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Conserved domains on  [gi|517263025|ref|WP_018451843|]
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MULTISPECIES: PH domain-containing protein [Phocaeicola]

Protein Classification

PH domain-containing protein( domain architecture ID 141072)

bacterial Pleckstrin homology (bPH) domain-containing protein may be involved in protein-protein interactions; similar to Mycobacterium tuberculosis low molecular weight protein antigen 6 (CFP-6)

CATH:  2.30.29.50
Gene Ontology:  GO:0005515
PubMed:  15493994|22728242|19913036|17233582
SCOP:  4002395

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
bPH_4 super family cl19751
Bacterial PH domain; This family consists of several hypothetical proteins specific to ...
 55-130 1.48e-09

Bacterial PH domain; This family consists of several hypothetical proteins specific to Oceanobacillus and Bacillus species. Members of this family are typically around 130 residues in length. The function of this family is unknown. Members of this family have a PH domain like structure.


The actual alignment was detected with superfamily member pfam06713:

Pssm-ID: 388627  Cd Length: 74  Bit Score: 51.07  E-value: 1.48e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 517263025   55 STYTLTaDGNLVIYNGRFQKEknIPLSRITDVELKRLFGLKHLRFTRYVLVHYDNDKVIDLLPEKPEEFMNALVRR 130
Cdd:pfam06713   1 TKYILT-EGTLIIKSGFFKKK--IPIEDITKIRKTKSPLSSPALSLDRLEIKYGKYDTILISPKDKEEFIKLLKKR 73
 
Name Accession Description Interval E-value
bPH_4 pfam06713
Bacterial PH domain; This family consists of several hypothetical proteins specific to ...
 55-130 1.48e-09

Bacterial PH domain; This family consists of several hypothetical proteins specific to Oceanobacillus and Bacillus species. Members of this family are typically around 130 residues in length. The function of this family is unknown. Members of this family have a PH domain like structure.


Pssm-ID: 369049  Cd Length: 74  Bit Score: 51.07  E-value: 1.48e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 517263025   55 STYTLTaDGNLVIYNGRFQKEknIPLSRITDVELKRLFGLKHLRFTRYVLVHYDNDKVIDLLPEKPEEFMNALVRR 130
Cdd:pfam06713   1 TKYILT-EGTLIIKSGFFKKK--IPIEDITKIRKTKSPLSSPALSLDRLEIKYGKYDTILISPKDKEEFIKLLKKR 73
YdbT COG3428
Uncharacterized membrane protein YdbT, contains bPH2 (bacterial pleckstrin homology) domain ...
 16-140 4.63e-06

Uncharacterized membrane protein YdbT, contains bPH2 (bacterial pleckstrin homology) domain [Function unknown];


Pssm-ID: 442654 [Multi-domain]  Cd Length: 410  Bit Score: 44.70  E-value: 4.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517263025  16 LFLILFTLIMLVAFWYKGAALIGMFFAMIVIINIERIIHsTYTLTADGnLVIYNGRFQK-EKNIPLSRITDVELK----- 89
Cdd:COG3428   28 LLLLLAGVGAGGGLLWVLLIALVLLLLLLLVSYLRWRTT-RYRITDDR-LIVRSGVLSRkRREIPLDRIQSVDVSqpllh 105

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 517263025  90 RLFGLKHLRFtrYVLVHYDNDKVIDLLP-EKPEEFMNALVRRLEHKEEDEDT 140
Cdd:COG3428  106 RLFGLGTVRI--ETAGGGESEVELDALSvPEAERLRRLLLERAAGAAEEEAE 155
 
Name Accession Description Interval E-value
bPH_4 pfam06713
Bacterial PH domain; This family consists of several hypothetical proteins specific to ...
 55-130 1.48e-09

Bacterial PH domain; This family consists of several hypothetical proteins specific to Oceanobacillus and Bacillus species. Members of this family are typically around 130 residues in length. The function of this family is unknown. Members of this family have a PH domain like structure.


Pssm-ID: 369049  Cd Length: 74  Bit Score: 51.07  E-value: 1.48e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 517263025   55 STYTLTaDGNLVIYNGRFQKEknIPLSRITDVELKRLFGLKHLRFTRYVLVHYDNDKVIDLLPEKPEEFMNALVRR 130
Cdd:pfam06713   1 TKYILT-EGTLIIKSGFFKKK--IPIEDITKIRKTKSPLSSPALSLDRLEIKYGKYDTILISPKDKEEFIKLLKKR 73
YdbT COG3428
Uncharacterized membrane protein YdbT, contains bPH2 (bacterial pleckstrin homology) domain ...
 16-140 4.63e-06

Uncharacterized membrane protein YdbT, contains bPH2 (bacterial pleckstrin homology) domain [Function unknown];


Pssm-ID: 442654 [Multi-domain]  Cd Length: 410  Bit Score: 44.70  E-value: 4.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517263025  16 LFLILFTLIMLVAFWYKGAALIGMFFAMIVIINIERIIHsTYTLTADGnLVIYNGRFQK-EKNIPLSRITDVELK----- 89
Cdd:COG3428   28 LLLLLAGVGAGGGLLWVLLIALVLLLLLLLVSYLRWRTT-RYRITDDR-LIVRSGVLSRkRREIPLDRIQSVDVSqpllh 105

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 517263025  90 RLFGLKHLRFtrYVLVHYDNDKVIDLLP-EKPEEFMNALVRRLEHKEEDEDT 140
Cdd:COG3428  106 RLFGLGTVRI--ETAGGGESEVELDALSvPEAERLRRLLLERAAGAAEEEAE 155
bPH_2 pfam03703
Bacterial PH domain; Domain found in uncharacterized family of membrane proteins. 1-3 copies ...
 54-127 8.11e-03

Bacterial PH domain; Domain found in uncharacterized family of membrane proteins. 1-3 copies found in each protein, with each copy flanked by transmembrane helices. Members of this family have a PH domain like structure.


Pssm-ID: 427450 [Multi-domain]  Cd Length: 78  Bit Score: 33.34  E-value: 8.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517263025   54 HSTYTLTaDGNLVIYNGRFQKEK-NIPLSRITDVELK-----RLFGLKHLRFTryvLVHYDNDKVIDLLPEKPEEFMNAL 127
Cdd:pfam03703   3 ATGYTIT-DRRVVVRSGILGRKRvDIPLERIQDVSLSqsplqRRLGLGTIVID---TAGGSGVRLPLRDVPDAEELREWL 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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