|
Name |
Accession |
Description |
Interval |
E-value |
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
7-599 |
0e+00 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 938.79 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 7 FQSLHTKLVIVYVLLIIIGMQIIGLYFTNSLEKEMTETFKTNISQNAKQIELGIEKIYADGNDSGNT-QKDIQNLLNEYA 85
Cdd:NF033092 2 FRSIHFKIVLIYVLLILIAMQIIGVYFVRQLETQLLNNFKESINLRANLLSYNLEQELSKEDEDDETlEEDIRTILNDFN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 86 NrNEMIEIRFIDKDQIIIATSKQSNRTIINQKANDSSIQKALSLGQENsDTVLKDYgEGKQRVWIKNMPVVTGDG-LIGD 164
Cdd:NF033092 82 N-NDISEIQVIDAKGTILGTSDPSNQSIVGQKTTDSDVKRALLGGKDN-EKILIDP-EDNNRVYVLATPIKSSNGeVVGA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 165 IYIESNINQVYDQLSNINQIFIVGTGISLIITVILGFFIARTITKPITDMRNQTVEMSKGNYTQRVKIYGNDEIGELALA 244
Cdd:NF033092 159 IYIEASMESVYDQMNNINLIFATGTLIALVITAVLGILLARTITRPIKEMRKQALAMAKGDFSRKVKVYGNDEIGQLAEA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 245 FNNLSKRVQEAQANTESEKRRLDSVITHMSDGVIATDRRGRVRIINDMALKMLGKSKEEVSGHFIFEVLDLQDEFSLEEL 324
Cdd:NF033092 239 FNNLTKRLQEAQATTESERRKLDSVLSHMTDGVIATDRRGRVILINDPALEMLNVSRETVLGQSILDVLGLEEEYTLRDL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 325 NENNDSVLIDIN-EEEGIIARVNFSTIVQDTGFVTGYIAVLHDVTEQQQIERERREFVANVSHELRTPLTSMNSYIEALE 403
Cdd:NF033092 319 LEEQDSLLLDFStEEEPLILRANFSVIQRESGFINGLIAVLHDVTEQEKIEQERREFVANVSHELRTPLTTMRSYLEALA 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 404 EGAWRDESIAPQFLSVTREETERMIRLVNDLLHLSKMDNETETITKEIVDFNMFINKIINRHEMTAK--DTTFVRDIPRE 481
Cdd:NF033092 399 DGAWKDPELAPRFLGVTQNETERMIRLVNDLLQLSRMDSKDYKLNKEWVNFNEFFNYIIDRFEMILKnkNITFKREFPKR 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 482 TIFTEVDPDKMTQVFDNVITNAMKYSRGEKRVEFHVKHNpvHSRLTIRIKDNGIGIPINKVDKIFDRFFRVDKARTRKMG 561
Cdd:NF033092 479 DLWVEIDTDKITQVLDNIISNAIKYSPEGGTITFRLLET--HNRIIISISDQGLGIPKKDLDKIFDRFYRVDKARSRKMG 556
|
570 580 590
....*....|....*....|....*....|....*...
gi 517997229 562 GTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFITLPC 599
Cdd:NF033092 557 GTGLGLAIAKEVVEAHGGRIWAESEEGKGTTIYFTLPY 594
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
238-601 |
9.23e-97 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 301.47 E-value: 9.23e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 238 IGELALAFNNLSKRVQEAQANTESEKRRLDSVITHMSDGVIATDRRGRVRIINDMALKMLGKSKEEVSGHFIFEVLDLQD 317
Cdd:COG5002 28 LLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 318 EFSLEELNENNdsVLIDINEEEGIIARVNFSTIVQDTGFVTGYIAVLHDVTEQQQIERERREFVANVSHELRTPLTSMNS 397
Cdd:COG5002 108 LALLILLAALL--LLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRG 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 398 YIEALEEGAWRDESIAPQFLSVTREETERMIRLVNDLLHLSKMDNETETITKEIVDFNMFINKIINRHEMTA--KDTTFV 475
Cdd:COG5002 186 YLELLLDGAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAeeKGIELE 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 476 RDIPRETIFTEVDPDKMTQVFDNVITNAMKYSRGEKRVEFHVKHNPvhSRLTIRIKDNGIGIPINKVDKIFDRFFRVDKA 555
Cdd:COG5002 266 LDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREED--DQVRISVRDTGIGIPEEDLPRIFERFYRVDKS 343
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 517997229 556 RTRKMGGTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFITLPCEK 601
Cdd:COG5002 344 RSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLAR 389
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
184-598 |
5.79e-94 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 294.95 E-value: 5.79e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 184 IFIVGTGISLIITVILGFFIARTITKPITDMRNQTVEMSKGNYTQRVKIYGNDEIGELALAFNNLSKRVQEAQANTESEK 263
Cdd:COG5000 10 LLLLIALLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKEQREELEERR 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 264 RRLDSVITHMSDGVIATDRRGRVRIINDMALKMLGKSKEEVSGHFIFEVLDLQDEFS-LEELNENNDSVLIDINEEEGII 342
Cdd:COG5000 90 RYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGKPLEELLPELDLAElLREALERGWQEEIELTRDGRRT 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 343 ARVNFSTIVQDtgfvtGYIAVLHDVTEQQQIERER--REFVANVSHELRTPLTSMNSYIEALEE----GAWRDESIAPQF 416
Cdd:COG5000 170 LLVRASPLRDD-----GYVIVFDDITELLRAERLAawGELARRIAHEIKNPLTPIQLSAERLRRkladKLEEDREDLERA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 417 LSVTREETERMIRLVNDLLHLSKMdnetETITKEIVDFNMFINKIIN--RHEMTAKDTTFVRDIPRETIFTEVDPDKMTQ 494
Cdd:COG5000 245 LDTIIRQVDRLKRIVDEFLDFARL----PEPQLEPVDLNELLREVLAlyEPALKEKDIRLELDLDPDLPEVLADRDQLEQ 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 495 VFDNVITNAMKYSRGEKRVEFHVKHNPvhSRLTIRIKDNGIGIPINKVDKIFDRFFrvdkarTRKMGGTGLGLAISKEIV 574
Cdd:COG5000 321 VLINLLKNAIEAIEEGGEIEVSTRRED--GRVRIEVSDNGPGIPEEVLERIFEPFF------TTKPKGTGLGLAIVKKIV 392
|
410 420
....*....|....*....|....
gi 517997229 575 EAHNGRIWANSVEGQGTSIFITLP 598
Cdd:COG5000 393 EEHGGTIELESRPGGGTTFTIRLP 416
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
369-601 |
1.93e-73 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 235.19 E-value: 1.93e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 369 EQQQIERERREFVANVSHELRTPLTSMNSYIEALEEGAWRDESIAPQFLSVTREETERMIRLVNDLLHLSKMDNETETIT 448
Cdd:COG2205 8 ELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLESGKLSLE 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 449 KEIVDFNMFINKIINRHEMTA--KDTTFVRDIPRETIFTEVDPDKMTQVFDNVITNAMKYSRGEKRVEFHVKHNPvhSRL 526
Cdd:COG2205 88 LEPVDLAELLEEAVEELRPLAeeKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREG--DGV 165
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 517997229 527 TIRIKDNGIGIPINKVDKIFDRFFRVDkaRTRKMGGTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFITLPCEK 601
Cdd:COG2205 166 RISVSDNGPGIPEEELERIFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAE 238
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
260-591 |
1.66e-66 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 220.16 E-value: 1.66e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 260 ESEKRRLDSVITHMSDGVIATDRRGRVRIINDMALKMLGKSKEEVSGHFIFEVLDlQDEFsLEELNENNDS-VLID---I 335
Cdd:TIGR02966 2 SALLSRFRAAAQALPDAVVVLDEEGQIEWCNPAAERLLGLRWPDDLGQRITNLIR-HPEF-VEYLAAGRFSePLELpspI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 336 NEEEGIIARVNFSTIVQdtgfvtgYIAVLHDVTEQQQIERERREFVANVSHELRTPLTSMNSYIEALEEGAWRDESIAPQ 415
Cdd:TIGR02966 80 NSERVLEIRIAPYGEEQ-------KLLVARDVTRLRRLEQMRRDFVANVSHELRTPLTVLRGYLETLADGPDEDPEEWNR 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 416 FLSVTREETERMIRLVNDLLHLSKMDNETETITKEIVDFNMFINKIinRHEMTAKDTtfVRDIpreTIFTEVDP------ 489
Cdd:TIGR02966 153 ALEIMLEQSQRMQSLVEDLLTLSRLESAASPLEDEPVDMPALLDHL--RDEAEALSQ--GKNH---QITFEIDGgvdvlg 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 490 --DKMTQVFDNVITNAMKYSRGEKRVEFHVKHNPVHSRLTirIKDNGIGIPINKVDKIFDRFFRVDKARTRKMGGTGLGL 567
Cdd:TIGR02966 226 deDELRSAFSNLVSNAIKYTPEGGTITVRWRRDGGGAEFS--VTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGL 303
|
330 340
....*....|....*....|....
gi 517997229 568 AISKEIVEAHNGRIWANSVEGQGT 591
Cdd:TIGR02966 304 AIVKHVLSRHHARLEIESELGKGS 327
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
371-598 |
1.19e-65 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 217.85 E-value: 1.19e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 371 QQIERERREFVANVSHELRTPLTSMNSYIEALEEGAwrDESIApQFLSVTREETERMIRLVNDLLHLSKMDNETETITKE 450
Cdd:COG0642 104 EEANEAKSRFLANVSHELRTPLTAIRGYLELLLEEL--DEEQR-EYLETILRSADRLLRLINDLLDLSRLEAGKLELEPE 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 451 IVDFNMFINKIINRHEMTA--KDTTFVRDIPRETIFTEVDPDKMTQVFDNVITNAMKYSRGEKRVEFHVKHNpvHSRLTI 528
Cdd:COG0642 181 PVDLAELLEEVVELFRPLAeeKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRRE--GDRVRI 258
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 529 RIKDNGIGIPINKVDKIFDRFFRVDKARTRkmGGTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFITLP 598
Cdd:COG0642 259 SVEDTGPGIPPEDLERIFEPFFRTDPSRRG--GGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLP 326
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
260-604 |
3.22e-59 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 202.00 E-value: 3.22e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 260 ESEKRRLDSVITHMSDGVIATDRRGRVRIINDMALKMLGKSKEEVSGHFIFEVLDLQDEFS--LEELNENNDSVL---ID 334
Cdd:COG3852 3 RESEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFPEDSPLRelLERALAEGQPVTereVT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 335 INEEEGIIARVNFS-TIVQDTGFVTGYIAVLHDVTEQQQIERERR---------EFVANVSHELRTPLTSMNSYIEALEE 404
Cdd:COG3852 83 LRRKDGEERPVDVSvSPLRDAEGEGGVLLVLRDITERKRLERELRraeklaavgELAAGLAHEIRNPLTGIRGAAQLLER 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 405 GAwrDESIAPQFLSVTREETERMIRLVNDLLHLSKmdneTETITKEIVDFNMFINKIIN--RHEMtAKDTTFVRDIPRET 482
Cdd:COG3852 163 EL--PDDELREYTQLIIEEADRLNNLVDRLLSFSR----PRPPEREPVNLHEVLERVLEllRAEA-PKNIRIVRDYDPSL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 483 IFTEVDPDKMTQVFDNVITN---AMKYS-----RGEKRVEFHVKHNPVHSRLTIRIKDNGIGIPINKVDKIFDRFFrvdk 554
Cdd:COG3852 236 PEVLGDPDQLIQVLLNLVRNaaeAMPEGgtitiRTRVERQVTLGGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFF---- 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 517997229 555 arTRKMGGTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFITLPCEKIEE 604
Cdd:COG3852 312 --TTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQAEE 359
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
154-603 |
9.24e-59 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 207.13 E-value: 9.24e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 154 PVVTGDGLIGDIYIESNINQVYDQLSNINQIFIVGTGISLIITVILGFFIARTITKPItdmrnqtvemskGNYTQRVKIY 233
Cdd:PRK11360 161 PIERNGEVIGYIWANELTEDIRRQAWKMDRRIYAVLAAGLVIGLLLIFLLSRRFSANV------------DIIKDGLSTL 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 234 GND----------EIGELALAFNNLSKRVQEAQANTESekrrldsVITHMSDGVIATDRRGRVRIINDMALKMLGKSKEE 303
Cdd:PRK11360 229 ENDlstrlpplpgELGEISQAINNLAQALRETRSLNEL-------ILESIADGVIAIDRQGKITTMNPAAEVITGLQRHE 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 304 VSGHFIFEVLDLQDEFS------LEELNENNDSVLIDINEEEGIIARVNFSTIVQDTGFVTGYIAVLHDVTEQQQIERER 377
Cdd:PRK11360 302 LVGKPYSELFPPNTPFAsplldtLEHGTEHVDLEISFPGRDRTIELSVSTSLLHNTHGEMIGALVIFSDLTERKRLQRRV 381
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 378 R---------EFVANVSHELRTPLTSMNSYIEALEEGAWRDESiaPQFLSVTREETERMIRLVNDLLHLSKmdneTETIT 448
Cdd:PRK11360 382 ArqerlaalgELVAGVAHEIRNPLTAIRGYVQIWRQQTSDPPS--QEYLSVVLREVDRLNKVIDQLLEFSR----PRESQ 455
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 449 KEIVDFNMFINKIIN--RHEMTAKDTTFVRDIPRETIFTEVDPDKMTQVFDNVITNAM--KYSRGEKRVEfhvKHNPVHS 524
Cdd:PRK11360 456 WQPVSLNALVEEVLQlfQTAGVQARVDFETELDNELPPIWADPELLKQVLLNILINAVqaISARGKIRIR---TWQYSDG 532
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 517997229 525 RLTIRIKDNGIGIPINKVDKIFDRFFrvdkarTRKMGGTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFITLPCEKIE 603
Cdd:PRK11360 533 QVAVSIEDNGCGIDPELLKKIFDPFF------TTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINPQG 605
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
147-598 |
1.43e-47 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 174.20 E-value: 1.43e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 147 RVWIKNMPVVTGDGLIGDIYIESNINQVYDQLSNINQIFIVGTGISLIITVILGFFIARTITKPITDMRNQTVEMSKGNY 226
Cdd:COG4251 42 VLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLL 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 227 TQRVKI--YGNDEIGELALAFNNLSKRVQEAQANTESEKRRLDSVITHMSDGVIATDRRGRVRIINDMALKMLGKSKEEV 304
Cdd:COG4251 122 LLALLLllLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLL 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 305 SGHFIFEVLDLQDEFSLEELNENNDSVLIDINEEEGIIARVNFSTIVQDTGFVTGYIAVLHDVTEQ-----QQIER---E 376
Cdd:COG4251 202 LLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEEleertAELERsneE 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 377 RREFVANVSHELRTPLTSMNSYIEALEEG-AWRDESIAPQFLSVTREETERMIRLVNDLLHLSKMDneTETITKEIVDFN 455
Cdd:COG4251 282 LEQFAYVASHDLREPLRKISGFSQLLEEDyGDKLDEEGREYLERIRDAAERMQALIDDLLAYSRVG--RQELEFEPVDLN 359
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 456 MFINKIINRHEMTAKDTTF---VRDIPreTIftEVDPDKMTQVFDNVITNAMKYSRGEKRVEFHVKHNPVHSRLTIRIKD 532
Cdd:COG4251 360 ELLEEVLEDLEPRIEERGAeieVGPLP--TV--RGDPTLLRQVFQNLISNAIKYSRPGEPPRIEIGAEREGGEWVFSVRD 435
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 517997229 533 NGIGIPINKVDKIFDRFFRVDkaRTRKMGGTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFITLP 598
Cdd:COG4251 436 NGIGIDPEYAEKIFEIFQRLH--SRDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLP 499
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
235-598 |
4.86e-43 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 161.30 E-value: 4.86e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 235 NDEIGELALAFNNLSKRVQEAQANTESEKRrLDSVITHMSDGVIATDRRGRVRIINDMALKMLGKSKEEVSGHFIFEVLD 314
Cdd:COG5809 113 NGDIEGMLAISRDITERKRMEEALRESEEK-FRLIFNHSPDGIIVTDLDGRIIYANPAACKLLGISIEELIGKSILELIH 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 315 LQDEFSLEELN---------ENNDSVLIDINEEEgIIARVNFSTIVQDtGFVTGYIAVLHDVTEQQQIERERR------- 378
Cdd:COG5809 192 SDDQENVAAFIsqllkdggiAQGEVRFWTKDGRW-RLLEASGAPIKKN-GEVDGIVIIFRDITERKKLEELLRkseklsv 269
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 379 --EFVANVSHELRTPLTSMNSYIEALEEGAWRDESiapQFLSVTREETERMIRLVNDLLHLSKmdneTETITKEIVDFNM 456
Cdd:COG5809 270 vgELAAGIAHEIRNPLTSLKGFIQLLKDTIDEEQK---TYLDIMLSELDRIESIISEFLVLAK----PQAIKYEPKDLNT 342
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 457 FINKIINRHEMTA--KDTTFVRDIPRETIFTEVDPDKMTQVFDNVITNAMKYSrgEKRVEFHVKHNPV-HSRLTIRIKDN 533
Cdd:COG5809 343 LIEEVIPLLQPQAllKNVQIELELEDDIPDILGDENQLKQVFINLLKNAIEAM--PEGGNITIETKAEdDDKVVISVTDE 420
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 517997229 534 GIGIPINKVDKIFDRFFrvdkarTRKMGGTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFITLP 598
Cdd:COG5809 421 GCGIPEERLKKLGEPFY------TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLP 479
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
238-598 |
1.01e-42 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 157.25 E-value: 1.01e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 238 IGELALAFNNLSKRVQEAQANTESEKRrLDSVITHMSDGVIATDRRGRVRIINDMALKMLGKSKEEVSGHFIFEVLDLQD 317
Cdd:COG5807 2 IKQRATDFYHIEEKNQEFKLTEDSEFK-FKQLFDSILEFVFFIDSKGEILECNDFAEDLYGLSQNEYIGKTFVEEKCILK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 318 EFSLEElNENNDSVLIDINEEEGIIARVNFSTIVQDTGFvTGYIAVLHDVT-----EQQQIERER----REFVANVSHEL 388
Cdd:COG5807 81 DEQLYN-KEAFDRIEISYLTKNGEFDEIIYPIYYKDGVI-LGLITVYRDITkrkeaEDKLLRSEKlsvaGELAAGIAHEI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 389 RTPLTSMNSYIEALEEGawRDESIAPQFLSVTREETERMIRLVNDLLHLSKmdneTETITKEIVDFNMFINKIIN--RHE 466
Cdd:COG5807 159 RNPLTSIKGFLQLLQES--REDSEREEYFNIIISEIDRINTIITELLVLSK----PKKFNFKKLNLNDVLEDVIAllSTE 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 467 MTAKDTTFVRDIPRETIFTEVDPDKMTQVFDNVITNAMKYSRGEKRVEFHVKHNPVHSRLTIriKDNGIGIPINKVDKIF 546
Cdd:COG5807 233 AILKNISIKYDLADDEPVINGDKNQLKQVFINLIKNAIEAMETGGNITIKTYVEGDFVVISV--KDEGIGIPEEVLEKIG 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 517997229 547 DRFFrvdkarTRKMGGTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFITLP 598
Cdd:COG5807 311 EPFF------TTKEEGTGLGLSICKKIIEEHNGTIEVESKPGKGTTFTIYLP 356
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
338-598 |
1.49e-42 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 156.88 E-value: 1.49e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 338 EEGIIARVNFSTIVQDTGFVTGYIAVLHDVTEQQQIERERR----------------EFVANVSHELRTPLTSMNSYIEA 401
Cdd:COG4191 87 LLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRelqeqlvqseklaalgELAAGIAHEINNPLAAILGNAEL 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 402 LEE--GAWRDESIAPQFLSVTREETERMIRLVNDLLHLSKMDNETetitKEIVDFNMFINKIIN--RHEMTAKDTTFVRD 477
Cdd:COG4191 167 LRRrlEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRDEEE----REPVDLNELIDEALEllRPRLKARGIEVELD 242
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 478 IPRETIFTEVDPDKMTQVFDNVITN---AMKySRGEKRVEFHVKhnPVHSRLTIRIKDNGIGIPINKVDKIFDRFFRvdk 554
Cdd:COG4191 243 LPPDLPPVLGDPGQLEQVLLNLLINaidAME-EGEGGRITISTR--REGDYVVISVRDNGPGIPPEVLERIFEPFFT--- 316
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 517997229 555 arTRKMG-GTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFITLP 598
Cdd:COG4191 317 --TKPVGkGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLP 359
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
360-598 |
3.27e-42 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 157.48 E-value: 3.27e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 360 YIAVLHDVTEQQQIERERREFVANVSHELRTPLTSMNSYIEALEE----GAWRDESiapqfLSVTREETERMIRLVNDLL 435
Cdd:PRK11006 187 LLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQDqpleGALREKA-----LHTMREQTQRMEGLVKQLL 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 436 HLSKMDNETETITKEIVDFNMFInKIINRHEMTAKDTtfvrdipRETIFTEVDP--------DKMTQVFDNVITNAMKYS 507
Cdd:PRK11006 262 TLSKIEAAPTIDLNEKVDVPMML-RVLEREAQTLSQG-------KHTITFEVDNslkvfgneDQLRSAISNLVYNAVNHT 333
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 508 RGEKRVEFHVKHNPVHSRLTIriKDNGIGIPINKVDKIFDRFFRVDKARTRKMGGTGLGLAISKEIVEAHNGRIWANSVE 587
Cdd:PRK11006 334 PEGTHITVRWQRVPQGAEFSV--EDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEV 411
|
250
....*....|.
gi 517997229 588 GQGTSIFITLP 598
Cdd:PRK11006 412 GKGTRFSFVLP 422
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
374-606 |
1.45e-38 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 148.24 E-value: 1.45e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 374 ERERREFVANVSHELRTPLTSMNSYIEALEEGAWRdesIAPQFLSVTREETERMIRLVNDLLHLSKMDNETETITKEIVD 453
Cdd:PRK10549 237 EQMRRDFMADISHELRTPLAVLRGELEAIQDGVRK---FTPESVASLQAEVGTLTKLVDDLHQLSLSDEGALAYRKTPVD 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 454 FNMFINKIIN--RHEMTAKDTTFVRDIPRE-TIFTevDPDKMTQVFDNVITNAMKY--SRGEKRVEFHVKHNpvhsRLTI 528
Cdd:PRK10549 314 LVPLLEVAGGafRERFASRGLTLQLSLPDSaTVFG--DPDRLMQLFNNLLENSLRYtdSGGSLHISAEQRDK----TLRL 387
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 517997229 529 RIKDNGIGIPINKVDKIFDRFFRVDKARTRKMGGTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFITLPCEKIEEGD 606
Cdd:PRK10549 388 TFADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERDLQRE 465
|
|
| KinD |
COG5808 |
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ... |
371-598 |
3.17e-38 |
|
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 146.82 E-value: 3.17e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 371 QQIERERRE----FVANVSHELRTPLTSMNSYIEALEEGAwrDESIAPQFLSVTREETERMIRLVNDLLHLSKMdnetET 446
Cdd:COG5808 231 QEINTQKLEligtFAASTAHEIRNPLTSIKGFIQLLQEKY--PELEDQKYFDIIQEEIQRINQIVSEFLVLGKP----TA 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 447 ITKEIVDFNMFINKIIN--RHEMTAKDTTFVRDIPRETIFTEVDPDKMTQVFDNVITNAMKYSRGEKRVEFHVKHNPVHS 524
Cdd:COG5808 305 KKLELDDLNELIEEILSiiDSEANLKNIRVEKQSLDEPLHIKCDKDRIKQVLLNLIKNAIEAMKEGGKLTISIENDDEKA 384
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 517997229 525 rlTIRIKDNGIGIPINKVDKIFDRFFrvdkarTRKMGGTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFITLP 598
Cdd:COG5808 385 --VIEVIDNGEGIPEDIIDEIFEPFV------TTKEGGTGLGLSVCKRIVEMHGGEIDIESEEGKGTTFTIRLP 450
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
232-598 |
1.40e-37 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 146.03 E-value: 1.40e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 232 IYGNDEIGELALAFNNLSKRVQEAqanTESEKRRLDSVITHMSDGVIATDRRGRVRIINDMALKMLGKSKEEVSGHFIFE 311
Cdd:COG5805 128 YNQNGQAAILALRDITKKKKIEEI---LQEQEERLQTLIENSPDLICVIDTDGRILFINESIERLFGAPREELIGKNLLE 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 312 VLDLQD-EFSLEELNENND-----SVLIDINEEEG--IIARVNFSTIVQDTGFVTGYIAVLHDVTEQQQIERERR----- 378
Cdd:COG5805 205 LLHPCDkEEFKERIESITEvwqefIIEREIITKDGriRYFEAVIVPLIDTDGSVKGILVILRDITEKKEAEELMArsekl 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 379 ----EFVANVSHELRTPLTSMNSYIEALEEGAWRDEsiapQFLSVTREETERMIRLVNDLLHLSKMDN---ETETITKEI 451
Cdd:COG5805 285 siagQLAAGIAHEIRNPLTSIKGFLQLLQPGIEDKE----EYFDIMLSELDRIESIISEFLALAKPQAvnkEKENINELI 360
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 452 VDFNMFINkiinrHEMTAKDTTFVRDIPRETIFTEVDPDKMTQVFDNVITNAMKYSRGEKRVEFHVKHNpvHSRLTIRIK 531
Cdd:COG5805 361 QDVVTLLE-----TEAILHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEE--DNSVIIRVI 433
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 517997229 532 DNGIGIPINKVDKIFDRFFrvdkarTRKMGGTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFITLP 598
Cdd:COG5805 434 DEGIGIPEERLKKLGEPFF------TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
370-598 |
1.05e-36 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 143.63 E-value: 1.05e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 370 QQQIER-------ERReFVANVSHELRTPLTSMNSYIEALEEGawRDEsiapqFLSVTR-------EETERMIRLVNDLL 435
Cdd:NF040691 258 QRQIRQleelsrlQQR-FVSDVSHELRTPLTTIRMAADVIHDS--RDD-----FDPATArsaellhTELDRFESLLSDLL 329
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 436 HLSKMDNETETITKEIVDFNMFINKIINRHEMTA--KDTTFVRDIPRETIFTEVDPDKMTQVFDNVITNAMKYSRGeKRV 513
Cdd:NF040691 330 EISRFDAGAAELDVEPVDLRPLVRRVVDALRQLAerAGVELRVDAPGTPVVAEVDPRRVERVLRNLVVNAIEHGEG-KPV 408
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 514 EFHVKHNPvhSRLTIRIKDNGIGIPINKVDKIFDRFFRVDKARTRKMGGTGLGLAISKEIVEAHNGRIWANSVEGQGTSI 593
Cdd:NF040691 409 VVTVAQDD--TAVAVTVRDHGVGLKPGEVALVFDRFWRADPARARTTGGTGLGLAIALEDARLHGGWLEAWGRPGQGSQF 486
|
....*
gi 517997229 594 FITLP 598
Cdd:NF040691 487 RLTLP 491
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
191-598 |
1.63e-35 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 139.19 E-value: 1.63e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 191 ISLIITVILGFFIARTITKPITDMRNQTVEMSKGNYTQRVKIYGNDEIGELALAFNNLSkrvqeaqantesekrrldsvi 270
Cdd:NF012163 172 LALLLAALAAFLLARGLLAPVKRLVEATHRLAAGDYTTRVTPTSNDELGKLAQDFNQLA--------------------- 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 271 thmsdgviatdrrgrvriindmalkmlgkskeevsghfifEVLDlqdefsleelnenndsvlidineeegiiarvnfsti 350
Cdd:NF012163 231 ----------------------------------------STLE------------------------------------ 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 351 vqdtgfvtgyiavlhdvteqqQIERERREFVANVSHELRTPLTSMNSYIEALEEGAWRdesIAPQFLSVTREETERMIRL 430
Cdd:NF012163 235 ---------------------KNEQMRRDFMADISHELRTPLAVLRAELEAIQDGIRK---FTPESLDSLQAEVGTLTKL 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 431 VNDLLHLSKMDNETETITKEIVDFNMFINKIIN--RHEMTAKDTTFVRDIPrETIFTEVDPDKMTQVFDNVITNAMKYSR 508
Cdd:NF012163 291 VDDLHDLSMSDEGALAYQKASVDLVPLLEVEGGafRERFASAGLELEVSLP-DSSLVFGDRDRLMQLFNNLLENSLRYTD 369
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 509 GEKRVEFHVKHNPvhSRLTIRIKDNGIGIPINKVDKIFDRFFRVDKARTRKMGGTGLGLAISKEIVEAHNGRIWANSVEG 588
Cdd:NF012163 370 SGGSLHISASQRP--KEVTLTVADSAPGVSDEQLARLFERFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTLHAAHSPL 447
|
410
....*....|
gi 517997229 589 QGTSIFITLP 598
Cdd:NF012163 448 GGLRIVVTLP 457
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
488-598 |
1.32e-34 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 126.61 E-value: 1.32e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 488 DPDKMTQVFDNVITNAMKYSRGEKRVEFHVKHNPVHsrLTIRIKDNGIGIPINKVDKIFDRFFRVDKaRTRKMGGTGLGL 567
Cdd:smart00387 2 DPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDH--VEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGL 78
|
90 100 110
....*....|....*....|....*....|.
gi 517997229 568 AISKEIVEAHNGRIWANSVEGQGTSIFITLP 598
Cdd:smart00387 79 SIVKKLVELHGGEISVESEPGGGTTFTITLP 109
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
492-597 |
6.70e-34 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 124.64 E-value: 6.70e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 492 MTQVFDNVITNAMKYSRGEKRVEFHVKHNPvhSRLTIRIKDNGIGIPINKVDKIFDRFFRVDKARTRkmGGTGLGLAISK 571
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEG--DGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREG--GGTGLGLAIVR 76
|
90 100
....*....|....*....|....*.
gi 517997229 572 EIVEAHNGRIWANSVEGQGTSIFITL 597
Cdd:cd00075 77 RIVEAHGGRITVESEPGGGTTFTVTL 102
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
370-598 |
1.13e-32 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 129.69 E-value: 1.13e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 370 QQQIERERReFVANVSHELRTPLTSMNSYIEALEEGAWRDESIAP-----QFLSVTREETERMIRLVNDLLHLSKMDNET 444
Cdd:PRK09303 145 LEQLKFKDR-VLAMLAHDLRTPLTAASLALETLELGQIDEDTELKpalieQLQDQARRQLEEIERLITDLLEVGRTRWEA 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 445 ETITKEIVDFNMFINKIINRHE--MTAKDTTFVRDIPRE--TIFteVDPDKMTQVFDNVITNAMKYSRGEKRVEFHVKHn 520
Cdd:PRK09303 224 LRFNPQKLDLGSLCQEVILELEkrWLAKSLEIQTDIPSDlpSVY--ADQERIRQVLLNLLDNAIKYTPEGGTITLSMLH- 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 521 pvhsRLT----IRIKDNGIGIPINKVDKIFDRFFRVDkaRTRKMGGTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFIT 596
Cdd:PRK09303 301 ----RTTqkvqVSICDTGPGIPEEEQERIFEDRVRLP--RDEGTEGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFT 374
|
..
gi 517997229 597 LP 598
Cdd:PRK09303 375 LP 376
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
380-588 |
1.05e-31 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 128.27 E-value: 1.05e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 380 FVANVSHELRTPLTSM--------------NSYIEALEEGAwrdesiapqflsvtrEETERMIRLVNDLLHLSKMDNETE 445
Cdd:TIGR01386 244 FSADLAHELRTPLTNLlgqtqvalsqprtgEEYREVLESNL---------------EELERLSRMVSDMLFLARADNGQL 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 446 TITKEIVDFNMFINKIINRHEMTAKDTTFVRDIpRETIFTEVDPDKMTQVFDNVITNAMKYSRGEKRVEFHVKHNPVHSR 525
Cdd:TIGR01386 309 ALERVRLDLAAELAKVAEYFEPLAEERGVRIRV-EGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVR 387
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 517997229 526 ltIRIKDNGIGIPINKVDKIFDRFFRVDKARTRKMGGTGLGLAISKEIVEAHNGRIWANSVEG 588
Cdd:TIGR01386 388 --VSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDG 448
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
488-598 |
1.94e-31 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 117.85 E-value: 1.94e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 488 DPDKMTQVFDNVITNAMKYSRGEKRVEFHVKHnpvHSRLTIRIKDNGIGIPINKVDKIFDRFFRVDKartRKMGGTGLGL 567
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAGEITVTLSE---GGELTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGL 75
|
90 100 110
....*....|....*....|....*....|.
gi 517997229 568 AISKEIVEAHNGRIWANSVEGQGTSIFITLP 598
Cdd:pfam02518 76 SIVRKLVELLGGTITVESEPGGGTTVTLTLP 106
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
367-598 |
3.39e-30 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 123.89 E-value: 3.39e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 367 VTEQQQIererrefVANVSHELRTPLTSMNsYIEALeegAWRDESIAPQflsVTREETE--RMIRLVNDLLHLSKMDNET 444
Cdd:PRK09470 240 MTSQQRL-------LSDISHELRTPLTRLQ-LATAL---LRRRQGESKE---LERIETEaqRLDSMINDLLVLSRNQQKN 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 445 EtITKEIVDFNMFINKIINRHEMTA----KDTTFVRDIPRETIFTevDPDKMTQVFDNVITNAMKYSRGEKRVEFHVKHN 520
Cdd:PRK09470 306 H-LERETFKANSLWSEVLEDAKFEAeqmgKSLTVSAPPGPWPING--NPNALASALENIVRNALRYSHTKIEVAFSVDKD 382
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 517997229 521 pvhsRLTIRIKDNGIGIPINKVDKIFDRFFRVDKARTRKMGGTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFITLP 598
Cdd:PRK09470 383 ----GLTITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLP 456
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
494-598 |
2.21e-28 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 108.95 E-value: 2.21e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 494 QVFDNVITNAMKYSRGEKRVEFHVKHNPVHsrltIRIKDNGIGIPINKVDKIFDRFFRVDKARTRKMGGTGLGLAISKEI 573
Cdd:cd16949 3 RALENVLRNALRYSPSKILLDISQDGDQWT----ITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERA 78
|
90 100
....*....|....*....|....*
gi 517997229 574 VEAHNGRIWANSVEGQGTSIFITLP 598
Cdd:cd16949 79 IEQHGGKIKASNRKPGGLRVRIWLP 103
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
191-601 |
2.26e-28 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 117.26 E-value: 2.26e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 191 ISLIITVILGFFIARTITKPITDMRNQTVEMSKGNYTQRVKIYGNDEIGELALAFNNLSKRVQEAQANTESEKRRL---- 266
Cdd:COG3290 7 LLLLLLILLILILILLLLLLIILLLILLLVLLLLLFLLFVIILLLLLLILLLILLLLLLLLLAALLLKLLEEIARLveer 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 267 DSVITHMSDGVIATDRRGRVRIINDMALKMLGKskeEVSGHFIFEVLDlqdefslEELNENNDSVLIDINEEEGIIARVn 346
Cdd:COG3290 87 EAVLESIREGVIAVDRDGRITLINDAARRLLGL---DAIGRPIDEVLA-------EVLETGERDEEILLNGRVLVVNRV- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 347 fstIVQDTGFVTGYIAVLHDVTEQQQIERE---RREFVANV---SHELRTPLTSMNSYIEALEEgawrDESIapQFLsvt 420
Cdd:COG3290 156 ---PIRDDGRVVGAVATFRDRTELERLEEElegVKELAEALraqRHDFRNHLHTISGLLQLGEY----DEAL--EYI--- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 421 REETERMIRLVNDLLHLSKmdnetetitkeivdfNMFINKIINR--HEMTAKDTTFVRDIPRETIFTEVDPDKMTQVFDN 498
Cdd:COG3290 224 DEISEELQELIDSLLSRIG---------------NPVLAALLLGkaARARERGIDLTIDIDSDLPDLPLSDTDLVTILGN 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 499 VITNAM----KYSRGEKRVEFHVKHNPvhSRLTIRIKDNGIGIPINKVDKIFDRFFRvdkarTRKMGGTGLGLAISKEIV 574
Cdd:COG3290 289 LLDNAIeaveKLPEEERRVELSIRDDG--DELVIEVEDSGPGIPEELLEKIFERGFS-----TKLGEGRGLGLALVKQIV 361
|
410 420
....*....|....*....|....*..
gi 517997229 575 EAHNGRIWANSVEGQGTSIFITLPCEK 601
Cdd:COG3290 362 EKYGGTIEVESEEGEGTVFTVRLPKEG 388
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
494-599 |
8.12e-28 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 107.58 E-value: 8.12e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 494 QVFDNVITNAMKY-SRGEkrVEFHVK---HNPVHSRLTIRIKDNGIGIPINKVDKIFDRFFRVDKARTRKMGGTGLGLAI 569
Cdd:cd16922 3 QILLNLLGNAIKFtEEGE--VTLRVSleeEEEDGVQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAI 80
|
90 100 110
....*....|....*....|....*....|
gi 517997229 570 SKEIVEAHNGRIWANSVEGQGTSIFITLPC 599
Cdd:cd16922 81 SKKLVELMGGDISVESEPGQGSTFTFTLPL 110
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
370-606 |
3.47e-27 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 114.88 E-value: 3.47e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 370 QQQIERE--RRE-------FVANVSHELRTPLTSMNSYIEALEEGAwRDESIAPQFLSVTREETERMIRLVNDLLHLSKM 440
Cdd:PRK10364 221 RQLLQDEmkRKEklvalghLAAGVAHEIRNPLSSIKGLAKYFAERA-PAGGEAHQLAQVMAKEADRLNRVVSELLELVKP 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 441 DNetetITKEIVDFNMFINKIINRHEMTAKDTTF-VRDIPRETIFT-EVDPDKMTQVFDNVITNAMKySRGEKRVeFHVK 518
Cdd:PRK10364 300 TH----LALQAVDLNDLINHSLQLVSQDANSREIqLRFTANDTLPEiQADPDRLTQVLLNLYLNAIQ-AIGQHGV-ISVT 373
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 519 HNPVHSRLTIRIKDNGIGIPINKVDKIFDRFFrvdkarTRKMGGTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFITLP 598
Cdd:PRK10364 374 ASESGAGVKISVTDSGKGIAADQLEAIFTPYF------TTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLP 447
|
....*...
gi 517997229 599 cEKIEEGD 606
Cdd:PRK10364 448 -VNITRRD 454
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
372-604 |
9.62e-27 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 115.90 E-value: 9.62e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 372 QIERE--RREFVANVSHELRTPLTSMNSYIEAL-----EEGAwrdeSIAPQfLSVTREETERMIRLVNDLLHLSKMDNET 444
Cdd:PRK10490 657 ASEREqlRNALLAALSHDLRTPLTVLFGQAEILtldlaSEGS----PHARQ-ASEIRQQVLNTTRLVNNLLDMARIQSGG 731
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 445 ETITKEIVDFNMFINKIINRHEMTAKDTTFVRDIPRETIFTEVDPDKMTQVFDNVITNAMKYSrGEKrVEFHVKHNPVHS 524
Cdd:PRK10490 732 FNLRKEWLTLEEVVGSALQMLEPGLSGHPINLSLPEPLTLIHVDGPLFERVLINLLENAVKYA-GAQ-AEIGIDAHVEGE 809
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 525 RLTIRIKDNGIGIPINKVDKIFDRFFRVDKARTrkMGGTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFITLPCEKIEE 604
Cdd:PRK10490 810 RLQLDVWDNGPGIPPGQEQLIFDKFARGNKESA--IPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLPLETPPE 887
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
380-598 |
2.07e-26 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 112.94 E-value: 2.07e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 380 FVANVSHELRTPLTSMNSYIE-ALEEGawRDESIAPQFLSVTREETERMIRLVNDLLHLSKMDNETETITKEIVDFNMFI 458
Cdd:PRK09835 265 FSADIAHEIRTPITNLITQTEiALSQS--RSQKELEDVLYSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKMLDLADEV 342
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 459 NKIINRHEMTAKDTTFVRDIPRETIFTEVDPDKMTQVFDNVITNAMKYSRGEKRVEFHVKHNPVHSRLTIriKDNGIGIP 538
Cdd:PRK09835 343 GKVFDFFEAWAEERGVELRFVGDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVV--ENPGTPIA 420
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 539 INKVDKIFDRFFRVDKARTRKMGGTGLGLAISKEIVEAHNGRIWANSvEGQGTSIFITLP 598
Cdd:PRK09835 421 PEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTS-DARGTRFVISLP 479
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
488-598 |
3.42e-26 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 102.93 E-value: 3.42e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 488 DPDKMTQVFDNVITNAMKYSRGEKRVEFHVKHNPVHSRLTIriKDNGIGIPINKVDKIFDRFFRVDKARTRKMGGTGLGL 567
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDV--EDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGL 78
|
90 100 110
....*....|....*....|....*....|.
gi 517997229 568 AISKEIVEAHNGRIWANSVEGQGTSIFITLP 598
Cdd:cd16946 79 AICHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
365-598 |
2.66e-25 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 111.41 E-value: 2.66e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 365 HDVTEQQ--QIERERREFVANVSHELRTPLTSMNSYIEALeegawRDESIAP---QFLSVTREETERMIRLVNDLLHLSK 439
Cdd:TIGR02956 450 HAKARAEaeEANRAKSAFLATMSHEIRTPLNGILGTLELL-----GDTGLTSqqqQYLQVINRSGESLLDILNDILDYSK 524
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 440 MDNETETITKEIVDFNMFINKIIN--RHEMTAKDTTFVRDIPRETIFTEV-DPDKMTQVFDNVITNAMKY-SRGEkrVEF 515
Cdd:TIGR02956 525 IEAGHLSISPRPFDLNALLDDVHHlmVSRAQLKGIQLRLNIPEQLPNWWQgDGPRIRQVLINLVGNAIKFtDRGS--VVL 602
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 516 HVKHNPvHSRLTIRIKDNGIGIPINKVDKIFDRFFRVDKarTRKMGGTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFI 595
Cdd:TIGR02956 603 RVSLND-DSSLLFEVEDTGCGIAEEEQATLFDAFTQADG--RRRSGGTGLGLAISQRLVEAMDGELGVESELGVGSCFWF 679
|
...
gi 517997229 596 TLP 598
Cdd:TIGR02956 680 TLP 682
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
366-609 |
3.41e-23 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 104.64 E-value: 3.41e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 366 DVTEQQQIE-------RERREFVANVSHELRTPLTSMNSYIEALeegawRDESIAPQ---FLSVTREETERMIRLVNDLL 435
Cdd:PRK11091 265 DITERKRYQdalekasRDKTTFISTISHELRTPLNGIVGLSRIL-----LDTELTAEqrkYLKTIHVSAITLGNIFNDII 339
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 436 HLSKMDNETETITKEIVDFNMFINKIINRHEMTAKDTTFVRDIPRET---IFTEVDPDKMTQVFDNVITNAMKYSRgEKR 512
Cdd:PRK11091 340 DMDKMERRKLQLDNQPIDFTDFLADLENLSGLQAEQKGLRFDLEPLLplpHKVITDGTRLRQILWNLISNAVKFTQ-QGG 418
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 513 VEFHVKHNPvHSRLTIRIKDNGIGIPINKVDKIFDRFFRV-DKARTRKMGGTGLGLAISKEIVEAHNGRIWANSVEGQGT 591
Cdd:PRK11091 419 VTVRVRYEE-GDMLTFEVEDSGIGIPEDELDKIFAMYYQVkDSHGGKPATGTGIGLAVSKRLAQAMGGDITVTSEEGKGS 497
|
250
....*....|....*...
gi 517997229 592 SIFITLPCEKIEEGDWDA 609
Cdd:PRK11091 498 CFTLTIHAPAVAEEVEDA 515
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
492-598 |
7.05e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 93.55 E-value: 7.05e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 492 MTQVFDNVITNAMKYSRGEKRVEFHVKHNPVHSRLTIRIKDNGIGIPINKVDKIFDRFFRVDKarTRKMGGTGLGLAISK 571
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHS--REEYEGTGVGLAIVR 78
|
90 100
....*....|....*....|....*..
gi 517997229 572 EIVEAHNGRIWANSVEGQGTSIFITLP 598
Cdd:cd16921 79 KIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
377-598 |
3.53e-22 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 99.68 E-value: 3.53e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 377 RREFVANVSHELRTPLTSMNsYIEALEEGAWRDESIApqflsvtreeTERMI----RLVNDLLHLSKMDNETETITKEIV 452
Cdd:PRK10604 212 KKQLIDGIAHELRTPLVRLR-YRLEMSDNLSAAESQA----------LNRDIgqleALIEELLTYARLDRPQNELHLSEP 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 453 DFNMFINKIINRHEMTAKDTTFVRDIPRETIFTEVDPDKMTQVFDNVITNAMKYSRGekRVEFHVKHNPVHSRLTIriKD 532
Cdd:PRK10604 281 DLPAWLSTHLADIQAVTPEKTVRLDTPHQGDYGALDMRLMERVLDNLLNNALRYAHS--RVRVSLLLDGNQACLIV--ED 356
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 517997229 533 NGIGIPINKVDKIFDRFFRVDKARTRKMGGTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFITLP 598
Cdd:PRK10604 357 DGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWP 422
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
371-598 |
1.41e-21 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 97.67 E-value: 1.41e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 371 QQIERERREFVANVSHELRTPLTSMNSYIEAL-EEGAWRDESIApqflsvtrEETERMIRLVNDLLHLSKMDNETETitk 449
Cdd:PRK09467 223 KQLEDDRTLLMAGVSHDLRTPLTRIRLATEMMsEEDGYLAESIN--------KDIEECNAIIEQFIDYLRTGQEMPM--- 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 450 EIVDfnmfINKIInrHEMTAKDTTFVRDIprETIFTE------VDPDKMTQVFDNVITNAMKYSRGEKRVEFHVKHNpvh 523
Cdd:PRK09467 292 EMAD----LNALL--GEVIAAESGYEREI--ETALQPgpievpMNPIAIKRALANLVVNAARYGNGWIKVSSGTEGK--- 360
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 517997229 524 sRLTIRIKDNGIGIPINKVDKIFDRFFRVDKARTRKmgGTGLGLAISKEIVEAHNGRI-WANSVEGqGTSIFITLP 598
Cdd:PRK09467 361 -RAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARGSS--GTGLGLAIVKRIVDQHNGKVeLGNSEEG-GLSARAWLP 432
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
382-598 |
1.76e-21 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 96.22 E-value: 1.76e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 382 ANVSHELRTPLTSMNSYIEALEEGAWR-DESIAPQFLSvtreETERMIRLVNDLLHLSKMDNETETITKEIVDFNMFINK 460
Cdd:NF012226 143 AAIAHELRTPITILQGRLQGILDGVFEpDPALFKSLLN----QVEGLSHLVEDLRTLSLVENQQLRLNYESVDLKDSIEK 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 461 IINRHE--MTAKDTTFVRDIPRETIFteVDPDKMTQVFDNVITNAMKYSRGEKrveFHVKHNPVHSRLTIRIKDNGIGIP 538
Cdd:NF012226 219 VLKMFEdrLEQAQLTIVLNLTATPVF--CDRRRIEQVLIALIDNAIRYANAGK---LKISSSVIQDDWILQIEDEGPGIA 293
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 517997229 539 INKVDKIFDRFFRVDKARTRKMGGTGLGLAISKEIVEAHNGRI-WANSvegQGTSIF-ITLP 598
Cdd:NF012226 294 EEYQQDLFNPFFRLEQSRNKEFGGTGLGLAVVHAIVIAHKGSIeYSNS---QGNSVFtIKLP 352
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
378-598 |
4.04e-21 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 97.89 E-value: 4.04e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 378 REFVANVSHELRTPLTSMNSYIEALEEGAWRDEsiAPQFLSVTREETERMIRLVNDLLHLSKMDNETETITKEIVDFNMF 457
Cdd:TIGR03785 486 ENMSSRLSHELRTPVAVVRSSLENLELQALEQE--KQKYLERAREGTERLSMILNNMSEATRLEQAIQSAEVEDFDLSEV 563
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 458 INKIINRHEMTAKDTTFVRDIPRETIFTEVDPDKMTQVFDNVITNAMKYSRGEKRVEFHVKHNPVHSRLTIRikDNGIGI 537
Cdd:TIGR03785 564 LSGCMQGYQMTYPPQRFELNIPETPLVMRGSPELIAQMLDKLVDNAREFSPEDGLIEVGLSQNKSHALLTVS--NEGPPL 641
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 517997229 538 PINKVDKIFDRFFRVDKARTRKMGGTGLGLAISKEIVEAHNGRIWA-NSVEGQGTSIFITLP 598
Cdd:TIGR03785 642 PEDMGEQLFDSMVSVRDQGAQDQPHLGLGLYIVRLIADFHQGRIQAeNRQQNDGVVFRISLP 703
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
496-598 |
9.19e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 84.95 E-value: 9.19e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 496 FDNVITNAMKYSRGEKRVEFHVKHNPVHSRLTIriKDNGIGIPINKVDKIFDRFFRVDKARTRKMGGTGLGLAISKEIVE 575
Cdd:cd16952 5 FSNLVSNAVKYTPPSDTITVRWSQEESGARLSV--EDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVMS 82
|
90 100
....*....|....*....|...
gi 517997229 576 AHNGRIWANSVEGQGTSIFITLP 598
Cdd:cd16952 83 RHDARLLIASELGKGSRFTCLFP 105
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
492-598 |
1.52e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 84.04 E-value: 1.52e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 492 MTQVFDNVITNAMKYSRGEkrVEFHVKHNPvhSRLTIRIKDNGIGIPINKVDKIFDRFFRVDKARTrkMGGTGLGLAISK 571
Cdd:cd16950 1 LKRVLSNLVDNALRYGGGW--VEVSSDGEG--NRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQ 74
|
90 100
....*....|....*....|....*..
gi 517997229 572 EIVEAHNGRIWANSVEGQGTSIFITLP 598
Cdd:cd16950 75 RISDAHGGSLTLANRAGGGLCARIELP 101
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
379-599 |
9.15e-19 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 88.77 E-value: 9.15e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 379 EFVANVSHELRTPLTSMNSYIEALEEGAWRDESiAPQFLSVTREETERMIRLVNDLLHLSKMDNEtetiTKEIVDFNMFI 458
Cdd:COG5806 203 ELAASIAHEVRNPLTVVRGFIQLLQEPELSDEK-RKQYIRIALEELDRAEAIITDYLTFAKPQPE----KLEKIDVSEEL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 459 NKIIN-RHEMTAKDTTFVRDIPRETIFTEVDPDKMTQVFDNVITNAMKYSRGEKRVEFHVKHNPVHsrLTIRIKDNGIGI 537
Cdd:COG5806 278 EHVIDvLSPYANMNNVEIQTELEPGLYIEGDRQKLQQCLINIIKNGIEAMPNGGTLTIDVSIDKNK--VIISIKDTGVGM 355
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 517997229 538 PINKVDKIFDRFFrvdkarTRKMGGTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFITLPC 599
Cdd:COG5806 356 TKEQLERLGEPYF------STKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITLPL 411
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
489-598 |
1.11e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 81.70 E-value: 1.11e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 489 PDKMTQVFDNVITNAMKYSRGEKRVEFHVKHNpvHSRLTIRIKDNGIGIPINKVDKIFDRFFRvdkarTRKMG-GTGLGL 567
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQAMEGRGRITIRTWAH--VDQVLIEVEDTGSGIDPEILGRIFDPFFT-----TKPVGeGTGLGL 73
|
90 100 110
....*....|....*....|....*....|.
gi 517997229 568 AISKEIVEAHNGRIWANSVEGQGTSIFITLP 598
Cdd:cd16943 74 SLSYRIIQKHGGTIRVASVPGGGTRFTIILP 104
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
371-598 |
2.21e-18 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 88.36 E-value: 2.21e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 371 QQIERerreFVANVSHELRTPLTSMNSYIEALEEGAwrDESIAPQFLSVTREETERMIRLVNDLLHLSKMDNETETITKE 450
Cdd:PRK11100 254 AYVEQ----YVQTLTHELKSPLAAIRGAAELLQEDP--PPEDRARFTGNILTQSARLQQLIDRLLELARLEQRQELEVLE 327
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 451 IVDFNMFINKIINRHEM--TAKDTTFVRDIPRETIftEVDPDKMTQVFDNVITNAMKYS--RGEKRVEFHVKHNPVHsrl 526
Cdd:PRK11100 328 PVALAALLEELVEAREAqaAAKGITLRLRPDDARV--LGDPFLLRQALGNLLDNAIDFSpeGGTITLSAEVDGEQVA--- 402
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 517997229 527 tIRIKDNGIGIPINKVDKIFDRFF---RVDKARTrkmgGTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFITLP 598
Cdd:PRK11100 403 -LSVEDQGPGIPDYALPRIFERFYslpRPANGRK----STGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLP 472
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
374-606 |
3.25e-18 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 87.77 E-value: 3.25e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 374 ERER----REFVANVSHELRTPLTSMNSYIEALEEGawRDESIApQFLSVTREETERMIRLVNDLLHLSKMDNETETITK 449
Cdd:PRK10815 259 ERERytkyRTTLTDLTHSLKTPLAVLQSTLRSLRSG--KQMSVE-QAEPIMLEQISRISQQIGYYLHRASMRSEHNLLSR 335
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 450 EI------VD-FNMFINKIINRhemtaKDTTFVRDIPRETIFTEVDPDKMtQVFDNVITNAMKYSRgeKRVEFHVKHNpv 522
Cdd:PRK10815 336 ELhsvaplLDnLTSALNKVYQR-----KGVNITLDISPEITFVGEKNDFM-EVMGNVLDNACKYCL--EFVEISARQT-- 405
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 523 HSRLTIRIKDNGIGIPINKVDKIFDRFFRVDKARTrkmgGTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFITLPCEKI 602
Cdd:PRK10815 406 DEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRP----GQGLGLSVAREITEQYEGKISAGDSPLGGARMEVIFGRQHS 481
|
....
gi 517997229 603 EEGD 606
Cdd:PRK10815 482 TPKD 485
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
360-604 |
4.57e-18 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 88.64 E-value: 4.57e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 360 YIAVLHDVTEQQ------QIERER--------REFVANVSHELRTPLTSMNSYIEALE-EGAWRDESIapQFLSVTREET 424
Cdd:PRK09959 681 YICGWQDITETRdlihalEVERNKainatvakSQFLATMSHEIRTPISSIMGFLELLSgSGLSKEQRV--EAISLAYATG 758
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 425 ERMIRLVNDLLHLSKMDNETETITKEIVDFNMFINKIINRHEMTAKDTTFVRDIPR---ETIFTEVDPDKMTQVFDNVIT 501
Cdd:PRK09959 759 QSLLGLIGEILDVDKIESGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALSCSStfpDHYLVKIDPQAFKQVLSNLLS 838
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 502 NAMKYS-RGEKRVEFHVKH-NPVHSRLTIRIKDNGIGIPINKVDKIFDRFFRVDKARTRKmgGTGLGLAISKEIVEAHNG 579
Cdd:PRK09959 839 NALKFTtEGAVKITTSLGHiDDNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQT--GSGLGLMICKELIKNMQG 916
|
250 260
....*....|....*....|....*
gi 517997229 580 RIWANSVEGQGTSIFITLPCEKIEE 604
Cdd:PRK09959 917 DLSLESHPGIGTTFTITIPVEISQQ 941
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
488-598 |
4.82e-18 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 79.84 E-value: 4.82e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 488 DPDKMTQVFDNVITNAMKYSRGEKRVEFHVKHNPVhSRLTIRIKDNGIGIPINKVDKIFDRFFRVDKARTRKMGGTGLGL 567
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFRL-NRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGL 79
|
90 100 110
....*....|....*....|....*....|.
gi 517997229 568 AISKEIVEAHNGRIWANSVEGQGTSIFITLP 598
Cdd:cd16925 80 SIVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
494-598 |
8.63e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 78.98 E-value: 8.63e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 494 QVFDNVITN---AMKYSRGEKRvEFHVKHNPVHSR-LTIRIKDNGIGIPINKVDKIFDRFFrvdkarTRKMGGTGLGLAI 569
Cdd:cd16920 3 QVLINLVRNgieAMSEGGCERR-ELTIRTSPADDRaVTISVKDTGPGIAEEVAGQLFDPFY------TTKSEGLGMGLSI 75
|
90 100
....*....|....*....|....*....
gi 517997229 570 SKEIVEAHNGRIWANSVEGQGTSIFITLP 598
Cdd:cd16920 76 CRSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
492-598 |
9.66e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 79.01 E-value: 9.66e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 492 MTQVFDNVITNAMKYSRGEKRVEFHVKHNpvhsRLTIRIKDNGIGIPINKVDKIFDRFFRVDKARTRKMGGTGLGLAISK 571
Cdd:cd16939 1 MARALDNLLRNALRYAHRTVRIALLVSGG----RLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVH 76
|
90 100
....*....|....*....|....*..
gi 517997229 572 EIVEAHNGRIWANSVEGQGTSIFITLP 598
Cdd:cd16939 77 RVALWHGGHVECDDSELGGACFRLTWP 103
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
374-439 |
1.09e-17 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 77.25 E-value: 1.09e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 517997229 374 ERERREFVANVSHELRTPLTSMNSYIEALEEGAWRDESIApQFLSVTREETERMIRLVNDLLHLSK 439
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQR-EYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
492-598 |
2.91e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 77.43 E-value: 2.91e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 492 MTQVFDNVITNAMKYSRGEKRVefHVKHNPVHSRLTIRIKDNGIGIPINKVDKIFDRFFRVDKARtrKMGGTGLGLAISK 571
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRI--YITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSR--NTEGAGLGLSIAK 76
|
90 100
....*....|....*....|....*..
gi 517997229 572 EIVEAHNGRIWAnSVEGQGTSIFITLP 598
Cdd:cd16923 77 AIIELHGGSASA-EYDDNHDLFKVRLP 102
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
376-443 |
3.20e-17 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 76.10 E-value: 3.20e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 517997229 376 ERREFVANVSHELRTPLTSMNSYIEALEEGAWRDEsiAPQFLSVTREETERMIRLVNDLLHLSKMDNE 443
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEE--QREYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
376-443 |
4.60e-17 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 75.68 E-value: 4.60e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 517997229 376 ERREFVANVSHELRTPLTSMNSYIEALEEGAWRDESiaPQFLSVTREETERMIRLVNDLLHLSKMDNE 443
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQ--REYLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
371-600 |
2.89e-16 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 82.59 E-value: 2.89e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 371 QQIERERREFVANVSHELRTPL------------TSMNS----YIEALEEGAWRDESIapqflsvtreetermirlVNDL 434
Cdd:PRK11107 287 QEAARIKSEFLANMSHELRTPLngvigftrqtlkTPLTPtqrdYLQTIERSANNLLAI------------------INDI 348
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 435 LHLSKMDN---ETETITkeiVDFNMFINKIIN-----RHEmtaKDTTFV----RDIPRETIFtevDPDKMTQVFDNVITN 502
Cdd:PRK11107 349 LDFSKLEAgklVLENIP---FSLRETLDEVVTllahsAHE---KGLELTlnidPDVPDNVIG---DPLRLQQIITNLVGN 419
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 503 AMKYS-RG------EKRvefHVKHNPVHsrLTIRIKDNGIGIPINKVDKIFDRFFRVDKARTRKMGGTGLGLAISKEIVE 575
Cdd:PRK11107 420 AIKFTeSGnidilvELR---ALSNTKVQ--LEVQIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQKLVN 494
|
250 260
....*....|....*....|....*
gi 517997229 576 AHNGRIWANSVEGQGTSIFITLPCE 600
Cdd:PRK11107 495 EMGGDISFHSQPNRGSTFWFHLPLD 519
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
481-597 |
3.08e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 74.75 E-value: 3.08e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 481 ETIFTEVDPDKMTQVFDNVITNAMKYSRGEKRVEFHVKhNPVHSrlTIRIKDNGIGIPINKVDKIFDRFFRVDKartRKM 560
Cdd:cd16940 3 ADIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLS-ADDGA--VIRVEDNGPGIDEEELEALFERFYRSDG---QNY 76
|
90 100 110
....*....|....*....|....*....|....*..
gi 517997229 561 GGTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFITL 597
Cdd:cd16940 77 GGSGLGLSIVKRIVELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
495-598 |
3.82e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 74.63 E-value: 3.82e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 495 VFDNVITNAMKYSRGEKRVEFHVKHNPVHSRLtiRIKDNGIGIPINKVDKIFDRFFRVDKARTRKMgGTGLGLAISKEIV 574
Cdd:cd16948 9 IIGQIVSNALKYSKQGGKIEIYSETNEQGVVL--SIKDFGIGIPEEDLPRVFDKGFTGENGRNFQE-STGMGLYLVKKLC 85
|
90 100
....*....|....*....|....
gi 517997229 575 EAHNGRIWANSVEGQGTSIFITLP 598
Cdd:cd16948 86 DKLGHKIDVESEVGEGTTFTITFP 109
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
357-598 |
4.40e-16 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 82.03 E-value: 4.40e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 357 VTGYIAVLHDVTEQQQIER-----ERRE----FVANVSHELRTPLTSMNSYIEaLEEGAWRDESIAPQFLSVTREETERM 427
Cdd:PRK13837 421 LAHAIERRRLETERDALERrlehaRRLEavgtLASGIAHNFNNILGAILGYAE-MALNKLARHSRAARYIDEIISAGARA 499
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 428 IRLVNDLLHLS-KMDNETETitkeiVDFNMFINKIINRHEM-TAKDTTFVRDIPRETIFTEVDPDKMTQVFDNVITNAMK 505
Cdd:PRK13837 500 RLIIDQILAFGrKGERNTKP-----FDLSELVTEIAPLLRVsLPPGVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQ 574
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 506 YSRGEKRVEFHVK--HNPVHSRLT-----------IRIKDNGIGIPINKVDKIFDRFFrvdkarTRKMGGTGLGLAISKE 572
Cdd:PRK13837 575 AMDGAGRVDISLSraKLRAPKVLShgvlppgryvlLRVSDTGAGIDEAVLPHIFEPFF------TTRAGGTGLGLATVHG 648
|
250 260
....*....|....*....|....*.
gi 517997229 573 IVEAHNGRIWANSVEGQGTSIFITLP 598
Cdd:PRK13837 649 IVSAHAGYIDVQSTVGRGTRFDVYLP 674
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
14-604 |
9.26e-16 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 80.34 E-value: 9.26e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 14 LVIVYVLLI---IIGMQIiglyftnsleKEMTETfktNISQNAKQIE--LGIEKIYADGNDSGNTQKDIQNLLNEYANRN 88
Cdd:PRK11086 26 AVVFSVLLVvhlLYFSQI----------SRMTRD---GLAEKALAIArtVADSPIVIQGLQGKPDESGIQTYAEAVRKRN 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 89 EMIEIRFIDKDQIiiatsKQS--NRTIINQKANDSSIQKALsLGQENSDTVLKDYGEGkQRVWIknmPVVTGDG-LIGDI 165
Cdd:PRK11086 93 DLLFIVVTDMQGI-----RYShpNPQKIGKHFIGGDELPAL-KGKENVSINRGTLGQA-LRVFT---PVYDENGkQIGVV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 166 YIESNINQVYDQLSNINQIFIVGTGISLIITVILGFFIARTItKPItdmrnqtvemskgnytqrvkIYG--NDEIgelal 243
Cdd:PRK11086 163 AVGISLSEVTEQINESRWSIYWSILFGALVGLIGTVILVRVL-KRI--------------------LFGlePYEI----- 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 244 afnnlSKRVQEAQANTESEKrrldsvithmsDGVIATDRRGRVRIINDMALKMLGKSK------EEVSGHFIFEVLDLQD 317
Cdd:PRK11086 217 -----STLFEQRQAMLQSIK-----------EGVIAVDDRGEVTLINDEAKRLFNYKKgleddpLGTDVESWMPVSRLKE 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 318 --EFSLEELNENndsvlIDINEEEGIIARVNfstiVQDTGFVTGYIAVLHDVTE-QQQIERerrefvanvshelrtpLTS 394
Cdd:PRK11086 281 vlRTGTPRRDEE-----ININGRLLLTNTVP----VRVNGEIIGAIATFRDKTEvRQLAQR----------------LDG 335
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 395 MNSYIEALeegawrdesiapqflsvtREET-ERMIRL--VNDLLHLSKMDnETETITKEIV-----DFNMFINKI----- 461
Cdd:PRK11086 336 MVNYADAL------------------RAQShEFMNKLhvILGLLHLKSYD-QLEDYILKTAnnyqeEIGSLLGKIkspvi 396
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 462 -------INR-----HEMTAKDTTFVRDIPRETIFTEvdpdkMTQVFDNVITNAM----KYSRGEKRVEFHVKHNpvhsR 525
Cdd:PRK11086 397 agfllgkISRarelgITLIISEDSQLPDSGDEDQVHE-----LITILGNLIENALeavgGEEGGEISVSLHYRNG----W 467
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 517997229 526 LTIRIKDNGIGIPINKVDKIFDRFFrvdkarTRKMGGTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFITLPCEKIEE 604
Cdd:PRK11086 468 LHCEVSDDGPGIAPDEIDAIFDKGY------STKGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIPWDGERS 540
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
477-597 |
2.46e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 72.55 E-value: 2.46e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 477 DIPRETIFTEVDPDKMTQVFDNVITNAMKYSRGEKRVEFHVKHNPVHsrLTIRIKDNGIGIPINKVDKIFDRFFRVDKAR 556
Cdd:cd16947 6 NIPDRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKH--VYIDIWDKGKGISETEKDHVFERLYTLEDSR 83
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 517997229 557 TRKMGGTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFITL 597
Cdd:cd16947 84 NSAKQGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
371-604 |
3.14e-15 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 79.30 E-value: 3.14e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 371 QQIERERR---EFVANVSHELRTPLTSMNSYIEALEEGAWRDESIapQFLSVTREETERMIRLVNDLLHLSKMDNETETI 447
Cdd:PRK15347 389 QRAEQANKrksEHLTTISHEIRTPLNGVLGALELLQNTPLTAEQM--DLADTARQCTLSLLAIINNLLDFSRIESGQMTL 466
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 448 TKE------IVDFNMF------INKIINRHemtakdtTFV-RDIPRETiftEVDPDKMTQVFDNVITNAMKYSRgEKRVE 514
Cdd:PRK15347 467 SLEetallpLLDQAMLtiqgpaQSKSLTLR-------TFVgAHVPLYL---HLDSLRLRQILVNLLGNAVKFTE-TGGIR 535
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 515 FHVKHnpVHSRLTIRIKDNGIGIPINKVDKIFDRFFRVDKartrKMGGTGLGLAISKEIVEAHNGRIWANSVEGQGTSIF 594
Cdd:PRK15347 536 LRVKR--HEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADT----HSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFS 609
|
250
....*....|
gi 517997229 595 ITLPCEKIEE 604
Cdd:PRK15347 610 LVLPLNEYAP 619
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
492-593 |
6.75e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 71.06 E-value: 6.75e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 492 MTQVFDNVITNAMKYSRGEKrVEFHVKHNPVHSRLTIRIKDNGIGIPINKVDKIFDRFFrVDKARTRKMG-GTGLGLAIS 570
Cdd:cd16953 1 LGQVLRNLIGNAISFSPPDT-GRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFY-TERPANEAFGqHSGLGLSIS 78
|
90 100
....*....|....*....|...
gi 517997229 571 KEIVEAHNGRIWANSVEGQGTSI 593
Cdd:cd16953 79 RQIIEAHGGISVAENHNQPGQVI 101
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
167-588 |
8.22e-15 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 77.80 E-value: 8.22e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 167 IESNINQVYDQLSNINQ-----------IFIVGTGISLIITVILG-FFIARTITKPITDMRNQTVEMSKGNYTQRVKIYG 234
Cdd:COG4192 299 ISGLVGNSREQLVALNQetaqlvqqsgiLLLAIALLSLLLAVLINyFYVRRRLVKRLNALSDAMAAIAAGDLDVPIPVDG 378
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 235 NDEIGELAlafNNLskRVQEAQANtesEKRRldsvithmsdgviatdrrgrvriindmalkmlgkskeevsghfifevlD 314
Cdd:COG4192 379 NDEIGRIA---RLL--RVFRDQAI---EKTQ------------------------------------------------E 402
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 315 LQDEFSLEELNENNdsvLIDINEEegiiarvnfstIVQdtgfvTGYIAVLHDVteqqqiererrefVANVSHELRTPLTS 394
Cdd:COG4192 403 LETEIEERKRIEKN---LRQTQDE-----------LIQ-----AAKMAVVGQT-------------MTSLAHELNQPLNA 450
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 395 MNSYI----EALEEGawrDESIAPQFLSVTREETERMIRLVNDLLHLSKMDNETETItkeiVDFNMFINKIINRHEMTAK 470
Cdd:COG4192 451 MSMYLfsakKALEQE---NYAQLPTSLDKIEGLIERMDKIIKSLRQFSRKSDTPLQP----VDLRQVIEQAWELVESRAK 523
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 471 DTTFVRDIPRETiFTEVDPDKMTQVFDNVITNAMKYSRGEKRVEFHVKHNPVHsrLTIRIKDNGIGIPInkVDKIFDRFF 550
Cdd:COG4192 524 PQQITLHIPDDL-MVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAEN--LRVAISDNGNGWPL--VDKLFTPFT 598
|
410 420 430
....*....|....*....|....*....|....*....
gi 517997229 551 rvdkarTRKMGGTGLGLAISKEIVEAHNGRIW-ANSVEG 588
Cdd:COG4192 599 ------TTKEVGLGLGLSICRSIMQQFGGDLYlASTLER 631
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
361-598 |
1.82e-14 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 76.94 E-value: 1.82e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 361 IAVLHDVTEQQQIERERRE--------------FVANVSHELRTPLTSMNSYIE-----ALEEGAWRdesiapqFLSVTR 421
Cdd:PRK10841 417 ICVLVDVSARVKMEESLQEmaqaaeqasqsksmFLATVSHELRTPLYGIIGNLDllqtkELPKGVDR-------LVTAMN 489
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 422 EETERMIRLVNDLLHLSKMdnETETITKEIVDFN--MFINKII-NRHEMTAKDT----TFVR-DIPrETIFTevDPDKMT 493
Cdd:PRK10841 490 NSSSLLLKIISDILDFSKI--ESEQLKIEPREFSprEVINHITaNYLPLVVKKRlglyCFIEpDVP-VALNG--DPMRLQ 564
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 494 QVFDNVITNAMKYSRGEKRVeFHVKHNpvHSRLTIRIKDNGIGIPINKVDKIFDRFFRVDKARTRKMGGTGLGLAISKEI 573
Cdd:PRK10841 565 QVISNLLSNAIKFTDTGCIV-LHVRVD--GDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKL 641
|
250 260
....*....|....*....|....*.
gi 517997229 574 VEAHNGRIWANSVEGQGtSIF-ITLP 598
Cdd:PRK10841 642 INMMDGDISVDSEPGMG-SQFtIRIP 666
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
369-598 |
7.71e-14 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 74.94 E-value: 7.71e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 369 EQQQIERERREFVANVSHELRTPLTSMNSYIEALEegawrDESIAPQ---FLSVTREETERMIRLVNDLLHLSKMD--NE 443
Cdd:PRK11466 436 EAEKASQAKSAFLAAMSHEIRTPLYGILGTAQLLA-----DNPALNAqrdDLRAITDSGESLLTILNDILDYSAIEagGK 510
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 444 TETITKEIVDFNMFINKIIN------RHEMTAKDTTFVRDIPRetiFTEVDPDKMTQVFDNVITNAMKYS-RGEKRVEFH 516
Cdd:PRK11466 511 NVSVSDEPFEPRPLLESTLQlmsgrvKGRPIRLATDIADDLPT---ALMGDPRRIRQVITNLLSNALRFTdEGSIVLRSR 587
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 517 VKHnpvhSRLTIRIKDNGIGIPINKVDKIFDRFFRVdkarTRKMGGTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFIT 596
Cdd:PRK11466 588 TDG----EQWLVEVEDSGCGIDPAKLAEIFQPFVQV----SGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLR 659
|
..
gi 517997229 597 LP 598
Cdd:PRK11466 660 LP 661
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
266-598 |
9.92e-14 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 72.81 E-value: 9.92e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 266 LDSVIThmsdGVIATDRRGRVRIINDMALKMLGKSKEEVSGHfifEVLDLQDEFSL------EELNENN---DSVLIDIN 336
Cdd:PRK11073 13 LNSLIN----SILLLDDDLAIHYANPAAQQLLAQSSRKLFGT---PLPELLSYFSLnielmrESLQAGQgftDNEVTLVI 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 337 EEEGIIARVNFSTIVQdtgfvtGYIAV-LHDVTEQQQIERER---------REFVANVSHELRTPLTSMNSYIEALEEgA 406
Cdd:PRK11073 86 DGRSHILSLTAQRLPE------GMILLeMAPMDNQRRLSQEQlqhaqqvaaRDLVRGLAHEIKNPLGGLRGAAQLLSK-A 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 407 WRDESIApQFLSVTREETERMIRLVNDLLHLSKMDNETETITKEIVDfnmfinKIINRHEMTAKDT-TFVRD----IPRe 481
Cdd:PRK11073 159 LPDPALT-EYTKVIIEQADRLRNLVDRLLGPQRPGTHVTESIHKVAE------RVVQLVSLELPDNvRLIRDydpsLPE- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 482 tifTEVDPDKMTQVFDNVITNA---MKYSRGE----KRVEFHVKHNPVHSRLT--IRIKDNGIGIPINKVDKIFdrFFRV 552
Cdd:PRK11073 231 ---LAHDPDQIEQVLLNIVRNAlqaLGPEGGTitlrTRTAFQLTLHGERYRLAarIDIEDNGPGIPPHLQDTLF--YPMV 305
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 517997229 553 dkarTRKMGGTGLGLAISKEIVEAHNGRIWANSVEGQgTSIFITLP 598
Cdd:PRK11073 306 ----SGREGGTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLP 346
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
369-601 |
1.58e-13 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 70.80 E-value: 1.58e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 369 EQQQIERERREFVA----NVSHELrtplTSMNSYIEALEEGAWRDESIAPQFLSVTREETERMIRLVNDLLH-LSKMDNE 443
Cdd:COG4585 46 AEEAREEERRRIARelhdGVGQSL----SAIKLQLEAARRLLDADPEAAREELEEIRELAREALAELRRLVRgLRPPALD 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 444 TETITKEIVDFnmfINKIINRHEMtakDTTFVRDIPREtiftEVDPDKMTQVFDNV---ITNAMKYSRGeKRVEFHVKHN 520
Cdd:COG4585 122 DLGLAAALEEL---AERLLRAAGI---RVELDVDGDPD----RLPPEVELALYRIVqeaLTNALKHAGA-TRVTVTLEVD 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 521 PvhSRLTIRIKDNGIGIPINKVdkifdrffrvdkartrkmGGTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFITLPCE 600
Cdd:COG4585 191 D--GELTLTVRDDGVGFDPEAA------------------PGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPLA 250
|
.
gi 517997229 601 K 601
Cdd:COG4585 251 A 251
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
492-598 |
1.96e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 66.66 E-value: 1.96e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 492 MTQVFDNVITNAM---KYSRGE----KRVEFHVK--HNPVHSRLTIRIKDNGIGIPINKVDKIFDRFFrvdkarTRKMGG 562
Cdd:cd16918 1 LIQVFLNLVRNAAqalAGSGGEiilrTRTQRQVTlgHPRHRLALRVSVIDNGPGIPPDLQDTIFYPMV------SGRENG 74
|
90 100 110
....*....|....*....|....*....|....*.
gi 517997229 563 TGLGLAISKEIVEAHNGRIWANSVEGQgTSIFITLP 598
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
256-379 |
5.14e-13 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 71.34 E-value: 5.14e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 256 QANTESEKRRLDSVITHMSDGVIATDRRGRVRIINDMALKMLGKSKEEVSGHFIFEVLdlqDEFSLEELNENNDSVLIDI 335
Cdd:COG3829 3 ELELKELEEELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVTELI---PNSPLLEVLKTGKPVTGVI 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 517997229 336 NEEEGIIARVNFSTI-VQDTGFVTGYIAVLHDVTEQQQIERERRE 379
Cdd:COG3829 80 QKTGGKGKTVIVTAIpIFEDGEVIGAVETFRDITELKRLERKLRE 124
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
470-585 |
9.62e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 65.73 E-value: 9.62e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 470 KDTTFVRDIPRETIFTeVDPDKMTQVFDNVITNAMKYSrgEKRVEFHVKHNPVHsrLTIRIKDNGIGIPINKVDKIFDRF 549
Cdd:cd16954 17 KGVSISLDISPELRFP-GERNDLMELLGNLLDNACKWC--LEFVEVTARQTDGG--LHLIVDDDGPGVPESQRSKIFQRG 91
|
90 100 110
....*....|....*....|....*....|....*.
gi 517997229 550 FRVDKARTrkmgGTGLGLAISKEIVEAHNGRIWANS 585
Cdd:cd16954 92 QRLDEQRP----GQGLGLAIAKEIVEQYGGELSLSD 123
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
488-588 |
1.23e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 64.41 E-value: 1.23e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 488 DPDKMTQVFDNVITNAMKYSRGEKRVEFHVKHNpvHSRLTIRIKDNGIGIPINKVDKIFDRFFRVDKARTRKmGGTGLGL 567
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDE--EEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSG-GHYGMGL 77
|
90 100
....*....|....*....|..
gi 517997229 568 AISKEIVEAHNGRIW-ANSVEG 588
Cdd:cd16975 78 YIAKNLVEKHGGSLIiENSQKG 99
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
494-590 |
1.27e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 64.40 E-value: 1.27e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 494 QVFDNVITNAMKYSRGEKRVEFHVKHNPVHSRLTIRIKDNGIGIPINKVDKIFDRFFrvdkaRTRKMG-GTGLGLAISKE 572
Cdd:cd16976 3 QVLMNLLQNALDAMGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFF-----TTKPVGkGTGLGLSISYG 77
|
90
....*....|....*...
gi 517997229 573 IVEAHNGRIWANSVEGQG 590
Cdd:cd16976 78 IVEEHGGRLSVANEEGAG 95
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
94-388 |
2.23e-12 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 69.53 E-value: 2.23e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 94 RFIDKDQIIIATSKQSNRTIINQKANDSSIQKALSLGQENSDTVLKDYGEGKQRVWIKNMPVVTGDGLIGDIYIESNINQ 173
Cdd:COG3850 29 LSLLALLLLLERTLLRLLSLLASAGLLAALLAALLLLLSLGLLALLLALLLLLLLLLLAALLSLLLLLLLLLLLLLLLLL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 174 VYDQLSNINQIFIVGTGISLIITVILGFFIARTITKPITDMRNQTVEMSKGNYTQRVKIYGNDEIGELALAFNNLSKRVQ 253
Cdd:COG3850 109 LLLAAAINRKLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFNRMADELQ 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 254 EAQANTESEKRRLDSVITHMSDGVIATDRRGRVRIINDMALKMLGKSKEEVSGHFIFEVLDLQDEFSLEELNENNDSVLI 333
Cdd:COG3850 189 ELYAELEEEEELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELLALNILAGLLELLLA 268
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 517997229 334 DINEEEGIIARVNFSTIVQDTGFVTGYIAVLHDVTEQQQIERERREFVANVSHEL 388
Cdd:COG3850 269 LLLLLLASALLLLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQAI 323
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
370-588 |
2.63e-12 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 69.29 E-value: 2.63e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 370 QQQIERERReFVANVSHELRTPLTSMNSYIE----ALEEGAWRDESiapqfLSVTREETERMIRLVNDLLHLSKMDNETE 445
Cdd:PRK10337 231 HAMMVRERR-FTSDAAHELRSPLAALKVQTEvaqlSDDDPQARKKA-----LLQLHAGIDRATRLVDQLLTLSRLDSLDN 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 446 TITKEIVDFNMFINKIINRHEMTAK--DTTFVRDIPRETIFTEVDPDKMTQVFDNVITNAMKYSRGEKRVEFHVKHNpvh 523
Cdd:PRK10337 305 LQDVAEIPLEDLLQSAVMDIYHTAQqaGIDVRLTLNAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNAR--- 381
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 517997229 524 srlTIRIKDNGIGIPINKVDKIFDRFFRvdkARTRKMGGTGLGLAISKEIVEAHNGRI-WANSVEG 588
Cdd:PRK10337 382 ---NFTVRDNGPGVTPEALARIGERFYR---PPGQEATGSGLGLSIVRRIAKLHGMNVsFGNAPEG 441
|
|
| HAMP |
pfam00672 |
HAMP domain; |
202-254 |
4.68e-12 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 61.10 E-value: 4.68e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 517997229 202 FIARTITKPITDMRNQTVEMSKGNYTQRVKIYGNDEIGELALAFNNLSKRVQE 254
Cdd:pfam00672 1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
208-251 |
4.83e-12 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 60.54 E-value: 4.83e-12
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 517997229 208 TKPITDMRNQTVEMSKGNYTQRVKIYGNDEIGELALAFNNLSKR 251
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAER 44
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
254-379 |
6.79e-12 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 66.20 E-value: 6.79e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 254 EAQANTESEKRRLDSVITHMSDGVIATDRRGRVRIINDMALKMLGKSKEEVSGHFIFEVLDLQDEFSLEELNENNDSVLI 333
Cdd:COG2202 1 TAEEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLPPEDDDEFLELLRAALAGGG 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 517997229 334 DINEE--------EGIIARVNFSTIVQDTGFVTGYIAVLHDVTEQQQIERERRE 379
Cdd:COG2202 81 VWRGElrnrrkdgSLFWVELSISPVRDEDGEITGFVGIARDITERKRAEEALRE 134
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
14-488 |
8.45e-12 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 68.22 E-value: 8.45e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 14 LVIVYVLLIIIGMQIIGLYFTNSLEKEMTETFKTNISQNAKQIELGIEKIYADGNDSGNTQKDIQNLLNEYANRNEMIEI 93
Cdd:COG2770 43 LLLLLALLLLLLLLLLLLLAALVLLALLLAAALLLLLLLLSLVALAALLLALLLLLLLALLLLLAALLLLLLLAALALLL 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 94 RFIDKDQIIIATSKQSNRTIINQKANDSSIQKALSLGQENSDTVLKDYGEGKQRVWIKNMPVVTGDGLIGDIYIESNINQ 173
Cdd:COG2770 123 LLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAALALALGAGELLLLADLAAAIAALLAALLLLLLGGLLLVV 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 174 VYDQLSNINQIFIVGTGISLIITVILGFFIARTITKPITDMRNQTVEMSKGNYTQRVKIYGNDEIGELALAFNNLSKRVQ 253
Cdd:COG2770 203 LLEAALAALLLLLLLALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNRMADSLR 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 254 EAQANTESEKRRLDSVITHMSDGVIATDRRGRVRIINDMALKMLGKSKEEVSGHFIFEVLDLQDEFSLEELNENNDSVLI 333
Cdd:COG2770 283 ESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLL 362
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 334 DINEEEGIIARVNFSTIVQDTGFVTGYIAVLHDVTEQQQIERERREFVANVSHELRTPLTSMNSYIEALEEGAWRDESIA 413
Cdd:COG2770 363 LALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAALELAA 442
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 517997229 414 PQFLSVTREETERMIRLVNDLLHLSKMDNETETITKEIVDFNMFINKIINRHEMTAKDTTFVRDIPRETIFTEVD 488
Cdd:COG2770 443 AAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALELLLLEEEEEAGAAAEELAEELLLLEGLLL 517
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
373-598 |
9.90e-12 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 66.92 E-value: 9.90e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 373 IERERrEFVANVSHELRTPLTSMNSYIEALEEGAWRDesIAPQflsVTReeTERMIRLVNDLLHLSKMDNETETITKEIV 452
Cdd:PRK10755 134 LDQER-LFTADVAHELRTPLAGIRLHLELLEKQHHID--VAPL---IAR--LDQMMHTVEQLLQLARAGQSFSSGHYQTV 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 453 DFnmfINKII--NRHEM----TAKDTTFVRDIPRETIFTEVDPDKMTQVFDNVITNAMKYSRGEKRVEFHVKHNPVHSRL 526
Cdd:PRK10755 206 KL---LEDVIlpSQDELsemlEQRQQTLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVL 282
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 517997229 527 TIRikDNGIGIPINKVDKIFDRFFRVDkartRKMGGTGLGLAISKEIVEAHNGR-IWANSVEGQGTSIFITLP 598
Cdd:PRK10755 283 AVE--DEGPGIDESKCGELSKAFVRMD----SRYGGIGLGLSIVSRITQLHHGQfFLQNRQERSGTRAWVWLP 349
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
205-257 |
1.24e-11 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 59.95 E-value: 1.24e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 517997229 205 RTITKPITDMRNQTVEMSKGNYTQRVKIYGNDEIGELALAFNNLSKRVQEAQA 257
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
19-277 |
1.84e-11 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 66.97 E-value: 1.84e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 19 VLLIIIGMQIIGLYFTNSLEKEMTETFKTNISQNAKQIELGIEKIYADGNDSGNTQKDIQNLLNEYANRNEMIEIRFIDK 98
Cdd:COG0840 18 ALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLALLLLLLALLA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 99 DQIIIATSKQSNRTIINQKANDSSIQKALSLGQENSDTVLKDYGEGKQRVWIKNMPVVTGDGLIGDIYIESNINQVYDQL 178
Cdd:COG0840 98 LALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALLEAAALALAAA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 179 SNINQIFIVGTGISLIITVILGFFIARTITKPITDMRNQTVEMSKGNYTQRVKIYGNDEIGELALAFNNLSKRVQEAQAN 258
Cdd:COG0840 178 ALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENLRELVGQ 257
|
250
....*....|....*....
gi 517997229 259 TESEKRRLDSVITHMSDGV 277
Cdd:COG0840 258 VRESAEQVASASEELAASA 276
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
488-598 |
2.83e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 60.63 E-value: 2.83e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 488 DPDKMTQVFDNVITNAMKYSRGEKRVEFHVK---HNPVHSRLTIRIKDNGIGIPINKVDKIFDRFFrvdkarTRKMGGTG 564
Cdd:cd16944 1 DTTQISQVLTNILKNAAEAIEGRPSDVGEVRirvEADQDGRIVLIVCDNGKGFPREMRHRATEPYV------TTRPKGTG 74
|
90 100 110
....*....|....*....|....*....|....
gi 517997229 565 LGLAISKEIVEAHNGRIWANSVEGQGTSIFITLP 598
Cdd:cd16944 75 LGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
28-601 |
1.06e-10 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 64.27 E-value: 1.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 28 IIGLYFTNSLEKEMTETFKTNISQNAKQIELGIEKIYADGNDSGNTQKDIQNLLNEYANRNEMIEIRFIDKDQIIIATSK 107
Cdd:COG2972 1 LSKSLSLLSIVLLLLILLLLVLLILLLSLLLIILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 108 QSNRTIINQKANDSSIQKALSLGQENSDTVLKDYGEGKQRVWIKNMPVVTGDGLIG-DIYIESNINQVYDQLSNINQIFI 186
Cdd:COG2972 81 LILLLLLLLLLLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGwTLVSLIPKSELFRGLFSLRRLIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 187 VGTGISLIITVILGFFIARTITKPITDMRNQTVEMSKGNYTqRVKIYGNDEIGELALAFNNLSKRVQEAQANTESEKRRL 266
Cdd:COG2972 161 LIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLV-RLEVSGNDEIGILARSFNEMVERIKELIEEVYELELEK 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 267 dsvithmsdgviatdrrgrvriiNDMALKMLgkskeevsghfifevldlqdefsleelnenndsvlidineeegiiarvn 346
Cdd:COG2972 240 -----------------------KEAELKAL------------------------------------------------- 247
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 347 fstivqdtgfvtgyiavlhdvteQQQIereRREFVANVshelrtpLTSMNSYIEalEEGAwrdesiapqflsvtrEETER 426
Cdd:COG2972 248 -----------------------QAQI---NPHFLFNT-------LNSIRWLAE--LEDP---------------EEAEE 277
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 427 MIRLVNDLLHLS-KMDNETETITKEIvdfnMFINKIINRHEMTAKDT-TFVRDIPrETIFTEVDPDKMTQVF-DNVITNA 503
Cdd:COG2972 278 MLEALSKLLRYSlSKGDELVTLEEEL----ELIKSYLEIQKLRFGDRlEVEIEID-EELLDLLIPKLILQPLvENAIEHG 352
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 504 MKYSRGEKRVEFHVKHNpvHSRLTIRIKDNGIGIPINKVDKIFDRFfrvdkarTRKMGGTGLGLAISKEIVEAHNG---R 580
Cdd:COG2972 353 IEPKEGGGTIRISIRKE--GDRLVITVEDNGVGMPEEKLEKLLEEL-------SSKGEGRGIGLRNVRERLKLYYGeeyG 423
|
570 580
....*....|....*....|.
gi 517997229 581 IWANSVEGQGTSIFITLPCEK 601
Cdd:COG2972 424 LEIESEPGEGTTVTIRIPLEE 444
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
498-598 |
9.62e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 56.14 E-value: 9.62e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 498 NVITNAMKYS----RGEKRVEFHVKHNpvHSRLTIRIKDNGIGIPINKVDKIFDRFFrvdkaRTRKMGGTGLGLAISKEI 573
Cdd:cd16915 7 NLIDNALDALaatgAPNKQVEVFLRDE--GDDLVIEVRDTGPGIAPELRDKVFERGV-----STKGQGERGIGLALVRQS 79
|
90 100
....*....|....*....|....*
gi 517997229 574 VEAHNGRIWANSVEGQGTSIFITLP 598
Cdd:cd16915 80 VERLGGSITVESEPGGGTTFSIRIP 104
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
488-581 |
1.27e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 55.93 E-value: 1.27e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 488 DPDKMTQVFDNVITNAMKYSR--GEKRVEFHVKHNPVhsrlTIRIKDNGIGIPINKVDKIFDRFFRVDKARTRKMGgTGL 565
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPegGLIALQLEADTEGI----ELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQKS-TGL 75
|
90
....*....|....*.
gi 517997229 566 GLAISKEIVEAHNGRI 581
Cdd:cd16945 76 GLAFVQEVAQLHGGRI 91
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
500-598 |
4.02e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 53.71 E-value: 4.02e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 500 ITNAMKYSRGEkRVEFHVKHNPvhSRLTIRIKDNGIGipinkvdkifdrFFRVDKArtrkmGGTGLGLAISKEIVEAHNG 579
Cdd:cd16917 9 LTNALKHAGAS-RVRVTLSYTA--DELTLTVVDDGVG------------FDGPAPP-----GGGGFGLLGMRERAELLGG 68
|
90
....*....|....*....
gi 517997229 580 RIWANSVEGQGTSIFITLP 598
Cdd:cd16917 69 TLTIGSRPGGGTRVTARLP 87
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
526-598 |
5.52e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 54.31 E-value: 5.52e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 517997229 526 LTIRIKDNGIGIPINKVDKIFDRFFRvdkarTRKMG-GTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFITLP 598
Cdd:cd16919 48 VCLEVSDTGSGMPAEVLRRAFEPFFT-----TKEVGkGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
250-377 |
6.82e-09 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 56.96 E-value: 6.82e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 250 KRVQEAQAntESEkRRLDSVITHMSDGVIATDRRGRVRIINDMALKMLGKSKEEVSGHFIFEVLDLQD----EFSLEELN 325
Cdd:COG2202 126 KRAEEALR--ESE-ERLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKSLLDLLHPEDrerlLELLRRLL 202
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 517997229 326 ENNDSVL---IDINEEEGIIARVNFSTI-VQDTGFVTGYIAVLHDVTEQQQIERER 377
Cdd:COG2202 203 EGGRESYeleLRLKDGDGRWVWVEASAVpLRDGGEVIGVLGIVRDITERKRAEEAL 258
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
264-327 |
4.02e-08 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 50.48 E-value: 4.02e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 517997229 264 RRLDSVITHMSDGVIATDRRGRVRIINDMALKMLGKSKEEVSGHFIFEVLDLQDEFSLEELNEN 327
Cdd:smart00091 1 ERLRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHPEDRERVQEALQR 64
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
273-367 |
6.25e-08 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 51.09 E-value: 6.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 273 MSDGVIATDRRGRVRIINDMALKMLGKSKEEVSGHFIFEVLDLQDEFSLEELNENNDS--------VLIDINEEEGIIAR 344
Cdd:cd00130 1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLLSggepvtleVRLRRKDGSVIWVL 80
|
90 100
....*....|....*....|...
gi 517997229 345 VNFSTIVQDTGFVTGYIAVLHDV 367
Cdd:cd00130 81 VSLTPIRDEGGEVIGLLGVVRDI 103
|
|
| sensory_box |
TIGR00229 |
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ... |
261-377 |
3.43e-07 |
|
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]
Pssm-ID: 272971 [Multi-domain] Cd Length: 124 Bit Score: 49.21 E-value: 3.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 261 SEKRrLDSVITHMSDGVIATDRRGRVRIINDMALKMLGKSKEEVSGHFIFEVLDLQDEFSLEELNENNDSVLIDINEEEG 340
Cdd:TIGR00229 1 SEER-YRAIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRNVLELIPEEDREEVRERIERRLEGEPEPVSEER 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 517997229 341 IIARVNFSTI--------VQDTGFVTGYIAVLHDVTEQQQIERER 377
Cdd:TIGR00229 80 RVRRKDGSEIwvevsvspIRTNGGELGVVGIVRDITERKEAEEAL 124
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
264-367 |
6.00e-07 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 48.18 E-value: 6.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 264 RRLDSVITHMSDGVIATDRRGRVRIINDMALKMLGKSKEEVSGHFIFEVLDLQDEFSLEE-----LNENNDSVLIDINEE 338
Cdd:pfam00989 1 EDLRAILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIPEEDDAEVAEllrqaLLQGEESRGFEVSFR 80
|
90 100 110
....*....|....*....|....*....|...
gi 517997229 339 ----EGIIARVNFSTIVQDTGFVTGYIAVLHDV 367
Cdd:pfam00989 81 vpdgRPRHVEVRASPVRDAGGEILGFLGVLRDI 113
|
|
| TyrR |
COG3283 |
Transcriptional regulator TyrR of aromatic amino acids metabolism [Transcription, Amino acid ... |
259-313 |
1.08e-05 |
|
Transcriptional regulator TyrR of aromatic amino acids metabolism [Transcription, Amino acid transport and metabolism];
Pssm-ID: 442513 [Multi-domain] Cd Length: 514 Bit Score: 48.26 E-value: 1.08e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 517997229 259 TESEKRRLDSVITHMSDGVIATDRRGRVRIINDMALKMLGKSKEEVSGHFIFEVL 313
Cdd:COG3283 75 SEREHLELDALLEALPDPVFSIDLKGKIELANPAALSLLGLSEEELIGQPLSELL 129
|
|
| PAS_9 |
pfam13426 |
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ... |
284-369 |
1.59e-05 |
|
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463873 [Multi-domain] Cd Length: 93 Bit Score: 43.60 E-value: 1.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 284 GRVRIINDMALKMLGKSKEEVSGHFIFEVLDLQDEFSLEELNENNDSVLIDINEE------EGIIARVNFSTIVQDTGFV 357
Cdd:pfam13426 2 GRIIYVNDAALRLLGYTREELLGKSITDLFAEPEDSERLREALREGKAVREFEVVlyrkdgEPFPVLVSLAPIRDDGGEL 81
|
90
....*....|..
gi 517997229 358 TGYIAVLHDVTE 369
Cdd:pfam13426 82 VGIIAILRDITE 93
|
|
| PRK10600 |
PRK10600 |
nitrate/nitrite two-component system sensor histidine kinase NarX; |
167-260 |
1.94e-05 |
|
nitrate/nitrite two-component system sensor histidine kinase NarX;
Pssm-ID: 182581 [Multi-domain] Cd Length: 569 Bit Score: 47.74 E-value: 1.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 167 IESNINQVYDQLSNINQIFIVGTGISLIITVilgFFIARTITKPItdmrNQTVEM----SKGNYTQRVKIYGNDEIGELA 242
Cdd:PRK10600 112 FDHTTEMRIETVVLVHRVFAVFMALLLVFTI---IWLRRRLLQPW----RQLLSManavSHRDFTQRANISGRDEMAMLG 184
|
90 100
....*....|....*....|....*....
gi 517997229 243 LAFNNLS-----------KRVQEAQANTE 260
Cdd:PRK10600 185 TALNNMSaelaesyavleQRVQEKTAGLE 213
|
|
| HATPase_PDK-like |
cd16929 |
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ... |
457-598 |
4.72e-05 |
|
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.
Pssm-ID: 340406 [Multi-domain] Cd Length: 169 Bit Score: 44.25 E-value: 4.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 457 FINKIINRHEMTAKDTTFVRDIPRETIFTevdPDKMTQVFDNVITNAMkysrgEKRVEFHVKHNPVH-----------SR 525
Cdd:cd16929 12 EARVLCDDYYLSSPELEIEGDPSIRFPYV---PSHLYYILFELLKNAM-----RATVESHGDDSDDLppikvtvakgdED 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 526 LTIRIKDNGIGIPINKVDKIF-------------DRFFRVDKARTRKMGGTGLGLAISKEIVEAHNGRIWANSVEGQGTS 592
Cdd:cd16929 84 LTIKISDRGGGIPREDLARLFsymystapqpsldDFSDLISGTQPSPLAGFGYGLPMSRLYAEYFGGDLDLQSMEGYGTD 163
|
....*.
gi 517997229 593 IFITLP 598
Cdd:cd16929 164 VYIYLK 169
|
|
| PAS_8 |
pfam13188 |
PAS domain; PAS domains are involved in many signalling proteins where they are used as a ... |
264-326 |
5.60e-05 |
|
PAS domain; PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. This domain recognizes oxygen and CO (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463802 [Multi-domain] Cd Length: 65 Bit Score: 41.38 E-value: 5.60e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 517997229 264 RRLDSVITHMSDGVIATDRRGRVRIINDMALKMLGKSKEEVSGHFIFEVLDLQDEFSLEELNE 326
Cdd:pfam13188 1 ERLRALFESSPDGILVLDEGGRIIYVNPAALELLGYELLGELLGELLDLLDPLLEDALELLRE 63
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
452-604 |
6.46e-05 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 45.67 E-value: 6.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 452 VDFNMFINKIIN--RHEMTAKDTTFVRDIPretiFTEVDPDKMTQ---VFDNVITNAMKY-----SRGEKRVEFHVKHNp 521
Cdd:COG3920 359 VDLRDYLRELLEplRDSYGGRGIRIELDGP----DVELPADAAVPlglILNELVTNALKHaflsgEGGRIRVSWRREDG- 433
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 522 vhsRLTIRIKDNGIGIPINkvdkifdrffrVDKARTRkmggtGLGLAISKEIVEAHNGRIwaNSVEGQGTSIFITLPCEK 601
Cdd:COG3920 434 ---RLRLTVSDNGVGLPED-----------VDPPARK-----GLGLRLIRALVRQLGGTL--ELDRPEGTRVRITFPLAE 492
|
...
gi 517997229 602 IEE 604
Cdd:COG3920 493 LAA 495
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
384-598 |
7.72e-05 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 45.43 E-value: 7.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 384 VSHELRTPLTSMNSYIEALEEGAwRDESIAPQFLSVT----REETERMIRLVNDLLHLS---KMDNETetitkeiVDFNM 456
Cdd:PRK13557 170 IAHDFNNLLQVMSGYLDVIQAAL-SHPDADRGRMARSveniRAAAERAATLTQQLLAFArkqRLEGRV-------LNLNG 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 457 FINKIINRHEMT-AKDTTFVRDIPRETIFTEVDPDKMTQVFDNVITN---AMKySRGEKRVE----------FHVKHNPV 522
Cdd:PRK13557 242 LVSGMGELAERTlGDAVTIETDLAPDLWNCRIDPTQAEVALLNVLINardAMP-EGGRVTIRtrnveiededLAMYHGLP 320
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 517997229 523 HSR-LTIRIKDNGIGIPINKVDKIFDRFFrvdkaRTRKMG-GTGLGLAISKEIVEAHNGRIWANSVEGQGTSIFITLP 598
Cdd:PRK13557 321 PGRyVSIAVTDTGSGMPPEILARVMDPFF-----TTKEEGkGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFP 393
|
|
| PRK09776 |
PRK09776 |
putative diguanylate cyclase; Provisional |
262-376 |
1.10e-04 |
|
putative diguanylate cyclase; Provisional
Pssm-ID: 182070 [Multi-domain] Cd Length: 1092 Bit Score: 45.43 E-value: 1.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 262 EKRRLDSVITHMSDGVIATDRRGRVRIINDMALKMLGKSKEEVSGHFIFEVLDLQDEFSLEELnENNDSVLID-----IN 336
Cdd:PRK09776 534 EKERLHITLDSIGEAVVCTDMAMKVTFMNPVAEKMTGWTQEEALGVPLLTVLHITFGDNGPLM-ENIYSCLTSrsaayLE 612
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 517997229 337 EEEGIIARVNFSTIVQDT--------GFVTGYIAVLHDVTEQQQIERE 376
Cdd:PRK09776 613 QDVVLHCRSGGSYDVHYSitplstldGENIGSVLVIQDVTESRKMLRQ 660
|
|
| HATPase_RsbT-like |
cd16934 |
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine ... |
475-593 |
1.45e-04 |
|
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.
Pssm-ID: 340411 [Multi-domain] Cd Length: 117 Bit Score: 41.59 E-value: 1.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 475 VRDIPRETIFTEVDPDKMTQVFDNVITNAMKYSrGEKRVEFHVKHNPVHSRLTIRIKDNGIGIPinkvdkifdrffRVDK 554
Cdd:cd16934 9 ARELARRLGLSEVRQAEIATAVTELARNLLKHA-GGGQVLLEVVAEGGRVALEILAVDQGPGIA------------DVDE 75
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 517997229 555 ART---RKMGGTGLGLAISKEIveAHNGRIwaNSVEGQGTSI 593
Cdd:cd16934 76 ALRdgfSTGGGLGLGLGGVRRL--ADEFDL--HSAPGRGTVV 113
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
474-568 |
2.99e-04 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 41.05 E-value: 2.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 474 FVRDIPRETIFTEVDPDKMTQVFDNVITNAMKYSRGEK-----RVEFHVKHNpvhsRLTIRIKDNGIGIPINKVDkifdr 548
Cdd:COG2172 17 AVRALLRELGLDEDDADDLVLAVSEAVTNAVRHAYGGDpdgpvEVELELDPD----GLEIEVRDEGPGFDPEDLP----- 87
|
90 100
....*....|....*....|
gi 517997229 549 ffrvDKARTRKMGGTGLGLA 568
Cdd:COG2172 88 ----DPYSTLAEGGRGLFLI 103
|
|
| PAS_4 |
pfam08448 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
272-372 |
9.99e-04 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain is associated to signalling systems and works as a signal sensor domain. It recognizes differently substituted aromatic hydrocarbons, oxygen, different dodecanoic acids, autoinducers, 3,5-dimethyl-pyrazin-2-ol and N-alanyl-aminoacetone (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 312075 [Multi-domain] Cd Length: 110 Bit Score: 38.93 E-value: 9.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 272 HMSDGVIATDRRGRVRIINDMALKMLGKSKEEVSGHFIFEVL--DLQDEFS--LEELNENNDSV----LIDINEEEGIIa 343
Cdd:pfam08448 3 SLPDALAVLDPDGRVRYANAAAAELFGLPPEELLGKTLAELLppEDAARLEraLRRALEGEEPIdfleELLLNGEERHY- 81
|
90 100
....*....|....*....|....*....
gi 517997229 344 RVNFSTIVQDTGFVTGYIAVLHDVTEQQQ 372
Cdd:pfam08448 82 ELRLTPLRDPDGEVIGVLVISRDITERRR 110
|
|
| PRK11388 |
PRK11388 |
DNA-binding transcriptional regulator DhaR; Provisional |
256-380 |
5.88e-03 |
|
DNA-binding transcriptional regulator DhaR; Provisional
Pssm-ID: 183114 [Multi-domain] Cd Length: 638 Bit Score: 39.66 E-value: 5.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517997229 256 QANTESEKRRLDSVITHMSDGVIATDRRGRVRIINDMALKMLGKSKEEVSGHFIFEVLDLQDEFSLEELNENN-DSVLID 334
Cdd:PRK11388 195 LAESNRHLNQLNALLESMDDGVIAWDEQGNLQFLNAQAARLLRLDATASQGRAITELLTLPAVLQQAIKQAHPlKHVEVT 274
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 517997229 335 I-NEEEGIIARVNFSTIVQDTGfvTGYIAVLHDVTE-----QQQIERERREF 380
Cdd:PRK11388 275 FeSQGQFIDAVITLKPIIEGQG--TSFILLLHPVEQmrqlmTSQLGKVSHTF 324
|
|
| |
