSSRLGVPLLLLFLGIGMLAGEDGLGGIQFDDAELAQLIGSLALAVILFDGGLRTRWSS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 85 FRVALWPALSLATIGVVITAGLTGMAAAWLFNLDLLQGLLIGAIIGSTDAAAVFSLLGGKG--LNERVSATLEIESGSND 162
Cdd:COG3263 83 FRPVLAPALSLATLGVLLTAGLTGVFAHWLLGLSWLEGLLLGAIVSSTDAAAVFSILRSKGlnLKERLASTLELESGSND 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 163 PMAVFLTITLIAMIAAGETALsWTFPLHLMQQFGMGIVFGLGGGWLLLTLINHIKL-ADGLYPLLAVSGGILIFALTTAL 241
Cdd:COG3263 163 PMAVFLTIALIELITGGGASG-WSLLLLFVLQMGLGALVGLAGGWLGVWLLNRIRLpAEGLYPVLVLALALLAFGATALL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 242 DGSGILAVYLCGLLLGNRPIRNRHGIVQTFDGLAWLSQIGMFLVLGLLLNPHELLPIAIPALLLSLWMILFARPLSVFIG 321
Cdd:COG3263 242 GGSGFLAVYLAGLVLGNRRLPHKKSILRFHDGLAWLAQIGMFLMLGLLVFPSRLLPVALPALLIALFLIFVARPLAVFLS 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 322 LLPFRsFTLRERGFISWVGLRGAVPVILAVFPMMAGLPNAQLFFNVAFFVVLVSLLLQGTTLSFAAKKAKVIVPPALTPI 401
Cdd:COG3263 322 LLPFR-FSWREKLFISWVGLRGAVPIVLATFPLLAGLPGAQLIFNVVFFVVLVSLLVQGTTLPPVARKLGLEVPPEPKPL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 402 SRVGLDVHPENQWEQFVYQLSAENWCVGAALRELKMPPNTRIAALFRGKELLHPSGSTRLRENDILCVIGHEHDLPILGK 481
Cdd:COG3263 401 TRVELELLEELDAELVEYRVPPGSPAVGKTLRELRLPEGALVVLIVRDGELLVPRGSTRLQAGDQLLVLAPPEDLEALER 480
|
490
....*....|....*..
gi 518285667 482 LFSQAPAVTLDERFFGD 498
Cdd:COG3263 481 LFAAVSRAGTLAEWFGD 497
|
|
| NhaP |
COG0025 |
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism]; |
8-397 |
2.21e-59 |
|
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
Pssm-ID: 439796 [Multi-domain] Cd Length: 506 Bit Score: 205.58 E-value: 2.21e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 8 SLFVIGAVLVGASILLSSFSSRLGIPILVIFLAIGMLAGvDGPGGIVFSNYPVAYLVSNLALAVILLDGGMRTRVSSFRV 87
Cdd:COG0025 2 ELLLLILLLLLLGLLSQWLARRLKLPAPLLLLLAGILLG-PGLGLELDPELGDLEPLLELFLPPLLFEAALNLDLRELRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 88 ALWPALSLATIGVVITAGLTGMAAAWLFNLDLLQGLLIGAIIGSTDAAAVFSLLGGKGLNERVSATLEIESGSNDPMAVF 167
Cdd:COG0025 81 NGRPILRLAVVGVLLTTLAVALAAHWLLGLPLAAALLLGAILAPTDPVAVSPILRRLGVPKRLRTILEGESLLNDATALV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 168 LTITLIAMIAAGETALsWTFPLHLMQQFGMGIVFGLGGGWLLLTLINHIKlADGLYPLLAVSGGILIFALTTALDGSGIL 247
Cdd:COG0025 161 LFVLALAAALGGGFSL-GEALLDFLLAILGGILVGLLLGWLLGRLLRRLP-DPLLEILLTLALPFLAYLLAEALHGSGVL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 248 AVYLCGLLLGNR-----PIRNRHGIVQTFDGLAWLSQIGMFLVLGLLLNPHELLPIAIPALLLSLWMILFARPLSVFIGL 322
Cdd:COG0025 239 AVVVAGLVLGNAgrrslSPETRLQLLEFWETLEFLLNSLLFVLLGAQLPLILLGALGLGGILLVLLALLVVRPLWVFLSL 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 518285667 323 -LPFRSFTLRERGFISWVGLRGAVPVILAVFP---MMAGLPNAQLFFNVAFFVVLVSLLLQGTTLSFAAKKAKVIVPPA 397
Cdd:COG0025 319 aLRGSRLSWRERLFLSWGGPRGIVSLALALSLplhGGAGFPGRDLILALAFGVILLTLVLQGLTLPPLARRLGLREDEP 397
|
|
| Na_H_Exchanger |
pfam00999 |
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ... |
15-389 |
2.14e-44 |
|
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.
Pssm-ID: 425982 [Multi-domain] Cd Length: 377 Bit Score: 161.65 E-value: 2.14e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 15 VLVGASILLSSFSSRLGIPILVIFLAIGMLAGVDGPGGIVfSNYPVAYLVSNLALAVILLDGGMRTRVSSFRVALWPALS 94
Cdd:pfam00999 3 LLILLALLAPLLARRLKLPPIVGLIIAGILLGPSGLGLIS-EVDEDLEVLSNLGLPPLLFLAGLELDLRELRKNGGSILL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 95 LATIGVVITAGLTGMAAAWL-FNLDLLQGLLIGAIIGSTDAAAVFSLLGGKG-LNERVSATLEIESGSNDPMAVFLTITL 172
Cdd:pfam00999 82 LALLGVLIPFVLIGLLLYLLgLGIPLLEALLFGAILSATSPVVVLAILKELGrVPERLGTLLLGESVLNDGVAVVLLAVL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 173 IAMI-AAGETALSWTFPLHLMQQFGMGIVFGLGGGWLLLTLINHIKLADGLYPLLAVSGGILIFALTTALDGSGILAVYL 251
Cdd:pfam00999 162 LALAqGVGGGSDLGWLLLIFLVVAVGGLLLGLLIGWLLRLITRFTDDDRELEVLLVLLLALLAALLAEALGVSGILGAFL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 252 CGLLLGNRPIRNRhgIVQTFDGLA-WLSQIGMFLVLGLLLNPHELLPIAIPALLLSLWMILFARPLSVFIGLLPFRsFTL 330
Cdd:pfam00999 242 AGLVLSEYPFANK--LSEKLEPFGyGLFNPLFFVLVGLSLDLSSLLLSVWILVLLALVAILLGRFLGVFLLLRLLG-LSL 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 331 RERGFISWVGL-RGAVPVILAVFPMMAGLPNAQLFFnVAFFVVLVSLLLQGTTLSFAAKK 389
Cdd:pfam00999 319 REALIIGFGGLqRGAVSLALAAIGPLLGIIARELYP-LLIVVVLFTVLVQGITLKPLLFK 377
|
|
| CorC_HlyC |
smart01091 |
Transporter associated domain; This small domain is found in a family of proteins with the ... |
492-571 |
1.38e-18 |
|
Transporter associated domain; This small domain is found in a family of proteins with the DUF21 domain and two CBS domains with this domain found at the C-terminus of the proteins, the domain is also found at the C terminus of some Na+/H+ antiporters. This domain is also found in CorC that is involved in Magnesium and cobalt efflux. The function of this domain is uncertain but might be involved in modulating transport of ion substrates.
Pssm-ID: 215020 [Multi-domain] Cd Length: 78 Bit Score: 80.18 E-value: 1.38e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 492 DERFFGDFILQSDARLSDISQVYGLNLQDDvdEQQTLGQFVIQLIGGEPVIGDQVEWDGLTWTIAEMEGNQVSKIGVRIV 571
Cdd:smart01091 1 VKLDDGSYLVDGRTPIDDLNELLGLDLPEE--EYDTLGGLVLEELGRIPEVGDSVEIGGLRFEVLEVDGRRIDKVRVTRP 78
|
|
| KefB |
COG0475 |
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism]; ... |
8-391 |
3.23e-17 |
|
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism];
Pssm-ID: 440243 [Multi-domain] Cd Length: 384 Bit Score: 83.66 E-value: 3.23e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 8 SLFVIGAVLVGASILLSSFSSRLGIPILVIFLAIGMLAGVDGPGgiVFSNYPVAYLVSNLALAVILLDGGMRTRVSSFRV 87
Cdd:COG0475 4 SLLLQLGLLLLAAVLAGLLARRLGLPSVLGYILAGILLGPSGLG--LIEDSEALELLAELGVVLLLFLIGLELDLKRLRK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 88 ALWPALSLATIGVVITAGLtGMAAAWLFNLDLLQGLLIGAIIGSTDAAAVFSLLGGKGLNERVSATLEIESGSNDPMAVF 167
Cdd:COG0475 82 MGRRALGIGLLQVLLPFLL-GFLLALLLGLSLAAALFLGAALAATSTAIVLKVLKELGLLKTPLGQLILGVALFDDIAAI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 168 LTITLIAMIAAGETALswtfpLHLMQQFGMGIVFGLGGGWLLLTLINHI------KLADGLYPLLAVSGGILIFALTTAL 241
Cdd:COG0475 161 LLLALVPALAGGGSVA-----GSLLLALLKALLFLALLLLVGRYLLRRLfrlvarTRSRELFLLFALLLVLLAAALAELL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 242 DGSGILAVYLCGLLLGNRPirNRHGIVQTFDGLAWLSqIGMFLVL-GLLLNPHELLPIAIPALLLSLWMILfARPLSVFI 320
Cdd:COG0475 236 GLSAALGAFLAGLVLAESE--YRHELEEKIEPFGDLF-LPLFFVSvGLSLDLSALLSNPLLALLLVLAAIV-GKLLGAYL 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 518285667 321 GLLPFRsFTLRERgFISWVGL--RGAVPVILAVFPMMAGLPNAQLfFNVAFFVVLVSLLLQGTTLSFAAKKAK 391
Cdd:COG0475 312 AARLFG-LSRREA-LRIGLLLapRGEFALVLASLGLSAGLISPEL-FAALVLVVLLTTLLTPLLLRLALRLAE 381
|
|
| a_cpa1 |
TIGR00831 |
Na+/H+ antiporter, bacterial form; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC ... |
29-392 |
4.21e-16 |
|
Na+/H+ antiporter, bacterial form; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36) The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals. Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in (1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles. This model is specific for the bacterial members of this family. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 129911 [Multi-domain] Cd Length: 525 Bit Score: 81.08 E-value: 4.21e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 29 RLGIPILVIflAIGMLAGVDGPGGIVFSNYPVAYLvsnLALAVILLDGGMRTRVSSFRVALWPALSLATIGVVITAGLTG 108
Cdd:TIGR00831 21 RLPYPIALI--LAGLLLGLAGLLPEVPLDREIVLF---LFLPPLLFEAAMNTDLRELRENFRPIALIAFLLVVVTTVVVG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 109 MAAAWLFNLDLLQGLLIGAIIGSTDAAAVFSLLGGKGLNERVSATLEIESGSNDPMA-VFLTITLIAMIAAGETAlswtf 187
Cdd:TIGR00831 96 FSLNWILGIPLALALILGAVLSPTDAVAVLGTFKSIRAPKKLSILLEGESLLNDGAAlVVFAIAVAVALGKGVFD----- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 188 PLHLMQQFGMGIVFGLGGGWLLLTLINHIKLADGLYPLLAVSGGILI----FALTTALDGSGILAVYLCGLLLGNR---- 259
Cdd:TIGR00831 171 PLNAALDFAVVCVGGIAAGLAVGYLAYRLLRAKIDDPLVEIALTILApfagFLLAERFHFSGVIAVVAAGLILTNYgrdf 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 260 --PIRNRHGIVQTFDGLAWLSQIGMFLVLGL--------LLNPHELLPIAIPALLLSLWMILFAR-----------PLSV 318
Cdd:TIGR00831 251 smSPTTRLIALDFWSVIVFLVNGIIFILIGVqtpgtifsAWKEILVAPAAVILALFTNAFVIYPVmtyvrflwtmkPFSN 330
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 518285667 319 FIGLLPFRSFTLRERGFISWVGLRGAVPVILAV-FPMM----AGLPNAQLFFNVAFFVVLVSLLLQGTTLSFAAKKAKV 392
Cdd:TIGR00831 331 RFLKKKPMEFGTRWKHVVSWAGLRGAIPLALALsFPNQllsgMAFPARYELVFLAAGVILFSLLVQGISLPIFVKRKFV 409
|
|
| CorC_HlyC |
pfam03471 |
Transporter associated domain; This small domain is found in a family of proteins with the ... |
493-571 |
5.58e-14 |
|
Transporter associated domain; This small domain is found in a family of proteins with the pfam01595 domain and two CBS domains with this domain found at the C-terminus of the proteins, the domain is also found at the C terminus of some Na+/H+ antiporters. This domain is also found in CorC that is involved in Magnesium and cobalt efflux. The function of this domain is uncertain but might be involved in modulating transport of ion substrates.
Pssm-ID: 460935 [Multi-domain] Cd Length: 81 Bit Score: 67.19 E-value: 5.58e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 493 ERFFGDFILQSDARLSDISQVYGLNLQDDvdEQQTLGQFVIQLIGGEPVIGDQ--VEWDGLTWTIAEMEGNQVSKIGVRI 570
Cdd:pfam03471 2 KLDDGSYLVDGRAPLDDLNELLGLELPEE--DYDTLGGLVLERLGRIPKVGDKveVELGGLRFTVLEMDGRRIKKVRITK 79
|
.
gi 518285667 571 V 571
Cdd:pfam03471 80 L 80
|
|
| b_cpa1 |
TIGR00840 |
sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A. ... |
66-392 |
7.96e-13 |
|
sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36)The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals.Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in(1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles.This model is specific for the eukaryotic members members of this family. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273294 [Multi-domain] Cd Length: 559 Bit Score: 70.96 E-value: 7.96e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 66 NLALAVILLDGGMRTRVSSFRVALWPALSLATIGVVITAGLTG--MAAAWLF------NLDLLQGLLIGAIIGSTDAAAV 137
Cdd:TIGR00840 70 LYLLPPIVLDAGYFMPQRNFFENLGSILIFAVVGTLINAFVIGlsLYGICLIggfgsiDIGLLDNLLFGSLISAVDPVAV 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 138 FSLLGGKGLNERVSATLEIESGSNDPMAVFLTITLIAMIAAGETALSWT-----FPLHLMQQFGmGIVFGLGGGWLLLTL 212
Cdd:TIGR00840 150 LAVFEEYHVNEKLYIIIFGESLLNDAVTVVLYNTFIKFHKTADEPVTIVdvfegCASFFVVTCG-GLLVGVVFGFLVAFI 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 213 INHIKLADGLYPLLAVSGGILIFALTTALDGSGILAVYLCGLLL-----GNRPIRNRHGIVQTFDGLAWLSQIGMFLVLG 287
Cdd:TIGR00840 229 TRFTHHIRQIEPLFVFLISYLSYLFAETLHLSGILALIFCGITMkkyveANMSRRSQTTIKYFMKMLSSLSETLIFIFLG 308
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 288 L-LLNPHELLPIAIPALLLS---LWMILFARPLSVFIGLLPFRSFTLRERGFISWVGLRGAVPVILAVFPMMAGLPNAQL 363
Cdd:TIGR00840 309 VsLVTENHEWNWAFVVATLSfcvIYRVLGVRTLSWITNEFRPVEIPYKDQLVIFYAGLRGAVAFALALLLDEKIFPYKFL 388
|
330 340
....*....|....*....|....*....
gi 518285667 364 FFNVAFFVVLVSLLLQGTTLSFAAKKAKV 392
Cdd:TIGR00840 389 FVTTTLVVVFFTVIFQGGTIKPLVEVLKV 417
|
|
| TlyC |
COG1253 |
Hemolysin-related protein, contains CBS domains, UPF0053 family [General function prediction ... |
486-573 |
2.25e-09 |
|
Hemolysin-related protein, contains CBS domains, UPF0053 family [General function prediction only];
Pssm-ID: 440865 [Multi-domain] Cd Length: 435 Bit Score: 59.75 E-value: 2.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518285667 486 APAVTLDErffGDFILQSDARLSDISQVYGLNLqDDVDEQQTLGQFVIQLIGGEPVIGDQVEWDGLTWTIAEMEGNQVSK 565
Cdd:COG1253 347 PEIVKLDD---GSYLVDGRLPIDELNELLGLDL-PEEEDYETLGGLVLEQLGRIPEVGETVEVDGLRFEVLDMDGRRIDK 422
|
....*...
gi 518285667 566 IGVRIVTD 573
Cdd:COG1253 423 VLVTRLPE 430
|
|
| TrkA_C |
pfam02080 |
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ... |
421-483 |
2.16e-08 |
|
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.
Pssm-ID: 460440 [Multi-domain] Cd Length: 70 Bit Score: 51.07 E-value: 2.16e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 518285667 421 LSAENWCVGAALRELKMP--PNTRIAALFRGKELLHPSGSTRLRENDILCVIGHEHDLPILGKLF 483
Cdd:pfam02080 6 VPENSPLVGKTLKELNLPerFGVRIVAIRRGGRLIIPSGDTVLEAGDRLLVIGTPDDLAALRELL 70
|
|
| trkA |
PRK09496 |
Trk system potassium transporter TrkA; |
428-483 |
5.38e-06 |
|
Trk system potassium transporter TrkA;
Pssm-ID: 236541 [Multi-domain] Cd Length: 453 Bit Score: 48.97 E-value: 5.38e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 518285667 428 VGAALRELKM---PPNTRIAALFRGKELLHPSGSTRLRENDILCVIGHEHDLPILGKLF 483
Cdd:PRK09496 166 VGKPLSDLREhfpDIDVRVVAIFRGGRLIIPRGDTVIEAGDEVYFIGAREHIRAVMSEF 224
|
|
| trkA |
PRK09496 |
Trk system potassium transporter TrkA; |
427-483 |
1.90e-04 |
|
Trk system potassium transporter TrkA;
Pssm-ID: 236541 [Multi-domain] Cd Length: 453 Bit Score: 43.96 E-value: 1.90e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 518285667 427 CVGAALRELKMPPNTRIAALFRGKELLHPSGSTRLREND--ILCVIgHEHDLPILGKLF 483
Cdd:PRK09496 391 VVGKPLKDLKLPKGVLIGAIVRGGEVIIPTGDTVIEPGDhvIVFVL-DKKFVPDVEKLF 448
|
|
| TrkA |
COG0569 |
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ... |
419-467 |
3.19e-03 |
|
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];
Pssm-ID: 440335 [Multi-domain] Cd Length: 296 Bit Score: 39.66 E-value: 3.19e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 518285667 419 YQLSAENWCVGAALRELKMPPNT--RIAALFRGKELLHPSGSTRLRENDIL 467
Cdd:COG0569 245 VTVPEGSPLVGKTLKELDLRERYgvTVVAIKRGGEVIIPSGDTVLEAGDEL 295
|
|
| |
