|
Name |
Accession |
Description |
Interval |
E-value |
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
6-602 |
0e+00 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 1064.75 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 6 FFQSIHLKFVLIYMLLILIAMQVIGVYFVRELEKSLVQSFKDSLTQQTNLLSYNLKQEFAKEREkTDPPLENAIKTSITD 85
Cdd:NF033092 1 FFRSIHFKIVLIYVLLILIAMQIIGVYFVRQLETQLLNNFKESINLRANLLSYNLEQELSKEDE-DDETLEEDIRTILND 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 86 FASDrkkDIQEVRVIDPNRRLLAISNSSKQGMVGKTITDITVQRAIVQKKAEGKIEKDGKTGHRVQVMATPIEGEKGKII 165
Cdd:NF033092 80 FNNN---DISEIQVIDAKGTILGTSDPSNQSIVGQKTTDSDVKRALLGGKDNEKILIDPEDNNRVYVLATPIKSSNGEVV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 166 GVIHIVASMEDVYKQMKDINQIFATGTVIALLVTAVLGILLAQTITRPISDMRRQAIEMAKGNYSRKVKVHSHDEIGQLA 245
Cdd:NF033092 157 GAIYIEASMESVYDQMNNINLIFATGTLIALVITAVLGILLARTITRPIKEMRKQALAMAKGDFSRKVKVYGNDEIGQLA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 246 LAFNNLSKKLQQARSSTESERRKLSSVLSHMTDGVIATDRKGDIILLNDPAEKMLNVSRETALNQSVLEVLGIQEEFTLD 325
Cdd:NF033092 237 EAFNNLTKRLQEAQATTESERRKLDSVLSHMTDGVIATDRRGRVILINDPALEMLNVSRETVLGQSILDVLGLEEEYTLR 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 326 HLYEEPDSVLLDFSTRNEPYILRASFSVIQKETGKANGLIAVLYDVTEQERIDRERREFVANVSHELRTPLTTMRSYLEA 405
Cdd:NF033092 317 DLLEEQDSLLLDFSTEEEPLILRANFSVIQRESGFINGLIAVLHDVTEQEKIEQERREFVANVSHELRTPLTTMRSYLEA 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 406 LSDGAWQDPNIAPQFLTVTQEETERMIRLVNALLQLSKLDSTEHRLMKEWVDFTDFFNNVIDRFEM-SKEQNVIFKRSFS 484
Cdd:NF033092 397 LADGAWKDPELAPRFLGVTQNETERMIRLVNDLLQLSRMDSKDYKLNKEWVNFNEFFNYIIDRFEMiLKNKNITFKREFP 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 485 KKSRFIDMDADKITQVLYNIISNALKYSPEGGTVTYRLRDREDMLEISVSDQGMGIPKENVEKIFERFYRVDKARSRQMG 564
Cdd:NF033092 477 KRDLWVEIDTDKITQVLDNIISNAIKYSPEGGTITFRLLETHNRIIISISDQGLGIPKKDLDKIFDRFYRVDKARSRKMG 556
|
570 580 590
....*....|....*....|....*....|....*...
gi 517594622 565 GTGLGLAIAKEMIEAHGGSIWAKSEEGKGTTIYFTLPM 602
Cdd:NF033092 557 GTGLGLAIAKEVVEAHGGRIWAESEEGKGTTIYFTLPY 594
|
|
| HK_VicK |
NF033093 |
cell wall metabolism sensor histidine kinase VicK; This model describes the protein VicK (or ... |
227-611 |
2.79e-133 |
|
cell wall metabolism sensor histidine kinase VicK; This model describes the protein VicK (or WalK) as found in Streptococcus pneumoniae, This protein is shorter than the WalK of Staphylococcus aureus, although apparently is functionally similar. Compare to model NF033092 (HK_WalK). VicK is a sensor histidine kinase involved in regulating cell wall metabolism. Its two component system partner is the response regulatory VicR.
Pssm-ID: 467965 [Multi-domain] Cd Length: 448 Bit Score: 397.55 E-value: 2.79e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 227 GNYSRKVKVHSHDEIGQLALAFNNLSKKLQQARSSTESERRKLSSVLSHMTDGVIATDRKGDIILLNDPAEKMLNVSRET 306
Cdd:NF033093 54 GDYSEVLDMQGDPELTELTNSLNDLSEVFRLTHENLEQEKNRLASILSYMTDGVLATNRRGQIIMINDTAQKQLNVKREE 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 307 ALNQSVLEVLGIQEEFTLDHLYEEPDSVLLDFSTRNEPYI-LRASFSVIQKETGKANGLIAVLYDVTEQERIDRERREFV 385
Cdd:NF033093 134 ALNMNILDLLDIDDEYDLRDLITKTPELTLDSRDENGEFLsLRVRFALIRRESGFISGLVAVLHDTTEQEKEERERRLFV 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 386 ANVSHELRTPLTTMRSYLEALSDGAWQDPnIAPQFLTVTQEETERMIRLVNALLQLSKLDSTEHRLMKEWVDFTDFFNNV 465
Cdd:NF033093 214 SNVSHELRTPLTSVKSYLEALDEGALSEP-VAPSFIKVSLDETNRMMRMISDLLSLSRIDNQTSHLDVELTNFTAFITFI 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 466 IDRFEMSKEQNVI------FKRSFSKKSRFIDMDADKITQVLYNIISNALKYSPEGGTVTYRLRDREDMLEISVSDQGMG 539
Cdd:NF033093 293 LNRFDQIKSQDTEtgkkyeIVRDYPITSIWVEIDTDKMTQVIDNILNNAIKYSPDGGKITVSMKTTDTQLIISISDEGLG 372
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 517594622 540 IPKENVEKIFERFYRVDKARSRQMGGTGLGLAIAKEMIEAHGGSIWAKSEEGKGTTIYFTLPMAKEE--EDDWE 611
Cdd:NF033093 373 IPKKDLPLIFDRFYRVDKARSRAQGGTGLGLAIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDAvkDDEWE 446
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
288-605 |
5.90e-109 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 332.67 E-value: 5.90e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 288 DIILLNDPAEKMLNVSRETALNQSVLEVLGIQEEFTLDHLYEEPDSVLLDFSTRNEPYILRASFSVIQKETGKANGLIAV 367
Cdd:COG5002 72 LLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAV 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 368 LYDVTEQERIDRERREFVANVSHELRTPLTTMRSYLEALSDGAWQDPNIAPQFLTVTQEETERMIRLVNALLQLSKLDST 447
Cdd:COG5002 152 ERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESG 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 448 EHRLMKEWVDFTDFFNNVIDRFE-MSKEQNVIFKRSFSKKSRFIDMDADKITQVLYNIISNALKYSPEGGTVTYRLRDRE 526
Cdd:COG5002 232 ELKLEKEPVDLAELLEEVVEELRpLAEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREED 311
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 517594622 527 DMLEISVSDQGMGIPKENVEKIFERFYRVDKARSRQMGGTGLGLAIAKEMIEAHGGSIWAKSEEGKGTTIYFTLPMAKE 605
Cdd:COG5002 312 DQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLARE 390
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
187-607 |
2.33e-95 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 298.80 E-value: 2.33e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 187 IFATGTVIALLVTAVLGILLAQTITRPISDMRRQAIEMAKGNYSRKVKVHSHDEIGQLALAFNNLSKKLQQARSSTESER 266
Cdd:COG5000 10 LLLLIALLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKEQREELEERR 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 267 RKLSSVLSHMTDGVIATDRKGDIILLNDPAEKMLNVSRETALNQSVLEVLG-IQEEFTLDHLYEEPDSVLLDFsTRNEPY 345
Cdd:COG5000 90 RYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGKPLEELLPeLDLAELLREALERGWQEEIEL-TRDGRR 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 346 ILRASFSVIQketgkANGLIAVLYDVTEQERIDRER--REFVANVSHELRTPLTTMRSYLE----ALSDGAWQDPNIAPQ 419
Cdd:COG5000 169 TLLVRASPLR-----DDGYVIVFDDITELLRAERLAawGELARRIAHEIKNPLTPIQLSAErlrrKLADKLEEDREDLER 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 420 FLTVTQEETERMIRLVNALLQLSKLDSTEhrlmKEWVDFTDFFNNVIDRFEMS-KEQNVIFKRSFSKKSRFIDMDADKIT 498
Cdd:COG5000 244 ALDTIIRQVDRLKRIVDEFLDFARLPEPQ----LEPVDLNELLREVLALYEPAlKEKDIRLELDLDPDLPEVLADRDQLE 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 499 QVLYNIISNALKYSPEGGTVTYRLRDREDMLEISVSDQGMGIPKENVEKIFERFYrvdkarSRQMGGTGLGLAIAKEMIE 578
Cdd:COG5000 320 QVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFF------TTKPKGTGLGLAIVKKIVE 393
|
410 420
....*....|....*....|....*....
gi 517594622 579 AHGGSIWAKSEEGKGTTIYFTLPMAKEEE 607
Cdd:COG5000 394 EHGGTIELESRPGGGTTFTIRLPLAEEAE 422
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
373-605 |
3.80e-84 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 262.92 E-value: 3.80e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 373 EQERIDRERREFVANVSHELRTPLTTMRSYLEALSDGAWQDPNIAPQFLTVTQEETERMIRLVNALLQLSKLDSTEHRLM 452
Cdd:COG2205 8 ELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLESGKLSLE 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 453 KEWVDFTDFFNNVIDRFEMS-KEQNVIFKRSFSKKSRFIDMDADKITQVLYNIISNALKYSPEGGTVTYRLRDREDMLEI 531
Cdd:COG2205 88 LEPVDLAELLEEAVEELRPLaEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREGDGVRI 167
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 517594622 532 SVSDQGMGIPKENVEKIFERFYRVDKARSRqmGGTGLGLAIAKEMIEAHGGSIWAKSEEGKGTTIYFTLPMAKE 605
Cdd:COG2205 168 SVSDNGPGIPEEELERIFERFYRGDNSRGE--GGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAES 239
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
263-600 |
6.63e-79 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 252.90 E-value: 6.63e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 263 ESERRKLSSVLSHMTDGVIATDRKGDIILLNDPAEKMLNVSRETALNQSVLEVLGiQEEFtLDHL----YEEPdsvLLDF 338
Cdd:TIGR02966 2 SALLSRFRAAAQALPDAVVVLDEEGQIEWCNPAAERLLGLRWPDDLGQRITNLIR-HPEF-VEYLaagrFSEP---LELP 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 339 STRNEPYILrasfsVIQKETGKANGLIAVLYDVTEQERIDRERREFVANVSHELRTPLTTMRSYLEALSDGAWQDPNIAP 418
Cdd:TIGR02966 77 SPINSERVL-----EIRIAPYGEEQKLLVARDVTRLRRLEQMRRDFVANVSHELRTPLTVLRGYLETLADGPDEDPEEWN 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 419 QFLTVTQEETERMIRLVNALLQLSKLDSTEHRLMKEWVDFTDFFNNVIDRFE-MS--KEQNVIFKrsfskksrfIDM--- 492
Cdd:TIGR02966 152 RALEIMLEQSQRMQSLVEDLLTLSRLESAASPLEDEPVDMPALLDHLRDEAEaLSqgKNHQITFE---------IDGgvd 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 493 ---DADKITQVLYNIISNALKYSPEGGTVTYRLRDREDMLEISVSDQGMGIPKENVEKIFERFYRVDKARSRQMGGTGLG 569
Cdd:TIGR02966 223 vlgDEDELRSAFSNLVSNAIKYTPEGGTITVRWRRDGGGAEFSVTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLG 302
|
330 340 350
....*....|....*....|....*....|.
gi 517594622 570 LAIAKEMIEAHGGSIWAKSEEGKGTTIYFTL 600
Cdd:TIGR02966 303 LAIVKHVLSRHHARLEIESELGKGSTFSFIF 333
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
288-603 |
5.20e-77 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 247.90 E-value: 5.20e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 288 DIILLNDPAEKMLNVSRETALNQSVLEVLGIQEEFTLDHLYEEPDSVLLDFSTRNEPYILRASFSVIQKETGKANGLIAV 367
Cdd:COG0642 17 LLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 368 LYDVTEQERIDRERREFVANVSHELRTPLTTMRSYLEALSDGAwqDPNIApQFLTVTQEETERMIRLVNALLQLSKLDST 447
Cdd:COG0642 97 LALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEEL--DEEQR-EYLETILRSADRLLRLINDLLDLSRLEAG 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 448 EHRLMKEWVDFTDFFNNVIDRFE-MSKEQNVIFKRSFSKKSRFIDMDADKITQVLYNIISNALKYSPEGGTVTYRLRDRE 526
Cdd:COG0642 174 KLELEPEPVDLAELLEEVVELFRpLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREG 253
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 517594622 527 DMLEISVSDQGMGIPKENVEKIFERFYRVDKARSRqmGGTGLGLAIAKEMIEAHGGSIWAKSEEGKGTTIYFTLPMA 603
Cdd:COG0642 254 DRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRG--GGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPLA 328
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
162-606 |
2.61e-65 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 224.85 E-value: 2.61e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 162 GKIIGVIHIVASMEDVYKQMKDINQ-IFAtgtVIALLVtaVLGILLAQTITRPISDMRRQAIEmakgnysrKVKVHSHD- 239
Cdd:PRK11360 166 GEVIGYIWANELTEDIRRQAWKMDRrIYA---VLAAGL--VIGLLLIFLLSRRFSANVDIIKD--------GLSTLENDl 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 240 ---------EIGQLALAFNNLSKKLQQARSSTESerrklssVLSHMTDGVIATDRKGDIILLNDPAEKMLNVSRETALNQ 310
Cdd:PRK11360 233 strlpplpgELGEISQAINNLAQALRETRSLNEL-------ILESIADGVIAIDRQGKITTMNPAAEVITGLQRHELVGK 305
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 311 SVLEVLGIQEEF------TLDHLYEEPDsVLLDFSTRNEPYILRASFSVIQKETGKANGLIAVLYDVTE----QERIDRE 380
Cdd:PRK11360 306 PYSELFPPNTPFasplldTLEHGTEHVD-LEISFPGRDRTIELSVSTSLLHNTHGEMIGALVIFSDLTErkrlQRRVARQ 384
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 381 RR-----EFVANVSHELRTPLTTMRSYLEALSDGAWQDPNiaPQFLTVTQEETERMIRLVNALLQLSKldSTEHRLMKew 455
Cdd:PRK11360 385 ERlaalgELVAGVAHEIRNPLTAIRGYVQIWRQQTSDPPS--QEYLSVVLREVDRLNKVIDQLLEFSR--PRESQWQP-- 458
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 456 VDFTDFFNNVIDRFEMSKEQNVI-FKRSFSKKSRFIDMDADKITQVLYNIISNALKYSPEGGTVTYRL-RDREDMLEISV 533
Cdd:PRK11360 459 VSLNALVEEVLQLFQTAGVQARVdFETELDNELPPIWADPELLKQVLLNILINAVQAISARGKIRIRTwQYSDGQVAVSI 538
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 517594622 534 SDQGMGIPKENVEKIFERFYRVdKARsrqmgGTGLGLAIAKEMIEAHGGSIWAKSEEGKGTTIYFTLPMAKEE 606
Cdd:PRK11360 539 EDNGCGIDPELLKKIFDPFFTT-KAK-----GTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINPQG 605
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
263-609 |
1.84e-64 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 215.87 E-value: 1.84e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 263 ESERRKLSSVLSHMTDGVIATDRKGDIILLNDPAEKMLNVSRETALNQSVLEVLGIQEEFT--LDHLYEEPDSVL---LD 337
Cdd:COG3852 3 RESEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFPEDSPLRelLERALAEGQPVTereVT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 338 FSTRN-EPYILRASFSVIQKETGKaNGLIAVLYDVTEQERIDRERR---------EFVANVSHELRTPLTTMRSYLEALS 407
Cdd:COG3852 83 LRRKDgEERPVDVSVSPLRDAEGE-GGVLLVLRDITERKRLERELRraeklaavgELAAGLAHEIRNPLTGIRGAAQLLE 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 408 DGAwqDPNIAPQFLTVTQEETERMIRLVNALLQLSKLDSTEhrlmKEWVDFTDFFNNVIDRFEMSKEQNVIFKRSFSKKS 487
Cdd:COG3852 162 REL--PDDELREYTQLIIEEADRLNNLVDRLLSFSRPRPPE----REPVNLHEVLERVLELLRAEAPKNIRIVRDYDPSL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 488 RFIDMDADKITQVLYNIISNALKYSPEGGTVTYRLRDRE----------DMLEISVSDQGMGIPKENVEKIFERFYrvdk 557
Cdd:COG3852 236 PEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVERqvtlgglrprLYVRIEVIDNGPGIPEEILDRIFEPFF---- 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 517594622 558 arSRQMGGTGLGLAIAKEMIEAHGGSIWAKSEEGKGTTIYFTLPMAKEEEDD 609
Cdd:COG3852 312 --TTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQAEEEP 361
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
263-607 |
4.90e-52 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 186.33 E-value: 4.90e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 263 ESERrKLSSVLSHMTDGVIATDRKGDIILLNDPAEKMLNVSRETALNQSVLEVLGI--QEEFTLDHLYEEPDSVLLDF-- 338
Cdd:COG5809 138 ESEE-KFRLIFNHSPDGIIVTDLDGRIIYANPAACKLLGISIEELIGKSILELIHSddQENVAAFISQLLKDGGIAQGev 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 339 ---STRNEPYILRASFSVIqKETGKANGLIAVLYDVTEQERIDRERR---------EFVANVSHELRTPLTTMRSYLEAL 406
Cdd:COG5809 217 rfwTKDGRWRLLEASGAPI-KKNGEVDGIVIIFRDITERKKLEELLRkseklsvvgELAAGIAHEIRNPLTSLKGFIQLL 295
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 407 SDGAWQDPNiapQFLTVTQEETERMIRLVNALLQLSKLDStehrLMKEWVDFTDFFNNVIDRFE---MSKeqNVIFKRSF 483
Cdd:COG5809 296 KDTIDEEQK---TYLDIMLSELDRIESIISEFLVLAKPQA----IKYEPKDLNTLIEEVIPLLQpqaLLK--NVQIELEL 366
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 484 SKKSRFIDMDADKITQVLYNIISNALKYSPEGGTVTYRLRD-REDMLEISVSDQGMGIPKENVEKIFERFYrvdkarSRQ 562
Cdd:COG5809 367 EDDIPDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKAeDDDKVVISVTDEGCGIPEERLKKLGEPFY------TTK 440
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 517594622 563 MGGTGLGLAIAKEMIEAHGGSIWAKSEEGKGTTIYFTLPMAKEEE 607
Cdd:COG5809 441 EKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIKLSEQ 485
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
187-605 |
1.34e-51 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 185.37 E-value: 1.34e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 187 IFATGTVIALLVTAVLGILLAQTITRPISDMRRQAIEMAKGNYSRKVKVHSHDEIGQLALAFNNLSKKLQQARSSTESER 266
Cdd:COG4251 84 LLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLL 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 267 RKLSSVLSHMTDGVIATDRKGDIILLNDPAEKMLNVSRETALNQSVLEVLGIQEEFTLDHLYEEPDSVLLDFSTRNEPYI 346
Cdd:COG4251 164 LALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLIL 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 347 LRASFSVIQKETGKANGLIAVLYDVTEQ----ERIDRERREFVANVSHELRTPLTTMRSYLEAL-SDGAWQDPNIAPQFL 421
Cdd:COG4251 244 LLLLLILVLELLELRLELEELEEELEERtaelERSNEELEQFAYVASHDLREPLRKISGFSQLLeEDYGDKLDEEGREYL 323
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 422 TVTQEETERMIRLVNALLQLSKLDSTEHRLmkEWVDFTDFFNNVIDRFEMS-KEQNVIFKRSfskKSRFIDMDADKITQV 500
Cdd:COG4251 324 ERIRDAAERMQALIDDLLAYSRVGRQELEF--EPVDLNELLEEVLEDLEPRiEERGAEIEVG---PLPTVRGDPTLLRQV 398
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 501 LYNIISNALKYSPEG--GTVTYRLRDREDMLEISVSDQGMGIPKENVEKIFERFYRVDkaRSRQMGGTGLGLAIAKEMIE 578
Cdd:COG4251 399 FQNLISNAIKYSRPGepPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLH--SRDEYEGTGIGLAIVKKIVE 476
|
410 420
....*....|....*....|....*..
gi 517594622 579 AHGGSIWAKSEEGKGTTIYFTLPMAKE 605
Cdd:COG4251 477 RHGGRIWVESEPGEGATFYFTLPKAPA 503
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
364-601 |
3.19e-50 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 179.82 E-value: 3.19e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 364 LIAVLYDVTEQERIDRERREFVANVSHELRTPLTTMRSYLEALSDGAWQDPnIAPQFLTVTQEETERMIRLVNALLQLSK 443
Cdd:PRK11006 187 LLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQDQPLEGA-LREKALHTMREQTQRMEGLVKQLLTLSK 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 444 LDSTEHRLMKEWVDFTDFFNnVIDRFEMS---KEQNVIFKRSFSKKSRfidMDADKITQVLYNIISNALKYSPEGGTVTY 520
Cdd:PRK11006 266 IEAAPTIDLNEKVDVPMMLR-VLEREAQTlsqGKHTITFEVDNSLKVF---GNEDQLRSAISNLVYNAVNHTPEGTHITV 341
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 521 RLRDREDMLEISVSDQGMGIPKENVEKIFERFYRVDKARSRQMGGTGLGLAIAKEMIEAHGGSIWAKSEEGKGTTIYFTL 600
Cdd:PRK11006 342 RWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVL 421
|
.
gi 517594622 601 P 601
Cdd:PRK11006 422 P 422
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
304-603 |
9.25e-46 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 165.74 E-value: 9.25e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 304 RETALNQSVLEVLGIQEEFTLDHLYEEPDSVLLDFSTRNEPYILRASFSVIQKETGKANGLIAVLYDVTEQERIDRERR- 382
Cdd:COG4191 49 LLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRe 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 383 ---------------EFVANVSHELRTPLTTMRSYLEALSD--GAWQDPNIAPQFLTVTQEETERMIRLVNALLQLSKLD 445
Cdd:COG4191 129 lqeqlvqseklaalgELAAGIAHEINNPLAAILGNAELLRRrlEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRD 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 446 STEhrlmKEWVDFTDFFNNVIDRFEMS-KEQNVIFKRSFSKKSRFIDMDADKITQVLYNIISNALKYSPEG--GTVTYRL 522
Cdd:COG4191 209 EEE----REPVDLNELIDEALELLRPRlKARGIEVELDLPPDLPPVLGDPGQLEQVLLNLLINAIDAMEEGegGRITIST 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 523 RDREDMLEISVSDQGMGIPKENVEKIFERFY---RVDKarsrqmgGTGLGLAIAKEMIEAHGGSIWAKSEEGKGTTIYFT 599
Cdd:COG4191 285 RREGDYVVISVRDNGPGIPPEVLERIFEPFFttkPVGK-------GTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTIT 357
|
....
gi 517594622 600 LPMA 603
Cdd:COG4191 358 LPLA 361
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
492-603 |
1.06e-42 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 148.95 E-value: 1.06e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 492 MDADKITQVLYNIISNALKYSPEGGTVTYRLRDREDMLEISVSDQGMGIPKENVEKIFERFYRVDKaRSRQMGGTGLGLA 571
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|..
gi 517594622 572 IAKEMIEAHGGSIWAKSEEGKGTTIYFTLPMA 603
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGGTTFTITLPLE 111
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
384-601 |
1.50e-42 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 159.09 E-value: 1.50e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 384 FVANVSHELRTPLTTMRSYLE-ALSDgawqdPNIAPQF---LTVTQEETERMIRLVNALLQLSKLDSTEHRLMKEWVDFT 459
Cdd:TIGR01386 244 FSADLAHELRTPLTNLLGQTQvALSQ-----PRTGEEYrevLESNLEELERLSRMVSDMLFLARADNGQLALERVRLDLA 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 460 DFFNNVIDRFE-MSKEQNVIFKRSfskKSRFIDMDADKITQVLYNIISNALKYSPEGGTVTYRLRDREDMLEISVSDQGM 538
Cdd:TIGR01386 319 AELAKVAEYFEpLAEERGVRIRVE---GEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGP 395
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 517594622 539 GIPKENVEKIFERFYRVDKARSRQMGGTGLGLAIAKEMIEAHGGSIWAKSEEGKgTTIYFTLP 601
Cdd:TIGR01386 396 GIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDGK-TRFILRFP 457
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
497-600 |
3.55e-41 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 144.67 E-value: 3.55e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 497 ITQVLYNIISNALKYSPEGGTVTYRLRDREDMLEISVSDQGMGIPKENVEKIFERFYRVDKARSRqmGGTGLGLAIAKEM 576
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREG--GGTGLGLAIVRRI 78
|
90 100
....*....|....*....|....
gi 517594622 577 IEAHGGSIWAKSEEGKGTTIYFTL 600
Cdd:cd00075 79 VEAHGGRITVESEPGGGTTFTVTL 102
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
8-601 |
5.74e-41 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 155.95 E-value: 5.74e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 8 QSIHLKFVLIYMLLILIAMQVIGVYFVRELEKSLVQSFKDSLTQQTNL-LSYNLKQEFAKEREKTDPPLENAIKTSITDF 86
Cdd:NF040691 3 RSLQLRVVAITLLLSLVVILVLGVVLALQITNGLLDNRVDAALGDSRRaRTQAQSQLNASDASTSDSAQQLLRTTLLSVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 87 ASDRKKDIQEVRVidpnrrLLAISNSSKQGM----VGKTITDITVQRAIVQKKAEGK----------IEKDGKTGHRVqV 152
Cdd:NF040691 83 ASASGAMQGAFDV------VLLVPGDDPSGLgpraSGSVGLVSQIPEELREAVAGGQvaqqyqsvalPSGDGSSAPAL-V 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 153 MATPIEGEKGKIIGViHIVASMEDVYKQMKDINQIFATGTVIALLVTAVLGILLAQTITRPISDMRRQAIEMAKGNYSRK 232
Cdd:NF040691 156 VGTPVTLPVAGNYEL-YLLFPLEDEQSTLALVRGTLLLGGLALVVLLGLIAWLVTRQVVAPVRSAARTAERFAAGDLSER 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 233 VKVHSHDEIGQLALAFNNLSKKLQQArssteserrklssvlshmtdgviatdrkgdiillndpaekmlnvsretalnqsv 312
Cdd:NF040691 235 MPVKGEDDLARLARSFNQMADSLQRQ------------------------------------------------------ 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 313 levlgIQEeftldhlYEEpdsvlldfstrnepyilrasFSVIQketgkangliavlydvteqeridrerREFVANVSHEL 392
Cdd:NF040691 261 -----IRQ-------LEE--------------------LSRLQ--------------------------QRFVSDVSHEL 282
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 393 RTPLTTMRSYLEALSDGAWQ-DPNIA--PQFLtvtQEETERMIRLVNALLQLSKLDSTEHRLMKEWVDFTDFFNNVIDRF 469
Cdd:NF040691 283 RTPLTTIRMAADVIHDSRDDfDPATArsAELL---HTELDRFESLLSDLLEISRFDAGAAELDVEPVDLRPLVRRVVDAL 359
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 470 EMSKEQNVIFKRSFSKKSRFI-DMDADKITQVLYNIISNALKYSpEGGTVTYRLRDREDMLEISVSDQGMGIPKENVEKI 548
Cdd:NF040691 360 RQLAERAGVELRVDAPGTPVVaEVDPRRVERVLRNLVVNAIEHG-EGKPVVVTVAQDDTAVAVTVRDHGVGLKPGEVALV 438
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|...
gi 517594622 549 FERFYRVDKARSRQMGGTGLGLAIAKEMIEAHGGSIWAKSEEGKGTTIYFTLP 601
Cdd:NF040691 439 FDRFWRADPARARTTGGTGLGLAIALEDARLHGGWLEAWGRPGQGSQFRLTLP 491
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
337-611 |
1.32e-38 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 148.24 E-value: 1.32e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 337 DFSTRNEPyilrASfsviQKETGKA----NGLIAVLydvteqERIDRERREFVANVSHELRTPLTTMRSYLEALSDGAWQ 412
Cdd:PRK10549 206 DFTTRVTP----TS----RDELGRLaqdfNQLASTL------EKNEQMRRDFMADISHELRTPLAVLRGELEAIQDGVRK 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 413 dpnIAPQFLTVTQEETERMIRLVNALLQLSKLDSTEHRLMKEWVDFTDFFNNVI----DRFEmSK---------EQNVIF 479
Cdd:PRK10549 272 ---FTPESVASLQAEVGTLTKLVDDLHQLSLSDEGALAYRKTPVDLVPLLEVAGgafrERFA-SRgltlqlslpDSATVF 347
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 480 KrsfskksrfidmDADKITQVLYNIISNALKYSPEGGTVTYRLRDREDMLEISVSDQGMGIPKENVEKIFERFYRVDKAR 559
Cdd:PRK10549 348 G------------DPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSR 415
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 517594622 560 SRQMGGTGLGLAIAKEMIEAHGGSIWAKSEEGKGTTIYFTLPMakEEEDDWE 611
Cdd:PRK10549 416 NRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPL--ERDLQRE 465
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
246-601 |
3.51e-38 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 147.57 E-value: 3.51e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 246 LAFNNLSKKLQQaRSSTESERRKLSSVLSHMTDGVIATDRKGDIILLNDPAEKMLNVSRETALNQSVLEVLgiqEEFTLD 325
Cdd:COG5805 137 LALRDITKKKKI-EEILQEQEERLQTLIENSPDLICVIDTDGRILFINESIERLFGAPREELIGKNLLELL---HPCDKE 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 326 HLYEEPDSVLLDFSTR----------NEPYILRASFSVIQKETGKANGLIAVLYDVTEQERIDRERR---------EFVA 386
Cdd:COG5805 213 EFKERIESITEVWQEFiiereiitkdGRIRYFEAVIVPLIDTDGSVKGILVILRDITEKKEAEELMArseklsiagQLAA 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 387 NVSHELRTPLTTMRSYLEALSDGawqdPNIAPQFLTVTQEETERMIRLVNALLQLSKLDSTEhrlmKEWVDFTDFFNNVI 466
Cdd:COG5805 293 GIAHEIRNPLTSIKGFLQLLQPG----IEDKEEYFDIMLSELDRIESIISEFLALAKPQAVN----KEKENINELIQDVV 364
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 467 DRFEM-SKEQNVIFKRSFSKKSRFIDMDADKITQVLYNIISNALKYSPEGGTVTYRLRDREDMLEISVSDQGMGIPKENV 545
Cdd:COG5805 365 TLLETeAILHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERL 444
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 517594622 546 EKIFERFYrvdkarSRQMGGTGLGLAIAKEMIEAHGGSIWAKSEEGKGTTIYFTLP 601
Cdd:COG5805 445 KKLGEPFF------TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
374-601 |
7.34e-38 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 144.32 E-value: 7.34e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 374 QERIDRERReFVANVSHELRTPLTTMRSYLEALSDGAWQDPNIAP-----QFLTVTQEETERMIRLVNALLQLSKLDSTE 448
Cdd:PRK09303 145 LEQLKFKDR-VLAMLAHDLRTPLTAASLALETLELGQIDEDTELKpalieQLQDQARRQLEEIERLITDLLEVGRTRWEA 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 449 HRLMKEWVDFTDFFNNVIDRFEmskeqnvifKRSFSKKSRFI-----DM-----DADKITQVLYNIISNALKYSPEGGTV 518
Cdd:PRK09303 224 LRFNPQKLDLGSLCQEVILELE---------KRWLAKSLEIQtdipsDLpsvyaDQERIRQVLLNLLDNAIKYTPEGGTI 294
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 519 TYRLRDREDM-LEISVSDQGMGIPKENVEKIFERFYRVDkaRSRQMGGTGLGLAIAKEMIEAHGGSIWAKSEEGKGTTIY 597
Cdd:PRK09303 295 TLSMLHRTTQkVQVSICDTGPGIPEEEQERIFEDRVRLP--RDEGTEGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFH 372
|
....
gi 517594622 598 FTLP 601
Cdd:PRK09303 373 FTLP 376
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
499-602 |
4.42e-37 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 133.39 E-value: 4.42e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 499 QVLYNIISNALKYSPEGG-TVTYRLRDRED---MLEISVSDQGMGIPKENVEKIFERFYRVDKARSRQMGGTGLGLAIAK 574
Cdd:cd16922 3 QILLNLLGNAIKFTEEGEvTLRVSLEEEEEdgvQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAISK 82
|
90 100
....*....|....*....|....*...
gi 517594622 575 EMIEAHGGSIWAKSEEGKGTTIYFTLPM 602
Cdd:cd16922 83 KLVELMGGDISVESEPGQGSTFTFTLPL 110
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
375-601 |
7.67e-37 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 143.04 E-value: 7.67e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 375 ERIDRERREFVANVSHELRTPLTTMRSYLEALSDGAWQdpnIAPQFLTVTQEETERMIRLVNALLQLSKLDSTEHRLMKE 454
Cdd:NF012163 234 EKNEQMRRDFMADISHELRTPLAVLRAELEAIQDGIRK---FTPESLDSLQAEVGTLTKLVDDLHDLSMSDEGALAYQKA 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 455 WVDFTDFFNNVIDRFEMSKEQNVIFKRSFSKKSRFIDMDADKITQVLYNIISNALKYSPEGGTVTYRLRDREDMLEISVS 534
Cdd:NF012163 311 SVDLVPLLEVEGGAFRERFASAGLELEVSLPDSSLVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISASQRPKEVTLTVA 390
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 517594622 535 DQGMGIPKENVEKIFERFYRVDKARSRQMGGTGLGLAIAKEMIEAHGGSIWAKSEEGKGTTIYFTLP 601
Cdd:NF012163 391 DSAPGVSDEQLARLFERFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTLHAAHSPLGGLRIVVTLP 457
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
492-604 |
1.93e-36 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 131.72 E-value: 1.93e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 492 MDADKITQVLYNIISNALKYSPEGGTVTYRLRdREDMLEISVSDQGMGIPKENVEKIFERFYRVDKarsRQMGGTGLGLA 571
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLS-EGGELTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGLS 76
|
90 100 110
....*....|....*....|....*....|...
gi 517594622 572 IAKEMIEAHGGSIWAKSEEGKGTTIYFTLPMAK 604
Cdd:pfam02518 77 IVRKLVELLGGTITVESEPGGGTTVTLTLPLAQ 109
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
384-603 |
3.19e-35 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 138.75 E-value: 3.19e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 384 FVANVSHELRTPLTTMRSYLE-ALSDGawQDPNIAPQFLTVTQEETERMIRLVNALLQLSKLDSTEHRLMKEWVDFTDFF 462
Cdd:PRK09835 265 FSADIAHEIRTPITNLITQTEiALSQS--RSQKELEDVLYSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKMLDLADEV 342
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 463 NNVIDRFE-MSKEQNVIFKrsFSKKSRFIDMDADKITQVLYNIISNALKYSPEGGTVTYRLRDREDMLEISVSDQGMGIP 541
Cdd:PRK09835 343 GKVFDFFEaWAEERGVELR--FVGDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIA 420
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 517594622 542 KENVEKIFERFYRVDKARSRQMGGTGLGLAIAKEMIEAHGGSIWAKSeEGKGTTIYFTLPMA 603
Cdd:PRK09835 421 PEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTS-DARGTRFVISLPRL 481
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
362-609 |
1.11e-32 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 134.39 E-value: 1.11e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 362 NGLIAV------LYDVTEQERIDRERRE----FVANVSHELRTPLTTMRSYLEALS-DGAWQDPNIAPQFLTVTQEeTER 430
Cdd:PRK10490 635 TLLIANalerltLTASEEQARLASEREQlrnaLLAALSHDLRTPLTVLFGQAEILTlDLASEGSPHARQASEIRQQ-VLN 713
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 431 MIRLVNALLQLSKLDSTEHRLMKEWVDFTDFFNNVIDRFEMSKEQNVIfKRSFSKKSRFIDMDADKITQVLYNIISNALK 510
Cdd:PRK10490 714 TTRLVNNLLDMARIQSGGFNLRKEWLTLEEVVGSALQMLEPGLSGHPI-NLSLPEPLTLIHVDGPLFERVLINLLENAVK 792
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 511 YSPEGGTVTYRLRDREDMLEISVSDQGMGIPKENVEKIFERFYRVDKARSrqMGGTGLGLAIAKEMIEAHGGSIWAKSEE 590
Cdd:PRK10490 793 YAGAQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESA--IPGVGLGLAICRAIVEVHGGTIWAENRP 870
|
250 260
....*....|....*....|...
gi 517594622 591 GKGTTIYFTLPMAK----EEEDD 609
Cdd:PRK10490 871 EGGACFRVTLPLETppelEEFHE 893
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
384-603 |
2.81e-30 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 124.19 E-value: 2.81e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 384 FVANVSHELRTPLTTMRSYLEALSDGAwqDPNIAPQFLTVTQEETERMIRLVNALLQLSKLDSTEHRLMKEWVDFTDFFN 463
Cdd:PRK11100 259 YVQTLTHELKSPLAAIRGAAELLQEDP--PPEDRARFTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLE 336
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 464 NVIDRFEMSKEQ-NVIFKRSFSKKSrfIDMDADKITQVLYNIISNALKYSPEGGTVTYRLRDREDMLEISVSDQGMGIPK 542
Cdd:PRK11100 337 ELVEAREAQAAAkGITLRLRPDDAR--VLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPD 414
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 517594622 543 ENVEKIFERFY---RVDKARSrqmgGTGLGLAIAKEMIEAHGGSIWAKSEEGKGTTIYFTLPMA 603
Cdd:PRK11100 415 YALPRIFERFYslpRPANGRK----STGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPRH 474
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
497-602 |
2.92e-30 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 114.35 E-value: 2.92e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 497 ITQVLYNIISNALKYSPEggTVTYRLRDREDMLEISVSDQGMGIPKENVEKIFERFYRVDKARSRQMGGTGLGLAIAKEM 576
Cdd:cd16949 1 LARALENVLRNALRYSPS--KILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERA 78
|
90 100
....*....|....*....|....*.
gi 517594622 577 IEAHGGSIWAKSEEGKGTTIYFTLPM 602
Cdd:cd16949 79 IEQHGGKIKASNRKPGGLRVRIWLPA 104
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-601 |
1.39e-29 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 112.56 E-value: 1.39e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 493 DADKITQVLYNIISNALKYSPEGGTVTYRLRDREDMLEISVSDQGMGIPKENVEKIFERFYRVDKARSRQMGGTGLGLAI 572
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 517594622 573 AKEMIEAHGGSIWAKSEEGKGTTIYFTLP 601
Cdd:cd16946 81 CHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
503-604 |
3.22e-29 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 111.52 E-value: 3.22e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 503 NIISNALKYSPEGGTVTYRLRDREDMLEISVSDQGMGIPKENVEKIFERFYRVDKARSRQMGGTGLGLAIAKEMIEAHGG 582
Cdd:cd16952 7 NLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVMSRHDA 86
|
90 100
....*....|....*....|..
gi 517594622 583 SIWAKSEEGKGTTIYFTLPMAK 604
Cdd:cd16952 87 RLLIASELGKGSRFTCLFPSSR 108
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
371-605 |
8.30e-29 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 119.65 E-value: 8.30e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 371 VTEQERIdrerrefVANVSHELRTPLTTMR--SYLEALSDGAWQDpniapqfLTVTQEETERMIRLVNALLQLSKLDSTE 448
Cdd:PRK09470 240 MTSQQRL-------LSDISHELRTPLTRLQlaTALLRRRQGESKE-------LERIETEAQRLDSMINDLLVLSRNQQKN 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 449 HrLMKEWVDFTDFFNNVID--RFEMskEQNVI-FKRSFSKKSRFIDMDADKITQVLYNIISNALKYSPEggTVTYRLRDR 525
Cdd:PRK09470 306 H-LERETFKANSLWSEVLEdaKFEA--EQMGKsLTVSAPPGPWPINGNPNALASALENIVRNALRYSHT--KIEVAFSVD 380
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 526 EDMLEISVSDQGMGIPKENVEKIFERFYRVDKARSRQMGGTGLGLAIAKEMIEAHGGSIWA-KSEEGkGTTIYFTLPMAK 604
Cdd:PRK09470 381 KDGLTITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAeDSPLG-GLRLTIWLPLYK 459
|
.
gi 517594622 605 E 605
Cdd:PRK09470 460 R 460
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
373-603 |
1.42e-28 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 121.81 E-value: 1.42e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 373 EQERIDRERREFVANVSHELRTPLTTMRSYLEALSDGawQDPNIAPQFLTVTQEETERMIRLVNALLQLSKLDSTEHRLM 452
Cdd:TIGR02956 456 EAEEANRAKSAFLATMSHEIRTPLNGILGTLELLGDT--GLTSQQQQYLQVINRSGESLLDILNDILDYSKIEAGHLSIS 533
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 453 KEWVDFTDFFNNVIDRFEmSKEQNVIFKRSFSKKSR---FIDMDADKITQVLYNIISNALKYSPEgGTVTYRLRDREDM- 528
Cdd:TIGR02956 534 PRPFDLNALLDDVHHLMV-SRAQLKGIQLRLNIPEQlpnWWQGDGPRIRQVLINLVGNAIKFTDR-GSVVLRVSLNDDSs 611
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 517594622 529 LEISVSDQGMGIPKENVEKIFERFYRVDKARSrqMGGTGLGLAIAKEMIEAHGGSIWAKSEEGKGTTIYFTLPMA 603
Cdd:TIGR02956 612 LLFEVEDTGCGIAEEEQATLFDAFTQADGRRR--SGGTGLGLAISQRLVEAMDGELGVESELGVGSCFWFTLPLT 684
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
323-609 |
7.44e-28 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 119.28 E-value: 7.44e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 323 TLDHLYEEPDSVLLDFSTRNEPYILRasfsviqkeTGKANGLIAVLYDVTEQ-------ERIDRERREFVANVSHELRTP 395
Cdd:PRK11091 227 TYEQWLDYPDGRKACFELRKVPFYDR---------VGKRHGLMGFGRDITERkryqdalEKASRDKTTFISTISHELRTP 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 396 L------TTM----------RSYLEALSDGAWQDPNIapqfltvtqeetermirlVNALLQLSKLDSTEHRLMKEWVDFT 459
Cdd:PRK11091 298 LngivglSRIlldteltaeqRKYLKTIHVSAITLGNI------------------FNDIIDMDKMERRKLQLDNQPIDFT 359
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 460 DFFNNVID-----------RFEMSKEQNVifkrsfskkSRFIDMDADKITQVLYNIISNALKYSPEGGTVTYRLRDREDM 528
Cdd:PRK11091 360 DFLADLENlsglqaeqkglRFDLEPLLPL---------PHKVITDGTRLRQILWNLISNAVKFTQQGGVTVRVRYEEGDM 430
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 529 LEISVSDQGMGIPKENVEKIFERFYRV-DKARSRQMGGTGLGLAIAKEMIEAHGGSIWAKSEEGKGTTiyFTL----PMA 603
Cdd:PRK11091 431 LTFEVEDSGIGIPEDELDKIFAMYYQVkDSHGGKPATGTGIGLAVSKRLAQAMGGDITVTSEEGKGSC--FTLtihaPAV 508
|
....*.
gi 517594622 604 KEEEDD 609
Cdd:PRK11091 509 AEEVED 514
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
497-601 |
1.80e-27 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 106.64 E-value: 1.80e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 497 ITQVLYNIISNALKYSPEGGT--VTYRLRDREDMLEISVSDQGMGIPKENVEKIFERFYRVDkarSR-QMGGTGLGLAIA 573
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPprIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLH---SReEYEGTGVGLAIV 77
|
90 100
....*....|....*....|....*...
gi 517594622 574 KEMIEAHGGSIWAKSEEGKGTTIYFTLP 601
Cdd:cd16921 78 RKIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
386-609 |
3.43e-27 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 114.88 E-value: 3.43e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 386 ANVSHELRTPLTTMR---SYLEALSDGAWQDPNIApqflTVTQEETERMIRLVNALLQLSKldstEHRLMKEWVDFTDFF 462
Cdd:PRK10364 242 AGVAHEIRNPLSSIKglaKYFAERAPAGGEAHQLA----QVMAKEADRLNRVVSELLELVK----PTHLALQAVDLNDLI 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 463 NNVIDRFEMSKEQNVI-FKRSFSKKSRFIDMDADKITQVLYNIISNALKYSPEGGTVTYRLRDREDMLEISVSDQGMGIP 541
Cdd:PRK10364 314 NHSLQLVSQDANSREIqLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIA 393
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 517594622 542 KENVEKIFERFYrVDKARsrqmgGTGLGLAIAKEMIEAHGGSIWAKSEEGKGTTIYFTLPMAKEEEDD 609
Cdd:PRK10364 394 ADQLEAIFTPYF-TTKAE-----GTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVNITRRDP 455
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
493-601 |
5.19e-27 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 105.27 E-value: 5.19e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 493 DADKITQVLYNIISNALKYSPEGGTVTYRL-RDREDMLEISVSDQGMGIPKENVEKIFERFYRVDKARSRQMGGTGLGLA 571
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILeKFRLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80
|
90 100 110
....*....|....*....|....*....|
gi 517594622 572 IAKEMIEAHGGSIWAKSEEGKGTTIYFTLP 601
Cdd:cd16925 81 IVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
241-605 |
1.13e-26 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 112.25 E-value: 1.13e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 241 IGQLALAFNNLSKKLQQARSSTESERRKLSSVLSHMTDGVIATDRKGDIILLNDPAEKMLNVSretALNQSVLEVLgiqe 320
Cdd:COG3290 58 LILLLLLLLLLAALLLKLLEEIARLVEEREAVLESIREGVIAVDRDGRITLINDAARRLLGLD---AIGRPIDEVL---- 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 321 eftldhlYEEPDSVLLDFSTRNEPYILRASFSVIQKEtGKANGLIAVLYDVTEQERIDRE---RREFVANV---SHELRT 394
Cdd:COG3290 131 -------AEVLETGERDEEILLNGRVLVVNRVPIRDD-GRVVGAVATFRDRTELERLEEElegVKELAEALraqRHDFRN 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 395 PLTTMRSYLEAlsdGAWQDpniAPQFLTVTQEETERMIRLVNALLQLSKLDStehrlmkewvdftdFFNNVIDRfemSKE 474
Cdd:COG3290 203 HLHTISGLLQL---GEYDE---ALEYIDEISEELQELIDSLLSRIGNPVLAA--------------LLLGKAAR---ARE 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 475 QNVIFKRSFSKKSRFIDMDADKITQVLYNIISNAL----KYSPEGGTVTYRLRDREDMLEISVSDQGMGIPKENVEKIFE 550
Cdd:COG3290 260 RGIDLTIDIDSDLPDLPLSDTDLVTILGNLLDNAIeaveKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFE 339
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 517594622 551 RFYRvdkarSRQMGGTGLGLAIAKEMIEAHGGSIWAKSEEGKGTTIYFTLPMAKE 605
Cdd:COG3290 340 RGFS-----TKLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEGE 389
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
386-602 |
4.63e-25 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 107.00 E-value: 4.63e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 386 ANVSHELRTPLTTMRSYLEALSDGAWQ-DPNIAPQFLTvtqeETERMIRLVNALLQLSKLDSTEHRLMKEWVDFTDFFNN 464
Cdd:NF012226 143 AAIAHELRTPITILQGRLQGILDGVFEpDPALFKSLLN----QVEGLSHLVEDLRTLSLVENQQLRLNYESVDLKDSIEK 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 465 VIDRFEMSKEQ---NVIFKRSfskkSRFIDMDADKITQVLYNIISNALKYSpEGGTVTYRLRDREDMLEISVSDQGMGIP 541
Cdd:NF012226 219 VLKMFEDRLEQaqlTIVLNLT----ATPVFCDRRRIEQVLIALIDNAIRYA-NAGKLKISSSVIQDDWILQIEDEGPGIA 293
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 517594622 542 KENVEKIFERFYRVDKARSRQMGGTGLGLAIAKEMIEAHGGSI-WAKSEEGKGTTIyfTLPM 602
Cdd:NF012226 294 EEYQQDLFNPFFRLEQSRNKEFGGTGLGLAVVHAIVIAHKGSIeYSNSQGNSVFTI--KLPA 353
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
381-602 |
4.77e-25 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 110.98 E-value: 4.77e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 381 RREFVANVSHELRTPLTTMRSYLEALSdGAWQDPNIAPQFLTVTQEETERMIRLVNALLQLSKLDSTEHRLMKEWVDFTD 460
Cdd:PRK09959 712 KSQFLATMSHEIRTPISSIMGFLELLS-GSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWVDIPT 790
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 461 FFNNVIDRFEMSKEQNVIfkrSFSKKSRFID-----MDADKITQVLYNIISNALKYSPEGG----TVTYRLRDREDMLEI 531
Cdd:PRK09959 791 LVQNTCHSFGAIAASKSI---ALSCSSTFPDhylvkIDPQAFKQVLSNLLSNALKFTTEGAvkitTSLGHIDDNHAVIKM 867
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 517594622 532 SVSDQGMGIPKENVEKIFERFYRVdkARSRQMGGTGLGLAIAKEMIEAHGGSIWAKSEEGKGTTIYFTLPM 602
Cdd:PRK09959 868 TIMDSGSGLSQEEQQQLFKRYSQT--SAGRQQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPV 936
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
373-602 |
2.77e-23 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 105.11 E-value: 2.77e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 373 EQERIDRERREFVANVSHELRTPLTTMRSYLEALSDGawqdPNIAPQF--LTVTQEETERMIRLVNALLQLSKLDSTEHR 450
Cdd:PRK15347 390 RAEQANKRKSEHLTTISHEIRTPLNGVLGALELLQNT----PLTAEQMdlADTARQCTLSLLAIINNLLDFSRIESGQMT 465
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 451 LMKEWVDFTDFFNNVidrfeMSKEQNVIFKRSFSKKSrFI--------DMDADKITQVLYNIISNALKYSPEGGtVTYRL 522
Cdd:PRK15347 466 LSLEETALLPLLDQA-----MLTIQGPAQSKSLTLRT-FVgahvplylHLDSLRLRQILVNLLGNAVKFTETGG-IRLRV 538
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 523 RDREDMLEISVSDQGMGIPKENVEKIFERFYRVDKarsrQMGGTGLGLAIAKEMIEAHGGSIWAKSEEGKGTTIYFTLPM 602
Cdd:PRK15347 539 KRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADT----HSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLPL 614
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
381-601 |
6.51e-23 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 101.60 E-value: 6.51e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 381 RREFVANVSHELRTPLTTMRsYLEALSDGawqdpniapqfltVTQEETERMIR-------LVNALLQLSKLDSTEHRLMK 453
Cdd:PRK10604 212 KKQLIDGIAHELRTPLVRLR-YRLEMSDN-------------LSAAESQALNRdigqleaLIEELLTYARLDRPQNELHL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 454 EWVDFTDFFNNVIDRFEmSKEQNVIFKRSFSKKSRFIDMDADKITQVLYNIISNALKYSpeGGTVTYRLRDREDMLEISV 533
Cdd:PRK10604 278 SEPDLPAWLSTHLADIQ-AVTPEKTVRLDTPHQGDYGALDMRLMERVLDNLLNNALRYA--HSRVRVSLLLDGNQACLIV 354
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 517594622 534 SDQGMGIPKENVEKIFERFYRVDKARSRQMGGTGLGLAIAKEMIEAHGGSIWAKSEEGKGTTIYFTLP 601
Cdd:PRK10604 355 EDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWP 422
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
500-601 |
7.93e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 93.22 E-value: 7.93e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 500 VLYNIISNALKYSPEGGTVTYRLRDREDMLEISVSDQGMGIPKENVEKIFERFYRVDKarSRQMGGTGLGLAIAKEMIEA 579
Cdd:cd16923 4 VFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDN--SRNTEGAGLGLSIAKAIIEL 81
|
90 100
....*....|....*....|..
gi 517594622 580 HGGSIWAKSeEGKGTTIYFTLP 601
Cdd:cd16923 82 HGGSASAEY-DDNHDLFKVRLP 102
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-596 |
7.01e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 90.93 E-value: 7.01e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 493 DADKITQVLYNIISNALKYSPEGGTVTYRLRDReDMLEISVSDQGMGIPKENVEKIFERFYRVDKarsRQMGGTGLGLAI 572
Cdd:cd16940 10 DALLLFLLLRNLVDNAVRYSPQGSRVEIKLSAD-DGAVIRVEDNGPGIDEEELEALFERFYRSDG---QNYGGSGLGLSI 85
|
90 100
....*....|....*....|....
gi 517594622 573 AKEMIEAHGGSIWAKSEEGKGTTI 596
Cdd:cd16940 86 VKRIVELHGGQIFLGNAQGGGLEA 109
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
343-582 |
2.25e-21 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 95.81 E-value: 2.25e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 343 EPYILRASFSVIQKETGKANGLIAVLydvteQERIDRERrEFVANVSHELRTPLTTMRSYLEALSDGAWQD--PNIApqf 420
Cdd:PRK10755 105 TPIAIHSSTLEIEAVTSALNQLVSRL-----TSTLDQER-LFTADVAHELRTPLAGIRLHLELLEKQHHIDvaPLIA--- 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 421 ltvtqeETERMIRLVNALLQLSKLD---STEHRLMKEWVdftdffNNVID--RFEMS-----KEQNVIFKRSFSkkSRFI 490
Cdd:PRK10755 176 ------RLDQMMHTVEQLLQLARAGqsfSSGHYQTVKLL------EDVILpsQDELSemleqRQQTLLLPESAA--DITV 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 491 DMDADKITQVLYNIISNALKYSPEGGTVTYRLRDREDMLEISVSDQGMGIPKENVEKIFERFYRVDkarsRQMGGTGLGL 570
Cdd:PRK10755 242 QGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRMD----SRYGGIGLGL 317
|
250
....*....|..
gi 517594622 571 AIAKEMIEAHGG 582
Cdd:PRK10755 318 SIVSRITQLHHG 329
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
497-601 |
5.33e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 88.22 E-value: 5.33e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 497 ITQVLYNIISNALK----YSPEGGTVTYRL-RDREDMLEISVSDQGMGIPKENVEKIFERFYrvdkarSRQMGGTGLGLA 571
Cdd:cd16920 1 IQQVLINLVRNGIEamseGGCERRELTIRTsPADDRAVTISVKDTGPGIAEEVAGQLFDPFY------TTKSEGLGMGLS 74
|
90 100 110
....*....|....*....|....*....|
gi 517594622 572 IAKEMIEAHGGSIWAKSEEGKGTTIYFTLP 601
Cdd:cd16920 75 ICRSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
500-601 |
8.45e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 87.73 E-value: 8.45e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 500 VLYNIISNALKYSPEGGTVTYRLRDREDMLEISVSDQGMGIPKENVEKIFERFYRVDKARsRQMGGTGLGLAIAKEMIEA 579
Cdd:cd16948 9 IIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGR-NFQESTGMGLYLVKKLCDK 87
|
90 100
....*....|....*....|..
gi 517594622 580 HGGSIWAKSEEGKGTTIYFTLP 601
Cdd:cd16948 88 LGHKIDVESEVGEGTTFTITFP 109
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
499-596 |
9.53e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 87.63 E-value: 9.53e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 499 QVLYNIISNALKYSP-EGGTVTYRLRDREDMLEISVSDQGMGIPKENVEKIFERFYrVDKARSRQMG-GTGLGLAIAKEM 576
Cdd:cd16953 3 QVLRNLIGNAISFSPpDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFY-TERPANEAFGqHSGLGLSISRQI 81
|
90 100
....*....|....*....|
gi 517594622 577 IEAHGGSIWAKSEEGKGTTI 596
Cdd:cd16953 82 IEAHGGISVAENHNQPGQVI 101
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
379-591 |
1.08e-20 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 95.10 E-value: 1.08e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 379 RERReFVANVSHELRTPLTTMRSYLEA--LSDgawQDPNIAPQFLTVTQEETERMIRLVNALLQLSKLDSTEHRLMKEWV 456
Cdd:PRK10337 236 RERR-FTSDAAHELRSPLAALKVQTEVaqLSD---DDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDSLDNLQDVAEI 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 457 DFTDFFNN-VIDRFEMSKEQNVIFKrsfskksrfIDMDADKIT---QVLY------NIISNALKYSPEGGTVTYRLRDRe 526
Cdd:PRK10337 312 PLEDLLQSaVMDIYHTAQQAGIDVR---------LTLNAHPVIrtgQPLLlsllvrNLLDNAIRYSPQGSVVDVTLNAR- 381
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 517594622 527 dmlEISVSDQGMGIPKENVEKIFERFYRvdkARSRQMGGTGLGLAIAKEMIEAHGGSI-WAKSEEG 591
Cdd:PRK10337 382 ---NFTVRDNGPGVTPEALARIGERFYR---PPGQEATGSGLGLSIVRRIAKLHGMNVsFGNAPEG 441
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
383-601 |
3.50e-20 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 93.01 E-value: 3.50e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 383 EFVANVSHELRTPLTTMRSYLEALSDGAWQDPNiAPQFLTVTQEETERMIRLVNALLQLSKLDSTEHrlmkEWVDFTDFF 462
Cdd:COG5806 203 ELAASIAHEVRNPLTVVRGFIQLLQEPELSDEK-RKQYIRIALEELDRAEAIITDYLTFAKPQPEKL----EKIDVSEEL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 463 NNVIDRFE-MSKEQNVIFKRSFSKKSrFIDMDADKITQVLYNIISNALKYSPEGGTVTYRLRDREDMLEISVSDQGMGIP 541
Cdd:COG5806 278 EHVIDVLSpYANMNNVEIQTELEPGL-YIEGDRQKLQQCLINIIKNGIEAMPNGGTLTIDVSIDKNKVIISIKDTGVGMT 356
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 542 KENVEKIFERFYrvdkarSRQMGGTGLGLAIAKEMIEAHGGSIWAKSEEGKGTTIYFTLP 601
Cdd:COG5806 357 KEQLERLGEPYF------STKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITLP 410
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
500-601 |
3.94e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 85.56 E-value: 3.94e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 500 VLYNIISNALKYSPEggTVTYRLRDREDMLEISVSDQGMGIPKENVEKIFERFYRVDKARSRQMGGTGLGLAIAKEMIEA 579
Cdd:cd16939 4 ALDNLLRNALRYAHR--TVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVALW 81
|
90 100
....*....|....*....|..
gi 517594622 580 HGGSIWAKSEEGKGTTIYFTLP 601
Cdd:cd16939 82 HGGHVECDDSELGGACFRLTWP 103
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-600 |
8.75e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 85.26 E-value: 8.75e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 493 DADKITQVLYNIISNALKYSPEGGTVTYRLRDREDMLEISVSDQGMGIPKENVEKIFERFYRVDKARSRQMGGTGLGLAI 572
Cdd:cd16947 17 NTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQGNGLGLTI 96
|
90 100
....*....|....*....|....*...
gi 517594622 573 AKEMIEAHGGSIWAKSEEGKGTTIYFTL 600
Cdd:cd16947 97 TKRLAESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
497-601 |
1.04e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 84.40 E-value: 1.04e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 497 ITQVLYNIISNALKYSPEGGTVTYRLRDREDMLEISVSDQGMGIPKENVEKIFERFYrvdkaRSRQMG-GTGLGLAIAKE 575
Cdd:cd16943 4 LNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFF-----TTKPVGeGTGLGLSLSYR 78
|
90 100
....*....|....*....|....*.
gi 517594622 576 MIEAHGGSIWAKSEEGKGTTIYFTLP 601
Cdd:cd16943 79 IIQKHGGTIRVASVPGGGTRFTIILP 104
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
497-601 |
1.33e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 84.04 E-value: 1.33e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 497 ITQVLYNIISNALKYSpeGGTVTYRLRDREDMLEISVSDQGMGIPKENVEKIFERFYRVDKARSrqMGGTGLGLAIAKEM 576
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQRI 76
|
90 100
....*....|....*....|....*
gi 517594622 577 IEAHGGSIWAKSEEGKGTTIYFTLP 601
Cdd:cd16950 77 SDAHGGSLTLANRAGGGLCARIELP 101
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
272-602 |
1.59e-19 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 90.14 E-value: 1.59e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 272 VLSHMTDGVIATDRKGDIILLNDPAEKMLNVSRETALNQSVLEVLGiqeEFTLD-HLYEEP--------DSVLLdFSTRN 342
Cdd:PRK11073 12 ILNSLINSILLLDDDLAIHYANPAAQQLLAQSSRKLFGTPLPELLS---YFSLNiELMRESlqagqgftDNEVT-LVIDG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 343 EPYILRASFSVIqketgkANGLIAV-LYDVTEQERIDRER---------REFVANVSHELRTPLTTMRSYLEALSDgAWQ 412
Cdd:PRK11073 88 RSHILSLTAQRL------PEGMILLeMAPMDNQRRLSQEQlqhaqqvaaRDLVRGLAHEIKNPLGGLRGAAQLLSK-ALP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 413 DPNIApQFLTVTQEETERMIRLVNALLqlskldSTEHRLMKEWVDFTDFFNNVIDRFEMSKEQNVIFKRSFSKKSRFIDM 492
Cdd:PRK11073 161 DPALT-EYTKVIIEQADRLRNLVDRLL------GPQRPGTHVTESIHKVAERVVQLVSLELPDNVRLIRDYDPSLPELAH 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 493 DADKITQVLYNIISNALK-YSPEGGTVTYRLRDREDML----------EISVSDQGMGIPKENVEKIFerfYRVDKARSr 561
Cdd:PRK11073 234 DPDQIEQVLLNIVRNALQaLGPEGGTITLRTRTAFQLTlhgeryrlaaRIDIEDNGPGIPPHLQDTLF---YPMVSGRE- 309
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 517594622 562 qmGGTGLGLAIAKEMIEAHGGSIWAKSEEGKGT-TIYftLPM 602
Cdd:PRK11073 310 --GGTGLGLSIARNLIDQHSGKIEFTSWPGHTEfSVY--LPI 347
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
382-601 |
2.71e-19 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 92.11 E-value: 2.71e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 382 REFVANVSHELRTPLTTMRSYLEALSDGawQDPNIAPQFLTVTQEETERMIRLVNALLQLSKLDSTEHRLMKEWVDFTDF 461
Cdd:TIGR03785 486 ENMSSRLSHELRTPVAVVRSSLENLELQ--ALEQEKQKYLERAREGTERLSMILNNMSEATRLEQAIQSAEVEDFDLSEV 563
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 462 FNNVIDRFEMSKEqNVIFKRSFSKKSRFIDMDADKITQVLYNIISNALKYSPEGGTVTYRLRDREDMLEISVSDQGMGIP 541
Cdd:TIGR03785 564 LSGCMQGYQMTYP-PQRFELNIPETPLVMRGSPELIAQMLDKLVDNAREFSPEDGLIEVGLSQNKSHALLTVSNEGPPLP 642
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 517594622 542 KENVEKIFERFYRVDKARSRQMGGTGLGLAIAKEMIEAHGGSIWAKS-EEGKGTTIYFTLP 601
Cdd:TIGR03785 643 EDMGEQLFDSMVSVRDQGAQDQPHLGLGLYIVRLIADFHQGRIQAENrQQNDGVVFRISLP 703
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
499-584 |
4.25e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 82.89 E-value: 4.25e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 499 QVLYNIISNALKYSPEGGTVTYRLRDREDMLEISVSDQGMGIPKENVEKIFERFYRVDKARSRQMgGTGLGLAIAKEMIE 578
Cdd:cd16945 7 QAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQK-STGLGLAFVQEVAQ 85
|
....*.
gi 517594622 579 AHGGSI 584
Cdd:cd16945 86 LHGGRI 91
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-584 |
7.18e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 79.43 E-value: 7.18e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 493 DADKITQVLYNIISNALKYSPEGGTVTYRLRDREDMLEISVSDQGMGIPKENVEKIFERFYRVDKARsRQMGGTGLGLAI 572
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSR-RSGGHYGMGLYI 79
|
90
....*....|..
gi 517594622 573 AKEMIEAHGGSI 584
Cdd:cd16975 80 AKNLVEKHGGSL 91
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
380-603 |
9.42e-18 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 86.12 E-value: 9.42e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 380 ERREFVANVSHELRTPLTTMRSYLEALSDgawQDPNIAPQFLTvtqeETERMIRLVNALLQLSKLDSTEHRlmkEWVDFT 459
Cdd:PRK09467 228 DRTLLMAGVSHDLRTPLTRIRLATEMMSE---EDGYLAESINK----DIEECNAIIEQFIDYLRTGQEMPM---EMADLN 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 460 DFFNNVIDRfEMSKEQNVIFKrsFSKKSRFIDMDADKITQVLYNIISNALKYSpeGGTVTYRLRDREDMLEISVSDQGMG 539
Cdd:PRK09467 298 ALLGEVIAA-ESGYEREIETA--LQPGPIEVPMNPIAIKRALANLVVNAARYG--NGWIKVSSGTEGKRAWFQVEDDGPG 372
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 517594622 540 IPKENVEKIFERFYRVDKARSRQmgGTGLGLAIAKEMIEAHGGSI-WAKSEEGkGTTIYFTLPMA 603
Cdd:PRK09467 373 IPPEQLKHLFQPFTRGDSARGSS--GTGLGLAIVKRIVDQHNGKVeLGNSEEG-GLSARAWLPLT 434
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
365-602 |
1.86e-17 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 86.57 E-value: 1.86e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 365 IAVLYDVTEQERIDRERRE--------------FVANVSHELRTPLTTMRSYLEALSdgawqdpniapqfltvTQEETER 430
Cdd:PRK10841 417 ICVLVDVSARVKMEESLQEmaqaaeqasqsksmFLATVSHELRTPLYGIIGNLDLLQ----------------TKELPKG 480
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 431 MIRLVNALLQLSKLdstehrLMKEWVDFTDFfnnvidrfemSK---EQNVIFKRSFS-----------------KKSR-- 488
Cdd:PRK10841 481 VDRLVTAMNNSSSL------LLKIISDILDF----------SKiesEQLKIEPREFSprevinhitanylplvvKKRLgl 544
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 489 --FID------MDAD--KITQVLYNIISNALKYSPEGGtVTYRLRDREDMLEISVSDQGMGIPKENVEKIFERFYRVDKA 558
Cdd:PRK10841 545 ycFIEpdvpvaLNGDpmRLQQVISNLLSNAIKFTDTGC-IVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTG 623
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 517594622 559 RSRQMGGTGLGLAIAKEMIEAHGGSIWAKSEEGKGTTIYFTLPM 602
Cdd:PRK10841 624 VQRNFQGTGLGLAICEKLINMMDGDISVDSEPGMGSQFTIRIPL 667
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
380-446 |
4.92e-17 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 75.71 E-value: 4.92e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 517594622 380 ERREFVANVSHELRTPLTTMRSYLEALSDgaWQDPNIAPQFLTVTQEETERMIRLVNALLQLSKLDS 446
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRD--EKLDEEQREYLETILRSAERLLRLINDLLDLSRIEA 65
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
493-602 |
2.87e-16 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 82.59 E-value: 2.87e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 493 DADKITQVLYNIISNALKYSPEGG---TVTYRLRDREDM-LEISVSDQGMGIPKENVEKIFERFYRVDKARSRQMGGTGL 568
Cdd:PRK11107 405 DPLRLQQIITNLVGNAIKFTESGNidiLVELRALSNTKVqLEVQIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGL 484
|
90 100 110
....*....|....*....|....*....|....
gi 517594622 569 GLAIAKEMIEAHGGSIWAKSEEGKGTTIYFTLPM 602
Cdd:PRK11107 485 GLVITQKLVNEMGGDISFHSQPNRGSTFWFHLPL 518
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
378-443 |
3.11e-16 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 73.40 E-value: 3.11e-16
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 517594622 378 DRERREFVANVSHELRTPLTTMRSYLEALSDGAWQDPNIApQFLTVTQEETERMIRLVNALLQLSK 443
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQR-EYLERIREEAERLLRLINDLLDLSR 65
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
373-602 |
4.93e-16 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 81.88 E-value: 4.93e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 373 EQERIDRERREFVANVSHELRTPLTTMRSYLEALSDgawqDPNIAPQ--FLTVTQEETERMIRLVNALLQLSKLDSTEHR 450
Cdd:PRK11466 436 EAEKASQAKSAFLAAMSHEIRTPLYGILGTAQLLAD----NPALNAQrdDLRAITDSGESLLTILNDILDYSAIEAGGKN 511
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 451 lmkewVDFTDffnnviDRFEMSKEQNVIFKRSFSK-KSRFIDMDAD--------------KITQVLYNIISNALKYSpEG 515
Cdd:PRK11466 512 -----VSVSD------EPFEPRPLLESTLQLMSGRvKGRPIRLATDiaddlptalmgdprRIRQVITNLLSNALRFT-DE 579
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 516 GTVTYRLRDREDMLEISVSDQGMGIPKENVEKIFERFYRVDKARsrqmGGTGLGLAIAKEMIEAHGGSIWAKSEEGKGTT 595
Cdd:PRK11466 580 GSIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSATSTPEVGSC 655
|
....*..
gi 517594622 596 IYFTLPM 602
Cdd:PRK11466 656 FCLRLPL 662
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
380-446 |
7.94e-16 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 72.21 E-value: 7.94e-16
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 517594622 380 ERREFVANVSHELRTPLTTMRSYLEALSDGAWQDPNiaPQFLTVTQEETERMIRLVNALLQLSKLDS 446
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQ--REYLETILREAERLLRLINDLLDLSRIEA 65
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
474-584 |
1.99e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 73.44 E-value: 1.99e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 474 EQNVIFKRSFSKKSRFIdMDADKITQVLYNIISNALKYSPEGGTVTyrLRDREDMLEISVSDQGMGIPKENVEKIFERFY 553
Cdd:cd16954 16 RKGVSISLDISPELRFP-GERNDLMELLGNLLDNACKWCLEFVEVT--ARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQ 92
|
90 100 110
....*....|....*....|....*....|.
gi 517594622 554 RVDKARSrqmgGTGLGLAIAKEMIEAHGGSI 584
Cdd:cd16954 93 RLDEQRP----GQGLGLAIAKEIVEQYGGEL 119
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
372-601 |
3.92e-15 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 78.95 E-value: 3.92e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 372 TEQERIDR-----ERRE----FVANVSHELRTPLTTMRSYLEaLSDGAWQDPNIAPQFLTVTQEETERMIRLVNALLQLS 442
Cdd:PRK13837 432 TERDALERrlehaRRLEavgtLASGIAHNFNNILGAILGYAE-MALNKLARHSRAARYIDEIISAGARARLIIDQILAFG 510
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 443 -KLDSTEHRlmkewVDFTDFFNNVIDRFEMSKEQNVIFKRSFSKKSRFIDMDADKITQVLYNIISNALKYSPEGGTVTYR 521
Cdd:PRK13837 511 rKGERNTKP-----FDLSELVTEIAPLLRVSLPPGVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDIS 585
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 522 LRDRE---------------DMLEISVSDQGMGIPKENVEKIFERFYrvdKARSrqmGGTGLGLAIAKEMIEAHGGSIWA 586
Cdd:PRK13837 586 LSRAKlrapkvlshgvlppgRYVLLRVSDTGAGIDEAVLPHIFEPFF---TTRA---GGTGLGLATVHGIVSAHAGYIDV 659
|
250
....*....|....*
gi 517594622 587 KSEEGKGTTIYFTLP 601
Cdd:PRK13837 660 QSTVGRGTRFDVYLP 674
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
503-601 |
1.45e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 69.62 E-value: 1.45e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 503 NIISNALKYS----PEGGTVTYRLRDREDMLEISVSDQGMGIPKENVEKIFERFYrvdkaRSRQMGGTGLGLAIAKEMIE 578
Cdd:cd16915 7 NLIDNALDALaatgAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGV-----STKGQGERGIGLALVRQSVE 81
|
90 100
....*....|....*....|...
gi 517594622 579 AHGGSIWAKSEEGKGTTIYFTLP 601
Cdd:cd16915 82 RLGGSITVESEPGGGTTFSIRIP 104
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
493-601 |
6.64e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 67.95 E-value: 6.64e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 493 DADKITQVLYNIISNALKySPEG-----GTVTYRLR-DREDMLEISVSDQGMGIPKENVEKIFERfYRVDKARsrqmgGT 566
Cdd:cd16944 1 DTTQISQVLTNILKNAAE-AIEGrpsdvGEVRIRVEaDQDGRIVLIVCDNGKGFPREMRHRATEP-YVTTRPK-----GT 73
|
90 100 110
....*....|....*....|....*....|....*
gi 517594622 567 GLGLAIAKEMIEAHGGSIWAKSEEGKGTTIYFTLP 601
Cdd:cd16944 74 GLGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
497-600 |
8.57e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 67.48 E-value: 8.57e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 497 ITQVLYNIISNALK--YSPEGGTVTYRLRDREDMLEISVSDQGMGIPKENVEKIFERFYRvdkarSRQMG-GTGLGLAIA 573
Cdd:cd16976 1 IQQVLMNLLQNALDamGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFT-----TKPVGkGTGLGLSIS 75
|
90 100
....*....|....*....|....*..
gi 517594622 574 KEMIEAHGGSIWAKSEEGKGTTIYFTL 600
Cdd:cd16976 76 YGIVEEHGGRLSVANEEGAGARFTFDL 102
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
373-584 |
1.16e-13 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 73.51 E-value: 1.16e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 373 EQERIDRERREfVANVSHELRTPLTTMRSYLEALSDGawqdpniapQFLTVTQ------EETERMIRLVNALLQLSKLDS 446
Cdd:PRK10815 259 ERERYTKYRTT-LTDLTHSLKTPLAVLQSTLRSLRSG---------KQMSVEQaepimlEQISRISQQIGYYLHRASMRS 328
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 447 TEHRLMKEWVDFTDFFNNVIDRFemskeqNVIFKRsfskKSRFIDMD-ADKIT---------QVLYNIISNALKYSPEGG 516
Cdd:PRK10815 329 EHNLLSRELHSVAPLLDNLTSAL------NKVYQR----KGVNITLDiSPEITfvgekndfmEVMGNVLDNACKYCLEFV 398
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 517594622 517 TVTYRLRDreDMLEISVSDQGMGIPKENVEKIFERFYRVDKARSrqmgGTGLGLAIAKEMIEAHGGSI 584
Cdd:PRK10815 399 EISARQTD--EHLHIVVEDDGPGIPESKRELIFDRGQRADTLRP----GQGLGLSVAREITEQYEGKI 460
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
491-608 |
1.92e-13 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 73.02 E-value: 1.92e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 491 DMDADKITqVLYNIISNALKY--SPEGGTVTYRLRDREDMLEISVSDQGMGIPKENVEKIFERFYrvdkarSRQMGGTGL 568
Cdd:PRK11086 429 DQVHELIT-ILGNLIENALEAvgGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGY------STKGSNRGV 501
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 517594622 569 GLAIAKEMIEAHGGSIWAKSEEGKGTTIYFTLPMAKEEED 608
Cdd:PRK11086 502 GLYLVKQSVENLGGSIAVESEPGVGTQFFVQIPWDGERSN 541
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
2-608 |
2.34e-13 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 72.94 E-value: 2.34e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 2 KKVGFFQsiHLKFVLIYMLLILiamqVIGVYFVRELEKSLVQSFKDSLTQQTNLLSYNLKQEFA---------KEREKTD 72
Cdd:PRK15053 8 KQFAFFQ--RLAFPLRIFLLIL----VFSIFVIAALAQYFSASFEDYLTLHVRDMAMNQAKIIAsndsvisavKTRDYKR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 73 PPLENAIKTSITDFASDRKKDIQEVRVIDPNRRLLAISNS-SKQGMVGKTITDItvqraivqkkaegkIEKDGKTGHRVQ 151
Cdd:PRK15053 82 LATIANKLQRDTDFDYVVIGDRHSIRLYHPNPEKIGYPMQfTKPGALEKGESYF--------------ITGKGSMGMAMR 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 152 VmATPIEGEKGKIIGVIHIVASMEDVYKQMKDINQIFATGTVIALLVTAVLGILLAQTItrpisdmRRQAIEMAKGNYSR 231
Cdd:PRK15053 148 A-KTPIFDDDGKVIGVVSIGYLVSKIDSWRLEFLLPMAGVFVVLLGILMLLSWFFAAHI-------RRQMMGMEPKQIAR 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 232 KVkvhshdeigqlalafnnlskklqqarssteserRKLSSVLSHMTDGVIATDRKGDIILLNDPAEKMLNVSR--ETALN 309
Cdd:PRK15053 220 VV---------------------------------RQQEALFSSVYEGLIAVDPHGYITAINRNARKMLGLSSpgRQWLG 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 310 QSVLEVLGIQEEFTlDHLYEEPDSVLLDFStrnepyilraSFSVIQKETG--KANGLIAVLYDVTEQERIdrerrefvan 387
Cdd:PRK15053 267 KPIAEVVRPADFFT-EQIDEKRQDVVANFN----------GLSVIANREAirSGDDLLGAIISFRSKDEI---------- 325
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 388 vsHELRTPLTTMRSYLEALSdgawqdpniapqflTVTQEETERMIRLvNALLQLSKLD------STEHRLMKEWVDF--T 459
Cdd:PRK15053 326 --STLNAQLTQIKQYVESLR--------------TLRHEHLNWMSTL-NGLLQMKEYDrvlemvQGESQAQQQLIDSlrE 388
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 460 DFFNNVIDRFEMSKEQNVifkRSFSKKSRFID----------MDADKITQVLYNIISNALKYS---PEGG-TVTYRLRDR 525
Cdd:PRK15053 389 AFADRQVAGLLFGKVQRA---RELGLKMVIVPgsqlsqlppgLDSTEFAAIVGNLLDNAFEASlrsDEGNkIVELFLSDE 465
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 526 EDMLEISVSDQGMGIPKENVEKIFERFYrvdKARSRQMGGTGLGLAIAKEMIEAHGGSIWAKSEEGKGTTIYFTLPMAKE 605
Cdd:PRK15053 466 GDDVVIEVADQGCGVPESLRDKIFEQGV---STRADEPGEHGIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFIPKVKP 542
|
...
gi 517594622 606 EED 608
Cdd:PRK15053 543 NDS 545
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
499-601 |
4.12e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 65.86 E-value: 4.12e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 499 QVLYNIISNALKYSPEGGTVTYRLRDRE---------------DMLEISVSDQGMGIPKENVEKIFERFYRvdkarSRQM 563
Cdd:cd16919 3 LAILNLAVNARDAMPEGGRLTIETSNQRvdadyalnyrdlipgNYVCLEVSDTGSGMPAEVLRRAFEPFFT-----TKEV 77
|
90 100 110
....*....|....*....|....*....|....*....
gi 517594622 564 G-GTGLGLAIAKEMIEAHGGSIWAKSEEGKGTTIYFTLP 601
Cdd:cd16919 78 GkGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
211-255 |
5.81e-13 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 63.23 E-value: 5.81e-13
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 517594622 211 TRPISDMRRQAIEMAKGNYSRKVKVHSHDEIGQLALAFNNLSKKL 255
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
501-601 |
1.07e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 61.03 E-value: 1.07e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 501 LYNII----SNALKYSPeGGTVTYRLRDREDMLEISVSDQGMGIPKENVEkiferfyrvdkarsrqmGGTGLGLAIAKEM 576
Cdd:cd16917 1 LYRIVqealTNALKHAG-ASRVRVTLSYTADELTLTVVDDGVGFDGPAPP-----------------GGGGFGLLGMRER 62
|
90 100
....*....|....*....|....*
gi 517594622 577 IEAHGGSIWAKSEEGKGTTIYFTLP 601
Cdd:cd16917 63 AELLGGTLTIGSRPGGGTRVTARLP 87
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
12-280 |
1.33e-11 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 67.35 E-value: 1.33e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 12 LKFVLIYMLLILIAMQVIGVYFVRELEKSLVQSFKDSLTQQTNLLSYNLKQEFAKEREKTDPPLENAIKTSITDFASDRK 91
Cdd:COG0840 8 LALLLALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 92 KDIQEVRVIDPNRRLLAISNSSKQGMVGKTITDITVQRAIVQKKAEGKIEKDGKTGHRVQVMATPIEGEKGKIIGVIHIV 171
Cdd:COG0840 88 LLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 172 ASMEDVYKQMKDINQIFATGTVIALLVTAVLGILLAQTITRPISDMRRQAIEMAKGNYSRKVKVHSHDEIGQLALAFNNL 251
Cdd:COG0840 168 EAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRM 247
|
250 260
....*....|....*....|....*....
gi 517594622 252 SKKLQQARSSTESERRKLSSVLSHMTDGV 280
Cdd:COG0840 248 IENLRELVGQVRESAEQVASASEELAASA 276
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
497-601 |
2.88e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 60.49 E-value: 2.88e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 497 ITQVLYNIISNALK-YSPEGGTVTYRLRDREDM----------LEISVSDQGMGIPKENVEKIFERFYrvdkarSRQMGG 565
Cdd:cd16918 1 LIQVFLNLVRNAAQaLAGSGGEIILRTRTQRQVtlghprhrlaLRVSVIDNGPGIPPDLQDTIFYPMV------SGRENG 74
|
90 100 110
....*....|....*....|....*....|....*.
gi 517594622 566 TGLGLAIAKEMIEAHGGSIWAKSEEGKgTTIYFTLP 601
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
|
|
| HAMP |
pfam00672 |
HAMP domain; |
205-257 |
2.91e-11 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 58.79 E-value: 2.91e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 517594622 205 LLAQTITRPISDMRRQAIEMAKGNYSRKVKVHSHDEIGQLALAFNNLSKKLQQ 257
Cdd:pfam00672 1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
186-406 |
2.47e-10 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 62.98 E-value: 2.47e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 186 QIFATGTVIALLVTAVLGILLAQTITRPISDMRRQAIEMAKGNYSRKVKVHSHDEIGQLALAFNNLSKKLQQARSSTESE 265
Cdd:COG3850 118 KLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFNRMADELQELYAELEEE 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 266 R--RKLSSVLSHMTDGVIATDRKGDIILLNDPAEKMLNVSRETALNQSVLEVLGIQEEFTLDHLYEEPDSVLLDFSTRNE 343
Cdd:COG3850 198 EelEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELLALNILAGLLELLLALLLLLLASA 277
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 517594622 344 PYILRASFSVIQKETGKANGLIAVLYDVTEQERIDRERREFVANVSHELRTPLTTMRSYLEAL 406
Cdd:COG3850 278 LLLLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQAIANASLLLIALASVVAAL 340
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
12-388 |
2.92e-10 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 63.21 E-value: 2.92e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 12 LKFVLIYMLLILIAMQVIGVYFVRELEKSLVQSFKDSLTQQTNLLSYNLKQEFAKEREKTDPPLENAIKTSITDFASDRK 91
Cdd:COG2770 37 LALLLLLLLLLALLLLLLLLLLLLLAALVLLALLLAAALLLLLLLLSLVALAALLLALLLLLLLALLLLLAALLLLLLLA 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 92 KDIQEVRVIDPNRRLLAISNSSKQGMVGKTITDITVQRAIVQKKAEGKI-EKDGKTGHRVQVMATPIEGEKGKIIGVIHI 170
Cdd:COG2770 117 ALALLLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAALAlALGAGELLLLADLAAAIAALLAALLLLLLG 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 171 VASMEDVYKQMKDINQIFATGTVIALLVTAVLGILLAQTITRPISDMRRQAIEMAKGNYSRKVKVHSHDEIGQLALAFNN 250
Cdd:COG2770 197 GLLLVVLLEAALAALLLLLLLALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNR 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 251 LSKKLQQARSSTESERRKLSSVLSHMTDGVIATDRKGDIILLNDPAEKMLNVSRETALNQSVLEVLGIQEEFTLDHLYEE 330
Cdd:COG2770 277 MADSLRESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALAL 356
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 517594622 331 PDSVLLDFSTRNEPYILRASFSVIQKETGKANGLIAVLYDVTEQERIDRERREFVANV 388
Cdd:COG2770 357 AALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVL 414
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
388-584 |
5.17e-10 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 62.40 E-value: 5.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 388 VSHELRTPLTTMRSYL-EALSDGAWQDPNIAPQFLTVTQEETERMIRLVNALLQLSKLDSTEHRLmkewVDFTDFFNNVI 466
Cdd:COG4192 440 LAHELNQPLNAMSMYLfSAKKALEQENYAQLPTSLDKIEGLIERMDKIIKSLRQFSRKSDTPLQP----VDLRQVIEQAW 515
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 467 DRFEM--SKEQNVIFKRSFSkksrFIDMDADKITQVLYNIISNALKYSPEGGTVTYRLRDREDMLEISVSDQGMGIPkeN 544
Cdd:COG4192 516 ELVESraKPQQITLHIPDDL----MVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGWP--L 589
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 517594622 545 VEKIFERFYrvdkarSRQMGGTGLGLAIAKEMIEAHGGSI 584
Cdd:COG4192 590 VDKLFTPFT------TTKEVGLGLGLSICRSIMQQFGGDL 623
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
209-260 |
5.29e-10 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 55.33 E-value: 5.29e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 517594622 209 TITRPISDMRRQAIEMAKGNYSRKVKVHSHDEIGQLALAFNNLSKKLQQARS 260
Cdd:smart00304 2 RLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
373-605 |
5.36e-10 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 60.40 E-value: 5.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 373 EQERIDRERREFVA----NVSHELrtplTTMRSYLEALSDGAWQDPNIAPQFLTVTQEETERMIRLVNALLqlskldste 448
Cdd:COG4585 46 AEEAREEERRRIARelhdGVGQSL----SAIKLQLEAARRLLDADPEAAREELEEIRELAREALAELRRLV--------- 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 449 HRLM---KEWVDFTDFFNNVIDRFEMSKEQNVIFkrSFSKKSRFIDMDADkitQVLYNI----ISNALKYSPeGGTVTYR 521
Cdd:COG4585 113 RGLRppaLDDLGLAAALEELAERLLRAAGIRVEL--DVDGDPDRLPPEVE---LALYRIvqeaLTNALKHAG-ATRVTVT 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 522 LRDREDMLEISVSDQGMGIPKEnvekiferfyrvdkarsrQMGGTGLGLAIAKEMIEAHGGSIWAKSEEGKGTTIYFTLP 601
Cdd:COG4585 187 LEVDDGELTLTVRDDGVGFDPE------------------AAPGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLP 248
|
....
gi 517594622 602 MAKE 605
Cdd:COG4585 249 LAAA 252
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
504-605 |
7.98e-10 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 61.19 E-value: 7.98e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 504 IISNALKY----SPEGGTVTYRLRDREDMLEISVSDQGMGIPKENVEKIFERFyrvdkarSRQMGGTGLGLAIAKEMIEA 579
Cdd:COG2972 344 LVENAIEHgiepKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-------SSKGEGRGIGLRNVRERLKL 416
|
90 100
....*....|....*....|....*....
gi 517594622 580 H---GGSIWAKSEEGKGTTIYFTLPMAKE 605
Cdd:COG2972 417 YygeEYGLEIESEPGEGTTVTIRIPLEEE 445
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
501-609 |
2.39e-09 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 60.07 E-value: 2.39e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 501 LYNIISNALKYSPEGGTVTYRLR----DREDMLE-----------ISVSDQGMGIPKENVEKIFERFYRvdkarSRQMG- 564
Cdd:PRK13557 282 LLNVLINARDAMPEGGRVTIRTRnveiEDEDLAMyhglppgryvsIAVTDTGSGMPPEILARVMDPFFT-----TKEEGk 356
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 517594622 565 GTGLGLAIAKEMIEAHGGSIWAKSEEGKGTTIYFTLPMAKEEEDD 609
Cdd:PRK13557 357 GTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFPASDQAENP 401
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
261-383 |
2.76e-09 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 59.78 E-value: 2.76e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 261 STESERRKLSSVLSHMTDGVIATDRKGDIILLNDPAEKMLNVSRETALNQSVLEVLgiqEEFTLDHLYEEPDSVLLDF-S 339
Cdd:COG3829 5 ELKELEEELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVTELI---PNSPLLEVLKTGKPVTGVIqK 81
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 517594622 340 TRNEPYILRASFSVIqKETGKANGLIAVLYDVTEQERIDRERRE 383
Cdd:COG3829 82 TGGKGKTVIVTAIPI-FEDGEVIGAVETFRDITELKRLERKLRE 124
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
257-411 |
7.49e-09 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 56.96 E-value: 7.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 257 QARSSTESERRKLSSVLSHMTDGVIATDRKGDIILLNDPAEKMLNVSRETALNQSVLEVLGIQEEftlDHLYEEPDSVLL 336
Cdd:COG2202 1 TAEEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLPPEDD---DEFLELLRAALA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 337 -----DFSTRN-----EPYILRASFSVIQKETGKANGLIAVLYDVTEQERIDRERREfvanvSHELrtplttMRSYLEAL 406
Cdd:COG2202 78 gggvwRGELRNrrkdgSLFWVELSISPVRDEDGEITGFVGIARDITERKRAEEALRE-----SEER------LRLLVENA 146
|
....*
gi 517594622 407 SDGAW 411
Cdd:COG2202 147 PDGIF 151
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
513-601 |
8.52e-08 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 52.58 E-value: 8.52e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 513 PEGGTVTYRLRDREDMLEISVSDQGMGIPKENV-EKIFERFYRVDKARSR----------------------QMGGTGLG 569
Cdd:cd16916 67 PPEGTITLRAEHQGNQVVIEVSDDGRGIDREKIrEKAIERGLITADEAATlsddevlnlifapgfstaeqvtDVSGRGVG 146
|
90 100 110
....*....|....*....|....*....|..
gi 517594622 570 LAIAKEMIEAHGGSIWAKSEEGKGTTIYFTLP 601
Cdd:cd16916 147 MDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
456-607 |
8.54e-08 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 54.91 E-value: 8.54e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 456 VDFTDFFNNVIDRFEMSKEQNVIfkrSFSKKSRFIDMDADKITQ---VLYNIISNALKY---SPEGGTVTYRLRDREDML 529
Cdd:COG3920 359 VDLRDYLRELLEPLRDSYGGRGI---RIELDGPDVELPADAAVPlglILNELVTNALKHaflSGEGGRIRVSWRREDGRL 435
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 517594622 530 EISVSDQGMGIPKEnvekiferfyrVDKARSRqmggtGLGLAIAKEMIEAHGGSIwaKSEEGKGTTIYFTLPMAKEEE 607
Cdd:COG3920 436 RLTVSDNGVGLPED-----------VDPPARK-----GLGLRLIRALVRQLGGTL--ELDRPEGTRVRITFPLAELAA 495
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
481-601 |
2.75e-07 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 49.53 E-value: 2.75e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 481 RSFSKKSRFIDMDADKITQVLYNIISNALKYS---PEGGTVTYRLRDREDMLEISVSDQGMGIPKENVEKIFErfyrvdk 557
Cdd:COG2172 19 RALLRELGLDEDDADDLVLAVSEAVTNAVRHAyggDPDGPVEVELELDPDGLEIEVRDEGPGFDPEDLPDPYS------- 91
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 517594622 558 arsrQMGGTGLGLAIAKEMIEahggSIWAKSEEGkGTTIYFTLP 601
Cdd:COG2172 92 ----TLAEGGRGLFLIRRLMD----EVEYESDPG-GTTVRLVKR 126
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
267-316 |
5.62e-07 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 47.01 E-value: 5.62e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 517594622 267 RKLSSVLSHMTDGVIATDRKGDIILLNDPAEKMLNVSRETALNQSVLEVL 316
Cdd:smart00091 1 ERLRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELI 50
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
513-601 |
6.26e-07 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 52.49 E-value: 6.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 513 PEGGTVTYRLRDREDMLEISVSDQGMGIpkeNVEKIFErfyrvdKARSR---------QMG------------------- 564
Cdd:COG0643 306 PETGTITLSAYHEGGRVVIEVSDDGRGL---DLEKIRA------KAIEKglitaeeaaALSdeellelifapgfstaeev 376
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 517594622 565 ----GTGLGLAIAKEMIEAHGGSIWAKSEEGKGTTIYFTLP 601
Cdd:COG0643 377 tdlsGRGVGMDVVKTNIEALGGTIEIESEPGKGTTFTLRLP 417
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
267-371 |
7.96e-07 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 48.18 E-value: 7.96e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 267 RKLSSVLSHMTDGVIATDRKGDIILLNDPAEKMLNVSRETALNQSVLEVL-GIQEEFTLDHL------YEEPDSVLLDF- 338
Cdd:pfam00989 1 EDLRAILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIpEEDDAEVAELLrqallqGEESRGFEVSFr 80
|
90 100 110
....*....|....*....|....*....|...
gi 517594622 339 STRNEPYILRASFSVIQKETGKANGLIAVLYDV 371
Cdd:pfam00989 81 VPDGRPRHVEVRASPVRDAGGEILGFLGVLRDI 113
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
276-371 |
4.76e-06 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 45.70 E-value: 4.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 276 MTDGVIATDRKGDIILLNDPAEKMLNVSRETALNQSVLEVLGIQEEF----TLDHLYEEPDSVLLDFSTRN---EPYILR 348
Cdd:cd00130 1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREelreRLENLLSGGEPVTLEVRLRRkdgSVIWVL 80
|
90 100
....*....|....*....|...
gi 517594622 349 ASFSVIQKETGKANGLIAVLYDV 371
Cdd:cd00130 81 VSLTPIRDEGGEVIGLLGVVRDI 103
|
|
| HATPase_PDK-like |
cd16929 |
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ... |
524-601 |
6.81e-06 |
|
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.
Pssm-ID: 340406 [Multi-domain] Cd Length: 169 Bit Score: 46.56 E-value: 6.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 524 DREDMLeISVSDQGMGIPKENVEKIFERFY----------RVDKARSRQ---MGGTGLGLAIAKEMIEAHGGSIWAKSEE 590
Cdd:cd16929 80 GDEDLT-IKISDRGGGIPREDLARLFSYMYstapqpslddFSDLISGTQpspLAGFGYGLPMSRLYAEYFGGDLDLQSME 158
|
90
....*....|.
gi 517594622 591 GKGTTIYFTLP 601
Cdd:cd16929 159 GYGTDVYIYLK 169
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
499-601 |
1.93e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 43.95 E-value: 1.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 499 QVLY-NIISNALKYSPEGGTVTYRLRDREDMLEISVSDQGMGIPKENVEKIFERFYRVDKarsrqmgGTGLGLA-IAKEM 576
Cdd:cd16957 7 QVLVeNAIRHAFPKRKENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGKTTVTSEK-------GTGTALEnLNRRL 79
|
90 100
....*....|....*....|....*..
gi 517594622 577 IEAHG--GSIWAKSEEGKGTTIYFTLP 601
Cdd:cd16957 80 IGLFGseACLHIESEVHGGTEVWFVIP 106
|
|
| HATPase_EL346-LOV-HK-like |
cd16951 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
486-601 |
2.64e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.
Pssm-ID: 340427 [Multi-domain] Cd Length: 131 Bit Score: 43.95 E-value: 2.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 486 KSRFIDMDADKITQ---VLYNIISNALKYS---PEGGTVTYRLRDREDMLEISVSDQGMGIPKENvekiferfyrvDKAR 559
Cdd:cd16951 26 TGDTGPVSSEVATAiglVVNELLQNALKHAfsdREGGTITIRSVVDGDYLRITVIDDGVGLPQDE-----------DWPN 94
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 517594622 560 SrqmggTGLGLAIAKEMIEAHGGSIWAKSEEGKGTTIYFTLP 601
Cdd:cd16951 95 K-----GSLGLQIVRSLVEGELKAFLEVQSAENGTRVNIDIP 131
|
|
| PAS_9 |
pfam13426 |
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ... |
286-373 |
6.70e-05 |
|
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463873 [Multi-domain] Cd Length: 93 Bit Score: 42.06 E-value: 6.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 286 KGDIILLNDPAEKMLNVSRETALNQSVLEVLGIQEEF-TLDHLYEE---PDSVLLDFSTRN-EPYILRASFSVIQKETGK 360
Cdd:pfam13426 1 DGRIIYVNDAALRLLGYTREELLGKSITDLFAEPEDSeRLREALREgkaVREFEVVLYRKDgEPFPVLVSLAPIRDDGGE 80
|
90
....*....|...
gi 517594622 361 ANGLIAVLYDVTE 373
Cdd:pfam13426 81 LVGIIAILRDITE 93
|
|
| PAS_4 |
pfam08448 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
273-376 |
1.07e-04 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain is associated to signalling systems and works as a signal sensor domain. It recognizes differently substituted aromatic hydrocarbons, oxygen, different dodecanoic acids, autoinducers, 3,5-dimethyl-pyrazin-2-ol and N-alanyl-aminoacetone (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 312075 [Multi-domain] Cd Length: 110 Bit Score: 42.02 E-value: 1.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 273 LSHMTDGVIATDRKGDIILLNDPAEKMLNVSRETALNQSVLEVL--GIQEEFT--LDHLYEEPDSV-LLDFSTRN-EPYI 346
Cdd:pfam08448 1 LDSLPDALAVLDPDGRVRYANAAAAELFGLPPEELLGKTLAELLppEDAARLEraLRRALEGEEPIdFLEELLLNgEERH 80
|
90 100 110
....*....|....*....|....*....|
gi 517594622 347 LRASFSVIQKETGKANGLIAVLYDVTEQER 376
Cdd:pfam08448 81 YELRLTPLRDPDGEVIGVLVISRDITERRR 110
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
253-381 |
1.41e-04 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 43.86 E-value: 1.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 253 KKLQQARSstESERRkLSSVLSHMTDGVIATDRKGDIILLNDPAEKMLNVSRETALNQSVLEVLGIQEEFTLDHLYEE-- 330
Cdd:COG2202 126 KRAEEALR--ESEER-LRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKSLLDLLHPEDRERLLELLRRll 202
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 517594622 331 ---PDSVLLDFSTRN---EPYILRASFSVIQKEtGKANGLIAVLYDVTEQERIDRER 381
Cdd:COG2202 203 eggRESYELELRLKDgdgRWVWVEASAVPLRDG-GEVIGVLGIVRDITERKRAEEAL 258
|
|
| ArlS_N |
pfam18719 |
ArlS sensor domain; This entry represents the N-terminal extracellular sensor domain of the ... |
37-182 |
1.07e-03 |
|
ArlS sensor domain; This entry represents the N-terminal extracellular sensor domain of the ArlS protein from S. aureus. It recognizes LL-37 antimicrobial peptide (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 465847 Cd Length: 127 Bit Score: 39.30 E-value: 1.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 37 LEKSLVQSFKDSLTQQTNLLSYNLKQefakerekTDPPLENAIKTSITDFASDRKKDiQEVRVIDPNRRLLAISNSSKQG 116
Cdd:pfam18719 1 FSNWLLDQEKQNVNETMTEVSERLSE--------IDTELDQESIYSDSLLQSLSRKN-QTIRIYDPDGKLLFSSRNDPVP 71
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 517594622 117 MVGKTITDITVQRAIVQKKaegkiekdgktGHRVQVMATPIEGEKGKIIGVIHIVASMEDVYKQMK 182
Cdd:pfam18719 72 FKPPKKVKSEETRKISLVK-----------GKRVLVGRSPIYSKNGLIIGYVQVVNSLESYDSLMN 126
|
|
| PRK09776 |
PRK09776 |
putative diguanylate cyclase; Provisional |
265-380 |
1.27e-03 |
|
putative diguanylate cyclase; Provisional
Pssm-ID: 182070 [Multi-domain] Cd Length: 1092 Bit Score: 41.97 E-value: 1.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 265 ERRKLSSVLSHMTDGVIATDRKGDIILLNDPAEKMLNVSRETALNQSVLEVLGIQEEFTLDHLyeepDSVLLDFSTRNEP 344
Cdd:PRK09776 534 EKERLHITLDSIGEAVVCTDMAMKVTFMNPVAEKMTGWTQEEALGVPLLTVLHITFGDNGPLM----ENIYSCLTSRSAA 609
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 517594622 345 YI---------------LRASFSVIQKETGKANGLIAVLYDVTEQERIDRE 380
Cdd:PRK09776 610 YLeqdvvlhcrsggsydVHYSITPLSTLDGENIGSVLVIQDVTESRKMLRQ 660
|
|
| HATPase_ETR2_ERS2-EIN4-like |
cd16938 |
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related ... |
493-600 |
1.33e-03 |
|
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related domains; This family includes the histidine kinase-like ATPase domains (HATPase) of three out of the five receptors that recognize the plant hormone ethylene in Arabidopsis thaliana. These three proteins have been classified as belonging to subfamily 2: ETR2, ERS2, and EIN4. They lack most of the motifs characteristic of histidine kinases, and EIN4 is the only one in this group containing the conserved histidine that is phosphorylated in two-component and phosphorelay systems. This family also includes the HATPase domains of Escherichia coli RcsD phosphotransferase which is a component of the Rcs-signaling system, a complex multistep phosphorelay involving five proteins, and is involved in many transcriptional networks such as cell division, biofilm formation, and virulence, among others. Also included is Schizosaccharomyces pombe Mak3 (Phk1) which participates in a multi-step two-component related system which regulates H2O2-induced activation of the Sty1 stress-activated protein kinase pathway. Most proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a GAF sensor domain; most are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340415 [Multi-domain] Cd Length: 133 Bit Score: 39.36 E-value: 1.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 493 DADKITQVLYNIISNALKYSPEGGTVTYRLR------DREDMLEI----SVSDQGMGIpKENVEKIFERFYRVDKARSRQ 562
Cdd:cd16938 8 DERRVFQVLLHMLGNLLKMRNGGGNITFRVFleggseDRSDRDWGpwrpSMSDESVEI-RFEVEINDSGSPSIESASMRN 86
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 517594622 563 ---------MGGTGLGLAIAKEMIEAHGGSIWAKSEEGKGTTIYFTL 600
Cdd:cd16938 87 slnrrynlsELGEHLSFSICKQLVQLMGGNIWIVPGSGLGTTMSLLL 133
|
|
| HATPase_RsbT-like |
cd16934 |
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine ... |
493-596 |
2.10e-03 |
|
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.
Pssm-ID: 340411 [Multi-domain] Cd Length: 117 Bit Score: 38.51 E-value: 2.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 493 DADKITQVLYNIISNALKYSpEGGTVTYRLRDREDM--LEISVSDQGMGIPkenvekiferfyRVDKARSRQM---GGTG 567
Cdd:cd16934 22 RQAEIATAVTELARNLLKHA-GGGQVLLEVVAEGGRvaLEILAVDQGPGIA------------DVDEALRDGFstgGGLG 88
|
90 100
....*....|....*....|....*....
gi 517594622 568 LGLAIAKEMieAHGGSIwaKSEEGKGTTI 596
Cdd:cd16934 89 LGLGGVRRL--ADEFDL--HSAPGRGTVV 113
|
|
| PRK10600 |
PRK10600 |
nitrate/nitrite two-component system sensor histidine kinase NarX; |
184-267 |
3.53e-03 |
|
nitrate/nitrite two-component system sensor histidine kinase NarX;
Pssm-ID: 182581 [Multi-domain] Cd Length: 569 Bit Score: 40.42 E-value: 3.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 184 INQIFATGTVIALLVTAvlgILLAQTITRPIsdmrRQAIEMA----KGNYSRKVKVHSHDEIGQLALAFNNLSKKLqqAR 259
Cdd:PRK10600 126 VHRVFAVFMALLLVFTI---IWLRRRLLQPW----RQLLSMAnavsHRDFTQRANISGRDEMAMLGTALNNMSAEL--AE 196
|
....*...
gi 517594622 260 SSTESERR 267
Cdd:PRK10600 197 SYAVLEQR 204
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
505-600 |
3.68e-03 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 36.86 E-value: 3.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 505 ISNALKY---SPEGGTVTYRLRDREDMLEISVSDQGMGIPkenvekiferfYRVDKARSRQMGGTGLGLAIAKEMIEAhg 581
Cdd:cd16936 9 VTNAVRHayrHDGPGPVRLELDLDPDRLRVEVTDSGPGFD-----------PLRPADPDAGLREGGRGLALIRALMDE-- 75
|
90
....*....|....*....
gi 517594622 582 gsiWAKSEEGKGTTIYFTL 600
Cdd:cd16936 76 ---VGYRRTPGGKTVWLEL 91
|
|
| dCache_1 |
pfam02743 |
Cache domain; Double cache domain 1 covers the last three strands from the membrane distal ... |
39-229 |
4.40e-03 |
|
Cache domain; Double cache domain 1 covers the last three strands from the membrane distal PAS-like domain, the first two strands of the membrane proximal domain, and the connecting elements between the two domains. This domain when present in chemoreceptors recognize several signals such as proteinogenic amino acids, GABA, Histamine and polyamines, decanoic acid, Autoinducer-2, purine derivatives, quaternary amines, citrate and taurine, among others. When associated with histidine kinases, it recognizes C3/C4-dicarboxylic acids, Spermine, guanosine and Autoinducer-2 (Mantilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1 https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 460673 [Multi-domain] Cd Length: 237 Bit Score: 39.24 E-value: 4.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 39 KSLVQSFKDSLTQQTNLLSYNLKQEFAKERE------------KTDPPLENAIKTSITDFASDRKkDIQEVRVIDPNRRL 106
Cdd:pfam02743 1 KAIKEQAEEQLLSLAKQLAENIESYLDSLEEilellasnpdlqDLLSAPAEEELAKLESLLRSNP-GISSIYLVDADGRV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 107 LAISNSSKQGmvgkTITDITVQRAIVQKKAEGK--------IEKDGKTGHRVQVMATPIEGEKGKIIGVIHIVASMEDVY 178
Cdd:pfam02743 80 LASSDESPSY----PGLDVSERPWYKEALKGGGgiiwvfssPYPSSESGEPVLTIARPIYDDDGEVIGVLVADLDLDTLQ 155
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 517594622 179 KQMKDINQifaTGTVIALLVTAvLGILLAQTITRPISDMRRQAIEMAKGNY 229
Cdd:pfam02743 156 ELLSQIKL---GEGGYVFIVDS-DGRILAHPLGKNLRSLLAPFLGKSLADA 202
|
|
| UhpB |
COG3851 |
Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction ... |
495-601 |
4.68e-03 |
|
Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction mechanisms];
Pssm-ID: 443060 [Multi-domain] Cd Length: 493 Bit Score: 39.99 E-value: 4.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 495 DKITQVLYNII----SNALKYSpEGGTVTYRLRDREDMLEISVSDQGMGIPkenvekiferfyrvdkARSRQmggTGLGL 570
Cdd:COG3851 395 DTLQLTLYRLVqealTNILKHA-EASQIRISLSQDKRLLSLEIRDDGIGLP----------------PELRA---KGFGL 454
|
90 100 110
....*....|....*....|....*....|.
gi 517594622 571 AIAKEMIEAHGGSiWAKSEEGKGTTIYFTLP 601
Cdd:COG3851 455 RGMRERVRALGGD-FRLSSAPKGTRLSVLLP 484
|
|
| PAS_8 |
pfam13188 |
PAS domain; PAS domains are involved in many signalling proteins where they are used as a ... |
267-316 |
5.02e-03 |
|
PAS domain; PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. This domain recognizes oxygen and CO (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463802 [Multi-domain] Cd Length: 65 Bit Score: 35.99 E-value: 5.02e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 517594622 267 RKLSSVLSHMTDGVIATDRKGDIILLNDPAEKMLNVSRETALNQSVLEVL 316
Cdd:pfam13188 1 ERLRALFESSPDGILVLDEGGRIIYVNPAALELLGYELLGELLGELLDLL 50
|
|
| PDC1_HK_sensor |
cd18773 |
first PDC (PhoQ/DcuS/CitA) domain of methyl-accepting chemotaxis proteins, diguanylate-cyclase ... |
89-168 |
7.93e-03 |
|
first PDC (PhoQ/DcuS/CitA) domain of methyl-accepting chemotaxis proteins, diguanylate-cyclase and similar domains; Histidine kinase (HK) receptors are part of two-component systems (TCS) in bacteria that play a critical role for sensing and adapting to environmental changes. Typically, HK receptors contain an extracellular sensing domain flanked by two transmembrane helices, an intracellular dimerization histidine phosphorylation domain (DHp), and a C-terminal kinase domain, with many variations on this theme. HK receptors in this family contain double PDC (PhoQ/DcuS/CitA) sensor domains. Signals detected by the sensor domain are transmitted through DHp to the kinase domain, resulting in the phosphorylation of a conserved histidine residue in DHp; phosphotransfer to a conserved aspartate in its cognate response regulator (RR) follows, which leads to the activation of genes for downstream cellular responses. The HK family includes not just histidine kinase receptors but also sensors for chemotaxis proteins and diguanylate cyclase receptors, implying a combinatorial molecular evolution.
Pssm-ID: 350341 [Multi-domain] Cd Length: 125 Bit Score: 36.77 E-value: 7.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 89 DRKKDIQEVRVIDPNRRLLAISNSSKQGMVGKTITDITVQRAIVQKKAE--GKIEKDGKTGHRVQVMATPIEGEKGKIIG 166
Cdd:cd18773 38 ERNPEISGIYVVDADGRVVASSDRDPGGGDDDDDRDRFWYQAAKATGKLviSEPYISRVTGKPVITLSRPIRDADGRFIG 117
|
..
gi 517594622 167 VI 168
Cdd:cd18773 118 VV 119
|
|
| HATPase_SpoIIAB-like |
cd16942 |
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein ... |
497-599 |
8.31e-03 |
|
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of SpoIIAB, an anti sigma-F factor and a serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli where, early in sporulation, the cell divides into two unequal compartments: a larger mother cell and a smaller forespore. Sigma-F transcription factor is activated in the forespore directly after the asymmetric septum forms, and its spatial and temporal activation is required for sporulation. Free sigma-F can associate with the RNA polymerase core and activate transcription of the sigma-F regulon, its regulation may comprise a partner-switching mechanism involving SpoIIAB, SpoIIAA, and sigma-F as follows: SpoIIAB can form alternative complexes with either: i) sigma-F, holding it in an inactive form and preventing its association with RNA polymerase, or ii) unphosphorylated SpoIIAA and a nucleotide, either ATP or ADP. In the presence of ATP, SpoIIAB acts as a kinase to specifically phosphorylate a serine residue of SpoIIAA; this phosphorylated form has low affinity for SpoIIAB and dissociates, making SpoIIAB available to capture sigma-F. SpoIIAA may then be dephosphorylated by a SpoIIE serine phosphatase and be free to attack the SpoIIAB sigma-F complex to induce the release of sigma-F.
Pssm-ID: 340418 [Multi-domain] Cd Length: 135 Bit Score: 37.13 E-value: 8.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517594622 497 ITQVLYNIISNALKYS---PEGGTVTYRLRDREDMLEISVSDQGMGIpkENVEKIFERFYRVDKARSRqmggTGLGLAIa 573
Cdd:cd16942 39 IKTVVSEAVTNAIIHGynnDPNGIVSISVIIEDGVVHLTVRDEGVGI--PDIEEARQPLFTTKPELER----SGMGFTI- 111
|
90 100
....*....|....*....|....*.
gi 517594622 574 kemIEAHGGSIWAKSEEGKGTTIYFT 599
Cdd:cd16942 112 ---MENFMDEVIVESEVNKGTTVYLK 134
|
|
| |
