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Conserved domains on  [gi|516620774|ref|WP_017995561|]
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3-isopropylmalate dehydrogenase [Rhizobium leguminosarum]

Protein Classification

3-isopropylmalate dehydrogenase( domain architecture ID 10011514)

3-isopropylmalate dehydrogenase catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate

CATH:  3.40.718.10
EC:  1.1.1.85
Gene Symbol:  leuB
Gene Ontology:  GO:0003862|GO:0046872|GO:0051287
SCOP:  4000791

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 5-368 0e+00

3-isopropylmalate dehydrogenase; Provisional


:

Pssm-ID: 234832  Cd Length: 358  Bit Score: 622.12  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774   5 NLFLLPGDGIGPEAMGEVRKIIAYMNEAMNAGFVTDEGLVGGCAYDAHGAAISEADMQKAIAADAVLFGAVGGPKWDSVP 84
Cdd:PRK00772   4 KIAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWDNLP 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774  85 YEVRPEAGLLRLRKDLQLFANLRPAICYPALAAASSLKPELVEGLDILIIRELTGGVYFGEPKEIIDLgNGQKRGIDTQV 164
Cdd:PRK00772  84 PDVRPERGLLALRKELGLFANLRPAKLYPGLADASPLKPEIVAGLDILIVRELTGGIYFGEPRGREGL-GGEERAFDTMV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 165 YDTYEIERIAGVAFEMARTRQNRVCSMEKRNVMKSGVLWNQVVTETHKsKYSDVQLEHMLADAGGMQLVRQPKQFDVIVT 244
Cdd:PRK00772 163 YTREEIERIARVAFELARKRRKKVTSVDKANVLESSRLWREVVTEVAK-EYPDVELSHMYVDNAAMQLVRNPKQFDVIVT 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 245 DNLFGDMLSDVAAMLTGSLGMLPSASLGApdgktgKRKALYEPVHGSAPDIAGKGIANPIAMIASFAMCLRYSFNLVKEA 324
Cdd:PRK00772 242 ENLFGDILSDEAAMLTGSLGMLPSASLGE------SGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEEAA 315

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 516620774 325 DDLEKAIANVLDKGIRTGDIMADGaRQVGTIEMGDAILAEFKTL 368
Cdd:PRK00772 316 DAIEAAVEKVLAQGYRTADIAEGG-GKVSTSEMGDAILAALAEG 358
 
Name Accession Description Interval E-value
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 5-368 0e+00

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 622.12  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774   5 NLFLLPGDGIGPEAMGEVRKIIAYMNEAMNAGFVTDEGLVGGCAYDAHGAAISEADMQKAIAADAVLFGAVGGPKWDSVP 84
Cdd:PRK00772   4 KIAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWDNLP 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774  85 YEVRPEAGLLRLRKDLQLFANLRPAICYPALAAASSLKPELVEGLDILIIRELTGGVYFGEPKEIIDLgNGQKRGIDTQV 164
Cdd:PRK00772  84 PDVRPERGLLALRKELGLFANLRPAKLYPGLADASPLKPEIVAGLDILIVRELTGGIYFGEPRGREGL-GGEERAFDTMV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 165 YDTYEIERIAGVAFEMARTRQNRVCSMEKRNVMKSGVLWNQVVTETHKsKYSDVQLEHMLADAGGMQLVRQPKQFDVIVT 244
Cdd:PRK00772 163 YTREEIERIARVAFELARKRRKKVTSVDKANVLESSRLWREVVTEVAK-EYPDVELSHMYVDNAAMQLVRNPKQFDVIVT 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 245 DNLFGDMLSDVAAMLTGSLGMLPSASLGApdgktgKRKALYEPVHGSAPDIAGKGIANPIAMIASFAMCLRYSFNLVKEA 324
Cdd:PRK00772 242 ENLFGDILSDEAAMLTGSLGMLPSASLGE------SGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEEAA 315

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 516620774 325 DDLEKAIANVLDKGIRTGDIMADGaRQVGTIEMGDAILAEFKTL 368
Cdd:PRK00772 316 DAIEAAVEKVLAQGYRTADIAEGG-GKVSTSEMGDAILAALAEG 358
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 8-364 0e+00

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 506.09  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774   8 LLPGDGIGPEAMGEVRKIIAYMNEAMNAGFVTDEGLVGGCAYDAHGAAISEADMQKAIAADAVLFGAVGGPKWDsvpYEV 87
Cdd:COG0473    6 VLPGDGIGPEVVAAALKVLEAAAERFGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKWD---DGV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774  88 RPEAGLLRLRKDLQLFANLRPAICYPALAaaSSLKPELVEGLDILIIRELTGGVYFGEPKEIiDLGNGQKRGIDTQVYDT 167
Cdd:COG0473   83 RPESGLLALRKELDLYANLRPAKLYPGLP--SPLKPEIVEGIDLVIVRENTEGLYFGIGGRI-GTGTGEEVAIDTRVYTR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 168 YEIERIAGVAFEMARTRQNRVCSMEKRNVMK-SGVLWNQVVTETHKsKYSDVQLEHMLADAGGMQLVRQPKQFDVIVTDN 246
Cdd:COG0473  160 KGIERIARYAFELARKRRKKVTSVDKANVLKlTSGLWREVVREVAK-EYPDVELDHMYVDAAAMQLVRNPEQFDVIVTEN 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 247 LFGDMLSDVAAMLTGSLGMLPSASLGApdgktgKRKALYEPVHGSAPDIAGKGIANPIAMIASFAMCLRYSfNLVKEADD 326
Cdd:COG0473  239 LFGDILSDLAAGLTGSLGLAPSANIGD------EGKALFEPVHGSAPDIAGKGIANPIATILSAAMMLRHL-GEEEAADA 311

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 516620774 327 LEKAIANVLDKGIRTGDIMADgarqVGTIEMGDAILAE 364
Cdd:COG0473  312 IEAAVEKVLAEGVRTPDLGGK----AGTSEMGDAIIAA 345
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
5-361 1.09e-175

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 492.19  E-value: 1.09e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774    5 NLFLLPGDGIGPEAMGEVRKIIAYMNEAMNAGFVTDEGLVGGCAYDAHGAAISEADMQKAIAADAVLFGAVGGPKWDsvP 84
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWD--P 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774   85 YEVRPEAGLLRLRKDLQLFANLRPAICYPALAAASSLKPElVEGLDILIIRELTGGVYFGEPKEIIdlGNGQKRGIDTQV 164
Cdd:pfam00180  79 AGVRPENGLLALRKELGLFANLRPAKVFPPLGDASPLKNE-VEGVDIVIVRELTGGIYFGIEKGIK--GSGNEVAVDTKL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774  165 YDTYEIERIAGVAFEMARTR-QNRVCSMEKRNVMKSGVLWNQVVTETHKSKYSDVQLEHMLADAGGMQLVRQPKQFDVIV 243
Cdd:pfam00180 156 YSRDEIERIARVAFELARKRgRKKVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIV 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774  244 TDNLFGDMLSDVAAMLTGSLGMLPSASLGApdgktgKRKALYEPVHGSAPDIAGKGIANPIAMIASFAMCLRYSFNLVKE 323
Cdd:pfam00180 236 TPNLFGDILSDEASMLTGSLGLLPSASLGA------NGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEDA 309

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 516620774  324 ADDLEKAIANVLDKGIRTGDIMADgARQVGTIEMGDAI 361
Cdd:pfam00180 310 ADKIEAAVLKVLESGIRTGDLAGS-ATYVSTSEFGEAV 346
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 5-361 9.18e-164

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 461.87  E-value: 9.18e-164
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774    5 NLFLLPGDGIGPEAMGEVRKIIAYMNEAMNAGFVTDEGLVGGCAYDAHGAAISEADMQKAIAADAVLFGAVGGPKWDSVP 84
Cdd:TIGR00169   1 KIAVLPGDGIGPEVMAQALKVLKAVAERFGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774   85 YEVRPEAGLLRLRKDLQLFANLRPAICYPALAAASSLKPELVEGLDILIIRELTGGVYFGEPKEIidlgNGQKRGIDTQV 164
Cdd:TIGR00169  81 RDQRPEQGLLKLRKSLDLFANLRPAKVFPGLEDLSPLKEEIAKGVDFVVVRELTGGIYFGEPKGR----EGEGEAWDTEV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774  165 YDTYEIERIAGVAFEMARTRQNRVCSMEKRNVMKSGVLWNQVVTETHKsKYSDVQLEHMLADAGGMQLVRQPKQFDVIVT 244
Cdd:TIGR00169 157 YTVPEIERIARVAFEMARKRRKKVTSVDKANVLESSRLWRKTVEEIAK-EYPDVELEHQYIDNAAMQLVKSPTQFDVVVT 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774  245 DNLFGDMLSDVAAMLTGSLGMLPSASLGapdgktGKRKALYEPVHGSAPDIAGKGIANPIAMIASFAMCLRYSFNLVKEA 324
Cdd:TIGR00169 236 SNLFGDILSDEASVITGSLGMLPSASLG------SDGFGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYSFNLEEAA 309

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 516620774  325 DDLEKAIANVLDKGIRTGDIMADGARQVGTIEMGDAI 361
Cdd:TIGR00169 310 DAIEAAVKKVLAEGYRTPDLGSSATTAVGTAEMGEEL 346
AksF2_Meth NF040626
homoisocitrate dehydrogenase;
5-368 1.58e-77

homoisocitrate dehydrogenase;


Pssm-ID: 468598  Cd Length: 332  Bit Score: 241.95  E-value: 1.58e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774   5 NLFLLPGDGIGPEAMGEVRKIIaymnEAMNAGFVTDEGLVGGCAYDAHGAAISEADMQKAIAADAVLFGAVggpkwDSVP 84
Cdd:NF040626   3 KITVIPGDGIGKEVMEAALYVL----DALDLNFDFIEAEAGRECFKKNGTTIPEETIKIAKKSDATLFGAV-----TSTP 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774  85 YEVRPeagLLRLRKDLQLFANLRPAICYPALaaasslkPELVEGLDILIIRELTGGVYFGEPKEIIDlgngqKRGIDTQV 164
Cdd:NF040626  74 GQKSP---IITLRKELDLYANLRPIKSYEGI-------NCLFKDLDFLIVRENTEGLYSGLEEEYTE-----EKAIAERV 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 165 YDTYEIERIAGVAFEMARTR-QNRVCSMEKRNVMK-SGVLWNQVVTETHKsKYSDVQLEHMLADAGGMQLVRQPKQFDVI 242
Cdd:NF040626 139 ITRKASERICKFAFEYAIKLgRKKVTAVHKANVLKkTDGIFKDTFYKVAK-DYPQIETEDYYVDATAMYLITKPQDFDVI 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 243 VTDNLFGDMLSDVAAMLTGSLGMLPSASLGAPDGktgkrkaLYEPVHGSAPDIAGKGIANPIAMIASFAMCLRYsFNLVK 322
Cdd:NF040626 218 VTTNLFGDILSDEAAGLVGGLGLAPSANIGDKNG-------LFEPVHGSAPDIAGKNIANPIAMILSASMMLDY-LGETY 289

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 516620774 323 EADDLEKAIANVLDKG-IRTGDIMADGArqvgTIEMGDAILAEFKTL 368
Cdd:NF040626 290 EANKLENALEKVLREGkVVTPDLGGNAK----TMEMANEIKKKIEEL 332
AksF_Meth NF040619
homoisocitrate dehydrogenase;
11-361 7.59e-63

homoisocitrate dehydrogenase;


Pssm-ID: 468591  Cd Length: 332  Bit Score: 203.84  E-value: 7.59e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774  11 GDGIGPEAMGEVRKIiayMNEAMNAGFVtdEGLVGGCAYDAHGAAISEADMQKAIAADAVLFGAVGGPKwdsvPYEVRPE 90
Cdd:NF040619   9 GDGIGKEVIPETVRV---LKELGDFEFI--KGEAGLECFKKYGDAIPEETIEKAKECDAILFGAVTTPK----PTELKNK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774  91 ---AGLLRLRKDLQLFANLRPAICYPALaaasslkpELVEGLDILIIRELTGGVYFGepKEIIDLGNgqKRGIDTQVYDT 167
Cdd:NF040619  80 nykSPILTLRKELDLYANVRPINNFGDG--------QDVKNIDFVIIRENTEGLYVG--REYYDEEN--EIAIAERIISK 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 168 YEIERIAGVAFEMA-RTRQNRVCSMEKRNVMK-SGVLWNQVVTETHKsKYSDVQLE--HMLADAGGMQLVRQPKQFDVIV 243
Cdd:NF040619 148 KGSERIIKFAFEYAkKNNRKKVSCIHKANVLRvTDGLFLEIFNEIKK-KYKNFNIEadDYLVDATAMYLIKNPEMFDVIV 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 244 TDNLFGDMLSDVAAMLTGSLGMLPSASLGapdgktgKRKALYEPVHGSAPDIAGKGIANPIAMIASFAMCLRYsFNLVKE 323
Cdd:NF040619 227 TTNLFGDILSDEASGLIGGLGLAPSANIG-------DKKGLFEPVHGSAPDIAGKGIANPIATILSAAMMLDY-LGMKEK 298

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 516620774 324 ADDLEKAIANVLDKGIRTGDIMADgarqVGTIEMGDAI 361
Cdd:NF040619 299 GDLIREAVKKCLENGKVTPDLGGN----LKTKEVTDKI 332
 
Name Accession Description Interval E-value
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 5-368 0e+00

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 622.12  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774   5 NLFLLPGDGIGPEAMGEVRKIIAYMNEAMNAGFVTDEGLVGGCAYDAHGAAISEADMQKAIAADAVLFGAVGGPKWDSVP 84
Cdd:PRK00772   4 KIAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWDNLP 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774  85 YEVRPEAGLLRLRKDLQLFANLRPAICYPALAAASSLKPELVEGLDILIIRELTGGVYFGEPKEIIDLgNGQKRGIDTQV 164
Cdd:PRK00772  84 PDVRPERGLLALRKELGLFANLRPAKLYPGLADASPLKPEIVAGLDILIVRELTGGIYFGEPRGREGL-GGEERAFDTMV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 165 YDTYEIERIAGVAFEMARTRQNRVCSMEKRNVMKSGVLWNQVVTETHKsKYSDVQLEHMLADAGGMQLVRQPKQFDVIVT 244
Cdd:PRK00772 163 YTREEIERIARVAFELARKRRKKVTSVDKANVLESSRLWREVVTEVAK-EYPDVELSHMYVDNAAMQLVRNPKQFDVIVT 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 245 DNLFGDMLSDVAAMLTGSLGMLPSASLGApdgktgKRKALYEPVHGSAPDIAGKGIANPIAMIASFAMCLRYSFNLVKEA 324
Cdd:PRK00772 242 ENLFGDILSDEAAMLTGSLGMLPSASLGE------SGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEEAA 315

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 516620774 325 DDLEKAIANVLDKGIRTGDIMADGaRQVGTIEMGDAILAEFKTL 368
Cdd:PRK00772 316 DAIEAAVEKVLAQGYRTADIAEGG-GKVSTSEMGDAILAALAEG 358
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 8-364 0e+00

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 506.09  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774   8 LLPGDGIGPEAMGEVRKIIAYMNEAMNAGFVTDEGLVGGCAYDAHGAAISEADMQKAIAADAVLFGAVGGPKWDsvpYEV 87
Cdd:COG0473    6 VLPGDGIGPEVVAAALKVLEAAAERFGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKWD---DGV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774  88 RPEAGLLRLRKDLQLFANLRPAICYPALAaaSSLKPELVEGLDILIIRELTGGVYFGEPKEIiDLGNGQKRGIDTQVYDT 167
Cdd:COG0473   83 RPESGLLALRKELDLYANLRPAKLYPGLP--SPLKPEIVEGIDLVIVRENTEGLYFGIGGRI-GTGTGEEVAIDTRVYTR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 168 YEIERIAGVAFEMARTRQNRVCSMEKRNVMK-SGVLWNQVVTETHKsKYSDVQLEHMLADAGGMQLVRQPKQFDVIVTDN 246
Cdd:COG0473  160 KGIERIARYAFELARKRRKKVTSVDKANVLKlTSGLWREVVREVAK-EYPDVELDHMYVDAAAMQLVRNPEQFDVIVTEN 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 247 LFGDMLSDVAAMLTGSLGMLPSASLGApdgktgKRKALYEPVHGSAPDIAGKGIANPIAMIASFAMCLRYSfNLVKEADD 326
Cdd:COG0473  239 LFGDILSDLAAGLTGSLGLAPSANIGD------EGKALFEPVHGSAPDIAGKGIANPIATILSAAMMLRHL-GEEEAADA 311

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 516620774 327 LEKAIANVLDKGIRTGDIMADgarqVGTIEMGDAILAE 364
Cdd:COG0473  312 IEAAVEKVLAEGVRTPDLGGK----AGTSEMGDAIIAA 345
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
5-361 1.09e-175

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 492.19  E-value: 1.09e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774    5 NLFLLPGDGIGPEAMGEVRKIIAYMNEAMNAGFVTDEGLVGGCAYDAHGAAISEADMQKAIAADAVLFGAVGGPKWDsvP 84
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWD--P 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774   85 YEVRPEAGLLRLRKDLQLFANLRPAICYPALAAASSLKPElVEGLDILIIRELTGGVYFGEPKEIIdlGNGQKRGIDTQV 164
Cdd:pfam00180  79 AGVRPENGLLALRKELGLFANLRPAKVFPPLGDASPLKNE-VEGVDIVIVRELTGGIYFGIEKGIK--GSGNEVAVDTKL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774  165 YDTYEIERIAGVAFEMARTR-QNRVCSMEKRNVMKSGVLWNQVVTETHKSKYSDVQLEHMLADAGGMQLVRQPKQFDVIV 243
Cdd:pfam00180 156 YSRDEIERIARVAFELARKRgRKKVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIV 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774  244 TDNLFGDMLSDVAAMLTGSLGMLPSASLGApdgktgKRKALYEPVHGSAPDIAGKGIANPIAMIASFAMCLRYSFNLVKE 323
Cdd:pfam00180 236 TPNLFGDILSDEASMLTGSLGLLPSASLGA------NGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEDA 309

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 516620774  324 ADDLEKAIANVLDKGIRTGDIMADgARQVGTIEMGDAI 361
Cdd:pfam00180 310 ADKIEAAVLKVLESGIRTGDLAGS-ATYVSTSEFGEAV 346
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 5-361 9.18e-164

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 461.87  E-value: 9.18e-164
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774    5 NLFLLPGDGIGPEAMGEVRKIIAYMNEAMNAGFVTDEGLVGGCAYDAHGAAISEADMQKAIAADAVLFGAVGGPKWDSVP 84
Cdd:TIGR00169   1 KIAVLPGDGIGPEVMAQALKVLKAVAERFGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774   85 YEVRPEAGLLRLRKDLQLFANLRPAICYPALAAASSLKPELVEGLDILIIRELTGGVYFGEPKEIidlgNGQKRGIDTQV 164
Cdd:TIGR00169  81 RDQRPEQGLLKLRKSLDLFANLRPAKVFPGLEDLSPLKEEIAKGVDFVVVRELTGGIYFGEPKGR----EGEGEAWDTEV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774  165 YDTYEIERIAGVAFEMARTRQNRVCSMEKRNVMKSGVLWNQVVTETHKsKYSDVQLEHMLADAGGMQLVRQPKQFDVIVT 244
Cdd:TIGR00169 157 YTVPEIERIARVAFEMARKRRKKVTSVDKANVLESSRLWRKTVEEIAK-EYPDVELEHQYIDNAAMQLVKSPTQFDVVVT 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774  245 DNLFGDMLSDVAAMLTGSLGMLPSASLGapdgktGKRKALYEPVHGSAPDIAGKGIANPIAMIASFAMCLRYSFNLVKEA 324
Cdd:TIGR00169 236 SNLFGDILSDEASVITGSLGMLPSASLG------SDGFGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYSFNLEEAA 309

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 516620774  325 DDLEKAIANVLDKGIRTGDIMADGARQVGTIEMGDAI 361
Cdd:TIGR00169 310 DAIEAAVKKVLAEGYRTPDLGSSATTAVGTAEMGEEL 346
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 5-362 8.95e-115

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 339.74  E-value: 8.95e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774   5 NLFLLPGDGIGPEAMGEVRKIIAYMNEAMNAGFVTDEGLVGGCAYDAHGAAISEADMQKAIAADAVLFGAVGGPKWDSVP 84
Cdd:PLN02329  48 NIALLPGDGIGPEVISVAKNVLQKAGSLEGLEFDFQEMPVGGAALDLVGVPLPEETFTAAKQSDAILLGAIGGYKWDKNE 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774  85 YEVRPEAGLLRLRKDLQLFANLRPAICYPALAAASSLKPELVEGLDILIIRELTGGVYFGEPKEIIDLGNGQKRGIDTQV 164
Cdd:PLN02329 128 KHLRPEMALFYLRRDLKVFANLRPATVLPQLVDASTLKKEVAEGVDMMIVRELTGGIYFGEPRGITINENGEEVGVSTEI 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 165 YDTYEIERIAGVAFEMARTRQNRVCSMEKRNVMKSGVLWNQVVTEThKSKYSDVQLEHMLADAGGMQLVRQPKQFDVIVT 244
Cdd:PLN02329 208 YAAHEIDRIARVAFETARKRRGKLCSVDKANVLDASILWRKRVTAL-ASEYPDVELSHMYVDNAAMQLIRDPKQFDTIVT 286

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 245 DNLFGDMLSDVAAMLTGSLGMLPSASLGAPDgktgkrKALYEPVHGSAPDIAGKGIANPIAMIASFAMCLRYSFNLVKEA 324
Cdd:PLN02329 287 NNIFGDILSDEASMITGSIGMLPSASLGESG------PGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAA 360

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 516620774 325 DDLEKAIANVLDKGIRTGDIMADGARQVGTIEMGDAIL 362
Cdd:PLN02329 361 KRIEDAVVDALNKGFRTGDIYSPGNKLVGCKEMGEEVL 398
AksF2_Meth NF040626
homoisocitrate dehydrogenase;
5-368 1.58e-77

homoisocitrate dehydrogenase;


Pssm-ID: 468598  Cd Length: 332  Bit Score: 241.95  E-value: 1.58e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774   5 NLFLLPGDGIGPEAMGEVRKIIaymnEAMNAGFVTDEGLVGGCAYDAHGAAISEADMQKAIAADAVLFGAVggpkwDSVP 84
Cdd:NF040626   3 KITVIPGDGIGKEVMEAALYVL----DALDLNFDFIEAEAGRECFKKNGTTIPEETIKIAKKSDATLFGAV-----TSTP 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774  85 YEVRPeagLLRLRKDLQLFANLRPAICYPALaaasslkPELVEGLDILIIRELTGGVYFGEPKEIIDlgngqKRGIDTQV 164
Cdd:NF040626  74 GQKSP---IITLRKELDLYANLRPIKSYEGI-------NCLFKDLDFLIVRENTEGLYSGLEEEYTE-----EKAIAERV 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 165 YDTYEIERIAGVAFEMARTR-QNRVCSMEKRNVMK-SGVLWNQVVTETHKsKYSDVQLEHMLADAGGMQLVRQPKQFDVI 242
Cdd:NF040626 139 ITRKASERICKFAFEYAIKLgRKKVTAVHKANVLKkTDGIFKDTFYKVAK-DYPQIETEDYYVDATAMYLITKPQDFDVI 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 243 VTDNLFGDMLSDVAAMLTGSLGMLPSASLGAPDGktgkrkaLYEPVHGSAPDIAGKGIANPIAMIASFAMCLRYsFNLVK 322
Cdd:NF040626 218 VTTNLFGDILSDEAAGLVGGLGLAPSANIGDKNG-------LFEPVHGSAPDIAGKNIANPIAMILSASMMLDY-LGETY 289

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 516620774 323 EADDLEKAIANVLDKG-IRTGDIMADGArqvgTIEMGDAILAEFKTL 368
Cdd:NF040626 290 EANKLENALEKVLREGkVVTPDLGGNAK----TMEMANEIKKKIEEL 332
LEU3_arch TIGR02088
isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal ...
 8-362 3.41e-77

isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal decarboxylating dehydrogenases which include the leucine biosynthesis enzyme 3-isopropylmalate dehydrogenase (LeuB, LEU3) and the methanogenic cofactor CoB biosynthesis enzyme isohomocitrate dehydrogenase (AksF). Both of these have been characterized in Methanococcus janaschii. Non-methanogenic archaea have only one hit to this model and presumably this is LeuB, although phylogenetic trees cannot establish which gene is which in the methanogens. The AksF gene is capable of acting on isohomocitrate, iso(homo)2-citrate and iso(homo)3-citrate in the successive elongation cycles of coenzyme B (7-mercaptoheptanoyl-threonine phosphate). This family is closely related to both the LeuB genes found in TIGR00169 and the mitochondrial eukaryotic isocitrate dehydratases found in TIGR00175. All of these are included within the broader subfamily model, pfam00180.


Pssm-ID: 273962  Cd Length: 322  Bit Score: 240.82  E-value: 3.41e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774    8 LLPGDGIGPEAMGEVRKIIaymnEAMNAGFVTDEGLVGGCAYDAHGAAISEADMQKAIAADAVLFGAVGGPKWDSVpyev 87
Cdd:TIGR02088   3 VIPGDGIGPEVIEAAIRIL----NKLGLEIEFIEFEAGDEALKKYGSALPEDTLEEIRKADAILFGAVTTPANPGY---- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774   88 rpEAGLLRLRKDLQLFANLRPAICYPALAAASSLkpelveGLDILIIRELTGGVYFGepKEIIdlgnGQKRGIDTQVYDT 167
Cdd:TIGR02088  75 --KSVIVTLRKELDLYANVRPAKSLPGIPDLYPN------GKDIVIVRENTEGLYAG--FEFG----FSDRAIAIRVITR 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774  168 YEIERIAGVAFEMARTRQNRVCSMEKRNVMKSG-VLWNQVVTETHKSKysDVQLEHMLADAGGMQLVRQPKQFDVIVTDN 246
Cdd:TIGR02088 141 EGSERIARFAFNLAKERNRKVTCVHKANVLKGTdGLFREVCREIAKRY--GVEYRDMYVDSAAMNLVKDPWRFDVIVTTN 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774  247 LFGDMLSDVAAMLTGSLGMLPSASLGapdgktgKRKALYEPVHGSAPDIAGKGIANPIAMIASFAMCLRYsFNLVKEADD 326
Cdd:TIGR02088 219 MFGDILSDLASALAGSLGLAPSANIG-------DRKALFEPVHGSAPDIAGKGIANPTAAILSVAMMLDY-LGELEKGKL 290

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 516620774  327 LEKAIANVLDKGIRTGDIMADGArqvgTIEMGDAIL 362
Cdd:TIGR02088 291 VWEAVEYYIIEGKKTPDLGGTAK----TKEVGDEIA 322
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 8-364 1.54e-69

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 221.16  E-value: 1.54e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774   8 LLPGDGIGPEAMGEVRKIIaymnEAMNAGFVTDEGLVGGCAYDAHGAAISEADMQKAIAADAVLFGAVGgpkwdSVPYEV 87
Cdd:PRK14025   6 VIEGDGIGKEVVPAALHVL----EATGLPFEFVYAEAGDEVFEKTGKALPEETIEAAKEADAVLFGAAG-----ETAADV 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774  88 rpeagLLRLRKDLQLFANLRPAICYPALaaasslkPELVEGLDILIIRELTGGVYFGEPKEIIDLGNGQKRGIDTQVYdt 167
Cdd:PRK14025  77 -----IVKLRRILDTYANVRPVKSYKGV-------KCLYPDIDYVIVRENTEGLYKGIEAEIADGVTVATRVITRKAS-- 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 168 yeiERIAGVAFEMARTRQN-----RVCSMEKRNVMK-SGVLWNQVVTETHKsKYSDVQLEHMLADAGGMQLVRQPKQFDV 241
Cdd:PRK14025 143 ---ERIFRFAFEMAKRRKKmgkegKVTCAHKANVLKkTDGLFKKTFYEVAK-EYPDIKAEDYYVDAMNMYIITRPQTFDV 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 242 IVTDNLFGDMLSDVAAMLTGSLGMLPSASLgapdgktGKRKALYEPVHGSAPDIAGKGIANPIAMIASFAMCLRYsFNLV 321
Cdd:PRK14025 219 VVTSNLFGDILSDGAAGLVGGLGLAPSANI-------GDKYGLFEPVHGSAPDIAGKGIANPTATILTAVLMLRH-LGEN 290

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 516620774 322 KEADDLEKAIANVLDKGIRTGDIMADgarqVGTIEMGDAILAE 364
Cdd:PRK14025 291 EEADKVEKALEEVLALGLTTPDLGGN----LSTMEMAEEVAKR 329
TTC TIGR02089
tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+) ...
 8-363 2.66e-64

tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+)-tartrate as well as a D-malate. These enzymes are closely related to the 3-isopropylmalate and isohomocitrate dehydrogenases found in TIGR00169 and TIGR02088, respectively. [Energy metabolism, Other]


Pssm-ID: 273963  Cd Length: 352  Bit Score: 208.54  E-value: 2.66e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774    8 LLPGDGIGPEAMGEVRKIIAYMnEAMNAGFVTD-EGLVGGCA-YDAHGAAISEADMQKAIAADAVLFGAVGGPKwdSVPY 85
Cdd:TIGR02089   8 AIPGDGIGKEVVAAALQVLEAA-AKRHGGFSLHfTEFPWSCDyYKEHGKMMPEDGLEKLKKFDAIFLGAVGWPA--LVPD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774   86 EVRPEAGLLRLRKDLQLFANLRPAICYPALAaaSSLKPELVEGLDILIIRELTGGVYF--------GEPKEIidlgngqk 157
Cdd:TIGR02089  85 HISLWGLLLKIRREFDQYANVRPAKLLPGVT--SPLRNCGPGDFDFVVVRENSEGEYSgvggrihrGTDEEV-------- 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774  158 rGIDTQVYDTYEIERIAGVAFEMARTRQNRVCSMEKRNVMKSG-VLWNQVVTETHKsKYSDVQLEHMLADAGGMQLVRQP 236
Cdd:TIGR02089 155 -ATQNAIFTRKGVERIMRFAFELAQKRRKHLTSATKSNGIRHSmPFWDEVFAEVAA-EYPDVEWDSYHIDALAARFVLKP 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774  237 KQFDVIVTDNLFGDMLSDVAAMLTGSLGMLPSASLGaPDGKTgkrKALYEPVHGSAPDIAGKGIANPIAMIASFAMCLRY 316
Cdd:TIGR02089 233 ETFDVIVASNLFGDILSDLGAALMGSLGVAPSANIN-PEGKF---PSMFEPVHGSAPDIAGKGIANPIGAIWTAAMMLEH 308

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 516620774  317 sFNLVKEADDLEKAIANVLDKGIRTGDImadgARQVGTIEMGDAILA 363
Cdd:TIGR02089 309 -LGEKEAGAKIMDAIERVTAAGILTPDV----GGKATTSEVTEAVCN 350
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
 5-363 1.14e-63

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 206.32  E-value: 1.14e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774   5 NLFLLPGDGIGPEAMGEVRKIiayMNEAMNAGF---VTDEGLvGGCAYDAHGAAISEADMQKAIAADAVLFGAVGGPkwd 81
Cdd:PRK03437   6 KLAVIPGDGIGPEVVAEALKV---LDAVAAGGPgveTTEYDL-GARRYLRTGETLPDSVLAELRQHDAILLGAIGDP--- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774  82 SVPYEVRPEAGLLRLRKDLQLFANLRPAICYPAlaAASSLKPElvEGLDILIIRELTGGVYFGEpkeiidlGNGQKRG-- 159
Cdd:PRK03437  79 SVPSGVLERGLLLKLRFALDHYVNLRPSKLYPG--VTSPLAGP--GDIDFVVVREGTEGPYTGN-------GGALRVGtp 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 160 ----IDTQVYDTYEIERIAGVAFEMARTRQNR-VCSMEKRNVM-KSGVLWNQVVTETHKsKYSDVQLEHMLADAGGMQLV 233
Cdd:PRK03437 148 hevaTEVSVNTAFGVERVVRDAFERAQKRPRKhLTLVHKTNVLtFAGDLWQRTVDEVAA-EYPDVTVDYQHVDAATIFMV 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 234 RQPKQFDVIVTDNLFGDMLSDVAAMLTGSLGMLPSASLGApdgkTGKRKALYEPVHGSAPDIAGKGIANPIAMIASFAMC 313
Cdd:PRK03437 227 TDPSRFDVIVTDNLFGDIITDLAAAVTGGIGLAASGNINP----TGTNPSMFEPVHGSAPDIAGQGIADPTAAILSVALL 302

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 516620774 314 LRYsFNLVKEADDLEKAIANvldkgirtgDIMADGARQVGTIEMGDAILA 363
Cdd:PRK03437 303 LDH-LGEEDAAARIEAAVEA---------DLAERGKMGRSTAEVGDRIAA 342
AksF_Meth NF040619
homoisocitrate dehydrogenase;
11-361 7.59e-63

homoisocitrate dehydrogenase;


Pssm-ID: 468591  Cd Length: 332  Bit Score: 203.84  E-value: 7.59e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774  11 GDGIGPEAMGEVRKIiayMNEAMNAGFVtdEGLVGGCAYDAHGAAISEADMQKAIAADAVLFGAVGGPKwdsvPYEVRPE 90
Cdd:NF040619   9 GDGIGKEVIPETVRV---LKELGDFEFI--KGEAGLECFKKYGDAIPEETIEKAKECDAILFGAVTTPK----PTELKNK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774  91 ---AGLLRLRKDLQLFANLRPAICYPALaaasslkpELVEGLDILIIRELTGGVYFGepKEIIDLGNgqKRGIDTQVYDT 167
Cdd:NF040619  80 nykSPILTLRKELDLYANVRPINNFGDG--------QDVKNIDFVIIRENTEGLYVG--REYYDEEN--EIAIAERIISK 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 168 YEIERIAGVAFEMA-RTRQNRVCSMEKRNVMK-SGVLWNQVVTETHKsKYSDVQLE--HMLADAGGMQLVRQPKQFDVIV 243
Cdd:NF040619 148 KGSERIIKFAFEYAkKNNRKKVSCIHKANVLRvTDGLFLEIFNEIKK-KYKNFNIEadDYLVDATAMYLIKNPEMFDVIV 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 244 TDNLFGDMLSDVAAMLTGSLGMLPSASLGapdgktgKRKALYEPVHGSAPDIAGKGIANPIAMIASFAMCLRYsFNLVKE 323
Cdd:NF040619 227 TTNLFGDILSDEASGLIGGLGLAPSANIG-------DKKGLFEPVHGSAPDIAGKGIANPIATILSAAMMLDY-LGMKEK 298

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 516620774 324 ADDLEKAIANVLDKGIRTGDIMADgarqVGTIEMGDAI 361
Cdd:NF040619 299 GDLIREAVKKCLENGKVTPDLGGN----LKTKEVTDKI 332
PRK08997 PRK08997
isocitrate dehydrogenase; Provisional
 2-363 2.32e-59

isocitrate dehydrogenase; Provisional


Pssm-ID: 181606  Cd Length: 334  Bit Score: 194.94  E-value: 2.32e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774   2 TARNLFLLPGDGIGPEAMGEVRKIIaymnEAMNAGFVTDEGLVGGCAYDAHGAAISEADM----QKAIAADAVLFGAVGG 77
Cdd:PRK08997   1 MKQTITVIPGDGIGPSIIDATLKIL----DKLGCDFEYEFADAGLTALEKHGELLPQRTLdlieKNKIALKGPLTTPVGE 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774  78 pKWDSVPyevrpeaglLRLRKDLQLFANLRPAICYPALAAAsslkpelVEGLDILIIRELTGGVYFGEPKEIIDLGN-GQ 156
Cdd:PRK08997  77 -GFTSIN---------VTLRKKFDLYANVRPVLSFPGTKAR-------YDNIDIITVRENTEGMYSGEGQTVSEDGEtAE 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 157 KRGIDTQvydtYEIERIAGVAFEMARtRQNR--VCSMEKRNVMKSGV-LWNQVVTETHKsKYSDVQLEHMLADAGGMQLV 233
Cdd:PRK08997 140 ATSIITR----KGAERIVRFAYELAR-KEGRkkVTAVHKANIMKSTSgLFLKVAREVAL-RYPDIEFEEMIVDATCMQLV 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 234 RQPKQFDVIVTDNLFGDMLSDVAAMLTGSLGMLPSASLgapdgktGKRKALYEPVHGSAPDIAGKGIANPIAMIASFAMC 313
Cdd:PRK08997 214 MNPEQFDVIVTTNLFGDILSDLCAGLVGGLGMAPGANI-------GRDAAIFEAVHGSAPDIAGKNLANPTSVILAAIQM 286

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 516620774 314 LRYsFNLVKEADDLEKAIANVLDKGIR-TGDIMADGarqvGTIEMGDAILA 363
Cdd:PRK08997 287 LEY-LGMPDKAERIRKAIVAVIEAGDRtTRDLGGTH----GTTDFTQAVID 332
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
 1-368 3.21e-59

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 195.33  E-value: 3.21e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774   1 MTARNLFLLPGDGIGPEAMGEVRKIIAYMNEAMNAGFVTDEGLVGGCAYD-AHGAAISEADMQKAIAADAVLFGAVGGPK 79
Cdd:PRK08194   1 MKQFKIAVIPGDGVGKEVVPAAVRVLKAVAEVHGGLKFEFTEFPWSCEYYlEHGEMMPEDGLEQLKQFDAIFLGAVGNPK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774  80 WdsVPYEVRPEAGLLRLRKDLQLFANLRPAICYPALaaasslKPELVE--GLDILIIRELTGGVY-------FGEPKEII 150
Cdd:PRK08194  81 L--VPDHISLWGLLIKIRREFEQVINIRPAKQLRGI------KSPLANpkDFDLLVVRENSEGEYsevggriHRGEDEIA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 151 dlgngqkrgIDTQVYDTYEIERIAGVAFEMARTRQNRVCSMEKRN-VMKSGVLWNQVVTETHKSkYSDVQLEHMLADAGG 229
Cdd:PRK08194 153 ---------IQNAVFTRKGTERAMRYAFELAAKRRKHVTSATKSNgIVHSMPFWDEVFQEVGKD-YPEIETDSQHIDALA 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 230 MQLVRQPKQFDVIVTDNLFGDMLSDVAAMLTGSLGMLPSASLGApdgkTGKRKALYEPVHGSAPDIAGKGIANPIAMIAS 309
Cdd:PRK08194 223 AFFVTRPEEFDVIVASNLFGDILTDIGAAIMGSIGIAPAANINV----NGKYPSMFEPVHGSAPDIAGKGIANPIGQIWT 298

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 516620774 310 FAMCLRYsFNLVKEADDLEKAIANVLDKGIRTGDImadGARQvGTIEMGDAILAEFKTL 368
Cdd:PRK08194 299 AKLMLDH-FGEEELGSHLLDVIEDVTEDGIKTPDI---GGRA-TTDEVTDEIISRLKKL 352
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
10-363 1.46e-52

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 181.24  E-value: 1.46e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774  10 PGDGIGPEAMGEVRKIIaymnEAMNAGFVTDEGLVGGCAYDAHGAAiseadmqkAIAADAvlfgavggpkWDSV------ 83
Cdd:PRK09222  11 YGDGIGPEIMEAVLKIL----EAAGAPLEIETIEIGEKVYKKGWTS--------GISPSA----------WESIrrtkvl 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774  84 ---PYEVrPEAGLLR-----LRKDLQLFANLRPAIcypalaaasSLKPeLVE----GLDILIIRELTGGVYfgepkeiid 151
Cdd:PRK09222  69 lkaPITT-PQGGGYKslnvtLRKTLGLYANVRPCV---------SYHP-FVEtkhpNLDVVIIRENEEDLY--------- 128

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 152 lgngqkRGID-TQVYDTYEI---------ERIAGVAFEMARtRQNR--VCSMEKRNVMK-SGVLWNQVVTETHKsKYSDV 218
Cdd:PRK09222 129 ------AGIEhRQTPDVYQClklisrpgsEKIIRYAFEYAR-ANGRkkVTCLTKDNIMKlTDGLFHKVFDEIAK-EYPDI 200

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 219 QLEHMLADAGGMQLVRQPKQFDVIVTDNLFGDMLSDVAAMLTGSLGMLPSASLgapdgktGKRKALYEPVHGSAPDIAGK 298
Cdd:PRK09222 201 EAEHYIVDIGAARLATNPENFDVIVTPNLYGDILSDIAAEISGSVGLAGSANI-------GEEYAMFEAVHGSAPDIAGK 273

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 516620774 299 GIANPIAMIASFAMCLRYsFNLVKEADDLEKAIANVLDKGIRTGDIMADG--ARQVGTIEMGDAILA 363
Cdd:PRK09222 274 NIANPSGLLNAAVMMLVH-IGQFDIAELIENAWLKTLEDGIHTADIYNEGvsKKKVGTKEFAEAVIE 339
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 8-344 6.57e-43

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 153.11  E-value: 6.57e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774   8 LLPGDGIGPEAMGEVRKIIaymnEAMNAGFVTDEGLVGGCAYDAHGAAISEADMqkaiaaDAVLFGAVG--GPKwdSVPY 85
Cdd:PLN00118  46 LFPGDGIGPEIAESVKQVF----TAAGVPIEWEEHYVGTTVDPRTGSFLTWESL------ESVRRNKVGlkGPM--ATPI 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774  86 EVRPEAGLLRLRKDLQLFANLRPAICYPALAAAsslkpelVEGLDILIIRELTGGVYFGEPKEIIdlgngqkRGI--DTQ 163
Cdd:PLN00118 114 GKGHRSLNLTLRKELGLYANVRPCYSLPGYKTR-------YDDVDLVTIRENTEGEYSGLEHQVV-------RGVveSLK 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 164 VYDTYEIERIAGVAFEMARTR-QNRVCSMEKRNVM-KSGVLWNQVVTEThKSKYSDVQLEHMLADAGGMQLVRQPKQFDV 241
Cdd:PLN00118 180 IITRQASLRVAEYAFHYAKTHgRKRVSAIHKANIMkKTDGLFLKCCREV-AEKYPEIVYEEVIIDNCCMMLVKNPALFDV 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 242 IVTDNLFGDMLSDVAAMLTGSLGMLPSASLGApdgktgKRKALYEPVHGSAPDIAGKGIANPIAMIASFAMCLRYsFNLV 321
Cdd:PLN00118 259 LVMPNLYGDIISDLCAGLIGGLGLTPSCNIGE------NGLALAEAVHGSAPDIAGKNLANPTALLLSAVMMLRH-LKLN 331

                        330       340
                 ....*....|....*....|....
gi 516620774 322 KEADDLEKAIANVLDKG-IRTGDI 344
Cdd:PLN00118 332 EQAEQIHNAILNTIAEGkYRTADL 355
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 4-363 6.72e-37

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 136.92  E-value: 6.72e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774   4 RNLFLLPGDGIGPEAMGEVRKIIaymnEAMNAGfVTDEglvggcAYDAHG------AAISEADMQKAIAADAVLFGAVGG 77
Cdd:PLN00123  31 RAVTLIPGDGIGPLVTGAVEQVM----EAMHAP-VYFE------RYEVHGdmkkvpEEVLESIRRNKVCLKGGLATPVGG 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774  78 pkwdsvpyevRPEAGLLRLRKDLQLFANLRPAICYPALaaasslkPELVEGLDILIIRELTGGVYFGEPKEIIDlgngqk 157
Cdd:PLN00123 100 ----------GVSSLNVQLRKELDLFASLVNCFNLPGL-------PTRHENVDIVVIRENTEGEYSGLEHEVVP------ 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 158 rGI--DTQVYDTYEIERIAGVAFEMAR-TRQNRVCSMEKRNVMKSG-VLWNQVVTETHKsKYSDVQLEHMLADAGGMQLV 233
Cdd:PLN00123 157 -GVveSLKVITKFCSERIAKYAFEYAYlNNRKKVTAVHKANIMKLAdGLFLESCREVAK-KYPGIKYNEIIVDNCCMQLV 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 234 RQPKQFDVIVTDNLFGDMLSDVAAMLTGSLGMLPSaslgapdGKTGKRKALYEPVHGSA----PDIAGKGIANPIAMIAS 309
Cdd:PLN00123 235 SKPEQFDVMVTPNLYGNLVANTAAGIAGGTGVMPG-------GNVGADHAVFEQGASAGnvgnEKLVEQKKANPVALLLS 307

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 516620774 310 FAMCLRYsFNLVKEADDLEKAIANVLDKG-IRTGDIMADGARQvgtiEMGDAILA 363
Cdd:PLN00123 308 SAMMLRH-LQFPSFADRLETAVKRVIAEGkYRTKDLGGSSTTQ----EVVDAVIA 357
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 96-367 1.90e-35

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 133.70  E-value: 1.90e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774  96 LRKDLQLFANLRPAICYPALAaaSSLK-PELVeglDILIIRELTGGVYFG--------EPKEIIDLGNGQKR-------- 158
Cdd:COG0538  108 IRQILDLYVCRRPVRYFKGVP--SPVKhPEKV---DIVIFRENTEDIYAGiewkagspEALKLIFFLEDEMGvtvirfpe 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 159 --GIDTQVYDTYEIERIAGVAFEMARTRQNR-VCSMEKRNVMKS--GVL--W----------NQVVTETHKSKYSDVQ-- 219
Cdd:COG0538  183 dsGIGIKPVSDEGTERLVRAAIQYALDNKRKsVTLVHKGNIMKFteGAFkdWgyevaeeefgDKFITEGPWEKYKGPKpa 262

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 220 ----LEHMLADAGGMQLVRQPKQFDVIVTDNLFGDMLSDVAAMLTGSLGMLPSASLGaPDGKtgkrkALYEPVHGSAPDI 295
Cdd:COG0538  263 gkivYKDRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGANIG-DDGG-----AEFEATHGTAPKY 336

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 516620774 296 AGKGIANPIAMIASFAMCLRYsFNLVKEADDLEKAIANVLDKGIRTGDI--MADGARQVGTIEMGDAILAEFKT 367
Cdd:COG0538  337 AGKDSTNPGSLILSGTMMLRH-RGWLEAADLIEKAVEKTIESGKVTYDLarLMEGATELSTSEFGDAIIENLDK 409
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
11-369 1.23e-31

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 123.40  E-value: 1.23e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774  11 GDGIGPEAMGEVRKIIaymNEAMNAGFVTD------EGLVGGCAYDAHGAAISEADMQKAIAADAVLFGAVGGP---KWD 81
Cdd:PRK06451  31 GDGIGPEITHAAMKVI---NKAVEKAYGSDreikwvEVLAGDKAEKLTGNRFPKESEELIEKYRVLLKGPLETPigkGWK 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774  82 SVPyevrpeaglLRLRKDLQLFANLRPAICYPALAaaSSLK-PELVeglDILIIRELTGGVYFG--------EPKEIIDL 152
Cdd:PRK06451 108 SIN---------VAIRLMLDLYANIRPVKYIPGIE--SPLKnPEKI---DLIIFRENTDDLYRGieypydseEAKKIRDF 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 153 GNGQKR-------GIDTQVYDTYEIERIAGVAFEMA-RTRQNRVCSMEKRNVMK--SGVL--W----------NQVVTET 210
Cdd:PRK06451 174 LRKELGveveddtGIGIKLISKFKTQRIARMAIKYAiDHKRKKVTIMHKGNVMKytEGAFreWayevalkefrDYVVTEE 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 211 HKSKYSD-------VQLEHMLADAGGMQLVRQPKQFDVIVTDNLFGDMLSDVAAMLTGSLGMLPSASLgapdGKTGkrkA 283
Cdd:PRK06451 254 EVTKNYNgvppsgkVIINDRIADNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANI----GDTG---G 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 284 LYEPVHGSAPDIAGKGIANPIAMIASFAMCLRYsFNLVKEADDLEKAIANVLDKGIRTGDIMA-DGARQVGTIEMGDAIL 362
Cdd:PRK06451 327 MFEAIHGTAPKYAGKNVANPTGIIKGGELMLRF-MGWDKAADLIDKAIMESIKQKKVTQDLARfMGVRALSTTEYTDELI 405


                 ....*..
gi 516620774 363 AEFKTLS 369
Cdd:PRK06451 406 SIIDMLS 412
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 96-362 2.37e-17

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 82.80  E-value: 2.37e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774  96 LRKDLQLFANLRPAICYPALAaaSSLK-PELVeglDILIIRELTGGVYFG--------EPKEIID-----LGNGQKR--- 158
Cdd:PRK07006 111 LRQELDLYVCLRPVRYFKGVP--SPVKrPEDT---DMVIFRENSEDIYAGiewkagsaEAKKVIKflqeeMGVKKIRfpe 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 159 --GIDTQVYDTYEIERIAGVAFEMARTRQNR-VCSMEKRNVMK--SGVL------------------WNQVVTETHKSKY 215
Cdd:PRK07006 186 tsGIGIKPVSEEGTERLVRAAIEYAIDNDRKsVTLVHKGNIMKftEGAFkdwgyqlaeeefgdelidGGPWDKIKNPETG 265

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 216 SDVQLEHMLADAGGMQLVRQPKQFDVIVTDNLFGDMLSDVAAMLTGSLGMLPSASLGapDGktgkrKALYEPVHGSAPDI 295
Cdd:PRK07006 266 KEIIVKDSIADAFLQQILLRPAEYDVIATMNLNGDYISDALAAQVGGIGIAPGANIN--DG-----HAIFEATHGTAPKY 338

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 516620774 296 AGKGIANPIAMIASFAMCLRY-SFNlvkEADDL-----EKAIANvldkGIRTGDI--MADGARQVGTIEMGDAIL 362
Cdd:PRK07006 339 AGLDKVNPGSVILSAEMMLRHmGWT---EAADLiiksmEKTIAS----KTVTYDFarLMEGATEVKCSEFGDALI 406
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
224-333 1.54e-12

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 68.59  E-value: 1.54e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 224 LADAGGMQLVRQPKQFDVIVTDNLFGDMLSDVAAMLTGSLGMLPSASLgapdgktGKRKALYEPVHGSAPDIAGKGIANP 303
Cdd:PRK07362 338 IADSIFQQIQTRPQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANI-------GDNAAIFEATHGTAPKHAGLDRINP 410

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 516620774 304 IAMIASFAMCLRY-----SFNLVKEAddLEKAIAN 333
Cdd:PRK07362 411 GSVILSGVMMLEYlgwqeAADLITKG--LSAAIAN 443
PRK08299 PRK08299
NADP-dependent isocitrate dehydrogenase;
249-343 7.14e-05

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236226  Cd Length: 402  Bit Score: 44.46  E-value: 7.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 249 GDMLSDVAAMLTGSLGMLPSAsLGAPDGKTGKrkalYEPVHGSAPD-----IAGKGIA-NPIAMIASFAMCLRY------ 316
Cdd:PRK08299 272 GDVQSDTVAQGFGSLGLMTSV-LMTPDGKTVE----AEAAHGTVTRhyrqhQKGEETStNPIASIFAWTRGLAHrgkldg 346

                         90       100
                 ....*....|....*....|....*..
gi 516620774 317 SFNLVKEADDLEKAIANVLDKGIRTGD 343
Cdd:PRK08299 347 NPELVKFADTLEKVCIETVESGFMTKD 373
PdxA COG1995
4-hydroxy-L-threonine phosphate dehydrogenase PdxA [Coenzyme transport and metabolism]; ...
 287-317 2.53e-04

4-hydroxy-L-threonine phosphate dehydrogenase PdxA [Coenzyme transport and metabolism]; 4-hydroxy-L-threonine phosphate dehydrogenase PdxA is part of the Pathway/BioSystem: Pyridoxal phosphate biosynthesis


Pssm-ID: 441598  Cd Length: 330  Bit Score: 42.36  E-value: 2.53e-04
                         10        20        30
                 ....*....|....*....|....*....|.
gi 516620774 287 PVHGSAPDIAGKGIANPIAMIASFAMCLRYS 317
Cdd:COG1995  296 VDHGTAFDIAGKGIADPGSLIAAIRLAARLA 326
PLN03065 PLN03065
isocitrate dehydrogenase (NADP+); Provisional
 144-344 4.72e-04

isocitrate dehydrogenase (NADP+); Provisional


Pssm-ID: 178617 [Multi-domain]  Cd Length: 483  Bit Score: 42.18  E-value: 4.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 144 GEPKEIiDLGNGQKRGIDTQVYDTYE-IERIAGVAFEMARTRQNRVCSMEKRNVMKS-----GVLWNQVVTETHKSKYSD 217
Cdd:PLN03065 232 NAPVEL-DVYDFKGPGVALAMYNVDEsIRAFAESSMAMALQKKWPLYLSTKNTILKKydgrfKDIFQEVYEEQWKQKFEE 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 218 --VQLEHMLADAGGMQLVRQPKQFdVIVTDNLFGDMLSDVAAMLTGSLGMLPSASLgAPDGKTGKRKAlyepVHGSAP-- 293
Cdd:PLN03065 311 hsIWYEHRLIDDMVAYAVKSEGGY-VWACKNYDGDVQSDLLAQGFGSLGLMTSVLL-SSDGKTLEAEA----AHGTVTrh 384

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 516620774 294 -DIAGKGI---ANPIAMIASFAMCLRYSFNLVKEAD------DLEKAIANVLDKGIRTGDI 344
Cdd:PLN03065 385 fRLHQKGQetsTNSIASIFAWTRGLEHRAKLDKNEElldfvhKLESACIETVESGKMTKDL 445
PdxA pfam04166
Pyridoxal phosphate biosynthetic protein PdxA; In Escherichia coli the coenzyme pyridoxal 5 ...
 287-313 5.83e-04

Pyridoxal phosphate biosynthetic protein PdxA; In Escherichia coli the coenzyme pyridoxal 5'-phosphate is synthesized de novo by a pathway that is thought to involve the condensation of 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose, catalyzed by the enzymes PdxA and PdxJ, to form either pyridoxine (vitamin B6) or pyridoxine 5'-phosphate.


Pssm-ID: 461203  Cd Length: 251  Bit Score: 40.83  E-value: 5.83e-04
                          10        20
                  ....*....|....*....|....*..
gi 516620774  287 PVHGSAPDIAGKGIANPIAMIASFAMC 313
Cdd:pfam04166 225 VDHGTAFDIAGKGIADPGSLREAIRLA 251
PTZ00435 PTZ00435
isocitrate dehydrogenase; Provisional
 205-344 6.79e-04

isocitrate dehydrogenase; Provisional


Pssm-ID: 240417  Cd Length: 413  Bit Score: 41.51  E-value: 6.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 205 QVVTETHKSKYSDVQL--EHMLADAGGMQLVRQPKQFdVIVTDNLFGDMLSDVAAMLTGSLGMLPSAsLGAPDGKTGKRK 282
Cdd:PTZ00435 230 EIYDEEYKAKFEKAGLwyEHRLIDDMVAQAIKSEGGF-VWACKNYDGDVQSDIVAQGYGSLGLMTSV-LVCPDGKTVEAE 307

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 283 ALYEPV--HGSAPDIAGKGIANPIAMIASFAMCLRY------SFNLVKEADDLEKAIANVLDKGIRTGDI 344
Cdd:PTZ00435 308 AAHGTVtrHYRQHQKGKETSTNSIASIFAWTRGLAHrakldnNQELVKFCQALERSCIETIEAGFMTKDL 377
pdxA PRK02746
4-hydroxythreonine-4-phosphate dehydrogenase PdxA;
287-308 1.68e-03

4-hydroxythreonine-4-phosphate dehydrogenase PdxA;


Pssm-ID: 235066  Cd Length: 345  Bit Score: 39.89  E-value: 1.68e-03
                         10        20
                 ....*....|....*....|..
gi 516620774 287 PVHGSAPDIAGKGIANPIAMIA 308
Cdd:PRK02746 310 PDHGTAFDIAGKGIARPQSMKA 331
pdxA PRK03743
4-hydroxythreonine-4-phosphate dehydrogenase PdxA;
289-317 5.21e-03

4-hydroxythreonine-4-phosphate dehydrogenase PdxA;


Pssm-ID: 179641  Cd Length: 332  Bit Score: 38.44  E-value: 5.21e-03
                         10        20
                 ....*....|....*....|....*....
gi 516620774 289 HGSAPDIAGKGIANPIAMIASFAMCLRYS 317
Cdd:PRK03743 299 HGTAFDIAGTGKASSVSMEEAILLAAKYA 327
PLN00103 PLN00103
isocitrate dehydrogenase (NADP+); Provisional
 205-367 5.88e-03

isocitrate dehydrogenase (NADP+); Provisional


Pssm-ID: 177720  Cd Length: 410  Bit Score: 38.28  E-value: 5.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 205 QVVTETH-KSKYSDVQL--EHMLADAGGMQLVRQPKQFdVIVTDNLFGDMLSDVAAMLTGSLGMLPSAsLGAPDGKTGKR 281
Cdd:PLN00103 230 QEVYEAQwKSKFEAAGIwyEHRLIDDMVAYALKSEGGY-VWACKNYDGDVQSDFLAQGFGSLGLMTSV-LVCPDGKTIEA 307

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516620774 282 KALYEPV--HGSAPDIAGKGIANPIAMIASFAMCLRY------SFNLVKEADDLEKAIANVLDKGIRTGD--IMADGAR- 350
Cdd:PLN00103 308 EAAHGTVtrHYRVHQKGGETSTNSIASIFAWSRGLAHrakldgNARLLDFTEKLEAACVGTVESGKMTKDlaLLIHGPKv 387

                        170       180
                 ....*....|....*....|.
gi 516620774 351 ----QVGTIEMGDAILAEFKT 367
Cdd:PLN00103 388 srdqYLNTEEFIDAVAEELKA 408
pdxA PRK00232
4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed
 289-315 9.11e-03

4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed


Pssm-ID: 234696  Cd Length: 332  Bit Score: 37.84  E-value: 9.11e-03
                         10        20
                 ....*....|....*....|....*..
gi 516620774 289 HGSAPDIAGKGIANPIAMIASFAMCLR 315
Cdd:PRK00232 299 HGTALDLAGKGIADVGSFITALNLAIR 325
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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