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Conserved domains on  [gi|516540160|ref|WP_017927785|]
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sensor histidine kinase RegB [Limimaricola hongkongensis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ActS_PrrB_HisK NF033792
ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, ...
 16-443 0e+00

ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, found in alpha-proteobacteria, shows strong sequence conservation, including the notable motif [VA]AAAAHELGTPxTI. It always acts as a partner to an ActR/PrrA/RegA family global response regulator transcription factor in a two-component sensory transduction system. Lineage-specific names and gene symbols given to this histidine kinase reflect downstream regulator changes such as entry into stationary phase, anaerobic expression of photosynthesis genes, and survival of exposure to low pH.


:

Pssm-ID: 468186 [Multi-domain]  Cd Length: 423  Bit Score: 571.77  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160  16 RRNRVRLKTQILLRWIAVAGQTGAALVAALVYGLVFPTGLVAITIGAAGIANLLAAFLMPATRRLSERESTAMLVFDVAQ 95
Cdd:NF033792   4 RSRRLRLRTLVRLRWLAVAGQTAAVLVVAFGLGFPLPLGPCLALIAASAWLNLLLTLRFPPNRRLSDREAALLLAFDILQ 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160  96 LSVLLWLTGGIDNPFALLMLAPVTIAATMLRLPGLLLVGGLALVSVTVLWLWGLPILSPQMTQLSPPALLSFGVWLALAV 175
Cdd:NF033792  84 LAALLFLTGGLQNPFALLLLAPVTISATALPLRHTLLLGALAIACATLLAFFHLPLPWYDGEPLVLPPLYLFGVWLALVI 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 176 GIIFIGLYVRRVTIEMQAMGDALAATQLALSREQKLTDLGGVVAAAAHELGTPLATITLTAAELADDLSDNPELAEDAAL 255
Cdd:NF033792 164 GIAFTAVYAWRVAEEARRLSDALAATELVLAREQHLSALDGLAAAAAHELGTPLATIALVAKELERELPDDPPLREDAEL 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 256 IRAQAIRCRDILRSMGRAG-KEDTHLRQAPLEAVVREAAEPHLARGREVVFAVGAEPengeemDAQPLIHRRPEIVHGLR 334
Cdd:NF033792 244 LRSQAERCRDILRRLTSLGeEGDAHLDRLPLSALIEEAAAPHRGFGKEIEVVVAGDP------GEEPVIRRNPEILYGLG 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 335 NLIQNAVDFSESRVEIDLSWTADSVMVKIEDDGPGFPPGLIGRIGDPFMRSRR----RPGYDGMGLGLFIAKTLLERSGA 410
Cdd:NF033792 318 NLIENAVDFARSTVTVTASWDAESVTITIEDDGPGFPPDVLSRIGEPYVTTRRgeerRPGGGGLGLGLFIAKTLLERSGA 397

                        410       420       430
                 ....*....|....*....|....*....|...
gi 516540160 411 RLSFANGGAQlrasgaaAGGAIVLLAWPRDKIE 443
Cdd:NF033792 398 TVTFANRPPP-------EGGAVVTVRWPRAALE 423
 
Name Accession Description Interval E-value
ActS_PrrB_HisK NF033792
ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, ...
 16-443 0e+00

ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, found in alpha-proteobacteria, shows strong sequence conservation, including the notable motif [VA]AAAAHELGTPxTI. It always acts as a partner to an ActR/PrrA/RegA family global response regulator transcription factor in a two-component sensory transduction system. Lineage-specific names and gene symbols given to this histidine kinase reflect downstream regulator changes such as entry into stationary phase, anaerobic expression of photosynthesis genes, and survival of exposure to low pH.


Pssm-ID: 468186 [Multi-domain]  Cd Length: 423  Bit Score: 571.77  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160  16 RRNRVRLKTQILLRWIAVAGQTGAALVAALVYGLVFPTGLVAITIGAAGIANLLAAFLMPATRRLSERESTAMLVFDVAQ 95
Cdd:NF033792   4 RSRRLRLRTLVRLRWLAVAGQTAAVLVVAFGLGFPLPLGPCLALIAASAWLNLLLTLRFPPNRRLSDREAALLLAFDILQ 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160  96 LSVLLWLTGGIDNPFALLMLAPVTIAATMLRLPGLLLVGGLALVSVTVLWLWGLPILSPQMTQLSPPALLSFGVWLALAV 175
Cdd:NF033792  84 LAALLFLTGGLQNPFALLLLAPVTISATALPLRHTLLLGALAIACATLLAFFHLPLPWYDGEPLVLPPLYLFGVWLALVI 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 176 GIIFIGLYVRRVTIEMQAMGDALAATQLALSREQKLTDLGGVVAAAAHELGTPLATITLTAAELADDLSDNPELAEDAAL 255
Cdd:NF033792 164 GIAFTAVYAWRVAEEARRLSDALAATELVLAREQHLSALDGLAAAAAHELGTPLATIALVAKELERELPDDPPLREDAEL 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 256 IRAQAIRCRDILRSMGRAG-KEDTHLRQAPLEAVVREAAEPHLARGREVVFAVGAEPengeemDAQPLIHRRPEIVHGLR 334
Cdd:NF033792 244 LRSQAERCRDILRRLTSLGeEGDAHLDRLPLSALIEEAAAPHRGFGKEIEVVVAGDP------GEEPVIRRNPEILYGLG 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 335 NLIQNAVDFSESRVEIDLSWTADSVMVKIEDDGPGFPPGLIGRIGDPFMRSRR----RPGYDGMGLGLFIAKTLLERSGA 410
Cdd:NF033792 318 NLIENAVDFARSTVTVTASWDAESVTITIEDDGPGFPPDVLSRIGEPYVTTRRgeerRPGGGGLGLGLFIAKTLLERSGA 397

                        410       420       430
                 ....*....|....*....|....*....|...
gi 516540160 411 RLSFANGGAQlrasgaaAGGAIVLLAWPRDKIE 443
Cdd:NF033792 398 TVTFANRPPP-------EGGAVVTVRWPRAALE 423
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
202-416 1.60e-34

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 128.87  E-value: 1.60e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 202 QLALSREQKLTDL-GGVVAAAAHELGTPLATITLTAAELADDLSDNPE-LAEDAALIRAQAIRCRDI---LRSMGR--AG 274
Cdd:COG2205    3 EEALEELEELERLkSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEeRRELLEIIRESAERLLRLiedLLDLSRleSG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 275 KEDTHLRQAPLEAVVREAAEP--HLARGREVVFAVGAEPENGE-EMDAQpLIHRrpeiVhgLRNLIQNAVDFS--ESRVE 349
Cdd:COG2205   83 KLSLELEPVDLAELLEEAVEElrPLAEEKGIRLELDLPPELPLvYADPE-LLEQ----V--LANLLDNAIKYSppGGTIT 155

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 516540160 350 IDLSWTADSVMVKIEDDGPGFPPGLIGRIGDPFMRSRRRPGYDGMGLGLFIAKTLLERSGARLSFAN 416
Cdd:COG2205  156 ISARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVES 222
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 329-416 2.74e-20

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 85.78  E-value: 2.74e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160   329 IVHGLRNLIQNAVDFSES--RVEIDLSWTADSVMVKIEDDGPGFPPGLIGRIGDPFMRSR-RRPGYDGMGLGLFIAKTLL 405
Cdd:smart00387   6 LRQVLSNLLDNAIKYTPEggRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDkRSRKIGGTGLGLSIVKKLV 85

                           90
                   ....*....|.
gi 516540160   406 ERSGARLSFAN 416
Cdd:smart00387  86 ELHGGEISVES 96
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 329-422 7.66e-20

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 84.19  E-value: 7.66e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 329 IVHGLRNLIQNAVDFS--ESRVEIDLSWTADSVMVKIEDDGPGFPPGLIGRIGDPFMRSRRRPGYDGMGLGLFIAKTLLE 406
Cdd:cd00075    1 LEQVLSNLLDNALKYSppGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREGGGTGLGLAIVRRIVE 80

                         90
                 ....*....|....*....
gi 516540160 407 RSGARLSFAN---GGAQLR 422
Cdd:cd00075   81 AHGGRITVESepgGGTTFT 99
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 329-416 7.92e-17

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 75.87  E-value: 7.92e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160  329 IVHGLRNLIQNAVDFS--ESRVEIDLSWtADSVMVKIEDDGPGFPPGLIGRIGDPFMRSRRRpGYDGMGLGLFIAKTLLE 406
Cdd:pfam02518   6 LRQVLSNLLDNALKHAakAGEITVTLSE-GGELTLTVEDNGIGIPPEDLPRIFEPFSTADKR-GGGGTGLGLSIVRKLVE 83

                          90
                  ....*....|
gi 516540160  407 RSGARLSFAN 416
Cdd:pfam02518  84 LLGGTITVES 93
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 164-422 7.91e-14

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 73.34  E-value: 7.91e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 164 LLSFGVWLALAVGIIFIGL-------------YVRRVT----IEMQAMG-DALAatQLALSREQKLTDLGG------VVA 219
Cdd:PRK11100 184 ILWAGALLLGIALLIGAGVvwwlnrsirrltrYADAVTegkpVPLPKLGsSELR--ELAQALESMRVKLEGkayveqYVQ 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 220 AAAHELGTPLATItLTAAELaddLSDNPElAEDAAL----IRAQAIRCRDILRSMgragkedthLRQAPLE--------- 286
Cdd:PRK11100 262 TLTHELKSPLAAI-RGAAEL---LQEDPP-PEDRARftgnILTQSARLQQLIDRL---------LELARLEqrqelevle 327

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 287 -----AVVREAAEPHLAR--GREVVFAVGAEPENGEemdAQPLIHRRpeivhGLRNLIQNAVDFS--ESRVEIDLSWTAD 357
Cdd:PRK11100 328 pvalaALLEELVEAREAQaaAKGITLRLRPDDARVL---GDPFLLRQ-----ALGNLLDNAIDFSpeGGTITLSAEVDGE 399

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 358 SVMVKIEDDGPGFPPGLIGRIGDPFMrSRRRP--GYDGMGLGLFIAKTLLERSGARLSFAN---GGAQLR 422
Cdd:PRK11100 400 QVALSVEDQGPGIPDYALPRIFERFY-SLPRPanGRKSTGLGLAFVREVARLHGGEVTLRNrpeGGVLAT 468
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
 222-413 7.18e-05

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 45.07  E-value: 7.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160  222 AHELGTPLATItLTAAELAddLSDNPELAEDAALIRAQAI---RCRDILRSM--------GRAGKEDTHLRQAPLEAVVR 290
Cdd:TIGR01386 249 AHELRTPLTNL-LGQTQVA--LSQPRTGEEYREVLESNLEeleRLSRMVSDMlflaradnGQLALERVRLDLAAELAKVA 325

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160  291 EAAEPhLARGREVVFAVgaepeNGE-EMDAQPLIHRRpeivhGLRNLIQNAVDFS--ESRVEIDLSWTADSVMVKIEDDG 367
Cdd:TIGR01386 326 EYFEP-LAEERGVRIRV-----EGEgLVRGDPQMFRR-----AISNLLSNALRHTpdGGTITVRIERRSDEVRVSVSNPG 394

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 516540160  368 PGFPPGLIGRIGDPFMR--SRRRPGYDGMGLGLFIAKTLLERSGARLS 413
Cdd:TIGR01386 395 PGIPPEHLSRLFDRFYRvdPARSNSGEGTGLGLAIVRSIMEAHGGRAS 442
 
Name Accession Description Interval E-value
ActS_PrrB_HisK NF033792
ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, ...
 16-443 0e+00

ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, found in alpha-proteobacteria, shows strong sequence conservation, including the notable motif [VA]AAAAHELGTPxTI. It always acts as a partner to an ActR/PrrA/RegA family global response regulator transcription factor in a two-component sensory transduction system. Lineage-specific names and gene symbols given to this histidine kinase reflect downstream regulator changes such as entry into stationary phase, anaerobic expression of photosynthesis genes, and survival of exposure to low pH.


Pssm-ID: 468186 [Multi-domain]  Cd Length: 423  Bit Score: 571.77  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160  16 RRNRVRLKTQILLRWIAVAGQTGAALVAALVYGLVFPTGLVAITIGAAGIANLLAAFLMPATRRLSERESTAMLVFDVAQ 95
Cdd:NF033792   4 RSRRLRLRTLVRLRWLAVAGQTAAVLVVAFGLGFPLPLGPCLALIAASAWLNLLLTLRFPPNRRLSDREAALLLAFDILQ 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160  96 LSVLLWLTGGIDNPFALLMLAPVTIAATMLRLPGLLLVGGLALVSVTVLWLWGLPILSPQMTQLSPPALLSFGVWLALAV 175
Cdd:NF033792  84 LAALLFLTGGLQNPFALLLLAPVTISATALPLRHTLLLGALAIACATLLAFFHLPLPWYDGEPLVLPPLYLFGVWLALVI 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 176 GIIFIGLYVRRVTIEMQAMGDALAATQLALSREQKLTDLGGVVAAAAHELGTPLATITLTAAELADDLSDNPELAEDAAL 255
Cdd:NF033792 164 GIAFTAVYAWRVAEEARRLSDALAATELVLAREQHLSALDGLAAAAAHELGTPLATIALVAKELERELPDDPPLREDAEL 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 256 IRAQAIRCRDILRSMGRAG-KEDTHLRQAPLEAVVREAAEPHLARGREVVFAVGAEPengeemDAQPLIHRRPEIVHGLR 334
Cdd:NF033792 244 LRSQAERCRDILRRLTSLGeEGDAHLDRLPLSALIEEAAAPHRGFGKEIEVVVAGDP------GEEPVIRRNPEILYGLG 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 335 NLIQNAVDFSESRVEIDLSWTADSVMVKIEDDGPGFPPGLIGRIGDPFMRSRR----RPGYDGMGLGLFIAKTLLERSGA 410
Cdd:NF033792 318 NLIENAVDFARSTVTVTASWDAESVTITIEDDGPGFPPDVLSRIGEPYVTTRRgeerRPGGGGLGLGLFIAKTLLERSGA 397

                        410       420       430
                 ....*....|....*....|....*....|...
gi 516540160 411 RLSFANGGAQlrasgaaAGGAIVLLAWPRDKIE 443
Cdd:NF033792 398 TVTFANRPPP-------EGGAVVTVRWPRAALE 423
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
202-416 1.60e-34

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 128.87  E-value: 1.60e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 202 QLALSREQKLTDL-GGVVAAAAHELGTPLATITLTAAELADDLSDNPE-LAEDAALIRAQAIRCRDI---LRSMGR--AG 274
Cdd:COG2205    3 EEALEELEELERLkSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEeRRELLEIIRESAERLLRLiedLLDLSRleSG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 275 KEDTHLRQAPLEAVVREAAEP--HLARGREVVFAVGAEPENGE-EMDAQpLIHRrpeiVhgLRNLIQNAVDFS--ESRVE 349
Cdd:COG2205   83 KLSLELEPVDLAELLEEAVEElrPLAEEKGIRLELDLPPELPLvYADPE-LLEQ----V--LANLLDNAIKYSppGGTIT 155

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 516540160 350 IDLSWTADSVMVKIEDDGPGFPPGLIGRIGDPFMRSRRRPGYDGMGLGLFIAKTLLERSGARLSFAN 416
Cdd:COG2205  156 ISARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVES 222
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
106-416 9.76e-33

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 126.56  E-value: 9.76e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 106 IDNPFALLMLAPVTIAATMLRLPGLLLVGGLALVSVTVLWLWGLPILSPQMTQLSPPALLSFGVWLALAVGIIFIGLYVR 185
Cdd:COG0642    2 LLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 186 RVTIEMQAMGDALAATQLALSREQKLTDLGGVVAAAAHELGTPLATITLTAAELADDLsdNPELAEDAALIRAQAIRCRD 265
Cdd:COG0642   82 LLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEEL--DEEQREYLETILRSADRLLR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 266 ILRSM-----GRAGKEDTHLRQAPLEAVVREAAEP--HLARGREVVFAVGAEPengeemDAQPLIHRRPEIVHGLRNLIQ 338
Cdd:COG0642  160 LINDLldlsrLEAGKLELEPEPVDLAELLEEVVELfrPLAEEKGIELELDLPD------DLPTVRGDPDRLRQVLLNLLS 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 339 NAVDFSE--SRVEIDLSWTADSVMVKIEDDGPGFPPGLIGRIGDPFMRSRRRPGYDGMGLGLFIAKTLLERSGARLSFAN 416
Cdd:COG0642  234 NAIKYTPegGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGGGTGLGLAIVKRIVELHGGTIEVES 313
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 78-416 8.60e-29

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 116.44  E-value: 8.60e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160  78 RRLSERESTAMLVFDVAQLSVLLWLTGGIDNPFALLMLAPVTIAATMLRLPGLLLVGGLALVSVTVLWLWGLPILSPQMT 157
Cdd:COG4191    7 LLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 158 QLSPPALLSFGVWLALAVGIIFIGLYVRRVTIEMQAMgDALAATQLALSREQKLTDLGGVVAAAAHELGTPLATITLTAA 237
Cdd:COG4191   87 LLLLEALLLLLLAALDAEENAELEELERDITELERAE-EELRELQEQLVQSEKLAALGELAAGIAHEINNPLAAILGNAE 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 238 ELADDLSDNP---ELAEDAALIRAQAIRCRDILRSMGR-AGKEDTHLRQAPLEAVVREA---AEPHLARGR-EVVFAVGA 309
Cdd:COG4191  166 LLRRRLEDEPdpeELREALERILEGAERAAEIVRSLRAfSRRDEEEREPVDLNELIDEAlelLRPRLKARGiEVELDLPP 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 310 EPengeemdaqPLIH-RRPEIVHGLRNLIQNAVD----FSESRVEIDLSWTADSVMVKIEDDGPGFPPGLIGRIGDPFMr 384
Cdd:COG4191  246 DL---------PPVLgDPGQLEQVLLNLLINAIDameeGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFF- 315

                        330       340       350
                 ....*....|....*....|....*....|..
gi 516540160 385 SRRRPGyDGMGLGLFIAKTLLERSGARLSFAN 416
Cdd:COG4191  316 TTKPVG-KGTGLGLSISYGIVEKHGGRIEVES 346
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
55-416 2.22e-26

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 110.03  E-value: 2.22e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160  55 LVAITIGAAGIANLLAAFLMPATRRLSERESTAMLVFDVAQLSVLLWLTGGIDNPFALLMLAPVTIAATMLRLPGLLLVG 134
Cdd:COG5002    5 LLLLLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 135 GLALVSVTVLWLWGLPILSPQMTQLSPPALLSFGVWLALAVGIIFIGLYVRRVTIEMQAMGDALAATQLALSREQKL--- 211
Cdd:COG5002   85 LLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLeqm 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 212 -TDLggvVAAAAHELGTPLATITLTAAELADDLSDNPELAEDA-ALIRAQAIRCR----DILR-SMGRAGKEDTHLRQAP 284
Cdd:COG5002  165 rREF---VANVSHELRTPLTSIRGYLELLLDGAADDPEERREYlEIILEEAERLSrlvnDLLDlSRLESGELKLEKEPVD 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 285 LEAVVREAAE--PHLARGREVVFAVGAEPENGE-EMDAQplihrrpEIVHGLRNLIQNAVDFSE--SRVEIDLSWTADSV 359
Cdd:COG5002  242 LAELLEEVVEelRPLAEEKGIELELDLPEDPLLvLGDPD-------RLEQVLTNLLDNAIKYTPegGTITVSLREEDDQV 314

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 360 MVKIEDDGPGFPPGLIGRIGDPFMR---SRRRpGYDGMGLGLFIAKTLLERSGARLSFAN 416
Cdd:COG5002  315 RISVRDTGIGIPEEDLPRIFERFYRvdkSRSR-ETGGTGLGLAIVKHIVEAHGGRIWVES 373
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 204-420 2.34e-23

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 101.58  E-value: 2.34e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 204 ALSREQKLTDLGGVVAAAAHELGTPLATITLTAAELADDLS-----DNPELAEDAALIRAQAIRCRDILRSMGR-AGKED 277
Cdd:COG5000  191 ELLRAERLAAWGELARRIAHEIKNPLTPIQLSAERLRRKLAdkleeDREDLERALDTIIRQVDRLKRIVDEFLDfARLPE 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 278 THLRQAPLEAVVREAAE--PHLARGREVVFAVGAEPENGE-EMDAQPLihrrpEIVhgLRNLIQNAVDFSESRVEIDLSW 354
Cdd:COG5000  271 PQLEPVDLNELLREVLAlyEPALKEKDIRLELDLDPDLPEvLADRDQL-----EQV--LINLLKNAIEAIEEGGEIEVST 343

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 516540160 355 TA--DSVMVKIEDDGPGFPPGLIGRIGDPFMRSRRrpgyDGMGLGLFIAKTLLERSGARLSFAN---GGAQ 420
Cdd:COG5000  344 RRedGRVRIEVSDNGPGIPEEVLERIFEPFFTTKP----KGTGLGLAIVKKIVEEHGGTIELESrpgGGTT 410
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 329-416 2.74e-20

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 85.78  E-value: 2.74e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160   329 IVHGLRNLIQNAVDFSES--RVEIDLSWTADSVMVKIEDDGPGFPPGLIGRIGDPFMRSR-RRPGYDGMGLGLFIAKTLL 405
Cdd:smart00387   6 LRQVLSNLLDNAIKYTPEggRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDkRSRKIGGTGLGLSIVKKLV 85

                           90
                   ....*....|.
gi 516540160   406 ERSGARLSFAN 416
Cdd:smart00387  86 ELHGGEISVES 96
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 329-422 7.66e-20

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 84.19  E-value: 7.66e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 329 IVHGLRNLIQNAVDFS--ESRVEIDLSWTADSVMVKIEDDGPGFPPGLIGRIGDPFMRSRRRPGYDGMGLGLFIAKTLLE 406
Cdd:cd00075    1 LEQVLSNLLDNALKYSppGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREGGGTGLGLAIVRRIVE 80

                         90
                 ....*....|....*....
gi 516540160 407 RSGARLSFAN---GGAQLR 422
Cdd:cd00075   81 AHGGRITVESepgGGTTFT 99
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
185-414 2.20e-18

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 86.05  E-value: 2.20e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 185 RRVTIEMQAMGDALAATQlALSREQKLTDLGGVVAAAAHELGTPLATITLtAAELADDLSDNPELAEDAALIRAQAIRCR 264
Cdd:COG3852  107 GGVLLVLRDITERKRLER-ELRRAEKLAAVGELAAGLAHEIRNPLTGIRG-AAQLLERELPDDELREYTQLIIEEADRLN 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 265 DILRSM-GRAGKEDTHLRQAPLEAVVREA---AEPHLARGREVVfavgaepengEEMDAQ--PLIHRRPEIVHGLRNLIQ 338
Cdd:COG3852  185 NLVDRLlSFSRPRPPEREPVNLHEVLERVlelLRAEAPKNIRIV----------RDYDPSlpEVLGDPDQLIQVLLNLVR 254

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 339 NAVD------------FSESRVEIDLSWTADSVMVKIEDDGPGFPPGLIGRIGDPFMRSRRrpgyDGMGLGLFIAKTLLE 406
Cdd:COG3852  255 NAAEampeggtitirtRVERQVTLGGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFFTTKE----KGTGLGLAIVQKIVE 330


                 ....*...
gi 516540160 407 RSGARLSF 414
Cdd:COG3852  331 QHGGTIEV 338
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 7-413 3.94e-18

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 86.76  E-value: 3.94e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160   7 ELAMLRDFGRRNRVRLKTQILLRWIAVAGQTGAALVAALVYGLVFPTGLVAITIGAAGIANLLAAFLMPATRRLSEREST 86
Cdd:COG4251   64 LLLLLLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALL 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160  87 AMLVFDVAQLSVLLWLTGGIDNPFALLMLAPVTIAATMLRLPGLLLVGGLALVSVTVLWLWGLPILSPQMTQLSPPALLS 166
Cdd:COG4251  144 RLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGG 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 167 FGVWLALAVGIIFIGLYVRRVTIEMQAMGDALAATQLALSREQKLT-----------DLGGVVAAAAHELGTPLATITLT 235
Cdd:COG4251  224 GLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEertaelersneELEQFAYVASHDLREPLRKISGF 303

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 236 AAELADDLSD--NPELAEDAALIRAQAIRCRDI---LRSMGRAGKEDTHLRQAPLEAVVREAAE--PHLARGREVVFAVG 308
Cdd:COG4251  304 SQLLEEDYGDklDEEGREYLERIRDAAERMQALiddLLAYSRVGRQELEFEPVDLNELLEEVLEdlEPRIEERGAEIEVG 383

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 309 AEPE-NGeemDAQPLihrrpEIVhgLRNLIQNAVDFSES----RVEIDLSWTADSVMVKIEDDGPGFPPGLIGRIGDPFM 383
Cdd:COG4251  384 PLPTvRG---DPTLL-----RQV--FQNLISNAIKYSRPgeppRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQ 453

                        410       420       430
                 ....*....|....*....|....*....|
gi 516540160 384 RSRRRPGYDGMGLGLFIAKTLLERSGARLS 413
Cdd:COG4251  454 RLHSRDEYEGTGIGLAIVKKIVERHGGRIW 483
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 329-416 7.92e-17

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 75.87  E-value: 7.92e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160  329 IVHGLRNLIQNAVDFS--ESRVEIDLSWtADSVMVKIEDDGPGFPPGLIGRIGDPFMRSRRRpGYDGMGLGLFIAKTLLE 406
Cdd:pfam02518   6 LRQVLSNLLDNALKHAakAGEITVTLSE-GGELTLTVEDNGIGIPPEDLPRIFEPFSTADKR-GGGGTGLGLSIVRKLVE 83

                          90
                  ....*....|
gi 516540160  407 RSGARLSFAN 416
Cdd:pfam02518  84 LLGGTITVES 93
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 164-422 7.91e-14

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 73.34  E-value: 7.91e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 164 LLSFGVWLALAVGIIFIGL-------------YVRRVT----IEMQAMG-DALAatQLALSREQKLTDLGG------VVA 219
Cdd:PRK11100 184 ILWAGALLLGIALLIGAGVvwwlnrsirrltrYADAVTegkpVPLPKLGsSELR--ELAQALESMRVKLEGkayveqYVQ 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 220 AAAHELGTPLATItLTAAELaddLSDNPElAEDAAL----IRAQAIRCRDILRSMgragkedthLRQAPLE--------- 286
Cdd:PRK11100 262 TLTHELKSPLAAI-RGAAEL---LQEDPP-PEDRARftgnILTQSARLQQLIDRL---------LELARLEqrqelevle 327

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 287 -----AVVREAAEPHLAR--GREVVFAVGAEPENGEemdAQPLIHRRpeivhGLRNLIQNAVDFS--ESRVEIDLSWTAD 357
Cdd:PRK11100 328 pvalaALLEELVEAREAQaaAKGITLRLRPDDARVL---GDPFLLRQ-----ALGNLLDNAIDFSpeGGTITLSAEVDGE 399

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 358 SVMVKIEDDGPGFPPGLIGRIGDPFMrSRRRP--GYDGMGLGLFIAKTLLERSGARLSFAN---GGAQLR 422
Cdd:PRK11100 400 QVALSVEDQGPGIPDYALPRIFERFY-SLPRPanGRKSTGLGLAFVREVARLHGGEVTLRNrpeGGVLAT 468
PRK10337 PRK10337
sensor protein QseC; Provisional
 182-416 2.08e-13

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 71.99  E-value: 2.08e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 182 LYVRRVTIEMQAMGDAL----AATQLALSREQKLTdlggvvAAAAHELGTPLATITLTAaELADdLSDNPELAEDAALIR 257
Cdd:PRK10337 207 LNATGVPSEVRPLVEALnqlfARTHAMMVRERRFT------SDAAHELRSPLAALKVQT-EVAQ-LSDDDPQARKKALLQ 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 258 A-----QAIRCRDILRSMGRAGKEDT--HLRQAPLEAVVREAAEPHLARgrevvfAVGAEPENGEEMDAQPLIHRRPEIV 330
Cdd:PRK10337 279 LhagidRATRLVDQLLTLSRLDSLDNlqDVAEIPLEDLLQSAVMDIYHT------AQQAGIDVRLTLNAHPVIRTGQPLL 352

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 331 HGL--RNLIQNAVDFSESRVEIDLSWTADSVmvKIEDDGPGFPPGLIGRIGDPFMRSrrrPGYD--GMGLGLFIAKTLLE 406
Cdd:PRK10337 353 LSLlvRNLLDNAIRYSPQGSVVDVTLNARNF--TVRDNGPGVTPEALARIGERFYRP---PGQEatGSGLGLSIVRRIAK 427

                        250
                 ....*....|
gi 516540160 407 RSGARLSFAN 416
Cdd:PRK10337 428 LHGMNVSFGN 437
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 324-417 1.13e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 64.35  E-value: 1.13e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 324 HRRPEIVHG--------LRNLIQNAVDFS--ESRVEIDLSWTADSVMvKIEDDGPGFPPGLIGRIGDPFMRSRRRpGYDG 393
Cdd:cd16940    1 SAADIQVQGdalllfllLRNLVDNAVRYSpqGSRVEIKLSADDGAVI-RVEDNGPGIDEEELEALFERFYRSDGQ-NYGG 78

                         90       100
                 ....*....|....*....|....
gi 516540160 394 MGLGLFIAKTLLERSGARLSFANG 417
Cdd:cd16940   79 SGLGLSIVKRIVELHGGQIFLGNA 102
PRK10490 PRK10490
sensor protein KdpD; Provisional
 199-422 1.81e-12

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 69.68  E-value: 1.81e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 199 AATQLALSREQKLTDLggvVAAAAHELGTPLaTITLTAAE-LADDL-SDNPELAEDAALIRAQ---AIRCRDILRSMGRA 273
Cdd:PRK10490 652 EQARLASEREQLRNAL---LAALSHDLRTPL-TVLFGQAEiLTLDLaSEGSPHARQASEIRQQvlnTTRLVNNLLDMARI 727

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 274 GKEDTHLRQA--PLEAVVREAA---EPHLArGREVVFAVGAEpengeemdaQPLIH-RRPEIVHGLRNLIQNAVDFSESR 347
Cdd:PRK10490 728 QSGGFNLRKEwlTLEEVVGSALqmlEPGLS-GHPINLSLPEP---------LTLIHvDGPLFERVLINLLENAVKYAGAQ 797

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 348 VE--IDLSWTADSVMVKIEDDGPGFPPGLIGRIGDPFMRSRRRPGYDGMGLGLFIAKTLLERSGARLSFAN---GGAQLR 422
Cdd:PRK10490 798 AEigIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESAIPGVGLGLAICRAIVEVHGGTIWAENrpeGGACFR 877
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 333-422 1.89e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 63.24  E-value: 1.89e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 333 LRNLIQNAVD----FSESRVEIDLSWTADSVMVKIEDDGPGFPPGLIGRIGDPFMRSrrRPGYDGMGLGLFIAKTLLERS 408
Cdd:cd16976    5 LMNLLQNALDamgkVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTT--KPVGKGTGLGLSISYGIVEEH 82

                         90
                 ....*....|....*..
gi 516540160 409 GARLSFAN---GGAQLR 422
Cdd:cd16976   83 GGRLSVANeegAGARFT 99
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 333-422 8.04e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 61.57  E-value: 8.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 333 LRNLIQNAVDFSESRVEIDLSWTADSVMVKIEDDGPGFPPGLIGRIGDPFMR---SRRRPGyDGMGLGLFIAKTLLERSG 409
Cdd:cd16949    5 LENVLRNALRYSPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRvdsARDRES-GGTGLGLAIAERAIEQHG 83

                         90
                 ....*....|....*.
gi 516540160 410 ARLSFAN---GGAQLR 422
Cdd:cd16949   84 GKIKASNrkpGGLRVR 99
PRK10604 PRK10604
sensor protein RstB; Provisional
 186-400 5.07e-11

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 64.24  E-value: 5.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 186 RVTIEMQAMGDALAAtqLALSREQkLTDlggvvaAAAHELGTPLATITLTAAeladdLSDNPELAEDAALIR--AQAIRC 263
Cdd:PRK10604 193 RLGVAFNQMADNINA--LIASKKQ-LID------GIAHELRTPLVRLRYRLE-----MSDNLSAAESQALNRdiGQLEAL 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 264 RDILRSMGRAGKEDTHLRQAPLEAvvreaaePHLARGREVVFAVGaEPENGEEMD----AQPLIHRRPEIVHGLRNLIQN 339
Cdd:PRK10604 259 IEELLTYARLDRPQNELHLSEPDL-------PAWLSTHLADIQAV-TPEKTVRLDtphqGDYGALDMRLMERVLDNLLNN 330

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 516540160 340 AVDFSESRVEIDLSWTADSVMVKIEDDGPGFPPGLIGRIGDPFMR---SR-RRPGydGMGLGLFI 400
Cdd:PRK10604 331 ALRYAHSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRldpSRdRATG--GCGLGLAI 393
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 333-439 5.19e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 59.37  E-value: 5.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 333 LRNLIQNAVDFSESRVEIDLSWTADSVMVKIEDDGPGFPPGLIGRIGDPFMR---SRRRPGyDGMGLGLFIAKTLLERSG 409
Cdd:cd16939    5 LDNLLRNALRYAHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRldpSRDRAT-GGFGLGLAIVHRVALWHG 83

                         90       100       110
                 ....*....|....*....|....*....|...
gi 516540160 410 ARLSFAN---GGAQLRasgaaaggaivlLAWPR 439
Cdd:cd16939   84 GHVECDDselGGACFR------------LTWPR 104
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 326-422 1.16e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 58.32  E-value: 1.16e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 326 RPEIVHGLRNLIQNAVDFSESR------VEIDLSWTADS-VMVKIEDDGPGFPPGLIGRIGDPFMRSRRRpgydGMGLGL 398
Cdd:cd16944    2 TTQISQVLTNILKNAAEAIEGRpsdvgeVRIRVEADQDGrIVLIVCDNGKGFPREMRHRATEPYVTTRPK----GTGLGL 77

                         90       100
                 ....*....|....*....|....*..
gi 516540160 399 FIAKTLLERSGARLSFAN---GGAQLR 422
Cdd:cd16944   78 AIVKKIMEEHGGRISLSNreaGGACIR 104
envZ PRK09467
osmolarity sensor protein; Provisional
 219-416 2.33e-10

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 62.24  E-value: 2.33e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 219 AAAAHELGTPLATITLtAAEL---ADD-LSD--NPELAEDAALIrAQAIrcrDILRSmgraGKEDThLRQAPLEAVVREA 292
Cdd:PRK09467 234 AGVSHDLRTPLTRIRL-ATEMmseEDGyLAEsiNKDIEECNAII-EQFI---DYLRT----GQEMP-MEMADLNALLGEV 303

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 293 AEPHLARGREVVFAVGAEPENgeeMDAQPLIHRRpeivhGLRNLIQNAVDFSESRVEIDLSWTADSVMVKIEDDGPGFPP 372
Cdd:PRK09467 304 IAAESGYEREIETALQPGPIE---VPMNPIAIKR-----ALANLVVNAARYGNGWIKVSSGTEGKRAWFQVEDDGPGIPP 375

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 516540160 373 GLIGRIGDPFMRSRRRPGYDGMGLGLFIAKTLLERSGARLSFAN 416
Cdd:PRK09467 376 EQLKHLFQPFTRGDSARGSSGTGLGLAIVKRIVDQHNGKVELGN 419
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 333-422 6.83e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 56.87  E-value: 6.83e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 333 LRNLIQNAVDFSESRVEIDLSWTADSVMVKIEDDGPGFPPGLIGRIGDPFMR-SRRRPGYdgmGLGLFIAKTLLERSGAR 411
Cdd:cd16954   42 LGNLLDNACKWCLEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRlDEQRPGQ---GLGLAIAKEIVEQYGGE 118

                         90
                 ....*....|....
gi 516540160 412 LSFAN---GGAQLR 422
Cdd:cd16954  119 LSLSDsplGGARFE 132
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
192-400 1.17e-09

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 59.60  E-value: 1.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 192 QAMGDALAATQLALSREQKLTdlggvvAAAAHELGTPLATITLtaaeladdlsdNPELAEDAALIRAQAIRCR------- 264
Cdd:PRK10755 121 SALNQLVSRLTSTLDQERLFT------ADVAHELRTPLAGIRL-----------HLELLEKQHHIDVAPLIARldqmmht 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 265 -DILRSMGRAGKEDTHLRQAPLEAVvreaaephlargREVVFAVGAEPENGEEMDAQPLIHRRPE---IVHG-------- 332
Cdd:PRK10755 184 vEQLLQLARAGQSFSSGHYQTVKLL------------EDVILPSQDELSEMLEQRQQTLLLPESAadiTVQGdatllrll 251

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 333 LRNLIQNAVDFS--ESRVEIDLSWTADSVMVKIEDDGPGFPPGLIGRIGDPFMRSRRRpgYDGMGLGLFI 400
Cdd:PRK10755 252 LRNLVENAHRYSpeGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRMDSR--YGGIGLGLSI 319
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 333-422 1.43e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 55.15  E-value: 1.43e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 333 LRNLIQNAVDFSESRVEIDLSWTADSVMVKIEDDGPGFPPGLIGRIGDPFMRSRRRPGYDGMGLGLFIAKTLLERSGARL 412
Cdd:cd16950    5 LSNLVDNALRYGGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGTSGTGLGLAIVQRISDAHGGSL 84

                         90
                 ....*....|...
gi 516540160 413 SFAN---GGAQLR 422
Cdd:cd16950   85 TLANragGGLCAR 97
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 326-409 1.66e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 55.12  E-value: 1.66e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 326 RPEIVHGLRNLIQNAVDFSESRVEIDL-SW-TADSVMVKIEDDGPGFPPGLIGRIGDPFMRSrrRPGYDGMGLGLFIAKT 403
Cdd:cd16943    1 PSQLNQVLLNLLVNAAQAMEGRGRITIrTWaHVDQVLIEVEDTGSGIDPEILGRIFDPFFTT--KPVGEGTGLGLSLSYR 78


                 ....*.
gi 516540160 404 LLERSG 409
Cdd:cd16943   79 IIQKHG 84
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 333-414 1.88e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 54.81  E-value: 1.88e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 333 LRNLIQNAVDFSES-----RVE-IDLSWTADSVMVKIEDDGPGFPPGLIGRIGDPFMR-----SRRrpgYDGMGLGLFIA 401
Cdd:cd16922    5 LLNLLGNAIKFTEEgevtlRVSlEEEEEDGVQLRFSVEDTGIGIPEEQQARLFEPFSQadsstTRK---YGGTGLGLAIS 81

                         90
                 ....*....|...
gi 516540160 402 KTLLERSGARLSF 414
Cdd:cd16922   82 KKLVELMGGDISV 94
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 335-414 2.01e-09

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 59.36  E-value: 2.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 335 NLIQNAVDFSESRVEIDLSWTA--DSVMVKIEDDGPGFPPGLIGRIGDPFMRSRRRpgydGMGLGLFIAKTLLERSGARL 412
Cdd:COG5805  402 NLIKNAIEAMPNGGTITIHTEEedNSVIIRVIDEGIGIPEERLKKLGEPFFTTKEK----GTGLGLMVSYKIIENHNGTI 477


                 ..
gi 516540160 413 SF 414
Cdd:COG5805  478 DI 479
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 333-422 2.76e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 54.32  E-value: 2.76e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 333 LRNLIQNAV----DFSESRVEIDLSWT---ADSVMVKIEDDGPGFPPGLIGRIGDPFMRSRRrpgyDGMGLGLFIAKTLL 405
Cdd:cd16920    5 LINLVRNGIeamsEGGCERRELTIRTSpadDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKS----EGLGMGLSICRSII 80

                         90       100
                 ....*....|....*....|
gi 516540160 406 ERSGARLSF---ANGGAQLR 422
Cdd:cd16920   81 EAHGGRLSVespAGGGATFQ 100
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 333-409 6.15e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 53.73  E-value: 6.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 333 LRNLIQNAVDFS---ESRVEIDLSWTADSVMVKIEDDGPGFPPGLIGRIGDPFMRSRRRPGYDGM--GLGLFIAKTLLER 407
Cdd:cd16953    5 LRNLIGNAISFSppdTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQhsGLGLSISRQIIEA 84


                 ..
gi 516540160 408 SG 409
Cdd:cd16953   85 HG 86
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 333-418 6.59e-09

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 57.55  E-value: 6.59e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 333 LRNLIQNAVD------FSESRVEIDLSWTADSVMVKIEDDGPGFPPGLIGRIgdpFmrsrrRPGY-----DGMGLGLFIA 401
Cdd:COG3290  286 LGNLLDNAIEaveklpEEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKI---F-----ERGFstklgEGRGLGLALV 357

                         90
                 ....*....|....*..
gi 516540160 402 KTLLERSGARLSFANGG 418
Cdd:COG3290  358 KQIVEKYGGTIEVESEE 374
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 335-416 8.08e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 53.36  E-value: 8.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 335 NLIQNAVDFSESRVEIDLSWTAD--SVMVKIEDDGPGFPPGLIGRIGDPFMR--SRRRPGYDGMGLGLFIAKTLLERSGA 410
Cdd:cd16952    7 NLVSNAVKYTPPSDTITVRWSQEesGARLSVEDTGPGIPPEHIPRLTERFYRvdIERCRNTGGTGLGLAIVKHVMSRHDA 86


                 ....*.
gi 516540160 411 RLSFAN 416
Cdd:cd16952   87 RLLIAS 92
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 319-414 2.88e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 48.94  E-value: 2.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 319 AQPLIHRRPEIVhgLRNLIQNAVDFSESRVEIDLSwtadsvmVKIEDDGPGFPPGLIGRIGDPFMRSRRrpgyDGMGLGL 398
Cdd:cd16918   13 AQALAGSGGEII--LRTRTQRQVTLGHPRHRLALR-------VSVIDNGPGIPPDLQDTIFYPMVSGRE----NGTGLGL 79

                         90
                 ....*....|....*.
gi 516540160 399 FIAKTLLERSGARLSF 414
Cdd:cd16918   80 AIAQNIVSQHGGVIEC 95
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 333-415 2.98e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 48.61  E-value: 2.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 333 LRNLIQNAVDFSES--RVEIDLSWTADSVMVKIEDDGPGFPPGLIGRIGDPFMR---SRRRPGyDGMGLGLFIAKTLLER 407
Cdd:cd16946    9 FVNLLENSLRYTDTggKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRvesSRNRAS-GGSGLGLAICHNIALA 87


                 ....*...
gi 516540160 408 SGARLSFA 415
Cdd:cd16946   88 HGGTISAE 95
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 333-422 3.08e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 48.61  E-value: 3.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 333 LRNLIQNAVDFSESRVEIDLSWTADSVMVK--IEDDGPGFPPGLIGRIGDPFMR---SRRRPGYDGMGLglFIAKTLLER 407
Cdd:cd16975    9 LINIISNACQYAPEGGTVSISIYDEEEYLYfeIWDNGHGFSEQDLKKALELFYRddtSRRSGGHYGMGL--YIAKNLVEK 86

                         90
                 ....*....|....*...
gi 516540160 408 SGARLSFAN---GGAQLR 422
Cdd:cd16975   87 HGGSLIIENsqkGGAEVT 104
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
164-379 6.04e-07

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 50.39  E-value: 6.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 164 LLSFGVWLALAVGIIFIGLYVRRVTIEMQAMGDALAATQLALSREQKLTDLggvvaaaAHEL----GTPLATITLTAAEL 239
Cdd:COG4585    7 LGALALLVGALLGLLLALVLLRARRAERAAELERELAARAEEAREEERRRI-------ARELhdgvGQSLSAIKLQLEAA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 240 ADDLSDNPELAEDA-----ALIRAQAIRCRDILRSMGRAGKEDTHLRQApLEAVVREAAEPHlarGREVVFAVGAEPENg 314
Cdd:COG4585   80 RRLLDADPEAAREEleeirELAREALAELRRLVRGLRPPALDDLGLAAA-LEELAERLLRAA---GIRVELDVDGDPDR- 154

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 516540160 315 EEMDAQPLIHRrpeIVhglRNLIQNAVDFSE-SRVEIDLSWTADSVMVKIEDDGPGFPPGLIGRIG 379
Cdd:COG4585  155 LPPEVELALYR---IV---QEALTNALKHAGaTRVTVTLEVDDGELTLTVRDDGVGFDPEAAPGGG 214
HisKA cd00082
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...
 214-270 8.84e-07

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.


Pssm-ID: 119399 [Multi-domain]  Cd Length: 65  Bit Score: 46.05  E-value: 8.84e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 516540160 214 LGGVVAAAAHELGTPLATITLTAAELADDLSDNPELAEDAALIRAQAIRCRDILRSM 270
Cdd:cd00082    4 KGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDL 60
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 198-419 1.10e-06

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 50.84  E-value: 1.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 198 LAATQLALSREQKLTDLGGVVAAAAHELGTPL--ATITLTAAELADDLSDNPELAEDAALIRAQAIRCRDI---LRSMGR 272
Cdd:COG4192  417 LRQTQDELIQAAKMAVVGQTMTSLAHELNQPLnaMSMYLFSAKKALEQENYAQLPTSLDKIEGLIERMDKIiksLRQFSR 496

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 273 agKEDTHLRQAPLEAVVREAAEPHLARGREVVFAVGAEPENGEEMDAQPLihrrpEIVhgLRNLIQNAVDFSESRVEIDL 352
Cdd:COG4192  497 --KSDTPLQPVDLRQVIEQAWELVESRAKPQQITLHIPDDLMVQGDQVLL-----EQV--LVNLLVNALDAVATQPQISV 567

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 516540160 353 SW--TADSVMVKIEDDGPGFPpgLIGRIGDPFMRSRRRpgydGMGLGLFIAKTLLERSGARLSFA---NGGA 419
Cdd:COG4192  568 DLlsNAENLRVAISDNGNGWP--LVDKLFTPFTTTKEV----GLGLGLSICRSIMQQFGGDLYLAstlERGA 633
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 335-420 1.29e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 46.90  E-value: 1.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 335 NLIQNAVD------FSESRVEIDLSWTADSVMVKIEDDGPGFPPGLIGRIgdpFMRSRRRPGYDGMGLGLFIAKTLLERS 408
Cdd:cd16915    7 NLIDNALDalaatgAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKV---FERGVSTKGQGERGIGLALVRQSVERL 83

                         90
                 ....*....|....*
gi 516540160 409 GARLSFAN---GGAQ 420
Cdd:cd16915   84 GGSITVESepgGGTT 98
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 333-413 2.61e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 45.84  E-value: 2.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 333 LRNLIQNAVDFS--ESRVEIDLSWTADSVMVKIEDDGPGFPPGLIGRIGDPFMRSRRRPGYDGMGLGLFIAKTLLERSGA 410
Cdd:cd16923    5 FSNLLSNAIKYSpeNTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNTEGAGLGLSIAKAIIELHGG 84


                 ...
gi 516540160 411 RLS 413
Cdd:cd16923   85 SAS 87
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
333-402 2.93e-06

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 49.58  E-value: 2.93e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 516540160 333 LRNLIQNAVDFSESRVEIDLS-W--TADSVMVKIEDDGPGFPPGLIGRIGDPFMRSRRRpgydGMGLGLFIAK 402
Cdd:PRK11360 505 LLNILINAVQAISARGKIRIRtWqySDGQVAVSIEDNGCGIDPELLKKIFDPFFTTKAK----GTGLGLALSQ 573
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 329-419 3.27e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 45.78  E-value: 3.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 329 IVHGLRNLIQNAVDFSESR----VEIDLSWTADSVMVKIEDDGPGFPPGLIGRIGDPFMRSRRRPGYDGMGLGLFIAKTL 404
Cdd:cd16921    1 LGQVLTNLLGNAIKFRRPRrpprIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSREEYEGTGVGLAIVRKI 80

                         90
                 ....*....|....*...
gi 516540160 405 LERSGARL---SFANGGA 419
Cdd:cd16921   81 IERHGGRIwleSEPGEGT 98
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
 218-270 3.69e-06

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 44.12  E-value: 3.69e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 516540160  218 VAAAAHELGTPLATItLTAAELADDLSDNPELAEDAALIRAQAIRCRDILRSM 270
Cdd:pfam00512   6 LANLSHELRTPLTAI-RGYLELLRDEKLDEEQREYLETILRSAERLLRLINDL 57
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
164-420 6.65e-06

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 48.24  E-value: 6.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 164 LLSFGVWLALAVGIIFIGLYVRRVTIEMQAMGDALAatqlalsREQKLTDLGGVVAAAAHELGTPLATITLTAAELADDL 243
Cdd:PRK10364 194 LIILFALATVLLASLLAFFWYRRYLRSRQLLQDEMK-------RKEKLVALGHLAAGVAHEIRNPLSSIKGLAKYFAERA 266

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 244 SDNPELAEDAALIRAQAIRCRDILRSMGRAGKEdTHLRQAP--LEAVVREAAE--PHLARGREVVFAVGAEPEngeemda 319
Cdd:PRK10364 267 PAGGEAHQLAQVMAKEADRLNRVVSELLELVKP-THLALQAvdLNDLINHSLQlvSQDANSREIQLRFTANDT------- 338

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 320 QPLIHRRPE-IVHGLRNLIQNAVDF--SESRVEIDLSWTADSVMVKIEDDGPGFPPGLIGRIGDPFMRSRRrpgyDGMGL 396
Cdd:PRK10364 339 LPEIQADPDrLTQVLLNLYLNAIQAigQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKA----EGTGL 414

                        250       260
                 ....*....|....*....|....
gi 516540160 397 GLFIAKTLLERSGARLSFANGGAQ 420
Cdd:PRK10364 415 GLAVVHNIVEQHGGTIQVASQEGK 438
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 335-414 8.14e-06

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 48.05  E-value: 8.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 335 NLIQNAVDFSESRVEIDLSWTA---DSVMVKIEDDGPGFPPGLIGRIGDPFMRSRRRpgydGMGLGLFIAKTLLERSGAR 411
Cdd:COG5809  386 NLLKNAIEAMPEGGNITIETKAeddDKVVISVTDEGCGIPEERLKKLGEPFYTTKEK----GTGLGLMVSYKIIEEHGGK 461


                 ...
gi 516540160 412 LSF 414
Cdd:COG5809  462 ITV 464
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
335-421 1.32e-05

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 47.32  E-value: 1.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 335 NLIQNAVDFSESRVEIDLSWTADSVMVKIEDDGPGFPPG---LIgrigdpFMRSRR----RPgydGMGLGLFIAKTLLER 407
Cdd:PRK10815 385 NVLDNACKYCLEFVEISARQTDEHLHIVVEDDGPGIPESkreLI------FDRGQRadtlRP---GQGLGLSVAREITEQ 455

                         90
                 ....*....|....*..
gi 516540160 408 SGARLSFAN---GGAQL 421
Cdd:PRK10815 456 YEGKISAGDsplGGARM 472
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
316-412 1.78e-05

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 46.93  E-value: 1.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 316 EMDAQPLIHRRPEIV----HGLR-------------NLIQNAVDFSESRVEIDLSW--TADSVMVKIEDDGPGFPPGLIG 376
Cdd:PRK11006 288 EREAQTLSQGKHTITfevdNSLKvfgnedqlrsaisNLVYNAVNHTPEGTHITVRWqrVPQGAEFSVEDNGPGIAPEHIP 367

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 516540160 377 RIGDPFMR---SR-RRPGydGMGLGLFIAKTLLERSGARL 412
Cdd:PRK11006 368 RLTERFYRvdkARsRQTG--GSGLGLAIVKHALSHHDSRL 405
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
333-403 2.90e-05

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 46.08  E-value: 2.90e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 516540160 333 LRNLIQNAVDFSESRVEIDLSWTADSVMVKIEDDGPGFPPGLIGRIGDPFMR---SR-RRPGydGMGLGLFIAKT 403
Cdd:PRK09470 358 LENIVRNALRYSHTKIEVAFSVDKDGLTITVDDDGPGVPEEEREQIFRPFYRvdeARdRESG--GTGLGLAIVEN 430
HisKA smart00388
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...
 218-270 4.21e-05

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.


Pssm-ID: 214644 [Multi-domain]  Cd Length: 66  Bit Score: 41.40  E-value: 4.21e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 516540160   218 VAAAAHELGTPLATItLTAAELADDLSDNPELAEDAALIRAQAIRCRDILRSM 270
Cdd:smart00388   6 LANLSHELRTPLTAI-RGYLELLLDTELSEEQREYLETILREAERLLRLINDL 57
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
336-404 6.46e-05

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 42.59  E-value: 6.46e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 516540160 336 LIQNAV-----DFSESRVEIDLSWTADSVMVKIEDDGPGFPPgliGRIGDPFMRSRrrpgydGMGLGLFIAKTL 404
Cdd:COG2172   42 AVTNAVrhaygGDPDGPVEVELELDPDGLEIEVRDEGPGFDP---EDLPDPYSTLA------EGGRGLFLIRRL 106
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
 222-413 7.18e-05

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 45.07  E-value: 7.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160  222 AHELGTPLATItLTAAELAddLSDNPELAEDAALIRAQAI---RCRDILRSM--------GRAGKEDTHLRQAPLEAVVR 290
Cdd:TIGR01386 249 AHELRTPLTNL-LGQTQVA--LSQPRTGEEYREVLESNLEeleRLSRMVSDMlflaradnGQLALERVRLDLAAELAKVA 325

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160  291 EAAEPhLARGREVVFAVgaepeNGE-EMDAQPLIHRRpeivhGLRNLIQNAVDFS--ESRVEIDLSWTADSVMVKIEDDG 367
Cdd:TIGR01386 326 EYFEP-LAEERGVRIRV-----EGEgLVRGDPQMFRR-----AISNLLSNALRHTpdGGTITVRIERRSDEVRVSVSNPG 394

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 516540160  368 PGFPPGLIGRIGDPFMR--SRRRPGYDGMGLGLFIAKTLLERSGARLS 413
Cdd:TIGR01386 395 PGIPPEHLSRLFDRFYRvdPARSNSGEGTGLGLAIVRSIMEAHGGRAS 442
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 335-420 7.37e-05

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 42.09  E-value: 7.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 335 NLIQNAVDFSES--RVEIDLSWT-ADSVMVKIEDDGPGFPPGLIGRIGDPFMR----SRRRPGydGMGLGLFIAKTLLER 407
Cdd:cd16925   11 NLLSNAFKFTPDggRIRCILEKFrLNRFLLTVSDSGPGIPPNLREEIFERFRQgdgsSTRAHG--GTGLGLSIVKEFVEL 88

                         90
                 ....*....|....*.
gi 516540160 408 SGARLSFAN---GGAQ 420
Cdd:cd16925   89 HGGTVTVSDapgGGAL 104
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 333-409 8.91e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 41.50  E-value: 8.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 333 LRNLIQNAVDFS--ESRVEIDLSWTADSVMVKIEDDGPGFPPGLIGRIGDP-FMRSRRRPGYDGMGLGLFIAKTLLERSG 409
Cdd:cd16948   10 IGQIVSNALKYSkqGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKgFTGENGRNFQESTGMGLYLVKKLCDKLG 89
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
183-398 1.66e-04

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 44.28  E-value: 1.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 183 YVRRVTIEMQAmgDALAAtqlALSREQKLTDLGGVVAAAAHELGTPLATItLTAAELADD-LSDNPELAEDAALIRAQAI 261
Cdd:PRK13837 424 AIERRRLETER--DALER---RLEHARRLEAVGTLASGIAHNFNNILGAI-LGYAEMALNkLARHSRAARYIDEIISAGA 497

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 262 RCRDILRSM---GRagKEDTHLRQAPLEAVVREAAePHL--ARGREVVFAVGAEPE----NGEEMDAQPLIHrrpeivhg 332
Cdd:PRK13837 498 RARLIIDQIlafGR--KGERNTKPFDLSELVTEIA-PLLrvSLPPGVELDFDQDQEpavvEGNPAELQQVLM-------- 566

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 333 lrNLIQNAVDFSE--SRVEIDLSW---------------TADSVMVKIEDDGPGFPPGLIGRIGDPFMRSRRrpgyDGMG 395
Cdd:PRK13837 567 --NLCSNAAQAMDgaGRVDISLSRaklrapkvlshgvlpPGRYVLLRVSDTGAGIDEAVLPHIFEPFFTTRA----GGTG 640


                 ...
gi 516540160 396 LGL 398
Cdd:PRK13837 641 LGL 643
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 218-413 1.89e-04

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 44.13  E-value: 1.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 218 VAAAAHELGTPLATITLTAAELADdlsdNPELAEDAALIRA--------QAIrCRDILR-SMGRAGKEDTHLRQAPLEAV 288
Cdd:PRK11466 448 LAAMSHEIRTPLYGILGTAQLLAD----NPALNAQRDDLRAitdsgeslLTI-LNDILDySAIEAGGKNVSVSDEPFEPR 522

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 289 VREAAEPHLARGREVVFAVGAEPENGEEMDA--QPLIHRRPEIVhglRNLIQNAVDFSEsRVEIDLSWTAD--SVMVKIE 364
Cdd:PRK11466 523 PLLESTLQLMSGRVKGRPIRLATDIADDLPTalMGDPRRIRQVI---TNLLSNALRFTD-EGSIVLRSRTDgeQWLVEVE 598

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 516540160 365 DDGPGFPPGLIGRIGDPFMRSRRRPGydGMGLGLFIAKTLLERSGARLS 413
Cdd:PRK11466 599 DSGCGIDPAKLAEIFQPFVQVSGKRG--GTGLGLTISSRLAQAMGGELS 645
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 333-416 3.18e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 40.14  E-value: 3.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 333 LRNLIQNAVDFSESRVEIDLSWTADS--VMVKIEDDGPGFPPGLIGRIGDPFMrSRRRP--GYDGMGLGLFIAKTLLERS 408
Cdd:cd16945    9 INNLLDNAIDFSPEGGLIALQLEADTegIELLVFDEGSGIPDYALNRVFERFY-SLPRPhsGQKSTGLGLAFVQEVAQLH 87


                 ....*...
gi 516540160 409 GARLSFAN 416
Cdd:cd16945   88 GGRITLRN 95
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 333-414 3.40e-04

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 42.98  E-value: 3.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 333 LRNLIQNAVD----FSESRVEIDLSWTADSVMVKIEDDGPGFPPGLIGRIgdpFMRsrrrpGY----DGMGLGLFIAKTL 404
Cdd:PRK11086 438 LGNLIENALEavggEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAI---FDK-----GYstkgSNRGVGLYLVKQS 509

                         90
                 ....*....|
gi 516540160 405 LERSGARLSF 414
Cdd:PRK11086 510 VENLGGSIAV 519
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 333-413 5.70e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 39.80  E-value: 5.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 333 LRNLIQNAVDFSESRVEIDLSWTAD--SVMVKIEDDGPGFPPGLIGRIGDPF--MRSRRRPGYDGMGLGLFIAKTLLERS 408
Cdd:cd16947   25 LKNLISNAIKYGSDGKFLGMTLREDekHVYIDIWDKGKGISETEKDHVFERLytLEDSRNSAKQGNGLGLTITKRLAESM 104


                 ....*
gi 516540160 409 GARLS 413
Cdd:cd16947  105 GGSIY 109
HATPase_c_2 pfam13581
Histidine kinase-like ATPase domain;
339-404 4.76e-03

Histidine kinase-like ATPase domain;


Pssm-ID: 433327 [Multi-domain]  Cd Length: 127  Bit Score: 37.27  E-value: 4.76e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 516540160  339 NAV-----DFSESRVEIDLSWTADSVMVKIEDDGPGFPPGLIGRIGDPFMRSRRRPGydgmGLGLFIAKTL 404
Cdd:pfam13581  42 NAVehayrEGPEGPVEVRLTSDGGGLVVTVADSGPPFDPLTLPPPDLEEPDEDRKEG----GRGLALIRGL 108
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
320-398 5.70e-03

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 38.85  E-value: 5.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516540160 320 QPLIhrrpE--IVHGLRNLIQNAvdfsesRVEIDLSWTADSVMVKIEDDGPGFPPGLIGRIgdpfmRSRRRPGYDGMGLG 397
Cdd:COG2972  342 QPLV----EnaIEHGIEPKEGGG------TIRISIRKEGDRLVITVEDNGVGMPEEKLEKL-----LEELSSKGEGRGIG 406


                 .
gi 516540160 398 L 398
Cdd:COG2972  407 L 407
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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