|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
17-437 |
6.09e-97 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 297.50 E-value: 6.09e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 17 LLFQLSIPAVIGMIVIGLYPLMDGIFAGNIIGQTAMTACGVAMPLTFLNSGVSTLLGVGSASVLSRAIGKGDQNTVDKIM 96
Cdd:cd13143 5 LFLKFALPAIIGMLVNGLYNIVDGIFVGHGVGALALAAVNLVFPIIMLLMALGLMIGVGGASLISRRLGAGDREKANRIF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 97 GNLIFWVILFSAIITVGGILLAPHFLDMVGATGEIKAYGIRYLRVIFIGSLFVNFTQSANMVMRGEGLMKKAMMIMGLGA 176
Cdd:cd13143 85 STALLLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGMLIGA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 177 LLNIILDPILMTVMGeYAIEGAALATITAQFVQAVVTLHYFLKKSKVVKIHKI--KSDEEIKKEMFGVGSSAMMMQLLFM 254
Cdd:cd13143 165 VLNIILDPLFIFVLG-LGIAGAALATVIAQLISLLLLLLYFFRGKSLLKLSLLrfKLSLKIIKEILALGFPSFLMQLSSS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 255 IQQTMLYKMAFKYGGDPNGILMAASLRVYAFSFIPLWGMSQGLQPVVGTNFGAKQYDRVRQAMKVFSIGGLILAAVFWIP 334
Cdd:cd13143 244 VVTIVLNLTLLGYGGDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVALIYGLVLFLI 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 335 SLLLSSQILSLFGVEASIITQGVGNFRLFYSVFILYGVMVMSITFFQSIGNGKKAGIIVMLRQLFLFVPAMILLPMVFGV 414
Cdd:cd13143 324 LLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRQGLFLIPLLLILPRLFGL 403
|
410 420
....*....|....*....|...
gi 516239922 415 KAVWFTQPLVDFIMIVVGIFMML 437
Cdd:cd13143 404 DGIWLAFPLAEILTLLLALILLK 426
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
9-435 |
5.78e-75 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 240.82 E-value: 5.78e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 9 LLNKRPIDLLFQLSIPAVIGMIVIGLYPLMDGIFAGNIiGQTAMTACGVAMPLTFLNSGVSTLLGVGSASVLSRAIGKGD 88
Cdd:COG0534 1 LTEGPILKLLLRLALPIILGNLLQSLYGLVDTIFVGRL-GTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 89 QNTVDKIMGNLIFWVILFSAIITVGGILLAPHFLDMVGATGEIKAYGIRYLRVIFIGSLFVNFTQSANMVMRGEGLMKKA 168
Cdd:COG0534 80 REEARRVLGQALLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTP 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 169 MMIMGLGALLNIILDPILMTVmGEYAIEGAALATITAQFVQAVVTLHYFLKKSKVVKIHK--IKSDEEIKKEMFGVGSSA 246
Cdd:COG0534 160 MIIMLIGNVLNIVLDPLLIFG-GGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLrdLRPDRKILKRILRIGLPA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 247 MMMQLLFMIQQTMLYKMAFKYGGDPNGIlMAASLRVYAFSFIPLWGMSQGLQPVVGTNFGAKQYDRVRQAMKVFSIGGLI 326
Cdd:COG0534 239 GLQQLAESLGFLVLNALVARLGTAAVAA-YGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 327 LAAVFWIPSLLLSSQILSLFGVEASIITQGVGNFRLFYSVFILYGVMVMSITFFQSIGNGKKAGIIVMLRQLFLFVPAMI 406
Cdd:COG0534 318 IGLLLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAY 397
|
410 420 430
....*....|....*....|....*....|
gi 516239922 407 LLP-MVFGVKAVWFTQPLVDFIMIVVGIFM 435
Cdd:COG0534 398 LLAfLGLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
18-434 |
7.02e-55 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 188.44 E-value: 7.02e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 18 LFQLSIPAVIGMIVIGLYPLMDGIFAGNIIGQTAMTACGVAMPLTFLNSGVSTLLGVGSASVLSRAIGKGDQNTVDKIMG 97
Cdd:cd13138 5 LLLFALPLLLSNLLQQLYNLVDLLIVGQFLGVAALAAVSNGSPIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAKKAVG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 98 NLIFWVILFSAIITVGGILLAPHFLDMVGATGEIKAYGIRYLRVIFIGSLFVNFTQSANMVMRGEGLMKKAMMIMGLGAL 177
Cdd:cd13138 85 TLLVLFLILGIVLTILGLLFAPPILRLMNTPAEILELAVSYLRICFLGIPFIFGYNAYSAILRGLGDSKTPLYFVIIACV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 178 LNIILDPILMTVMGeYAIEGAALATITAQFVQAVVTLHYFLKKSKVVKIHK--IKSDEEIKKEMFGVGSSAMMMQLLFMI 255
Cdd:cd13138 165 LNIILDLLFIAVFH-MGVAGAALATVIAQAISVLLALYYLRKKKLPFKLSLkdFRFDKEILKEILKIGLPSALQQSLVSI 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 256 QQTMLYKMAFKYGGDPngilMAA---SLRVYAFSFIPLWGMSQGLQPVVGTNFGAKQYDRVRQAMKVFSIGGLILAAVFW 332
Cdd:cd13138 244 SFLIINSIVNSYGVVA----SAAygiANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISLIIGLIII 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 333 IPSLLLSSQILSLFGVEASIITQGVGNFRLFYSVFILYGVMVMSITFFQSIGNGKKAGIIVMLRQLFLFVPAMILLP--M 410
Cdd:cd13138 320 LLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLVRIPLAYLLSrlT 399
|
410 420
....*....|....*....|....
gi 516239922 411 VFGVKAVWFTQPLVDFIMIVVGIF 434
Cdd:cd13138 400 GLGLFGIWLAMPISNILSAIICII 423
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
17-436 |
8.13e-54 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 185.90 E-value: 8.13e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 17 LLFQLSIPAVIGMIVIGLYPLMDGIFAGNIiGQTAMTACGVAMPLTFLNSGVSTLLGVGSASVLSRAIGKGDQNTVDKIM 96
Cdd:cd13144 9 LLLTMSIPAMISMLFQALYNIVDSIFVARL-GENALTAVSLAFPIQNLMIAVAVGTGVGVNALLSRSLGEKDQKEANKAA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 97 GNLIFWVILFSAIITVGGILLAPHFLDMVGATGEIKAYGIRYLRVIFIGSLFVNFTQSANMVMRGEGLMKKAMMIMGLGA 176
Cdd:cd13144 88 NNGLLLALLSYLLFLLLGLFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMIAQLIGA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 177 LLNIILDPILM---TVMGEYAIEGAALATITAQFVQAVVTLHYFLKKSKVVKIHKI--KSDEEIKKEMFGVGSSAMMMQL 251
Cdd:cd13144 168 IINIILDPILIfglFGFPAMGIAGAAIATVIGQILAMFLAFFFLLRKNKDVQPDLRlfRPSLRIIKEIYAVGLPSIIMQA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 252 LFMIQQTMLYKMAFKYGGDPNGILMaASLRVYAFSFIPLWGMSQGLQPVVGTNFGAKQYDRVRQAMKV-FSIGGLILAAV 330
Cdd:cd13144 248 ISSVMVFGLNKILAGFGPTAVAVFG-IYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNKDRIREAIKYaILIAVVIMLAG 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 331 FWIpSLLLSSQILSLFGVEASIITQGVGNFRLFYSVFILYGVMVMSITFFQSIGNGKKAGIIVMLRQLFLFVPAMILLPM 410
Cdd:cd13144 327 GLL-FQLFPDQLLGLFNASEEMLAIGVPALRIISLSFLFAALSIILSGLFQALGRGVYSLIISVARQLVVLLPLAWLLAK 405
|
410 420
....*....|....*....|....*.
gi 516239922 411 VFGVKAVWFTQPLVDFIMIVVGIFMM 436
Cdd:cd13144 406 MFGLNGVWWSFPIAEIVSFLLSLLFL 431
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
21-413 |
9.70e-51 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 177.73 E-value: 9.70e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 21 LSIPAVIGMIVIGLYPLMDGIF-AGniIGQTAMTACGVAMPLTFLNSGVSTLLGVGSASVLSRAIGKGDQNTVDKIMGNL 99
Cdd:cd13147 14 LSIPMIIAMLLQTLYNLVDAIWvAG--LGADALAAIGFVFPLFMIIIGLGNGLGAGASSAISRRIGAKDKEGADNAAVHS 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 100 IFWVILFSAIITVGGILLAPHFLDMVGAtGEIKAYGIRYLRVIFIGSLFVNFTQSANMVMRGEGLMKKAMMIMGLGALLN 179
Cdd:cd13147 92 ILLGLIISIILTIVLLPFLEPILVLMGA-GEVLDLAVDYGRIIFLGSIFLIFNNVAYGILRGEGDTKRAMYAMVAGSILN 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 180 IILDPILMTVMGeYAIEGAALATITAQFVQAVVTLH-YFLKKSKVVKI--HKIKSDEEIKKEMFGVGSSAMMMQLLFMIQ 256
Cdd:cd13147 171 IILDPIFIYTLG-LGIAGAAWATVISMLISSLVLLYwFFVKKDTYVSLslKNFKFDKKIVKDILKVGIPASLEQLIMSVL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 257 QTMLYKMAFKYGGDPNGILMAASLRVYAFSFIPLWGMSQGLQPVVGTNFGAKQYDRVRQA----MKVFSIGGLILAAVFW 332
Cdd:cd13147 250 MIILNLILVIVAGTDGVAVYTAGWRIVSFAIIPLIGIATAVTSVTGAAYGARNYEKLKTAynysIKLGLIIELIIAILIF 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 333 IpsLLLSSQILSLFGVEASIITQGVGNF-RLFYSVFILYGVMVMSITFFQSIGNGKKAGIIVMLRQLFLFVPAMILLPMV 411
Cdd:cd13147 330 I--FAPQIAYLFTYSEESAHLAPEIVAFlRIMCLFLPFVPFGMMSSSMFQGIGKGLTSLIITILRELIFQVLFAYLFAIV 407
|
..
gi 516239922 412 FG 413
Cdd:cd13147 408 LG 409
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
18-431 |
3.74e-46 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 165.38 E-value: 3.74e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 18 LFQLSIPAVIGMIVIGLYPLMDGIFAGNIiGQTAMTACGVAMPLTFLNSGVSTLLGVGSASVLSRAIGKGDQNTVDKIMG 97
Cdd:cd13137 3 IWSLAWPVILENLLQTLVGLVDVFMVGRL-GAEAIAAVGLATQVLWLLLVLNMALGTGTVALVSQSYGAGDYERARRALG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 98 NLIFWVILFSAIITVGGILLAPHFLDMVGATGEIKAYGIRYLRVIFIGSLFVNFTQSANMVMRGEGLMKKAMMIMGLGAL 177
Cdd:cd13137 82 QSLLLALLLSLPLALLGLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIVNV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 178 LNIILDPILMTVMG---EYAIEGAALATITAQFVQAVVTLHYFLKKSKVVKI--HKIKSDEEIKKEMFGVGSSAMMMQLL 252
Cdd:cd13137 162 LNIVLDYVLIFGLWgfpGLGVAGAALATVISRVVGALLLLFLLLRGRLPIKIsfKGFRLDRKIIKKLLRIGLPAGLEQLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 253 FMIQQTMLYKMAFKYGGDPNGiLMAASLRVYAFSFIPLWGMSQGLQPVVGTNFGAKQYDRVRQAMKVFSIGGLILAAVFW 332
Cdd:cd13137 242 RSLGFLVLLAIVASYGTAALA-AYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLFMGLLG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 333 IPSLLLSSQILSLFGVEASIITQGVGNFRLFY-SVFILYGVMVMSITFFQSiGNGKKAGIIVMLRQLFLFVPAMILLPMV 411
Cdd:cd13137 321 LLLFIFAPPLASLFTPDPEVIELGVLYLRIVAlSQPFLAISFVLSGALRGA-GDTRPPLIINLISMWLVRLPLAYLLGFV 399
|
410 420
....*....|....*....|..
gi 516239922 412 F--GVKAVWFTQPLVDFIMIVV 431
Cdd:cd13137 400 LglGLTGIWLAMFVDTIVRAIL 421
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
6-433 |
1.26e-44 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 161.21 E-value: 1.26e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 6 KEQLLNKRPIDLLFQLSIPAVIGMIVIGLYPLMDGIFAGnIIGQTAMTACGVAMPLTFLNSGVSTLLGVGSASVLSRAIG 85
Cdd:cd13142 1 RENILEGSILRTLLKLAWPIIVSNLLQVAYNLADTFWLG-RLGADAVAAPSISWPLIFLFISLGGGLTVAGTALVAQYTG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 86 KGDQNTVDKIMGNLIFWVILFSAIITV-GGILLAPHFLDMVGATGEIKAYGIRYLRVIFIGSLFVNFTQSANMVMRGEGL 164
Cdd:cd13142 80 AGDYDKANKVAGQTFSFVIILSLILAVlGYILSRPLLLLLIGAPEEVYPLALAYLRIIFLGLPFMFIFFVFNSLLRGIGD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 165 MKKAMMIMGLGALLNIILDPILMTVMG---EYAIEGAALATITAQFVQAVVTLHYFLKKSKVVKIHK--IKSDEEIKKEM 239
Cdd:cd13142 160 TKTPMKIMFGSVLLNVILDPLLIFGIGpfpGLGVAGAALATVISRGIAAVIGLYLLFKGRVGLKISLrdLKPDWEWLKKI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 240 FGVG--SSAMM--MQLLFMIQQTMLykmafkyGGDPNGILMAASL--RVYAFSFIPLWGMSQGLQPVVGTNFGAKQYDR- 312
Cdd:cd13142 240 FRIGlpSSIEQsaRALGFTVMTALV-------AGFGTVVVAAYGIgnRIISLVFLPAFGLARATSTMVGQNLGAGQIDRa 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 313 ---VRQAMKVFSIGGLILAAVFWIpsllLSSQILSLFGVEASIITQGVGNFRLFYSVFILYGVMVMSITFFQSIGNGKKA 389
Cdd:cd13142 313 eeiVKKAALLIFLILVIGGVLAFL----FAEPIVRVFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTA 388
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 516239922 390 GIIVMLRQLFLFVPAMILLPMVF--GVKAVWFTQPLVDFIMIVVGI 433
Cdd:cd13142 389 MIISILRLWVIRIPLAYLLAYVLglGVTGIWIAMAISNIVAALIAL 434
|
|
| vmrA |
PRK09575 |
MATE family efflux transporter; |
22-448 |
1.19e-43 |
|
MATE family efflux transporter;
Pssm-ID: 236576 [Multi-domain] Cd Length: 453 Bit Score: 159.00 E-value: 1.19e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 22 SIPAVIGMIVIGLYPLMDGIFAGNIIGQTAMTACGVAMPLTFLNSGVSTLLGVGSASVLSRAIGKGDQNTVDKIMGNLIF 101
Cdd:PRK09575 18 TIPSIAAMLVNGLYQIVDGIFIGHYVGAEGLAGINMAWPVIGIILGIGLMVGMGTGSLLSIKRGEGDLEKAKRILTTGLL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 102 WVILFSAIITVGGILLAPHFLDMVGATGEIKAYGIRYLRVIFIGSLFVNFTQSANMVMRGEGLMKKAMMIMGLGALLNII 181
Cdd:PRK09575 98 LLLLLGPIVSVILFLFADDFLRAQGAEGRTLELALQYIQVLIWGCLFTLGAIALPFLLRNDESPNLATGLMVIGALINIV 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 182 LDPILMTVMGeYAIEGAALATITAQFVQAVVTLHYFL-KKSKV-VKIHKIKSDEEIKKEMFGVGSSAMMMQLLFMIQQTM 259
Cdd:PRK09575 178 LDYLFIGWLD-WGLTGAAIATALAQLVVTVLGLGYFFsSRANIrLTLKELRFNWSLAPKIVLLGSSSFFMYLYGSFVVAL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 260 LYKMAFKYGgdpngilmaASLRVYAFSFIPLW---------GMSQGLQPVVGTNFGAKQYDRVRQAMKVfSIGGLILAAV 330
Cdd:PRK09575 257 HNRLFMEYG---------SALTVGAYAIVGYLmvlyylvaeGIAEGMQPPVSYYFGARQYDNIKKLLKL-AMKVTVLAGI 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 331 FWIPSLLLS-SQILSLFGVE-ASIITQGVGNFRLFYSVFILYGVMVMSITFFQSIGNGKKAGIIV---MLRQL-FLFVpa 404
Cdd:PRK09575 327 AWVLLLNLFpETMIALFNSGdSELIAETIVGIRLHLFAMFLDGFLVLASAYFMAVNQGGKALFISignMLIQLpFLFI-- 404
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 516239922 405 milLPMVFGVKAVWFTQPLVDFIMIVVGIFMMLGELNKMSKEKV 448
Cdd:PRK09575 405 ---LPKWLGVDGVWLAMPLSNIALSLVVAPMLWRDVKKLKKPTQ 445
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
22-433 |
2.27e-43 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 157.49 E-value: 2.27e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 22 SIPAVIGMIVIGLYPLMDGIFAGNIIGqTAMTACGVAMPLTFLNSGVSTLLGVGSASVLSRAIGKGDQNTVDKIMGNLIF 101
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRLLG-DALAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 102 WVILFSAIITVGGILLAPHFLDMVGATGEIKAYGIRYLRVIFIGSLFVNFTQSANMVMRGEGLMKKAMMIMGLGALLNII 181
Cdd:cd12082 80 LAILLGLLLAALLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNIL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 182 LDPILMTVMG--EYAIEGAALATITAQFVQAVVTLHYFLKKSKVVKIH--KIKSDEEIKKEMFGVGSSAMMMQLLFMIQQ 257
Cdd:cd12082 160 LDPLLIFGLGppELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKlsLLKPDLELLRRLLRIGLPSAIQNSLLSLGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 258 TMLYKMAFKYGGDPNGILMAASLRVYAFSFIPLWGMSQGLQPVVGTNFGAKQYDRVRQAMKVFSIGGLILAAVFWIPSLL 337
Cdd:cd12082 240 LIIVAIVAAFGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLILL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 338 LSSQILSLFGVEASIITQGVGNFRLFYSVFILYGVMVMSITFFQSIGNGKKAGIIVMLRQLFLFVP-AMILLPMVFGVKA 416
Cdd:cd12082 320 FPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPlAYVLAYLGLGLYG 399
|
410
....*....|....*..
gi 516239922 417 VWFTQPLVDFIMIVVGI 433
Cdd:cd12082 400 IWLALVISLILAALVLL 416
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
18-434 |
3.31e-39 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 146.29 E-value: 3.31e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 18 LFQLSIPAVIGMIVIGLYPLMDGIFAGNIiGQTAMTACGVAMPLTFLNSGVSTLLGVGSASVLSRAIGKGDQNTVDKIMG 97
Cdd:cd13149 11 LIKLTLPMIFGILAMLIFNLTDTFFVGKL-GTKELAAISFTFPVVLFLNSLTIGLGIGASAVISRAIGAGDRNKAKRLAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 98 NLIFWVILFSAIITVGGILLAPHFLDMVGATGEIKAYGIRYLRVIFIGSLFVNFTQSANMVMRGEGLMKKAMMIMGLGAL 177
Cdd:cd13149 90 DSLILSLLLSVIVSLLGLFTIPPLFSLLGASGEILPLIVEYMAIWYLGLVFLVLPMVGNAIIRATGDTKRPSLVMLGAAL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 178 LNIILDPIL------MTVMGeyaIEGAALATITAQFVQAVVTLHYFLKKSKVV--KIHKIKSDEEIKKEMFGVGSSAMMM 249
Cdd:cd13149 170 VNVILDPILifgfgpIPGMG---IAGAAIATVISRALGLGAALYFLHYHHRLIdfSEPSLKALFRSWKDILSIGIPAALS 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 250 QLLFMIQQTMLYKMAFKYGgdPNGIL-MAASLRVYAFSFIPLWGMSQGLQPVVGTNFGAKQYDRVRQAMKVFSIGGLILA 328
Cdd:cd13149 247 NILTPLSAAFITALVATYG--PAAVAaFGVATRIESFAFIIVMALSSALGPFVGQNWGAGQYERVQEGLKISLKFSLIYG 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 329 AVFWIPSLLLSSQILSLFGVEASIITQGVGNFRLFYSVFILYGVMVMSITFFQSIGNGKKAGIIVMLRQLFLFVPAMILL 408
Cdd:cd13149 325 AILGIVLALFAGWLASLFSAEPEVIELITLYLLIVPIGYGGLGILIITSASFNALGKPLYSLGLNLIRVFLLYIPLAYVG 404
|
410 420
....*....|....*....|....*.
gi 516239922 409 PMVFGVKAVWFTQPLVDFIMIVVGIF 434
Cdd:cd13149 405 SHLLGFAGVFIGALAGNLIAGILAYF 430
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
15-437 |
3.32e-35 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 135.61 E-value: 3.32e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 15 IDLLFQLSIPAVIGMIVIGLYPLMDGIFAGNI--IGQTAMTACGVAMPLTFLNSGVSTLLGVGSASVLSRAIGKGDQNTV 92
Cdd:cd13146 7 SPLLIRLALPILIGQLFQLLYNITDTIWISMIdpSDPALVGGIGLVFPLGMIFLALGNGIQVGVSSLLARAIGAQRAKEL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 93 DKIMGNLIFWVILFSAIITVGGILLAPHFLDMVGATGEIKAYGIRYLRVIFIGSLFVNFTQSANMVMRGEGLMKKAMMIM 172
Cdd:cd13146 87 DQAADSGLALALLAATVIVVLGYIFAEPLLQLLGAKGLLLEYALEYFYYSLPGVPFIMLIGVLMGVLQGEGRTKYMMMAM 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 173 GLGALLNIILDPILMTVMGeYAIEGAALATITAQFVQAVVTLHYFLKKSKVVKIHKIKS--DEEIKKEMFGVGSSAMMMQ 250
Cdd:cd13146 167 LIGTVVNIVLDPILIFVFD-MGVKGAALATVLAQAISLLYLLYVFLIGKSNVTIHIKLSniSSSVIVEILRVGLPQMLLQ 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 251 LLfmIQQTMLYKMAFKYGGDPNgILMAASL--RVYAFSFIPLWGMSQGLQPVVGTNFGAKQYDRVRQAMKVFSIGGLILA 328
Cdd:cd13146 246 LI--SSISFLIYNRIIIDIDPV-AMTAFTLvgRLDQFILIPIFAISSALLTIAGQNWGRGNYDRMLQILMTAVILGIVVV 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 329 AVFWIPSLLLSSQILSLFGVEASIITQGVGNFRLFYSVFILYGVMVMSITFFQSIGNGKKAGIIVMLRQLFLFVPAMILL 408
Cdd:cd13146 323 LVLVLGYVLVAPWLFSLFTTVPEVVAYAVLQVRTMALALPFVAISILVTEFFQAIGKAWPSLLLTLIRHVFLSVPVVYLL 402
|
410 420 430
....*....|....*....|....*....|.
gi 516239922 409 PMVF--GVKAVWFTQPLVDFIMIVVGIFMML 437
Cdd:cd13146 403 AYVFgkGITGVYFGIVSANFFTALLAMFWGL 433
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
10-442 |
1.42e-34 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 133.88 E-value: 1.42e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 10 LNKRPIDLLF-QLSIPAVIGMIVIGLYPLMDGIFAGnIIGQTAMTACGVAMPLTFLNSGVSTLLGVGSASVLSRAIGKGD 88
Cdd:cd13145 2 LTKGPIPKLIrKLAIPASVGFFFNTMFNVVDTFFAG-KISTEALAALSLSFPIFFIIIAIGVGIGTGTTALIGNALGAGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 89 QNTVDKIMGNLIFWVILFSAIITVGGILLAPHFLDMVGATGEIKAYGIRYLRVIFIGSLFVNFTQSANMVMRGEGLMKKA 168
Cdd:cd13145 81 RRKARRYAAQGLSFGIILAILLTVIGLFAAPPLFRLLGAEGDYLDLALEYMDVIFAGSIFFLLNFGLNGILNAQGDTKSY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 169 MMIMGLGALLNIILDPILM---TVMGEYAIEGAALATITAQFVqAVVTLHYFLKKSKVVKIH-------KIKSDEEIKKE 238
Cdd:cd13145 161 RNFLIIGFFLNIILDPLFIfggGGIPAMGVSGIALATIISQFI-GMFYLLYKVRKSGIISGCrlrdfipRLDVYKEILKQ 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 239 MFGVGSSAMMMQLLFMIQQtmlykmafKYGGDPNGILMAA---SLRVYAFSFIPLWGMSQGLQPVVGTNFGAKQYDRVRQ 315
Cdd:cd13145 240 GFPASLNMMTIGLGIFVIT--------YFVGQFGDEAVAAygiALRIEQILLLPTIGLNTAVLSIAGQNFGAKKYDRVRE 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 316 AMKVFSIGGLILAAVFWIPSLLLSSQILSLFGVEASIITQGVGNFRLFYSVFILYGVMVMSITFFQSIGNGKKAGIIVML 395
Cdd:cd13145 312 TYKKALKYGFVIMVVATVFLLFFAEPLMSLFTNDPAVIAIGAGYLRIDALIFYAYVVLFISVSVLQGLKRPIFALWIGLY 391
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 516239922 396 RQLFLFVPAMILLPMVFG--VKAVWFTQPLVDFIMIVVGIFMMLGELNK 442
Cdd:cd13145 392 RQLVGPALVFWLLVNVLGlgVTGIWWGIFTIVWSAAIIALLYTRRVLKK 440
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
18-407 |
2.57e-34 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 133.21 E-value: 2.57e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 18 LFQLSIPAVIGMIVIGLYPLMDGIFAGNIiGQTAMTACGVAMPLTFLNSGVSTLLGVGSASVLSRAIGKGDQNTVDKIMG 97
Cdd:cd13141 13 IISMALPIAIGMIIQTLYFLVDLYFVGQL-GDAALAGVSLAGNVMFFVMALTQVLNVGTAALVSHAVGRKDQGEANAVFN 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 98 NLIFWVILFSAIITVGGILLAPHFLDMVGATGEIKAYGIRYLRViFIGSLFVNFT-QSANMVMRGEGLMKKAMMIMGLGA 176
Cdd:cd13141 92 QSLLLAAVLGLVVLVLGYLFGRLYLETLAADAATVEAATTYLYW-FIPSLALQFIlTVLGAALRGTGIVKPFMVIQILAV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 177 LLNIILDPILMTVMG---EYAIEGAALATITAQFVQAVVTLHYFLKKSKVVKI--HKIKSDEEIKKEMFGVGSSAMMMQL 251
Cdd:cd13141 171 LLNIILAPILITGWGtgrALGVAGAGLASSISVAIAVVLLLYYFLRLEKYLRLdlALWRPDLPTWKRLLKIGLPSGGEFL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 252 LFMIQQTMLYKMAFKYGGDPNGILMAASlRVYAFSFIPLWGMSQGLQPVVGTNFGAKQYDRVRQAMKVFSIGGLILAAVF 331
Cdd:cd13141 251 LTFVYMAVIYWALRPFGAAAQAGFGIGS-RIMQSLFLPAMAIAFAAPAIAGQNFGAGNYDRVRETFRITAILTTALMLVL 329
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 516239922 332 WIPSLLLSSQILSLFGVEASIITQGVGNFRLFYSVFILYGVMVMSITFFQSIGNGKKAGIIVMLRQLFLFVPAMIL 407
Cdd:cd13141 330 TLLCQLVPELLVTPFSDDAAVIAVAATFLRYVSWNFVAAGLVFTCSGMFQALGNTWPSLLSSASRLLTFALPVIWL 405
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
24-333 |
6.32e-32 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 124.66 E-value: 6.32e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 24 PAVIGMIVIGLYPLMDGIFAGNIiGQTAMTACGVAMPLTFLNSGVSTLLGVGSASVLSRAIGKGDQNTVDKIMGNLIFWV 103
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHL-GPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 104 ILFSAIITVGGILLAPHFLDMVGATGEIKAYGIRYLRVIFIGSLFVNFTQSANMVMRGEGLMKKAMMIMGLGALLNIILD 183
Cdd:TIGR00797 80 LLLGLPVLLVGYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 184 PIL-MTVMGEYAIEGAALATITAQFVQAVVTLHYFLKKSKVVKIHKI--KSDEEIKKEMFGVGSSAMMMQLLFMIQQTML 260
Cdd:TIGR00797 160 YILiFGKFGFLGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKWEGllKPDWEVLKRLLKLGLPIAFRVILESLSFALL 239
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 516239922 261 YKMAFKYGGDP---NGILMaaslRVYAFSFIPLWGMSQGLQPVVGTNFGAKQYDRVRQAMKVFSIGGLILAAVFWI 333
Cdd:TIGR00797 240 ALLVARLGSIAlaaHQIAL----NVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAI 311
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
6-433 |
1.55e-31 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 125.42 E-value: 1.55e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 6 KEQLLNKRPID-LLFQLSIPAVIGMIVIGLYPLMDGIFAGNIiGQTAMTACGVAMPLTFLNSGVSTLLGVGSASVLSRAI 84
Cdd:cd13139 3 KEQDFTSGSLNrAIFLLAIPMVLEMVMESLFAVVDLYFVSRL-GALAIATVGLTESVLTIVYSIAIGLSMAATALVARRI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 85 GKGDQNTVDKIMGNLIFWVILFSAIITVGGILLAPHFLDMVGATGEIKAYGIRYLRVIFIGSLFVNFTQSANMVMRGEGL 164
Cdd:cd13139 82 GEKDPEGAGFAAVQAILLGVALSLILSILGYFFAEDILSLMGASPAVIAEGYGYTRIMFGGNGFIMLLFLINGIFRGAGD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 165 MKKAMMIMGLGALLNIILDPILMTVMG---EYAIEGAALATITAQFVQAVVTLHYFLKKSKVVKIHK--IKSDEEIKKEM 239
Cdd:cd13139 162 AAIAMRSLWLANGLNIILDPLFIFGLGpipAMGVTGAAIATTIGRSIGVLYQLYHLFKGKGRIQIRRrhLKLDWAIIKKI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 240 FGVGSSAMMMQLLFMIQQTMLYKMAFKYGGDP-NGILMAasLRVYAFSFIPLWGMSQGLQPVVGTNFGAKQYDRVRQAMK 318
Cdd:cd13139 242 IKIAVGGILQFLIASSSWIFLVRIIAEFGSTAlAGYTIA--IRIIMFALLPAWGLSNAAATLVGQNLGAGQPDRAEKSVW 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 319 ---VFSIGGLILAAVFWIpslLLSSQILSLFGVEASIITQGVGNFRLFYSVFILYGVMVMSITFFQSIGNGKKAGIIVML 395
Cdd:cd13139 320 ragKYNMVFLGIVSLVFF---LFAEPLVSFFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGDTKTPTLINLV 396
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 516239922 396 RQLFLFVPAMILLPMVF--GVKAVWFTQPLVDFIMIVVGI 433
Cdd:cd13139 397 GFWLFQIPLAYLLARHLnlGPKGVFIAIPIAETVLAIAAI 436
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
18-420 |
4.58e-30 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 121.09 E-value: 4.58e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 18 LFQLSIPaVIGMIVIG-LYPLMDGIFAGNIiGQTAMTACGVAMPLTFLNSGVSTLLGVGSASVLSRAIGKGDQNTVDKIM 96
Cdd:cd13140 7 LLRLALP-IMGTSFIQmAYNLTDMFWVGRL-GSDAVAAVGTAGFFVWLAYALALLSKIGAQVKVSQSIGAKDEKEARKYA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 97 GNLIFWVILFSAIITVGGILLAPHFLDMVGATG-EIKAYGIRYLRVIFIGSLFVNFTQSANMVMRGEGLMKKAMMIMGLG 175
Cdd:cd13140 85 RNALQLNLLLGILYGLLLLLFAKPLIGFFNLGDaEVISLAITYLRIVALGLIFSFLNPVFTGIFNALGDSKTPFIINAIG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 176 ALLNIILDPILMTVMG---EYAIEGAALATITAQFVQAVVTLHYFLKKSKVVKIHKIKSDEEIK--KEMFGVGSSAMMMQ 250
Cdd:cd13140 165 LVLNIILDPLLIFGFGpfpALGVAGAALATVLAQAIVFLLFLYALKKKKGLFLKIRILKRPDRKyiKEILKLGLPVALQS 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 251 LLFMIQQTMLYKMAFKYGGDPNGILMAASlRVYAFSFIPLWGMSQGLQPVVGTNFGAKQYDRVRQ----AMKVFSIGGLI 326
Cdd:cd13140 245 ILFALISMILARIIASFGPVAIAAQKVGS-QIESISWMTAEGFSTALAAFVGQNYGAGKYDRIRKgyktALKIASAIGLF 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 327 LAAVFWIpsllLSSQILSLFGVEASIITQGVGNFR-LFYSVFILyGVMVMSITFFQSIGNGKKAGIIVMLRQLFLFVPAM 405
Cdd:cd13140 324 ATLLLFF----FGEPLFSLFIPDPETIAIGVDYLRiLGFSQLFM-CLEITTTGAFNGLGRTKPPAIISIVFNGLRIPLAL 398
|
410
....*....|....*
gi 516239922 406 ILLPMVFGVKAVWFT 420
Cdd:cd13140 399 LLSPTGLGLNGIWWA 413
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
18-331 |
1.99e-29 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 119.14 E-value: 1.99e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 18 LFQLSIPAVIGMIVIGLYPLMDGIFAGNIiGQTAMTACGVAMPLTFLNSGVSTLLGVGSASVLSRAIGKGDQNTVDKIMG 97
Cdd:cd13134 5 LFALAWPIFIELLLQMLLGTIDTFMLSRY-SDNAVAAVGVANQILFLLILIFSFISTGTSILIAQYLGAKDKKKARQIAG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 98 NLIFWVILFSAIITVGGILLAPHFLDMVGATGEIKAYGIRYLRVIFIGSLFVNFTQSANMVMRGEGLMKKAMMIMGLGAL 177
Cdd:cd13134 84 VALLFNLLLGLVFSLLLLFFGAELLRLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIMNI 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 178 LNIILDPILMTV---MGEYAIEGAALATITAQFVQAVVTLHYFLKKSKVVKIHK--IKSDEEIKKEMFGVGSSAMMMQLL 252
Cdd:cd13134 164 LNIVGNYLLIFGwfgLPKLGVAGVAISTVISRAVGLVLLFILLFRKLKIRFRLKdlRPFPKKLLKKILKIGLPSAGEELS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 253 FMIQQTMLYKMAFKYGGDPngilMAAslRVYA-----FSFIPLWGMSQGLQPVVGTNFGAKQYDRVRQAMKVFSIGGLIL 327
Cdd:cd13134 244 YNLSQTVITAFIARLGTAA----LAA--RTYAsnismFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIGLLV 317
|
....
gi 516239922 328 AAVF 331
Cdd:cd13134 318 SLAV 321
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
18-333 |
3.69e-22 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 98.37 E-value: 3.69e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 18 LFQLSIPAVIGMIVIGLYPLMDGIFAGNIiGQTAMTACGVAMPLTFlnsgVSTLLGVGSASVL----SRAIGKGDQNTVD 93
Cdd:cd13133 7 ILKIALPLVLSMLSQTVMGFTDRAFLGRL-SEVALAASGPAGVLYF----AILMLFFGLSSGVqvfvAQYNGAGRYSRIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 94 KIMGNLIFWVILFSAIITVGGILLAPHFLDMVGATGEIKAYGIRYLRVIFIGSLFVNFTQSANMVMRGEGLMKKAMMIMG 173
Cdd:cd13133 82 RVLWQGLYFSLLLAPLLALLSALAAPLLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 174 LGALLNIILDPIL------MTVMGeyaIEGAALATITAQFVQAVVTLHYFLKKSKVVKIHKIKS---DEEIKKEMFGVGS 244
Cdd:cd13133 162 VMVVVNIVLDYALifgklgFPAMG---IAGAAIATVIAEAVSLLFFLLLLFRRKNRRRFGLRRAwrfDRELLRRILRLGL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 245 SAMMMQLLFMIQQTMLYKMAFKYGGDPNGILMAAsLRVYAFSFIPLWGMSQGLQPVVGTNFGAKQYDRVRQA-MKVFSIG 323
Cdd:cd13133 239 PSGLQFFLDVGAFTVFFLLIGRLGTTELAATNIV-FSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVtRRGLKLA 317
|
330
....*....|...
gi 516239922 324 ---GLILAAVFWI 333
Cdd:cd13133 318 layMLLLGILFLL 330
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
18-333 |
1.39e-21 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 96.48 E-value: 1.39e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 18 LFQLSIPAVIGMIVIGLYPLMDGIFAGNIIGQTAMTACGVAMPLTFLNSGVSTLLGVGSASVLSRAIGKGDQNTVDKIMG 97
Cdd:cd13136 5 ILALALPAILSNITVPLLGLVDTAVVGHLGSAAYLGAVALGTTIFNTLFWLFGFLRMGTTGLVAQALGAGDREEAIALLV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 98 NLIFWVILFSAIITVGGILLAPHFLDMVGATGEIKAYGIRYLRVIFIGSLFVNFTQSANMVMRGEGLMKKAMMIMGLGAL 177
Cdd:cd13136 85 RALLLALAIGLLLILLQSPLLALALLLLGASAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTRTPLILQIVGNV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 178 LNIILDPILMTVMGeYAIEGAALATITAQFVQAVVTLHYFLKKSKVVKIHKIKSDEEIK--KEMFGVGSSAMMMQLLFMI 255
Cdd:cd13136 165 VNIVLDPLFVFGLG-WGVAGAALATVIAQYLGALLGLWLLRRRVRLLGKSLSRRLPSKAalKRLFKLNRDIFIRTLALLA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 256 QQTMLYKMAFKYGGDP---NGILMAAslrVYAFSFIpLWGMSQGLQPVVGTNFGAKQYDRVRQAMK-VFSIG---GLILA 328
Cdd:cd13136 244 AFLFFTALAARLGDVIlaaNQILLQF---WLLSSYF-LDGFAYAAEALVGRALGAGDRKAARRVARrLLQWGlglGVLLA 319
|
....*
gi 516239922 329 AVFWI 333
Cdd:cd13136 320 LLFFL 324
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
24-185 |
3.25e-17 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 78.76 E-value: 3.25e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 24 PAVIGMIVIGLYPLMDGIFAGNIiGQTAMTACGVAMPLTFLNSGVSTLLGVGSASVLSRAIGKGDQNTVDKIMGNLIFWV 103
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHL-GAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 104 ILFSAIITVGGILLAPHFLDMVGATGEIKAYGIRYLRVIFIGSLFVNFTQSANMVMRGEGLMKKAMMIMGLGALLNIILD 183
Cdd:pfam01554 80 LLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159
|
..
gi 516239922 184 PI 185
Cdd:pfam01554 160 YL 161
|
|
| MATE_like_3 |
cd13148 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
7-334 |
1.75e-15 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240553 [Multi-domain] Cd Length: 441 Bit Score: 78.08 E-value: 1.75e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 7 EQLLNKRPIDLLFQLSIPAVIGMIVIGLYPLMDGIFAGNIiGQTAMTACGVAMPLTFLNSGVST-LLGVGSASVLSRAIG 85
Cdd:cd13148 3 RALLTAPILPTLLRLALPNILALLVQTLVGLAETYFVGQL-GTDALAGVALVFPLLMLTQMMSNgAMGGGVSSAIARALG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 86 KGDQNTVDKIMGNLIFWVILFSAIITVGGILLAPHFLDMVGATGEIKAYGIRYLRVIFIGSLFVNFTQSANMVMRGEGLM 165
Cdd:cd13148 82 AGDRERAEALVWHALVIALAGGLVFSLLFLLFGPALYRLLGGRGEALDAALAYSNVLFSGAILIWLVNLLAAALRGTGNM 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 166 KKAMMIMGLGALLNIILDPILMTVMG---EYAIEGAALATITAQFVQAVVTLHYFLKKSKVVKI--HKIKSDEEIKKEMF 240
Cdd:cd13148 162 RVPALVTLVGAVVQIPLSPGLILGWGplpRLGVAGAAVAAVLYYALAALVLLRYLASGRSRLRLrlRALRLERRLFRDIL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 241 GVGSSAMMMQLLFMIQQTMLYKMAFKYGGDP-NGILMAASLRvyaFSFIPL-WGMSQGLQPVVGTNFGAKQYDRVRQ--- 315
Cdd:cd13148 242 RVGLLAALSPLQTNLTVLLLTGLVGRFGTAAlAGYGIGSRLE---FLLIPLvFGLGAAMTAMVGMNIGAGQIARARRiaw 318
|
330 340
....*....|....*....|....*.
gi 516239922 316 --AMKVFSIGGLI--LAAVF---WIP 334
Cdd:cd13148 319 tgALMAAVLAGAIglVLALFpelWLG 344
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
17-214 |
9.47e-11 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 63.04 E-value: 9.47e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 17 LLFQLSIPAVIGMIVIGLYPLMDGIFAGNIIGQTAMTACGVAMPLTFLNSGVSTLLGVGSASVLSRAIGKGDQNTVDKIM 96
Cdd:COG2244 174 LVLKYSLPLLLSGLLGLLLTNLDRLLLGALLGPAAVGIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRRLY 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 97 GNLIFWVILFSAIITVGGILLAPHFLDMVgaTGEIKAYGIRYLRVIFIGSLFVNFTQSANMVMRGEGLMKKAMMIMGLGA 176
Cdd:COG2244 254 RKALRLLLLLGLPLALGLALLAPPLLSLL--FGPEYAEAAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIGA 331
|
170 180 190
....*....|....*....|....*....|....*...
gi 516239922 177 LLNIILDPILMTVMGeyaIEGAALATITAQFVQAVVTL 214
Cdd:COG2244 332 VLNLVLNLLLIPRYG---LVGAAIATLLSYLVLLLLLL 366
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
18-331 |
4.77e-09 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 57.97 E-value: 4.77e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 18 LFQLSIPAVIGMIVIGLYPLMDGIFAGNIiGQTAMTACGVAMpLTFLNSGVSTLLGVGSA--SVLSRAIGKGDQNTVDKI 95
Cdd:cd13132 5 LLRLAAPLVLTSLLQYSLSVVSVVFVGHL-GKLELAAASLAS-SFANVTGFSILLGLASAldTLCGQAFGAKNYKLVGVY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 96 M--GNLIFWVILFSAIITvggILLAPHFLDMVGATGEIKAYGIRYLRvIFIGSLFVN-FTQSANMVMRGEGLMKKAMMIM 172
Cdd:cd13132 83 LqrALVILLLCCVPISLL---WLNTEPILLLLGQDPEIARLAGEYLR-WLIPGLFAYaLFEPLKRYLQAQGIVLPLVYIS 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 173 GLGALLNIILDPILMTVMGeYAIEGAALATITAQFVQAVVTLHYFLKKSKVVKIHKIKSDEEIK--KEMFGVGSSAMMMQ 250
Cdd:cd13132 159 LVALLLNILLNYLLVFVLG-LGFIGAALATSISYWLIVVLLLLYIFFSKGHKATWGGFSREAFRgwGPFLKLAIPSALML 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 251 LLFMIQQTMLYKMAFKYGGDPNGILMAASLRVYAFSFIPLWGMSQGLQPVVGTNFGAKQYDRVRQAMKVFSIGGLILAAV 330
Cdd:cd13132 238 CLEWWAFEILVLLAGLLPGTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVV 317
|
.
gi 516239922 331 F 331
Cdd:cd13132 318 V 318
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
2-223 |
6.21e-09 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 57.86 E-value: 6.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 2 KQDMKEQLLNKRPIDLLFQLSIPAVIGMIVIGLYPLMDGIFAGNIIGQTAMTA----------CGVAMPLTFLNSGVSTL 71
Cdd:cd13124 210 RKSPRSKISTKEILKELLSYAIPITLSSLILPLLQLIDSFTVPRRLQAAGLSEseatalygilTGRAQPLVQLPTVIATA 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 72 LGVGSASVLSRAIGKGDQNTVDKIMGNLIFWVILFSAIITVGGILLAPHFLDMVGATGEikayGIRYLRVIFIGSLFVNF 151
Cdd:cd13124 290 LSTSLVPAISEAYAKGDKKELRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGDSE----GGLILQILAPSILFLSL 365
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 516239922 152 TQSANMVMRGEGLMKKAMMIMGLGALLNIILDPILMTVMGeyaIEGAALATITAQFVQAVVTLHYFLKKSKV 223
Cdd:cd13124 366 QQVTAAILQGLGKVKIPVINLLIGLLVKIVLNYVLIPIFG---IYGAAIATVIGFLVAALLNLRALKKLLGF 434
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
6-219 |
7.48e-09 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 57.55 E-value: 7.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 6 KEQLLNKRPIDLLFQLSIPAVIGMIVIGLYPLMDGIFAGNIIGQTAMTACGVAMPLTFLNSGVSTLLGVGSASVLSRAIG 85
Cdd:cd13128 196 KFFSFDLKLAKELLRFSIPLALSGIFSLIYTRIDTIMLGYFLGDAAVGIYNAAYRIAELLLFIPSAISTALFPRISELYK 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 86 KgDQNTVDKIMGNLIFWVILFSAIITVGGILLAPHFLDMVgaTGEIKAYGIRYLRVIFIGSLFVNFTQSANMVMRGEGLM 165
Cdd:cd13128 276 N-DKDELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLL--FGEEYLPAALVLQILAWGFLFIFLNGIFGSILQAIGKQ 352
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 516239922 166 KKAMMIMGLGALLNIILDPILMTVMGeyaIEGAALATITAQFVqAVVTLHYFLK 219
Cdd:cd13128 353 KLTLKILLIGALLNVILNLLLIPKYG---IIGAAIATLISEFI-IFILLLYLLK 402
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
18-223 |
1.57e-08 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 56.53 E-value: 1.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 18 LFQLSIPAVIGMIVIGLYPLMDGIFAGNIiGQTAMTACGVAMPLTFLNSGVSTLLGVGSASVLSRAIGKGDQNTVDKIMG 97
Cdd:cd13135 3 INHIAIPLILQNLVSQLQMLVDRAFLGRI-SIRYYSAVGNVTTPFNTITGFLGSISIGFTILGSQSVGAKDIKRINDYAI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 98 NLIFWVILFSAIITVGGILLAPHFLDMVGATGEIKAYGIRYLRVIFIGSLFVNFTQSANMVMRGEGLMKKAMMIMGLGAL 177
Cdd:cd13135 82 SSIVYNSIIGVILFLLWLFGARIIFVLFGVDGQILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGGIIKNL 161
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 516239922 178 LNIILDPILM---TVMGEYAIEGAALATITAQFVQAVVTLHYFLKKSKV 223
Cdd:cd13135 162 LNVILDYVLIfgnFGFPRLGIIGAAIATTIANVLNLIILVYLCRKIKKL 210
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
18-218 |
1.20e-06 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 50.40 E-value: 1.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 18 LFQLSIPAVIGMIVIGLYPLMDGIFAGNIIGQTAMTACGVAMPLTFLNSGVSTLLGVGSASVLSRAIGKGDQNTVDKIMG 97
Cdd:cd12082 221 LLRIGLPSAIQNSLLSLGLLIIVAIVAAFGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITW 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 98 NLIFWVILFSAIITVGGILLAPHFLDMVGATGEIKAYGIRYLRVIFIGSLFVNFTQSANMVMRGEGLMKKAMMIMGLGAL 177
Cdd:cd12082 301 VALLIGLLIGAVLGLLILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYW 380
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 516239922 178 LNIILDPILMTVMGeYAIEGAALATITAQFVQAVVTLHYFL 218
Cdd:cd12082 381 VVRLPLAYVLAYLG-LGLYGIWLALVISLILAALVLLLFFR 420
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
18-331 |
1.92e-05 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 46.72 E-value: 1.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 18 LFQLSIPAVIGMIVIGLYPLMDGIFAGNIiGQTAMTACGVA----MPLTFLNSGVSTLLGVgsasVLSRAIGKGDQNTVD 93
Cdd:cd13131 5 LLRLALPILIAQLAQMAMGFVDTVMAGRL-GADDLAAVALGsslwFPVFTFGMGLLLAVTP----LVAQAHGAGDRRRIR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 94 KIMGNLIFWVILFSaIITVGGILLAPHFLDMVGATGEIKAYGIRYLRVIFIGSLFVNFTQSANMVMRGEGLMKKAMMIMG 173
Cdd:cd13131 80 RAVRQGLWLALLLS-LPLMLLLWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 174 LGALLNIILDPILMTVMG---EYAIEGAALATITAQFVQAVVTLHYFLK----KSKVVKIHKIKSDEEIKKEMFGVGsSA 246
Cdd:cd13131 159 LALVLNIPLNYVLIFGKFglpALGGAGAGLATAIVYWLMFLALAFYIRRhkrfRRYRLFARFWRPDWARLKELLRLG-LP 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 247 MMMQLLFmiqQTMLYKMAfkyggdpnGILMA-----------ASLRVYAFSF-IPLwGMSQGLQPVVGTNFGAKQYDRVR 314
Cdd:cd13131 238 IGLTIFF---EVSLFAAV--------ALLMGrlgttvlaahqIALNFASLLFmVPL-GISMAATVRVGFALGAGDPADAR 305
|
330
....*....|....*..
gi 516239922 315 QAMKVFSIGGLILAAVF 331
Cdd:cd13131 306 RAGLVGLGLGVGFAALT 322
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
18-220 |
1.12e-04 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 44.42 E-value: 1.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 18 LFQLSIPAVIGMIVIGL-YPLMDGIFAGniIGQTAMTACGVAMPLTFLNSGVSTLLGVGSASVLSRAIGKGDQNTVDKIM 96
Cdd:cd13137 228 LLRIGLPAGLEQLLRSLgFLVLLAIVAS--YGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYG 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 97 GNLIFWVILFSAIITVGGILLAPHFLDMVGATGEIKAYGIRYLRVIFIGSLFVNFTQSANMVMRGEGLMKKAMMIMGLGA 176
Cdd:cd13137 306 KRALRLGVLFMGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISM 385
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 516239922 177 LLNIILDPILMTVMGEYAIEGAALATITAQFVQAVVTLHYFLKK 220
Cdd:cd13137 386 WLVRLPLAYLLGFVLGLGLTGIWLAMFVDTIVRAILLLYRFRKG 429
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
18-220 |
4.17e-04 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 42.44 E-value: 4.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 18 LFQLSIPAVIGMIVIGLYPLMDGIFAgNIIGQTAMTACGVAMPLTFLNSGVstlLGVGSASV----LSRAIGKGDQNTVD 93
Cdd:cd13123 217 VLKLMLPALLGVSVSQINLLVDTILA-SFLPEGSISALYYADRLYQLPLGI---FGVAIATAllprLSRLAAAGDLDEFR 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 94 KIMGNLIFWVILFSAIITVGGILLAPHFLDMVGATGEIKAYGIRYLRVIFIGSLFVNFTQSANMVM------RGEglMKK 167
Cdd:cd13123 293 RTLSRGLRLVLFLLLPAAVGLIVLAEPIVRLLFERGAFTAEDTLMTASALAAYALGLPAFALVKLLsrafyaLKD--TKT 370
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 516239922 168 AMMIMGLGALLNIILDPILMTVMGeyaIEGAALATITAQFVQAVVTLHYFLKK 220
Cdd:cd13123 371 PVKIAVIAVAVNILLNLLLIKPLG---HVGLALATSLSAWVNALLLLVLLRRR 420
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
276-399 |
6.97e-04 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 40.24 E-value: 6.97e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 276 MAASLRVYAFSFIPLWGMSQGLQPVVGTNFGAKQYDRVRQAMKVFSIGGLILAAVFWIPSLLLSSQILSLFGVEASIITQ 355
Cdd:pfam01554 31 VSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGLLLSLPIALLVLLFSEPILSLFGQDEEVLAL 110
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 516239922 356 GVGNFRLFYSVFILYGVMVMSITFFQSIGNGKKAGIIVMLRQLF 399
Cdd:pfam01554 111 AKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLL 154
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
18-220 |
1.78e-03 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 40.52 E-value: 1.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 18 LFQLSIPAVIGMIVIGLYPLMDGIFAGNIiGQTAMTACGVAMPLTFLNSGVstlLGVGSASV----LSRAIGKGDQNTVD 93
Cdd:COG0728 224 VLKLMLPALLGVSVSQINLLVDTILASFL-PEGSVSALYYADRLYQLPLGL---FGVAIGTAllprLSRAAAAGDLEEFR 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 94 KIMGNLIFWVILFSAIITVGGILLAPHFLDMVGATGEIKAYGIRYLRVIFIGSLFVNFTQSANMVM-RG---EGLMKKAM 169
Cdd:COG0728 300 RTLSRGLRLVLLLTLPAAVGLIVLAEPIVRLLFERGAFTAEDTALTALALAAYALGLPAFALVKVLaRAfyaRQDTRTPV 379
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 516239922 170 MIMGLGALLNIILDPILMTVMGeyaIEGAALATITAQFVQAVVTLHYFLKK 220
Cdd:COG0728 380 RIAVIAVVVNIVLNLLLVPPLG---HAGLALATSLSALVNALLLLVLLRRR 427
|
|
| Polysacc_synt_C |
pfam14667 |
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral ... |
138-223 |
7.47e-03 |
|
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral membrane region of polysaccharide biosynthesis proteins.
Pssm-ID: 434111 [Multi-domain] Cd Length: 141 Bit Score: 36.78 E-value: 7.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516239922 138 YLRVIFIGSLFVNFTQSANMVMRGEGLMKKAMMIMGLGALLNIILDPILMTVMGeyaIEGAALATITAQFVQAVVTLHYF 217
Cdd:pfam14667 1 VLQILALSIIFLSLSTVLTSILQGLGRTKLALIALLIGALVKLILNLLLIPLFG---IVGAAIATVISLLVVALLNLYYL 77
|
....*.
gi 516239922 218 LKKSKV 223
Cdd:pfam14667 78 RRYLGL 83
|
|
| |
