NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|516270832|ref|WP_017674795|]
View 

ArsC family reductase [Ectopseudomonas chengduensis]

Protein Classification

arsenate reductase( domain architecture ID 10122554)

glutathione dependent arsenate reductase family, Yffb subfamily protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ArsC_Yffb cd03035
Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein ...
 4-107 1.11e-61

Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine suggest that it is likely to function as a glutathione (GSH)-dependent thiol reductase. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from GSH via glutaredoxin, through a single catalytic cysteine.


:

Pssm-ID: 239333  Cd Length: 105  Bit Score: 183.56  E-value: 1.11e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516270832   4 VLYGIKACDTMKKARTWLDEHQVDYAFHDYKSVGIDRANLEKWCNEHGWQTVLNRAGTTFRKLEDAQKADLDQVKAIELM 83
Cdd:cd03035    2 TLYGIKNCDTVKKARKWLEARGVAYTFHDYRKDGLDAATLERWLAKVGWETLLNKRGTTWRKLDDAQKAALDAAKAIALM 81

                         90       100
                 ....*....|....*....|....
gi 516270832  84 LAQPSMIKRPVLDLGDKTLVGFKP 107
Cdd:cd03035   82 LEHPSLIKRPVLETGGKVLVGFSE 105
 
Name Accession Description Interval E-value
ArsC_Yffb cd03035
Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein ...
 4-107 1.11e-61

Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine suggest that it is likely to function as a glutathione (GSH)-dependent thiol reductase. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from GSH via glutaredoxin, through a single catalytic cysteine.


Pssm-ID: 239333  Cd Length: 105  Bit Score: 183.56  E-value: 1.11e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516270832   4 VLYGIKACDTMKKARTWLDEHQVDYAFHDYKSVGIDRANLEKWCNEHGWQTVLNRAGTTFRKLEDAQKADLDQVKAIELM 83
Cdd:cd03035    2 TLYGIKNCDTVKKARKWLEARGVAYTFHDYRKDGLDAATLERWLAKVGWETLLNKRGTTWRKLDDAQKAALDAAKAIALM 81

                         90       100
                 ....*....|....*....|....
gi 516270832  84 LAQPSMIKRPVLDLGDKTLVGFKP 107
Cdd:cd03035   82 LEHPSLIKRPVLETGGKVLVGFSE 105
PRK10853 PRK10853
putative reductase; Provisional
 4-111 1.49e-44

putative reductase; Provisional


Pssm-ID: 182780  Cd Length: 118  Bit Score: 140.57  E-value: 1.49e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516270832   4 VLYGIKACDTMKKARTWLDEHQVDYAFHDYKSVGIDRANLEKWCNEHGWQTVLNRAGTTFRKLEDAQKADL-DQVKAIEL 82
Cdd:PRK10853   3 TLYGIKNCDTIKKARRWLEAQGIDYRFHDYRVDGLDSELLQGFIDELGWEALLNTRGTTWRKLDETQRNAItDAASAAAL 82

                         90       100       110
                 ....*....|....*....|....*....|
gi 516270832  83 MLAQPSMIKRPVLDLGDKT-LVGFKPDNYQ 111
Cdd:PRK10853  83 MLEQPAIIKRPLLCAPGKPmLLGFSESSYQ 112
ArsC COG1393
Arsenate reductase or related protein, glutaredoxin family [Inorganic ion transport and ...
 4-115 1.06e-43

Arsenate reductase or related protein, glutaredoxin family [Inorganic ion transport and metabolism];


Pssm-ID: 441003  Cd Length: 115  Bit Score: 138.30  E-value: 1.06e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516270832   4 VLYGIKACDTMKKARTWLDEHQVDYAFHDYKSVGIDRANLEKWCN--EHGWQTVLNRAGTTFRKLEDAQKAdLDQVKAIE 81
Cdd:COG1393    3 TIYGNPNCSTSRKALAWLEEAGIEYEFIDYLKTPPTAEELKELLAklGLGVEELLNTRGTTYRELGLKDKA-LSEEEALA 81

                         90       100       110
                 ....*....|....*....|....*....|....
gi 516270832  82 LMLAQPSMIKRPVLDLGDKTLVGFKPDNYQAALA 115
Cdd:COG1393   82 LMLEHPSLIKRPIVVTGDKALVGFPPEEVLALLG 115
ArsC pfam03960
ArsC family; This family is related to glutaredoxins pfam00462.
 6-113 1.23e-40

ArsC family; This family is related to glutaredoxins pfam00462.


Pssm-ID: 427617  Cd Length: 109  Bit Score: 130.41  E-value: 1.23e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516270832    6 YGIKACDTMKKARTWLDEHQVDYAFHDYKSVGIDRANLEKWCNEH--GWQTVLNRAGTTFRKLeDAQKADLDQVKAIELM 83
Cdd:pfam03960   1 YGSPNCSTCRKALAWLEEHGIEYQEIDYLETPPSKEELKDILAKLgdGVEALLNTRGTTYREL-NLDKEDLSEDELLELI 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 516270832   84 LAQPSMIKRPVLDLGDKTLVGFKPDNYQAA 113
Cdd:pfam03960  80 LEHPSLIRRPIVVDGGKLLVGFNEEEIRAF 109
arsC_related TIGR01617
transcriptional regulator, Spx/MgsR family; This model represents a portion of the proteins ...
 5-111 1.25e-30

transcriptional regulator, Spx/MgsR family; This model represents a portion of the proteins within the larger set covered by pfam03960. That larger family includes a glutaredoxin-dependent arsenate reductase (TIGR00014). Characterized members of this family include Spx and MgsR from Bacillus subtili. Spx is a global regulator for response to thiol-specific oxidative stress. It interacts with RNA polymerase. MgsR (modulator of the general stress response, also called YqgZ) provides a second level of regulation for more than a third of the proteins in the B. subtilis general stress regulon controlled by Sigma-B. [Regulatory functions, DNA interactions]


Pssm-ID: 273720  Cd Length: 117  Bit Score: 105.20  E-value: 1.25e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516270832    5 LYGIKACDTMKKARTWLDEHQVDYAFHDYKSVGIDRANLEKWCN--EHGWQTVLNRAGTTFRKLEDAQK-ADLDQVKAIE 81
Cdd:TIGR01617   3 VYGSPNCTTCKKARRWLEANGIEYQFIDIGEDGPTREELLDILSllEDGIDPLLNTRGQSYRALNTSNTfLDLSDKEALE 82

                          90       100       110
                  ....*....|....*....|....*....|.
gi 516270832   82 LMLAQPSMIKRPVL-DLGDKTLVGFKPDNYQ 111
Cdd:TIGR01617  83 LLAEDPALLRRPLIvDTKNRLLIGFKSESIE 113
 
Name Accession Description Interval E-value
ArsC_Yffb cd03035
Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein ...
 4-107 1.11e-61

Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine suggest that it is likely to function as a glutathione (GSH)-dependent thiol reductase. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from GSH via glutaredoxin, through a single catalytic cysteine.


Pssm-ID: 239333  Cd Length: 105  Bit Score: 183.56  E-value: 1.11e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516270832   4 VLYGIKACDTMKKARTWLDEHQVDYAFHDYKSVGIDRANLEKWCNEHGWQTVLNRAGTTFRKLEDAQKADLDQVKAIELM 83
Cdd:cd03035    2 TLYGIKNCDTVKKARKWLEARGVAYTFHDYRKDGLDAATLERWLAKVGWETLLNKRGTTWRKLDDAQKAALDAAKAIALM 81

                         90       100
                 ....*....|....*....|....
gi 516270832  84 LAQPSMIKRPVLDLGDKTLVGFKP 107
Cdd:cd03035   82 LEHPSLIKRPVLETGGKVLVGFSE 105
PRK10853 PRK10853
putative reductase; Provisional
 4-111 1.49e-44

putative reductase; Provisional


Pssm-ID: 182780  Cd Length: 118  Bit Score: 140.57  E-value: 1.49e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516270832   4 VLYGIKACDTMKKARTWLDEHQVDYAFHDYKSVGIDRANLEKWCNEHGWQTVLNRAGTTFRKLEDAQKADL-DQVKAIEL 82
Cdd:PRK10853   3 TLYGIKNCDTIKKARRWLEAQGIDYRFHDYRVDGLDSELLQGFIDELGWEALLNTRGTTWRKLDETQRNAItDAASAAAL 82

                         90       100       110
                 ....*....|....*....|....*....|
gi 516270832  83 MLAQPSMIKRPVLDLGDKT-LVGFKPDNYQ 111
Cdd:PRK10853  83 MLEQPAIIKRPLLCAPGKPmLLGFSESSYQ 112
ArsC COG1393
Arsenate reductase or related protein, glutaredoxin family [Inorganic ion transport and ...
 4-115 1.06e-43

Arsenate reductase or related protein, glutaredoxin family [Inorganic ion transport and metabolism];


Pssm-ID: 441003  Cd Length: 115  Bit Score: 138.30  E-value: 1.06e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516270832   4 VLYGIKACDTMKKARTWLDEHQVDYAFHDYKSVGIDRANLEKWCN--EHGWQTVLNRAGTTFRKLEDAQKAdLDQVKAIE 81
Cdd:COG1393    3 TIYGNPNCSTSRKALAWLEEAGIEYEFIDYLKTPPTAEELKELLAklGLGVEELLNTRGTTYRELGLKDKA-LSEEEALA 81

                         90       100       110
                 ....*....|....*....|....*....|....
gi 516270832  82 LMLAQPSMIKRPVLDLGDKTLVGFKPDNYQAALA 115
Cdd:COG1393   82 LMLEHPSLIKRPIVVTGDKALVGFPPEEVLALLG 115
ArsC pfam03960
ArsC family; This family is related to glutaredoxins pfam00462.
 6-113 1.23e-40

ArsC family; This family is related to glutaredoxins pfam00462.


Pssm-ID: 427617  Cd Length: 109  Bit Score: 130.41  E-value: 1.23e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516270832    6 YGIKACDTMKKARTWLDEHQVDYAFHDYKSVGIDRANLEKWCNEH--GWQTVLNRAGTTFRKLeDAQKADLDQVKAIELM 83
Cdd:pfam03960   1 YGSPNCSTCRKALAWLEEHGIEYQEIDYLETPPSKEELKDILAKLgdGVEALLNTRGTTYREL-NLDKEDLSEDELLELI 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 516270832   84 LAQPSMIKRPVLDLGDKTLVGFKPDNYQAA 113
Cdd:pfam03960  80 LEHPSLIRRPIVVDGGKLLVGFNEEEIRAF 109
ArsC_family cd02977
Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins ...
 4-105 2.87e-40

Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from glutathione (GSH) via glutaredoxin (GRX), through a single catalytic cysteine. This family of predominantly bacterial enzymes is unrelated to two other families of arsenate reductases which show similarity to low-molecular-weight acid phosphatases and phosphotyrosyl phosphatases. Spx is a general regulator that exerts negative and positive control over transcription initiation by binding to the C-terminal domain of the alpha subunit of RNA polymerase.


Pssm-ID: 239275  Cd Length: 105  Bit Score: 129.15  E-value: 2.87e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516270832   4 VLYGIKACDTMKKARTWLDEHQVDYAFHDYKSVGIDRANLEKWCN--EHGWQTVLNRAGTTFRKLEDAQKADLDQVKAIE 81
Cdd:cd02977    2 TIYGNPNCSTSRKALAWLEEHGIEYEFIDYLKEPPTKEELKELLAklGLGVEDLFNTRGTPYRKLGLADKDELSDEEALE 81

                         90       100
                 ....*....|....*....|....
gi 516270832  82 LMLAQPSMIKRPVLDLGDKTLVGF 105
Cdd:cd02977   82 LMAEHPKLIKRPIVVDGDRLLVGF 105
arsC_related TIGR01617
transcriptional regulator, Spx/MgsR family; This model represents a portion of the proteins ...
 5-111 1.25e-30

transcriptional regulator, Spx/MgsR family; This model represents a portion of the proteins within the larger set covered by pfam03960. That larger family includes a glutaredoxin-dependent arsenate reductase (TIGR00014). Characterized members of this family include Spx and MgsR from Bacillus subtili. Spx is a global regulator for response to thiol-specific oxidative stress. It interacts with RNA polymerase. MgsR (modulator of the general stress response, also called YqgZ) provides a second level of regulation for more than a third of the proteins in the B. subtilis general stress regulon controlled by Sigma-B. [Regulatory functions, DNA interactions]


Pssm-ID: 273720  Cd Length: 117  Bit Score: 105.20  E-value: 1.25e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516270832    5 LYGIKACDTMKKARTWLDEHQVDYAFHDYKSVGIDRANLEKWCN--EHGWQTVLNRAGTTFRKLEDAQK-ADLDQVKAIE 81
Cdd:TIGR01617   3 VYGSPNCTTCKKARRWLEANGIEYQFIDIGEDGPTREELLDILSllEDGIDPLLNTRGQSYRALNTSNTfLDLSDKEALE 82

                          90       100       110
                  ....*....|....*....|....*....|.
gi 516270832   82 LMLAQPSMIKRPVL-DLGDKTLVGFKPDNYQ 111
Cdd:TIGR01617  83 LLAEDPALLRRPLIvDTKNRLLIGFKSESIE 113
ArsC_like cd03036
Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a ...
 3-110 3.77e-14

Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX) function as protein disulfide oxidoreductases, altering the redox state of target proteins via the reversible oxidation of the active site dithiol. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from glutathione via GRX, through a single catalytic cysteine.


Pssm-ID: 239334  Cd Length: 111  Bit Score: 63.03  E-value: 3.77e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516270832   3 YVLYGIKACDTMKKARTWLDEHQVDYAFHDYKSVGIDRANLEKWCNEHGW--QTVLNRAGTTFRKLEDAQKAD-LDQVKA 79
Cdd:cd03036    1 LKFYEYPKCSTCRKAKKWLDEHGVDYTAIDIVEEPPSKEELKKWLEKSGLplKKFFNTSGKSYRELGLKDKLPsLSEEEA 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 516270832  80 IELMLAQPSMIKRPVLDLGDKTLVGFKPDNY 110
Cdd:cd03036   81 LELLSSDGMLIKRPFVVDDDKVLVGFKEEEW 111
ArsC_Spx cd03032
Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding ...
 4-108 8.52e-11

Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex formation between RNAP and certain transcriptional activator proteins like ResD and ComA. In response to oxidative stress, Spx can also activate transcription, making it a general regulator that exerts both positive and negative control over transcription initiation. Spx has been shown to exert redox-sensitive transcriptional control over genes like trxA (TRX) and trxB (TRX reductase), genes that function in thiol homeostasis. This redox-sensitive activity is dependent on the presence of a CXXC motif, present in some members of the Spx subfamily, that acts as a thiol/disulfide switch. Spx has also been shown to repress genes in a sulfate-dependent manner independent of the presence of the CXXC motif.


Pssm-ID: 239330  Cd Length: 115  Bit Score: 54.56  E-value: 8.52e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516270832   4 VLYGIKACDTMKKARTWLDEHQVDYAFHDYKSVGIDRANLEKWCN--EHGWQTVLNRAGTTFRKLedaqKADLDQV---K 78
Cdd:cd03032    3 KLYTSPSCSSCRKAKQWLEEHQIPFEERNLFKQPLTKEELKEILSltENGVEDIISTRSKAFKNL----NIDIDELslsE 78

                         90       100       110
                 ....*....|....*....|....*....|
gi 516270832  79 AIELMLAQPSMIKRPVLDLGDKTLVGFKPD 108
Cdd:cd03032   79 LIRLISEHPSLLRRPIIIDEKRLQIGYNED 108
spxA PRK13344
transcriptional regulator Spx; Reviewed
 5-114 3.65e-10

transcriptional regulator Spx; Reviewed


Pssm-ID: 183988  Cd Length: 132  Bit Score: 53.43  E-value: 3.65e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516270832   5 LYGIKACDTMKKARTWLDEHQVDYAFHDYKSVGIDR----ANLEKwcNEHGWQTVLNrAGTTFRKLEDAQKADLDQVKAI 80
Cdd:PRK13344   4 IYTISSCTSCKKAKTWLNAHQLSYKEQNLGKEPLTKeeilAILTK--TENGIESIVS-SKNRYAKALDCDIEELSVNEVI 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 516270832  81 ELMLAQPSMIKRPVLdLGDKTL-VGFKPDNYQAAL 114
Cdd:PRK13344  81 DLIQENPRILKSPIL-IDDKRLqVGYKEDDIRAFL 114
PRK12559 PRK12559
transcriptional regulator Spx; Provisional
 4-114 4.79e-08

transcriptional regulator Spx; Provisional


Pssm-ID: 79035  Cd Length: 131  Bit Score: 47.79  E-value: 4.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516270832   4 VLYGIKACDTMKKARTWLDEHQVDYAFHDY--KSVGIDRANLEKWCNEHGWQTVLNRAGTTFRKLedaqKADLDQVKAIE 81
Cdd:PRK12559   3 VLYTTASCASCRKAKAWLEENQIDYTEKNIvsNSMTVDELKSILRLTEEGATEIISTRSKTFQDL----NINIEELSLNE 78

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 516270832  82 ---LMLAQPSMIKRPVLdLGDKTL-VGFKPDNYQAAL 114
Cdd:PRK12559  79 fykLIIEHPLMLRRPIM-LDEKRLqIGFNDEEIRKFL 114
ArsC_15kD cd03033
Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown ...
 74-108 7.99e-07

Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also encodes dinitrogenase reductase ADP-ribosyltransferase (DRAT) and dinitrogenase reductase activating glycohydrolase (DRAG). ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from glutathione via glutaredoxin, through a single catalytic cysteine.


Pssm-ID: 239331  Cd Length: 113  Bit Score: 44.19  E-value: 7.99e-07
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 516270832  74 LDQVKAIELMLAQPSMIKRPVLDLGDKTLVGFKPD 108
Cdd:cd03033   72 LDEEEALALMIADPLLIRRPLMQVGDRRMVGFDTA 106
spxA PRK01655
transcriptional regulator Spx; Reviewed
 5-114 9.01e-06

transcriptional regulator Spx; Reviewed


Pssm-ID: 179316  Cd Length: 131  Bit Score: 41.60  E-value: 9.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516270832   5 LYGIKACDTMKKARTWLDEHQVDYAFHDYKSVGIDRANLEKWCN--EHGWQTVLNRAGTTFRKLEdaqkADLDQV---KA 79
Cdd:PRK01655   4 LFTSPSCTSCRKAKAWLEEHDIPFTERNIFSSPLTIDEIKQILRmtEDGTDEIISTRSKVFQKLN----VDVESLslqDL 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 516270832  80 IELMLAQPSMIKRPVLdLGDKTL-VGFKPDNYQAAL 114
Cdd:PRK01655  80 IKLISDNPGLLRRPII-IDEKRLqVGYNEDEIRAFL 114
ArsC_ArsC cd03034
Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded ...
 10-104 2.91e-03

Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the detoxification of arsenic, using reducing equivalents derived from glutathione (GSH) via glutaredoxin (GRX). ArsC contains a single catalytic cysteine, within a thioredoxin fold, that forms a covalent thiolate-As(V) intermediate, which is reduced by GRX through a mixed GSH-arsenate intermediate. This family of predominantly bacterial enzymes is unrelated to two other families of arsenate reductases which show similarity to low-molecular-weight acid phosphatases and phosphotyrosyl phosphatases.


Pssm-ID: 239332  Cd Length: 112  Bit Score: 34.49  E-value: 2.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516270832  10 ACDTMKKARTWLDEHQVDYAFHDYKSVGIDRANLekwcnehgwQTVLNRAGTTFRKL----EDAQK------ADLDQVKA 79
Cdd:cd03034    8 RCSKSRNALALLEEAGIEPEIVEYLKTPPTAAEL---------RELLAKLGISPRDLlrtkEAPYKelgladPELSDEEL 78

                         90       100
                 ....*....|....*....|....*
gi 516270832  80 IELMLAQPSMIKRPVLDLGDKTLVG 104
Cdd:cd03034   79 IDAMAAHPILIERPIVVTGDGAVLG 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH