|
Name |
Accession |
Description |
Interval |
E-value |
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
6-597 |
0e+00 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 1036.25 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 6 FFKSIHVKFVLVYILLIVIAMQIIGLYFARELEDTLKDSFIESIQQRVDLLEFSMrAEIIKKRGEEDPTIEQSLRTVLYS 85
Cdd:NF033092 1 FFRSIHFKIVLIYVLLILIAMQIIGVYFVRQLETQLLNNFKESINLRANLLSYNL-EQELSKEDEDDETLEEDIRTILND 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 86 VRSEDINEIRVVDTNFRILATSDTNKQSIVGQRSMDTNVRRSISSETPFNTIKVDLQKKDRIWVLASPIIY-QGEVLGAI 164
Cdd:NF033092 80 FNNNDISEIQVIDAKGTILGTSDPSNQSIVGQKTTDSDVKRALLGGKDNEKILIDPEDNNRVYVLATPIKSsNGEVVGAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 165 YLESNIETVFEQMSEINLILAGGTAMSLAITVILGILIAQTITRPISDMRRQAQAMAKGNFSRKVRVYGNDEIGQLAIAF 244
Cdd:NF033092 160 YIEASMESVYDQMNNINLIFATGTLIALVITAVLGILLARTITRPIKEMRKQALAMAKGDFSRKVKVYGNDEIGQLAEAF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 245 NHLTNRLQEAQSTTEGERRKLASVLSNMTDGVIATDRKGRIMLINETALRLLKVPRELVMHRPISVVLGIDSEYTFEDLI 324
Cdd:NF033092 240 NNLTKRLQEAQATTESERRKLDSVLSHMTDGVIATDRRGRVILINDPALEMLNVSRETVLGQSILDVLGLEEEYTLRDLL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 325 HMKDSINLDFSSPERNYILRVNFSVIQKETGFVNGIISVLHDNTEQEKIDMERREFVANVSHELRTPLTTMRSYLEALAD 404
Cdd:NF033092 320 EEQDSLLLDFSTEEEPLILRANFSVIQRESGFINGLIAVLHDVTEQEKIEQERREFVANVSHELRTPLTTMRSYLEALAD 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 405 GAWQDRELAPSFLNVTQTETERMIRLVNDLLQLSKMDSRSSDLNKELVEFNKFFNRIIDRFEM-SRSQDVHFLRLLPEAQ 483
Cdd:NF033092 400 GAWKDPELAPRFLGVTQNETERMIRLVNDLLQLSRMDSKDYKLNKEWVNFNEFFNYIIDRFEMiLKNKNITFKREFPKRD 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 484 YFVEIDTDKLTQVIDNIISNALKYSPDGGNIRFGCIVQGGLLKAMISDDGMGIPQENVERIFDRFYRVDRARARSMGGSG 563
Cdd:NF033092 480 LWVEIDTDKITQVLDNIISNAIKYSPEGGTITFRLLETHNRIIISISDQGLGIPKKDLDKIFDRFYRVDKARSRKMGGTG 559
|
570 580 590
....*....|....*....|....*....|....
gi 518245522 564 LGLAIAREMIEAHGGAIWAESEEGYGTTIFFTLP 597
Cdd:NF033092 560 LGLAIAKEVVEAHGGRIWAESEEGKGTTIYFTLP 593
|
|
| HK_VicK |
NF033093 |
cell wall metabolism sensor histidine kinase VicK; This model describes the protein VicK (or ... |
169-607 |
8.45e-129 |
|
cell wall metabolism sensor histidine kinase VicK; This model describes the protein VicK (or WalK) as found in Streptococcus pneumoniae, This protein is shorter than the WalK of Staphylococcus aureus, although apparently is functionally similar. Compare to model NF033092 (HK_WalK). VicK is a sensor histidine kinase involved in regulating cell wall metabolism. Its two component system partner is the response regulatory VicR.
Pssm-ID: 467965 [Multi-domain] Cd Length: 448 Bit Score: 385.61 E-value: 8.45e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 169 NIETVFEQMSEINLILaggtamsLAITVILGILIAQTITRPISDMRRQAQAMAK------GNFSRKVRVYGNDEIGQLAI 242
Cdd:NF033093 1 MIDNIKQNIFSFEFAF-------LLLLLGFILYFILLALRNRRDNKQLRQLNQKvkdliaGDYSEVLDMQGDPELTELTN 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 243 AFNHLTNRLQEAQSTTEGERRKLASVLSNMTDGVIATDRKGRIMLINETALRLLKVPRELVMHRPISVVLGIDSEYTFED 322
Cdd:NF033093 74 SLNDLSEVFRLTHENLEQEKNRLASILSYMTDGVLATNRRGQIIMINDTAQKQLNVKREEALNMNILDLLDIDDEYDLRD 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 323 LIHMKDSINLDFSSPERNYI-LRVNFSVIQKETGFVNGIISVLHDNTEQEKIDMERREFVANVSHELRTPLTTMRSYLEA 401
Cdd:NF033093 154 LITKTPELTLDSRDENGEFLsLRVRFALIRRESGFISGLVAVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 402 LADGAWqDRELAPSFLNVTQTETERMIRLVNDLLQLSKMDSRSSDLNKELVEFNKFFNRIIDRFEMSRSQD------VHF 475
Cdd:NF033093 234 LDEGAL-SEPVAPSFIKVSLDETNRMMRMISDLLSLSRIDNQTSHLDVELTNFTAFITFILNRFDQIKSQDtetgkkYEI 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 476 LRLLPEAQYFVEIDTDKLTQVIDNIISNALKYSPDGGNIRFGCIVQGGLLKAMISDDGMGIPQENVERIFDRFYRVDRAR 555
Cdd:NF033093 313 VRDYPITSIWVEIDTDKMTQVIDNILNNAIKYSPDGGKITVSMKTTDTQLIISISDEGLGIPKKDLPLIFDRFYRVDKAR 392
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 518245522 556 ARSMGGSGLGLAIAREMIEAHGGAIWAESEEGYGTTIFFTLPIELDEAG--EWD 607
Cdd:NF033093 393 SRAQGGTGLGLAIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDAVKddEWE 446
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
240-601 |
1.94e-96 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 300.32 E-value: 1.94e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 240 LAIAFNHLTNRLQEAQSTTEGERRKLASVLSNMTDGVIATDRKGRIMLINETALRLLKVPRELVMHRPISVVLGIDSEYT 319
Cdd:COG5002 28 LLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 320 FEDLIHMKDSINLDFSSPERNYILRVNFSVIQKETGFVNGIISVLHDNTEQEKIDMERREFVANVSHELRTPLTTMRSYL 399
Cdd:COG5002 108 LALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 400 EALADGAWQDRELAPSFLNVTQTETERMIRLVNDLLQLSKMDSRSSDLNKELVEFNKFFNRIIDRFE-MSRSQDVHFLRL 478
Cdd:COG5002 188 ELLLDGAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRpLAEEKGIELELD 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 479 LPEAQYFVEIDTDKLTQVIDNIISNALKYSPDGGNIRFGCIVQGGLLKAMISDDGMGIPQENVERIFDRFYRVDRARARS 558
Cdd:COG5002 268 LPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRE 347
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 518245522 559 MGGSGLGLAIAREMIEAHGGAIWAESEEGYGTTIFFTLPIELD 601
Cdd:COG5002 348 TGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLARE 390
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
180-603 |
1.12e-83 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 268.37 E-value: 1.12e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 180 INLILAGGTAMSLAITVILGILIAQTITRPISDMRRQAQAMAKGNFSRKVRVYGNDEIGQLAIAFNHLTNRLQEAQSTTE 259
Cdd:COG5000 7 FLLLLLLIALLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKEQREELE 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 260 GERRKLASVLSNMTDGVIATDRKGRIMLINETALRLLKVPRELVMHRPISVVLG-IDSEYTFEDLIHMKDSINLDFSSPE 338
Cdd:COG5000 87 ERRRYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGKPLEELLPeLDLAELLREALERGWQEEIELTRDG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 339 RNyILRVNFSVIQketgfVNGIISVLHDNTEQekIDMER----REFVANVSHELRTPLTTMRSYLE----ALADGAWQDR 410
Cdd:COG5000 167 RR-TLLVRASPLR-----DDGYVIVFDDITEL--LRAERlaawGELARRIAHEIKNPLTPIQLSAErlrrKLADKLEEDR 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 411 ELAPSFLNVTQTETERMIRLVNDLLQLSKMdsrsSDLNKELVEFNKFFNRIIDRFEMSRSQ-DVHFLRLLPEAQYFVEID 489
Cdd:COG5000 239 EDLERALDTIIRQVDRLKRIVDEFLDFARL----PEPQLEPVDLNELLREVLALYEPALKEkDIRLELDLDPDLPEVLAD 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 490 TDKLTQVIDNIISNALKYSPDGGNIRFGCIVQGGLLKAMISDDGMGIPQENVERIFDRFYrvdrararSM--GGSGLGLA 567
Cdd:COG5000 315 RDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFF--------TTkpKGTGLGLA 386
|
410 420 430
....*....|....*....|....*....|....*.
gi 518245522 568 IAREMIEAHGGAIWAESEEGYGTTIFFTLPIELDEA 603
Cdd:COG5000 387 IVKKIVEEHGGTIELESRPGGGTTFTIRLPLAEEAE 422
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
367-599 |
7.98e-74 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 236.34 E-value: 7.98e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 367 NTEQEKIDMERREFVANVSHELRTPLTTMRSYLEALADGAWQDRELAPSFLNVTQTETERMIRLVNDLLQLSKMDSRSSD 446
Cdd:COG2205 6 LEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLESGKLS 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 447 LNKELVEFNKFFNRIIDRFEMS-RSQDVHFLRLLPEAQYFVEIDTDKLTQVIDNIISNALKYSPDGGNIRFGCIVQGGLL 525
Cdd:COG2205 86 LELEPVDLAELLEEAVEELRPLaEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREGDGV 165
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 518245522 526 KAMISDDGMGIPQENVERIFDRFYRVDRARARsmGGSGLGLAIAREMIEAHGGAIWAESEEGYGTTIFFTLPIE 599
Cdd:COG2205 166 RISVSDNGPGIPEEELERIFERFYRGDNSRGE--GGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLA 237
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
371-599 |
1.10e-65 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 217.85 E-value: 1.10e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 371 EKIDMERREFVANVSHELRTPLTTMRSYLEALADGAWQDRElapSFLNVTQTETERMIRLVNDLLQLSKMDSRSSDLNKE 450
Cdd:COG0642 104 EEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQR---EYLETILRSADRLLRLINDLLDLSRLEAGKLELEPE 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 451 LVEFNKFFNRIIDRFE-MSRSQDVHFLRLLPEAQYFVEIDTDKLTQVIDNIISNALKYSPDGGNIRFGCIVQGGLLKAMI 529
Cdd:COG0642 181 PVDLAELLEEVVELFRpLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISV 260
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 530 SDDGMGIPQENVERIFDRFYRVDRARARsmGGSGLGLAIAREMIEAHGGAIWAESEEGYGTTIFFTLPIE 599
Cdd:COG0642 261 EDTGPGIPPEDLERIFEPFFRTDPSRRG--GGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPLA 328
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
263-596 |
1.14e-65 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 218.23 E-value: 1.14e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 263 RKLASVLSNMTDGVIATDRKGRIMLINETALRLLKVPRELVMHRPISVVLgidseyTFEDLIHM----KDSINLDFSSP- 337
Cdd:TIGR02966 6 SRFRAAAQALPDAVVVLDEEGQIEWCNPAAERLLGLRWPDDLGQRITNLI------RHPEFVEYlaagRFSEPLELPSPi 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 338 --ERNYILRVNFSviqketgFVNGIISVLHDNTEQEKIDMERREFVANVSHELRTPLTTMRSYLEALADGAWQDRELAPS 415
Cdd:TIGR02966 80 nsERVLEIRIAPY-------GEEQKLLVARDVTRLRRLEQMRRDFVANVSHELRTPLTVLRGYLETLADGPDEDPEEWNR 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 416 FLNVTQTETERMIRLVNDLLQLSKMDSRSSDLNKELVEFNKFFNRIIDRFEMSRSQDVHFLRLLPEAQYFVEIDTDKLTQ 495
Cdd:TIGR02966 153 ALEIMLEQSQRMQSLVEDLLTLSRLESAASPLEDEPVDMPALLDHLRDEAEALSQGKNHQITFEIDGGVDVLGDEDELRS 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 496 VIDNIISNALKYSPDGGNIRFGCIVQGGLLKAMISDDGMGIPQENVERIFDRFYRVDRARARSMGGSGLGLAIAREMIEA 575
Cdd:TIGR02966 233 AFSNLVSNAIKYTPEGGTITVRWRRDGGGAEFSVTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSR 312
|
330 340
....*....|....*....|.
gi 518245522 576 HGGAIWAESEEGYGTTIFFTL 596
Cdd:TIGR02966 313 HHARLEIESELGKGSTFSFIF 333
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
152-599 |
1.37e-59 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 209.44 E-value: 1.37e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 152 SPIIYQGEVLGAIYLESNIETVFEQMSEINL-ILAGgtamsLAITVILGILIAQTITRPISDMRRQaqaMAKGnfsrkVR 230
Cdd:PRK11360 160 IPIERNGEVIGYIWANELTEDIRRQAWKMDRrIYAV-----LAAGLVIGLLLIFLLSRRFSANVDI---IKDG-----LS 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 231 VYGND----------EIGQLAIAFNHLTNRLQEAQSTTEgerrklaSVLSNMTDGVIATDRKGRIMLINETALRLLKVPR 300
Cdd:PRK11360 227 TLENDlstrlpplpgELGEISQAINNLAQALRETRSLNE-------LILESIADGVIAIDRQGKITTMNPAAEVITGLQR 299
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 301 ELVMHRPISVVLGID---SEYTFEDLIHMKDSINLD--FSSPERNYILRVNFSVIQKETGFVNGIISVLHDNTEQEKidM 375
Cdd:PRK11360 300 HELVGKPYSELFPPNtpfASPLLDTLEHGTEHVDLEisFPGRDRTIELSVSTSLLHNTHGEMIGALVIFSDLTERKR--L 377
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 376 ERR-----------EFVANVSHELRTPLTTMRSYLEALADGAwqDRELAPSFLNVTQTETERMIRLVNDLLQLSkmdsRS 444
Cdd:PRK11360 378 QRRvarqerlaalgELVAGVAHEIRNPLTAIRGYVQIWRQQT--SDPPSQEYLSVVLREVDRLNKVIDQLLEFS----RP 451
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 445 SDLNKELVEFNKFFNRIIDRFEMSRSQD-VHFLRLLPEAQYFVEIDTDKLTQVIDNIISNALKYSPDGGNIRfgciVQGG 523
Cdd:PRK11360 452 RESQWQPVSLNALVEEVLQLFQTAGVQArVDFETELDNELPPIWADPELLKQVLLNILINAVQAISARGKIR----IRTW 527
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 524 LLKA-----MISDDGMGIPQENVERIFDRFYRVdraRARsmgGSGLGLAIAREMIEAHGGAIWAESEEGYGTTIFFTLPI 598
Cdd:PRK11360 528 QYSDgqvavSIEDNGCGIDPELLKKIFDPFFTT---KAK---GTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPI 601
|
.
gi 518245522 599 E 599
Cdd:PRK11360 602 N 602
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
261-603 |
1.95e-55 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 191.60 E-value: 1.95e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 261 ERRKLASVLSNMTDGVIATDRKGRIMLINETALRLLKVPRELVMHRPISVVLGIDSEYT--FEDLIHMKDSI---NLDFS 335
Cdd:COG3852 5 SEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFPEDSPLRelLERALAEGQPVterEVTLR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 336 SPE-RNYILRVNFSVIQKETGFVnGIISVLHDNTEQEKIDMERR---------EFVANVSHELRTPLTTMRSYLEALADG 405
Cdd:COG3852 85 RKDgEERPVDVSVSPLRDAEGEG-GVLLVLRDITERKRLERELRraeklaavgELAAGLAHEIRNPLTGIRGAAQLLERE 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 406 AwQDRELApSFLNVTQTETERMIRLVNDLLQLSkmdsRSSDLNKELVEFNKFFNRIIDRFEMSRSQDVHFLRLLPEAQYF 485
Cdd:COG3852 164 L-PDDELR-EYTQLIIEEADRLNNLVDRLLSFS----RPRPPEREPVNLHEVLERVLELLRAEAPKNIRIVRDYDPSLPE 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 486 VEIDTDKLTQVIDNIISNALKYSPDGGNIRF----------GCIVQGGLLKAMISDDGMGIPQENVERIFDRFYRvdrAR 555
Cdd:COG3852 238 VLGDPDQLIQVLLNLVRNAAEAMPEGGTITIrtrverqvtlGGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFFT---TK 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 518245522 556 ArsmGGSGLGLAIAREMIEAHGGAIWAESEEGYGTTIFFTLPIELDEA 603
Cdd:COG3852 315 E---KGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQAEE 359
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
363-600 |
3.68e-47 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 171.35 E-value: 3.68e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 363 VLHDNTEQEKIDMERREFVANVSHELRTPLTTMRSYLEALAD----GAWQDRELapsflNVTQTETERMIRLVNDLLQLS 438
Cdd:PRK11006 190 VARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQDqpleGALREKAL-----HTMREQTQRMEGLVKQLLTLS 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 439 KMD-SRSSDLNkELVEFNKFFnRIIDRFEMSRSQDVHFLRLLPEAQYFVEIDTDKLTQVIDNIISNALKYSPDGGNI--R 515
Cdd:PRK11006 265 KIEaAPTIDLN-EKVDVPMML-RVLEREAQTLSQGKHTITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHItvR 342
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 516 FGCIVQGGLLKamISDDGMGIPQENVERIFDRFYRVDRARARSMGGSGLGLAIAREMIEAHGGAIWAESEEGYGTTIFFT 595
Cdd:PRK11006 343 WQRVPQGAEFS--VEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFV 420
|
....*
gi 518245522 596 LPIEL 600
Cdd:PRK11006 421 LPERL 425
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
159-599 |
4.18e-44 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 164.57 E-value: 4.18e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 159 EVLGAIYLESNIETVFEQMSEINLILAGGTAMSLAITVILGILIAQTITRPISDMRRQAQAMAKGNFSRKVRVYGNDEIG 238
Cdd:COG4251 78 LALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLL 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 239 QLAIAFNHLTNRLQEAQSTTEGERRKLASVLSNMTDGVIATDRKGRIMLINETALRLLKVPRELVMHRPISVVLGIDSEY 318
Cdd:COG4251 158 LLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVL 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 319 TFEDLIHMKDSINLDFSSPERNYILRVNFSVIQKetgfvngiisvlhdNTEQEKIDMERREFVANVSHELRTPLTTMRSY 398
Cdd:COG4251 238 LLLLILLLLLLILVLELLELRLELEELEEELEER--------------TAELERSNEELEQFAYVASHDLREPLRKISGF 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 399 LEALA-DGAWQDRELAPSFLNVTQTETERMIRLVNDLLQLSKMDSRssDLNKELVEFNKFFNRIIDRFEMSRSQ-DVHF- 475
Cdd:COG4251 304 SQLLEeDYGDKLDEEGREYLERIRDAAERMQALIDDLLAYSRVGRQ--ELEFEPVDLNELLEEVLEDLEPRIEErGAEIe 381
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 476 LRLLPEaqyfVEIDTDKLTQVIDNIISNALKYSPDG--GNIRFGCIVQGGLLKAMISDDGMGIPQENVERIFDRFYRVDR 553
Cdd:COG4251 382 VGPLPT----VRGDPTLLRQVFQNLISNAIKYSRPGepPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHS 457
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 518245522 554 ARARSmgGSGLGLAIAREMIEAHGGAIWAESEEGYGTTIFFTLPIE 599
Cdd:COG4251 458 RDEYE--GTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPKA 501
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
262-602 |
5.64e-43 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 160.91 E-value: 5.64e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 262 RRKLASVLSNMTDGVIATDRKGRIMLINETALRLLKVPRELVMHRPISVVLGIDSEYTFEDLIHM----KDSINLDFSSP 337
Cdd:COG5809 140 EEKFRLIFNHSPDGIIVTDLDGRIIYANPAACKLLGISIEELIGKSILELIHSDDQENVAAFISQllkdGGIAQGEVRFW 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 338 ---ERNYILRVNFSVIqKETGFVNGIISVLHDNTEQEKIDMERR---------EFVANVSHELRTPLTTMRSYLEALADG 405
Cdd:COG5809 220 tkdGRWRLLEASGAPI-KKNGEVDGIVIIFRDITERKKLEELLRkseklsvvgELAAGIAHEIRNPLTSLKGFIQLLKDT 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 406 AWQDRElapSFLNVTQTETERMIRLVNDLLQLSKmdsrSSDLNKELVEFNKFFNRIIDRFE-MSRSQDVHFLRLLPEAQY 484
Cdd:COG5809 299 IDEEQK---TYLDIMLSELDRIESIISEFLVLAK----PQAIKYEPKDLNTLIEEVIPLLQpQALLKNVQIELELEDDIP 371
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 485 FVEIDTDKLTQVIDNIISNALKYSPDGGN--IRFGCIVQGGLLkAMISDDGMGIPQENVERIFDRFYrvdrarARSMGGS 562
Cdd:COG5809 372 DILGDENQLKQVFINLLKNAIEAMPEGGNitIETKAEDDDKVV-ISVTDEGCGIPEERLKKLGEPFY------TTKEKGT 444
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 518245522 563 GLGLAIAREMIEAHGGAIWAESEEGYGTTIFFTLPIELDE 602
Cdd:COG5809 445 GLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIKLSE 484
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
371-605 |
6.53e-42 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 157.49 E-value: 6.53e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 371 EKIDMERREFVANVSHELRTPLTTMRSYLEALADGAwqdRELAPSFLNVTQTETERMIRLVNDLLQLSKMDSRSSDLNKE 450
Cdd:PRK10549 234 EKNEQMRRDFMADISHELRTPLAVLRGELEAIQDGV---RKFTPESVASLQAEVGTLTKLVDDLHQLSLSDEGALAYRKT 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 451 LVEFNKFFNRII----DRFEmSRSQDVHfLRLLPEAQYFVeiDTDKLTQVIDNIISNALKYSPDGGNIRFGCIVQGGLLK 526
Cdd:PRK10549 311 PVDLVPLLEVAGgafrERFA-SRGLTLQ-LSLPDSATVFG--DPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLR 386
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 518245522 527 AMISDDGMGIPQENVERIFDRFYRVDRARARSMGGSGLGLAIAREMIEAHGGAIWAESEEGYGTTIFFTLPIELDEAGE 605
Cdd:PRK10549 387 LTFADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERDLQRE 465
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
380-597 |
1.11e-39 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 151.00 E-value: 1.11e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 380 FVANVSHELRTPLTTMRSYLE-ALAdgawQDRELAP--SFLNVTQTETERMIRLVNDLLQLSKMDSRSSDLNKELVEFNK 456
Cdd:TIGR01386 244 FSADLAHELRTPLTNLLGQTQvALS----QPRTGEEyrEVLESNLEELERLSRMVSDMLFLARADNGQLALERVRLDLAA 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 457 FFNRIIDRFE-MSRSQDVhflRLLPEAQYFVEIDTDKLTQVIDNIISNALKYSPDGGNIRFGCIVQGGLLKAMISDDGMG 535
Cdd:TIGR01386 320 ELAKVAEYFEpLAEERGV---RIRVEGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGPG 396
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518245522 536 IPQENVERIFDRFYRVDRARARSMGGSGLGLAIAREMIEAHGGAIWAESEEGYgTTIFFTLP 597
Cdd:TIGR01386 397 IPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDGK-TRFILRFP 457
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
358-597 |
1.33e-38 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 148.05 E-value: 1.33e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 358 NGIISVLHDNTEQekidmeRREFVANVSHELRTPLTTMRSYLEALADGAwqdRELAPSFLNVTQTETERMIRLVNDLLQL 437
Cdd:NF012163 227 NQLASTLEKNEQM------RRDFMADISHELRTPLAVLRAELEAIQDGI---RKFTPESLDSLQAEVGTLTKLVDDLHDL 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 438 SKMDS-----RSSDLNKE---LVEFNKFFnriiDRFEmSRSQDVHFlrLLPEAQYFVEiDTDKLTQVIDNIISNALKYSP 509
Cdd:NF012163 298 SMSDEgalayQKASVDLVpllEVEGGAFR----ERFA-SAGLELEV--SLPDSSLVFG-DRDRLMQLFNNLLENSLRYTD 369
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 510 DGGNIRFGCIVQGGLLKAMISDDGMGIPQENVERIFDRFYRVDRARARSMGGSGLGLAIAREMIEAHGGAIWAESEEGYG 589
Cdd:NF012163 370 SGGSLHISASQRPKEVTLTVADSAPGVSDEQLARLFERFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTLHAAHSPLGG 449
|
....*...
gi 518245522 590 TTIFFTLP 597
Cdd:NF012163 450 LRIVVTLP 457
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
379-598 |
6.22e-36 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 138.39 E-value: 6.22e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 379 EFVANVSHELRTPLTTMRSYLEALAD--GAWQDRELAPSFLNVTQTETERMIRLVNDLLQLSkmdsRSSDLNKELVEFNK 456
Cdd:COG4191 144 ELAAGIAHEINNPLAAILGNAELLRRrlEDEPDPEELREALERILEGAERAAEIVRSLRAFS----RRDEEEREPVDLNE 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 457 FFNRIIDRFEMS-RSQDVHFLRLLPEAQYFVEIDTDKLTQVIDNIISNALKYSPDG--GNIRFGCIVQGGLLKAMISDDG 533
Cdd:COG4191 220 LIDEALELLRPRlKARGIEVELDLPPDLPPVLGDPGQLEQVLLNLLINAIDAMEEGegGRITISTRREGDYVVISVRDNG 299
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 518245522 534 MGIPQENVERIFDRFY---RVDRararsmgGSGLGLAIAREMIEAHGGAIWAESEEGYGTTIFFTLPI 598
Cdd:COG4191 300 PGIPPEVLERIFEPFFttkPVGK-------GTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPL 360
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
370-598 |
8.37e-35 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 135.46 E-value: 8.37e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 370 QEKIDM-ERREF----VANVSHELRTPLTTMRSYLEALADGAWQ-DRELAPS----FLNVTQTETERMIRLVNDLLQLSK 439
Cdd:PRK09303 139 QENETLlEQLKFkdrvLAMLAHDLRTPLTAASLALETLELGQIDeDTELKPAlieqLQDQARRQLEEIERLITDLLEVGR 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 440 mdSRSSDL--NKELVEFNKFFNRIIDRFEMS-RSQDVHFLRLLPEAQYFVEIDTDKLTQVIDNIISNALKYSPDGGNIRF 516
Cdd:PRK09303 219 --TRWEALrfNPQKLDLGSLCQEVILELEKRwLAKSLEIQTDIPSDLPSVYADQERIRQVLLNLLDNAIKYTPEGGTITL 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 517 GCI------VQggllkAMISDDGMGIPQENVERIFDRFYRVDRARARSmgGSGLGLAIAREMIEAHGGAIWAESEEGYGT 590
Cdd:PRK09303 297 SMLhrttqkVQ-----VSICDTGPGIPEEEQERIFEDRVRLPRDEGTE--GYGIGLSVCRRIVRVHYGQIWVDSEPGQGS 369
|
....*...
gi 518245522 591 TIFFTLPI 598
Cdd:PRK09303 370 CFHFTLPV 377
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
493-596 |
1.02e-34 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 126.56 E-value: 1.02e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 493 LTQVIDNIISNALKYSPDGGNIRFGCIVQGGLLKAMISDDGMGIPQENVERIFDRFYRVDRARARsmGGSGLGLAIAREM 572
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREG--GGTGLGLAIVRRI 78
|
90 100
....*....|....*....|....
gi 518245522 573 IEAHGGAIWAESEEGYGTTIFFTL 596
Cdd:cd00075 79 VEAHGGRITVESEPGGGTTFTVTL 102
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
9-597 |
3.60e-34 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 136.31 E-value: 3.60e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 9 SIHVKFVLVYILLIVIAMQIIGLYFARELEDTLKDSFIESIQQRVDLLEFSMRAEI-IKKRGEEDPTIEQSLRT---VLY 84
Cdd:NF040691 4 SLQLRVVAITLLLSLVVILVLGVVLALQITNGLLDNRVDAALGDSRRARTQAQSQLnASDASTSDSAQQLLRTTllsVLA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 85 SVRSEDINEIRVV-------DTNFRILATSDTNKQSIVGQRsmdtnVRRSISS-ETPFNTIKVDLQKKD----RIWVLAS 152
Cdd:NF040691 84 SASGAMQGAFDVVllvpgddPSGLGPRASGSVGLVSQIPEE-----LREAVAGgQVAQQYQSVALPSGDgssaPALVVGT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 153 PIIYQGEVLGAIYLESNIETVFEQMSEI-NLILAGGtamsLAITVILGiLIAQTITR----PISDMRRQAQAMAKGNFSR 227
Cdd:NF040691 159 PVTLPVAGNYELYLLFPLEDEQSTLALVrGTLLLGG----LALVVLLG-LIAWLVTRqvvaPVRSAARTAERFAAGDLSE 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 228 KVRVYGNDEIGQLAIAFNHLTNRLQEAqsttegerrklasvlsnmtdgviatdrkgrimlINEtalrllkvprelvmhrp 307
Cdd:NF040691 234 RMPVKGEDDLARLARSFNQMADSLQRQ---------------------------------IRQ----------------- 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 308 isvvlgidseytFEDLIHMKdsinldfsspernyilrvnfsviqketgfvngiisvlhdnteqekidmerREFVANVSHE 387
Cdd:NF040691 264 ------------LEELSRLQ--------------------------------------------------QRFVSDVSHE 281
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 388 LRTPLTTMRSYLEALADgawQDRELAPSFLNVT---QTETERMIRLVNDLLQLSKMDSRSSDLNKELVEFNKFFNRIIDR 464
Cdd:NF040691 282 LRTPLTTIRMAADVIHD---SRDDFDPATARSAellHTELDRFESLLSDLLEISRFDAGAAELDVEPVDLRPLVRRVVDA 358
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 465 FE-MSRSQDVhFLRL-LPEAQYFVEIDTDKLTQVIDNIISNALKYSpDGGNIRFGCIVQGGLLKAMISDDGMGIPQENVE 542
Cdd:NF040691 359 LRqLAERAGV-ELRVdAPGTPVVAEVDPRRVERVLRNLVVNAIEHG-EGKPVVVTVAQDDTAVAVTVRDHGVGLKPGEVA 436
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*
gi 518245522 543 RIFDRFYRVDRARARSMGGSGLGLAIAREMIEAHGGAIWAESEEGYGTTIFFTLP 597
Cdd:NF040691 437 LVFDRFWRADPARARTTGGTGLGLAIALEDARLHGGWLEAWGRPGQGSQFRLTLP 491
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
488-599 |
7.56e-34 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 124.68 E-value: 7.56e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 488 IDTDKLTQVIDNIISNALKYSPDGGNIRFGCIVQGGLLKAMISDDGMGIPQENVERIFDRFYRVDrARARSMGGSGLGLA 567
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTD-KRSRKIGGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|..
gi 518245522 568 IAREMIEAHGGAIWAESEEGYGTTIFFTLPIE 599
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGGTTFTITLPLE 111
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
232-598 |
3.33e-32 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 130.24 E-value: 3.33e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 232 YGNDEIGQLAIAFNHLTNRLQEAqstTEGERRKLASVLSNMTDGVIATDRKGRIMLINETALRLLKVPRELVMHRPISVV 311
Cdd:COG5805 129 NQNGQAAILALRDITKKKKIEEI---LQEQEERLQTLIENSPDLICVIDTDGRILFINESIERLFGAPREELIGKNLLEL 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 312 LgidseyTFEDLIHMKDSIN---------------LDFSspERNYILRVNFSVIQKETGFVNGIISVLHDNTEQEKIDME 376
Cdd:COG5805 206 L------HPCDKEEFKERIEsitevwqefiiereiITKD--GRIRYFEAVIVPLIDTDGSVKGILVILRDITEKKEAEEL 277
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 377 RR---------EFVANVSHELRTPLTTMRSYLEALADGAWQDRElapsFLNVTQTETERMIRLVNDLLQLSKMDSrssdL 447
Cdd:COG5805 278 MArseklsiagQLAAGIAHEIRNPLTSIKGFLQLLQPGIEDKEE----YFDIMLSELDRIESIISEFLALAKPQA----V 349
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 448 NKELVEFNKFFNRIIDRFEM-SRSQDVHFLRLLPEAQYFVEIDTDKLTQVIDNIISNALKYSPDGGNIRFGCIVQGGLLK 526
Cdd:COG5805 350 NKEKENINELIQDVVTLLETeAILHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVI 429
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518245522 527 AMISDDGMGIPQENVERIFDRFYRVDRArarsmgGSGLGLAIAREMIEAHGGAIWAESEEGYGTTIFFTLPI 598
Cdd:COG5805 430 IRVIDEGIGIPEERLKKLGEPFFTTKEK------GTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPL 495
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
381-598 |
2.13e-31 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 127.36 E-value: 2.13e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 381 VANVSHELRTPLTTMRsyleaLADGAWQDRELAPSFLNVTQTETERMIRLVNDLLQLSKMDSRSsDLNKELVEFNKFFNR 460
Cdd:PRK09470 247 LSDISHELRTPLTRLQ-----LATALLRRRQGESKELERIETEAQRLDSMINDLLVLSRNQQKN-HLERETFKANSLWSE 320
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 461 IID--RFEMSRSQDVHFLRLLPEaQYFVEIDTDKLTQVIDNIISNALKYSPDGGNIRFGCIVQGglLKAMISDDGMGIPQ 538
Cdd:PRK09470 321 VLEdaKFEAEQMGKSLTVSAPPG-PWPINGNPNALASALENIVRNALRYSHTKIEVAFSVDKDG--LTITVDDDGPGVPE 397
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 539 ENVERIFDRFYRVDRARARSMGGSGLGLAIAREMIEAHGGAIWAESEEGYGTTIFFTLPI 598
Cdd:PRK09470 398 EEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLPL 457
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
489-599 |
1.32e-30 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 115.54 E-value: 1.32e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 489 DTDKLTQVIDNIISNALKYSPDGGNIRFgCIVQGGLLKAMISDDGMGIPQENVERIFDRFYRVDRaraRSMGGSGLGLAI 568
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAGEITV-TLSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGLSI 77
|
90 100 110
....*....|....*....|....*....|.
gi 518245522 569 AREMIEAHGGAIWAESEEGYGTTIFFTLPIE 599
Cdd:pfam02518 78 VRKLVELLGGTITVESEPGGGTTVTLTLPLA 108
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-597 |
2.19e-29 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 112.03 E-value: 2.19e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 493 LTQVIDNIISNALKYSPdgGNIRFGCIVQGGLLKAMISDDGMGIPQENVERIFDRFYRVDRARARSMGGSGLGLAIAREM 572
Cdd:cd16949 1 LARALENVLRNALRYSP--SKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERA 78
|
90 100
....*....|....*....|....*
gi 518245522 573 IEAHGGAIWAESEEGYGTTIFFTLP 597
Cdd:cd16949 79 IEQHGGKIKASNRKPGGLRVRIWLP 103
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
377-601 |
2.28e-29 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 120.86 E-value: 2.28e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 377 RREFVANVSHELRTPLTTMRsYLEALADGAWQDRELApsfLN--VTQTETermirLVNDLLQLSKMDSRSSDLNKELVEF 454
Cdd:PRK10604 212 KKQLIDGIAHELRTPLVRLR-YRLEMSDNLSAAESQA---LNrdIGQLEA-----LIEELLTYARLDRPQNELHLSEPDL 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 455 NKFFNRIIDRFEMSRSQDVHFLRLLPEAQYFVeIDTDKLTQVIDNIISNALKYSpdGGNIRFGCIVQGGLLKAMISDDGM 534
Cdd:PRK10604 283 PAWLSTHLADIQAVTPEKTVRLDTPHQGDYGA-LDMRLMERVLDNLLNNALRYA--HSRVRVSLLLDGNQACLIVEDDGP 359
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518245522 535 GIPQENVERIFDRFYRVDRARARSMGGSGLGLAIAREMIEAHGGAIWAESEEGYGTTIFFTLPIELD 601
Cdd:PRK10604 360 GIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWPVWHN 426
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
368-605 |
5.58e-29 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 122.84 E-value: 5.58e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 368 TEQEKIDMERRE----FVANVSHELRTPLTTMRSYLEAL-----ADG---AWQDRELAPSFLNVTqtetermiRLVNDLL 435
Cdd:PRK10490 651 EEQARLASEREQlrnaLLAALSHDLRTPLTVLFGQAEILtldlaSEGsphARQASEIRQQVLNTT--------RLVNNLL 722
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 436 QLSKMDSRSSDLNKELVEFNKFFNRIIDRFEMSRSQdvHFLRL-LPEAQYFVEIDTDKLTQVIDNIISNALKYSPDGGNI 514
Cdd:PRK10490 723 DMARIQSGGFNLRKEWLTLEEVVGSALQMLEPGLSG--HPINLsLPEPLTLIHVDGPLFERVLINLLENAVKYAGAQAEI 800
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 515 RFGCIVQGGLLKAMISDDGMGIPQENVERIFDRFYRVDRARArsMGGSGLGLAIAREMIEAHGGAIWAESEEGYGTTIFF 594
Cdd:PRK10490 801 GIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESA--IPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRV 878
|
250
....*....|....*
gi 518245522 595 TLPI----ELDEAGE 605
Cdd:PRK10490 879 TLPLetppELEEFHE 893
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
151-598 |
1.31e-28 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 119.18 E-value: 1.31e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 151 ASPIIYQGEVLGAIylesnieTV---------FEQMSEINLILAGgtAMSLAITVILGILIAQTITRPISDMRRQAQAMA 221
Cdd:PRK11100 151 AAPIRDGGRIIGVL-------SVgkpnssmapFIKRSERRILWAG--ALLLGIALLIGAGVVWWLNRSIRRLTRYADAVT 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 222 KGnfsRKVRV--YGNDEIGQLAIAFNHLTNRLqeaqsttEGerrklasvlsnmtdgviatdrkgrimlinetalrllkvp 299
Cdd:PRK11100 222 EG---KPVPLpkLGSSELRELAQALESMRVKL-------EG--------------------------------------- 252
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 300 relvmhrpisvvlgidseytfedlihmkdsinldfsspeRNYIlrvnfsviqketgfvngiisvlhdntEQekidmerre 379
Cdd:PRK11100 253 ---------------------------------------KAYV--------------------------EQ--------- 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 380 FVANVSHELRTPLTTMRSYLEALADGAWQDRelAPSFLNVTQTETERMIRLVNDLLQLSKMDSRSSDLNKELVEFNKFFN 459
Cdd:PRK11100 259 YVQTLTHELKSPLAAIRGAAELLQEDPPPED--RARFTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLE 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 460 RIIDRFEMSRSQ-DVHfLRLLPEAQYfVEIDTDKLTQVIDNIISNALKYSPDGGNIRFGCIVQGGLLKAMISDDGMGIPQ 538
Cdd:PRK11100 337 ELVEAREAQAAAkGIT-LRLRPDDAR-VLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPD 414
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 518245522 539 ENVERIFDRFY---RVDRARArsmgGSGLGLAIAREMIEAHGGAIWAESEEGYGTTIFFTLPI 598
Cdd:PRK11100 415 YALPRIFERFYslpRPANGRK----STGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPR 473
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
363-597 |
4.56e-28 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 117.95 E-value: 4.56e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 363 VLHDNTEQEKI-DMERRE--FVANVSHELRTPLTTMRSYLEALADGAWQDRELApSFLNVTQTETERMIRLVNDLLQLSK 439
Cdd:PRK09835 245 VLSFNHMIERIeDVFTRQsnFSADIAHEIRTPITNLITQTEIALSQSRSQKELE-DVLYSNLEELTRMAKMVSDMLFLAQ 323
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 440 MDSRSSDLNKELVEFNKFFNRIIDRFEMSRSQDVHFLRLLPEAqYFVEIDTDKLTQVIDNIISNALKYSPDGGNIRFGCI 519
Cdd:PRK09835 324 ADNNQLIPEKKMLDLADEVGKVFDFFEAWAEERGVELRFVGDP-CQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQ 402
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 518245522 520 VQGGLLKAMISDDGMGIPQENVERIFDRFYRVDRARARSMGGSGLGLAIAREMIEAHGGAIWAESeEGYGTTIFFTLP 597
Cdd:PRK09835 403 EVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTS-DARGTRFVISLP 479
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
489-597 |
1.31e-27 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 107.16 E-value: 1.31e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 489 DTDKLTQVIDNIISNALKYSPDGGNIRFGCIVQGGLLKAMISDDGMGIPQENVERIFDRFYRVDRARARSMGGSGLGLAI 568
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 518245522 569 AREMIEAHGGAIWAESEEGYGTTIFFTLP 597
Cdd:cd16946 81 CHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
493-597 |
2.66e-27 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 106.04 E-value: 2.66e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 493 LTQVIDNIISNALKYSPDGGNI----RFGCIVQGGLLKAMISDDGMGIPQENVERIFDRFYRVDRARARSMGGSGLGLAI 568
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEGEVTlrvsLEEEEEDGVQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 518245522 569 AREMIEAHGGAIWAESEEGYGTTIFFTLP 597
Cdd:cd16922 81 SKKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
374-598 |
4.00e-27 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 114.88 E-value: 4.00e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 374 DMERRE-------FVANVSHELRTPLTTMR---SYLEALADGAWQDRELApsflNVTQTETERMIRLVNDLLQLSkmdsR 443
Cdd:PRK10364 227 EMKRKEklvalghLAAGVAHEIRNPLSSIKglaKYFAERAPAGGEAHQLA----QVMAKEADRLNRVVSELLELV----K 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 444 SSDLNKELVEFNKFFN---RIIDRFEMSRSQDVHFL--RLLPEAQyfveIDTDKLTQVIDNIISNALKYSPDGGNIRFGC 518
Cdd:PRK10364 299 PTHLALQAVDLNDLINhslQLVSQDANSREIQLRFTanDTLPEIQ----ADPDRLTQVLLNLYLNAIQAIGQHGVISVTA 374
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 519 IVQGGLLKAMISDDGMGIPQENVERIFDRFYRVDRArarsmgGSGLGLAIAREMIEAHGGAIWAESEEGYGTTIFFTLPI 598
Cdd:PRK10364 375 SESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAE------GTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPV 448
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
369-599 |
6.13e-27 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 116.42 E-value: 6.13e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 369 EQEKIDMERREFVANVSHELRTPLTTMRSYLEALadgawQDRELAPS---FLNVTQTETERMIRLVNDLLQLSKMDSRSS 445
Cdd:TIGR02956 456 EAEEANRAKSAFLATMSHEIRTPLNGILGTLELL-----GDTGLTSQqqqYLQVINRSGESLLDILNDILDYSKIEAGHL 530
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 446 DLNKELVEFNKFFNRIIDRFEmSRSQD------VHFLRLLPEaqyFVEIDTDKLTQVIDNIISNALKYSPDGG-NIRFGC 518
Cdd:TIGR02956 531 SISPRPFDLNALLDDVHHLMV-SRAQLkgiqlrLNIPEQLPN---WWQGDGPRIRQVLINLVGNAIKFTDRGSvVLRVSL 606
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 519 IVQGGLLKAMIsDDGMGIPQENVERIFDRFYRVDraRARSMGGSGLGLAIAREMIEAHGGAIWAESEEGYGTTIFFTLPI 598
Cdd:TIGR02956 607 NDDSSLLFEVE-DTGCGIAEEEQATLFDAFTQAD--GRRRSGGTGLGLAISQRLVEAMDGELGVESELGVGSCFWFTLPL 683
|
.
gi 518245522 599 E 599
Cdd:TIGR02956 684 T 684
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
359-600 |
3.53e-25 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 110.80 E-value: 3.53e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 359 GIISVLHDNTE----QEKIDMERRE---FVANVSHELRTPLTTM----RSYLealadgawqDRELAPSFLNVTQTETERM 427
Cdd:PRK11091 258 GLMGFGRDITErkryQDALEKASRDkttFISTISHELRTPLNGIvglsRILL---------DTELTAEQRKYLKTIHVSA 328
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 428 IRL---VNDLLQLSKMDSRSSDLNKELVEFNKFFNRIID-----------RFEMSRSQDvhflrlLPEaqyFVEIDTDKL 493
Cdd:PRK11091 329 ITLgniFNDIIDMDKMERRKLQLDNQPIDFTDFLADLENlsglqaeqkglRFDLEPLLP------LPH---KVITDGTRL 399
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 494 TQVIDNIISNALKYSPDGGnIRFGCIVQGG-LLKAMISDDGMGIPQENVERIFDRFYRV-DRARARSMGGSGLGLAIARE 571
Cdd:PRK11091 400 RQILWNLISNAVKFTQQGG-VTVRVRYEEGdMLTFEVEDSGIGIPEDELDKIFAMYYQVkDSHGGKPATGTGIGLAVSKR 478
|
250 260
....*....|....*....|....*....
gi 518245522 572 MIEAHGGAIWAESEEGYGTTifFTLPIEL 600
Cdd:PRK11091 479 LAQAMGGDITVTSEEGKGSC--FTLTIHA 505
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-597 |
1.97e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 97.78 E-value: 1.97e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 493 LTQVIDNIISNALKYSPDG--GNIRFGCIVQGGLLKAMISDDGMGIPQENVERIFDRFYRVDRARArsMGGSGLGLAIAR 570
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRrpPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSREE--YEGTGVGLAIVR 78
|
90 100
....*....|....*....|....*..
gi 518245522 571 EMIEAHGGAIWAESEEGYGTTIFFTLP 597
Cdd:cd16921 79 KIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
489-597 |
3.22e-24 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 97.56 E-value: 3.22e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 489 DTDKLTQVIDNIISNALKYSPDGGNIRfgCIVQ---GGLLKAMISDDGMGIPQENVERIFDRFYRVDRARARSMGGSGLG 565
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIR--CILEkfrLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLG 78
|
90 100 110
....*....|....*....|....*....|..
gi 518245522 566 LAIAREMIEAHGGAIWAESEEGYGTTIFFTLP 597
Cdd:cd16925 79 LSIVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
382-580 |
6.34e-24 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 103.54 E-value: 6.34e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 382 ANVSHELRTPLTTMRSYLEALADGAWQ-DRELAPSFLNvtqtETERMIRLVNDLLQLSKMDSRSSDLNKELVEFNKFFNR 460
Cdd:NF012226 143 AAIAHELRTPITILQGRLQGILDGVFEpDPALFKSLLN----QVEGLSHLVEDLRTLSLVENQQLRLNYESVDLKDSIEK 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 461 IIDRFEmSRSQDVHFLRLLPEAQYFVEIDTDKLTQVIDNIISNALKYSpDGGNIRFGCIVQGGLLKAMISDDGMGIPQEN 540
Cdd:NF012226 219 VLKMFE-DRLEQAQLTIVLNLTATPVFCDRRRIEQVLIALIDNAIRYA-NAGKLKISSSVIQDDWILQIEDEGPGIAEEY 296
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 518245522 541 VERIFDRFYRVDRARARSMGGSGLGLAIAREMIEAHGGAI 580
Cdd:NF012226 297 QQDLFNPFFRLEQSRNKEFGGTGLGLAVVHAIVIAHKGSI 336
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
377-600 |
7.34e-24 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 107.13 E-value: 7.34e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 377 RREFVANVSHELRTPLTTMRSYLEALAdGAWQDRELAPSFLNVTQTETERMIRLVNDLLQLSKMDSRSSDLNKELVEFNK 456
Cdd:PRK09959 712 KSQFLATMSHEIRTPISSIMGFLELLS-GSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWVDIPT 790
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 457 FFNRIIDRF---EMSRSQDVHFLRLLPEaQYFVEIDTDKLTQVIDNIISNALKYSPDGGNIRFGCIVQ----GGLLKAMI 529
Cdd:PRK09959 791 LVQNTCHSFgaiAASKSIALSCSSTFPD-HYLVKIDPQAFKQVLSNLLSNALKFTTEGAVKITTSLGHiddnHAVIKMTI 869
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 518245522 530 SDDGMGIPQENVERIFDRFYRVDRARARSmgGSGLGLAIAREMIEAHGGAIWAESEEGYGTTIFFTLPIEL 600
Cdd:PRK09959 870 MDSGSGLSQEEQQQLFKRYSQTSAGRQQT--GSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPVEI 938
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-597 |
3.11e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 91.88 E-value: 3.11e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 493 LTQVIDNIISNALKYSPDGGNI--RFGCIVQGGLLKamISDDGMGIPQENVERIFDRFYRVDRARARSMGGSGLGLAIAR 570
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTItvRWSQEESGARLS--VEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVK 78
|
90 100
....*....|....*....|....*..
gi 518245522 571 EMIEAHGGAIWAESEEGYGTTIFFTLP 597
Cdd:cd16952 79 HVMSRHDARLLIASELGKGSRFTCLFP 105
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-586 |
6.65e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 91.09 E-value: 6.65e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 493 LTQVIDNIISNALKYSP-DGGNIRFGCIVQGGLLKAMISDDGMGIPQENVERIFDRFYrVDRARARSMG-GSGLGLAIAR 570
Cdd:cd16953 1 LGQVLRNLIGNAISFSPpDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFY-TERPANEAFGqHSGLGLSISR 79
|
90
....*....|....*.
gi 518245522 571 EMIEAHGGAIWAESEE 586
Cdd:cd16953 80 QIIEAHGGISVAENHN 95
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-590 |
8.93e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 87.44 E-value: 8.93e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 493 LTQVIDNIISNALKYSPDGGNIRFGCIVQGGLLKAMISDDGMGIPQENVERIFDRFYRVDraRARSMGGSGLGLAIAREM 572
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGD--NSRNTEGAGLGLSIAKAI 78
|
90
....*....|....*...
gi 518245522 573 IEAHGGAIWAESEEGYGT 590
Cdd:cd16923 79 IELHGGSASAEYDDNHDL 96
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-597 |
3.51e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 85.94 E-value: 3.51e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 493 LTQVIDNIISNALKYSPDggNIRFGCIVQGGLLKAMISDDGMGIPQENVERIFDRFYRVDRARARSMGGSGLGLAIAREM 572
Cdd:cd16939 1 MARALDNLLRNALRYAHR--TVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRV 78
|
90 100
....*....|....*....|....*
gi 518245522 573 IEAHGGAIWAESEEGYGTTIFFTLP 597
Cdd:cd16939 79 ALWHGGHVECDDSELGGACFRLTWP 103
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
237-601 |
4.84e-20 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 92.60 E-value: 4.84e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 237 IGQLAIAFNHLTNRLQEAQSTTEGERRKLASVLSNMTDGVIATDRKGRIMLINETALRLLKVPrelVMHRPISVVLGIDS 316
Cdd:COG3290 58 LILLLLLLLLLAALLLKLLEEIARLVEEREAVLESIREGVIAVDRDGRITLINDAARRLLGLD---AIGRPIDEVLAEVL 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 317 EYTFEDLIHMKdsinldfsspeRNYILRVNFSVIQKEtGFVNGIISVLHDNTEQEKIDMErrefvanvshelrtpLTTMR 396
Cdd:COG3290 135 ETGERDEEILL-----------NGRVLVVNRVPIRDD-GRVVGAVATFRDRTELERLEEE---------------LEGVK 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 397 SYLEALadgawqdRELAPSFLNVTQTetermirlVNDLLQLSKMDSRSSDLNKELVEFNKFFNRIIDRFE---------- 466
Cdd:COG3290 188 ELAEAL-------RAQRHDFRNHLHT--------ISGLLQLGEYDEALEYIDEISEELQELIDSLLSRIGnpvlaalllg 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 467 -MSRSQ------DVHFLRLLPEAqyfvEIDTDKLTQVIDNIISNAL----KYSPDGGNIRFGCIVQGGLLKAMISDDGMG 535
Cdd:COG3290 253 kAARARergidlTIDIDSDLPDL----PLSDTDLVTILGNLLDNAIeaveKLPEEERRVELSIRDDGDELVIEVEDSGPG 328
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518245522 536 IPQENVERIFDRFYRVDRArarsmGGSGLGLAIAREMIEAHGGAIWAESEEGYGTTIFFTLPIELD 601
Cdd:COG3290 329 IPEELLEKIFERGFSTKLG-----EGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEGE 389
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
490-597 |
6.29e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 82.33 E-value: 6.29e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 490 TDK--LTQVIDNIISNALKYSPDGGNIRFGCIVQGGLLKAMISDDGMGIPQENVERIFDRFY--RVDRARARSmggSGLG 565
Cdd:cd16948 1 TDAkwLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFtgENGRNFQES---TGMG 77
|
90 100 110
....*....|....*....|....*....|..
gi 518245522 566 LAIAREMIEAHGGAIWAESEEGYGTTIFFTLP 597
Cdd:cd16948 78 LYLVKKLCDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
369-599 |
8.79e-19 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 90.86 E-value: 8.79e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 369 EQEKIDMERREFVANVSHELRTPLTTMRSYLEALadgawQDRELAPSFLNVTQTE---TERMIRLVNDLLQLSKMDSRSS 445
Cdd:PRK15347 390 RAEQANKRKSEHLTTISHEIRTPLNGVLGALELL-----QNTPLTAEQMDLADTArqcTLSLLAIINNLLDFSRIESGQM 464
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 446 DLNKELVEFNKffnrIIDRfEM----SRSQDVHF-LRLLPEAQYFVEIDTD--KLTQVIDNIISNALKYSPDGGnIRFGC 518
Cdd:PRK15347 465 TLSLEETALLP----LLDQ-AMltiqGPAQSKSLtLRTFVGAHVPLYLHLDslRLRQILVNLLGNAVKFTETGG-IRLRV 538
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 519 IVQGGLLKAMISDDGMGIPQENVERIFDRFYRVDraraRSMGGSGLGLAIAREMIEAHGGAIWAESEEGYGTTIFFTLPI 598
Cdd:PRK15347 539 KRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQAD----THSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLPL 614
|
.
gi 518245522 599 E 599
Cdd:PRK15347 615 N 615
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
378-597 |
3.31e-18 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 88.65 E-value: 3.31e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 378 REFVANVSHELRTPLTTMRSYLEALADGawQDRELAPSFLNVTQTETERMIRLVNDLLQLSKMDSRSSDLNKELVEFNKF 457
Cdd:TIGR03785 486 ENMSSRLSHELRTPVAVVRSSLENLELQ--ALEQEKQKYLERAREGTERLSMILNNMSEATRLEQAIQSAEVEDFDLSEV 563
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 458 FNRIIDRFEMsrsqdvhflrLLPEAQYFVEIDTDKLT---------QVIDNIISNALKYSPDGGNIRFGCIVQGGLLKAM 528
Cdd:TIGR03785 564 LSGCMQGYQM----------TYPPQRFELNIPETPLVmrgspeliaQMLDKLVDNAREFSPEDGLIEVGLSQNKSHALLT 633
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 529 ISDDGMGIPQENVERIFDRFYRVDRARARSMGGSGLGLAIAREMIEAHGGAIWAES-EEGYGTTIFFTLP 597
Cdd:TIGR03785 634 VSNEGPPLPEDMGEQLFDSMVSVRDQGAQDQPHLGLGLYIVRLIADFHQGRIQAENrQQNDGVVFRISLP 703
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
489-592 |
3.34e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 77.45 E-value: 3.34e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 489 DTDKLTQVIDNIISNALKYSPDGGNIRfgcIVQGGLLKAM--ISDDGMGIPQENVERIFDRFYRVDrarARSMGGSGLGL 566
Cdd:cd16940 10 DALLLFLLLRNLVDNAVRYSPQGSRVE---IKLSADDGAVirVEDNGPGIDEEELEALFERFYRSD---GQNYGGSGLGL 83
|
90 100
....*....|....*....|....*.
gi 518245522 567 AIAREMIEAHGGAIWAESEEGYGTTI 592
Cdd:cd16940 84 SIVKRIVELHGGQIFLGNAQGGGLEA 109
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
380-600 |
3.93e-17 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 85.41 E-value: 3.93e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 380 FVANVSHELRTPLTTMRSYLEALadgawQDREL---APSFLNVTQTETERMIRLVNDLLQLSKMDSRSsdLNKELVEFN- 455
Cdd:PRK10841 450 FLATVSHELRTPLYGIIGNLDLL-----QTKELpkgVDRLVTAMNNSSSLLLKIISDILDFSKIESEQ--LKIEPREFSp 522
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 456 -KFFNRIIDrfemsrsqdvHFLRLLPEAQ---Y-FVE------IDTD--KLTQVIDNIISNALKYSpDGGNIRFGCIVQG 522
Cdd:PRK10841 523 rEVINHITA----------NYLPLVVKKRlglYcFIEpdvpvaLNGDpmRLQQVISNLLSNAIKFT-DTGCIVLHVRVDG 591
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 518245522 523 GLLKAMISDDGMGIPQENVERIFDRFYRVDRARARSMGGSGLGLAIAREMIEAHGGAIWAESEEGYGTTifFTLPIEL 600
Cdd:PRK10841 592 DYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMDGDISVDSEPGMGSQ--FTIRIPL 667
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
376-442 |
4.75e-17 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 75.71 E-value: 4.75e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518245522 376 ERREFVANVSHELRTPLTTMRSYLEALADgaWQDRELAPSFLNVTQTETERMIRLVNDLLQLSKMDS 442
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRD--EKLDEEQREYLETILRSAERLLRLINDLLDLSRIEA 65
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
376-599 |
6.84e-17 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 83.42 E-value: 6.84e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 376 ERREFVANVSHELRTPLTTMRsylealadgawqdreLApsflnvtqteTERMirlvndllqlSKMDSRSSD-LNKELVEF 454
Cdd:PRK09467 228 DRTLLMAGVSHDLRTPLTRIR---------------LA----------TEMM----------SEEDGYLAEsINKDIEEC 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 455 NKffnrIIDRF--------EMSRSQ-DVHFL---RLLPEAQYFVEIDTD-------------KLTQVIDNIISNALKYSp 509
Cdd:PRK09467 273 NA----IIEQFidylrtgqEMPMEMaDLNALlgeVIAAESGYEREIETAlqpgpievpmnpiAIKRALANLVVNAARYG- 347
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 510 dGGNIRFGCIVQGGLLKAMISDDGMGIPQENVERIFDRFYRVDRARARSmgGSGLGLAIAREMIEAHGGAI-WAESEEGy 588
Cdd:PRK09467 348 -NGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARGSS--GTGLGLAIVKRIVDQHNGKVeLGNSEEG- 423
|
250
....*....|.
gi 518245522 589 GTTIFFTLPIE 599
Cdd:PRK09467 424 GLSARAWLPLT 434
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
369-598 |
1.04e-16 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 84.19 E-value: 1.04e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 369 EQEKIDMERREFVANVSHELRTPLTTMRSYLEALADgawqdRELAPSFLNVTQTET---ERMIRLVNDLLQLSKMDSRSS 445
Cdd:PRK11466 436 EAEKASQAKSAFLAAMSHEIRTPLYGILGTAQLLAD-----NPALNAQRDDLRAITdsgESLLTILNDILDYSAIEAGGK 510
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 446 D--LNKELVEFNKFFNRIIdRFEMSRSQ------DVHFLRLLPEAqyfVEIDTDKLTQVIDNIISNALKYSpDGGNIRFG 517
Cdd:PRK11466 511 NvsVSDEPFEPRPLLESTL-QLMSGRVKgrpirlATDIADDLPTA---LMGDPRRIRQVITNLLSNALRFT-DEGSIVLR 585
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 518 CIVQGGLLKAMISDDGMGIPQENVERIFDRFYRVDRARarsmGGSGLGLAIAREMIEAHGGAIWAESEEGYGTTIFFTLP 597
Cdd:PRK11466 586 SRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLP 661
|
.
gi 518245522 598 I 598
Cdd:PRK11466 662 L 662
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-597 |
2.68e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 74.74 E-value: 2.68e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 493 LTQVIDNIISNALKYSPDGGNIRFGCIVQ-----GGLLKAMISDDGMGIPQENVERIFDRFYRVDRArarsmgGSGLGLA 567
Cdd:cd16920 1 IQQVLINLVRNGIEAMSEGGCERRELTIRtspadDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSE------GLGMGLS 74
|
90 100 110
....*....|....*....|....*....|
gi 518245522 568 IAREMIEAHGGAIWAESEEGYGTTIFFTLP 597
Cdd:cd16920 75 ICRSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
376-442 |
3.72e-16 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 72.98 E-value: 3.72e-16
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518245522 376 ERREFVANVSHELRTPLTTMRSYLEALADGAWQDRELApsFLNVTQTETERMIRLVNDLLQLSKMDS 442
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQRE--YLETILREAERLLRLINDLLDLSRIEA 65
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
489-583 |
3.87e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 74.42 E-value: 3.87e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 489 DTDKLTQVIDNIISNALKYSPDGGNIRFGCIVQGGLLKAMISDDGMGIPQENVERIFDRFYRVDRARaRSMGGSGLGLAI 568
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSR-RSGGHYGMGLYI 79
|
90
....*....|....*
gi 518245522 569 AREMIEAHGGAIWAE 583
Cdd:cd16975 80 AKNLVEKHGGSLIIE 94
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
479-593 |
4.15e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 74.86 E-value: 4.15e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 479 LPEAQYFVEIDTDKLTQVIDNIISNALKYSPDGGNIRFGCIVQGGLLKAMISDDGMGIPQENVERIFDRFYRVDRARARS 558
Cdd:cd16947 7 IPDRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSA 86
|
90 100 110
....*....|....*....|....*....|....*
gi 518245522 559 MGGSGLGLAIAREMIEAHGGAIWAESEEgYGTTIF 593
Cdd:cd16947 87 KQGNGLGLTITKRLAESMGGSIYVNSKP-YEKTVF 120
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-597 |
5.19e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 73.64 E-value: 5.19e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 493 LTQVIDNIISNALKYSpdGGNIRFGCIVQGGLLKAMISDDGMGIPQENVERIFDRFYRVDraRARSMGGSGLGLAIAREM 572
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGD--NARGTSGTGLGLAIVQRI 76
|
90 100
....*....|....*....|....*
gi 518245522 573 IEAHGGAIWAESEEGYGTTIFFTLP 597
Cdd:cd16950 77 SDAHGGSLTLANRAGGGLCARIELP 101
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
376-577 |
6.94e-16 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 80.46 E-value: 6.94e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 376 ERReFVANVSHELRTPLTTMRSYLEA--LADGAWQDRELApsflnVTQTET--ERMIRLVNDLLQLSKMDSRSSDLNKEL 451
Cdd:PRK10337 237 ERR-FTSDAAHELRSPLAALKVQTEVaqLSDDDPQARKKA-----LLQLHAgiDRATRLVDQLLTLSRLDSLDNLQDVAE 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 452 VEFNKFFNR-IIDRFEMSRSQDVHfLRLLPEAQYFveIDTDK---LTQVIDNIISNALKYSPDGGNIRFgcIVQGGLLKa 527
Cdd:PRK10337 311 IPLEDLLQSaVMDIYHTAQQAGID-VRLTLNAHPV--IRTGQpllLSLLVRNLLDNAIRYSPQGSVVDV--TLNARNFT- 384
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 518245522 528 mISDDGMGIPQENVERIFDRFYrvdRARARSMGGSGLGLAIAREMIEAHG 577
Cdd:PRK10337 385 -VRDNGPGVTPEALARIGERFY---RPPGQEATGSGLGLSIVRRIAKLHG 430
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
269-602 |
7.04e-16 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 80.73 E-value: 7.04e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 269 LSNMTDGVIATDRKGRIMLINETALRLLKvPRELVMHRPIsvvlGIDSEYtFEDLIHMKDSinLDFSSPERNYILRVNFS 348
Cdd:PRK11086 227 LQSIKEGVIAVDDRGEVTLINDEAKRLFN-YKKGLEDDPL----GTDVES-WMPVSRLKEV--LRTGTPRRDEEININGR 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 349 VIQKET------GFVNGIISVLHDNTEQEKIdMERrefvanvshelrtpLTTMRSYLEALadgawqdRELAPSFLNvtqt 422
Cdd:PRK11086 299 LLLTNTvpvrvnGEIIGAIATFRDKTEVRQL-AQR--------------LDGMVNYADAL-------RAQSHEFMN---- 352
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 423 eterMIRLVNDLLQLSKMD-----------SRSSDLNKELvefNKFFNRIIDRF---EMSRSQDVHFLRLLPEAQYFVEI 488
Cdd:PRK11086 353 ----KLHVILGLLHLKSYDqledyilktanNYQEEIGSLL---GKIKSPVIAGFllgKISRARELGITLIISEDSQLPDS 425
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 489 D----TDKLTQVIDNIISNALKY--SPDGGNIRFGCIVQGGLLKAMISDDGMGIPQENVERIFDRFYrvdrararSMGGS 562
Cdd:PRK11086 426 GdedqVHELITILGNLIENALEAvgGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGY--------STKGS 497
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 518245522 563 --GLGLAIAREMIEAHGGAIWAESEEGYGTTIFFTLPIELDE 602
Cdd:PRK11086 498 nrGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIPWDGER 539
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
374-439 |
7.15e-16 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 72.25 E-value: 7.15e-16
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518245522 374 DMERREFVANVSHELRTPLTTMRSYLEALADGAWQDRELAPsFLNVTQTETERMIRLVNDLLQLSK 439
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQRE-YLERIREEAERLLRLINDLLDLSR 65
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
379-597 |
4.01e-15 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 77.60 E-value: 4.01e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 379 EFVANVSHELRTPLTTMRSYLEaLADGAWQDRELAPSFLNVTQTETERMIRLVNDLLQLSKMDSRssdlNKELVEFNKFF 458
Cdd:COG5806 203 ELAASIAHEVRNPLTVVRGFIQ-LLQEPELSDEKRKQYIRIALEELDRAEAIITDYLTFAKPQPE----KLEKIDVSEEL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 459 NRIIDRFE-MSRSQDVHfLRLLPEAQYFVEIDTDKLTQVIDNIISNALKYSPDGGNIRFGCIVQGGLLKAMISDDGMGIP 537
Cdd:COG5806 278 EHVIDVLSpYANMNNVE-IQTELEPGLYIEGDRQKLQQCLINIIKNGIEAMPNGGTLTIDVSIDKNKVIISIKDTGVGMT 356
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 538 QENVERIFDRFYRVDRArarsmgGSGLGLAIAREMIEAHGGAIWAESEEGYGTTIFFTLP 597
Cdd:COG5806 357 KEQLERLGEPYFSTKEK------GTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITLP 410
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-592 |
1.13e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 70.18 E-value: 1.13e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 493 LTQVIDNIISNALKYSPDGGNIRFGCIVQGGLLKAMISDDGMGIPQENVERIFDRFYRVDRARA--RSmggSGLGLAIAR 570
Cdd:cd16945 5 LRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSgqKS---TGLGLAFVQ 81
|
90 100
....*....|....*....|...
gi 518245522 571 EMIEAHGGAI-WAESEEGYGTTI 592
Cdd:cd16945 82 EVAQLHGGRItLRNRPDGVLAFL 104
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
370-578 |
1.57e-14 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 75.39 E-value: 1.57e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 370 QEKIDMERrEFVANVSHELRTPLTTMRSYLEALADGAWQDrelAPSFLNvtqtETERMIRLVNDLLQLSKMDSRSSDLNK 449
Cdd:PRK10755 131 TSTLDQER-LFTADVAHELRTPLAGIRLHLELLEKQHHID---VAPLIA----RLDQMMHTVEQLLQLARAGQSFSSGHY 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 450 ELVEFNkffNRIIDRF-----EMSRSQDVHFLRLLPEAQYFVEIDTDKLTQVIDNIISNALKYSPDGGNIRFGCIVQGGL 524
Cdd:PRK10755 203 QTVKLL---EDVILPSqdelsEMLEQRQQTLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGG 279
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 518245522 525 LKAMISDDGMGIPQENVERIFDRFYRVDraraRSMGGSGLGLAIAREMIEAHGG 578
Cdd:PRK10755 280 AVLAVEDEGPGIDESKCGELSKAFVRMD----SRYGGIGLGLSIVSRITQLHHG 329
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
369-598 |
2.04e-14 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 76.64 E-value: 2.04e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 369 EQEKIDMERR-----------EFVANVSHELRTPLTTMRSYLEaLADGAWQDRELAPSFLNVTQTETERMIRLVNDLLQL 437
Cdd:PRK13837 431 ETERDALERRleharrleavgTLASGIAHNFNNILGAILGYAE-MALNKLARHSRAARYIDEIISAGARARLIIDQILAF 509
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 438 SkmdsRSSDLNKELVEFNKFFNRIIDRFEMSRSQDVHFLRLLPEAQYFVEIDTDKLTQVIDNIISNALKYSPDGGNIRF- 516
Cdd:PRK13837 510 G----RKGERNTKPFDLSELVTEIAPLLRVSLPPGVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDIs 585
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 517 --------------GCIVQGGLLKAMISDDGMGIPQENVERIFDRFYrVDRArarsmGGSGLGLAIAREMIEAHGGAIWA 582
Cdd:PRK13837 586 lsraklrapkvlshGVLPPGRYVLLRVSDTGAGIDEAVLPHIFEPFF-TTRA-----GGTGLGLATVHGIVSAHAGYIDV 659
|
250
....*....|....*.
gi 518245522 583 ESEEGYGTTIFFTLPI 598
Cdd:PRK13837 660 QSTVGRGTRFDVYLPP 675
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
379-600 |
4.42e-14 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 75.66 E-value: 4.42e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 379 EFVANVSHELRTPL------TtmrsylealadgawqdRELAPSFLNVTQTE----TER----MIRLVNDLLQLSKMDSrs 444
Cdd:PRK11107 295 EFLANMSHELRTPLngvigfT----------------RQTLKTPLTPTQRDylqtIERsannLLAIINDILDFSKLEA-- 356
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 445 sdlNKELVEFNKF-FNRIIDRFEMSRSQDVH------FLRLLPEAQYFVEIDTDKLTQVIDNIISNALKYSpDGGNIRFG 517
Cdd:PRK11107 357 ---GKLVLENIPFsLRETLDEVVTLLAHSAHekglelTLNIDPDVPDNVIGDPLRLQQIITNLVGNAIKFT-ESGNIDIL 432
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 518 CIVQGG-----LLKAMISDDGMGIPQENVERIFDRFYRVDRARARSMGGSGLGLAIAREMIEAHGGAIWAESEEGYGTTI 592
Cdd:PRK11107 433 VELRALsntkvQLEVQIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQKLVNEMGGDISFHSQPNRGSTF 512
|
....*...
gi 518245522 593 FFTLPIEL 600
Cdd:PRK11107 513 WFHLPLDL 520
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-598 |
4.47e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 68.60 E-value: 4.47e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 493 LTQVIDNIISNALKYSPDGGNIRFGCIVQGGLLKAMISDDGMGIPQENVERIFDRFYRvdrarARSMG-GSGLGLAIARE 571
Cdd:cd16943 4 LNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFT-----TKPVGeGTGLGLSLSYR 78
|
90 100
....*....|....*....|....*..
gi 518245522 572 MIEAHGGAIWAESEEGYGTTIFFTLPI 598
Cdd:cd16943 79 IIQKHGGTIRVASVPGGGTRFTIILPI 105
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
207-251 |
7.88e-14 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 65.93 E-value: 7.88e-14
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 518245522 207 TRPISDMRRQAQAMAKGNFSRKVRVYGNDEIGQLAIAFNHLTNRL 251
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
268-598 |
2.25e-13 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 71.65 E-value: 2.25e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 268 VLSNMTDGVIATDRKGRIMLINETALRLLKVPRELVMHRPISVVLGidseYTFEDLIHMKDSIN---------LDFSSPE 338
Cdd:PRK11073 12 ILNSLINSILLLDDDLAIHYANPAAQQLLAQSSRKLFGTPLPELLS----YFSLNIELMRESLQagqgftdneVTLVIDG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 339 RNYILRVNFSVIQKETGFVngiisvlhdntEQEKIDMERR---------------EFVANVSHELRTPLTTMRsyleala 403
Cdd:PRK11073 88 RSHILSLTAQRLPEGMILL-----------EMAPMDNQRRlsqeqlqhaqqvaarDLVRGLAHEIKNPLGGLR------- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 404 dGAWQDRELA---PSFLNVTQT---ETERMIRLVNDLLQLSKMDSRSSDLNKELVEfnkffnRIIDRFEMSRSQDVHFLR 477
Cdd:PRK11073 150 -GAAQLLSKAlpdPALTEYTKViieQADRLRNLVDRLLGPQRPGTHVTESIHKVAE------RVVQLVSLELPDNVRLIR 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 478 ----LLPEaqyfVEIDTDKLTQVIDNIISNALK-YSPDGGNIR------FGCIVQGGLLKAM----ISDDGMGIPQEnve 542
Cdd:PRK11073 223 dydpSLPE----LAHDPDQIEQVLLNIVRNALQaLGPEGGTITlrtrtaFQLTLHGERYRLAaridIEDNGPGIPPH--- 295
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 518245522 543 rIFDR-FYRVDRARArsmGGSGLGLAIAREMIEAHGGAIWAESEEGYGT-TIFftLPI 598
Cdd:PRK11073 296 -LQDTlFYPMVSGRE---GGTGLGLSIARNLIDQHSGKIEFTSWPGHTEfSVY--LPI 347
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
15-253 |
4.15e-13 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 71.98 E-value: 4.15e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 15 VLVYILLIVIAMQIIGLYFARELEDTLKDSFIESIQQRVDLLEFSMRAEIIKKRGEEDPTIEQSLRTVLYSVRSEDINEI 94
Cdd:COG0840 18 ALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLALLLLLLALLA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 95 RVVDTNFRILATSDTNKQSIVGQRSMDTNVRRSISSEtpfNTIKVDLQKKDRIWVLASPIIYQGEVLGAIYLESNIETVF 174
Cdd:COG0840 98 LALAALALLAALAALLALLELLLAALLAALAIALLAL---AALLALAALALALLALALLAAAAAAAAALAALLEAAALAL 174
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 518245522 175 EQMSEINLILAGGTAMSLAITVILGILIAQTITRPISDMRRQAQAMAKGNFSRKVRVYGNDEIGQLAIAFNHLTNRLQE 253
Cdd:COG0840 175 AAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENLRE 253
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
479-587 |
4.04e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 63.81 E-value: 4.04e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 479 LPEAQYFVeIDTDKLTQVIDNIISNALKYSpdGGNIRFGCIVQGGLLKAMISDDGMGIPQENVERIFDRFYRVDRARArs 558
Cdd:cd16954 25 ISPELRFP-GERNDLMELLGNLLDNACKWC--LEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDEQRP-- 99
|
90 100 110
....*....|....*....|....*....|
gi 518245522 559 mgGSGLGLAIAREMIEAHGGAIWAE-SEEG 587
Cdd:cd16954 100 --GQGLGLAIAKEIVEQYGGELSLSdSPLG 127
|
|
| HAMP |
pfam00672 |
HAMP domain; |
201-253 |
4.10e-12 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 61.10 E-value: 4.10e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 518245522 201 LIAQTITRPISDMRRQAQAMAKGNFSRKVRVYGNDEIGQLAIAFNHLTNRLQE 253
Cdd:pfam00672 1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
378-580 |
1.15e-11 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 67.35 E-value: 1.15e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 378 REFVANVSHELRTPLTTMRSYLEALADGAWQDRELA-PsflnVTQTETERMIRLVNDLLQLSKMDSRSSDLNKEL----- 451
Cdd:PRK10815 267 RTTLTDLTHSLKTPLAVLQSTLRSLRSGKQMSVEQAeP----IMLEQISRISQQIGYYLHRASMRSEHNLLSRELhsvap 342
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 452 ------VEFNKFFNRIIDRFEMSRSQDVHFLrllPEAQYFVEidtdkltqVIDNIISNALKYSpdggnIRFGCI---VQG 522
Cdd:PRK10815 343 lldnltSALNKVYQRKGVNITLDISPEITFV---GEKNDFME--------VMGNVLDNACKYC-----LEFVEIsarQTD 406
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 518245522 523 GLLKAMISDDGMGIPQENVERIFDRFYRVDRARArsmgGSGLGLAIAREMIEAHGGAI 580
Cdd:PRK10815 407 EHLHIVVEDDGPGIPESKRELIFDRGQRADTLRP----GQGLGLSVAREITEQYEGKI 460
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-596 |
1.62e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 60.93 E-value: 1.62e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 493 LTQVIDNIISNALK--YSPDGGNIRFGCIVQGGLLKAMISDDGMGIPQENVERIFDRFYrvdraRARSMG-GSGLGLAIA 569
Cdd:cd16976 1 IQQVLMNLLQNALDamGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFF-----TTKPVGkGTGLGLSIS 75
|
90 100
....*....|....*....|....*..
gi 518245522 570 REMIEAHGGAIWAESEEGYGTTIFFTL 596
Cdd:cd16976 76 YGIVEEHGGRLSVANEEGAGARFTFDL 102
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
205-256 |
3.40e-11 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 58.41 E-value: 3.40e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 518245522 205 TITRPISDMRRQAQAMAKGNFSRKVRVYGNDEIGQLAIAFNHLTNRLQEAQS 256
Cdd:smart00304 2 RLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-593 |
5.81e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 59.72 E-value: 5.81e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 493 LTQVIDNIISNALKYSPD-GGNIRFGCIVQGGL----------LKAMISDDGMGIPQENVERIFDRFYRvdrARArsmGG 561
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGsGGEIILRTRTQRQVtlghprhrlaLRVSVIDNGPGIPPDLQDTIFYPMVS---GRE---NG 74
|
90 100 110
....*....|....*....|....*....|..
gi 518245522 562 SGLGLAIAREMIEAHGGAIWAESEEGYgtTIF 593
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGVIECDSQPGH--TVF 104
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-597 |
3.09e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 57.30 E-value: 3.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 493 LTQVIDNIISNALKYSPD----GGNIRFGCIVQGGLLKAMISDDGMGIPQENVERIFDRFYRvdrarARSMGGSGLGLAI 568
Cdd:cd16915 1 LITIVGNLIDNALDALAAtgapNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVS-----TKGQGERGIGLAL 75
|
90 100
....*....|....*....|....*....
gi 518245522 569 AREMIEAHGGAIWAESEEGYGTTIFFTLP 597
Cdd:cd16915 76 VRQSVERLGGSITVESEPGGGTTFSIRIP 104
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
493-597 |
3.32e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 57.77 E-value: 3.32e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 493 LTQVIDNIISNALKYSPDGGNIRFGC---------------IVQGGLLKAMISDDGMGIPQENVERIFDRFYRVdraraR 557
Cdd:cd16919 1 LELAILNLAVNARDAMPEGGRLTIETsnqrvdadyalnyrdLIPGNYVCLEVSDTGSGMPAEVLRRAFEPFFTT-----K 75
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 518245522 558 SMG-GSGLGLAIAREMIEAHGGAIWAESEEGYGTTIFFTLP 597
Cdd:cd16919 76 EVGkGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
28-253 |
2.34e-09 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 60.03 E-value: 2.34e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 28 IIGLYFARELEDTLKDSFIESIQQRVDLLEFSMRAEIIKKRGEEDPTIEQSLRTVLYSVRSEDINEIRVVDTNFRILATS 107
Cdd:COG2972 3 KSLSLLSIVLLLLILLLLVLLILLLSLLLIILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 108 DTNKQSIVGQRSMDTNVRRSISSETPFNTIKVDLQKKDRIWVLASPIIYQGEVLGAIYLESNIETVFEQMSEINLILAGG 187
Cdd:COG2972 83 LLLLLLLLLLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLRRLILLI 162
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518245522 188 TAMSLAITVILGILIAQTITRPISDMRRQAQAMAKGNFSRkVRVYGNDEIGQLAIAFNHLTNRLQE 253
Cdd:COG2972 163 ILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLVR-LEVSGNDEIGILARSFNEMVERIKE 227
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
262-379 |
4.43e-09 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 59.01 E-value: 4.43e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 262 RRKLASVLSNMTDGVIATDRKGRIMLINETALRLLKVPRELVMHRPISVVLgidSEYTFEDLIHMKDSINLDFSSPERNY 341
Cdd:COG3829 10 EEELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVTELI---PNSPLLEVLKTGKPVTGVIQKTGGKG 86
|
90 100 110
....*....|....*....|....*....|....*...
gi 518245522 342 ILRVNFSVIQKETGFVNGIISVLHDNTEQEKIDMERRE 379
Cdd:COG3829 87 KTVIVTAIPIFEDGEVIGAVETFRDITELKRLERKLRE 124
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
489-597 |
4.97e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 54.08 E-value: 4.97e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 489 DTDKLTQVIDNIISNA---LKYSPDG-GNIRFGCIV-QGGLLKAMISDDGMGIPQENVERIFDRfYRVDRARarsmgGSG 563
Cdd:cd16944 1 DTTQISQVLTNILKNAaeaIEGRPSDvGEVRIRVEAdQDGRIVLIVCDNGKGFPREMRHRATEP-YVTTRPK-----GTG 74
|
90 100 110
....*....|....*....|....*....|....
gi 518245522 564 LGLAIAREMIEAHGGAIWAESEEGYGTTIFFTLP 597
Cdd:cd16944 75 LGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
1-453 |
1.17e-08 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 58.20 E-value: 1.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 1 MQKVSFFKSIHVKFVLVYILLIVIAMQIIGLYFARELEDTLKDSFIESIQQRVDLLEFSMRAEIIKKRGEEDPTIEQSLR 80
Cdd:COG2770 31 ISLRLLLALLLLLLLLLALLLLLLLLLLLLLAALVLLALLLAAALLLLLLLLSLVALAALLLALLLLLLLALLLLLAALL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 81 TVLYSVRSEDINEIRVVDTNFRILATSDTNKQSIVGQRSMDTNVRRSISSETPFNTIKVDLQKKDRIWVLASPIIYQGEV 160
Cdd:COG2770 111 LLLLLAALALLLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAALALALGAGELLLLADLAAAIAALLAAL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 161 LGAIYLESNIETVFEQMSEINLILAGGTAMSLAITVILGILIAQTITRPISDMRRQAQAMAKGNFSRKVRVYGNDEIGQL 240
Cdd:COG2770 191 LLLLLGGLLLVVLLEAALAALLLLLLLALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKDEIGEL 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 241 AIAFNHLTNRLQEAQSTTEGERRKLASVLSNMTDGVIATDRKGRIMLINETALRLLKVPRELVMHRPISVVLGIDSEYTF 320
Cdd:COG2770 271 ARAFNRMADSLRESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADL 350
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 321 EDLIHMKDSINLDFSSPERNYILRVNFSVIQKETGFVNGIISVLHDNTEQEKIDMERREFVANVSHELRTPLTTMRSYLE 400
Cdd:COG2770 351 LLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAAAAAA 430
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 518245522 401 ALADGAWQDRELAPSFLNVTQTETERMIRLVNDLLQLSKMDSRSSDLNKELVE 453
Cdd:COG2770 431 AEAAAAALELAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAA 483
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
79-389 |
1.28e-08 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 57.59 E-value: 1.28e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 79 LRTVLYSVRSEDINEIRVVDTNFRILATSDTNKQSIVGQRSMDTNVRRSISSETPFNTIKVDLQKKDRIWVLASPIIYQG 158
Cdd:COG3850 15 LLALLALLLLALLLLSLLALLLLLERTLLRLLSLLASAGLLAALLAALLLLLSLGLLALLLALLLLLLLLLLAALLSLLL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 159 EVLGAIYLESNIETVFEQMSEINLILAGGTAMSLAITVILGILIAQTITRPISDMRRQAQAMAKGNFSRKVRVYGNDEIG 238
Cdd:COG3850 95 LLLLLLLLLLLLLLLLLAAAINRKLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRDELG 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 239 QLAIAFNHLTNRLQEAQSTTEGERRKLASVLSNMTDGVIATDRKGRIMLINETALRLLKVPRELVMHRPISVVLGIDSEY 318
Cdd:COG3850 175 TLARAFNRMADELQELYAELEEEEELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELL 254
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 518245522 319 TFEDLIHMKDSINLDFSSPERNYILRVNFSVIQKETGFVNGIISVLHDNTEQEKIDMERREFVANVSHELR 389
Cdd:COG3850 255 ALNILAGLLELLLALLLLLLASALLLLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQAIAN 325
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
376-599 |
7.75e-08 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 53.85 E-value: 7.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 376 ERREFVANVSHELRTPLTTMRSYLEALADGAWQDRELApsflnvtqtetERMIRLVNDLLQLSKMDsrssdlnkelVEFN 455
Cdd:COG4585 89 AAREELEEIRELAREALAELRRLVRGLRPPALDDLGLA-----------AALEELAERLLRAAGIR----------VELD 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 456 kffnRIIDRFEMSRSQDVHFLRLLPEAqyfveidtdkltqvidniISNALKYSPdGGNIRFGCIVQGGLLKAMISDDGMG 535
Cdd:COG4585 148 ----VDGDPDRLPPEVELALYRIVQEA------------------LTNALKHAG-ATRVTVTLEVDDGELTLTVRDDGVG 204
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 518245522 536 IPQENVerifdrfyrvdrararsmGGSGLGLAIAREMIEAHGGAIWAESEEGYGTTIFFTLPIE 599
Cdd:COG4585 205 FDPEAA------------------PGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPLA 250
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
384-598 |
1.50e-07 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 54.29 E-value: 1.50e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 384 VSHELRTPLTTMRSYLEALADGAWQDRELAP----SFLNVtQTETERMIRLVNDLLQLS---KMDSRSSDLNKELVEFNK 456
Cdd:PRK13557 170 IAHDFNNLLQVMSGYLDVIQAALSHPDADRGrmarSVENI-RAAAERAATLTQQLLAFArkqRLEGRVLNLNGLVSGMGE 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 457 FFNRIIdrfemsrSQDVHFLRLLPEAQYFVEIDTDKLTQVIDNIISNALKYSPDGGNIR---------------FGCIVQ 521
Cdd:PRK13557 249 LAERTL-------GDAVTIETDLAPDLWNCRIDPTQAEVALLNVLINARDAMPEGGRVTirtrnveiededlamYHGLPP 321
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 518245522 522 GGLLKAMISDDGMGIPQENVERIFDRFYRV-DRARarsmgGSGLGLAIAREMIEAHGGAIWAESEEGYGTTIFFTLPI 598
Cdd:PRK13557 322 GRYVSIAVTDTGSGMPPEILARVMDPFFTTkEEGK-----GTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFPA 394
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
263-366 |
1.56e-07 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 50.11 E-value: 1.56e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 263 RKLASVLSNMTDGVIATDRKGRIMLINETALRLLKVPRELVMHRPISVVLGIDSEYTFEDLI-----HMKDSINLDFS-- 335
Cdd:pfam00989 1 EDLRAILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIPEEDDAEVAELLrqallQGEESRGFEVSfr 80
|
90 100 110
....*....|....*....|....*....|..
gi 518245522 336 -SPERNYILRVNFSVIQKETGFVNGIISVLHD 366
Cdd:pfam00989 81 vPDGRPRHVEVRASPVRDAGGEILGFLGVLRD 112
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
253-379 |
3.01e-07 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 51.95 E-value: 3.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 253 EAQSTTEGERRKLASVLSNMTDGVIATDRKGRIMLINETALRLLKVPRELVMHRPISVVLGIDSEYTFEDLIHMKDSINL 332
Cdd:COG2202 1 TAEEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLPPEDDDEFLELLRAALAGGG 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 518245522 333 DFSSPERN-------YILRVNFSVIQKETGFVNGIISVLHDNTEQEKIDMERRE 379
Cdd:COG2202 81 VWRGELRNrrkdgslFWVELSISPVRDEDGEITGFVGIARDITERKRAEEALRE 134
|
|
| TyrR |
COG3283 |
Transcriptional regulator TyrR of aromatic amino acids metabolism [Transcription, Amino acid ... |
258-313 |
6.82e-07 |
|
Transcriptional regulator TyrR of aromatic amino acids metabolism [Transcription, Amino acid transport and metabolism];
Pssm-ID: 442513 [Multi-domain] Cd Length: 514 Bit Score: 52.11 E-value: 6.82e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 518245522 258 TEGERRKLASVLSNMTDGVIATDRKGRIMLINETALRLLKVPRELVMHRPISVVLG 313
Cdd:COG3283 75 SEREHLELDALLEALPDPVFSIDLKGKIELANPAALSLLGLSEEELIGQPLSELLK 130
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
501-597 |
9.04e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 47.16 E-value: 9.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 501 ISNALKYSPdGGNIRFGCIVQGGLLKAMISDDGMGIPQENVErifdrfyrvdrararsmGGSGLGLAIAREMIEAHGGAI 580
Cdd:cd16917 9 LTNALKHAG-ASRVRVTLSYTADELTLTVVDDGVGFDGPAPP-----------------GGGGFGLLGMRERAELLGGTL 70
|
90
....*....|....*..
gi 518245522 581 WAESEEGYGTTIFFTLP 597
Cdd:cd16917 71 TIGSRPGGGTRVTARLP 87
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
384-580 |
1.86e-06 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 50.84 E-value: 1.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 384 VSHELRTPLTTMRSYL-EALADGAWQDRELAPSFLNVTQTETERMIRLVNDLLQLSkmdsRSSDLNKELVEFNKFFNRII 462
Cdd:COG4192 440 LAHELNQPLNAMSMYLfSAKKALEQENYAQLPTSLDKIEGLIERMDKIIKSLRQFS----RKSDTPLQPVDLRQVIEQAW 515
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 463 DRFEMSRSQDVHFLRLLPEAQYFVeiDTDKLTQVIDNIISNALKYSPDGGNIRFGCIVQGGLLKAMISDDGMGIPQenVE 542
Cdd:COG4192 516 ELVESRAKPQQITLHIPDDLMVQG--DQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGWPL--VD 591
|
170 180 190
....*....|....*....|....*....|....*...
gi 518245522 543 RIFDRFYRVDRArarsmgGSGLGLAIAREMIEAHGGAI 580
Cdd:COG4192 592 KLFTPFTTTKEV------GLGLGLSICRSIMQQFGGDL 623
|
|
| HATPase_PDK-like |
cd16929 |
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ... |
529-597 |
7.57e-06 |
|
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.
Pssm-ID: 340406 [Multi-domain] Cd Length: 169 Bit Score: 46.56 E-value: 7.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 529 ISDDGMGIPQENVERIF------------DRFYRVDRARARS-MGGSGLGLAIAREMIEAHGGAIWAESEEGYGTTIFFT 595
Cdd:cd16929 88 ISDRGGGIPREDLARLFsymystapqpslDDFSDLISGTQPSpLAGFGYGLPMSRLYAEYFGGDLDLQSMEGYGTDVYIY 167
|
..
gi 518245522 596 LP 597
Cdd:cd16929 168 LK 169
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
263-324 |
1.01e-05 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 43.54 E-value: 1.01e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518245522 263 RKLASVLSNMTDGVIATDRKGRIMLINETALRLLKVPRELVMHRPISVVLGIDSEYTFEDLI 324
Cdd:smart00091 1 ERLRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHPEDRERVQEAL 62
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
529-600 |
9.59e-05 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 45.17 E-value: 9.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 529 ISDDGMGIpqeNVERIfdrfyrvdRARARSMG----------------------------------GSGLGLAIAREMIE 574
Cdd:COG0643 326 VSDDGRGL---DLEKI--------RAKAIEKGlitaeeaaalsdeellelifapgfstaeevtdlsGRGVGMDVVKTNIE 394
|
90 100
....*....|....*....|....*.
gi 518245522 575 AHGGAIWAESEEGYGTTIFFTLPIEL 600
Cdd:COG0643 395 ALGGTIEIESEPGKGTTFTLRLPLTL 420
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
272-366 |
1.10e-04 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 41.85 E-value: 1.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 272 MTDGVIATDRKGRIMLINETALRLLKVPRELVMHRPIS-VVLGIDSEYTFEDLIHMKD-----SINLDFSSPERNYI-LR 344
Cdd:cd00130 1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLdLIHPEDREELRERLENLLSggepvTLEVRLRRKDGSVIwVL 80
|
90 100
....*....|....*....|..
gi 518245522 345 VNFSVIQKETGFVNGIISVLHD 366
Cdd:cd00130 81 VSLTPIRDEGGEVIGLLGVVRD 102
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
468-598 |
3.15e-04 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 41.05 E-value: 3.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 468 SRSQDVHFLR-----LLPEAQyFVEIDTDKLTQVIDNIISNALKYS---PDGGNIRFGCIVQGGLLKAMISDDGMGIPQE 539
Cdd:COG2172 6 ADLEDLGLARravraLLRELG-LDEDDADDLVLAVSEAVTNAVRHAyggDPDGPVEVELELDPDGLEIEVRDEGPGFDPE 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 518245522 540 NVERIFDrfyrvdrararSMGGSGLGLAIAREMIEahggAIWAESEEGyGTTIFFTLPI 598
Cdd:COG2172 85 DLPDPYS-----------TLAEGGRGLFLIRRLMD----EVEYESDPG-GTTVRLVKRL 127
|
|
| HATPase_EL346-LOV-HK-like |
cd16951 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
485-597 |
1.21e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.
Pssm-ID: 340427 [Multi-domain] Cd Length: 131 Bit Score: 39.32 E-value: 1.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 485 FVEIDTDKLTQ---VIDNIISNALKYS---PDGGNIRFGCIVQGGLLKAMISDDGMGIPQEnverifdrfyrvdrarARS 558
Cdd:cd16951 29 TGPVSSEVATAiglVVNELLQNALKHAfsdREGGTITIRSVVDGDYLRITVIDDGVGLPQD----------------EDW 92
|
90 100 110
....*....|....*....|....*....|....*....
gi 518245522 559 MGGSGLGLAIAREMIEAHGGAIWAESEEGYGTTIFFTLP 597
Cdd:cd16951 93 PNKGSLGLQIVRSLVEGELKAFLEVQSAENGTRVNIDIP 131
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
512-597 |
1.78e-03 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 39.49 E-value: 1.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 512 GNIRFGCIVQGGLLKAMISDDGMGIpqeNVERIfdrfyrvdRARARSMG------------------------------- 560
Cdd:cd16916 70 GTITLRAEHQGNQVVIEVSDDGRGI---DREKI--------REKAIERGlitadeaatlsddevlnlifapgfstaeqvt 138
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 518245522 561 ---GSGLGLAIAREMIEAHGGAIWAESEEGYGTTIFFTLP 597
Cdd:cd16916 139 dvsGRGVGMDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
501-599 |
2.24e-03 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 41.04 E-value: 2.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 501 ISNALKY---SPDGGNIRFGCIVQGGLLKAMISDDGMGIPQEnverifdrfyrVDRARarsmgGSGLGLAIAREMIEAHG 577
Cdd:COG3920 408 VTNALKHaflSGEGGRIRVSWRREDGRLRLTVSDNGVGLPED-----------VDPPA-----RKGLGLRLIRALVRQLG 471
|
90 100
....*....|....*....|..
gi 518245522 578 GAIwaESEEGYGTTIFFTLPIE 599
Cdd:COG3920 472 GTL--ELDRPEGTRVRITFPLA 491
|
|
| PAS_9 |
pfam13426 |
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ... |
282-369 |
2.42e-03 |
|
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463873 [Multi-domain] Cd Length: 93 Bit Score: 37.44 E-value: 2.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518245522 282 KGRIMLINETALRLLKVPRELVMHRPIS-VVLGIDSEYTFEDLIHMKDS---INLDFSSPERNYI-LRVNFSVIQKETGF 356
Cdd:pfam13426 1 DGRIIYVNDAALRLLGYTREELLGKSITdLFAEPEDSERLREALREGKAvreFEVVLYRKDGEPFpVLVSLAPIRDDGGE 80
|
90
....*....|...
gi 518245522 357 VNGIISVLHDNTE 369
Cdd:pfam13426 81 LVGIIAILRDITE 93
|
|
| PRK11388 |
PRK11388 |
DNA-binding transcriptional regulator DhaR; Provisional |
268-312 |
6.37e-03 |
|
DNA-binding transcriptional regulator DhaR; Provisional
Pssm-ID: 183114 [Multi-domain] Cd Length: 638 Bit Score: 39.66 E-value: 6.37e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 518245522 268 VLSNMTDGVIATDRKGRIMLINETALRLLKVPRELVMHRPISVVL 312
Cdd:PRK11388 208 LLESMDDGVIAWDEQGNLQFLNAQAARLLRLDATASQGRAITELL 252
|
|
| |
