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Conserved domains on  [gi|517999043|ref|WP_019169251|]
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PTS sugar transporter subunit IIA [Staphylococcus intermedius]

Protein Classification

PTS sugar transporter subunit IIA( domain architecture ID 10004459)

PTS sugar transporter subunit IIA is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system that catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PtsN COG1762
Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate ...
1-147 3.51e-31

Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism, Signal transduction mechanisms];


:

Pssm-ID: 441368 [Multi-domain]  Cd Length: 150  Bit Score: 109.17  E-value: 3.51e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517999043   1 MSLEMLTEDKINVKEYVATWEEAIKVAAQPLLDQAY--FNPSYVDAMIDSVYRHGPYIviAPEIAIAHARPNGnVNKVGL 78
Cdd:COG1762    2 MLSDLLTPELILLDLEASSKEEAIEELAELLAEKGYvlDKEEYLEALLEREELGSTGI--GPGIAIPHARPEG-VKKPGI 78
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 517999043  79 SLLKLHRHIDFGEKSHY-ASLIFVFSA--VDTHSHLDILQSLARILGDVTTVNRLMQSQNAAEIVSIIKGVE 147
Cdd:COG1762   79 AVARLKEPVDFGAMDGEpVDLVFLLAApeDDSEEHLKLLAELARLLSDEEFREKLLNAKSPEEILELLKEAE 150
 
Name Accession Description Interval E-value
PtsN COG1762
Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate ...
1-147 3.51e-31

Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 441368 [Multi-domain]  Cd Length: 150  Bit Score: 109.17  E-value: 3.51e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517999043   1 MSLEMLTEDKINVKEYVATWEEAIKVAAQPLLDQAY--FNPSYVDAMIDSVYRHGPYIviAPEIAIAHARPNGnVNKVGL 78
Cdd:COG1762    2 MLSDLLTPELILLDLEASSKEEAIEELAELLAEKGYvlDKEEYLEALLEREELGSTGI--GPGIAIPHARPEG-VKKPGI 78
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 517999043  79 SLLKLHRHIDFGEKSHY-ASLIFVFSA--VDTHSHLDILQSLARILGDVTTVNRLMQSQNAAEIVSIIKGVE 147
Cdd:COG1762   79 AVARLKEPVDFGAMDGEpVDLVFLLAApeDDSEEHLKLLAELARLLSDEEFREKLLNAKSPEEILELLKEAE 150
PTS_IIA_fru cd00211
PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: ...
6-143 7.39e-31

PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.


Pssm-ID: 238129 [Multi-domain]  Cd Length: 136  Bit Score: 107.65  E-value: 7.39e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517999043   6 LTEDKINVKEYVATWEEAIKVAAQPLLDQAYFNPSYVDAMIDSVyRHGPYIVIaPEIAIAHARPNGnVNKVGLSLLKLHR 85
Cdd:cd00211    1 LTKENIRLNLKAKSKEEAIEELAQLLVAAGYVEEEYIEALLERE-KEGSTGIG-NGIAIPHAKSEA-VKKPGIAVLRLKE 77
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 517999043  86 HIDFGEKS-HYASLIFVFSAVDTHSHLDILQSLARILGDVTTVNRLMQSQNAAEIVSII 143
Cdd:cd00211   78 PVDFGSLDgQPVHLIFLLAAPDSNEHLKALSQLARLLSDEEFVEQLLNAQSKEEILALL 136
PTS_EIIA_2 pfam00359
Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2;
6-144 3.53e-29

Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2;


Pssm-ID: 459780 [Multi-domain]  Cd Length: 139  Bit Score: 103.44  E-value: 3.53e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517999043    6 LTEDKINVKEYVATWEEAIKVAAQPLLDQAYFNPSYVDAMIDSVYRHGPYIVIapEIAIAHARPNGnVNKVGLSLLKLHR 85
Cdd:pfam00359   2 LDKELIFLNLEAKSKEEAIEFLADKLVEAGYVEPAYLEAILEREKEGSTGIGN--GIAIPHARSEA-VKKPGIAVLTLKE 78
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 517999043   86 HIDFGEKS-HYASLIFVFSAVDTHS-HLDILQSLARILGDVTTVNRLMQSQNAAEIVSIIK 144
Cdd:pfam00359  79 PVDFGSEDgKPVKLIFLLAAPDNEAsHLKILSQLARLLQDEEFVEKLLKAKDPEEILEILK 139
cmtB PRK09854
PTS mannitol transporter subunit IIA;
8-143 1.35e-23

PTS mannitol transporter subunit IIA;


Pssm-ID: 182114 [Multi-domain]  Cd Length: 147  Bit Score: 89.67  E-value: 1.35e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517999043   8 EDKINVKEYVATWEEAIKVAAQPLLDQAYFNPSYVDAMIDSVYRHGPYIVIAPEIAIAHARPNGNVNKVGLSLLKLHRHI 87
Cdd:PRK09854   9 ESSISVIHSAKDWQEAIDFSMVSLLDKNYISENYIQAIKDSTINNGPYYILAPGVAMPHARPECGALKTGMSLTLLEQGV 88
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 517999043  88 DFGEKSHYASLIFVFSAVDTHSHLDILQSLARILGDVTTVNRLMQSQNAAEIVSII 143
Cdd:PRK09854  89 YFPGNDEPIKLLIGLSAADADSHIGAIQALSELLCEEEILEQLLTASSEKQLADII 144
 
Name Accession Description Interval E-value
PtsN COG1762
Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate ...
1-147 3.51e-31

Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 441368 [Multi-domain]  Cd Length: 150  Bit Score: 109.17  E-value: 3.51e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517999043   1 MSLEMLTEDKINVKEYVATWEEAIKVAAQPLLDQAY--FNPSYVDAMIDSVYRHGPYIviAPEIAIAHARPNGnVNKVGL 78
Cdd:COG1762    2 MLSDLLTPELILLDLEASSKEEAIEELAELLAEKGYvlDKEEYLEALLEREELGSTGI--GPGIAIPHARPEG-VKKPGI 78
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 517999043  79 SLLKLHRHIDFGEKSHY-ASLIFVFSA--VDTHSHLDILQSLARILGDVTTVNRLMQSQNAAEIVSIIKGVE 147
Cdd:COG1762   79 AVARLKEPVDFGAMDGEpVDLVFLLAApeDDSEEHLKLLAELARLLSDEEFREKLLNAKSPEEILELLKEAE 150
PTS_IIA_fru cd00211
PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: ...
6-143 7.39e-31

PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.


Pssm-ID: 238129 [Multi-domain]  Cd Length: 136  Bit Score: 107.65  E-value: 7.39e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517999043   6 LTEDKINVKEYVATWEEAIKVAAQPLLDQAYFNPSYVDAMIDSVyRHGPYIVIaPEIAIAHARPNGnVNKVGLSLLKLHR 85
Cdd:cd00211    1 LTKENIRLNLKAKSKEEAIEELAQLLVAAGYVEEEYIEALLERE-KEGSTGIG-NGIAIPHAKSEA-VKKPGIAVLRLKE 77
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 517999043  86 HIDFGEKS-HYASLIFVFSAVDTHSHLDILQSLARILGDVTTVNRLMQSQNAAEIVSII 143
Cdd:cd00211   78 PVDFGSLDgQPVHLIFLLAAPDSNEHLKALSQLARLLSDEEFVEQLLNAQSKEEILALL 136
PTS_EIIA_2 pfam00359
Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2;
6-144 3.53e-29

Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2;


Pssm-ID: 459780 [Multi-domain]  Cd Length: 139  Bit Score: 103.44  E-value: 3.53e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517999043    6 LTEDKINVKEYVATWEEAIKVAAQPLLDQAYFNPSYVDAMIDSVYRHGPYIVIapEIAIAHARPNGnVNKVGLSLLKLHR 85
Cdd:pfam00359   2 LDKELIFLNLEAKSKEEAIEFLADKLVEAGYVEPAYLEAILEREKEGSTGIGN--GIAIPHARSEA-VKKPGIAVLTLKE 78
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 517999043   86 HIDFGEKS-HYASLIFVFSAVDTHS-HLDILQSLARILGDVTTVNRLMQSQNAAEIVSIIK 144
Cdd:pfam00359  79 PVDFGSEDgKPVKLIFLLAAPDNEAsHLKILSQLARLLQDEEFVEKLLKAKDPEEILEILK 139
cmtB PRK09854
PTS mannitol transporter subunit IIA;
8-143 1.35e-23

PTS mannitol transporter subunit IIA;


Pssm-ID: 182114 [Multi-domain]  Cd Length: 147  Bit Score: 89.67  E-value: 1.35e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517999043   8 EDKINVKEYVATWEEAIKVAAQPLLDQAYFNPSYVDAMIDSVYRHGPYIVIAPEIAIAHARPNGNVNKVGLSLLKLHRHI 87
Cdd:PRK09854   9 ESSISVIHSAKDWQEAIDFSMVSLLDKNYISENYIQAIKDSTINNGPYYILAPGVAMPHARPECGALKTGMSLTLLEQGV 88
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 517999043  88 DFGEKSHYASLIFVFSAVDTHSHLDILQSLARILGDVTTVNRLMQSQNAAEIVSII 143
Cdd:PRK09854  89 YFPGNDEPIKLLIGLSAADADSHIGAIQALSELLCEEEILEQLLTASSEKQLADII 144
PRK10372 PRK10372
PTS ascorbate transporter subunit IIA;
4-144 2.53e-22

PTS ascorbate transporter subunit IIA;


Pssm-ID: 182417 [Multi-domain]  Cd Length: 154  Bit Score: 86.57  E-value: 2.53e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517999043   4 EMLTEDK-INVKEYVATWEEAIKVAAQPLLDQAYFNPSYVDAMIDSVYRHGPYIVIAPEIAIAHARPNGNVNKVGLSLLK 82
Cdd:PRK10372   5 DSLAENKsIRLQAEAETWQEAVKIGVDLLVAADVVEPRYYQAILDGVEQFGPYFVIAPGLAMPHGRPEEGVKKTGFALVT 84
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 517999043  83 LHRHIDFG-EKSHYASLIFVFSAVDTHSHLDI-LQSLARILGDVTTVNRLMQSQNAAEIVSIIK 144
Cdd:PRK10372  85 LKKPLEFNhEDNDPVDILITMAAVDANTHQEVgIMQIVNLFEDEANFDRLRACRTEQEVLDLID 148
MtlA2 COG4668
Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and ...
4-147 9.00e-22

Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and metabolism];


Pssm-ID: 443705 [Multi-domain]  Cd Length: 143  Bit Score: 84.83  E-value: 9.00e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517999043   4 EMLTEDKINVKEYVATWEEAIKVAAQPLLDQAYFNPSYVDAMIDSVYRHGPYivIAPEIAIAHARPNG--NVNKVGLSLL 81
Cdd:COG4668    2 LILTKENIRLNASAANKEEAIRLAGQLLVEAGYVEPEYIDAMLEREAQVSTY--LGNGIAIPHGTNEAkdLVLKTGISVL 79
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 517999043  82 KLHRHIDFGEkSHYASLIFVFSAVDTHsHLDILQSLARILGDVTTVNRLMQSQNAAEIVSIIKGVE 147
Cdd:COG4668   80 QFPDGVDWGD-GNTVYLVIGIAAKSDE-HLEILRQLARVLSDEENVEKLAKATDAEEILALLTGEN 143
PRK11109 PRK11109
fused PTS fructose transporter subunit IIA/HPr protein;
6-148 1.09e-06

fused PTS fructose transporter subunit IIA/HPr protein;


Pssm-ID: 236849 [Multi-domain]  Cd Length: 375  Bit Score: 46.48  E-value: 1.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517999043   6 LTEDKINVKEYVATWEEAIKVAAQPLLDQAYFNPSYVDAMIDSVYRHGPYIviAPEIAIAHARPN--GNVNKVGLSLLKL 83
Cdd:PRK11109   4 LSVQDIHLGQQAGNKEEAIRQVAAALTQAGNVAEGYVDGMLAREQQTSTFL--GNGIAIPHGTTDtrDLVLKTGVQVFQF 81
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 517999043  84 HRHIDFGEkshyASLIFVFSAVDTHS--HLDILQSLARILGDVTTVNRLMQSQNAAEIVSIIKGVEQ 148
Cdd:PRK11109  82 PQGVTWGD----GQTAYVAIGIAAKSdeHLGLLRQLTHVLSDDSVAEQLKSATTAEELRALLMGEKQ 144
PRK15083 PRK15083
PTS system mannitol-specific transporter subunit IICBA; Provisional
6-145 3.63e-05

PTS system mannitol-specific transporter subunit IICBA; Provisional


Pssm-ID: 237905 [Multi-domain]  Cd Length: 639  Bit Score: 42.35  E-value: 3.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517999043   6 LTEDKINVKEYVATWEEAIKVAAQPLLDQAYFNPSYVDAMID-----SVYrhgpyivIAPEIAIAH--ARPNGNVNKVGL 78
Cdd:PRK15083 497 LGAENIFLGLKAATKEEAIRFAGEQLVKGGYVEPEYVDAMLDrekltSTY-------LGESIAVPHgtVEAKDRVLKTGV 569
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 517999043  79 SLLKLHRHIDFGEKSHYASLIFVFSAVDTHSHLDILQSLARILGDVTTVNRLMQSQNAAEIVSIIKG 145
Cdd:PRK15083 570 VFCQYPEGVRFGEEEDDIARLVIGIAARNNEHIQVITSLTNALDDESVIERLAHTTSVDEVLELLAG 636
PRK09765 PRK09765
PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional
1-143 5.11e-05

PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional


Pssm-ID: 182066 [Multi-domain]  Cd Length: 631  Bit Score: 42.03  E-value: 5.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517999043   1 MSLEMLT-EDKINVKEYVATWEEAIKVAAQPLLDQAYFNPSyvDAMIDSVYRH---GPyIVIAPEIAIAHARpNGNVNKV 76
Cdd:PRK09765   1 MNLTTLThRDLLCLNARFTSREEAIHALAQRLAALGKISST--EQFLEEVYRReslGP-TALGEGLAVPHGK-TAAVKEA 76
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 517999043  77 GLSLLKLHRHIDFG--EKSHYASLIFVFSAVDTHS---HLDILQSLARILGDVTTVNRLMQSQNAAEIVSII 143
Cdd:PRK09765  77 AFAVATLSEPLQWEgvDGPEAVDLIFLLAIPPNEAgttHMQLLTALTTRLADDEIRARIQSATTPDELLSAL 148
PRK13779 PRK13779
bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional
6-145 5.94e-05

bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional


Pssm-ID: 237502 [Multi-domain]  Cd Length: 503  Bit Score: 41.78  E-value: 5.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517999043   6 LTEDKINVKEYVATWEEAIKVAAQPLLDQAYFNPSYVDAMIDSVYRHGPYIviAPEIAIAHA--RPNGNVNKVGLSLLKL 83
Cdd:PRK13779   4 LSESNIHLNAQAINKQQAIEMAAAALEQAGNVENGYLQGMLARELQTSTFL--GNGIAIPHGtlDTRHMVKNTGVQIFQF 81
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 517999043  84 HRHIDFGEKSHYASLIFVfsAVDTHSHLDILQSLARILGDVTTVNRLMQSQNAAEIVSIIKG 145
Cdd:PRK13779  82 PQGIEWGEGNIAYVVIGI--AARSDEHLSLLRQLTHVLSDEDTAAKLATLTDVKEFRAILMG 141
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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