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Conserved domains on  [gi|516413859|ref|WP_017803257|]
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ribose 5-phosphate isomerase B [Erwinia toletana]

Protein Classification

RpiB/LacA/LacB family sugar-phosphate isomerase( domain architecture ID 10012451)

RpiB/LacA/LacB family sugar-phosphate isomerase similar to ribose 5-phosphate isomerase B, which catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK05571 PRK05571
ribose-5-phosphate isomerase B; Provisional
 4-148 5.97e-75

ribose-5-phosphate isomerase B; Provisional


:

Pssm-ID: 235509  Cd Length: 148  Bit Score: 220.03  E-value: 5.97e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516413859   4 IAIGADDAALELKNLIKQFLQEKNIAVSDYSNDAQAAKPLYPDIAWTLANAIREGKHQRGILICGTGIGMAIVANKVPGI 83
Cdd:PRK05571   3 IAIGSDHAGFELKEEIIEHLEELGHEVIDLGPDSYDASVDYPDYAKKVAEAVVAGEADRGILICGTGIGMSIAANKVKGI 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 516413859  84 RAAQCHDTYSAERARKSNNAQVITLGARVIGPELARSIVNSWLNSEFEGGGSSEKVDKISYYEQS 148
Cdd:PRK05571  83 RAALCHDTYSAHLAREHNNANVLALGARVIGPELAKDIVDAFLATEFEGGRHQRRIDKIDEYEAQ 147
 
Name Accession Description Interval E-value
PRK05571 PRK05571
ribose-5-phosphate isomerase B; Provisional
 4-148 5.97e-75

ribose-5-phosphate isomerase B; Provisional


Pssm-ID: 235509  Cd Length: 148  Bit Score: 220.03  E-value: 5.97e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516413859   4 IAIGADDAALELKNLIKQFLQEKNIAVSDYSNDAQAAKPLYPDIAWTLANAIREGKHQRGILICGTGIGMAIVANKVPGI 83
Cdd:PRK05571   3 IAIGSDHAGFELKEEIIEHLEELGHEVIDLGPDSYDASVDYPDYAKKVAEAVVAGEADRGILICGTGIGMSIAANKVKGI 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 516413859  84 RAAQCHDTYSAERARKSNNAQVITLGARVIGPELARSIVNSWLNSEFEGGGSSEKVDKISYYEQS 148
Cdd:PRK05571  83 RAALCHDTYSAHLAREHNNANVLALGARVIGPELAKDIVDAFLATEFEGGRHQRRIDKIDEYEAQ 147
RpiB COG0698
Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Ribose 5-phosphate ...
 4-147 4.78e-73

Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Ribose 5-phosphate isomerase RpiB is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440462  Cd Length: 149  Bit Score: 215.33  E-value: 4.78e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516413859   4 IAIGADDAALELKNLIKQFLQEKNIAVSDYSNDAQAAKPlYPDIAWTLANAIREGKHQRGILICGTGIGMAIVANKVPGI 83
Cdd:COG0698    3 IAIGSDHAGFELKEAIKEYLEEKGHEVVDFGTYSEDSVD-YPDFAIKVAEAVASGEADRGILICGTGIGMSIAANKVPGI 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 516413859  84 RAAQCHDTYSAERARKSNNAQVITLGARVIGPELARSIVNSWLNSEFEGGGSSEKVDKISYYEQ 147
Cdd:COG0698   82 RAALCHDPYSARLAREHNDANVLCLGARVIGPELAKEIVDAFLATEFEGGRHQRRVDKISELEK 145
LacAB_rpiB pfam02502
Ribose/Galactose Isomerase; This family of proteins contains the sugar isomerase enzymes ...
 4-133 1.01e-67

Ribose/Galactose Isomerase; This family of proteins contains the sugar isomerase enzymes ribose 5-phosphate isomerase B (rpiB), galactose isomerase subunit A (LacA) and galactose isomerase subunit B (LacB).


Pssm-ID: 460573  Cd Length: 134  Bit Score: 201.46  E-value: 1.01e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516413859    4 IAIGADDAALELKNLIKQFLQEKNIAVSDYSNDAQAAKPlYPDIAWTLANAIREGKHQRGILICGTGIGMAIVANKVPGI 83
Cdd:pfam02502   1 IAIGSDHAGFELKEEIKEYLEEKGHEVIDFGTYSEESVD-YPDYAHKVAEAVASGEADRGILICGTGIGMSIAANKVPGI 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 516413859   84 RAAQCHDTYSAERARKSNNAQVITLGARVIGPELARSIVNSWLNSEFEGG 133
Cdd:pfam02502  80 RAALCHDPYSAKLAREHNDANVLCLGARVIGPELAKEIVDAFLNTEFEGG 129
rpiB_lacA_lacB TIGR00689
sugar-phosphate isomerase, RpiB/LacA/LacB family; Proteins of known function in this family ...
 4-148 3.20e-52

sugar-phosphate isomerase, RpiB/LacA/LacB family; Proteins of known function in this family act as sugar (pentose and/or hexose)-phosphate isomerases, including the LacA and LacB subunits of galactose-6-phosphate isomerases from Gram-positive bacteria and RpiB. RpiB is the second ribose phosphate isomerase of E. coli. It lacks homology to RpiA, its inducer is unknown (but is not ribose), and it can be replaced by the homologous galactose-6-phosphate isomerase of Streptococcus mutans, all of which suggests that the ribose phosphate isomerase activity of RpiB is a secondary function. On the other hand, there appear to be a significant number of species which contain rpiB, lack rpiA and seem to require rpi activity in order to complete the pentose phosphate pathway.


Pssm-ID: 129772  Cd Length: 144  Bit Score: 162.55  E-value: 3.20e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516413859    4 IAIGADDAALELKNLIKQFLQEKNIAVSDYSNDAQAAKPlYPDIAWTLANAIREGKHQRGILICGTGIGMAIVANKVPGI 83
Cdd:TIGR00689   1 IAIGSDHAGLELKSEIIEHLKQKGHEVIDCGTLYDERVD-YPDYAKLVADKVVAGEVSLGILICGTGIGMSIAANKFKGI 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 516413859   84 RAAQCHDTYSAERARKSNNAQVITLGARVIGPELARSIVNSWLNSEFEGGGSSEKVDKISYYEQS 148
Cdd:TIGR00689  80 RAALCVDEYTAALARQHNDANVLCLGSRVVGVELALSIVDAFLTTQFEGGRHQRRIDKIIEYERE 144
 
Name Accession Description Interval E-value
PRK05571 PRK05571
ribose-5-phosphate isomerase B; Provisional
 4-148 5.97e-75

ribose-5-phosphate isomerase B; Provisional


Pssm-ID: 235509  Cd Length: 148  Bit Score: 220.03  E-value: 5.97e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516413859   4 IAIGADDAALELKNLIKQFLQEKNIAVSDYSNDAQAAKPLYPDIAWTLANAIREGKHQRGILICGTGIGMAIVANKVPGI 83
Cdd:PRK05571   3 IAIGSDHAGFELKEEIIEHLEELGHEVIDLGPDSYDASVDYPDYAKKVAEAVVAGEADRGILICGTGIGMSIAANKVKGI 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 516413859  84 RAAQCHDTYSAERARKSNNAQVITLGARVIGPELARSIVNSWLNSEFEGGGSSEKVDKISYYEQS 148
Cdd:PRK05571  83 RAALCHDTYSAHLAREHNNANVLALGARVIGPELAKDIVDAFLATEFEGGRHQRRIDKIDEYEAQ 147
RpiB COG0698
Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Ribose 5-phosphate ...
 4-147 4.78e-73

Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Ribose 5-phosphate isomerase RpiB is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440462  Cd Length: 149  Bit Score: 215.33  E-value: 4.78e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516413859   4 IAIGADDAALELKNLIKQFLQEKNIAVSDYSNDAQAAKPlYPDIAWTLANAIREGKHQRGILICGTGIGMAIVANKVPGI 83
Cdd:COG0698    3 IAIGSDHAGFELKEAIKEYLEEKGHEVVDFGTYSEDSVD-YPDFAIKVAEAVASGEADRGILICGTGIGMSIAANKVPGI 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 516413859  84 RAAQCHDTYSAERARKSNNAQVITLGARVIGPELARSIVNSWLNSEFEGGGSSEKVDKISYYEQ 147
Cdd:COG0698   82 RAALCHDPYSARLAREHNDANVLCLGARVIGPELAKEIVDAFLATEFEGGRHQRRVDKISELEK 145
LacAB_rpiB pfam02502
Ribose/Galactose Isomerase; This family of proteins contains the sugar isomerase enzymes ...
 4-133 1.01e-67

Ribose/Galactose Isomerase; This family of proteins contains the sugar isomerase enzymes ribose 5-phosphate isomerase B (rpiB), galactose isomerase subunit A (LacA) and galactose isomerase subunit B (LacB).


Pssm-ID: 460573  Cd Length: 134  Bit Score: 201.46  E-value: 1.01e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516413859    4 IAIGADDAALELKNLIKQFLQEKNIAVSDYSNDAQAAKPlYPDIAWTLANAIREGKHQRGILICGTGIGMAIVANKVPGI 83
Cdd:pfam02502   1 IAIGSDHAGFELKEEIKEYLEEKGHEVIDFGTYSEESVD-YPDYAHKVAEAVASGEADRGILICGTGIGMSIAANKVPGI 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 516413859   84 RAAQCHDTYSAERARKSNNAQVITLGARVIGPELARSIVNSWLNSEFEGG 133
Cdd:pfam02502  80 RAALCHDPYSAKLAREHNDANVLCLGARVIGPELAKEIVDAFLNTEFEGG 129
rpiB_lacA_lacB TIGR00689
sugar-phosphate isomerase, RpiB/LacA/LacB family; Proteins of known function in this family ...
 4-148 3.20e-52

sugar-phosphate isomerase, RpiB/LacA/LacB family; Proteins of known function in this family act as sugar (pentose and/or hexose)-phosphate isomerases, including the LacA and LacB subunits of galactose-6-phosphate isomerases from Gram-positive bacteria and RpiB. RpiB is the second ribose phosphate isomerase of E. coli. It lacks homology to RpiA, its inducer is unknown (but is not ribose), and it can be replaced by the homologous galactose-6-phosphate isomerase of Streptococcus mutans, all of which suggests that the ribose phosphate isomerase activity of RpiB is a secondary function. On the other hand, there appear to be a significant number of species which contain rpiB, lack rpiA and seem to require rpi activity in order to complete the pentose phosphate pathway.


Pssm-ID: 129772  Cd Length: 144  Bit Score: 162.55  E-value: 3.20e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516413859    4 IAIGADDAALELKNLIKQFLQEKNIAVSDYSNDAQAAKPlYPDIAWTLANAIREGKHQRGILICGTGIGMAIVANKVPGI 83
Cdd:TIGR00689   1 IAIGSDHAGLELKSEIIEHLKQKGHEVIDCGTLYDERVD-YPDYAKLVADKVVAGEVSLGILICGTGIGMSIAANKFKGI 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 516413859   84 RAAQCHDTYSAERARKSNNAQVITLGARVIGPELARSIVNSWLNSEFEGGGSSEKVDKISYYEQS 148
Cdd:TIGR00689  80 RAALCVDEYTAALARQHNDANVLCLGSRVVGVELALSIVDAFLTTQFEGGRHQRRIDKIIEYERE 144
PTZ00215 PTZ00215
ribose 5-phosphate isomerase; Provisional
 4-148 2.60e-44

ribose 5-phosphate isomerase; Provisional


Pssm-ID: 185516  Cd Length: 151  Bit Score: 142.47  E-value: 2.60e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516413859   4 IAIGADDAALELKNLIKQFLQEKN-----IAVSDYSNDAQAakplYPDIAWTLANAIREGKHQRGILICGTGIGMAIVAN 78
Cdd:PTZ00215   5 VAIGSDHAGFDLKNEIIDYIKNKGkeykiEDMGTYTAESVD----YPDFAEKVCEEVLKGEADTGILVCGSGIGISIAAN 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516413859  79 KVPGIRAAQCHDTYSAERARKSNNAQVITLGARVIGPELARSIVNSWLNSEFEGGGSSEKVDKISYYEQS 148
Cdd:PTZ00215  81 KVKGIRCALCHDHYTARMSRQHNNANVLAFGGRTTGIEVAKEIIDTFLSTPFEGGRHTERIDKISAIEEE 150
rpiB TIGR01120
ribose 5-phosphate isomerase B; Involved in the non-oxidative branch of the pentose phospate ...
 4-143 2.57e-42

ribose 5-phosphate isomerase B; Involved in the non-oxidative branch of the pentose phospate pathway. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 130190  Cd Length: 143  Bit Score: 137.35  E-value: 2.57e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516413859    4 IAIGADDAALELKNLIKQFLQEKNIAVSDYSNDAQAAKPlYPDIAWTLANAIREGKHQRGILICGTGIGMAIVANKVPGI 83
Cdd:TIGR01120   2 IAIGSDHAGFILKEEIKAFLVERGVKVIDKGTWSSERTD-YPHYAKQVALAVAGGEVDGGILICGTGIGMSIAANKFAGI 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 516413859   84 RAAQCHDTYSAERARKSNNAQVITLGARVIGPELARSIVNSWLNSEFEGGGSSEKVDKIS 143
Cdd:TIGR01120  81 RAALCSEPYMAQMSRLHNDANVLCLGERVVGLELAKSIVDAWLGTQFEGGRHQQRVEAIT 140
RPI_actino TIGR02133
ribose 5-phosphate isomerase; This family is a member of the RpiB/LacA/LacB subfamily ...
 4-146 7.59e-34

ribose 5-phosphate isomerase; This family is a member of the RpiB/LacA/LacB subfamily (TIGR00689) but lies outside the RpiB equivalog (TIGR01120) which is also a member of that subfamily. Ribose 5-phosphate isomerase is an essential enzyme of the pentose phosphate pathway; a pathway that appears to be present in the actinobacteria. The only candidates for ribose 5-phosphate isomerase in the Actinobacteria are members of this family.


Pssm-ID: 273989  Cd Length: 148  Bit Score: 116.02  E-value: 7.59e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516413859    4 IAIGADDAALELKNLIKQFLQEKNIAVSD-YSNDAQAAKPlYPDIAWTLANAIREGKHQRGILICGTGIGMAIVANKVPG 82
Cdd:TIGR02133   3 VVLGHDHAGFEYKEALWLDLAAHEPEVCDvGVYDADDDDD-YPCFCIAAAEAVARDAADLGIVIGGSGNGEAIAANKVKG 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 516413859   83 IRAAQCHDTYSAERARKSNNAQVITLGARVIGPELARSIVNSWLNSEFEGGG-SSEKVDKISYYE 146
Cdd:TIGR02133  82 ARAALAWDTASAGRARLHNNANVVGAGMRMHGLEEAFRLVFEFLGFEFDARSrHARRIDSISEYE 146
PRK08621 PRK08621
galactose-6-phosphate isomerase subunit LacA; Reviewed
 4-140 1.40e-27

galactose-6-phosphate isomerase subunit LacA; Reviewed


Pssm-ID: 181505  Cd Length: 142  Bit Score: 99.79  E-value: 1.40e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516413859   4 IAIGADDAALELKNLIKQFLQEKNIAVSDYSNDAQAAkplYPDIAWTLANAIREGKHQRGILICGTGIGMAIVANKVPGI 83
Cdd:PRK08621   3 IIIGADKAGFELKEVVKDYLEDNKYEVVDVTEEGAED---FVDSTLAVAKEVNKSEDNLGIVIDAYGAGSFMVATKIKGM 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 516413859  84 RAAQCHDTYSAERARKSNNAQVITLGARVIGPELARSIVNSWLNSEFEGGGSSEKVD 140
Cdd:PRK08621  80 VAAEVSDERSAYMTRGHNNARMITMGSEIVGDGLAKNIIKGFVEGKYDGGRHQIRVD 136
PRK08622 PRK08622
galactose-6-phosphate isomerase subunit LacB; Reviewed
 4-142 4.47e-24

galactose-6-phosphate isomerase subunit LacB; Reviewed


Pssm-ID: 181506  Cd Length: 171  Bit Score: 91.63  E-value: 4.47e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516413859   4 IAIGADDAALELKNLIKQFLQEKNIAVSD---YSNdaqaAKPLYPDIAWTLANAIREGKHQRGILICGTGIGMAIVANKV 80
Cdd:PRK08622   3 IAIGCDHIVTDEKMAVSDYLKSKGHEVIDvgtYDF----TRTHYPIFGKKVGEAVASGEADLGVCICGTGVGISNAVNKV 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 516413859  81 PGIRAAQCHDTYSAERARKSNNAQVITLGARVIGPELARSIVNSWLNSEFEGGGSSEK-VDKI 142
Cdd:PRK08622  79 PGIRSALVRDMTSALYAKEELNANVIGFGGKITGELLMCDIIDAFINAEYKPTEENKKlIEKI 141
PRK12613 PRK12613
galactose-6-phosphate isomerase subunit LacA; Provisional
 3-140 7.51e-24

galactose-6-phosphate isomerase subunit LacA; Provisional


Pssm-ID: 171609  Cd Length: 141  Bit Score: 90.37  E-value: 7.51e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516413859   3 SIAIGADDAALELKNLIKQFLQEKNIAVSDYSNDAQAakplYPDIAWTLANAIREGKHQRGILICGTGIGMAIVANKVPG 82
Cdd:PRK12613   2 AIILGADAHGNALKELIKSFLQEEGYDIIDVTDINSD----FIDNTLAVAKAVNEAEGRLGIMVDAYGAGPFMVATKLKG 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 516413859  83 IRAAQCHDTYSAERARKSNNAQVITLGARVIGPELARSIVNSWLNSEFEGGGSSEKVD 140
Cdd:PRK12613  78 MVAAEVSDERSAYMTRGHNNARMITMGAEIVGPELAKNIAKGFVTGPYDGGRHQIRVD 135
PRK12615 PRK12615
galactose-6-phosphate isomerase subunit LacB; Reviewed
 4-146 5.09e-19

galactose-6-phosphate isomerase subunit LacB; Reviewed


Pssm-ID: 171610  Cd Length: 171  Bit Score: 78.53  E-value: 5.09e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516413859   4 IAIGADDAALELKNLIKQFLQEKNIAVSDYSNdAQAAKPLYPDIAWTLANAIREGKHQRGILICGTGIGMAIVANKVPGI 83
Cdd:PRK12615   3 IAIGCDHIVTNEKMAVSDFLKSKGYDVIDCGT-YDHTRTHYPIFGKKVGEAVVNGQADLGVCICGTGVGINNAVNKVPGI 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 516413859  84 RAAQCHDTYSAERARKSNNAQVITLGARVIGPELARSIVNSWLNSEFEGGGSSEK-VDKISYYE 146
Cdd:PRK12615  82 RSALVRDMTTALYAKEELNANVIGFGGKITGELLMCDIIDAFIKAEYKETEENKKlIAKIAHLE 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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