|
Name |
Accession |
Description |
Interval |
E-value |
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
6-598 |
0e+00 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 886.79 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 6 FFRSIQLKFIIIYILLLLVAIQVIGSFFTNELEAELRENFFTSINDRVQLLSYNLEQAFNRErmeDGEGPTLQEEVQSII 85
Cdd:NF033092 1 FFRSIHFKIVLIYVLLILIAMQIIGVYFVRQLETQLLNNFKESINLRANLLSYNLEQELSKE---DEDDETLEEDIRTIL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 86 SDV---DITSLEVINNQSRIIATNDYSSQGDIGKKTTRDMVQQALVTDSVQSGEMFDQATRQQVFVLAQPILDSDGVAVG 162
Cdd:NF033092 78 NDFnnnDISEIQVIDAKGTILGTSDPSNQSIVGQKTTDSDVKRALLGGKDNEKILIDPEDNNRVYVLATPIKSSNGEVVG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 163 VIYLKASMEGVNEQLQNINEIFLKGSILAVTVSAFIGILVARTITKPIIEMRRQAQTMARGDFTQKVNVYGRDEIGHLAE 242
Cdd:NF033092 158 AIYIEASMESVYDQMNNINLIFATGTLIALVITAVLGILLARTITRPIKEMRKQALAMAKGDFSRKVKVYGNDEIGQLAE 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 243 TFNDLNSRLKHSYATIEEERRKLSSVLSNMSDGVIATDNVGAVTLMNEAAGRLIGHNPDEIIGENLLDIFQLEEKIVDIT 322
Cdd:NF033092 238 AFNNLTKRLQEAQATTESERRKLDSVLSHMTDGVIATDRRGRVILINDPALEMLNVSRETVLGQSILDVLGLEEEYTLRD 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 323 ELHDSGSIIIDLSTEEQESLVRANFSTVLDDEDELTGFITVISDVTEQEKIEQERRDFVSNVSHELRTPLTTMRSYIEAL 402
Cdd:NF033092 318 LLEEQDSLLLDFSTEEEPLILRANFSVIQRESGFINGLIAVLHDVTEQEKIEQERREFVANVSHELRTPLTTMRSYLEAL 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 403 TDGAWEDKEIAPKFLGVAQNETERMIRMVNDLLQLSKMDAKEHPLKKERTEFINYFHGIIDRFEMNV-PEHISLKRELPK 481
Cdd:NF033092 398 ADGAWKDPELAPRFLGVTQNETERMIRLVNDLLQLSRMDSKDYKLNKEWVNFNEFFNYIIDRFEMILkNKNITFKREFPK 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 482 GKFNVWLDQDKMTQVLDNIISNAIKYSPEGGKITLRVENRRHHILVSIQDEGMGIAYDKLEKIFERFYRADKARTRKLGG 561
Cdd:NF033092 478 RDLWVEIDTDKITQVLDNIISNAIKYSPEGGTITFRLLETHNRIIISISDQGLGIPKKDLDKIFDRFYRVDKARSRKMGG 557
|
570 580 590
....*....|....*....|....*....|....*..
gi 518205580 562 TGLGLAIAKELVEAHHGKIWAKSKEGKGTAILFTLPL 598
Cdd:NF033092 558 TGLGLAIAKEVVEAHGGRIWAESEEGKGTTIYFTLPY 594
|
|
| HK_VicK |
NF033093 |
cell wall metabolism sensor histidine kinase VicK; This model describes the protein VicK (or ... |
207-597 |
8.58e-108 |
|
cell wall metabolism sensor histidine kinase VicK; This model describes the protein VicK (or WalK) as found in Streptococcus pneumoniae, This protein is shorter than the WalK of Staphylococcus aureus, although apparently is functionally similar. Compare to model NF033092 (HK_WalK). VicK is a sensor histidine kinase involved in regulating cell wall metabolism. Its two component system partner is the response regulatory VicR.
Pssm-ID: 467965 [Multi-domain] Cd Length: 448 Bit Score: 331.69 E-value: 8.58e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 207 TKPIIEMRRQAQTMARGDFTQKVNVYGRDEIGHLAETFNDLNSRLKHSYATIEEERRKLSSVLSNMSDGVIATDNVGAVT 286
Cdd:NF033093 38 NKQLRQLNQKVKDLIAGDYSEVLDMQGDPELTELTNSLNDLSEVFRLTHENLEQEKNRLASILSYMTDGVLATNRRGQII 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 287 LMNEAAGRLIGHNPDEIIGENLLDIFQLEekivDITELHD----SGSIIIDLSTEEQESL-VRANFSTVLDDEDELTGFI 361
Cdd:NF033093 118 MINDTAQKQLNVKREEALNMNILDLLDID----DEYDLRDlitkTPELTLDSRDENGEFLsLRVRFALIRRESGFISGLV 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 362 TVISDVTEQEKIEQERRDFVSNVSHELRTPLTTMRSYIEALTDGAWeDKEIAPKFLGVAQNETERMIRMVNDLLQLSKMD 441
Cdd:NF033093 194 AVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGAL-SEPVAPSFIKVSLDETNRMMRMISDLLSLSRID 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 442 AKEHPLKKERTEFINYFHGIIDRF------EMNVPEHISLKRELPKGKFNVWLDQDKMTQVLDNIISNAIKYSPEGGKIT 515
Cdd:NF033093 273 NQTSHLDVELTNFTAFITFILNRFdqiksqDTETGKKYEIVRDYPITSIWVEIDTDKMTQVIDNILNNAIKYSPDGGKIT 352
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 516 LRVENRRHHILVSIQDEGMGIAYDKLEKIFERFYRADKARTRKLGGTGLGLAIAKELVEAHHGKIWAKSKEGKGTAILFT 595
Cdd:NF033093 353 VSMKTTDTQLIISISDEGLGIPKKDLPLIFDRFYRVDKARSRAQGGTGLGLAIAKEIIKQHKGFIWAKSEYGKGSTFTIV 432
|
..
gi 518205580 596 LP 597
Cdd:NF033093 433 LP 434
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
210-601 |
1.14e-105 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 324.20 E-value: 1.14e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 210 IIEMRRQAQTMARGDFTQKVNVYGRDEIGHLAETFNDLNSRLKHSYATIEEERRKLSSVLSNMSDGVIATDNVGAVTLMN 289
Cdd:COG5002 3 LLLLLLLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 290 EAAGRLIGHNPDEIIGENLLDIFQLEEKIVDITELHDSGSIIIDLSTEEQESLVRanfstVLDDEDELTGFITVISDVTE 369
Cdd:COG5002 83 LLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLR-----LSALLLGLLLLAAVERDITE 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 370 QEKIEQERRDFVSNVSHELRTPLTTMRSYIEALTDGAWEDKEIAPKFLGVAQNETERMIRMVNDLLQLSKMDAKEHPLKK 449
Cdd:COG5002 158 LERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEK 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 450 ERTEFINYFHGIIDRFEMNVPEH-ISLKRELPKGKFNVWLDQDKMTQVLDNIISNAIKYSPEGGKITLRVENRRHHILVS 528
Cdd:COG5002 238 EPVDLAELLEEVVEELRPLAEEKgIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRIS 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 518205580 529 IQDEGMGIAYDKLEKIFERFYRADKARTRKLGGTGLGLAIAKELVEAHHGKIWAKSKEGKGTAILFTLPLMNQ 601
Cdd:COG5002 318 VRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLARE 390
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
183-598 |
5.38e-89 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 282.24 E-value: 5.38e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 183 IFLKGSILAVTVSAFIGILVARTITKPIIEMRRQAQTMARGDFTQKVNVYGRDEIGHLAETFNDLNSRLKHSYATIEEER 262
Cdd:COG5000 10 LLLLIALLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKEQREELEERR 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 263 RKLSSVLSNMSDGVIATDNVGAVTLMNEAAGRLIGHNPDEIIGENLLDIF---QLEEKIVDITELHDSGSIIIDLSTEEQ 339
Cdd:COG5000 90 RYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGKPLEELLpelDLAELLREALERGWQEEIELTRDGRRT 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 340 ESLVRANFstvlddedELTGFITVISDVTEQekIEQER----RDFVSNVSHELRTPLTTMRSYIE----ALTDGAWEDKE 411
Cdd:COG5000 170 LLVRASPL--------RDDGYVIVFDDITEL--LRAERlaawGELARRIAHEIKNPLTPIQLSAErlrrKLADKLEEDRE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 412 IAPKFLGVAQNETERMIRMVNDLLQLSKMDakehPLKKERTEFINYFHGIIDRFEM-NVPEHISLKRELPKGKFNVWLDQ 490
Cdd:COG5000 240 DLERALDTIIRQVDRLKRIVDEFLDFARLP----EPQLEPVDLNELLREVLALYEPaLKEKDIRLELDLDPDLPEVLADR 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 491 DKMTQVLDNIISNAIKYSPEGGKITLRVENRRHHILVSIQDEGMGIAYDKLEKIFERFYradkarTRKLGGTGLGLAIAK 570
Cdd:COG5000 316 DQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFF------TTKPKGTGLGLAIVK 389
|
410 420
....*....|....*....|....*...
gi 518205580 571 ELVEAHHGKIWAKSKEGKGTAILFTLPL 598
Cdd:COG5000 390 KIVEEHGGTIELESRPGGGTTFTIRLPL 417
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
369-598 |
7.95e-79 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 249.05 E-value: 7.95e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 369 EQEKIEQERRDFVSNVSHELRTPLTTMRSYIEALTDGAWEDKEIAPKFLGVAQNETERMIRMVNDLLQLSKMDAKEHPLK 448
Cdd:COG2205 8 ELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLESGKLSLE 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 449 KERTEFINYFHGIIDRFEMNVPEH-ISLKRELPKGKFNVWLDQDKMTQVLDNIISNAIKYSPEGGKITLRVENRRHHILV 527
Cdd:COG2205 88 LEPVDLAELLEEAVEELRPLAEEKgIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREGDGVRI 167
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 518205580 528 SIQDEGMGIAYDKLEKIFERFYRADkaRTRKLGGTGLGLAIAKELVEAHHGKIWAKSKEGKGTAILFTLPL 598
Cdd:COG2205 168 SVSDNGPGIPEEELERIFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPL 236
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
269-598 |
6.12e-71 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 231.72 E-value: 6.12e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 269 LSNMSDGVIATDNVGAVTLMNEAAGRLIGHNPDEIIGENLLDIFQLEEKIVDITELHDSGSIIIDLSTEEQESLVRANFS 348
Cdd:COG0642 1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 349 TVLDDEDELTGFITVISDVTEQ-EKIEQERRDFVSNVSHELRTPLTTMRSYIEALTDGAWEDKEiapKFLGVAQNETERM 427
Cdd:COG0642 81 LLLLLLLLLLLLLLLLLALLLLlEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQR---EYLETILRSADRL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 428 IRMVNDLLQLSKMDAKEHPLKKERTEFINYFHGIIDRFEMNVPE-HISLKRELPKGKFNVWLDQDKMTQVLDNIISNAIK 506
Cdd:COG0642 158 LRLINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEkGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIK 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 507 YSPEGGKITLRVENRRHHILVSIQDEGMGIAYDKLEKIFERFYRADKARTRklGGTGLGLAIAKELVEAHHGKIWAKSKE 586
Cdd:COG0642 238 YTPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRG--GGTGLGLAIVKRIVELHGGTIEVESEP 315
|
330
....*....|..
gi 518205580 587 GKGTAILFTLPL 598
Cdd:COG0642 316 GKGTTFTVTLPL 327
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
258-590 |
5.15e-70 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 229.40 E-value: 5.15e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 258 IEEERRKLSSVLSNMSDGVIATDNVGAVTLMNEAAGRLIGHNPDEIIGENLLDIFQLEEKIVDITELHDSGSIIIDLSTE 337
Cdd:TIGR02966 1 LSALLSRFRAAAQALPDAVVVLDEEGQIEWCNPAAERLLGLRWPDDLGQRITNLIRHPEFVEYLAAGRFSEPLELPSPIN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 338 EQESLvraNFSTVLDDEDEltgFITVISDVTEQEKIEQERRDFVSNVSHELRTPLTTMRSYIEALTDGAWEDKEIAPKFL 417
Cdd:TIGR02966 81 SERVL---EIRIAPYGEEQ---KLLVARDVTRLRRLEQMRRDFVANVSHELRTPLTVLRGYLETLADGPDEDPEEWNRAL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 418 GVAQNETERMIRMVNDLLQLSKMDAKEHPLKKERTefinyfhgiidrfemNVPEHIS-LKRE---LPKGKF--------- 484
Cdd:TIGR02966 155 EIMLEQSQRMQSLVEDLLTLSRLESAASPLEDEPV---------------DMPALLDhLRDEaeaLSQGKNhqitfeidg 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 485 NVWL--DQDKMTQVLDNIISNAIKYSPEGGKITLRVENRRHHILVSIQDEGMGIAYDKLEKIFERFYRADKARTRKLGGT 562
Cdd:TIGR02966 220 GVDVlgDEDELRSAFSNLVSNAIKYTPEGGTITVRWRRDGGGAEFSVTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGT 299
|
330 340
....*....|....*....|....*...
gi 518205580 563 GLGLAIAKELVEAHHGKIWAKSKEGKGT 590
Cdd:TIGR02966 300 GLGLAIVKHVLSRHHARLEIESELGKGS 327
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
257-603 |
6.88e-60 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 203.54 E-value: 6.88e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 257 TIEEERRKLSSVLSNMSDGVIATDNVGAVTLMNEAAGRLIGHNPDEIIGENLLDIFQLEEKIVD-ITELHDSGSII---- 331
Cdd:COG3852 1 ALRESEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFPEDSPLRElLERALAEGQPVtere 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 332 IDLSTEEQESLVRANFSTVLDDEDELTGFITVISDVTEQEKIEQERR---------DFVSNVSHELRTPLTTMRSYIEAL 402
Cdd:COG3852 81 VTLRRKDGEERPVDVSVSPLRDAEGEGGVLLVLRDITERKRLERELRraeklaavgELAAGLAHEIRNPLTGIRGAAQLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 403 TDGAWEDKEiaPKFLGVAQNETERMIRMVNDLLQLSKMdakehplKKERTEFINyFHGIIDR----FEMNVPEHISLKRE 478
Cdd:COG3852 161 ERELPDDEL--REYTQLIIEEADRLNNLVDRLLSFSRP-------RPPEREPVN-LHEVLERvlelLRAEAPKNIRIVRD 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 479 LPKGKFNVWLDQDKMTQVLDNIISNAIKYSPEGGKITLRVENR----------RHHILVSIQDEGMGIAYDKLEKIFERF 548
Cdd:COG3852 231 YDPSLPEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVErqvtlgglrpRLYVRIEVIDNGPGIPEEILDRIFEPF 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 518205580 549 YradkarTRKLGGTGLGLAIAKELVEAHHGKIWAKSKEGKGTAILFTLPLMNQKR 603
Cdd:COG3852 311 F------TTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQAEE 359
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
142-598 |
6.87e-57 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 202.12 E-value: 6.87e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 142 TRQ-QVFVLAQP---ILDS------DGVAVGVIYLKASMEGVNEQLQNINEIFLKGSILAVTVSAFIGILVARTITKPII 211
Cdd:PRK11360 140 TNTpLVESGGQVrggILNSmipierNGEVIGYIWANELTEDIRRQAWKMDRRIYAVLAAGLVIGLLLIFLLSRRFSANVD 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 212 EMRRQAQTMARgDFTQKVNVYgRDEIGHLAETFNDLNSRLKhsyatieeERRKLSSV-LSNMSDGVIATDNVGAVTLMNE 290
Cdd:PRK11360 220 IIKDGLSTLEN-DLSTRLPPL-PGELGEISQAINNLAQALR--------ETRSLNELiLESIADGVIAIDRQGKITTMNP 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 291 AAGRLIGHNPDEIIGENLLDIFQLEEKIVDIteLHDS---GSIIIDLS----TEEQESLVRANFSTVLDDEDELTGFITV 363
Cdd:PRK11360 290 AAEVITGLQRHELVGKPYSELFPPNTPFASP--LLDTlehGTEHVDLEisfpGRDRTIELSVSTSLLHNTHGEMIGALVI 367
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 364 ISDVTEQEKIE-----QERR----DFVSNVSHELRTPLTTMRSYIEALTDGAweDKEIAPKFLGVAQNETERMIRMVNDL 434
Cdd:PRK11360 368 FSDLTERKRLQrrvarQERLaalgELVAGVAHEIRNPLTAIRGYVQIWRQQT--SDPPSQEYLSVVLREVDRLNKVIDQL 445
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 435 LQLSKmDAKEHPLKKERTEFI----NYFHGIIDRFEMNVpeHISLKRELPKgkfnVWLDQDKMTQVLDNIISNAIKYSPE 510
Cdd:PRK11360 446 LEFSR-PRESQWQPVSLNALVeevlQLFQTAGVQARVDF--ETELDNELPP----IWADPELLKQVLLNILINAVQAISA 518
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 511 GGKITLRVEN-RRHHILVSIQDEGMGIAYDKLEKIFERFYradkarTRKLGGTGLGLAIAKELVEAHHGKIWAKSKEGKG 589
Cdd:PRK11360 519 RGKIRIRTWQySDGQVAVSIEDNGCGIDPELLKKIFDPFF------TTKAKGTGLGLALSQRIINAHGGDIEVESEPGVG 592
|
....*....
gi 518205580 590 TAILFTLPL 598
Cdd:PRK11360 593 TTFTLYLPI 601
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
363-597 |
1.40e-48 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 175.20 E-value: 1.40e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 363 VISDVTEQEKIEQERRDFVSNVSHELRTPLTTMRSYIEALTDGAWEDKeIAPKFLGVAQNETERMIRMVNDLLQLSKMDA 442
Cdd:PRK11006 190 VARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQDQPLEGA-LREKALHTMREQTQRMEGLVKQLLTLSKIEA 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 443 KEHPLKKERtefinyfhgiidrfeMNVP--------EHISLKRELPKGKFN------VWLDQDKMTQVLDNIISNAIKYS 508
Cdd:PRK11006 269 APTIDLNEK---------------VDVPmmlrvlerEAQTLSQGKHTITFEvdnslkVFGNEDQLRSAISNLVYNAVNHT 333
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 509 PEGGKITLRVENRRHHILVSIQDEGMGIAYDKLEKIFERFYRADKARTRKLGGTGLGLAIAKELVEAHHGKIWAKSKEGK 588
Cdd:PRK11006 334 PEGTHITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGK 413
|
....*....
gi 518205580 589 GTAILFTLP 597
Cdd:PRK11006 414 GTRFSFVLP 422
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
249-604 |
1.66e-48 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 176.32 E-value: 1.66e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 249 SRLKHSYATIEEERRKLSSVLSNMSDGVIATDNVGAVTLMNEAAGRLIGHNPDEIIGENLLDIFQLEEK---IVDITELH 325
Cdd:COG5809 127 TERKRMEEALRESEEKFRLIFNHSPDGIIVTDLDGRIIYANPAACKLLGISIEELIGKSILELIHSDDQenvAAFISQLL 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 326 DSGSI----IIDLSTEEQESLVRANFSTvLDDEDELTGFITVISDVTEQEKIEQERRD---------FVSNVSHELRTPL 392
Cdd:COG5809 207 KDGGIaqgeVRFWTKDGRWRLLEASGAP-IKKNGEVDGIVIIFRDITERKKLEELLRKseklsvvgeLAAGIAHEIRNPL 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 393 TTMRSYIEALTDGAWEDKEiapKFLGVAQNETERMIRMVNDLLQLSKMDAKE------HPLKKERTEFIN---YFHGIid 463
Cdd:COG5809 286 TSLKGFIQLLKDTIDEEQK---TYLDIMLSELDRIESIISEFLVLAKPQAIKyepkdlNTLIEEVIPLLQpqaLLKNV-- 360
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 464 RFEMNVPEHISLkrelpkgkfnVWLDQDKMTQVLDNIISNAIKYSPEGGKITLRV-ENRRHHILVSIQDEGMGIAYDKLE 542
Cdd:COG5809 361 QIELELEDDIPD----------ILGDENQLKQVFINLLKNAIEAMPEGGNITIETkAEDDDKVVISVTDEGCGIPEERLK 430
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518205580 543 KIFERFYradkarTRKLGGTGLGLAIAKELVEAHHGKIWAKSKEGKGTAILFTLPLMNQKRR 604
Cdd:COG5809 431 KLGEPFY------TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIKLSEQV 486
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
371-604 |
2.77e-44 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 164.04 E-value: 2.77e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 371 EKIEQERRDFVSNVSHELRTPLTTMRSYIEALTDGAwedKEIAPKFLGVAQNETERMIRMVNDLLQLSKMDAKEHPLKKE 450
Cdd:PRK10549 234 EKNEQMRRDFMADISHELRTPLAVLRGELEAIQDGV---RKFTPESVASLQAEVGTLTKLVDDLHQLSLSDEGALAYRKT 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 451 RTEFINYFHGII----DRFEmnvPEHISLKRELPKgKFNVWLDQDKMTQVLDNIISNAIKYSPEGGKITLRVENRRHHIL 526
Cdd:PRK10549 311 PVDLVPLLEVAGgafrERFA---SRGLTLQLSLPD-SATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLR 386
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 518205580 527 VSIQDEGMGIAYDKLEKIFERFYRADKARTRKLGGTGLGLAIAKELVEAHHGKIWAKSKEGKGTAILFTLPLMNQKRR 604
Cdd:PRK10549 387 LTFADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERDLQR 464
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
120-597 |
4.43e-43 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 161.49 E-value: 4.43e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 120 RDMVQQALVTDSVQSGEMFDQATRQQVFVLAQPILDSDGVAVGVIYLKASMEGVNEQLQNINEIFLKGSILAVTVSAFIG 199
Cdd:COG4251 6 LLLLLLLLLLLLLLLLLLLLLVLLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 200 ILVARTITKPIIEMRRQAQTMARGDFTQKVNVYGRDEIGHLAETFNDLNSRLKHSYATIEEERRKLSSVLSNMSDGVIAT 279
Cdd:COG4251 86 LLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 280 DNVGAVTLMNEAAGRLIGHNPDEIIGENLLDIFQLEEKIVDITELHDSGSIIIDLSTEEQESLVRANFSTVLDDEDELTG 359
Cdd:COG4251 166 LILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 360 FITVISDVTEQEKIE-------------------QERRDFVSNVSHELRTPLTTMRSYIEAL-TDGAWEDKEIAPKFLGV 419
Cdd:COG4251 246 LLLILVLELLELRLEleeleeeleertaelersnEELEQFAYVASHDLREPLRKISGFSQLLeEDYGDKLDEEGREYLER 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 420 AQNETERMIRMVNDLLQLSKMDAKEhpLKKERTEFINYFHGIIDRFEMNVPE-HISLK-RELPKgkfnVWLDQDKMTQVL 497
Cdd:COG4251 326 IRDAAERMQALIDDLLAYSRVGRQE--LEFEPVDLNELLEEVLEDLEPRIEErGAEIEvGPLPT----VRGDPTLLRQVF 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 498 DNIISNAIKYSPEG--GKITLRVENRRHHILVSIQDEGMGIAYDKLEKIFERFYRADkaRTRKLGGTGLGLAIAKELVEA 575
Cdd:COG4251 400 QNLISNAIKYSRPGepPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLH--SRDEYEGTGIGLAIVKKIVER 477
|
490 500
....*....|....*....|..
gi 518205580 576 HHGKIWAKSKEGKGTAILFTLP 597
Cdd:COG4251 478 HGGRIWVESEPGEGATFYFTLP 499
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
249-598 |
5.35e-43 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 161.05 E-value: 5.35e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 249 SRLKHSYATIEEERRKLSSVLSNMSDGVIATDNVGAVTLMNEAAGRLIGHNPDEIIGENLLDIFQLEEK------IVDIT 322
Cdd:COG5805 143 TKKKKIEEILQEQEERLQTLIENSPDLICVIDTDGRILFINESIERLFGAPREELIGKNLLELLHPCDKeefkerIESIT 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 323 ELHDSGSIIIDLSTEEQES-LVRANFSTVLDDEDELTGFITVISDVTEQEKIEQERRDF---------VSNVSHELRTPL 392
Cdd:COG5805 223 EVWQEFIIEREIITKDGRIrYFEAVIVPLIDTDGSVKGILVILRDITEKKEAEELMARSeklsiagqlAAGIAHEIRNPL 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 393 TTMRSYIEALTDGAwEDKEiapKFLGVAQNETERMIRMVNDLLQLSKMDAkehpLKKERTEFINYFHGIIDRFEM----- 467
Cdd:COG5805 303 TSIKGFLQLLQPGI-EDKE---EYFDIMLSELDRIESIISEFLALAKPQA----VNKEKENINELIQDVVTLLETeailh 374
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 468 NVPEHISLKRELPkgkfNVWLDQDKMTQVLDNIISNAIKYSPEGGKITLRVENRRHHILVSIQDEGMGIAYDKLEKIFER 547
Cdd:COG5805 375 NIQIRLELLDEDP----FIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEP 450
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 518205580 548 FYradkarTRKLGGTGLGLAIAKELVEAHHGKIWAKSKEGKGTAILFTLPL 598
Cdd:COG5805 451 FF------TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPL 495
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
342-597 |
6.05e-40 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 151.90 E-value: 6.05e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 342 LVRANFST--VLDDEDELTGFITVISDVTEQ-EKIEQERRDFVSNVSHELRTPLTTMRSYIEALTDGAwedKEIAPKFLG 418
Cdd:NF012163 202 LAAGDYTTrvTPTSNDELGKLAQDFNQLASTlEKNEQMRRDFMADISHELRTPLAVLRAELEAIQDGI---RKFTPESLD 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 419 VAQNETERMIRMVNDLLQLSKMDAKEHPLKKERTEFINYF----HGIIDRFEmnvPEHISLKRELPkGKFNVWLDQDKMT 494
Cdd:NF012163 279 SLQAEVGTLTKLVDDLHDLSMSDEGALAYQKASVDLVPLLevegGAFRERFA---SAGLELEVSLP-DSSLVFGDRDRLM 354
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 495 QVLDNIISNAIKYSPEGGKITLRVENRRHHILVSIQDEGMGIAYDKLEKIFERFYRADKARTRKLGGTGLGLAIAKELVE 574
Cdd:NF012163 355 QLFNNLLENSLRYTDSGGSLHISASQRPKEVTLTVADSAPGVSDEQLARLFERFYRVEVSRNRASGGSGLGLAISLNIVQ 434
|
250 260
....*....|....*....|...
gi 518205580 575 AHHGKIWAKSKEGKGTAILFTLP 597
Cdd:NF012163 435 AHGGTLHAAHSPLGGLRIVVTLP 457
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
489-598 |
5.51e-39 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 138.94 E-value: 5.51e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 489 DQDKMTQVLDNIISNAIKYSPEGGKITLRVENRRHHILVSIQDEGMGIAYDKLEKIFERFYRADKaRTRKLGGTGLGLAI 568
Cdd:smart00387 2 DPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLSI 80
|
90 100 110
....*....|....*....|....*....|
gi 518205580 569 AKELVEAHHGKIWAKSKEGKGTAILFTLPL 598
Cdd:smart00387 81 VKKLVELHGGEISVESEPGGGTTFTITLPL 110
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
493-596 |
5.91e-39 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 138.50 E-value: 5.91e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 493 MTQVLDNIISNAIKYSPEGGKITLRVENRRHHILVSIQDEGMGIAYDKLEKIFERFYRADKARTRklGGTGLGLAIAKEL 572
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREG--GGTGLGLAIVRRI 78
|
90 100
....*....|....*....|....
gi 518205580 573 VEAHHGKIWAKSKEGKGTAILFTL 596
Cdd:cd00075 79 VEAHGGRITVESEPGGGTTFTVTL 102
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
258-598 |
1.49e-38 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 145.71 E-value: 1.49e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 258 IEEERRKLSSVLSNMSDGVIATDNVGAVTLMNEAAGRLIGHNPDEIIGENLLDIFQLEEKIVDITELHDSGSIIIDLSTE 337
Cdd:COG4191 7 LLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 338 EQESLVRANFSTVLDDEDELTGFITVISDVTEQEKIEQERRD----------------FVSNVSHELRTPLTTMRSYIEA 401
Cdd:COG4191 87 LLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRElqeqlvqseklaalgeLAAGIAHEINNPLAAILGNAEL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 402 LTD--GAWEDKEIAPKFLGVAQNETERMIRMVNDLLQLSKMDakehPLKKERTEFINYFHGIIDRFEMNVPEH-ISLKRE 478
Cdd:COG4191 167 LRRrlEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRD----EEEREPVDLNELIDEALELLRPRLKARgIEVELD 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 479 LPKGKFNVWLDQDKMTQVLDNIISNAIKYSPEG--GKITLRVENRRHHILVSIQDEGMGIAYDKLEKIFERFYRadkarT 556
Cdd:COG4191 243 LPPDLPPVLGDPGQLEQVLLNLLINAIDAMEEGegGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFT-----T 317
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 518205580 557 RKLG-GTGLGLAIAKELVEAHHGKIWAKSKEGKGTAILFTLPL 598
Cdd:COG4191 318 KPVGkGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPL 360
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
379-593 |
7.70e-37 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 142.91 E-value: 7.70e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 379 DFVSNVSHELRTPLTTMRSYIE-ALT---DGAwEDKEIapkfLGVAQNETERMIRMVNDLLQLSKMDAKEHPLKKERTEF 454
Cdd:TIGR01386 243 QFSADLAHELRTPLTNLLGQTQvALSqprTGE-EYREV----LESNLEELERLSRMVSDMLFLARADNGQLALERVRLDL 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 455 INYFHGIIDRFEMNVPEH-ISLKRElpkGKFNVWLDQDKMTQVLDNIISNAIKYSPEGGKITLRVENRRHHILVSIQDEG 533
Cdd:TIGR01386 318 AAELAKVAEYFEPLAEERgVRIRVE---GEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPG 394
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 534 MGIAYDKLEKIFERFYRADKARTRKLGGTGLGLAIAKELVEAHHGKIWAKSKEGKGTAIL 593
Cdd:TIGR01386 395 PGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDGKTRFIL 454
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
76-597 |
6.98e-36 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 141.32 E-value: 6.98e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 76 TLQEEVQSIISDVDITSLEVI---NNQSRIIATNDYSSQGDIGK--KTTRDMVQQALVTDSVQSGEMFDQA-TRQQVFVL 149
Cdd:NF040691 77 TLLSVLASASGAMQGAFDVVLlvpGDDPSGLGPRASGSVGLVSQipEELREAVAGGQVAQQYQSVALPSGDgSSAPALVV 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 150 AQPiLDSDGVAVGVIYLKASMEGVNEQLQNINEIFLKGSILAVTVSAFIGILVARTITKPIIEMRRQAQTMARGDFTQKV 229
Cdd:NF040691 157 GTP-VTLPVAGNYELYLLFPLEDEQSTLALVRGTLLLGGLALVVLLGLIAWLVTRQVVAPVRSAARTAERFAAGDLSERM 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 230 NVYGRDEIGHLAETFNDLNSRLKHSyatieeerrklssvlsnmsdgviatdnvgavtlmneaagrlighnpdeiigenll 309
Cdd:NF040691 236 PVKGEDDLARLARSFNQMADSLQRQ------------------------------------------------------- 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 310 dIFQLEEkivditelhdsgsiiidlsteeqeslvranFSTVlddedeltgfitvisdvteqekieQERrdFVSNVSHELR 389
Cdd:NF040691 261 -IRQLEE------------------------------LSRL------------------------QQR--FVSDVSHELR 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 390 TPLTTMRSYIEALTDGAWEDKEIAPKFLGVAQNETERMIRMVNDLLQLSKMDAKEHPLKKERTEFINYFHGIIDRFEmNV 469
Cdd:NF040691 284 TPLTTIRMAADVIHDSRDDFDPATARSAELLHTELDRFESLLSDLLEISRFDAGAAELDVEPVDLRPLVRRVVDALR-QL 362
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 470 PEH--ISLKRELPKGKFNVWLDQDKMTQVLDNIISNAIKYSpEGGKITLRVENRRHHILVSIQDEGMGIAYDKLEKIFER 547
Cdd:NF040691 363 AERagVELRVDAPGTPVVAEVDPRRVERVLRNLVVNAIEHG-EGKPVVVTVAQDDTAVAVTVRDHGVGLKPGEVALVFDR 441
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|
gi 518205580 548 FYRADKARTRKLGGTGLGLAIAKELVEAHHGKIWAKSKEGKGTAILFTLP 597
Cdd:NF040691 442 FWRADPARARTTGGTGLGLAIALEDARLHGGWLEAWGRPGQGSQFRLTLP 491
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
370-597 |
2.89e-35 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 137.00 E-value: 2.89e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 370 QEKIE-QERRDF----VSNVSHELRTPLTTMRSYIEALTDGAW-EDKEIAP----KFLGVAQNETERMIRMVNDLLQLSK 439
Cdd:PRK09303 139 QENETlLEQLKFkdrvLAMLAHDLRTPLTAASLALETLELGQIdEDTELKPalieQLQDQARRQLEEIERLITDLLEVGR 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 440 MDAKEHPLKKERTEFINYFHGIIDRFEMNVPE-HISLKRELPKGKFNVWLDQDKMTQVLDNIISNAIKYSPEGGKITLRV 518
Cdd:PRK09303 219 TRWEALRFNPQKLDLGSLCQEVILELEKRWLAkSLEIQTDIPSDLPSVYADQERIRQVLLNLLDNAIKYTPEGGTITLSM 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 519 ENR-RHHILVSIQDEGMGIAYDKLEKIFERFYRADkaRTRKLGGTGLGLAIAKELVEAHHGKIWAKSKEGKGTAILFTLP 597
Cdd:PRK09303 299 LHRtTQKVQVSICDTGPGIPEEEQERIFEDRVRLP--RDEGTEGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTLP 376
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
495-598 |
6.36e-35 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 127.61 E-value: 6.36e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 495 QVLDNIISNAIKYSPEGGkITLRV-----ENRRHHILVSIQDEGMGIAYDKLEKIFERFYRADKARTRKLGGTGLGLAIA 569
Cdd:cd16922 3 QILLNLLGNAIKFTEEGE-VTLRVsleeeEEDGVQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAIS 81
|
90 100
....*....|....*....|....*....
gi 518205580 570 KELVEAHHGKIWAKSKEGKGTAILFTLPL 598
Cdd:cd16922 82 KKLVELMGGDISVESEPGQGSTFTFTLPL 110
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
375-598 |
6.46e-35 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 137.76 E-value: 6.46e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 375 QERrdFVSNVSHELRTPLTTMRSYIEALTDGAWEDKEiapkfLGVAQNETERMIRMVNDLLQLSKMDAKEHpLKKERTEF 454
Cdd:PRK09470 243 QQR--LLSDISHELRTPLTRLQLATALLRRRQGESKE-----LERIETEAQRLDSMINDLLVLSRNQQKNH-LERETFKA 314
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 455 INYFHGIID--RFEMnvpEH--ISLKRELPKGKFNVWLDQDKMTQVLDNIISNAIKYSPEGGKITLRVENRRHHILVsiQ 530
Cdd:PRK09470 315 NSLWSEVLEdaKFEA---EQmgKSLTVSAPPGPWPINGNPNALASALENIVRNALRYSHTKIEVAFSVDKDGLTITV--D 389
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 518205580 531 DEGMGIAYDKLEKIFERFYRADKARTRKLGGTGLGLAIAKELVEAHHGKIWA-KSKEGkGTAILFTLPL 598
Cdd:PRK09470 390 DDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAeDSPLG-GLRLTIWLPL 457
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
489-598 |
1.68e-33 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 123.63 E-value: 1.68e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 489 DQDKMTQVLDNIISNAIKYSPEGGKITLRVEnRRHHILVSIQDEGMGIAYDKLEKIFERFYRADKartRKLGGTGLGLAI 568
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAGEITVTLS-EGGELTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGLSI 77
|
90 100 110
....*....|....*....|....*....|
gi 518205580 569 AKELVEAHHGKIWAKSKEGKGTAILFTLPL 598
Cdd:pfam02518 78 VRKLVELLGGTITVESEPGGGTTVTLTLPL 107
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
371-597 |
3.07e-32 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 130.28 E-value: 3.07e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 371 EKIEQ---ERRDFVSNVSHELRTPLTTMRSYIEALTDGAWEDKEIApKFLGVAQNETERMIRMVNDLLQLSKMDAKEHPL 447
Cdd:PRK09835 253 ERIEDvftRQSNFSADIAHEIRTPITNLITQTEIALSQSRSQKELE-DVLYSNLEELTRMAKMVSDMLFLAQADNNQLIP 331
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 448 KKERTEFINYFHGIIDRFEMNVPE-HISLKrelpkgkFN-----VWLDQDKMTQVLDNIISNAIKYSPEGGKITLRVENR 521
Cdd:PRK09835 332 EKKMLDLADEVGKVFDFFEAWAEErGVELR-------FVgdpcqVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEV 404
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518205580 522 RHHILVSIQDEGMGIAYDKLEKIFERFYRADKARTRKLGGTGLGLAIAKELVEAHHGKIWAKSkEGKGTAILFTLP 597
Cdd:PRK09835 405 DHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTS-DARGTRFVISLP 479
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
495-598 |
3.12e-32 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 119.74 E-value: 3.12e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 495 QVLDNIISNAIKYSPEggKITLRVENRRHHILVSIQDEGMGIAYDKLEKIFERFYRADKARTRKLGGTGLGLAIAKELVE 574
Cdd:cd16949 3 RALENVLRNALRYSPS--KILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERAIE 80
|
90 100
....*....|....*....|....
gi 518205580 575 AHHGKIWAKSKEGKGTAILFTLPL 598
Cdd:cd16949 81 QHGGKIKASNRKPGGLRVRIWLPA 104
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
379-598 |
2.03e-28 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 118.79 E-value: 2.03e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 379 DFVSNVSHELRTPLTTMRSYIEALTDGAweDKEIAPKFLGVAQNETERMIRMVNDLLQLSKMDAKEHPLKKERTEFINYF 458
Cdd:PRK11100 258 QYVQTLTHELKSPLAAIRGAAELLQEDP--PPEDRARFTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALL 335
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 459 HGIIDRFEMN-VPEHISLKRELPKGKfnVWLDQDKMTQVLDNIISNAIKYSPEGGKITLRVENRRHHILVSIQDEGMGIA 537
Cdd:PRK11100 336 EELVEAREAQaAAKGITLRLRPDDAR--VLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIP 413
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 518205580 538 YDKLEKIFERFY---RADKARTrklgGTGLGLAIAKELVEAHHGKIWAKSKEGKGTAILFTLPL 598
Cdd:PRK11100 414 DYALPRIFERFYslpRPANGRK----STGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPR 473
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
489-597 |
2.86e-28 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 109.09 E-value: 2.86e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 489 DQDKMTQVLDNIISNAIKYSPEGGKITLRVENRRHHILVSIQDEGMGIAYDKLEKIFERFYRADKARTRKLGGTGLGLAI 568
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 518205580 569 AKELVEAHHGKIWAKSKEGKGTAILFTLP 597
Cdd:cd16946 81 CHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
369-598 |
3.37e-28 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 120.27 E-value: 3.37e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 369 EQEKIEQERRDFVSNVSHELRTPLTTMRSYIEALTDGAWEDKEiaPKFLGVAQNETERMIRMVNDLLQLSKMDAKEHPLK 448
Cdd:TIGR02956 456 EAEEANRAKSAFLATMSHEIRTPLNGILGTLELLGDTGLTSQQ--QQYLQVINRSGESLLDILNDILDYSKIEAGHLSIS 533
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 449 KERTEFINYFHGIIDRFEMNVPE-HISLKRELPKGKFNVWL-DQDKMTQVLDNIISNAIKYSPEgGKITLRVE-NRRHHI 525
Cdd:TIGR02956 534 PRPFDLNALLDDVHHLMVSRAQLkGIQLRLNIPEQLPNWWQgDGPRIRQVLINLVGNAIKFTDR-GSVVLRVSlNDDSSL 612
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 518205580 526 LVSIQDEGMGIAYDKLEKIFERFYRADKarTRKLGGTGLGLAIAKELVEAHHGKIWAKSKEGKGTAILFTLPL 598
Cdd:TIGR02956 613 LFEVEDTGCGIAEEEQATLFDAFTQADG--RRRSGGTGLGLAISQRLVEAMDGELGVESELGVGSCFWFTLPL 683
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
364-598 |
4.56e-27 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 116.67 E-value: 4.56e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 364 ISDVTEQEKI----EQERRDFVSNVSHELRTPLTTMRSYIEALT-DGAWEDKEIAPKFLGVAQnETERMIRMVNDLLQLS 438
Cdd:PRK10490 647 LTASEEQARLaserEQLRNALLAALSHDLRTPLTVLFGQAEILTlDLASEGSPHARQASEIRQ-QVLNTTRLVNNLLDMA 725
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 439 KMDAKEHPLKKERTEFINYFHGIIDRFEMNVPEHiSLKRELPKGKFNVWLDQDKMTQVLDNIISNAIKYSPEGGKITLRV 518
Cdd:PRK10490 726 RIQSGGFNLRKEWLTLEEVVGSALQMLEPGLSGH-PINLSLPEPLTLIHVDGPLFERVLINLLENAVKYAGAQAEIGIDA 804
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 519 ENRRHHILVSIQDEGMGIAYDKLEKIFERFYRADKARTrkLGGTGLGLAIAKELVEAHHGKIWAKSKEGKGTAILFTLPL 598
Cdd:PRK10490 805 HVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESA--IPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLPL 882
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
384-580 |
1.00e-25 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 108.93 E-value: 1.00e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 384 VSHELRTPLTTMRSYIEALTDGAWEDKEIAPKFLgvaQNETERMIRMVNDLLQLSKMDAKEHPLKKERTEFINYFHGIID 463
Cdd:NF012226 145 IAHELRTPITILQGRLQGILDGVFEPDPALFKSL---LNQVEGLSHLVEDLRTLSLVENQQLRLNYESVDLKDSIEKVLK 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 464 RFEMNVpEHISLKRELPKGKFNVWLDQDKMTQVLDNIISNAIKYSpEGGKITLRVENRRHHILVSIQDEGMGIAYDKLEK 543
Cdd:NF012226 222 MFEDRL-EQAQLTIVLNLTATPVFCDRRRIEQVLIALIDNAIRYA-NAGKLKISSSVIQDDWILQIEDEGPGIAEEYQQD 299
|
170 180 190
....*....|....*....|....*....|....*..
gi 518205580 544 IFERFYRADKARTRKLGGTGLGLAIAKELVEAHHGKI 580
Cdd:NF012226 300 LFNPFFRLEQSRNKEFGGTGLGLAVVHAIVIAHKGSI 336
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
377-598 |
3.25e-25 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 108.54 E-value: 3.25e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 377 RRDFVSNVSHELRTPLTTMRsYIEALTDGAWEDKEIApkflgvaqneTERMI----RMVNDLLQLSKMDAKEHPLKKERT 452
Cdd:PRK10604 212 KKQLIDGIAHELRTPLVRLR-YRLEMSDNLSAAESQA----------LNRDIgqleALIEELLTYARLDRPQNELHLSEP 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 453 EFINYFHGIIDRFEMNVPE-HISLKReLPKGKFNVwLDQDKMTQVLDNIISNAIKYSpeGGKITLRVENRRHHILVSIQD 531
Cdd:PRK10604 281 DLPAWLSTHLADIQAVTPEkTVRLDT-PHQGDYGA-LDMRLMERVLDNLLNNALRYA--HSRVRVSLLLDGNQACLIVED 356
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518205580 532 EGMGIAYDKLEKIFERFYRADKARTRKLGGTGLGLAIAKELVEAHHGKIWAKSKEGKGTAILFTLPL 598
Cdd:PRK10604 357 DGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWPV 423
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
489-598 |
3.57e-25 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 100.26 E-value: 3.57e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 489 DQDKMTQVLDNIISNAIKYSPEGGKITLRVE-NRRHHILVSIQDEGMGIAYDKLEKIFERFYRADKARTRKLGGTGLGLA 567
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEkFRLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80
|
90 100 110
....*....|....*....|....*....|.
gi 518205580 568 IAKELVEAHHGKIWAKSKEGKGTaiLFTLPL 598
Cdd:cd16925 81 IVKEFVELHGGTVTVSDAPGGGA--LFQVEL 109
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
499-597 |
9.41e-25 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 98.81 E-value: 9.41e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 499 NIISNAIKYSPEGGKITLRVENRRHHILVSIQDEGMGIAYDKLEKIFERFYRADKARTRKLGGTGLGLAIAKELVEAHHG 578
Cdd:cd16952 7 NLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVMSRHDA 86
|
90
....*....|....*....
gi 518205580 579 KIWAKSKEGKGTAILFTLP 597
Cdd:cd16952 87 RLLIASELGKGSRFTCLFP 105
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
486-593 |
1.31e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 98.63 E-value: 1.31e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 486 VWLDQDKMTQVLDNIISNAIKYSPEGGKITLRVENRRHHiLVSIQDEGMGIAYDKLEKIFERFYRADKartRKLGGTGLG 565
Cdd:cd16940 7 VQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGA-VIRVEDNGPGIDEEELEALFERFYRSDG---QNYGGSGLG 82
|
90 100
....*....|....*....|....*...
gi 518205580 566 LAIAKELVEAHHGKIWAKSKEGKGTAIL 593
Cdd:cd16940 83 LSIVKRIVELHGGQIFLGNAQGGGLEAW 110
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
384-603 |
1.60e-24 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 106.79 E-value: 1.60e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 384 VSHELRTPLTTMR---SYIEALTDGAWEDKEIAPkflgVAQNETERMIRMVNDLLQLSK-----------MDAKEHPLKK 449
Cdd:PRK10364 244 VAHEIRNPLSSIKglaKYFAERAPAGGEAHQLAQ----VMAKEADRLNRVVSELLELVKpthlalqavdlNDLINHSLQL 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 450 ERTEFINyfHGIIDRFEMNvpehislkRELPKgkfnVWLDQDKMTQVLDNIISNAIKYSPEGGKITLRVENRRHHILVSI 529
Cdd:PRK10364 320 VSQDANS--REIQLRFTAN--------DTLPE----IQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISV 385
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 518205580 530 QDEGMGIAYDKLEKIFERFYradkarTRKLGGTGLGLAIAKELVEAHHGKIWAKSKEGKGTAILFTLPLMNQKR 603
Cdd:PRK10364 386 TDSGKGIAADQLEAIFTPYF------TTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVNITRR 453
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
240-598 |
2.58e-22 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 99.15 E-value: 2.58e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 240 LAETFNDLNSRLKHSYATIEEERRKLSSVLSNMSDGVIATDNVGAVTLMNEAAGRLIGhnpDEIIGENLLDIFQLEEKIV 319
Cdd:COG3290 61 LLLLLLLLAALLLKLLEEIARLVEEREAVLESIREGVIAVDRDGRITLINDAARRLLG---LDAIGRPIDEVLAEVLETG 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 320 DITELHDSGSIIIDLSTeeqeslvranfsTVLDDEDELTGFITVISDVTEQEKIEQERRDFVSNV------SHELRTPLT 393
Cdd:COG3290 138 ERDEEILLNGRVLVVNR------------VPIRDDGRVVGAVATFRDRTELERLEEELEGVKELAealraqRHDFRNHLH 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 394 TMRSYIEAltdGAWED-KEIAPKFLGVAQNETERMIRMVND-----LLqLSKM-DAKEHplkkertefinyfhGIidRFE 466
Cdd:COG3290 206 TISGLLQL---GEYDEaLEYIDEISEELQELIDSLLSRIGNpvlaaLL-LGKAaRARER--------------GI--DLT 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 467 MNVPEHISlkrelpkgkfNVWLDQDKMTQVLDNIISNAI----KYSPEGGKITLRVENRRHHILVSIQDEGMGIAYDKLE 542
Cdd:COG3290 266 IDIDSDLP----------DLPLSDTDLVTILGNLLDNAIeaveKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLE 335
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 518205580 543 KIFERFYRadkarTRKLGGTGLGLAIAKELVEAHHGKIWAKSKEGKGTAILFTLPL 598
Cdd:COG3290 336 KIFERGFS-----TKLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPK 386
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
384-598 |
3.63e-22 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 99.17 E-value: 3.63e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 384 VSHELRTPLTTMRSYIEALTdgawEDKEIAPK---FLGVAQNETERMIRMVNDLLQLskmdAKEHPLKKERTEF---INY 457
Cdd:COG5806 208 IAHEVRNPLTVVRGFIQLLQ----EPELSDEKrkqYIRIALEELDRAEAIITDYLTF----AKPQPEKLEKIDVseeLEH 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 458 FHGIIDRF-EMNvpeHISLKRELPkGKFNVWLDQDKMTQVLDNIISNAIKYSPEGGKITLRVENRRHHILVSIQDEGMGI 536
Cdd:COG5806 280 VIDVLSPYaNMN---NVEIQTELE-PGLYIEGDRQKLQQCLINIIKNGIEAMPNGGTLTIDVSIDKNKVIISIKDTGVGM 355
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518205580 537 AYDKLEKIFERFYradkarTRKLGGTGLGLAIAKELVEAHHGKIWAKSKEGKGTAILFTLPL 598
Cdd:COG5806 356 TKEQLERLGEPYF------STKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITLPL 411
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
495-598 |
3.72e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 88.63 E-value: 3.72e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 495 QVLDNIISNAIKYSPEGGKITLRVENRRHHILVSIQDEGMGIAYDKLEKIFERFYradkaRTRKLG-GTGLGLAIAKELV 573
Cdd:cd16943 6 QVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFF-----TTKPVGeGTGLGLSLSYRII 80
|
90 100
....*....|....*....|....*
gi 518205580 574 EAHHGKIWAKSKEGKGTAILFTLPL 598
Cdd:cd16943 81 QKHGGTIRVASVPGGGTRFTIILPI 105
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
489-597 |
8.87e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 87.73 E-value: 8.87e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 489 DQDKMTQVLDNIISNAIKYSPEGGKITLRVENRRHHILVSIQDEGMGIAYDKLEKIFERFYRADKARtRKLGGTGLGLAI 568
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGR-NFQESTGMGLYL 80
|
90 100
....*....|....*....|....*....
gi 518205580 569 AKELVEAHHGKIWAKSKEGKGTAILFTLP 597
Cdd:cd16948 81 VKKLCDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
369-598 |
1.10e-20 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 96.63 E-value: 1.10e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 369 EQEKIEQERRDFVSNVSHELRTPLTTMRSYIEALTDGAWEDKEIapKFLGVAQNETERMIRMVNDLLQLSKMDAKEHPLK 448
Cdd:PRK15347 390 RAEQANKRKSEHLTTISHEIRTPLNGVLGALELLQNTPLTAEQM--DLADTARQCTLSLLAIINNLLDFSRIESGQMTLS 467
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 449 KERTEFINyfhgIIDR--FEMNVPEH---ISLK----RELPKgkfNVWLDQDKMTQVLDNIISNAIKYSPEGGkITLRVE 519
Cdd:PRK15347 468 LEETALLP----LLDQamLTIQGPAQsksLTLRtfvgAHVPL---YLHLDSLRLRQILVNLLGNAVKFTETGG-IRLRVK 539
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 518205580 520 NRRHHILVSIQDEGMGIAYDKLEKIFERFYRADKartrKLGGTGLGLAIAKELVEAHHGKIWAKSKEGKGTAILFTLPL 598
Cdd:PRK15347 540 RHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADT----HSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLPL 614
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-597 |
1.61e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 86.61 E-value: 1.61e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 493 MTQVLDNIISNAIKYSPEG--GKITLRVENRRHHILVSIQDEGMGIAYDKLEKIFERFYRADKarTRKLGGTGLGLAIAK 570
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRrpPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHS--REEYEGTGVGLAIVR 78
|
90 100
....*....|....*....|....*..
gi 518205580 571 ELVEAHHGKIWAKSKEGKGTAILFTLP 597
Cdd:cd16921 79 KIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-597 |
1.66e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 86.67 E-value: 1.66e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 493 MTQVLDNIISNAIKYSPEGGKITLRVENRRHHILVSIQDEGMGIAYDKLEKIFERFYRADKArtRKLGGTGLGLAIAKEL 572
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNS--RNTEGAGLGLSIAKAI 78
|
90 100
....*....|....*....|....*
gi 518205580 573 VEAHHGKIWAKSkEGKGTAILFTLP 597
Cdd:cd16923 79 IELHGGSASAEY-DDNHDLFKVRLP 102
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
366-598 |
3.78e-20 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 95.01 E-value: 3.78e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 366 DVTE----QEKIEQERRD---FVSNVSHELRTPLTTMRSYIEALTDGAWEDKEIapKFLGVAQNETERMIRMVNDLLQLS 438
Cdd:PRK11091 265 DITErkryQDALEKASRDkttFISTISHELRTPLNGIVGLSRILLDTELTAEQR--KYLKTIHVSAITLGNIFNDIIDMD 342
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 439 KMDAKEHPLKKERTEFINYfhgiidrfeMNVPEHISLKRELPKG-KFN----------VWLDQDKMTQVLDNIISNAIKY 507
Cdd:PRK11091 343 KMERRKLQLDNQPIDFTDF---------LADLENLSGLQAEQKGlRFDlepllplphkVITDGTRLRQILWNLISNAVKF 413
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 508 SPEGGkITLRVE-NRRHHILVSIQDEGMGIAYDKLEKIFERFYRA-DKARTRKLGGTGLGLAIAKELVEAHHGKIWAKSK 585
Cdd:PRK11091 414 TQQGG-VTVRVRyEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVkDSHGGKPATGTGIGLAVSKRLAQAMGGDITVTSE 492
|
250
....*....|...
gi 518205580 586 EGKGTAILFTLPL 598
Cdd:PRK11091 493 EGKGSCFTLTIHA 505
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
378-597 |
3.86e-20 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 94.81 E-value: 3.86e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 378 RDFVSNVSHELRTPLTTMRSYIEALTDGAWEDKeiAPKFLGVAQNETERMIRMVNDLLQLSKMDAKEHPLKKERTEFINY 457
Cdd:TIGR03785 486 ENMSSRLSHELRTPVAVVRSSLENLELQALEQE--KQKYLERAREGTERLSMILNNMSEATRLEQAIQSAEVEDFDLSEV 563
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 458 FHGIIDRFEMNVPEHislkrelpkgKFNVWLDQDKMT---------QVLDNIISNAIKYSPEGGKITLRVENRRHHILVS 528
Cdd:TIGR03785 564 LSGCMQGYQMTYPPQ----------RFELNIPETPLVmrgspeliaQMLDKLVDNAREFSPEDGLIEVGLSQNKSHALLT 633
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518205580 529 IQDEGMGIAYDKLEKIFERFY--RADKArtRKLGGTGLGLAIAKELVEAHHGKIWAKSK-EGKGTAILFTLP 597
Cdd:TIGR03785 634 VSNEGPPLPEDMGEQLFDSMVsvRDQGA--QDQPHLGLGLYIVRLIADFHQGRIQAENRqQNDGVVFRISLP 703
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
374-598 |
2.53e-19 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 90.74 E-value: 2.53e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 374 EQERRDFVSNVSHELRTPLTTMRSYIEALTDgawEDKEIAPKFLgvaqNETERMIRMVNDLLQLSKMDakehplKKERTE 453
Cdd:PRK09467 226 EDDRTLLMAGVSHDLRTPLTRIRLATEMMSE---EDGYLAESIN----KDIEECNAIIEQFIDYLRTG------QEMPME 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 454 FINyFHGIIDRF---EMNVPEHISLkrELPKGKFNVWLDQDKMTQVLDNIISNAIKYSPEGGKITLRVENRRhhILVSIQ 530
Cdd:PRK09467 293 MAD-LNALLGEViaaESGYEREIET--ALQPGPIEVPMNPIAIKRALANLVVNAARYGNGWIKVSSGTEGKR--AWFQVE 367
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 518205580 531 DEGMGIAYDKLEKIFERFYRADKARTRKlgGTGLGLAIAKELVEAHHGKIWAKSKEGKGTAILFTLPL 598
Cdd:PRK09467 368 DDGPGIPPEQLKHLFQPFTRGDSARGSS--GTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLPL 433
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
489-596 |
4.06e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 83.33 E-value: 4.06e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 489 DQDKMTQVLDNIISNAIKYSPEGGKITLRVENRRHHILVSIQDEGMGIAYDKLEKIFERFYRADKARTRKLGGTGLGLAI 568
Cdd:cd16947 17 NTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQGNGLGLTI 96
|
90 100
....*....|....*....|....*...
gi 518205580 569 AKELVEAHHGKIWAKSKEGKGTAILFTL 596
Cdd:cd16947 97 TKRLAESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
377-598 |
5.51e-19 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 91.72 E-value: 5.51e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 377 RRDFVSNVSHELRTPLTTMRSYIEALTdGAWEDKEIAPKFLGVAQNETERMIRMVNDLLQLSKMDAKEHPLKKERTEFIN 456
Cdd:PRK09959 712 KSQFLATMSHEIRTPISSIMGFLELLS-GSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWVDIPT 790
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 457 YFHGIIDRF-EMNVPEHISLK--RELPKgKFNVWLDQDKMTQVLDNIISNAIKYSPEGG-KIT---LRVENRRHHILVSI 529
Cdd:PRK09959 791 LVQNTCHSFgAIAASKSIALScsSTFPD-HYLVKIDPQAFKQVLSNLLSNALKFTTEGAvKITtslGHIDDNHAVIKMTI 869
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 518205580 530 QDEGMGIAYDKLEKIFERFYRADKARTRKlgGTGLGLAIAKELVEAHHGKIWAKSKEGKGTAILFTLPL 598
Cdd:PRK09959 870 MDSGSGLSQEEQQQLFKRYSQTSAGRQQT--GSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPV 936
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
495-597 |
8.14e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 82.06 E-value: 8.14e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 495 QVLDNIISNAIK----YSPEGGKITLRVE-NRRHHILVSIQDEGMGIAYDKLEKIFERFYradkarTRKLGGTGLGLAIA 569
Cdd:cd16920 3 QVLINLVRNGIEamseGGCERRELTIRTSpADDRAVTISVKDTGPGIAEEVAGQLFDPFY------TTKSEGLGMGLSIC 76
|
90 100
....*....|....*....|....*...
gi 518205580 570 KELVEAHHGKIWAKSKEGKGTAILFTLP 597
Cdd:cd16920 77 RSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
379-598 |
3.55e-18 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 88.75 E-value: 3.55e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 379 DFVSNVSHELRTPL----------------TTMRSYIealtdgawedkeiapkflgvaqNETER----MIRMVNDLLQLS 438
Cdd:PRK11107 295 EFLANMSHELRTPLngvigftrqtlktpltPTQRDYL----------------------QTIERsannLLAIINDILDFS 352
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 439 KMDA-K---EH---PLKKERTEFINYFHG-----------IIDRfemNVPEHISlkrelpkGkfnvwlDQDKMTQVLDNI 500
Cdd:PRK11107 353 KLEAgKlvlENipfSLRETLDEVVTLLAHsahekgleltlNIDP---DVPDNVI-------G------DPLRLQQIITNL 416
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 501 ISNAIKYSpEGGKITLRVENRRH-----HILVSIQDEGMGIAYDKLEKIFERFYRADKARTRKLGGTGLGLAIAKELVEA 575
Cdd:PRK11107 417 VGNAIKFT-ESGNIDILVELRALsntkvQLEVQIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQKLVNE 495
|
250 260
....*....|....*....|...
gi 518205580 576 HHGKIWAKSKEGKGTAILFTLPL 598
Cdd:PRK11107 496 MGGDISFHSQPNRGSTFWFHLPL 518
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
489-580 |
6.03e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 79.43 E-value: 6.03e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 489 DQDKMTQVLDNIISNAIKYSPEGGKITLRVENRRHHILVSIQDEGMGIAYDKLEKIFERFYRADKARTRKlGGTGLGLAI 568
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSG-GHYGMGLYI 79
|
90
....*....|..
gi 518205580 569 AKELVEAHHGKI 580
Cdd:cd16975 80 AKNLVEKHGGSL 91
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
376-577 |
9.12e-18 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 86.24 E-value: 9.12e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 376 ERRdFVSNVSHELRTPLTTMRSYIE----ALTDGAWEDKEIAPKFLGVaqnetERMIRMVNDLLQLSKMDAKEHPLKKER 451
Cdd:PRK10337 237 ERR-FTSDAAHELRSPLAALKVQTEvaqlSDDDPQARKKALLQLHAGI-----DRATRLVDQLLTLSRLDSLDNLQDVAE 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 452 TEF--------INYFH-----GIIDRFEMNVPEHISLKRELpkgkfnvwldqdKMTQVLDNIISNAIKYSPEGGKITLRV 518
Cdd:PRK10337 311 IPLedllqsavMDIYHtaqqaGIDVRLTLNAHPVIRTGQPL------------LLSLLVRNLLDNAIRYSPQGSVVDVTL 378
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 518205580 519 ENRRHHILvsiqDEGMGIAYDKLEKIFERFYR---ADKArtrklgGTGLGLAIAKELVEAHH 577
Cdd:PRK10337 379 NARNFTVR----DNGPGVTPEALARIGERFYRppgQEAT------GSGLGLSIVRRIAKLHG 430
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-598 |
1.20e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 78.63 E-value: 1.20e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 493 MTQVLDNIISNAIKYSPEGGKITLRVENRRHHILVsiQDEGMGIAYDKLEKIFERFYRADKARTRKLGGTGLGLAIAKEL 572
Cdd:cd16939 1 MARALDNLLRNALRYAHRTVRIALLVSGGRLTLIV--EDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRV 78
|
90 100
....*....|....*....|....*.
gi 518205580 573 VEAHHGKIWAKSKEGKGTAILFTLPL 598
Cdd:cd16939 79 ALWHGGHVECDDSELGGACFRLTWPR 104
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
268-598 |
1.51e-17 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 84.36 E-value: 1.51e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 268 VLSNMSDGVIATDNVGAVTLMNEAAGRLIGHNPDEIIG---ENLLDIFQLEEKIvdITELHDSGSIIidlsTEEQESLVR 344
Cdd:PRK11073 12 ILNSLINSILLLDDDLAIHYANPAAQQLLAQSSRKLFGtplPELLSYFSLNIEL--MRESLQAGQGF----TDNEVTLVI 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 345 ANFSTVLddedELT------GFITV-ISDVTEQEKIEQER---------RDFVSNVSHELRTPLTTMRSYIEALTDgAWE 408
Cdd:PRK11073 86 DGRSHIL----SLTaqrlpeGMILLeMAPMDNQRRLSQEQlqhaqqvaaRDLVRGLAHEIKNPLGGLRGAAQLLSK-ALP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 409 DKEIApKFLGVAQNETERMIRMVNDLLqlskmdAKEHPLKKErTEFInyfHGIIDR----FEMNVPEHISLKRE----LP 480
Cdd:PRK11073 161 DPALT-EYTKVIIEQADRLRNLVDRLL------GPQRPGTHV-TESI---HKVAERvvqlVSLELPDNVRLIRDydpsLP 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 481 kgkfNVWLDQDKMTQVLDNIISNAIK-YSPEGGKITLR--------VENRRHHIL--VSIQDEGMGIA---YDKLekife 546
Cdd:PRK11073 230 ----ELAHDPDQIEQVLLNIVRNALQaLGPEGGTITLRtrtafqltLHGERYRLAarIDIEDNGPGIPphlQDTL----- 300
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 518205580 547 rFYRADKARTrklGGTGLGLAIAKELVEAHHGKIWAKSKEGKgTAILFTLPL 598
Cdd:PRK11073 301 -FYPMVSGRE---GGTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLPI 347
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
369-598 |
1.79e-17 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 86.50 E-value: 1.79e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 369 EQEKIEQERRDFVSNVSHELRTPLTTMRSYIEALTDgawedKEIAPKFLGVAQ---NETERMIRMVNDLLQLSKMDAKEH 445
Cdd:PRK11466 436 EAEKASQAKSAFLAAMSHEIRTPLYGILGTAQLLAD-----NPALNAQRDDLRaitDSGESLLTILNDILDYSAIEAGGK 510
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 446 PLKKERTEF---------INYFHGIIDRFEMNVPEHISlkRELPkgkfnVWLDQD--KMTQVLDNIISNAIKYSpEGGKI 514
Cdd:PRK11466 511 NVSVSDEPFeprpllestLQLMSGRVKGRPIRLATDIA--DDLP-----TALMGDprRIRQVITNLLSNALRFT-DEGSI 582
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 515 TLRVENRRHHILVSIQDEGMGIAYDKLEKIFERFYRADKARtrklGGTGLGLAIAKELVEAHHGKIWAKSKEGKGTAILF 594
Cdd:PRK11466 583 VLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCL 658
|
....
gi 518205580 595 TLPL 598
Cdd:PRK11466 659 RLPL 662
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
376-442 |
3.86e-17 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 75.71 E-value: 3.86e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518205580 376 ERRDFVSNVSHELRTPLTTMRSYIEALTDgaWEDKEIAPKFLGVAQNETERMIRMVNDLLQLSKMDA 442
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRD--EKLDEEQREYLETILRSAERLLRLINDLLDLSRIEA 65
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-597 |
5.53e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 76.72 E-value: 5.53e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 493 MTQVLDNIISNAIKYSpeGGKITLRVENRRHHILVSIQDEGMGIAYDKLEKIFERFYRADKARTrkLGGTGLGLAIAKEL 572
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQRI 76
|
90 100
....*....|....*....|....*
gi 518205580 573 VEAHHGKIWAKSKEGKGTAILFTLP 597
Cdd:cd16950 77 SDAHGGSLTLANRAGGGLCARIELP 101
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
489-593 |
7.57e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 76.35 E-value: 7.57e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 489 DQDKMTQVLDNIISNAIKYSPEGGKITLRVENRRHHILVSIQDEGMGIAYDKLEKIFERFYRADKARTRKlGGTGLGLAI 568
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQ-KSTGLGLAF 79
|
90 100
....*....|....*....|....*
gi 518205580 569 AKELVEAHHGKIWAKSKEGKGTAIL 593
Cdd:cd16945 80 VQEVAQLHGGRITLRNRPDGVLAFL 104
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
374-439 |
1.74e-16 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 73.79 E-value: 1.74e-16
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518205580 374 EQERRDFVSNVSHELRTPLTTMRSYIEALTDGAWEDKEIApKFLGVAQNETERMIRMVNDLLQLSK 439
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQR-EYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-592 |
1.89e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 75.30 E-value: 1.89e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 493 MTQVLDNIISNAIKYSP-EGGKITLRVENRRHHILVSIQDEGMGIAYDKLEKIFERFYrADKARTRKLG-GTGLGLAIAK 570
Cdd:cd16953 1 LGQVLRNLIGNAISFSPpDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFY-TERPANEAFGqHSGLGLSISR 79
|
90 100
....*....|....*....|..
gi 518205580 571 ELVEAHHGKIWAKSKEGKGTAI 592
Cdd:cd16953 80 QIIEAHGGISVAENHNQPGQVI 101
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
370-579 |
2.04e-16 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 81.17 E-value: 2.04e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 370 QEKIEQERRdFVSNVSHELRTPLTTMRSYIEALTDgawedkeiapkfLGVAQNET-----ERMIRMVNDLLQLSK----- 439
Cdd:PRK10755 131 TSTLDQERL-FTADVAHELRTPLAGIRLHLELLEK------------QHHIDVAPliarlDQMMHTVEQLLQLARagqsf 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 440 -------MDAKEHPLKKERTEFInyfhgiidrfEMNVPEHISLKRELPKGKFNVWLDQDKMTQVLDNIISNAIKYSPEGG 512
Cdd:PRK10755 198 ssghyqtVKLLEDVILPSQDELS----------EMLEQRQQTLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGS 267
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518205580 513 KITLRVENRRHHILVSIQDEGMGIAYDKLEKIFERFYRADkartRKLGGTGLGLAIAKELVEAHHGK 579
Cdd:PRK10755 268 TITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRMD----SRYGGIGLGLSIVSRITQLHHGQ 330
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
369-602 |
3.28e-16 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 82.42 E-value: 3.28e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 369 EQEKIEQERR-----------DFVSNVSHELRTPLTTMRSYIEaLTDGAWEDKEIAPKFLGVAQNETERMIRMVNDLLQL 437
Cdd:PRK13837 431 ETERDALERRleharrleavgTLASGIAHNFNNILGAILGYAE-MALNKLARHSRAARYIDEIISAGARARLIIDQILAF 509
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 438 SKmdakEHPLKKERTEFINYFHGIIDRFEMNVPEHISLKRELPKGKFNVWLDQDKMTQVLDNIISNAIKYSPEGGKITL- 516
Cdd:PRK13837 510 GR----KGERNTKPFDLSELVTEIAPLLRVSLPPGVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDIs 585
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 517 --RVENRRH------------HILVSIQDEGMGIAYDKLEKIFERFYradkarTRKLGGTGLGLAIAKELVEAHHGKIWA 582
Cdd:PRK13837 586 lsRAKLRAPkvlshgvlppgrYVLLRVSDTGAGIDEAVLPHIFEPFF------TTRAGGTGLGLATVHGIVSAHAGYIDV 659
|
250 260
....*....|....*....|
gi 518205580 583 KSKEGKGTAILFTLPLMNQK 602
Cdd:PRK13837 660 QSTVGRGTRFDVYLPPSSKV 679
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
376-442 |
9.38e-16 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 71.83 E-value: 9.38e-16
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518205580 376 ERRDFVSNVSHELRTPLTTMRSYIEALTDGAWEDKEiaPKFLGVAQNETERMIRMVNDLLQLSKMDA 442
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQ--REYLETILREAERLLRLINDLLDLSRIEA 65
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
368-602 |
3.83e-15 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 79.25 E-value: 3.83e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 368 TEQEKIEQERRDFVSNVSHELRTPLTTMRSYIEALtdgawEDKEI---APKFLGVAQNETERMIRMVNDLLQLSKMDAKE 444
Cdd:PRK10841 438 QAAEQASQSKSMFLATVSHELRTPLYGIIGNLDLL-----QTKELpkgVDRLVTAMNNSSSLLLKIISDILDFSKIESEQ 512
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 445 hpLKKERTEFI----------NYFHGIIDR-------FEMNVPehislkrelpkgkfnVWLDQDKM--TQVLDNIISNAI 505
Cdd:PRK10841 513 --LKIEPREFSprevinhitaNYLPLVVKKrlglycfIEPDVP---------------VALNGDPMrlQQVISNLLSNAI 575
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 506 KYSPEGGkITLRVENRRHHILVSIQDEGMGIAYDKLEKIFERFYRADKARTRKLGGTGLGLAIAKELVEAHHGKIWAKSK 585
Cdd:PRK10841 576 KFTDTGC-IVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMDGDISVDSE 654
|
250
....*....|....*..
gi 518205580 586 EGKGTAILFTLPLMNQK 602
Cdd:PRK10841 655 PGMGSQFTIRIPLYGAQ 671
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
472-580 |
2.23e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 70.35 E-value: 2.23e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 472 HISLKRELPKGKFNVWlDQDKMTQVLDNIISNAIKYSPEGGKITLRVENrrHHILVSIQDEGMGIAYDKLEKIFERFYRA 551
Cdd:cd16954 18 GVSISLDISPELRFPG-ERNDLMELLGNLLDNACKWCLEFVEVTARQTD--GGLHLIVDDDGPGVPESQRSKIFQRGQRL 94
|
90 100
....*....|....*....|....*....
gi 518205580 552 DKARTrklgGTGLGLAIAKELVEAHHGKI 580
Cdd:cd16954 95 DEQRP----GQGLGLAIAKEIVEQYGGEL 119
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-597 |
1.76e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 67.04 E-value: 1.76e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 493 MTQVLDNIISNAIK-YSPEGGKITLR--------VENRRHHI--LVSIQDEGMGIAYDKLEKIFERFYradkarTRKLGG 561
Cdd:cd16918 1 LIQVFLNLVRNAAQaLAGSGGEIILRtrtqrqvtLGHPRHRLalRVSVIDNGPGIPPDLQDTIFYPMV------SGRENG 74
|
90 100 110
....*....|....*....|....*....|....*.
gi 518205580 562 TGLGLAIAKELVEAHHGKIWAKSKEGKgTAILFTLP 597
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
1-276 |
2.84e-13 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 72.36 E-value: 2.84e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 1 MNKVGFFRSIQLKFIIIYILLLLVAIQVIGSFFTNELEAELRENFFTSINDRVQLLSYNLEQAFNRERMEDGEGPTLQEE 80
Cdd:COG0840 1 LLILLLLLALLLALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 81 VQSIISDVDITSLEVINNQSRIIATNDYSSQGDIGKKTTRDMVQQALVTDSVQSGEMFDQATRQQVFVLAQPILDSDGVA 160
Cdd:COG0840 81 LLALLLALLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 161 VGVIYLKASMEGVNEQLQNINEIFLKGSILAVTVSAFIGILVARTITKPIIEMRRQAQTMARGDFTQKVNVYGRDEIGHL 240
Cdd:COG0840 161 AALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQL 240
|
250 260 270
....*....|....*....|....*....|....*.
gi 518205580 241 AETFNDLNSRLKHSYATIEEERRKLSSVLSNMSDGV 276
Cdd:COG0840 241 ADAFNRMIENLRELVGQVRESAEQVASASEELAASA 276
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
207-251 |
3.68e-13 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 64.00 E-value: 3.68e-13
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 518205580 207 TKPIIEMRRQAQTMARGDFTQKVNVYGRDEIGHLAETFNDLNSRL 251
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
336-580 |
4.32e-13 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 71.59 E-value: 4.32e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 336 TEEQESLVRaNFSTVLDDEDE-LTGFITVISDVTeqekieqerrdfvsnvsHELRTPLTTMRSYIEALTDGawedkeiap 414
Cdd:PRK10815 242 PRELTSLVR-NLNRLLKNERErYTKYRTTLTDLT-----------------HSLKTPLAVLQSTLRSLRSG--------- 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 415 KFLGVAQNE------TERMIRMVNDLLQLSKMDAKEHPLKKErtefINYFHGIIDRF---------------EMNVPEHI 473
Cdd:PRK10815 295 KQMSVEQAEpimleqISRISQQIGYYLHRASMRSEHNLLSRE----LHSVAPLLDNLtsalnkvyqrkgvniTLDISPEI 370
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 474 SlkrelpkgkfnvWL-DQDKMTQVLDNIISNAIKYSPEGGKITLRVENRRHHILVsiQDEGMGIAYDKLEKIFERFYRAD 552
Cdd:PRK10815 371 T------------FVgEKNDFMEVMGNVLDNACKYCLEFVEISARQTDEHLHIVV--EDDGPGIPESKRELIFDRGQRAD 436
|
250 260
....*....|....*....|....*...
gi 518205580 553 KARTrklgGTGLGLAIAKELVEAHHGKI 580
Cdd:PRK10815 437 TLRP----GQGLGLSVAREITEQYEGKI 460
|
|
| HAMP |
pfam00672 |
HAMP domain; |
201-253 |
4.17e-12 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 61.10 E-value: 4.17e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 518205580 201 LVARTITKPIIEMRRQAQTMARGDFTQKVNVYGRDEIGHLAETFNDLNSRLKH 253
Cdd:pfam00672 1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
495-597 |
8.04e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 62.40 E-value: 8.04e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 495 QVLDNIISNAIKYSPEGGKITLRVENRR---------------HHILVSIQDEGMGIAYDKLEKIFERFYRadkarTRKL 559
Cdd:cd16919 3 LAILNLAVNARDAMPEGGRLTIETSNQRvdadyalnyrdlipgNYVCLEVSDTGSGMPAEVLRRAFEPFFT-----TKEV 77
|
90 100 110
....*....|....*....|....*....|....*....
gi 518205580 560 G-GTGLGLAIAKELVEAHHGKIWAKSKEGKGTAILFTLP 597
Cdd:cd16919 78 GkGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
85-389 |
9.27e-12 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 67.60 E-value: 9.27e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 85 ISDVDITSLEVINNQSRIIATNDYSSQGDIGKKTTRDMVQQALVTDSVQSGEMFDQATRQQVFVLAQPILDSDGVAVGVI 164
Cdd:COG3850 20 ALLLLALLLLSLLALLLLLERTLLRLLSLLASAGLLAALLAALLLLLSLGLLALLLALLLLLLLLLLAALLSLLLLLLLL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 165 YLKASMEGVNEQLQNINE-IFLKGSILAVTVSAFIGILVARTITKPIIEMRRQAQTMARGDFTQKVNVYGRDEIGHLAET 243
Cdd:COG3850 100 LLLLLLLLLLLLAAAINRkLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARA 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 244 FNDLNSRLKHSYATIEEERRKLSSVLSNMSDGVIATDNVGAVTLMNEAAGRLIGHNPDEIIGENLLDIFQLEEKIVDITE 323
Cdd:COG3850 180 FNRMADELQELYAELEEEEELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELLALNIL 259
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 518205580 324 LHDSGSIIIDLSTEEQESLVRANFSTVLDDEDELTGFITVISDVTEQEKIEQERRDFVSNVSHELR 389
Cdd:COG3850 260 AGLLELLLALLLLLLASALLLLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQAIAN 325
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
489-597 |
1.22e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 61.78 E-value: 1.22e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 489 DQDKMTQVLDNIISNA---IKYSPEG-GKITLRVE-NRRHHILVSIQDEGMGIAYDKLEKIFERFYradkarTRKLGGTG 563
Cdd:cd16944 1 DTTQISQVLTNILKNAaeaIEGRPSDvGEVRIRVEaDQDGRIVLIVCDNGKGFPREMRHRATEPYV------TTRPKGTG 74
|
90 100 110
....*....|....*....|....*....|....
gi 518205580 564 LGLAIAKELVEAHHGKIWAKSKEGKGTAILFTLP 597
Cdd:cd16944 75 LGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
204-256 |
1.28e-11 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 59.57 E-value: 1.28e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 518205580 204 RTITKPIIEMRRQAQTMARGDFTQKVNVYGRDEIGHLAETFNDLNSRLKHSYA 256
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
146-597 |
1.61e-11 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 66.86 E-value: 1.61e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 146 VFVlaqPILDSDGVAVGVIYLKASMEGVNEQLQNINEIFLKGSILAVTVSAFIGILVARTItKPIIemrrqaqtmargdf 225
Cdd:PRK11086 147 VFT---PVYDENGKQIGVVAVGISLSEVTEQINESRWSIYWSILFGALVGLIGTVILVRVL-KRIL-------------- 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 226 tqkvnvYGRD--EIghlaetfndlnsrlkhsyATIEEERrklSSVLSNMSDGVIATDNVGAVTLMNEAAGRLIGHN---P 300
Cdd:PRK11086 209 ------FGLEpyEI------------------STLFEQR---QAMLQSIKEGVIAVDDRGEVTLINDEAKRLFNYKkglE 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 301 DEIIGENLLDIFQleekIVDITELHDSGSIIIDlstEEQeslvRANFSTVLDDE------DELTGFITVISDVTEQEKIE 374
Cdd:PRK11086 262 DDPLGTDVESWMP----VSRLKEVLRTGTPRRD---EEI----NINGRLLLTNTvpvrvnGEIIGAIATFRDKTEVRQLA 330
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 375 QErrdfvsnvshelrtpLTTMRSYIEALTdgawedkeiapkflgvAQNEtERMIRM--VNDLLQLSKMDAKEHPLKK--- 449
Cdd:PRK11086 331 QR---------------LDGMVNYADALR----------------AQSH-EFMNKLhvILGLLHLKSYDQLEDYILKtan 378
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 450 ERTEFINyfhGIIDRF-----------------EMNVPEHISLKRELPKgkfnvwLDQDKMTQVLDNIISN-------AI 505
Cdd:PRK11086 379 NYQEEIG---SLLGKIkspviagfllgkisrarELGITLIISEDSQLPD------SGDEDQVHELITILGNlienaleAV 449
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 506 KYSPEGG-KITLRVENRRHHILVSiqDEGMGIAYDKLEKIFERFYradkarTRKLGGTGLGLAIAKELVEAHHGKIWAKS 584
Cdd:PRK11086 450 GGEEGGEiSVSLHYRNGWLHCEVS--DDGPGIAPDEIDAIFDKGY------STKGSNRGVGLYLVKQSVENLGGSIAVES 521
|
490
....*....|...
gi 518205580 585 KEGKGTAILFTLP 597
Cdd:PRK11086 522 EPGVGTQFFVQIP 534
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
259-408 |
1.84e-11 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 64.66 E-value: 1.84e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 259 EEERRKLSSVLSNMSDGVIATDNVGAVTLMNEAAGRLIGHNPDEIIGENLLDIFQLEEKIVDITELHDSGSIIIDLSTEE 338
Cdd:COG2202 7 EESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLPPEDDDEFLELLRAALAGGGVWRGEL 86
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 518205580 339 -------QESLVRANFSTVLDDEDELTGFITVISDVTEQEKIEQERRDfvsnvSHELrtplttMRSYIEALTDGAWE 408
Cdd:COG2202 87 rnrrkdgSLFWVELSISPVRDEDGEITGFVGIARDITERKRAEEALRE-----SEER------LRLLVENAPDGIFV 152
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
258-379 |
4.37e-11 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 65.18 E-value: 4.37e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 258 IEEERRKLSSVLSNMSDGVIATDNVGAVTLMNEAAGRLIGHNPDEIIGENLLDIFQ-------LEEKIVDITELHDSGSI 330
Cdd:COG3829 6 LKELEEELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVTELIPnspllevLKTGKPVTGVIQKTGGK 85
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 518205580 331 IIDLSTEeqeslvranfSTVLDDEDELTGFITVISDVTEQEKIEQERRD 379
Cdd:COG3829 86 GKTVIVT----------AIPIFEDGEVIGAVETFRDITELKRLERKLRE 124
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
495-596 |
2.25e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 57.85 E-value: 2.25e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 495 QVLDNIISNAIKYSPEGGKITLRVENRRH--HILVSIQDEGMGIAYDKLEKIFERFYRadkarTRKLG-GTGLGLAIAKE 571
Cdd:cd16976 3 QVLMNLLQNALDAMGKVENPRIRIAARRLggRLVLVVRDNGPGIAEEHLSRVFDPFFT-----TKPVGkGTGLGLSISYG 77
|
90 100
....*....|....*....|....*
gi 518205580 572 LVEAHHGKIWAKSKEGKGTAILFTL 596
Cdd:cd16976 78 IVEEHGGRLSVANEEGAGARFTFDL 102
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
384-593 |
9.83e-10 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 61.63 E-value: 9.83e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 384 VSHELRTPLTTMRSYI-EALTDGAWEDKEIAPKFLGVAQNETERMIRMVNDLLQLSKMDakEHPLKkerteFINYFHGII 462
Cdd:COG4192 440 LAHELNQPLNAMSMYLfSAKKALEQENYAQLPTSLDKIEGLIERMDKIIKSLRQFSRKS--DTPLQ-----PVDLRQVIE 512
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 463 DRFEM----NVPEHISLKreLPkGKFNVWLDQDKMTQVLDNIISNAIKYSPEGGKITLRVENRRHHILVSIQDEGMGiaY 538
Cdd:COG4192 513 QAWELvesrAKPQQITLH--IP-DDLMVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNG--W 587
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 518205580 539 DKLEKIFERFYradkarTRKLGGTGLGLAIAKELVEAHHGKIW-AKSKEGKGTAIL 593
Cdd:COG4192 588 PLVDKLFTPFT------TTKEVGLGLGLSICRSIMQQFGGDLYlASTLERGAMVIL 637
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
421-598 |
6.44e-09 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 58.49 E-value: 6.44e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 421 QNETERMIRMVNDLLQLSKM----DAKEHPLKKE--------RTEFINYFHGIidRFEMNVPEHIsLKRELPKgkfnvwl 488
Cdd:COG2972 269 LEDPEEAEEMLEALSKLLRYslskGDELVTLEEEleliksylEIQKLRFGDRL--EVEIEIDEEL-LDLLIPK------- 338
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 489 dqdkMT-QVL-DNIISNAIKYSPEGGKITLRVENRRHHILVSIQDEGMGIAYDKLEKIFERFyradkarTRKLGGTGLGL 566
Cdd:COG2972 339 ----LIlQPLvENAIEHGIEPKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-------SSKGEGRGIGL 407
|
170 180 190
....*....|....*....|....*....|....*
gi 518205580 567 AIAKELVEAHHGK---IWAKSKEGKGTAILFTLPL 598
Cdd:COG2972 408 RNVRERLKLYYGEeygLEIESEPGEGTTVTIRIPL 442
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
236-377 |
3.46e-08 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 55.03 E-value: 3.46e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 236 EIGHLAETFNDLnSRLKHSYATIEEERRKLSSVLSNMSDGVIATDNVGAVTLMNEAAGRLIGHNPDEIIGENLLDIFQLE 315
Cdd:COG2202 111 EITGFVGIARDI-TERKRAEEALRESEERLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKSLLDLLHPE 189
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 316 EKIVD---ITELHDSGSIIIDL-----STEEQESLVRANFStVLDDEDELTGFITVISDVTEQEKIEQER 377
Cdd:COG2202 190 DRERLlelLRRLLEGGRESYELelrlkDGDGRWVWVEASAV-PLRDGGEVIGVLGIVRDITERKRAEEAL 258
|
|
| dCache_1 |
pfam02743 |
Cache domain; Double cache domain 1 covers the last three strands from the membrane distal ... |
43-241 |
5.51e-08 |
|
Cache domain; Double cache domain 1 covers the last three strands from the membrane distal PAS-like domain, the first two strands of the membrane proximal domain, and the connecting elements between the two domains. This domain when present in chemoreceptors recognize several signals such as proteinogenic amino acids, GABA, Histamine and polyamines, decanoic acid, Autoinducer-2, purine derivatives, quaternary amines, citrate and taurine, among others. When associated with histidine kinases, it recognizes C3/C4-dicarboxylic acids, Spermine, guanosine and Autoinducer-2 (Mantilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1 https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 460673 [Multi-domain] Cd Length: 237 Bit Score: 53.88 E-value: 5.51e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 43 ENFFTSINDRVQLLSynlEQAFNRERMEDGEGPTLQEEVQSIISDVDITSLEVINNQSRIIATNDYSSQGDIGKKTTRDM 122
Cdd:pfam02743 23 ESYLDSLEEILELLA---SNPDLQDLLSAPAEEELAKLESLLRSNPGISSIYLVDADGRVLASSDESPSYPGLDVSERPW 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 123 VQQALVTD----SVQSGEMFDQATRQQVFVLAQPILDSDGVAVGVIYLKASMEGVNEQLQNINeiflkgsiLAVTVSAFI 198
Cdd:pfam02743 100 YKEALKGGggiiWVFSSPYPSSESGEPVLTIARPIYDDDGEVIGVLVADLDLDTLQELLSQIK--------LGEGGYVFI 171
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 518205580 199 ----GILVARTITKPIIEMRRQ----AQTMARGDFTQKVNVYGRDEIGHLA 241
Cdd:pfam02743 172 vdsdGRILAHPLGKNLRSLLAPflgkSLADALPGSGITEIAVDLDGEDYLV 222
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
1-444 |
6.21e-08 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 55.89 E-value: 6.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 1 MNKVGFFRSIQLKFIIIYILLLLVAIQVIGSFFTNELEAELRENFFTSINDRVQLLSYNLEQAFNRERMEDGEGPTLQEE 80
Cdd:COG2770 31 ISLRLLLALLLLLLLLLALLLLLLLLLLLLLAALVLLALLLAAALLLLLLLLSLVALAALLLALLLLLLLALLLLLAALL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 81 VQSIISDVDITSLEVINNQSRIIATNDYSSQGDIGKKTTRDMVQQALVTDSVQSGEMFDQATRQQVFVLAQPILDSDGVA 160
Cdd:COG2770 111 LLLLLAALALLLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAALALALGAGELLLLADLAAAIAALLAAL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 161 VGVIYLKASMEGVNEQLQNINEIFLKGSILAVTVSAFIGILVARTITKPIIEMRRQAQTMARGDFTQKVNVYGRDEIGHL 240
Cdd:COG2770 191 LLLLLGGLLLVVLLEAALAALLLLLLLALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKDEIGEL 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 241 AETFNDLNSRLKHSYATIEEERRKLSSVLSNMSDGVIATDNVGAVTLMNEAAGRLIGHNPDEIIGENLLDIFQLEEKIVD 320
Cdd:COG2770 271 ARAFNRMADSLRESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADL 350
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 321 ITELHDSGSIIIDLSTEEQESLVRANFSTVLDDEDELTGFITVISDVTEQEKIEQERRDFVSNVSHELRTPLTTMRSYIE 400
Cdd:COG2770 351 LLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAAAAAA 430
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 518205580 401 ALTDGAWEDKEIAPKFLGVAQNETERMIRMVNDLLQLSKMDAKE 444
Cdd:COG2770 431 AEAAAAALELAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLL 474
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
501-597 |
7.05e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 50.24 E-value: 7.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 501 ISNAIKYSPeGGKITLRVENRRHHILVSIQDEGMGIAYDklekiferfyradkartRKLGGTGLGLAIAKELVEAHHGKI 580
Cdd:cd16917 9 LTNALKHAG-ASRVRVTLSYTADELTLTVVDDGVGFDGP-----------------APPGGGGFGLLGMRERAELLGGTL 70
|
90
....*....|....*..
gi 518205580 581 WAKSKEGKGTAILFTLP 597
Cdd:cd16917 71 TIGSRPGGGTRVTARLP 87
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
496-597 |
8.48e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 50.36 E-value: 8.48e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 496 VLDNIISNAIKY---SPEGGK---ITLRVENRRHHILVSiqDEGMGIAYDKLEKIFERFYRadkarTRKLGGTGLGLAIA 569
Cdd:cd16915 4 IVGNLIDNALDAlaaTGAPNKqveVFLRDEGDDLVIEVR--DTGPGIAPELRDKVFERGVS-----TKGQGERGIGLALV 76
|
90 100
....*....|....*....|....*...
gi 518205580 570 KELVEAHHGKIWAKSKEGKGTAILFTLP 597
Cdd:cd16915 77 RQSVERLGGSITVESEPGGGTTFSIRIP 104
|
|
| PAS_9 |
pfam13426 |
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ... |
283-369 |
1.53e-07 |
|
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463873 [Multi-domain] Cd Length: 93 Bit Score: 49.38 E-value: 1.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 283 GAVTLMNEAAGRLIGHNPDEIIGENLLDIFQLEEKIVDITELHDSGSIIIDLSTEEQES-----LVRANFSTVLDDEDEL 357
Cdd:pfam13426 2 GRIIYVNDAALRLLGYTREELLGKSITDLFAEPEDSERLREALREGKAVREFEVVLYRKdgepfPVLVSLAPIRDDGGEL 81
|
90
....*....|..
gi 518205580 358 TGFITVISDVTE 369
Cdd:pfam13426 82 VGIIAILRDITE 93
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
501-598 |
3.17e-07 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 51.93 E-value: 3.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 501 ISNAIKYSPeGGKITLRVENRRHHILVSIQDEGMGIAydklekiferfyradkarTRKLGGTGLGLAIAKELVEAHHGKI 580
Cdd:COG4585 171 LTNALKHAG-ATRVTVTLEVDDGELTLTVRDDGVGFD------------------PEAAPGGGLGLRGMRERAEALGGTL 231
|
90
....*....|....*...
gi 518205580 581 WAKSKEGKGTAILFTLPL 598
Cdd:COG4585 232 TIGSAPGGGTRVRATLPL 249
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
509-597 |
3.43e-07 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 50.66 E-value: 3.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 509 PEGGKITLRVENRRHHILVSIQDEGMGIAYDK-LEKIFERFYRADKARTR----------------------KLGGTGLG 565
Cdd:cd16916 67 PPEGTITLRAEHQGNQVVIEVSDDGRGIDREKiREKAIERGLITADEAATlsddevlnlifapgfstaeqvtDVSGRGVG 146
|
90 100 110
....*....|....*....|....*....|..
gi 518205580 566 LAIAKELVEAHHGKIWAKSKEGKGTAILFTLP 597
Cdd:cd16916 147 MDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
263-312 |
5.36e-07 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 47.01 E-value: 5.36e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 518205580 263 RKLSSVLSNMSDGVIATDNVGAVTLMNEAAGRLIGHNPDEIIGENLLDIF 312
Cdd:smart00091 1 ERLRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELI 50
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
471-597 |
6.59e-07 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 52.37 E-value: 6.59e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 471 EHISLKRELPKGKFNVWLDQDKMTQVLDNIISNAIKYSPEGGKITLRVENRR---------------HHILVSIQDEGMG 535
Cdd:PRK13557 256 DAVTIETDLAPDLWNCRIDPTQAEVALLNVLINARDAMPEGGRVTIRTRNVEiededlamyhglppgRYVSIAVTDTGSG 335
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 518205580 536 IAYDKLEKIFERFYradkaRTRKLG-GTGLGLAIAKELVEAHHGKIWAKSKEGKGTAILFTLP 597
Cdd:PRK13557 336 MPPEILARVMDPFF-----TTKEEGkGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFP 393
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
263-367 |
2.21e-06 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 46.64 E-value: 2.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 263 RKLSSVLSNMSDGVIATDNVGAVTLMNEAAGRLIGHNPDEIIGENLLD-------------IFQL-----EEKIVDITEL 324
Cdd:pfam00989 1 EDLRAILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDlipeeddaevaelLRQAllqgeESRGFEVSFR 80
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 518205580 325 HDSGSIIidlsteeqesLVRANFSTVLDDEDELTGFITVISDV 367
Cdd:pfam00989 81 VPDGRPR----------HVEVRASPVRDAGGEILGFLGVLRDI 113
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
272-367 |
3.66e-06 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 45.70 E-value: 3.66e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 272 MSDGVIATDNVGAVTLMNEAAGRLIGHNPDEIIGENLLDIF------QLEEKIVDITELHDSGSIIIDLSTEEQESL-VR 344
Cdd:cd00130 1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIhpedreELRERLENLLSGGEPVTLEVRLRRKDGSVIwVL 80
|
90 100
....*....|....*....|...
gi 518205580 345 ANFSTVLDDEDELTGFITVISDV 367
Cdd:cd00130 81 VSLTPIRDEGGEVIGLLGVVRDI 103
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
369-598 |
4.56e-06 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 49.93 E-value: 4.56e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 369 EQEKIEQERRDFVSNVSHELRTPLTTMRSYIEALTDGAWEDKEIAPkfLGVAQNETERMIRMVNDLLQLSKMDAKEhpLK 448
Cdd:PRK10618 442 EYEKNQQARKAFLQNIGDELKQPLQSLAQLAAQLRQTSDEEQQQPE--LDQLAEQSDVLVRLVDNIQLLNMLETQD--WK 517
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 449 KERTEFinYFHGIIDrfemnvpeHIsLKRELP----KG---KFNVWLDQDKM----TQVLDNIISNAIKYS---PEGGKI 514
Cdd:PRK10618 518 PEQELF--SLQDLID--------EV-LPEVLPaikrKGlqlLIHNHLKAEQLrigdRDALRKILLLLLNYAittTAYGKI 586
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 515 TLRV---ENRRHHILVSIQDEGMGIAYDKLEKI---------FERFYRAD-------KARTRKLGGTglgLAIakelvea 575
Cdd:PRK10618 587 TLEVdqdESSPDRLTIRILDTGAGVSIKELDNLhfpflnqtqGDRYGKASgltfflcNQLCRKLGGH---LTI------- 656
|
250 260
....*....|....*....|...
gi 518205580 576 hhgkiwaKSKEGKGTAILFTLPL 598
Cdd:PRK10618 657 -------KSREGLGTRYSIHLKM 672
|
|
| PRK10600 |
PRK10600 |
nitrate/nitrite two-component system sensor histidine kinase NarX; |
183-260 |
2.02e-05 |
|
nitrate/nitrite two-component system sensor histidine kinase NarX;
Pssm-ID: 182581 [Multi-domain] Cd Length: 569 Bit Score: 47.36 E-value: 2.02e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 518205580 183 IFLKGSILAVTVsafigILVARTITKPIIEMRRQAQTMARGDFTQKVNVYGRDEIGHLAETFNDLNSRLKHSYATIEE 260
Cdd:PRK10600 131 AVFMALLLVFTI-----IWLRRRLLQPWRQLLSMANAVSHRDFTQRANISGRDEMAMLGTALNNMSAELAESYAVLEQ 203
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
495-597 |
2.09e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 43.95 E-value: 2.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 495 QVL-DNIISNAIKYSPEGGKITLRVENRRHHILVSIQDEGMGIAYDKLEKIFERFYRADKartrklgGTGLGLAIAKELV 573
Cdd:cd16957 7 QVLvENAIRHAFPKRKENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGKTTVTSEK-------GTGTALENLNRRL 79
|
90 100
....*....|....*....|....*..
gi 518205580 574 EAHHGKIWA---KSKEGKGTAILFTLP 597
Cdd:cd16957 80 IGLFGSEAClhiESEVHGGTEVWFVIP 106
|
|
| sensory_box |
TIGR00229 |
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ... |
259-377 |
2.82e-05 |
|
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]
Pssm-ID: 272971 [Multi-domain] Cd Length: 124 Bit Score: 43.82 E-value: 2.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 259 EEERrkLSSVLSNMSDGVIATDNVGAVTLMNEAAGRLIGHNPDEIIGENLLDIF--QLEEKIVDITELHDSGSIIIdlsT 336
Cdd:TIGR00229 1 SEER--YRAIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRNVLELIpeEDREEVRERIERRLEGEPEP---V 75
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 518205580 337 EEQESLVRANFSTV--------LDDEDELTGFITVISDVTEQEKIEQER 377
Cdd:TIGR00229 76 SEERRVRRKDGSEIwvevsvspIRTNGGELGVVGIVRDITERKEAEEAL 124
|
|
| PAS_4 |
pfam08448 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
269-371 |
1.63e-04 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain is associated to signalling systems and works as a signal sensor domain. It recognizes differently substituted aromatic hydrocarbons, oxygen, different dodecanoic acids, autoinducers, 3,5-dimethyl-pyrazin-2-ol and N-alanyl-aminoacetone (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 312075 [Multi-domain] Cd Length: 110 Bit Score: 41.25 E-value: 1.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 269 LSNMSDGVIATDNVGAVTLMNEAAGRLIGHNPDEIIGENLLDIF------QLEEKIVDITELHDSGSIIIDLSTEEQESL 342
Cdd:pfam08448 1 LDSLPDALAVLDPDGRVRYANAAAAELFGLPPEELLGKTLAELLppedaaRLERALRRALEGEEPIDFLEELLLNGEERH 80
|
90 100
....*....|....*....|....*....
gi 518205580 343 VRANFSTVLDDEDELTGFITVISDVTEQE 371
Cdd:pfam08448 81 YELRLTPLRDPDGEVIGVLVISRDITERR 109
|
|
| PDC1_HK_sensor |
cd18773 |
first PDC (PhoQ/DcuS/CitA) domain of methyl-accepting chemotaxis proteins, diguanylate-cyclase ... |
49-164 |
3.95e-04 |
|
first PDC (PhoQ/DcuS/CitA) domain of methyl-accepting chemotaxis proteins, diguanylate-cyclase and similar domains; Histidine kinase (HK) receptors are part of two-component systems (TCS) in bacteria that play a critical role for sensing and adapting to environmental changes. Typically, HK receptors contain an extracellular sensing domain flanked by two transmembrane helices, an intracellular dimerization histidine phosphorylation domain (DHp), and a C-terminal kinase domain, with many variations on this theme. HK receptors in this family contain double PDC (PhoQ/DcuS/CitA) sensor domains. Signals detected by the sensor domain are transmitted through DHp to the kinase domain, resulting in the phosphorylation of a conserved histidine residue in DHp; phosphotransfer to a conserved aspartate in its cognate response regulator (RR) follows, which leads to the activation of genes for downstream cellular responses. The HK family includes not just histidine kinase receptors but also sensors for chemotaxis proteins and diguanylate cyclase receptors, implying a combinatorial molecular evolution.
Pssm-ID: 350341 [Multi-domain] Cd Length: 125 Bit Score: 40.62 E-value: 3.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 49 INDRVQLLSYNLEQAFNRERMEDGEGPTLQEEVQSIISDV-DITSLEVINNQSRIIATNDYSSQG-DIGKKTTRDMVQQA 126
Cdd:cd18773 1 LEEADLLLRSLASALEALAALGSADREELQALLRRLLERNpEISGIYVVDADGRVVASSDRDPGGgDDDDDRDRFWYQAA 80
|
90 100 110
....*....|....*....|....*....|....*....
gi 518205580 127 LVTDSVQSGE-MFDQATRQQVFVLAQPILDSDGVAVGVI 164
Cdd:cd18773 81 KATGKLVISEpYISRVTGKPVITLSRPIRDADGRFIGVV 119
|
|
| PAS_8 |
pfam13188 |
PAS domain; PAS domains are involved in many signalling proteins where they are used as a ... |
263-320 |
6.82e-04 |
|
PAS domain; PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. This domain recognizes oxygen and CO (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463802 [Multi-domain] Cd Length: 65 Bit Score: 38.30 E-value: 6.82e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 518205580 263 RKLSSVLSNMSDGVIATDNVGAVTLMNEAAGRLIGHNPDEIIGENLLDIFQLEEKIVD 320
Cdd:pfam13188 1 ERLRALFESSPDGILVLDEGGRIIYVNPAALELLGYELLGELLGELLDLLDPLLEDAL 58
|
|
| PRK11359 |
PRK11359 |
cyclic-di-GMP phosphodiesterase; Provisional |
260-379 |
8.44e-04 |
|
cyclic-di-GMP phosphodiesterase; Provisional
Pssm-ID: 183097 [Multi-domain] Cd Length: 799 Bit Score: 42.45 E-value: 8.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 260 EERRKLSSVLSNMSDGVIATDNVGAVTLMNEAAGRLIGHNPDEIIGENLLDIFQLEEKIVD----ITEL-----HDSGSI 330
Cdd:PRK11359 133 EQTRQLIIAVDHLDRPVIVLDPERRIVQCNRAFTEMFGYCISEASGMQPDTLLNIPEFPADnrirLQQLlwktaRDQDEF 212
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 518205580 331 IIdLSTEEQESLVRANFSTVLDDEDELTGFITVISDVTEQEKIEQERRD 379
Cdd:PRK11359 213 LL-LTRTGEKIWIKASISPVYDVLAHLQNLVMTFSDITEERQIRQLEGN 260
|
|
| PRK13560 |
PRK13560 |
hypothetical protein; Provisional |
252-523 |
1.20e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 106506 [Multi-domain] Cd Length: 807 Bit Score: 41.97 E-value: 1.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 252 KHSYATIEEERRKLSSVLSNMSDGVIATDNVGAVTLMNEAAGRLIGHNPDEIIGENLLDiFQLEEKIVDITELH-----D 326
Cdd:PRK13560 193 KRAEERIDEALHFLQQLLDNIADPAFWKDEDAKVFGCNDAACLACGFRREEIIGMSIHD-FAPAQPADDYQEADaakfdA 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 327 SGSIII-------DLSTEEQEslVRANFSTVLDDEDELTGFITVISDVTEQEKIEQerrdfvsnvshELRTPLTTMRSYI 399
Cdd:PRK13560 272 DGSQIIeaefqnkDGRTRPVD--VIFNHAEFDDKENHCAGLVGAITDISGRRAAER-----------ELLEKEDMLRAII 338
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 400 EALTDGAWeDKEIAPKFLGVAQNETERMirmvndlLQLSKMDAKEHPLKKERTEfinyfhgiidrfemnvpehisLKREL 479
Cdd:PRK13560 339 EAAPIAAI-GLDADGNICFVNNNAAERM-------LGWSAAEVMGKPLPGMDPE---------------------LNEEF 389
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 518205580 480 PKGKFNVWLDQDKMTQVLDNIISNAIKyspeGGKITLRVENRRH 523
Cdd:PRK13560 390 WCGDFQEWYPDGRPMAFDACPMAKTIK----GGKIFDGQEVLIE 429
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
263-603 |
1.20e-03 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 41.74 E-value: 1.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 263 RKLSSVLSNMSDGVIATDNVGAVTLMNEAAGRLIG--HNPDEIIGE------NLLDIF--QLEEKIVDITELHDSGSIIi 332
Cdd:PRK15053 222 RQQEALFSSVYEGLIAVDPHGYITAINRNARKMLGlsSPGRQWLGKpiaevvRPADFFteQIDEKRQDVVANFNGLSVI- 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 333 dlsteeqeslvrANFSTVLDDEDELTGFITVISdvteQEKIeqerrdfvsnvsHELRTPLTTMRSYIEALTDGAWEDKEI 412
Cdd:PRK15053 301 ------------ANREAIRSGDDLLGAIISFRS----KDEI------------STLNAQLTQIKQYVESLRTLRHEHLNW 352
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 413 APKFLGVAQ-NETERMIRMVNDLLQlskmdAKEHPLKKERTEFIN-----YFHGIIDR-----FEMNVPEHISLKReLPK 481
Cdd:PRK15053 353 MSTLNGLLQmKEYDRVLEMVQGESQ-----AQQQLIDSLREAFADrqvagLLFGKVQRarelgLKMVIVPGSQLSQ-LPP 426
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 482 GkfnvwLDQDKMTQVLDNIISNAIKYS---PEGGK-ITLRVENRRHHILVSIQDEGMGIAYDKLEKIFErfyRADKARTR 557
Cdd:PRK15053 427 G-----LDSTEFAAIVGNLLDNAFEASlrsDEGNKiVELFLSDEGDDVVIEVADQGCGVPESLRDKIFE---QGVSTRAD 498
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 518205580 558 KLGGTGLGLAIAKELVEAHHGKIWAKSKEGKGTaiLFTLPLMNQKR 603
Cdd:PRK15053 499 EPGEHGIGLYLIASYVTRCGGVITLEDNDPCGT--LFSIFIPKVKP 542
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
120-598 |
1.39e-03 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 41.43 E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 120 RDMVQQALVTDSVQSGEMFDQATRQQVFVLAQPILDSDGVAVGVIYLKASMEGVNEQLQNINEIFLKGSILAVTVSAFIG 199
Cdd:COG3920 34 LALLLLALLLLALLLASALLALLALSAAALAAALAVALAAAVGAAAALLALLVLLLLLLLAAAALALALLLAALAGLLLL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 200 ILVARTITKPIIEMRRQAQTMARGDFTQKVNVYGRDEIGHLAETFNDLNSRLKHSYATIEEERRKLSSVLSNMSDGVIAT 279
Cdd:COG3920 114 AALLLLRLVALLAALALLALLLLLLLLLAILALAELAVALAELAAALLLLAEELAALRLAAAALLLLLAALLDLGLALAA 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 280 DNVGAVTLMNEAAGRLIGHNPDEIIGENLLDIFQLEEKIVDITELHDSGSIIIDLSTEEQESLVRANFSTVLDDEDELTG 359
Cdd:COG3920 194 LAAAALLALLLALELLLALLLLLLLLLALLLVLLAALLRLRAAVLEELERRRRARGLGRLLLLLLLLLLLLRALLLLAAG 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 360 FITVISDVTEQE----KIEQERRDFVSNVSHELRTPLTTMRSYIeALTDGAWEDKEIApKFLGVAQNeteRM--IRMVND 433
Cdd:COG3920 274 IRLVITERKRAEeeleASLEEKELLLRELHHRVKNNLQVVSSLL-RLQARRADDPEAR-EALEESQN---RIqaLALVHE 348
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 434 LLQLSKmdakehplKKERTEFINYFHGIIDRF-EMNVPEHISLKRELPkgkfNVWLDQDKMTQ---VLDNIISNAIKY-- 507
Cdd:COG3920 349 LLYQSE--------DWEGVDLRDYLRELLEPLrDSYGGRGIRIELDGP----DVELPADAAVPlglILNELVTNALKHaf 416
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 508 -SPEGGKITLRVENRRHHILVSIQDEGMGIAydklekiferfyradkARTRKLGGTGLGLAIAKELVEAHHGKIwaKSKE 586
Cdd:COG3920 417 lSGEGGRIRVSWRREDGRLRLTVSDNGVGLP----------------EDVDPPARKGLGLRLIRALVRQLGGTL--ELDR 478
|
490
....*....|..
gi 518205580 587 GKGTAILFTLPL 598
Cdd:COG3920 479 PEGTRVRITFPL 490
|
|
| HATPase_EL346-LOV-HK-like |
cd16951 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
488-597 |
1.76e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.
Pssm-ID: 340427 [Multi-domain] Cd Length: 131 Bit Score: 38.94 E-value: 1.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 488 LDQDKMTQ---VLDNIISNAIKYS---PEGGKITLRVENRRHHILVSIQDEGMGIAYDklekiferfyrADKARTRKlgg 561
Cdd:cd16951 32 VSSEVATAiglVVNELLQNALKHAfsdREGGTITIRSVVDGDYLRITVIDDGVGLPQD-----------EDWPNKGS--- 97
|
90 100 110
....*....|....*....|....*....|....*.
gi 518205580 562 tgLGLAIAKELVEAHHGKIWAKSKEGKGTAILFTLP 597
Cdd:cd16951 98 --LGLQIVRSLVEGELKAFLEVQSAENGTRVNIDIP 131
|
|
| PRK09776 |
PRK09776 |
putative diguanylate cyclase; Provisional |
260-376 |
2.94e-03 |
|
putative diguanylate cyclase; Provisional
Pssm-ID: 182070 [Multi-domain] Cd Length: 1092 Bit Score: 40.81 E-value: 2.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 260 EERRKLSSVLSNMSDGVIATDNVGAVTLMNEAAGRLIGHNPDEIIGENLLDIFQ------------------------LE 315
Cdd:PRK09776 533 QEKERLHITLDSIGEAVVCTDMAMKVTFMNPVAEKMTGWTQEEALGVPLLTVLHitfgdngplmeniyscltsrsaayLE 612
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 518205580 316 EKIVDIT---ELHDSGSIIIDLSTEEQEslvraNFSTVLddedeltgfitVISDVTEQEKIEQE 376
Cdd:PRK09776 613 QDVVLHCrsgGSYDVHYSITPLSTLDGE-----NIGSVL-----------VIQDVTESRKMLRQ 660
|
|
| PDC1_DGC_like |
cd12914 |
first PDC (PhoQ/DcuS/CitA) domain of diguanylate-cyclase and similar domains; Members of this ... |
51-164 |
6.14e-03 |
|
first PDC (PhoQ/DcuS/CitA) domain of diguanylate-cyclase and similar domains; Members of this subfamily display varying domain architectures but all contain double PDC (PhoQ/DcuS/CitA) sensor domains. This model represents the first PDC domain of Diguanylate-cyclases (DGCs), Histidine kinases (HKs), and other similar domains. Many members of this subfamily contain a C-terminal DGC (also called GGDEF) domain. DGCs regulate the turnover of cyclic diguanosine monophosphate. HK receptors are part of two-component systems (TCS) in bacteria that play a critical role for sensing and adapting to environmental changes. Typically, HK receptors contain an extracellular sensing domain flanked by two transmembrane helices, an intracellular dimerization histidine phosphorylation domain (DHp), and a C-terminal kinase domain, with many variations on this theme. In the case of HKs, signals detected by the sensor domain are transmitted through DHp to the kinase domain, resulting in the phosphorylation of a conserved histidine residue in DHp; phosphotransfer to a conserved aspartate in its cognate response regulator (RR) follows, which leads to the activation of genes for downstream cellular responses.
Pssm-ID: 350339 Cd Length: 123 Bit Score: 36.98 E-value: 6.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 51 DRVQLLSYNLEQAFNRERMEDGEGPTLQEEVQSIISDV-DITSLEVINNQSRIIATNDYSS--QGDIGKkttRDMVQQAL 127
Cdd:cd12914 2 DEADLLLRSLADDLEARGAASADPAALQALLRRLLARLpEVRSIFVVDADGRVVASSGPGPapGLDVSD---RDYFQAAR 78
|
90 100 110
....*....|....*....|....*....|....*....
gi 518205580 128 VTDS--VQSGEMFDQATRQQVFVLAQPILDSDGVAVGVI 164
Cdd:cd12914 79 AGGGglFISEPVISRVTGKPVIPLSRPIRDADGRFAGVV 117
|
|
| HATPase_PDK-like |
cd16929 |
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ... |
514-590 |
7.63e-03 |
|
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.
Pssm-ID: 340406 [Multi-domain] Cd Length: 169 Bit Score: 37.71 E-value: 7.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 518205580 514 ITLRVENRRHHILVSIQDEGMGIAYDKLEKIFERFY----------RADKARTRK---LGGTGLGLAIAKELVEAHHGKI 580
Cdd:cd16929 73 IKVTVAKGDEDLTIKISDRGGGIPREDLARLFSYMYstapqpslddFSDLISGTQpspLAGFGYGLPMSRLYAEYFGGDL 152
|
90
....*....|
gi 518205580 581 WAKSKEGKGT 590
Cdd:cd16929 153 DLQSMEGYGT 162
|
|
| |
