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Conserved domains on  [gi|517068822|ref|WP_018257640|]
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(d)CMP kinase [Halomicrobium katesii]

Protein Classification

(d)CMP kinase( domain architecture ID 11480180)

(d)CMP kinase catalyzes the phosphorylation of cytidine monophosphate (CMP) or dCMP to produce cytidine diphosphate (CDP) or dCDP, using ATP as the preferred phosphoryl donor

CATH:  3.40.50.300
EC:  2.7.4.25
Gene Ontology:  GO:0036431|GO:0006220|GO:0005524
PubMed:  10218107
SCOP:  4004025

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK04182 PRK04182
cytidylate kinase; Provisional
 1-180 1.14e-101

cytidylate kinase; Provisional


:

Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 290.55  E-value: 1.14e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822   1 MLITVSGPAGSGKSTLAANLAEELGYDHVSGGDIFRSLAEERGVSLVELNQQAESDDQIDRDLDRRLRSTAREEDDLVLE 80
Cdd:PRK04182   1 MIITISGPPGSGKTTVARLLAEKLGLKHVSAGEIFRELAKERGMSLEEFNKYAEEDPEIDKEIDRRQLEIAEKEDNVVLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822  81 SRLAGWMAGDHADLKLWLDAPLDVRAERIADREEKSVTEARDETQARAESEGLRYQEYYGIDIDDRSIYDLSINTARWDE 160
Cdd:PRK04182  81 GRLAGWMAKDYADLKIWLKAPLEVRAERIAEREGISVEEALEETIEREESEAKRYKEYYGIDIDDLSIYDLVINTSRWDP 160

                        170       180
                 ....*....|....*....|
gi 517068822 161 GGVQELIVAAVDAYDPDGDE 180
Cdd:PRK04182 161 EGVFDIILTAIDKLLKAKDE 180
 
Name Accession Description Interval E-value
PRK04182 PRK04182
cytidylate kinase; Provisional
 1-180 1.14e-101

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 290.55  E-value: 1.14e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822   1 MLITVSGPAGSGKSTLAANLAEELGYDHVSGGDIFRSLAEERGVSLVELNQQAESDDQIDRDLDRRLRSTAREEDDLVLE 80
Cdd:PRK04182   1 MIITISGPPGSGKTTVARLLAEKLGLKHVSAGEIFRELAKERGMSLEEFNKYAEEDPEIDKEIDRRQLEIAEKEDNVVLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822  81 SRLAGWMAGDHADLKLWLDAPLDVRAERIADREEKSVTEARDETQARAESEGLRYQEYYGIDIDDRSIYDLSINTARWDE 160
Cdd:PRK04182  81 GRLAGWMAKDYADLKIWLKAPLEVRAERIAEREGISVEEALEETIEREESEAKRYKEYYGIDIDDLSIYDLVINTSRWDP 160

                        170       180
                 ....*....|....*....|
gi 517068822 161 GGVQELIVAAVDAYDPDGDE 180
Cdd:PRK04182 161 EGVFDIILTAIDKLLKAKDE 180
cyt_kin_arch TIGR02173
cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. ...
 1-172 3.31e-77

cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. Members of this family are found in the archaea and in spirochaetes, and differ considerably from the common bacterial form of cytidylate kinase described by TIGR00017.


Pssm-ID: 274012 [Multi-domain]  Cd Length: 171  Bit Score: 228.46  E-value: 3.31e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822    1 MLITVSGPAGSGKSTLAANLAEELGYDHVSGGDIFRSLAEERGVSLVELNQQAESDDQIDRDLDRRLRSTAREEDDLVLE 80
Cdd:TIGR02173   1 MIITISGPPGSGKTTVAKILAEKLSLKLISAGDIFRELAAKMGLDLIEFLNYAEENPEIDKKIDRRIHEIALKEKNVVLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822   81 SRLAGWMAGDHADLKLWLDAPLDVRAERIADREEKSVTEARDETQARAESEGLRYQEYYGIDIDDRSIYDLSINTARWDE 160
Cdd:TIGR02173  81 SRLAGWIVREYADVKIWLKAPLEVRARRIAKREGKSLTVARSETIEREESEKRRYLKFYGIDIDDLSIYDLVINTSNWDP 160

                         170
                  ....*....|..
gi 517068822  161 GGVqELIVAAVD 172
Cdd:TIGR02173 161 NNV-DIILDALD 171
CmkB COG1102
Cytidylate kinase [Nucleotide transport and metabolism];
1-178 1.94e-64

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440719 [Multi-domain]  Cd Length: 188  Bit Score: 196.59  E-value: 1.94e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822   1 MLITVSGPAGSGKSTLAANLAEELGYDHVsGGDIFRSLAEERGVSLVELNQQAE-----------SDDQIDRDLDRRLRS 69
Cdd:COG1102    1 MVITISREPGSGGTTIAKRLAEKLGLPLY-DGEILREAAKERGLSEEEFEKLDEkapsllyrdtaEEDEIDRALDKVIRE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822  70 TAREeDDLVLESRLAGWMAGDH-ADLKLWLDAPLDVRAERIADREEKSVTEARDETQARAESEGLRYQEYYGIDIDDRSI 148
Cdd:COG1102   80 LARK-GNCVIVGRLADWILRDRpNVLKVFLTAPLEVRVKRIAEREGISEEEAEKEIKKRDKSRAKYYKYYYGIDWGDPSN 158

                        170       180       190
                 ....*....|....*....|....*....|
gi 517068822 149 YDLSINTARWDEGGVQELIVAAVDAYDPDG 178
Cdd:COG1102  159 YDLVINTSRLGIEEAVDLILAAIEAREKKE 188
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 3-155 3.28e-37

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 126.06  E-value: 3.28e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822   3 ITVSGPAGSGKSTLAANLAEELGYDHVSGGDIfRSLAEERGVSLVELNQQaesddqIDRDLDRRLRStAREEDDLVLESR 82
Cdd:cd02020    2 IAIDGPAGSGKSTVAKLLAKKLGLPYLDTGGI-RTEEVGKLASEVAAIPE------VRKALDERQRE-LAKKPGIVLEGR 73

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 517068822  83 LAGWMAGDHADLKLWLDAPLDVRAERIAD-----REEKSVTEARDETQARAESEGLRYQEYYgididDRSIYDLSINT 155
Cdd:cd02020   74 DIGTVVFPDADLKIFLTASPEVRAKRRAKqlqakGEGVDLEEILAEIIERDERDSTRYVAPL-----KLAEDAIVIDT 146
Cytidylate_kin2 pfam13189
Cytidylate kinase-like family; This family includes enzymes related to cytidylate kinase.
 3-157 6.24e-24

Cytidylate kinase-like family; This family includes enzymes related to cytidylate kinase.


Pssm-ID: 433023 [Multi-domain]  Cd Length: 176  Bit Score: 92.69  E-value: 6.24e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822    3 ITVSGPAGSGKSTLAANLAEELGYDHVSGgDIFRSLAEERGVSLVEL---------------------NQQAESDDQIDR 61
Cdd:pfam13189   2 ITISRQYGSGGTTIAKKLAEKLGYPFYDR-EILDEIAKELGISEEEFelfdeksrlssflyslaggrvRGDALSDDRLFD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822   62 DLDRRLRSTAREeDDLVLESRLAGWMAGDHAD-LKLWLDAPLDVRAERIADREEKSVTEARDETQARAESEGLRYQEYYG 140
Cdd:pfam13189  81 AQSKVIRELAAE-DNCVIVGRGADYILKDIPNvLRVFLTAPLEDRVKRVMEREGLSEEEARELIKETDKRRAKYYKYYTG 159

                         170
                  ....*....|....*..
gi 517068822  141 IDIDDRSIYDLSINTAR 157
Cdd:pfam13189 160 KDWGDAENYDLVINTSK 176
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 3-68 1.28e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 40.43  E-value: 1.28e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 517068822     3 ITVSGPAGSGKSTLAANLAEELGYDH-----VSGGDIFRSLAEERGVSLVELNQQAESDDQIDRDLDRRLR 68
Cdd:smart00382   5 ILIVGPPGSGKTTLARALARELGPPGggviyIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALALAR 75
 
Name Accession Description Interval E-value
PRK04182 PRK04182
cytidylate kinase; Provisional
 1-180 1.14e-101

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 290.55  E-value: 1.14e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822   1 MLITVSGPAGSGKSTLAANLAEELGYDHVSGGDIFRSLAEERGVSLVELNQQAESDDQIDRDLDRRLRSTAREEDDLVLE 80
Cdd:PRK04182   1 MIITISGPPGSGKTTVARLLAEKLGLKHVSAGEIFRELAKERGMSLEEFNKYAEEDPEIDKEIDRRQLEIAEKEDNVVLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822  81 SRLAGWMAGDHADLKLWLDAPLDVRAERIADREEKSVTEARDETQARAESEGLRYQEYYGIDIDDRSIYDLSINTARWDE 160
Cdd:PRK04182  81 GRLAGWMAKDYADLKIWLKAPLEVRAERIAEREGISVEEALEETIEREESEAKRYKEYYGIDIDDLSIYDLVINTSRWDP 160

                        170       180
                 ....*....|....*....|
gi 517068822 161 GGVQELIVAAVDAYDPDGDE 180
Cdd:PRK04182 161 EGVFDIILTAIDKLLKAKDE 180
cyt_kin_arch TIGR02173
cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. ...
 1-172 3.31e-77

cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. Members of this family are found in the archaea and in spirochaetes, and differ considerably from the common bacterial form of cytidylate kinase described by TIGR00017.


Pssm-ID: 274012 [Multi-domain]  Cd Length: 171  Bit Score: 228.46  E-value: 3.31e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822    1 MLITVSGPAGSGKSTLAANLAEELGYDHVSGGDIFRSLAEERGVSLVELNQQAESDDQIDRDLDRRLRSTAREEDDLVLE 80
Cdd:TIGR02173   1 MIITISGPPGSGKTTVAKILAEKLSLKLISAGDIFRELAAKMGLDLIEFLNYAEENPEIDKKIDRRIHEIALKEKNVVLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822   81 SRLAGWMAGDHADLKLWLDAPLDVRAERIADREEKSVTEARDETQARAESEGLRYQEYYGIDIDDRSIYDLSINTARWDE 160
Cdd:TIGR02173  81 SRLAGWIVREYADVKIWLKAPLEVRARRIAKREGKSLTVARSETIEREESEKRRYLKFYGIDIDDLSIYDLVINTSNWDP 160

                         170
                  ....*....|..
gi 517068822  161 GGVqELIVAAVD 172
Cdd:TIGR02173 161 NNV-DIILDALD 171
CmkB COG1102
Cytidylate kinase [Nucleotide transport and metabolism];
1-178 1.94e-64

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440719 [Multi-domain]  Cd Length: 188  Bit Score: 196.59  E-value: 1.94e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822   1 MLITVSGPAGSGKSTLAANLAEELGYDHVsGGDIFRSLAEERGVSLVELNQQAE-----------SDDQIDRDLDRRLRS 69
Cdd:COG1102    1 MVITISREPGSGGTTIAKRLAEKLGLPLY-DGEILREAAKERGLSEEEFEKLDEkapsllyrdtaEEDEIDRALDKVIRE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822  70 TAREeDDLVLESRLAGWMAGDH-ADLKLWLDAPLDVRAERIADREEKSVTEARDETQARAESEGLRYQEYYGIDIDDRSI 148
Cdd:COG1102   80 LARK-GNCVIVGRLADWILRDRpNVLKVFLTAPLEVRVKRIAEREGISEEEAEKEIKKRDKSRAKYYKYYYGIDWGDPSN 158

                        170       180       190
                 ....*....|....*....|....*....|
gi 517068822 149 YDLSINTARWDEGGVQELIVAAVDAYDPDG 178
Cdd:COG1102  159 YDLVINTSRLGIEEAVDLILAAIEAREKKE 188
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 3-155 3.28e-37

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 126.06  E-value: 3.28e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822   3 ITVSGPAGSGKSTLAANLAEELGYDHVSGGDIfRSLAEERGVSLVELNQQaesddqIDRDLDRRLRStAREEDDLVLESR 82
Cdd:cd02020    2 IAIDGPAGSGKSTVAKLLAKKLGLPYLDTGGI-RTEEVGKLASEVAAIPE------VRKALDERQRE-LAKKPGIVLEGR 73

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 517068822  83 LAGWMAGDHADLKLWLDAPLDVRAERIAD-----REEKSVTEARDETQARAESEGLRYQEYYgididDRSIYDLSINT 155
Cdd:cd02020   74 DIGTVVFPDADLKIFLTASPEVRAKRRAKqlqakGEGVDLEEILAEIIERDERDSTRYVAPL-----KLAEDAIVIDT 146
Cytidylate_kin2 pfam13189
Cytidylate kinase-like family; This family includes enzymes related to cytidylate kinase.
 3-157 6.24e-24

Cytidylate kinase-like family; This family includes enzymes related to cytidylate kinase.


Pssm-ID: 433023 [Multi-domain]  Cd Length: 176  Bit Score: 92.69  E-value: 6.24e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822    3 ITVSGPAGSGKSTLAANLAEELGYDHVSGgDIFRSLAEERGVSLVEL---------------------NQQAESDDQIDR 61
Cdd:pfam13189   2 ITISRQYGSGGTTIAKKLAEKLGYPFYDR-EILDEIAKELGISEEEFelfdeksrlssflyslaggrvRGDALSDDRLFD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822   62 DLDRRLRSTAREeDDLVLESRLAGWMAGDHAD-LKLWLDAPLDVRAERIADREEKSVTEARDETQARAESEGLRYQEYYG 140
Cdd:pfam13189  81 AQSKVIRELAAE-DNCVIVGRGADYILKDIPNvLRVFLTAPLEDRVKRVMEREGLSEEEARELIKETDKRRAKYYKYYTG 159

                         170
                  ....*....|....*..
gi 517068822  141 IDIDDRSIYDLSINTAR 157
Cdd:pfam13189 160 KDWGDAENYDLVINTSK 176
AAA_17 pfam13207
AAA domain;
6-122 3.17e-15

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 68.81  E-value: 3.17e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822    6 SGPAGSGKSTLAANLAEELGYDHVSGGDIFRSLAEERGvsLVELNQQ-AESDDQIDRDLDRRLRSTAREED---DLVLES 81
Cdd:pfam13207   1 TGVPGSGKTTQLKKLAEKLGFPHISAGDLLREEAKERG--LVEDRDEmRKLPLEPQKELQKLAAERIAEEAgegGVIVDG 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 517068822   82 RLAG-WMAGDHADLKLWLDAP--------LDVRAERIADREEKSVTEARD 122
Cdd:pfam13207  79 HPRIkTPAGYLPGLPVEVLRElkpdaiilLEADPEEILERRLKDRTRGRD 128
AAA_18 pfam13238
AAA domain;
3-123 1.21e-12

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 62.06  E-value: 1.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822    3 ITVSGPAGSGKSTLAANLAEELGYdhvsgGDIFRSLAEERGVSLVELNQQAESdDQIDRDLDRRLRSTARE------EDD 76
Cdd:pfam13238   1 ILITGTPGVGKTTLAKELSKRLGF-----GDNVRDLALENGLVLGDDPETRES-KRLDEDKLDRLLDLLEEnaaleeGGN 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 517068822   77 LVLESRLAGWMAGDHADLKL-WLDAPLDVRAERIADREEKSVTEARDE 123
Cdd:pfam13238  75 LIIDGHLAELEPERAKDLVGiVLRASPEELLERLEKRGYEEAKIKENE 122
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 1-129 3.87e-10

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 55.39  E-value: 3.87e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822    1 MLITVsGPAGSGKSTLAANLAEELGYDHVSGGDIFRSLAEERGVSLveLNQQAESDDQIDRdLDRRLRSTAREEDDLVL- 79
Cdd:pfam13671   1 LILLV-GLPGSGKSTLARRLLEELGAVRLSSDDERKRLFGEGRPSI--SYYTDATDRTYER-LHELARIALRAGRPVILd 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 517068822   80 -----ESRLAGWMAG----DHADLKLWLDAPLDVRAERIADREEKS------VTEARDETQARAE 129
Cdd:pfam13671  77 atnlrRDERARLLALareyGVPVRIVVFEAPEEVLRERLAARARAGgdpsdvPEEVLDRQKARFE 141
Cytidylate_kin pfam02224
Cytidylate kinase; Cytidylate kinase EC:2.7.4.14 catalyzes the phosphorylation of cytidine 5 ...
 3-127 6.91e-09

Cytidylate kinase; Cytidylate kinase EC:2.7.4.14 catalyzes the phosphorylation of cytidine 5'-monophosphate (dCMP) to cytidine 5'-diphosphate (dCDP) in the presence of ATP or GTP.


Pssm-ID: 280401 [Multi-domain]  Cd Length: 211  Bit Score: 53.46  E-value: 6.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822    3 ITVSGPAGSGKSTLAANLAEELGYDHVSGGDIFRSLA---EERGVSLVELNQQAESDDQID------------RDLDRRL 67
Cdd:pfam02224   1 IAIDGPSGSGKSTVARILARKLGYKYLDTGAMYRALAlaaLRQKVDLTDEDALAELASEVDisfghtevflngEDVSSEI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822   68 RS-------------------------TAREEDDLVLESRLAGWMAGDHADLKLWLDAPLDVRAE-RIADREEKSVTEAR 121
Cdd:pfam02224  81 RTdevaqaasqvaaipavrarlnklqrQLAKNGNIVMEGRDIGTVVFPDAEVKIFLTASPEERAKrRYKQLQAKGLSVDF 160


                  ....*.
gi 517068822  122 DETQAR 127
Cdd:pfam02224 161 EELLAE 166
Cmk COG0283
Cytidylate kinase [Nucleotide transport and metabolism];
1-108 9.48e-09

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440052 [Multi-domain]  Cd Length: 220  Bit Score: 53.10  E-value: 9.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822   1 MLITVSGPAGSGKSTLAANLAEELGYDHVSGGDIFRSLA---EERGVSL------------VELNQQAESDDQI----DR 61
Cdd:COG0283    1 PVIAIDGPAGSGKSTVAKALAKRLGYHYLDTGAMYRAVAlaaLRNGIDLddeealaalarnLDIEFETDPGGQRvflnGE 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 517068822  62 DLDRRLRSTA-------------------------REEDDLVLESRlagwmagD-------HADLKLWLDAPLDVRAER 108
Cdd:COG0283   81 DVTDEIRTEEvsnavskvaaipevrealvalqrafAKAPGLVADGR-------DigtvvfpDAELKIFLTASAEERARR 152
cmk TIGR00017
cytidylate kinase; This family consists of cytidylate kinase, which catalyzes the ...
 1-108 3.63e-08

cytidylate kinase; This family consists of cytidylate kinase, which catalyzes the phosphorylation of cytidine 5-monophosphate (dCMP) to cytidine 5 -diphosphate (dCDP) in the presence of ATP or GTP. UMP and dCMP can also act as acceptors. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 129128 [Multi-domain]  Cd Length: 217  Bit Score: 51.27  E-value: 3.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822    1 MLITVSGPAGSGKSTLAANLAEELGYDHVSGGDIFRSLA---EERGVSLVELNQQAESDDQIDRDL-------------- 63
Cdd:TIGR00017   3 MIIAIDGPSGAGKSTVAKAVAEKLGYAYLDSGAMYRAIAlaaLQNRVDLTSEDALAELISHLDIRFiptngevevflnge 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 517068822   64 --------------------DRRLRSTA-------REEDDLVLESRLAGWMAGDHADLKLWLDAPLDVRAER 108
Cdd:TIGR00017  83 dvseairtqevanaaskvavFPKVREALlkrqqalAKNDGIIADGRDIGTVVFPNAEVKIFLDASVEERAKR 154
TMPK cd01672
Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the ...
 1-137 6.27e-07

Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step in either de novo or salvage biosynthesis of thymidine triphosphate (TTP).


Pssm-ID: 238835  Cd Length: 200  Bit Score: 47.65  E-value: 6.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822   1 MLITVSGPAGSGKSTLAANLAEEL---GYDHV-----SGGDIFRSLAEergvslVELNQQAESDDQI--------DR-DL 63
Cdd:cd01672    1 MFIVFEGIDGAGKTTLIELLAERLearGYEVVltrepGGTPIGEAIRE------LLLDPEDEKMDPRaelllfaaDRaQH 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822  64 DRRLRSTAREEDDLVL-----ESRLAGWMAGDHA------------------DLKLWLDAPLDVRAERIADREEksvtea 120
Cdd:cd01672   75 VEEVIKPALARGKIVLsdrfvDSSLAYQGAGRGLgealiealndlatgglkpDLTILLDIDPEVGLARIEARGR------ 148

                        170
                 ....*....|....*..
gi 517068822 121 rdetQARAESEGLRYQE 137
Cdd:cd01672  149 ----DDRDEQEGLEFHE 161
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
2-160 1.17e-06

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 46.44  E-value: 1.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822   2 LITVSGPAGSGKSTLAANLAEELGYDHVSGGDIFRSLAeerGVSLVELNQQAESDDQIDRDLDRRLRSTAREEDDLVLES 81
Cdd:COG0645    1 LILVCGLPGSGKSTLARALAERLGAVRLRSDVVRKRLF---GAGLAPLERSPEATARTYARLLALARELLAAGRSVILDA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822  82 ---------RLAGWMAGDHADLKL-WLDAPLDVRAERIADREEKSVTEARDETQARAeseglryQEYYGIDIDDRSIYDL 151
Cdd:COG0645   78 tflrraqreAFRALAEEAGAPFVLiWLDAPEEVLRERLEARNAEGGDSDATWEVLER-------QLAFEEPLTEDEGFLL 150


                 ....*....
gi 517068822 152 SINTARWDE 160
Cdd:COG0645  151 VVDTSGLEE 159
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 7-36 1.24e-06

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 47.04  E-value: 1.24e-06
                         10        20        30
                 ....*....|....*....|....*....|
gi 517068822   7 GPAGSGKSTLAANLAEELGYDHVSGGDIFR 36
Cdd:COG0563    7 GPPGAGKGTQAKRLAEKYGIPHISTGDMLR 36
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 3-36 1.30e-06

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 46.85  E-value: 1.30e-06
                         10        20        30
                 ....*....|....*....|....*....|....
gi 517068822   3 ITVSGPAGSGKSTLAANLAEELGYDHVSGGDIFR 36
Cdd:cd01428    2 ILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLR 35
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 1-112 1.98e-06

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 46.37  E-value: 1.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822   1 MLITVSGPAGSGKSTLAANLAEELGYDHV---SGGDIFRSLA----EERGV----SLVELNQqaesdDQIDRDLD--RRL 67
Cdd:COG0572    8 RIIGIAGPSGSGKTTFARRLAEQLGADKVvviSLDDYYKDREhlplDERGKpnfdHPEAFDL-----DLLNEHLEplKAG 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 517068822  68 RSTAREEDDLVLESRLAGWM--------------------AGDHADLKLWLDAPLDVRAERIADR 112
Cdd:COG0572   83 ESVELPVYDFATGTRSGETVkvepadviivegihalndelLRDLLDLKIYVDADTDVRLIRRIVR 147
dNK cd01673
Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to ...
 3-29 3.48e-06

Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1.113), adenosine (EC 2.7.1.76), and thymidine (EC 2.7.1.21) kinases. They are key enzymes in the salvage of deoxyribonucleosides originating from extra- or intracellular breakdown of DNA.


Pssm-ID: 238836  Cd Length: 193  Bit Score: 45.30  E-value: 3.48e-06
                         10        20
                 ....*....|....*....|....*..
gi 517068822   3 ITVSGPAGSGKSTLAANLAEELGYDHV 29
Cdd:cd01673    2 IVVEGNIGAGKSTLAKELAEHLGYEVV 28
GntK cd02021
Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting ...
 2-113 4.84e-06

Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits.


Pssm-ID: 238979 [Multi-domain]  Cd Length: 150  Bit Score: 44.55  E-value: 4.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822   2 LITVSGPAGSGKSTLAANLAEELGYDHVSgGDIFRSLA----EERGVSLvelnqqaeSDDqiDRDL------DRRLRSTA 71
Cdd:cd02021    1 IIVVMGVSGSGKSTVGKALAERLGAPFID-GDDLHPPAniakMAAGIPL--------NDE--DRWPwlqaltDALLAKLA 69

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 517068822  72 REEDDLV-----LESRLAGWMAGDHADLKL---WLDAPLDVRAERIADRE 113
Cdd:cd02021   70 SAGEGVVvacsaLKRIYRDILRGGAANPRVrfvHLDGPREVLAERLAARK 119
PRK11860 PRK11860
bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;
3-108 5.28e-06

bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;


Pssm-ID: 237003 [Multi-domain]  Cd Length: 661  Bit Score: 45.81  E-value: 5.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822   3 ITVSGPAGSGKSTLAANLAEELGYDHVSGGDIFR--SLAEER-GVSLVELNQQAE---------SDDQI---DRDLDRRL 67
Cdd:PRK11860 445 ICIDGPTASGKGTVAARVAEALGYHYLDSGALYRltALAALRaGVALDDEAAIAAlarglpvrfEGDRIwlgGEDVTDAI 524

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 517068822  68 RSTA-------------------------REEDDLVLESRLAGWMAGDHADLKLWLDAPLDVRAER 108
Cdd:PRK11860 525 RTEAagmgasrvsalpavraallalqrsfRRLPGLVADGRDMGTVIFPDAALKVFLTASAEARAER 590
Fap7 COG1936
Broad-specificity NMP kinase [Nucleotide transport and metabolism];
1-84 7.04e-06

Broad-specificity NMP kinase [Nucleotide transport and metabolism];


Pssm-ID: 441539 [Multi-domain]  Cd Length: 173  Bit Score: 44.42  E-value: 7.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822   1 MLITVSGPAGSGKSTLAANLAEELGYDHVSGGDifrsLAEERGVsLVELNQQAESDDqIDRD-LDRRLRStaREEDDLVL 79
Cdd:COG1936    1 MRIAITGTPGTGKTTVAKLLAERLGLEVIHLND----LVKEEGL-YTEVDEERDSLV-VDEDaLAEELEE--LKEGDVII 72


                 ....*
gi 517068822  80 ESRLA 84
Cdd:COG1936   73 EGHLA 77
adk PRK02496
adenylate kinase; Provisional
 7-120 9.23e-06

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 44.36  E-value: 9.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822   7 GPAGSGKSTLAANLAEELGYDHVSGGDIFRSLAEERgvslVELNQQAES--------DDQIDRDLDR------------- 65
Cdd:PRK02496   8 GPPGAGKGTQAVVLAEHLHIPHISTGDILRQAIKEQ----TPLGIKAQGymdkgelvPDQLVLDLVQerlqqpdaangwi 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822  66 -----RLRSTAREEDDLVLEsrlagwmAGDHADLKLWLDAPLDVRAERIADREEKSVTEA 120
Cdd:PRK02496  84 ldgfpRKVTQAAFLDELLQE-------IGQSGERVVNLDVPDDVVVERLLARGRKDDTEE 136
SK cd00464
Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic ...
 7-148 9.52e-06

Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids, p-aminobenzoic acid, folate and ubiquinone. Shikimate kinase catalyses the phosphorylation of the 3-hydroxyl group of shikimic acid using ATP.


Pssm-ID: 238260 [Multi-domain]  Cd Length: 154  Bit Score: 43.70  E-value: 9.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822   7 GPAGSGKSTLAANLAEELGYDHVsggDIFRSLAEERGVSLVELnqQAESDDQIDRDLDRRLRSTAREEDDLVL------- 79
Cdd:cd00464    6 GMMGAGKTTVGRLLAKALGLPFV---DLDELIEQRAGMSIPEI--FAEEGEEGFRELEREVLLLLLTKENAVIatgggav 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 517068822  80 ESRLAGWMAGDHADLkLWLDAPLDVRAERIADREE--KSVTEARDETQARAESEGLRYQEY--YGIDIDDRSI 148
Cdd:cd00464   81 LREENRRLLLENGIV-VWLDASPEELLERLARDKTrpLLQDEDPERLRELLEEREPLYREVadLTIDTDELSP 152
ADK pfam00406
Adenylate kinase;
5-37 2.00e-05

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 43.07  E-value: 2.00e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 517068822    5 VSGPAGSGKSTLAANLAEELGYDHVSGGDIFRS 37
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRA 33
PRK06217 PRK06217
hypothetical protein; Validated
 1-114 2.05e-05

hypothetical protein; Validated


Pssm-ID: 168472  Cd Length: 183  Bit Score: 43.12  E-value: 2.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822   1 MLITVSGPAGSGKSTLAANLAEELGYDHVSGGDIF----------RSLAEERGvslvelnqqaesddqidrdldRRLRST 70
Cdd:PRK06217   2 MRIHITGASGSGTTTLGAALAERLDIPHLDTDDYFwlptdppfttKRPPEERL---------------------RLLLED 60

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 517068822  71 AREEDDLVLESRLAGWmaGD----HADLKLWLDAPLDVRAERIADREE 114
Cdd:PRK06217  61 LRPREGWVLSGSALGW--GDplepLFDLVVFLTIPPELRLERLRLREF 106
PRK14526 PRK14526
adenylate kinase; Provisional
 1-37 4.07e-05

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 42.53  E-value: 4.07e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 517068822   1 MLITVSGPAGSGKSTLAANLAEELGYDHVSGGDIFRS 37
Cdd:PRK14526   1 MKLVFLGPPGSGKGTIAKILSNELNYYHISTGDLFRE 37
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 5-36 6.05e-05

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 41.97  E-value: 6.05e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 517068822    5 VSGPAGSGKSTLAANLAEELGYDHVSGGDIFR 36
Cdd:TIGR01359   4 VLGGPGSGKGTQCAKIVENFGFTHLSAGDLLR 35
adk PRK00279
adenylate kinase; Reviewed
 1-36 7.62e-05

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 41.67  E-value: 7.62e-05
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 517068822   1 MLITVSGPAGSGKSTLAANLAEELGYDHVSGGDIFR 36
Cdd:PRK00279   1 MRLILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLR 36
Dck COG1428
Deoxyadenosine/deoxycytidine kinase [Nucleotide transport and metabolism];
1-27 9.60e-05

Deoxyadenosine/deoxycytidine kinase [Nucleotide transport and metabolism];


Pssm-ID: 441037 [Multi-domain]  Cd Length: 205  Bit Score: 41.31  E-value: 9.60e-05
                         10        20
                 ....*....|....*....|....*..
gi 517068822   1 MLITVSGPAGSGKSTLAANLAEELGYD 27
Cdd:COG1428    4 RYIAVEGNIGAGKTTLARLLAEHLGAE 30
GntK COG3265
Gluconate kinase [Carbohydrate transport and metabolism]; Gluconate kinase is part of the ...
 1-113 1.03e-04

Gluconate kinase [Carbohydrate transport and metabolism]; Gluconate kinase is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442496 [Multi-domain]  Cd Length: 164  Bit Score: 40.88  E-value: 1.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822   1 MLITVSGPAGSGKSTLAANLAEELG---YDhvsgGDIFRSLAE----ERGVSLvelnqqaeSDDqiDRD--LDR---RLR 68
Cdd:COG3265    2 MVIVVMGVSGSGKSTVGQALAERLGwpfID----GDDFHPPANiakmAAGIPL--------TDE--DRApwLEAladAIA 67

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 517068822  69 STAREEDDLVL------ES---RLagwmAGDHADLK-LWLDAPLDVRAERIADRE 113
Cdd:COG3265   68 AHLAAGEGAVLacsalkRSyrdRL----REGNPDVRfVYLDGSRELIAERLAARK 118
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 3-68 1.28e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 40.43  E-value: 1.28e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 517068822     3 ITVSGPAGSGKSTLAANLAEELGYDH-----VSGGDIFRSLAEERGVSLVELNQQAESDDQIDRDLDRRLR 68
Cdd:smart00382   5 ILIVGPPGSGKTTLARALARELGPPGggviyIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALALAR 75
PRK03839 PRK03839
putative kinase; Provisional
 1-112 1.41e-04

putative kinase; Provisional


Pssm-ID: 179660  Cd Length: 180  Bit Score: 40.86  E-value: 1.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822   1 MLITVSGPAGSGKSTLAANLAEELGYDHVSggdiFRSLAEERGVSlvelnqqAESDDQIDRDLDRRLRSTARE--EDDLV 78
Cdd:PRK03839   1 MIIAITGTPGVGKTTVSKLLAEKLGYEYVD----LTEFALKKGIG-------EEKDDEMEIDFDKLAYFIEEEfkEKNVV 69

                         90       100       110
                 ....*....|....*....|....*....|....
gi 517068822  79 LESRLAGWMagdHADLKLWLDAPLDVRAERIADR 112
Cdd:PRK03839  70 LDGHLSHLL---PVDYVIVLRAHPKIIKERLKER 100
NK cd02019
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of ...
 2-29 1.59e-04

Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars. Members of this family play a wide variety of essential roles in nucleotide metabolism, the biosynthesis of coenzymes and aromatic compounds, as well as the metabolism of sugar and sulfate.


Pssm-ID: 238977 [Multi-domain]  Cd Length: 69  Bit Score: 38.47  E-value: 1.59e-04
                         10        20
                 ....*....|....*....|....*...
gi 517068822   2 LITVSGPAGSGKSTLAANLAEELGYDHV 29
Cdd:cd02019    1 IIAITGGSGSGKSTVAKKLAEQLGGRSV 28
NDUO42 cd02030
NADH:Ubiquinone oxioreductase, 42 kDa (NDUO42) is a family of proteins that are highly similar ...
 2-35 1.65e-04

NADH:Ubiquinone oxioreductase, 42 kDa (NDUO42) is a family of proteins that are highly similar to deoxyribonucleoside kinases (dNK). Members of this family have been identified as one of the subunits of NADH:Ubiquinone oxioreductase (complex I), a multi-protein complex located in the inner mitochondrial membrane. The main function of the complex is to transport electrons from NADH to ubiquinone, which is accompanied by the translocation of protons from the mitochondrial matrix to the inter membrane space.


Pssm-ID: 238988  Cd Length: 219  Bit Score: 40.80  E-value: 1.65e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 517068822   2 LITVSGPAGSGKSTLAANLAEELGYDHVSGGDIF 35
Cdd:cd02030    1 VITVDGNIASGKGKLAKELAEKLGMKYFPEAGIH 34
AAA_22 pfam13401
AAA domain;
2-69 2.10e-04

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 39.63  E-value: 2.10e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 517068822    2 LITVSGPAGSGKSTLAANLAEELGYDHV-----------SGGDIFRSLAEERGVSLVELNQQAESDDQIDRDLDRRLRS 69
Cdd:pfam13401   7 ILVLTGESGTGKTTLLRRLLEQLPEVRDsvvfvdlpsgtSPKDLLRALLRALGLPLSGRLSKEELLAALQQLLLALAVA 85
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 5-78 7.98e-04

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 37.96  E-value: 7.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822    5 VSGPAGSGKSTLAANLAEELGYD--HVSGGDIFRSLAEERGVSLVELNQQAESD-------DQIDRDLDRRLRSTAREED 75
Cdd:pfam00004   3 LYGPPGTGKTTLAKAVAKELGAPfiEISGSELVSKYVGESEKRLRELFEAAKKLapcvifiDEIDALAGSRGSGGDSESR 82


                  ...
gi 517068822   76 DLV 78
Cdd:pfam00004  83 RVV 85
PRK01184 PRK01184
flagellar hook-basal body complex protein FliE;
1-44 8.78e-04

flagellar hook-basal body complex protein FliE;


Pssm-ID: 234914 [Multi-domain]  Cd Length: 184  Bit Score: 38.39  E-value: 8.78e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 517068822   1 MLITVSGPAGSGKSTlAANLAEELGYDHVSGGDIFRSLAEERGV 44
Cdd:PRK01184   2 KIIGVVGMPGSGKGE-FSKIAREMGIPVVVMGDVIREEVKKRGL 44
PRK13768 PRK13768
GTPase; Provisional
 1-27 1.01e-03

GTPase; Provisional


Pssm-ID: 237498 [Multi-domain]  Cd Length: 253  Bit Score: 38.70  E-value: 1.01e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 517068822   1 MLITVSGPAGSGKSTLAANLA---EELGYD 27
Cdd:PRK13768   3 YIVFFLGTAGSGKTTLTKALSdwlEEQGYD 32
PRK14527 PRK14527
adenylate kinase; Provisional
 7-53 1.13e-03

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 38.23  E-value: 1.13e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 517068822   7 GPAGSGKSTLAANLAEELGYDHVSGGDIFRSLAeERGvslVELNQQA 53
Cdd:PRK14527  13 GPPGAGKGTQAERLAQELGLKKLSTGDILRDHV-ARG---TELGQRA 55
Tmk COG0125
Thymidylate kinase [Nucleotide transport and metabolism]; Thymidylate kinase is part of the ...
 1-137 1.73e-03

Thymidylate kinase [Nucleotide transport and metabolism]; Thymidylate kinase is part of the Pathway/BioSystem: Thymidylate biosynthesis


Pssm-ID: 439895 [Multi-domain]  Cd Length: 206  Bit Score: 37.83  E-value: 1.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822   1 MLITVSGPAGSGKSTLAANLAEEL---GYDHV--------SGGDIFRSLAEERGvslVELNQQAES-----------DDQ 58
Cdd:COG0125    4 KFIVFEGIDGSGKSTQIKLLAEYLearGYDVVltrepggtPLGEAIRELLLGDN---EDMSPRTELllfaadraqhvEEV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822  59 IDRDL--------DRRLRST------AREED-DLVLEsrLAGWMAGD-HADLKLWLDAPLDVRAERIADREEKsvteaRD 122
Cdd:COG0125   81 IRPALaagkivicDRYVDSSlayqggGRGLDlEWIRQ--LNRFATGGlKPDLTILLDVPPEVALARARARGGE-----LD 153

                        170
                 ....*....|....*
gi 517068822 123 etqaRAESEGLRYQE 137
Cdd:COG0125  154 ----RFESEDLEFHE 164
aroK PRK00131
shikimate kinase; Reviewed
 1-29 2.08e-03

shikimate kinase; Reviewed


Pssm-ID: 234654 [Multi-domain]  Cd Length: 175  Bit Score: 37.09  E-value: 2.08e-03
                         10        20
                 ....*....|....*....|....*....
gi 517068822   1 MLITVSGPAGSGKSTLAANLAEELGYDHV 29
Cdd:PRK00131   5 PNIVLIGFMGAGKSTIGRLLAKRLGYDFI 33
PRK14530 PRK14530
adenylate kinase; Provisional
 3-37 2.38e-03

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 37.46  E-value: 2.38e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 517068822   3 ITVSGPAGSGKSTLAANLAEELGYDHVSGGDIFRS 37
Cdd:PRK14530   6 ILLLGAPGAGKGTQSSNLAEEFGVEHVTTGDALRA 40
ExeA COG3267
Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, ...
 2-73 2.90e-03

Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 442498 [Multi-domain]  Cd Length: 261  Bit Score: 37.46  E-value: 2.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822   2 LITVSGPAGSGKSTLAANLAEELGYD---------HVSGGDIFRSLAEERGVSLvelnqQAESDDQIDRDLDRRLRSTAR 72
Cdd:COG3267   45 FVVLTGEVGTGKTTLLRRLLERLPDDvkvayipnpQLSPAELLRAIADELGLEP-----KGASKADLLRQLQEFLLELAA 119


                 .
gi 517068822  73 E 73
Cdd:COG3267  120 A 120
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 2-141 4.21e-03

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 36.72  E-value: 4.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822    2 LITVSGPAGSGKSTLAANLAEELGYDHVSGGDIFR---SLAEERGVSLVELNQQAE---SDDQIDRDLDRRLRSTAREED 75
Cdd:TIGR01360   5 IIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRaevASGSERGKQLQAIMESGDlvpLDTVLDLLKDAMVAALGTSKG 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822   76 DLV------------LESRLAgwmagdHADLKLWLDAPLDVRAERIADREEKS--------VTEARDETQARAESEGLRY 135
Cdd:TIGR01360  85 FLIdgyprevkqgeeFERRIG------PPTLVLYFDCSEDTMVKRLLKRAETSgrvddnekTIKKRLETYYKATEPVIAY 158


                  ....*.
gi 517068822  136 QEYYGI 141
Cdd:TIGR01360 159 YETKGK 164
COG4639 COG4639
Predicted kinase [General function prediction only];
2-135 4.56e-03

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 35.96  E-value: 4.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822   2 LITVSGPAGSGKSTLAANLAEELgydHVSGGDIFRSLaeergVSLVELNQQAESD--DQIDRDLDRRLRS---------- 69
Cdd:COG4639    4 LVVLIGLPGSGKSTFARRLFAPT---EVVSSDDIRAL-----LGGDENDQSAWGDvfQLAHEIARARLRAgrltvvdatn 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 517068822  70 -TAREEDDLVlesRLAgwmAGDHADLK-LWLDAPLDVRAERIADReEKSVTEARDETQAR------AESEGLRY 135
Cdd:COG4639   76 lQREARRRLL---ALA---RAYGALVVaVVLDVPLEVCLARNAAR-DRQVPEEVIRRMLRrlrrppLPEEGFRV 142
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 7-80 4.65e-03

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 36.18  E-value: 4.65e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 517068822   7 GPAGSGKSTLAANLAEELGYDhvsggdifrslaeergVSLVELNQQAESDDQIdrdldRRLRSTAREEDDLVLE 80
Cdd:cd19510   30 GPPGTGKSSFIAALAGELDYD----------------ICDLNLSEVVLTDDRL-----NHLLNTAPKQSIILLE 82
PLN02200 PLN02200
adenylate kinase family protein
 1-129 6.82e-03

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 36.02  E-value: 6.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822   1 MLITVSGPaGSGKSTLAANLAEELGYDHVSGGDIFR---SLAEERG----------------VSLVELNQQAESDDQIDR 61
Cdd:PLN02200  45 ITFVLGGP-GSGKGTQCEKIVETFGFKHLSAGDLLRreiASNSEHGamilntikegkivpseVTVKLIQKEMESSDNNKF 123

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 517068822  62 DLDRRLRStarEEDDLVLESrlagwMAGDHADLKLWLDAPLDVRAERIADREEKSVTEARDETQARAE 129
Cdd:PLN02200 124 LIDGFPRT---EENRIAFER-----IIGAEPNVVLFFDCPEEEMVKRVLNRNQGRVDDNIDTIKKRLK 183
PRK13477 PRK13477
bifunctional pantoate--beta-alanine ligase/(d)CMP kinase;
2-46 7.49e-03

bifunctional pantoate--beta-alanine ligase/(d)CMP kinase;


Pssm-ID: 237393 [Multi-domain]  Cd Length: 512  Bit Score: 36.40  E-value: 7.49e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 517068822   2 LITVSGPAGSGKSTLAANLAEELGYDHVSGGDIFRS---LAEERGVSL 46
Cdd:PRK13477 286 IIAIDGPAGAGKSTVTRAVAKKLGLLYLDTGAMYRAvtwLVLQEGIDP 333
HolB COG0470
DNA polymerase III, delta prime subunit [Replication, recombination and repair];
5-73 7.62e-03

DNA polymerase III, delta prime subunit [Replication, recombination and repair];


Pssm-ID: 440238 [Multi-domain]  Cd Length: 289  Bit Score: 36.11  E-value: 7.62e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 517068822   5 VSGPAGSGKSTLAANLAEELGYDHVSGGDIFRSLAEERGVS-----LVELNQQAESD----DQIdRDLDRRLRSTARE 73
Cdd:COG0470   23 LHGPPGIGKTTLALALARDLLCENPEGGKACGQCHSRLMAAgnhpdLLELNPEEKSDqigiDQI-RELGEFLSLTPLE 99
PRK05480 PRK05480
uridine/cytidine kinase; Provisional
 1-30 8.13e-03

uridine/cytidine kinase; Provisional


Pssm-ID: 235492 [Multi-domain]  Cd Length: 209  Bit Score: 35.90  E-value: 8.13e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 517068822   1 MLITVSGPAGSGKSTLAANLAEELGYDHVS 30
Cdd:PRK05480   7 IIIGIAGGSGSGKTTVASTIYEELGDESIA 36
PRK06547 PRK06547
hypothetical protein; Provisional
 1-113 8.37e-03

hypothetical protein; Provisional


Pssm-ID: 235825  Cd Length: 172  Bit Score: 35.49  E-value: 8.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517068822   1 MLITVSGPAGSGKSTLAANLAEELGYDHVSGGDIF---RSLAEerGVSLVelnqqaeSDDQIDRDLDRRLR--------- 68
Cdd:PRK06547  16 ITVLIDGRSGSGKTTLAGALAARTGFQLVHLDDLYpgwHGLAA--ASEHV-------AEAVLDEGRPGRWRwdwannrpg 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 517068822  69 --STAREEDDLVLE------SRLAGWMAGDHADLKLWLDAPLDVRAERIADRE 113
Cdd:PRK06547  87 dwVSVEPGRRLIIEgvgsltAANVALASLLGEVLTVWLDGPEALRKERALARD 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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