|
Name |
Accession |
Description |
Interval |
E-value |
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
615-850 |
2.25e-71 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 234.80 E-value: 2.25e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 615 ALTEKNEALRKADELKNDFVQHVSYELRSPLTNIIGFTDLLRTpGVGPLNERQAEYIDHISTSSSVLLTLVNDILDLATV 694
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLD-EEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 695 DAGIMRLNYADIDLNDLLDDVSMQIADRLHESGVALEITAPAYLGSIIADPQRLKQILLKLLSNAANFSPEGTSISLECH 774
Cdd:COG2205 80 ESGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISAR 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 517055365 775 REGTDFVFSVSDRGPGISPDMIATVFDRFATGAKSGKRGGAGLGLSIVDSFVSLHHGDVTIDSEPGKGTTVVCRIP 850
Cdd:COG2205 160 REGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLP 235
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
576-850 |
1.73e-62 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 214.00 E-value: 1.73e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 576 QGTLELFSGLVLDYAVIPLPNAQTMLTFVNMTDSVRAERALTEKNEALRKADELKNDFVQHVSYELRSPLTNIIGFTDLL 655
Cdd:COG0642 56 LALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELL 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 656 RTPgvgpLNERQAEYIDHISTSSSVLLTLVNDILDLATVDAGIMRLNYADIDLNDLLDDVSMQIADRLHESGVALEITAP 735
Cdd:COG0642 136 LEE----LDEEQREYLETILRSADRLLRLINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLP 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 736 AYLGSIIADPQRLKQILLKLLSNAANFSPEGTSISLECHREGTDFVFSVSDRGPGISPDMIATVFDRFATGAKSGKRGGA 815
Cdd:COG0642 212 DDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGGGT 291
|
250 260 270
....*....|....*....|....*....|....*
gi 517055365 816 GLGLSIVDSFVSLHHGDVTIDSEPGKGTTVVCRIP 850
Cdd:COG0642 292 GLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLP 326
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
569-850 |
2.60e-62 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 215.57 E-value: 2.60e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 569 DDERRSGQGTLELFSGLVLDYAVIPLPNAQTMLTFVNMTDSVRAERALTEkneaLRKADELKNDFVQHVSYELRSPLTNI 648
Cdd:COG5002 108 LALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITE----LERLEQMRREFVANVSHELRTPLTSI 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 649 IGFTDLLRTpGVGPLNERQAEYIDHISTSSSVLLTLVNDILDLATVDAGIMRLNYADIDLNDLLDDVSMQIADRLHESGV 728
Cdd:COG5002 184 RGYLELLLD-GAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGI 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 729 ALEITAPAYLGSIIADPQRLKQILLKLLSNAANFSPEGTSISLECHREGTDFVFSVSDRGPGISPDMIATVFDRFATGAK 808
Cdd:COG5002 263 ELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDK 342
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 517055365 809 SGKR--GGAGLGLSIVDSFVSLHHGDVTIDSEPGKGTTVVCRIP 850
Cdd:COG5002 343 SRSRetGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLP 386
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
477-850 |
3.38e-45 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 168.22 E-value: 3.38e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 477 FENLTEQV-----DLETRYNTLVKVqgetIDHLSEGVAVFGPDGRIRLSNPAFRALWGITETEAKpGTHIRALgeacaps 551
Cdd:COG5000 71 FNRMTDQLkeqreELEERRRYLETI----LENLPAGVIVLDADGRITLANPAAERLLGIPLEELI-GKPLEEL------- 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 552 ydrpDGWKTFAELITSFDDERRSGQGTLELFSGLVLDYAVIPLPNAQTMLTFVNMTDSVRAERaltekNEALRKadelkn 631
Cdd:COG5000 139 ----LPELDLAELLREALERGWQEEIELTRDGRRTLLVRASPLRDDGYVIVFDDITELLRAER-----LAAWGE------ 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 632 dFVQHVSYELRSPLTNIIGFTDLLR---TPGVGPLNERQAEYIDHISTSSSVLLTLVNDILDLATVDAgimrLNYADIDL 708
Cdd:COG5000 204 -LARRIAHEIKNPLTPIQLSAERLRrklADKLEEDREDLERALDTIIRQVDRLKRIVDEFLDFARLPE----PQLEPVDL 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 709 NDLLDDVSMQIADRLHESGVALEITAPAYLGSIIADPQRLKQILLKLLSNAANFSPEGTSISLECHREGTDFVFSVSDRG 788
Cdd:COG5000 279 NELLREVLALYEPALKEKDIRLELDLDPDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNG 358
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 517055365 789 PGISPDMIATVFDRFATgaksGKRGGAGLGLSIVDSFVSLHHGDVTIDSEPGKGTTVVCRIP 850
Cdd:COG5000 359 PGIPEEVLERIFEPFFT----TKPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLP 416
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
476-852 |
8.94e-40 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 153.98 E-value: 8.94e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 476 VFENLTEQVDLE------TRYNTLVkvqgetIDHLSEGVAVFGPDGRIRLSNPAFRALWGITETEAKpGTHIRALGeaca 549
Cdd:COG5809 122 ISRDITERKRMEealresEEKFRLI------FNHSPDGIIVTDLDGRIIYANPAACKLLGISIEELI-GKSILELI---- 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 550 PSYDRPDGWKTFAELITS-------FDDERRSGQGTLELFSGLVLDYAVIplpNAQTMLTFVNMTDSVRAERALtEKNEA 622
Cdd:COG5809 191 HSDDQENVAAFISQLLKDggiaqgeVRFWTKDGRWRLLEASGAPIKKNGE---VDGIVIIFRDITERKKLEELL-RKSEK 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 623 LRKADELkndfVQHVSYELRSPLTNIIGFTDLLRtpgvGPLNERQAEYIDHISTSSSVLLTLVNDILDLATVDAGIMRLN 702
Cdd:COG5809 267 LSVVGEL----AAGIAHEIRNPLTSLKGFIQLLK----DTIDEEQKTYLDIMLSELDRIESIISEFLVLAKPQAIKYEPK 338
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 703 yadidlndLLDDVSMQIADRLH----ESGVALEITAPAYLGSIIADPQRLKQILLKLLSNAANFSPEGTSISLECHREGT 778
Cdd:COG5809 339 --------DLNTLIEEVIPLLQpqalLKNVQIELELEDDIPDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKAEDD 410
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 517055365 779 DFV-FSVSDRGPGISPDMIATVFDRFATGaksgKRGGAGLGLSIVDSFVSLHHGDVTIDSEPGKGTTVVCRIPSV 852
Cdd:COG5809 411 DKVvISVTDEGCGIPEERLKKLGEPFYTT----KEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIK 481
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
501-850 |
4.13e-39 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 149.23 E-value: 4.13e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 501 IDHLSEGVAVFGPDGRIRLSNPAFRALWGITETEAKpGTHIRALGEACAPSYDRPDGWKTFAELITSFDDERRSGQGTLe 580
Cdd:COG3852 13 LDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELL-GRPLAELFPEDSPLRELLERALAEGQPVTEREVTLRRKDGEE- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 581 lfsgLVLDYAVIPLPNAQ----TMLTFVNMTDSVRAERAL--TEKNEALRK-----ADELKNdfvqhvsyelrsPLTNII 649
Cdd:COG3852 91 ----RPVDVSVSPLRDAEgeggVLLVLRDITERKRLERELrrAEKLAAVGElaaglAHEIRN------------PLTGIR 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 650 GFTDLLRTpgvGPLNERQAEYIDHISTSSSVLLTLVNDILDLATVDAGIMRlnyadidlndlldDVSM-QIADRLHE--- 725
Cdd:COG3852 155 GAAQLLER---ELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPRPPERE-------------PVNLhEVLERVLEllr 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 726 ----SGVALEITAPAYLGSIIADPQRLKQILLKLLSNAANFSPEGTSISLECHREGTDF----------VFSVSDRGPGI 791
Cdd:COG3852 219 aeapKNIRIVRDYDPSLPEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVERQVTlgglrprlyvRIEVIDNGPGI 298
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 517055365 792 SPDMIATVFDRFATGaksgKRGGAGLGLSIVDSFVSLHHGDVTIDSEPGKGTTVVCRIP 850
Cdd:COG3852 299 PEEILDRIFEPFFTT----KEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLP 353
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
354-850 |
1.21e-38 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 151.09 E-value: 1.21e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 354 DIEAVRAELERTLKSHAETLDHLATPVAIFDGDRRLQFYNQAFVALWELDIAFLEGRPDNSELLERLRAAKKLPDQLNWK 433
Cdd:COG4251 1 LLLLALLLLLLLLLLLLLLLLLLLLLVLLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 434 SWKEAALSVYRALDTQSDLWHLPNGQTLRVFATAHPQGGATWVFENLTEQVDLETRYNTLVKVQGETIDHLSEGVAVFGP 513
Cdd:COG4251 81 LLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 514 DGRIRLSNPAFRALWGITETEAKPGTHIRALGEACAPSYDRPDGWKTFAELITSFDDERRSGQGTLELFSGLVLDYAVIP 593
Cdd:COG4251 161 LLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 594 LPNAQTMLTFVNMTDSV-----RAERALTEKNEALRKADELKNDFVQHVSYELRSPLTNIIGFTDLLRTPGVGPLNERQA 668
Cdd:COG4251 241 LILLLLLLILVLELLELrleleELEEELEERTAELERSNEELEQFAYVASHDLREPLRKISGFSQLLEEDYGDKLDEEGR 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 669 EYIDHISTSSSVLLTLVNDILDLATVDAGIMRLnyadidlndllDDVSMQ---------IADRLHESGVALEITApayLG 739
Cdd:COG4251 321 EYLERIRDAAERMQALIDDLLAYSRVGRQELEF-----------EPVDLNelleevledLEPRIEERGAEIEVGP---LP 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 740 SIIADPQRLKQILLKLLSNAANFSPEGTS--ISLECHREGTDFVFSVSDRGPGISPDMIATVFDRFATGAKSGKRGGAGL 817
Cdd:COG4251 387 TVRGDPTLLRQVFQNLISNAIKYSRPGEPprIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDEYEGTGI 466
|
490 500 510
....*....|....*....|....*....|...
gi 517055365 818 GLSIVDSFVSLHHGDVTIDSEPGKGTTVVCRIP 850
Cdd:COG4251 467 GLAIVKKIVERHGGRIWVESEPGEGATFYFTLP 499
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
743-850 |
1.76e-34 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 127.38 E-value: 1.76e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 743 ADPQRLKQILLKLLSNAANFSPEGTSISLECHREGTDFVFSVSDRGPGISPDMIATVFDRFATGAK-SGKRGGAGLGLSI 821
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKrSRKIGGTGLGLSI 80
|
90 100
....*....|....*....|....*....
gi 517055365 822 VDSFVSLHHGDVTIDSEPGKGTTVVCRIP 850
Cdd:smart00387 81 VKKLVELHGGEISVESEPGGGTTFTITLP 109
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
612-850 |
1.85e-34 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 142.09 E-value: 1.85e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 612 AER--ALTEKNEALRKADELKNDFVQHVSYELRSPLTNIIGFTDLLRTpgvGPLNERQAEYIDHISTSSSVLLTLVNDIL 689
Cdd:PRK15347 378 AERtqALAEAKQRAEQANKRKSEHLTTISHEIRTPLNGVLGALELLQN---TPLTAEQMDLADTARQCTLSLLAIINNLL 454
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 690 DLATVDAGIMRLNYADIDLNDLLDDVSMQIADRLHESGVALE--ITA--PAYLgsiIADPQRLKQILLKLLSNAANFSPE 765
Cdd:PRK15347 455 DFSRIESGQMTLSLEETALLPLLDQAMLTIQGPAQSKSLTLRtfVGAhvPLYL---HLDSLRLRQILVNLLGNAVKFTET 531
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 766 GtSISLECHREGTDFVFSVSDRGPGISPDMIATVFDRFATgaKSGKRGGAGLGLSIVDSFVSLHHGDVTIDSEPGKGTTV 845
Cdd:PRK15347 532 G-GIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQ--ADTHSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCF 608
|
....*
gi 517055365 846 VCRIP 850
Cdd:PRK15347 609 SLVLP 613
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
748-849 |
1.29e-32 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 121.56 E-value: 1.29e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 748 LKQILLKLLSNAANFSPEGTSISLECHREGTDFVFSVSDRGPGISPDMIATVFDRFATGAKSGKRGGAGLGLSIVDSFVS 827
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREGGGTGLGLAIVRRIVE 80
|
90 100
....*....|....*....|..
gi 517055365 828 LHHGDVTIDSEPGKGTTVVCRI 849
Cdd:cd00075 81 AHGGRITVESEPGGGTTFTVTL 102
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
743-850 |
7.48e-30 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 114.00 E-value: 7.48e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 743 ADPQRLKQILLKLLSNAANFSPEGTSISLECHREGtDFVFSVSDRGPGISPDMIATVFDRFATGAKSgKRGGAGLGLSIV 822
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEGG-ELTLTVEDNGIGIPPEDLPRIFEPFSTADKR-GGGGTGLGLSIV 78
|
90 100
....*....|....*....|....*...
gi 517055365 823 DSFVSLHHGDVTIDSEPGKGTTVVCRIP 850
Cdd:pfam02518 79 RKLVELLGGTITVESEPGGGTTVTLTLP 106
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
748-850 |
8.61e-29 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 111.05 E-value: 8.61e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 748 LKQILLKLLSNAANFSPEGtSISLECHREGTDFV-----FSVSDRGPGISPDMIATVFDRF--ATGAKSGKRGGAGLGLS 820
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEG-EVTLRVSLEEEEEDgvqlrFSVEDTGIGIPEEQQARLFEPFsqADSSTTRKYGGTGLGLA 79
|
90 100 110
....*....|....*....|....*....|
gi 517055365 821 IVDSFVSLHHGDVTIDSEPGKGTTVVCRIP 850
Cdd:cd16922 80 ISKKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
514-850 |
2.07e-28 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 117.59 E-value: 2.07e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 514 DGRIRLSNPAFRALWGITETEAKPGTHIRALGEACAPSYDRPDGWKTFAELITSFDDERRSGQGTLELFSGLVLDYAVIP 593
Cdd:COG4191 10 LLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 594 LPNAQTMLTFVNMTDSVRAERALTEKNEALRKA-DELK---NDFVQH------------VSYELRSPLTNIIGFTDLL-R 656
Cdd:COG4191 90 LEALLLLLLAALDAEENAELEELERDITELERAeEELRelqEQLVQSeklaalgelaagIAHEINNPLAAILGNAELLrR 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 657 TPGVGPLNERQAEYIDHISTSSSVLLTLVNDILDLATVDAGIMR---LNyadidlnDLLDDVSMQIADRLHESGVALEIT 733
Cdd:COG4191 170 RLEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRDEEEREpvdLN-------ELIDEALELLRPRLKARGIEVELD 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 734 APAYLGSIIADPQRLKQILLKLLSNAANFSPEGTS--ISLECHREGTDFVFSVSDRGPGISPDMIATVFDRFATGAKSGK 811
Cdd:COG4191 243 LPPDLPPVLGDPGQLEQVLLNLLINAIDAMEEGEGgrITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFTTKPVGK 322
|
330 340 350
....*....|....*....|....*....|....*....
gi 517055365 812 rgGAGLGLSIVDSFVSLHHGDVTIDSEPGKGTTVVCRIP 850
Cdd:COG4191 323 --GTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLP 359
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
621-850 |
1.61e-26 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 114.17 E-value: 1.61e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 621 EALRKADELKN---DFVQHVSYELRSPLTNIIGFTDLLRTPgvgPLNERQAEYIDHISTSSSVLLTLVNDILDLATVDAG 697
Cdd:PRK11100 244 ESMRVKLEGKAyveQYVQTLTHELKSPLAAIRGAAELLQED---PPPEDRARFTGNILTQSARLQQLIDRLLELARLEQR 320
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 698 IMRLNYADIDLNDLLDDVSMQIADRLHESGVALEITAPAylGSIIADPQRLKQILLKLLSNAANFSPEGTSISLECHREG 777
Cdd:PRK11100 321 QELEVLEPVALAALLEELVEAREAQAAAKGITLRLRPDD--ARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDG 398
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 778 TDFVFSVSDRGPGIsPD-MIATVFDRF------ATGAKSgkrggAGLGLSIVDSFVSLHHGDVTIDSEPGKGTTVVCRIP 850
Cdd:PRK11100 399 EQVALSVEDQGPGI-PDyALPRIFERFyslprpANGRKS-----TGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLP 472
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
491-850 |
3.10e-26 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 114.68 E-value: 3.10e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 491 NTLVKVQGET---IDHLSEGVAVFGPDGRIRLSNPAFRALWGITETEAKpGTHIRALGEACAPSYD-----RPDGWKTFA 562
Cdd:PRK11360 255 QALRETRSLNeliLESIADGVIAIDRQGKITTMNPAAEVITGLQRHELV-GKPYSELFPPNTPFASplldtLEHGTEHVD 333
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 563 ELIT--SFDDERRsgqgtLELFSGLVLDyaviplPNAQTM---LTFVNMTDSVRAERAL--TEKNEALRKadelkndFVQ 635
Cdd:PRK11360 334 LEISfpGRDRTIE-----LSVSTSLLHN------THGEMIgalVIFSDLTERKRLQRRVarQERLAALGE-------LVA 395
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 636 HVSYELRSPLTNIIGFTDLLR-------TPGVGPLNERQAEYIDHIstsssvlltlVNDILDLATVDAGIM---RLNyad 705
Cdd:PRK11360 396 GVAHEIRNPLTAIRGYVQIWRqqtsdppSQEYLSVVLREVDRLNKV----------IDQLLEFSRPRESQWqpvSLN--- 462
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 706 idlnDLLDDVSMQIADRLHESGVALEITAPAYLGSIIADPQRLKQILLKLLSNAANFSPEGTSISLECHREGTDFVF-SV 784
Cdd:PRK11360 463 ----ALVEEVLQLFQTAGVQARVDFETELDNELPPIWADPELLKQVLLNILINAVQAISARGKIRIRTWQYSDGQVAvSI 538
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 517055365 785 SDRGPGISPDMIATVFDRFATGaksgKRGGAGLGLSIVDSFVSLHHGDVTIDSEPGKGTTVVCRIP 850
Cdd:PRK11360 539 EDNGCGIDPELLKKIFDPFFTT----KAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLP 600
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
744-850 |
7.82e-26 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 102.57 E-value: 7.82e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 744 DPQRLKQILLKLLSNAANFSPEGTSISleCHREGTD---FVFSVSDRGPGISPDMIATVFDRFATGAKSG--KRGGAGLG 818
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIR--CILEKFRlnrFLLTVSDSGPGIPPNLREEIFERFRQGDGSStrAHGGTGLG 78
|
90 100 110
....*....|....*....|....*....|..
gi 517055365 819 LSIVDSFVSLHHGDVTIDSEPGKGTTVVCRIP 850
Cdd:cd16925 79 LSIVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
614-850 |
1.41e-25 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 113.79 E-value: 1.41e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 614 RALteknEALRkadeLKNDFVQHVSYELRSPLTNIIGFT-DLLRTPgvgpLNERQAEYIDHISTSSSVLLTLVNDILDLA 692
Cdd:PRK11107 285 RAQ----EAAR----IKSEFLANMSHELRTPLNGVIGFTrQTLKTP----LTPTQRDYLQTIERSANNLLAIINDILDFS 352
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 693 TVDAGIMRLNYADIDLNDLLDDVSMQIADRLHESGvaLEIT------APAYLgsiIADPQRLKQILLKLLSNAANFSPEG 766
Cdd:PRK11107 353 KLEAGKLVLENIPFSLRETLDEVVTLLAHSAHEKG--LELTlnidpdVPDNV---IGDPLRLQQIITNLVGNAIKFTESG 427
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 767 T-SISLECHREGTDFV---FSVSDRGPGISPDMIATVFDRF--ATGAKSGKRGGAGLGLSIVDSFVSLHHGDVTIDSEPG 840
Cdd:PRK11107 428 NiDILVELRALSNTKVqleVQIRDTGIGISERQQSQLFQAFrqADASISRRHGGTGLGLVITQKLVNEMGGDISFHSQPN 507
|
250
....*....|
gi 517055365 841 KGTTVVCRIP 850
Cdd:PRK11107 508 RGSTFWFHLP 517
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
625-850 |
1.63e-25 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 113.46 E-value: 1.63e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 625 KADELKNDFVQHVSYELRSPLTNIIGFTDLLRTpgvGPLNERQAEYIDHISTSSSVLLTLVNDILDLATVDAGIMRLNYA 704
Cdd:PRK11466 439 KASQAKSAFLAAMSHEIRTPLYGILGTAQLLAD---NPALNAQRDDLRAITDSGESLLTILNDILDYSAIEAGGKNVSVS 515
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 705 DIDLNDLLDDVS-MQIAD-RLHESGVALEIT-APAYLGSIIADPQRLKQILLKLLSNAANFSPEGtSISLECHREGTDFV 781
Cdd:PRK11466 516 DEPFEPRPLLEStLQLMSgRVKGRPIRLATDiADDLPTALMGDPRRIRQVITNLLSNALRFTDEG-SIVLRSRTDGEQWL 594
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 517055365 782 FSVSDRGPGISPDMIATVFDRFATgaKSGKRGGAGLGLSIVDSFVSLHHGDVTIDSEPGKGTTVVCRIP 850
Cdd:PRK11466 595 VEVEDSGCGIDPAKLAEIFQPFVQ--VSGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLP 661
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
610-850 |
2.73e-25 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 112.76 E-value: 2.73e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 610 VRAERALTEKNEALRKADELKNDFVQHVSYELRSPLTNIIGFTDLLRTPGvgpLNERQAEYIDHISTSSSVLLTLVNDIL 689
Cdd:PRK10841 427 VKMEESLQEMAQAAEQASQSKSMFLATVSHELRTPLYGIIGNLDLLQTKE---LPKGVDRLVTAMNNSSSLLLKIISDIL 503
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 690 DLATVDAGIMRL----------------NYadidlndllddVSMQIADRLH-----ESGVALeitapaylgSIIADPQRL 748
Cdd:PRK10841 504 DFSKIESEQLKIeprefsprevinhitaNY-----------LPLVVKKRLGlycfiEPDVPV---------ALNGDPMRL 563
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 749 KQILLKLLSNAANFSPEGtSISLECHREGTDFVFSVSDRGPGISPDMIATVFDRF---ATGAKSGKRGgAGLGLSIVDSF 825
Cdd:PRK10841 564 QQVISNLLSNAIKFTDTG-CIVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFfqvGTGVQRNFQG-TGLGLAICEKL 641
|
250 260
....*....|....*....|....*
gi 517055365 826 VSLHHGDVTIDSEPGKGTTVVCRIP 850
Cdd:PRK10841 642 INMMDGDISVDSEPGMGSQFTIRIP 666
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
492-850 |
2.31e-23 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 103.39 E-value: 2.31e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 492 TLVKVQGETIDHLSEGVAVFGPDGRIRLSNPAFRALWGITETeakpGTHIRALgeacapsydrpdgwktfaelitsFDDE 571
Cdd:COG3290 81 RLVEEREAVLESIREGVIAVDRDGRITLINDAARRLLGLDAI----GRPIDEV-----------------------LAEV 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 572 RRSGQGTLEL-FSGLVLDYAVIPLPNAQ----TMLTFVNMTDSVRAERALT---EKNEALRKadeLKNDFVQHvsyelrs 643
Cdd:COG3290 134 LETGERDEEIlLNGRVLVVNRVPIRDDGrvvgAVATFRDRTELERLEEELEgvkELAEALRA---QRHDFRNH------- 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 644 pLTNIIGFTDLLRTpgvgplnERQAEYIDHISTSSSVLLTLVNDILDLATVDAgimRLNYAdidlndllddvsmqiADRL 723
Cdd:COG3290 204 -LHTISGLLQLGEY-------DEALEYIDEISEELQELIDSLLSRIGNPVLAA---LLLGK---------------AARA 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 724 HESGVALEITAPAYLGSIIADPQRLKQILLKLLSNA----ANFSPEGTSISLECHREGTDFVFSVSDRGPGISPDMIATV 799
Cdd:COG3290 258 RERGIDLTIDIDSDLPDLPLSDTDLVTILGNLLDNAieavEKLPEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKI 337
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 517055365 800 FDRfatGAKSGKRGGAGLGLSIVDSFVSLHHGDVTIDSEPGKGTTVVCRIP 850
Cdd:COG3290 338 FER---GFSTKLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLP 385
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
632-850 |
2.51e-23 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 104.01 E-value: 2.51e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 632 DFVQHVSYELRSPLTNIIGFTD-LLRTPGVGPlnerqaEYIDHISTSSSVLLTL---VNDILDLATVDAGIMRLNYADID 707
Cdd:TIGR01386 243 QFSADLAHELRTPLTNLLGQTQvALSQPRTGE------EYREVLESNLEELERLsrmVSDMLFLARADNGQLALERVRLD 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 708 LNDLLDDVSMQIADRLHESGVALEITAPaylGSIIADPQRLKQILLKLLSNAANFSPEGTSISLECHREGTDFVFSVSDR 787
Cdd:TIGR01386 317 LAAELAKVAEYFEPLAEERGVRIRVEGE---GLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNP 393
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 517055365 788 GPGISPDMIATVFDRF--ATGAKSGKRGGAGLGLSIVDSFVSLHHGDVTIDSEPGKgTTVVCRIP 850
Cdd:TIGR01386 394 GPGIPPEHLSRLFDRFyrVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDGK-TRFILRFP 457
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
618-861 |
6.09e-22 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 102.12 E-value: 6.09e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 618 EKNEALrKADELKNDFVQHVSYELRSPLTNIIGFTDLLRtpGVGPLNERQAEYIDHISTSSSVLLTLVNDILDLATVDAG 697
Cdd:PRK09959 701 ERNKAI-NATVAKSQFLATMSHEIRTPISSIMGFLELLS--GSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESG 777
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 698 IMRLNYADIDLNDLLDDVSMQIADRLHESGVALEITAP---AYLGSIiaDPQRLKQILLKLLSNAANFSPEGT---SISL 771
Cdd:PRK09959 778 NYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALSCSSTfpdHYLVKI--DPQAFKQVLSNLLSNALKFTTEGAvkiTTSL 855
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 772 eCHREGTDFV--FSVSDRGPGISPDMIATVFDRFATGAKSGKRGGAGLGLSIVDSFVSLHHGDVTIDSEPGKGTTVVCRI 849
Cdd:PRK09959 856 -GHIDDNHAVikMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITI 934
|
250
....*....|..
gi 517055365 850 PSVDVPHSAAAE 861
Cdd:PRK09959 935 PVEISQQVATVE 946
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
355-852 |
1.01e-21 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 99.81 E-value: 1.01e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 355 IEAVRAELERTLKSHAET-LDHLATPVAIFDGDRRLQFYNQAFVALWELDIAFLEGRPDNSELlerlraAKKLPDQLNWK 433
Cdd:COG5805 21 INNEVLRMAIEITEELETiLENLPDAIIAVNREGKVIYINPAMEKLLGYTSEEIIGKTIFDFL------EKEYHYRVKTR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 434 SWKEAALSVYRALDTQsdlWHLpNGQTLRVFATAHPQGG-----ATWVFENLTEQVDLET-------RYNTLvkvqgetI 501
Cdd:COG5805 95 IERLQKGYDVVMIEQI---YCK-DGELIYVEVKLFPIYNqngqaAILALRDITKKKKIEEilqeqeeRLQTL-------I 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 502 DHLSEGVAVFGPDGRIRLSNPAFRALWGItETEAKPGTHIRALGEACAPSydrpdgwkTFAELITSFDDERRSGQGTLEL 581
Cdd:COG5805 164 ENSPDLICVIDTDGRILFINESIERLFGA-PREELIGKNLLELLHPCDKE--------EFKERIESITEVWQEFIIEREI 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 582 --FSGLV--LDYAVIPLPNAQT-----MLTFVNMTDSVRAERALTeKNEALRKADELkndfVQHVSYELRSPLTNIIGFT 652
Cdd:COG5805 235 itKDGRIryFEAVIVPLIDTDGsvkgiLVILRDITEKKEAEELMA-RSEKLSIAGQL----AAGIAHEIRNPLTSIKGFL 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 653 DLLRtpgvgPLNERQAEYIDHISTSSSVLLTLVNDILDLATVDAgimrLNYADIDLNDLLDDVS--MQIADRLHESGVAL 730
Cdd:COG5805 310 QLLQ-----PGIEDKEEYFDIMLSELDRIESIISEFLALAKPQA----VNKEKENINELIQDVVtlLETEAILHNIQIRL 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 731 EITAPAYlgSIIADPQRLKQILLKLLSNAANFSPEGTSISLECHREGTDFVFSVSDRGPGISPDMIATVFDRFATGaksg 810
Cdd:COG5805 381 ELLDEDP--FIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFFTT---- 454
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 517055365 811 KRGGAGLGLSIVDSFVSLHHGDVTIDSEPGKGTTVVCRIPSV 852
Cdd:COG5805 455 KEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPLS 496
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
614-861 |
1.50e-21 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 100.40 E-value: 1.50e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 614 RALTEKN---EALRKADELKNDFVQHVSYELRSPLTNIIGFTDLLRTPgvgPLNERQAEYIDHISTSSSVLLTLVNDILD 690
Cdd:PRK11091 264 RDITERKryqDALEKASRDKTTFISTISHELRTPLNGIVGLSRILLDT---ELTAEQRKYLKTIHVSAITLGNIFNDIID 340
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 691 LATVDAGIMRLnyadidlndLLDDVSMQ--IADRLHESGV---------ALEITA--PAYlgsIIADPQRLKQILLKLLS 757
Cdd:PRK11091 341 MDKMERRKLQL---------DNQPIDFTdfLADLENLSGLqaeqkglrfDLEPLLplPHK---VITDGTRLRQILWNLIS 408
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 758 NAANFSPEGtSISLECHRE-GTDFVFSVSDRGPGISPDMIATVFDRF--ATGAKSGKRG-GAGLGLSIVDSFVSLHHGDV 833
Cdd:PRK11091 409 NAVKFTQQG-GVTVRVRYEeGDMLTFEVEDSGIGIPEDELDKIFAMYyqVKDSHGGKPAtGTGIGLAVSKRLAQAMGGDI 487
|
250 260 270
....*....|....*....|....*....|
gi 517055365 834 TIDSEPGKGT--TVVCRIPSVDVPHSAAAE 861
Cdd:PRK11091 488 TVTSEEGKGScfTLTIHAPAVAEEVEDAFD 517
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
637-850 |
5.81e-20 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 93.70 E-value: 5.81e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 637 VSYELRSPLTNIIGFTDLL--RTPGVG---PLNERQAEYIDHISTSSSVLLTLVN------DILDLATVDAGIMRLnyad 705
Cdd:PRK10364 244 VAHEIRNPLSSIKGLAKYFaeRAPAGGeahQLAQVMAKEADRLNRVVSELLELVKpthlalQAVDLNDLINHSLQL---- 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 706 idlndllddVSMQIADRlhesGVALEITAPAYLGSIIADPQRLKQILLKLLSNAANFSPEGTSISLECHREGTDFVFSVS 785
Cdd:PRK10364 320 ---------VSQDANSR----EIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVT 386
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 517055365 786 DRGPGISPDMIATVFDRFATgaksGKRGGAGLGLSIVDSFVSLHHGDVTIDSEPGKGTTVVCRIP 850
Cdd:PRK10364 387 DSGKGIAADQLEAIFTPYFT----TKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLP 447
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
578-851 |
5.37e-19 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 90.45 E-value: 5.37e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 578 TLELFSGLVLDYAVIPLPNAQTMLTfvnmtdsvraERALTEKN--EALRKadelknDFVQHVSYELRSPLTNIIGFTDLL 655
Cdd:PRK11006 166 TLVLNNGRHLEIRVMPYTEGQLLMV----------ARDVTQMHqlEGARR------NFFANVSHELRTPLTVLQGYLEMM 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 656 RTPG-VGPLNER-------QAEYIDhistsssvllTLVNDILDLATVDAG-IMRLNyaDIDLNDLLDDVSMQIADRLHES 726
Cdd:PRK11006 230 QDQPlEGALREKalhtmreQTQRME----------GLVKQLLTLSKIEAApTIDLN--EKVDVPMMLRVLEREAQTLSQG 297
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 727 GVALEITAPAYLgSIIADPQRLKQILLKLLSNAANFSPEGTSISLECHREGTDFVFSVSDRGPGISPDMIATVFDRF--A 804
Cdd:PRK11006 298 KHTITFEVDNSL-KVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFyrV 376
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 517055365 805 TGAKSGKRGGAGLGLSIVDSFVSLHHGDVTIDSEPGKGTTVVCRIPS 851
Cdd:PRK11006 377 DKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLPE 423
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
748-851 |
1.40e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 81.86 E-value: 1.40e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 748 LKQILLKLLSNAANFSPEGTSISLECHREGTDFVFSVSDRGPGISPDMIATVFDRFATGAKSGKR--GGAGLGLSIVDSF 825
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRntGGTGLGLAIVKHV 80
|
90 100
....*....|....*....|....*.
gi 517055365 826 VSLHHGDVTIDSEPGKGTTVVCRIPS 851
Cdd:cd16952 81 MSRHDARLLIASELGKGSRFTCLFPS 106
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
576-842 |
6.16e-18 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 86.54 E-value: 6.16e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 576 QGTLELFSGLVLDYAVIPLPNAQTMLTFVNMTDSVRAeraLTEKNEALRKADELKNDFVQHVSYELRSPLT--------- 646
Cdd:PRK09303 100 QQEGATYSGLGENLQPSEIDSGRYSQELLQLSDELFV---LRQENETLLEQLKFKDRVLAMLAHDLRTPLTaaslaletl 176
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 647 --NIIGFTDLLRTPGVGPLNE---RQAEYIDHISTsssvlltlvnDILDLATVDAGIMRLNYADIDLNDLLDDVSMQIAD 721
Cdd:PRK09303 177 elGQIDEDTELKPALIEQLQDqarRQLEEIERLIT----------DLLEVGRTRWEALRFNPQKLDLGSLCQEVILELEK 246
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 722 RLHESGVALEITAPAYLGSIIADPQRLKQILLKLLSNAANFSPEGTSISLEC-HREGTDFVFSVSDRGPGISPDMIATVF 800
Cdd:PRK09303 247 RWLAKSLEIQTDIPSDLPSVYADQERIRQVLLNLLDNAIKYTPEGGTITLSMlHRTTQKVQVSICDTGPGIPEEEQERIF 326
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 517055365 801 -DRFATgAKSGKRGGAGLGLSIVDSFVSLHHGDVTIDSEPGKG 842
Cdd:PRK09303 327 eDRVRL-PRDEGTEGYGIGLSVCRRIVRVHYGQIWVDSEPGQG 368
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
744-850 |
7.66e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 79.81 E-value: 7.66e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 744 DPQRLKQILLKLLSNAANFSPEGTSISLECHREGTDFVFSVSDRGPGISPDMIATVFDRFATGAKSGKR--GGAGLGLSI 821
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRasGGSGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 517055365 822 VDSFVSLHHGDVTIDSEPGKGTTVVCRIP 850
Cdd:cd16946 81 CHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
744-845 |
1.85e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 78.99 E-value: 1.85e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 744 DPQRLKQILLKLLSNAANFSPEGTSISLECHREGTDfVFSVSDRGPGISPDMIATVFDRFATGAKSGKrGGAGLGLSIVD 823
Cdd:cd16940 10 DALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGA-VIRVEDNGPGIDEEELEALFERFYRSDGQNY-GGSGLGLSIVK 87
|
90 100
....*....|....*....|..
gi 517055365 824 SFVSLHHGDVTIDSEPGKGTTV 845
Cdd:cd16940 88 RIVELHGGQIFLGNAQGGGLEA 109
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
618-852 |
6.24e-17 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 84.68 E-value: 6.24e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 618 EKNEALRKadelknDFVQHVSYELRSPLTNIIG----FTDLLRTPGVGPLNERQAEyidhISTsssvLLTLVNDILDLAT 693
Cdd:PRK10549 234 EKNEQMRR------DFMADISHELRTPLAVLRGeleaIQDGVRKFTPESVASLQAE----VGT----LTKLVDDLHQLSL 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 694 VDAGIMRLNYADIDLNDLLDDVSMQIADRLHESGVALEITAPAYLgSIIADPQRLKQILLKLLSNAANFSPEGTSISLEC 773
Cdd:PRK10549 300 SDEGALAYRKTPVDLVPLLEVAGGAFRERFASRGLTLQLSLPDSA-TVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISA 378
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 774 HREGTDFVFSVSDRGPGISPDMIATVFDRF--ATGAKSGKRGGAGLGLSIVDSFVSLHHGDVTIDSEPGKGTTVVCRIPS 851
Cdd:PRK10549 379 EQRDKTLRLTFADSAPGVSDEQLQKLFERFyrTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPL 458
|
.
gi 517055365 852 V 852
Cdd:PRK10549 459 E 459
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
594-855 |
1.91e-16 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 84.32 E-value: 1.91e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 594 LPNAQTML-TFVNMTDSVRAERALTEKNEALRKADE---LKNDFVQHVSYELRSPLTNIIGFTDLLRT--PGVGPLNERQ 667
Cdd:PRK10490 624 IPEQQRLLeTFTLLIANALERLTLTASEEQARLASEreqLRNALLAALSHDLRTPLTVLFGQAEILTLdlASEGSPHARQ 703
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 668 AEYI-DHISTSSSvlltLVNDILDLATVDAGIMRLNYADIDLNDLLDDVSMQIADRLHESGVALEITAPAYLgsIIADPQ 746
Cdd:PRK10490 704 ASEIrQQVLNTTR----LVNNLLDMARIQSGGFNLRKEWLTLEEVVGSALQMLEPGLSGHPINLSLPEPLTL--IHVDGP 777
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 747 RLKQILLKLLSNAANFSPEGTSISLECHREGTDFVFSVSDRGPGISPDMIATVFDRFATGAKSGKRGGAGLGLSIVDSFV 826
Cdd:PRK10490 778 LFERVLINLLENAVKYAGAQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESAIPGVGLGLAICRAIV 857
|
250 260
....*....|....*....|....*....
gi 517055365 827 SLHHGDVTIDSEPGKGTTVVCRIPSVDVP 855
Cdd:PRK10490 858 EVHGGTIWAENRPEGGACFRVTLPLETPP 886
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
620-852 |
3.35e-16 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 81.84 E-value: 3.35e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 620 NEALRKADELKNDFVQH------------VSYELRSPLTNIIGFTDLLRTPGvgPLNERQAEYI-------DHISTSSSV 680
Cdd:COG5806 179 IENLIENILLRKELQRAeklevvselaasIAHEVRNPLTVVRGFIQLLQEPE--LSDEKRKQYIrialeelDRAEAIITD 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 681 LLTLVN------DILDLATVdagimrLNYadidlndllddVSMQIADRLHESGVAL--EITAPAYlgsIIADPQRLKQIL 752
Cdd:COG5806 257 YLTFAKpqpeklEKIDVSEE------LEH-----------VIDVLSPYANMNNVEIqtELEPGLY---IEGDRQKLQQCL 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 753 LKLLSNAANFSPEGTSISLECHREGTDFVFSVSDRGPGISPDMIAtvfdRFATGAKSGKRGGAGLGLSIVDSFVSLHHGD 832
Cdd:COG5806 317 INIIKNGIEAMPNGGTLTIDVSIDKNKVIISIKDTGVGMTKEQLE----RLGEPYFSTKEKGTGLGTMVSYRIIEAMNGT 392
|
250 260
....*....|....*....|
gi 517055365 833 VTIDSEPGKGTTVVCRIPSV 852
Cdd:COG5806 393 IRVESEVGKGTTFTITLPLA 412
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
745-844 |
1.78e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 72.84 E-value: 1.78e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 745 PQRLKQILLKLLSNAANFSPEGTSISLECHREGTDFVFSVSDRGPGISPDMIATVFDRFATGAKSGKrgGAGLGLSIVDS 824
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGE--GTGLGLSLSYR 78
|
90 100
....*....|....*....|
gi 517055365 825 FVSLHHGDVTIDSEPGKGTT 844
Cdd:cd16943 79 IIQKHGGTIRVASVPGGGTR 98
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
748-850 |
1.87e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 73.18 E-value: 1.87e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 748 LKQILLKLLSNAANFSPEGTSISLECHRE---------------GTDFVFSVSDRGPGISPDMIATVFDRFATGAKSGKr 812
Cdd:cd16919 1 LELAILNLAVNARDAMPEGGRLTIETSNQrvdadyalnyrdlipGNYVCLEVSDTGSGMPAEVLRRAFEPFFTTKEVGK- 79
|
90 100 110
....*....|....*....|....*....|....*...
gi 517055365 813 gGAGLGLSIVDSFVSLHHGDVTIDSEPGKGTTVVCRIP 850
Cdd:cd16919 80 -GTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
744-842 |
6.69e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 71.34 E-value: 6.69e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 744 DPQRLKQILLKLLSNAANFSPEGTSISLECHREGTDFVFSVSDRGPGISPDMIATVFDRFATGAK--SGKRgGAGLGLSI 821
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRphSGQK-STGLGLAF 79
|
90 100
....*....|....*....|.
gi 517055365 822 VDSFVSLHHGDVTIDSEPGKG 842
Cdd:cd16945 80 VQEVAQLHGGRITLRNRPDGV 100
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
748-850 |
3.89e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 68.96 E-value: 3.89e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 748 LKQILLKLLSNA----ANFSPEGTSISLECHREGTDFV-FSVSDRGPGISPDMIATVFDRFATGAKSgkrgGAGLGLSIV 822
Cdd:cd16920 1 IQQVLINLVRNGieamSEGGCERRELTIRTSPADDRAVtISVKDTGPGIAEEVAGQLFDPFYTTKSE----GLGMGLSIC 76
|
90 100
....*....|....*....|....*...
gi 517055365 823 DSFVSLHHGDVTIDSEPGKGTTVVCRIP 850
Cdd:cd16920 77 RSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
630-697 |
4.77e-14 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 67.62 E-value: 4.77e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 517055365 630 KNDFVQHVSYELRSPLTNIIGFTDLLRTpgvGPLNERQAEYIDHISTSSSVLLTLVNDILDLATVDAG 697
Cdd:pfam00512 2 KSEFLANLSHELRTPLTAIRGYLELLRD---EKLDEEQREYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
748-840 |
1.04e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 67.81 E-value: 1.04e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 748 LKQILLKLLSNAANFSPEG---------TSISLECHREGTDFVFSVS--DRGPGISPDMIATVFDRFATGaksgKRGGAG 816
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGSggeiilrtrTQRQVTLGHPRHRLALRVSviDNGPGIPPDLQDTIFYPMVSG----RENGTG 76
|
90 100
....*....|....*....|....
gi 517055365 817 LGLSIVDSFVSLHHGDVTIDSEPG 840
Cdd:cd16918 77 LGLAIAQNIVSQHGGVIECDSQPG 100
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
630-697 |
1.87e-13 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 65.67 E-value: 1.87e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 517055365 630 KNDFVQHVSYELRSPLTNIIGFTDLLRTpgvGPLNERQAEYIDHISTSSSVLLTLVNDILDLATVDAG 697
Cdd:smart00388 2 KREFLANLSHELRTPLTAIRGYLELLLD---TELSEEQREYLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
587-850 |
2.01e-13 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 73.65 E-value: 2.01e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 587 LDYAVIPLPNAQTMLTFVNMTDsvRAERALTeknealRKADelkndFVQHVSYELRSPLTNIIGFTDLLRTPgvgplNER 666
Cdd:PRK09835 232 LDPQTVPIELEQLVLSFNHMIE--RIEDVFT------RQSN-----FSADIAHEIRTPITNLITQTEIALSQ-----SRS 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 667 QAEYIDHISTS---SSVLLTLVNDILDLATVDAGIMRLNyadidlndlldDVSMQIADRLH-----------ESGVALEI 732
Cdd:PRK09835 294 QKELEDVLYSNleeLTRMAKMVSDMLFLAQADNNQLIPE-----------KKMLDLADEVGkvfdffeawaeERGVELRF 362
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 733 TAPAYLgsIIADPQRLKQILLKLLSNAANFSPEGTSISLECHREGTDFVFSVSDRGPGISPDMIATVFDRFATGAKSGKR 812
Cdd:PRK09835 363 VGDPCQ--VAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQR 440
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 517055365 813 G--GAGLGLSIVDSFVSLHHGDVTIDSEPgKGTTVVCRIP 850
Cdd:PRK09835 441 KgeGSGIGLAIVKSIVVAHKGTVAVTSDA-RGTRFVISLP 479
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
748-842 |
2.94e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 66.33 E-value: 2.94e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 748 LKQILLKLLSNA--ANFSPEGTSISLECHREGTDFVFSVSDRGPGISPDMIATVFDRFATGAKSGKrgGAGLGLSIVDSF 825
Cdd:cd16976 1 IQQVLMNLLQNAldAMGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGK--GTGLGLSISYGI 78
|
90
....*....|....*..
gi 517055365 826 VSLHHGDVTIDSEPGKG 842
Cdd:cd16976 79 VEEHGGRLSVANEEGAG 95
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
633-853 |
4.33e-13 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 71.54 E-value: 4.33e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 633 FVQHVSYELRSPLTNIIGFTDLLR---TPGVGPLNERqaeyIDHISTSSSVLLTLVNDILDLAtvdAGimrlNYADIDLN 709
Cdd:PRK10755 140 FTADVAHELRTPLAGIRLHLELLEkqhHIDVAPLIAR----LDQMMHTVEQLLQLARAGQSFS---SG----HYQTVKLL 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 710 DLLDDVSMQIADRLHES-GVALEITAPAYLGSIIADPQRLKQILLKLLSNAANFSPEGTSISLECHREGTDFVFSVSDRG 788
Cdd:PRK10755 209 EDVILPSQDELSEMLEQrQQTLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVLAVEDEG 288
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 517055365 789 PGISPDMIATV---FDRFATgaksgKRGGAGLGLSIVDSFVSLHHGDVTI-DSEPGKGTTVVCRIPSVD 853
Cdd:PRK10755 289 PGIDESKCGELskaFVRMDS-----RYGGIGLGLSIVSRITQLHHGQFFLqNRQERSGTRAWVWLPKAQ 352
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
744-846 |
4.91e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 66.15 E-value: 4.91e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 744 DPQRLKQILLKLLSNAANFSPEGTSISLECHREGTDFVFSVSDRGPGISPDMIATVFDRFATGaKSGKRGGA--GLGLSI 821
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTG-ENGRNFQEstGMGLYL 80
|
90 100
....*....|....*....|....*.
gi 517055365 822 VDSFV-SLHHGdVTIDSEPGKGTTVV 846
Cdd:cd16948 81 VKKLCdKLGHK-IDVESEVGEGTTFT 105
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
748-850 |
5.57e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 65.81 E-value: 5.57e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 748 LKQILLKLLSNAANFSPEGTS--ISLECHREGTDFVFSVSDRGPGISPDMIATVFDRFATGAKSGKRGGAGLGLSIVDSF 825
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPprIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSREEYEGTGVGLAIVRKI 80
|
90 100
....*....|....*....|....*
gi 517055365 826 VSLHHGDVTIDSEPGKGTTVVCRIP 850
Cdd:cd16921 81 IERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
627-692 |
7.13e-13 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 64.16 E-value: 7.13e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 517055365 627 DELKNDFVQHVSYELRSPLTNIIGFTDLLRTPgvGPLNERQAEYIDHISTSSSVLLTLVNDILDLA 692
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEE--LLDDEEQREYLERIREEAERLLRLINDLLDLS 64
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
666-851 |
7.21e-13 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 72.40 E-value: 7.21e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 666 RQAEYIDHISTSSSVLLTLVNDILDLATVDAGIMRlnyadidlNDLLDDVSMQIADRL---HESGVALEITAPAYLGSII 742
Cdd:PRK13837 484 RAARYIDEIISAGARARLIIDQILAFGRKGERNTK--------PFDLSELVTEIAPLLrvsLPPGVELDFDQDQEPAVVE 555
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 743 ADPQRLKQILLKLLSNAANFSPEGTSISLECHR----------EGT----DFV-FSVSDRGPGISPDMIATVFDRFATGa 807
Cdd:PRK13837 556 GNPAELQQVLMNLCSNAAQAMDGAGRVDISLSRaklrapkvlsHGVlppgRYVlLRVSDTGAGIDEAVLPHIFEPFFTT- 634
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 517055365 808 ksgKRGGAGLGLSIVDSFVSLHHGDVTIDSEPGKGTTVVCRIPS 851
Cdd:PRK13837 635 ---RAGGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLPP 675
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
748-842 |
8.49e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 65.16 E-value: 8.49e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 748 LKQILLKLLSNAANFSpeGTSISLECHREGTDFVFSVSDRGPGISPDMIATVFDRFATGAKSGKRGGAGLGLSIVDSFVS 827
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGTSGTGLGLAIVQRISD 78
|
90
....*....|....*
gi 517055365 828 LHHGDVTIDSEPGKG 842
Cdd:cd16950 79 AHGGSLTLANRAGGG 93
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
513-853 |
1.28e-12 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 71.24 E-value: 1.28e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 513 PDGRIRLSNPAFRALWGITETEAKpGTHIRALGeacAPSYDRpdgwKTFAELITSFDdERRSgqgtlelFSGLVLDYA-- 590
Cdd:PRK13557 51 PDNPIVFANRAFLEMTGYAAEEII-GNNCRFLQ---GPETDR----ATVAEVRDAIA-ERRE-------IATEILNYRkd 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 591 ---------VIPLPNAQTMLT--FVNMTDSVR---AERAL--TEKNEALrkadelkNDFVQHVSYELRSPLTNIIGFTDL 654
Cdd:PRK13557 115 gssfwnalfVSPVYNDAGDLVyfFGSQLDVSRrrdAEDALrqAQKMEAL-------GQLTGGIAHDFNNLLQVMSGYLDV 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 655 LRTPGVGP--LNERQAEYIDHISTSSSVLLTLVNDILDLA---TVDAGIMRLNyadidlndlLDDVSM-QIADRLHESGV 728
Cdd:PRK13557 188 IQAALSHPdaDRGRMARSVENIRAAAERAATLTQQLLAFArkqRLEGRVLNLN---------GLVSGMgELAERTLGDAV 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 729 ALEITAPAYLGSIIADPQRLKQILLKLLSNAANFSPEGTSISLECH---------------REGTDFVFSVSDRGPGISP 793
Cdd:PRK13557 259 TIETDLAPDLWNCRIDPTQAEVALLNVLINARDAMPEGGRVTIRTRnveiededlamyhglPPGRYVSIAVTDTGSGMPP 338
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 794 DMIATVFDRFATGAKSGKrgGAGLGLSIVDSFVSLHHGDVTIDSEPGKGTTVVCRIPSVD 853
Cdd:PRK13557 339 EILARVMDPFFTTKEEGK--GTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFPASD 396
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
748-850 |
1.90e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 64.27 E-value: 1.90e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 748 LKQILLKLLSNAANFSPEgtSISLECHREGTDFVFSVSDRGPGISPDMIATVFDRF--ATGAKSGKRGGAGLGLSIVDSF 825
Cdd:cd16949 1 LARALENVLRNALRYSPS--KILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFyrVDSARDRESGGTGLGLAIAERA 78
|
90 100
....*....|....*....|....*
gi 517055365 826 VSLHHGDVTIDSEPGKGTTVVCRIP 850
Cdd:cd16949 79 IEQHGGKIKASNRKPGGLRVRIWLP 103
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
751-850 |
2.57e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 63.85 E-value: 2.57e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 751 ILLKLLSNAAN-FSPEGTS---ISLECHREGTDFVFSVSDRGPGISPDMIATVFDR-FATGAKSGKrggaGLGLSIVDSF 825
Cdd:cd16915 4 IVGNLIDNALDaLAATGAPnkqVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERgVSTKGQGER----GIGLALVRQS 79
|
90 100
....*....|....*....|....*
gi 517055365 826 VSLHHGDVTIDSEPGKGTTVVCRIP 850
Cdd:cd16915 80 VERLGGSITVESEPGGGTTFSIRIP 104
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
748-850 |
2.75e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 64.13 E-value: 2.75e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 748 LKQILLKLLSNAANFSPEGTS-ISLECHREGTDFVFSVSDRGPGISPDMIATVFDRFATGAKSGKRGG--AGLGLSIVDS 824
Cdd:cd16953 1 LGQVLRNLIGNAISFSPPDTGrITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGqhSGLGLSISRQ 80
|
90 100 110
....*....|....*....|....*....|
gi 517055365 825 FVSLHHGDVTID--SEPG--KGTTVVCRIP 850
Cdd:cd16953 81 IIEAHGGISVAEnhNQPGqvIGARFTVQLP 110
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
748-850 |
7.31e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 62.40 E-value: 7.31e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 748 LKQILLKLLSNAANFSPEGTSISLECHREGTDFVFSVSDRGPGISPDMIATVFDRFATGAKSGKRGGAGLGLSIVDSFVS 827
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNTEGAGLGLSIAKAIIE 80
|
90 100
....*....|....*....|...
gi 517055365 828 LHHGDVTIDSEpGKGTTVVCRIP 850
Cdd:cd16923 81 LHGGSASAEYD-DNHDLFKVRLP 102
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
725-853 |
1.76e-11 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 67.24 E-value: 1.76e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 725 ESGVALEITA--PAYLGSIIADPQRLKQILLKLLSNAANFspeGTS-ISLECHREGTDFVFSVSDRGPGISPDMIATVFD 801
Cdd:PRK09467 307 ESGYEREIETalQPGPIEVPMNPIAIKRALANLVVNAARY---GNGwIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQ 383
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 517055365 802 RFATGAKSgkRG--GAGLGLSIVDSFVSLHHGDVTIDSEPGKGTTVVCRIPSVD 853
Cdd:PRK09467 384 PFTRGDSA--RGssGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLPLTT 435
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
763-850 |
6.80e-11 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 65.42 E-value: 6.80e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 763 SPEGTSISLECHREGTDFVFSVSDRGPGISPDMIATVFDRFatgakSGKRGGAGLGLSIVDSFVSLHHGD---VTIDSEP 839
Cdd:COG2972 356 KEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-----SSKGEGRGIGLRNVRERLKLYYGEeygLEIESEP 430
|
90
....*....|.
gi 517055365 840 GKGTTVVCRIP 850
Cdd:COG2972 431 GEGTTVTIRIP 441
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
724-860 |
1.46e-10 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 64.24 E-value: 1.46e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 724 HESGVALEITAPAYLGsiIADPQRLKQILLKLLSNAANFSPEGTSISLEchREGTDFVFSVSDRGPGISPDMIATVFDRF 803
Cdd:PRK10604 298 PEKTVRLDTPHQGDYG--ALDMRLMERVLDNLLNNALRYAHSRVRVSLL--LDGNQACLIVEDDGPGIPPEERERVFEPF 373
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 804 ATGAKSGKR--GGAGLGLSIVDSFVSLHHGDVTIDSEPGKGTTVVCRIPSV-DVPHSAAA 860
Cdd:PRK10604 374 VRLDPSRDRatGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWPVWhNLPQFTSA 433
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
744-849 |
2.06e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 58.63 E-value: 2.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 744 DPQRLKQILLKLLSNAANFSPEGTSISLECHREGTDFVFSVSDRGPGISPDMIATVFDRFATGAKSGKRGG-AGLGLSIV 822
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGhYGMGLYIA 80
|
90 100
....*....|....*....|....*..
gi 517055365 823 DSFVSLHHGDVTIDSEPGKGTTVVCRI 849
Cdd:cd16975 81 KNLVEKHGGSLIIENSQKGGAEVTVKI 107
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
633-842 |
6.52e-10 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 62.36 E-value: 6.52e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 633 FVQHVSYELRSPLTNIIGFTDLLRTPGVGPLNERQA-----EYIDHISTsssvlltLVNDILDLATVDAGIMRLNYADID 707
Cdd:PRK10337 240 FTSDAAHELRSPLAALKVQTEVAQLSDDDPQARKKAllqlhAGIDRATR-------LVDQLLTLSRLDSLDNLQDVAEIP 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 708 LNDLLDDVSMQIADRLHESGVALEITAPAYlgSIIADPQRLKQILL--KLLSNAANFSPEGTSISLECHREGtdfvFSVS 785
Cdd:PRK10337 313 LEDLLQSAVMDIYHTAQQAGIDVRLTLNAH--PVIRTGQPLLLSLLvrNLLDNAIRYSPQGSVVDVTLNARN----FTVR 386
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 517055365 786 DRGPGISPDMIATVFDRFATGAKSGKRGgAGLGLSIVDSFVSLHHGDVTIDSEPGKG 842
Cdd:PRK10337 387 DNGPGVTPEALARIGERFYRPPGQEATG-SGLGLSIVRRIAKLHGMNVSFGNAPEGG 442
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
743-843 |
2.71e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 55.98 E-value: 2.71e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 743 ADPQRLKQILLKLLSNAANFSPEGTSISLECHREGTDFVFSVSDRGPGISPDMIATVFDRFATGAKSGKRG--GAGLGLS 820
Cdd:cd16947 16 ANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAkqGNGLGLT 95
|
90 100
....*....|....*....|...
gi 517055365 821 IVDSFVSLHHGDVTIDSEPGKGT 843
Cdd:cd16947 96 ITKRLAESMGGSIYVNSKPYEKT 118
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
744-841 |
5.45e-09 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 58.94 E-value: 5.45e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 744 DPQRLKQILLKLLSNAAN-FSPEGTSISLechREGTDFVFS-------------VSDRGPGISPDMIATVFDRFAtgakS 809
Cdd:PRK11073 234 DPDQIEQVLLNIVRNALQaLGPEGGTITL---RTRTAFQLTlhgeryrlaaridIEDNGPGIPPHLQDTLFYPMV----S 306
|
90 100 110
....*....|....*....|....*....|..
gi 517055365 810 GKRGGAGLGLSIVDSFVSLHHGDVTIDSEPGK 841
Cdd:PRK11073 307 GREGGTGLGLSIARNLIDQHSGKIEFTSWPGH 338
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
722-850 |
1.49e-08 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 58.39 E-value: 1.49e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 722 RLHESGVALEITAPAYLGSIiADPQR---LKQILLKLLSNA--ANFSPEGTSISLECHREGTDFVFSVSDRGPGISPDMI 796
Cdd:PRK11086 406 RARELGITLIISEDSQLPDS-GDEDQvheLITILGNLIENAleAVGGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEI 484
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 517055365 797 ATVFDR-FATgaksgKRGGAGLGLSIVDSFVSLHHGDVTIDSEPGKGTTVVCRIP 850
Cdd:PRK11086 485 DAIFDKgYST-----KGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIP 534
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
748-850 |
9.40e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 50.89 E-value: 9.40e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 748 LKQILLKLLSNAANFSPEGTSISLEChrEGTDFVFSVSDRGPGISPDMIATVFDRFATGAKSGKR--GGAGLGLSIVDSF 825
Cdd:cd16939 1 MARALDNLLRNALRYAHRTVRIALLV--SGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRatGGFGLGLAIVHRV 78
|
90 100
....*....|....*....|....*
gi 517055365 826 VSLHHGDVTIDSEPGKGTTVVCRIP 850
Cdd:cd16939 79 ALWHGGHVECDDSELGGACFRLTWP 103
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
637-850 |
1.08e-07 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 55.32 E-value: 1.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 637 VSYELRSPLTNIIGFTDLLRtpgvgplnERQAEY--IDHISTSSSVLLTLVNDILDLATvdagiMRLNYADIDLNDLLDD 714
Cdd:PRK09470 250 ISHELRTPLTRLQLATALLR--------RRQGESkeLERIETEAQRLDSMINDLLVLSR-----NQQKNHLERETFKANS 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 715 VSMQIAD----RLHESGVALEITAPAYLGSIIADPQRLKQILLKLLSNAANFSPEGTSISLECHRegTDFVFSVSDRGPG 790
Cdd:PRK09470 317 LWSEVLEdakfEAEQMGKSLTVSAPPGPWPINGNPNALASALENIVRNALRYSHTKIEVAFSVDK--DGLTITVDDDGPG 394
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 517055365 791 ISPDMIATVFDRF--ATGAKSGKRGGAGLGLSIVDSFVSLHHGDVTIDSEPGKGTTVVCRIP 850
Cdd:PRK09470 395 VPEEEREQIFRPFyrVDEARDRESGGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLP 456
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
755-850 |
3.82e-07 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 49.91 E-value: 3.82e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 755 LLSNA---ANFSPEGTSISLECHREGTDFVFSVSDRGPGISPDMIATVFDRFATGaksgkrggaGLGLSIVDSFVSlhhg 831
Cdd:COG2172 42 AVTNAvrhAYGGDPDGPVEVELELDPDGLEIEVRDEGPGFDPEDLPDPYSTLAEG---------GRGLFLIRRLMD---- 108
|
90
....*....|....*....
gi 517055365 832 DVTIDSEPGkGTTVVCRIP 850
Cdd:COG2172 109 EVEYESDPG-GTTVRLVKR 126
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
243-487 |
5.62e-07 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 51.95 E-value: 5.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 243 ERDRLMTSISAFQTMLDAIDMPAWQRDPVGRLTWVNQAYgEAVEARSPQQAINEGREMLTT-----VARERIRATTTPES 317
Cdd:COG2202 2 AEEALEESERRLRALVESSPDAIIITDLDGRILYVNPAF-ERLTGYSAEELLGKTLRDLLPpedddEFLELLRAALAGGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 318 PFHDKIsTVVHGNRTFFDVVDVRVP--------GGSAGIAIDVSDIEAVRAELERTLKSHAETLDHLATPVAIFDGDRRL 389
Cdd:COG2202 81 VWRGEL-RNRRKDGSLFWVELSISPvrdedgeiTGFVGIARDITERKRAEEALRESEERLRLLVENAPDGIFVLDLDGRI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 390 QFYNQAFVALWELDIAFLEGRPDNSELLERLRAAKKLPDQLNWKSWKEAALSVYRALDTQSDLWHLPNgqTLRVFATAHP 469
Cdd:COG2202 160 LYVNPAAEELLGYSPEELLGKSLLDLLHPEDRERLLELLRRLLEGGRESYELELRLKDGDGRWVWVEA--SAVPLRDGGE 237
|
250
....*....|....*...
gi 517055365 470 QGGATWVFENLTEQVDLE 487
Cdd:COG2202 238 VIGVLGIVRDITERKRAE 255
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
741-846 |
6.49e-07 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 53.15 E-value: 6.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 741 IIADPQRLKQILLKLLSNAANFSPEGTSISLECHREGTDFVFSVSDRGPGISpdmiatVFDRFATGAKSGKRGGAGLGLS 820
Cdd:COG4192 537 VQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGWP------LVDKLFTPFTTTKEVGLGLGLS 610
|
90 100
....*....|....*....|....*.
gi 517055365 821 IVDSFVSLHHGDVTIDSEPGKGTTVV 846
Cdd:COG4192 611 ICRSIMQQFGGDLYLASTLERGAMVI 636
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
359-616 |
7.31e-07 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 51.56 E-value: 7.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 359 RAELERTLKSHAETLDHLATPVAIFDGDRRLQFYNQAFVALWELDIAFLEGRPdnsellerlraakklPDQLNWKSWKEA 438
Cdd:COG2202 3 EEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKT---------------LRDLLPPEDDDE 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 439 ALSVYRALDTQSDLWHL------PNGQTLRVFATAHP----QG---GATWVFENLTEQV-------DLETRYNTLVkvqg 498
Cdd:COG2202 68 FLELLRAALAGGGVWRGelrnrrKDGSLFWVELSISPvrdeDGeitGFVGIARDITERKraeealrESEERLRLLV---- 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 499 etiDHLSEGVAVFGPDGRIRLSNPAFRALWGITETEAKpGTHIRALGEACAPSYDRPDGWKTFAELITSFDDERRSGQGT 578
Cdd:COG2202 144 ---ENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELL-GKSLLDLLHPEDRERLLELLRRLLEGGRESYELELRLKDGD 219
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 517055365 579 LELFsglVLDYAVIPLPNAQT----MLTFVNMTDSVRAERAL 616
Cdd:COG2202 220 GRWV---WVEASAVPLRDGGEvigvLGIVRDITERKRAEEAL 258
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
750-850 |
8.93e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 47.55 E-value: 8.93e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 750 QILLKLLSNAANFSPeGTSISLECHREGTDFVFSVSDRGPGISPDmiatvfdrfatgaksGKRGGAGLGLSIVDSFVSLH 829
Cdd:cd16917 3 RIVQEALTNALKHAG-ASRVRVTLSYTADELTLTVVDDGVGFDGP---------------APPGGGGFGLLGMRERAELL 66
|
90 100
....*....|....*....|.
gi 517055365 830 HGDVTIDSEPGKGTTVVCRIP 850
Cdd:cd16917 67 GGTLTIGSRPGGGTRVTARLP 87
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
744-850 |
1.34e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 47.53 E-value: 1.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 744 DPQRLKQILLKLLSNAANF-------SPEGTsISLECHREGtDFVFSVSDRGPGISPDMIATVFDRFATGaksgKRGGAG 816
Cdd:cd16944 1 DTTQISQVLTNILKNAAEAiegrpsdVGEVR-IRVEADQDG-RIVLIVCDNGKGFPREMRHRATEPYVTT----RPKGTG 74
|
90 100 110
....*....|....*....|....*....|....
gi 517055365 817 LGLSIVDSFVSLHHGDVTIDSEPGKGTTVVCRIP 850
Cdd:cd16944 75 LGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| PAS_7 |
pfam12860 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
501-614 |
1.36e-06 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.
Pssm-ID: 432837 [Multi-domain] Cd Length: 115 Bit Score: 47.92 E-value: 1.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 501 IDHLSEGVAVFGPDGRIRLSNPAFRALWGITETEAKPGTHIRALGEACApsyDRPD-GWKTFAELITSFDDERRSGQGT- 578
Cdd:pfam12860 1 LENMSQGLSVFDADLRLVAWNRRYRELLDLPEDLVQVGVPFEEIIRYNA---ERGEyGPGDVEAHVRRRLAAARAGSPHy 77
|
90 100 110
....*....|....*....|....*....|....*...
gi 517055365 579 --LELFSGLVLDYAVIPLPNAQTMLTFVNMTDSVRAER 614
Cdd:pfam12860 78 feRERPDGRVIEIRGNPLPDGGFVTTFTDITERRRAEE 115
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
719-850 |
1.41e-06 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 50.39 E-value: 1.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 719 IADRLHESGVALEITAPAYLGSIIADPQR-LKQILLKLLSNAANFSPeGTSISLECHREGTDFVFSVSDRGPGISPDmia 797
Cdd:COG4585 133 AERLLRAAGIRVELDVDGDPDRLPPEVELaLYRIVQEALTNALKHAG-ATRVTVTLEVDDGELTLTVRDDGVGFDPE--- 208
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 517055365 798 tvfdrfatgaksgKRGGAGLGLSIVDSFVSLHHGDVTIDSEPGKGTTVVCRIP 850
Cdd:COG4585 209 -------------AAPGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLP 248
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
744-849 |
4.96e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 46.86 E-value: 4.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 744 DPQRLKQILLKLLSNAANFSPEGTSISLecHREGTDFVFSVSDRGPGISPDMIATVFDRfatgaksGKRG-----GAGLG 818
Cdd:cd16954 34 ERNDLMELLGNLLDNACKWCLEFVEVTA--RQTDGGLHLIVDDDGPGVPESQRSKIFQR-------GQRLdeqrpGQGLG 104
|
90 100 110
....*....|....*....|....*....|.
gi 517055365 819 LSIVDSFVSLHHGDVTIDSEPGKGTTVVCRI 849
Cdd:cd16954 105 LAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
722-852 |
7.14e-06 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 49.45 E-value: 7.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 722 RLHESGVALEITAPAYLGSIIA--DPQRLKQILLKLLSNAANFS---PEGTS-ISLECHREGTDFVFSVSDRGPGISPDM 795
Cdd:PRK15053 405 RARELGLKMVIVPGSQLSQLPPglDSTEFAAIVGNLLDNAFEASlrsDEGNKiVELFLSDEGDDVVIEVADQGCGVPESL 484
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 517055365 796 IATVFDRfATGAKSGKRGGAGLGLSIVDSFVSLHHGDVTIDSEPGKGTTVVCRIPSV 852
Cdd:PRK15053 485 RDKIFEQ-GVSTRADEPGEHGIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFIPKV 540
|
|
| HATPase_YehU-like |
cd16956 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
764-850 |
1.08e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.
Pssm-ID: 340432 [Multi-domain] Cd Length: 101 Bit Score: 44.74 E-value: 1.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 764 PEGTSISLECHREGTDFVFSVSDRGPGISPDmiatvfdrfaTGAKSGKRGGAGLGLSIVDS-FVSL--HHGDVTIDSEPG 840
Cdd:cd16956 22 LDGGRVEITARLDGQHLLLEVEDNGGGMDPD----------TLARILIRSSNGLGLNLVDKrLRQAfgNDYGLDIECAPG 91
|
90
....*....|
gi 517055365 841 KGTTVVCRIP 850
Cdd:cd16956 92 EGTRITIRLP 101
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
759-850 |
1.31e-05 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 46.42 E-value: 1.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 759 AANFSPEGTsISLECHREGTDFVFSVSDRGPGISPDMI---------------ATVFDR----------FATGAKSGKRG 813
Cdd:cd16916 63 AAGKPPEGT-ITLRAEHQGNQVVIEVSDDGRGIDREKIrekaierglitadeaATLSDDevlnlifapgFSTAEQVTDVS 141
|
90 100 110
....*....|....*....|....*....|....*..
gi 517055365 814 GAGLGLSIVDSFVSLHHGDVTIDSEPGKGTTVVCRIP 850
Cdd:cd16916 142 GRGVGMDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| PAS_7 |
pfam12860 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
373-484 |
1.72e-05 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.
Pssm-ID: 432837 [Multi-domain] Cd Length: 115 Bit Score: 44.84 E-value: 1.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 373 LDHLATPVAIFDGDRRLQFYNQAFVALWELDIAFLE-GRPdNSELLeRLRAAKKLPDQLNWKSWKEAALSVYRALDTQSD 451
Cdd:pfam12860 1 LENMSQGLSVFDADLRLVAWNRRYRELLDLPEDLVQvGVP-FEEII-RYNAERGEYGPGDVEAHVRRRLAAARAGSPHYF 78
|
90 100 110
....*....|....*....|....*....|....*
gi 517055365 452 LWHLPNGQTLRVFATAHPQGGatWV--FENLTEQV 484
Cdd:pfam12860 79 ERERPDGRVIEIRGNPLPDGG--FVttFTDITERR 111
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
755-850 |
3.33e-05 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 47.21 E-value: 3.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 755 LLSNA---ANFSPEGTSISLECHREGTDFVFSVSDRGPGISPDMIAtvfdrfatgaksgkRGGAGLGLSIVDSFVSLHHG 831
Cdd:COG3920 407 LVTNAlkhAFLSGEGGRIRVSWRREDGRLRLTVSDNGVGLPEDVDP--------------PARKGLGLRLIRALVRQLGG 472
|
90
....*....|....*....
gi 517055365 832 DVTIDSEPgkGTTVVCRIP 850
Cdd:COG3920 473 TLELDRPE--GTRVRITFP 489
|
|
| HATPase_PDK-like |
cd16929 |
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ... |
778-850 |
1.26e-04 |
|
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.
Pssm-ID: 340406 [Multi-domain] Cd Length: 169 Bit Score: 43.48 E-value: 1.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 778 TDFVFSVSDRGPGISPDMIATVFD-RFAT--------------GAKSGKRGGAGLGLSIVDSFVSLHHGDVTIDSEPGKG 842
Cdd:cd16929 82 EDLTIKISDRGGGIPREDLARLFSyMYSTapqpslddfsdlisGTQPSPLAGFGYGLPMSRLYAEYFGGDLDLQSMEGYG 161
|
....*...
gi 517055365 843 TTVVCRIP 850
Cdd:cd16929 162 TDVYIYLK 169
|
|
| HATPase_YpdA-YehU-LytS-like |
cd16924 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
769-850 |
1.40e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340401 [Multi-domain] Cd Length: 103 Bit Score: 41.66 E-value: 1.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 769 ISLECHREGTDFVFSVSDRGPGISPDMIATVfdrfatGAKSGKrgGAGLGLSIVDSFVSLHHGD---VTIDSEPGKGTTV 845
Cdd:cd16924 27 VTISALKEDNHVMIEVEDNGRGIDPKVLNIL------GKKPKE--GNGIGLYNVHQRLILLFGEdygIHIASEPDKGTRI 98
|
....*
gi 517055365 846 VCRIP 850
Cdd:cd16924 99 TFTIP 103
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
755-849 |
2.61e-04 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 40.71 E-value: 2.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 755 LLSNA---ANFSPEGTSISLECHREGTDFVFSVSDRGPGispdmiatvFDRFATGAKSGKRGGAGLGLSIVDSFVSlhhg 831
Cdd:cd16936 8 AVTNAvrhAYRHDGPGPVRLELDLDPDRLRVEVTDSGPG---------FDPLRPADPDAGLREGGRGLALIRALMD---- 74
|
90
....*....|....*...
gi 517055365 832 DVTIDSEPGkGTTVVCRI 849
Cdd:cd16936 75 EVGYRRTPG-GKTVWLEL 91
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
117-265 |
4.55e-04 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 44.14 E-value: 4.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 117 REIRSALSDAQQRISQYQALIADKNRRIVIWDGNARPELLGQlppetgapqdgeflAFGLWLKSRSASELEKAIDRLRDE 196
Cdd:COG4913 238 ERAHEALEDAREQIELLEPIRELAERYAAARERLAELEYLRA--------------ALRLWFAQRRLELLEAELEELRAE 303
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 517055365 197 AQSFDMVVETIRDEILEAQGRV---------SGGRafvrfvALNNLRAELAELRIERDRLMTSISAFQTMLDAIDMPA 265
Cdd:COG4913 304 LARLEAELERLEARLDALREELdeleaqirgNGGD------RLEQLEREIERLERELEERERRRARLEALLAALGLPL 375
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
763-850 |
1.05e-03 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 42.48 E-value: 1.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 763 SPEGTsISLECHREGTDFVFSVSDRGPGISPDMIAtvfdrfatgAKSGKRG----------------------------- 813
Cdd:COG0643 306 PETGT-ITLSAYHEGGRVVIEVSDDGRGLDLEKIR---------AKAIEKGlitaeeaaalsdeellelifapgfstaee 375
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 517055365 814 -----GAGLGLSIVDSFVSLHHGDVTIDSEPGKGTTVVCRIP 850
Cdd:COG0643 376 vtdlsGRGVGMDVVKTNIEALGGTIEIESEPGKGTTFTLRLP 417
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
784-840 |
2.16e-03 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 41.54 E-value: 2.16e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 517055365 784 VSDRGPGISPDMIATVFDRfatgaksGKRG-----GAGLGLSIVDSFVSLHHGDVTI-DSEPG 840
Cdd:PRK10815 413 VEDDGPGIPESKRELIFDR-------GQRAdtlrpGQGLGLSVAREITEQYEGKISAgDSPLG 468
|
|
| HATPase_Phy-like |
cd16932 |
Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana ... |
744-846 |
2.60e-03 |
|
Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana Phytochrome A, B, C, D and E; This family includes the histidine kinase-like ATPase (HATPase) domains of plant red/far-red photoreceptors, the phytochromes, and includes the Arabidopsis thaliana phytochrome family phyA-phyE. Following red light absorption, biologically inactive forms of phytochromes convert to active forms, which rapidly convert back to inactive forms upon far-red light irradiation. Phytochromes can be considered as having an N-terminal photosensory region to which a bilin chromophore is bound, and a C-terminal output region, which includes the HATPase domain represented here, and is involved in dimerization and presumably contributes to relaying the light signal to downstream signaling events.
Pssm-ID: 340409 [Multi-domain] Cd Length: 113 Bit Score: 38.41 E-value: 2.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 744 DPQRLKQILLKLLSNAANF--SPEG-----TSISLECHREGTDFV---FSVSDRGPGISPDMIATVFDRfatgakSGKRG 813
Cdd:cd16932 3 DQIRLQQVLADFLLNAVRFtpSPGGwveikVSPTKKQIGDGVHVIhleFRITHPGQGLPEELVQEMFEE------NQWTT 76
|
90 100 110
....*....|....*....|....*....|...
gi 517055365 814 GAGLGLSIVDSFVSLHHGDVTIDSEPGKGTTVV 846
Cdd:cd16932 77 QEGLGLSISRKLVKLMNGDVRYLREAGRSYFLI 109
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
501-647 |
2.72e-03 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 40.39 E-value: 2.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 501 IDHLSEGVAVFGPDGRIRLSNPAFRALWGITETEAKpGTHIRALGEACAPSYDRPDGWKTFAE-LITSFDDERRSGQGTL 579
Cdd:COG2202 17 VESSPDAIIITDLDGRILYVNPAFERLTGYSAEELL-GKTLRDLLPPEDDDEFLELLRAALAGgGVWRGELRNRRKDGSL 95
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 517055365 580 elfsgLVLDYAVIPLPNAQ-----TMLTFVNMTDSVRAERALTEKNEALRKADELKNDFVQHVSYELRSPLTN 647
Cdd:COG2202 96 -----FWVELSISPVRDEDgeitgFVGIARDITERKRAEEALRESEERLRLLVENAPDGIFVLDLDGRILYVN 163
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
618-850 |
6.40e-03 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 40.30 E-value: 6.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 618 EKNEALRKAdelkndFVQHVSYELRSPLTNIIGFTDLLRTPGVgplNERQAEYIDHISTSSSVLLTLVNDILDLATVDAG 697
Cdd:PRK10618 444 EKNQQARKA------FLQNIGDELKQPLQSLAQLAAQLRQTSD---EEQQQPELDQLAEQSDVLVRLVDNIQLLNMLETQ 514
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 698 IMRLNYADIDLNDLLDDVSMQIADRLHESGVALEI---TAPA--YLGSIIAdpqrLKQILLKLLsnaaNFSPEGTS---I 769
Cdd:PRK10618 515 DWKPEQELFSLQDLIDEVLPEVLPAIKRKGLQLLIhnhLKAEqlRIGDRDA----LRKILLLLL----NYAITTTAygkI 586
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 517055365 770 SLEC----HREGTdFVFSVSDRGPGISPDMIA---------TVFDRFATgaksgkrgGAGLGLSIVDSFVSLHHGDVTID 836
Cdd:PRK10618 587 TLEVdqdeSSPDR-LTIRILDTGAGVSIKELDnlhfpflnqTQGDRYGK--------ASGLTFFLCNQLCRKLGGHLTIK 657
|
250
....*....|....
gi 517055365 837 SEPGKGTTVVCRIP 850
Cdd:PRK10618 658 SREGLGTRYSIHLK 671
|
|
| HATPase_RsbT-like |
cd16934 |
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine ... |
784-849 |
6.78e-03 |
|
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.
Pssm-ID: 340411 [Multi-domain] Cd Length: 117 Bit Score: 37.35 E-value: 6.78e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 517055365 784 VSDRGPGIsPDMIATVFDRFATGaksgkrGGAGLGLSIVDSFVslhhGDVTIDSEPGKGTTVVCRI 849
Cdd:cd16934 63 AVDQGPGI-ADVDEALRDGFSTG------GGLGLGLGGVRRLA----DEFDLHSAPGRGTVVVARK 117
|
|
| |
