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Conserved domains on  [gi|516025404|ref|WP_017455987|]
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two-component system sensor histidine kinase PmrB [Kosakonia sacchari]

Protein Classification

sensor histidine kinase( domain architecture ID 11484924)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals; such as Escherichia coli sensor protein BasS and Pectobacterium parmentieri sensor histidine kinase PmrB

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
9-354 0e+00

two-component system sensor histidine kinase PmrB;


:

Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 506.43  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404   9 WSMRRRLLLTIGGILVFCQLVSVFWLWHESEEQIQLLVQAAIHNHNNRKHIEHEVREAVASLLVPSLLIIGLALLLCMQA 88
Cdd:PRK10755   2 ISLRRRLLLTIGLILLVFQLISVFWLWHESTEQIQLLVQATLSARNNDEHVMKEIREAVASLLVPSLVMVSLTLLICFQA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404  89 VKTITRPLLELQEELNKRTPNNLQPITLNNSVSEVEAVTSSINELVSRLTLTLDRERLFTADVAHELRTPLAGLRLHLEL 168
Cdd:PRK10755  82 VRWITRPLAELQKELEARTADNLTPIAIHSSTLEIEAVTSALNQLVSRLTSTLDQERLFTADVAHELRTPLAGIRLHLEL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 169 MAKTSGINVDPLVQRLEQMTENIAQLLLLARVGQSFSAGSYQQVMLLQDVVQPIRSELEQMLTARQQMLEIAEPEKDIAV 248
Cdd:PRK10755 162 LEKQHHIDVAPLIARLDQMMHTVEQLLQLARAGQSFSSGHYQTVKLLEDVILPSQDELSEMLEQRQQTLLLPESAADITV 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 249 AGDATLLRLLVRNLVENAHRYSPTGSTITVRIENAAT-PVLAVEDEGPGIDESRSGELSKAFVRMDSRYGGAGLGLSIVS 327
Cdd:PRK10755 242 QGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGgAVLAVEDEGPGIDESKCGELSKAFVRMDSRYGGIGLGLSIVS 321

                        330       340
                 ....*....|....*....|....*..
gi 516025404 328 RIAQLHDAQFFLHNRLTQSGVRAWVKF 354
Cdd:PRK10755 322 RITQLHHGQFFLQNRQERSGTRAWVWL 348
 
Name Accession Description Interval E-value
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
9-354 0e+00

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 506.43  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404   9 WSMRRRLLLTIGGILVFCQLVSVFWLWHESEEQIQLLVQAAIHNHNNRKHIEHEVREAVASLLVPSLLIIGLALLLCMQA 88
Cdd:PRK10755   2 ISLRRRLLLTIGLILLVFQLISVFWLWHESTEQIQLLVQATLSARNNDEHVMKEIREAVASLLVPSLVMVSLTLLICFQA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404  89 VKTITRPLLELQEELNKRTPNNLQPITLNNSVSEVEAVTSSINELVSRLTLTLDRERLFTADVAHELRTPLAGLRLHLEL 168
Cdd:PRK10755  82 VRWITRPLAELQKELEARTADNLTPIAIHSSTLEIEAVTSALNQLVSRLTSTLDQERLFTADVAHELRTPLAGIRLHLEL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 169 MAKTSGINVDPLVQRLEQMTENIAQLLLLARVGQSFSAGSYQQVMLLQDVVQPIRSELEQMLTARQQMLEIAEPEKDIAV 248
Cdd:PRK10755 162 LEKQHHIDVAPLIARLDQMMHTVEQLLQLARAGQSFSSGHYQTVKLLEDVILPSQDELSEMLEQRQQTLLLPESAADITV 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 249 AGDATLLRLLVRNLVENAHRYSPTGSTITVRIENAAT-PVLAVEDEGPGIDESRSGELSKAFVRMDSRYGGAGLGLSIVS 327
Cdd:PRK10755 242 QGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGgAVLAVEDEGPGIDESKCGELSKAFVRMDSRYGGIGLGLSIVS 321

                        330       340
                 ....*....|....*....|....*..
gi 516025404 328 RIAQLHDAQFFLHNRLTQSGVRAWVKF 354
Cdd:PRK10755 322 RITQLHHGQFFLQNRQERSGTRAWVWL 348
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 243-354 2.98e-34

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 122.13  E-value: 2.98e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 243 EKDIAVAGDATLLRLLVRNLVENAHRYSPTGSTITVRIENAATPVLAVEDEGPGIDESRSGELSKAFVRMDSR-YGGAGL 321
Cdd:cd16940    2 AADIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGAVIRVEDNGPGIDEEELEALFERFYRSDGQnYGGSGL 81

                         90       100       110
                 ....*....|....*....|....*....|...
gi 516025404 322 GLSIVSRIAQLHDAQFFLHNRLtQSGVRAWVKF 354
Cdd:cd16940   82 GLSIVKRIVELHGGQIFLGNAQ-GGGLEAWVRL 113
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
147-354 8.22e-33

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 122.32  E-value: 8.22e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 147 FTADVAHELRTPLAGLRLHLELMAKTSGINVDPLVQRLE-------QMTENIAQLLLLARVGQSFSAGSYQQVmLLQDVV 219
Cdd:COG2205   19 FLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEiiresaeRLLRLIEDLLDLSRLESGKLSLELEPV-DLAELL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 220 QPIRSELEQMLTARQQMLEIAEPEKDIAVAGDATLLRLLVRNLVENAHRYSPTGSTITVRIENAATPV-LAVEDEGPGID 298
Cdd:COG2205   98 EEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREGDGVrISVSDNGPGIP 177

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 516025404 299 ESRSGELSKAFVRMDS--RYGGAGLGLSIVSRIAQLHDAQFFLHNRLTQsGVRAWVKF 354
Cdd:COG2205  178 EEELERIFERFYRGDNsrGEGGTGLGLAIVKRIVEAHGGTIWVESEPGG-GTTFTVTL 234
phoR_proteo TIGR02966
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ...
 134-336 3.58e-23

phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]


Pssm-ID: 274368 [Multi-domain]  Cd Length: 333  Bit Score: 98.43  E-value: 3.58e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404  134 VSRLTLTLDRERLFTADVAHELRTPLAGLRLHLELMAktSGINVDPLVQR--LEQMTEN-------IAQLLLLARVGQSF 204
Cdd:TIGR02966 104 VTRLRRLEQMRRDFVANVSHELRTPLTVLRGYLETLA--DGPDEDPEEWNraLEIMLEQsqrmqslVEDLLTLSRLESAA 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404  205 SAGSYQQVMLLQdVVQPIRSELEQMLTARQQMLEIaEPEKDIAVAGDATLLRLLVRNLVENAHRYSPTGSTITVRIENAA 284
Cdd:TIGR02966 182 SPLEDEPVDMPA-LLDHLRDEAEALSQGKNHQITF-EIDGGVDVLGDEDELRSAFSNLVSNAIKYTPEGGTITVRWRRDG 259

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 516025404  285 T-PVLAVEDEGPGIDESRSGELSKAFVRMD---SR-YGGAGLGLSIVSRIAQLHDAQ 336
Cdd:TIGR02966 260 GgAEFSVTDTGIGIAPEHLPRLTERFYRVDksrSRdTGGTGLGLAIVKHVLSRHHAR 316
BaeS_SmeS NF012163
sensor histidine kinase efflux regulator BaeS;
95-333 2.95e-17

sensor histidine kinase efflux regulator BaeS;


Pssm-ID: 411086 [Multi-domain]  Cd Length: 457  Bit Score: 82.57  E-value: 2.95e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404  95 PLLELQEELNKRTPNNLQPITLNNSVSEVEAVTSSINELVSRLTLTLDRERLFTADVAHELRTPLAGLRLHLELMA---- 170
Cdd:NF012163 191 PVKRLVEATHRLAAGDYTTRVTPTSNDELGKLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLAVLRAELEAIQdgir 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 171 KTSGINVDPL---VQRLEQMTENIAQLlllarvGQSFSAG-SYQQVMLlqDVVQPIRSELEQM---LTARQQMLEIAEPE 243
Cdd:NF012163 271 KFTPESLDSLqaeVGTLTKLVDDLHDL------SMSDEGAlAYQKASV--DLVPLLEVEGGAFrerFASAGLELEVSLPD 342

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 244 KdIAVAGDATLLRLLVRNLVENAHRYSPTGSTItvRIENAATP---VLAVEDEGPGIDESRSGELSKAFVRMDSRY---- 316
Cdd:NF012163 343 S-SLVFGDRDRLMQLFNNLLENSLRYTDSGGSL--HISASQRPkevTLTVADSAPGVSDEQLARLFERFYRVEVSRnras 419

                        250
                 ....*....|....*..
gi 516025404 317 GGAGLGLSIVSRIAQLH 333
Cdd:NF012163 420 GGSGLGLAISLNIVQAH 436
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 264-354 1.44e-15

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 72.02  E-value: 1.44e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404  264 ENAHRYSPTGSTITVRIENAATPVLAVEDEGPGIDESRSGELSKAFVRMDSR-YGGAGLGLSIVSRIAQLHDAQFFLHNR 342
Cdd:pfam02518  15 DNALKHAAKAGEITVTLSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRgGGGTGLGLSIVRKLVELLGGTITVESE 94

                          90
                  ....*....|..
gi 516025404  343 LTQsGVRAWVKF 354
Cdd:pfam02518  95 PGG-GTTVTLTL 105
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 264-354 8.14e-14

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 66.90  E-value: 8.14e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404   264 ENAHRYSPTGSTITVRIENAATPV-LAVEDEGPGIDESRSGELSKAFVRMD---SRYGGAGLGLSIVSRIAQLHDAQFFL 339
Cdd:smart00387  15 DNAIKYTPEGGRITVTLERDGDHVeITVEDNGPGIPPEDLEKIFEPFFRTDkrsRKIGGTGLGLSIVKKLVELHGGEISV 94

                           90
                   ....*....|....*
gi 516025404   340 HNRLTQsGVRAWVKF 354
Cdd:smart00387  95 ESEPGG-GTTFTITL 108
MtrAB_MtrB NF040691
MtrAB system histidine kinase MtrB;
124-333 4.45e-10

MtrAB system histidine kinase MtrB;


Pssm-ID: 468655 [Multi-domain]  Cd Length: 507  Bit Score: 60.81  E-value: 4.45e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 124 EAVTSSINEL--VSRLtltldrERLFTADVAHELRTPLAGLRLHLELMAKTSGiNVDPLVQR--------LEQMTENIAQ 193
Cdd:NF040691 255 DSLQRQIRQLeeLSRL------QQRFVSDVSHELRTPLTTIRMAADVIHDSRD-DFDPATARsaellhteLDRFESLLSD 327

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 194 LLLLARvgqsFSAGSYQQVMLLQDVVQPIRSELEQM--LTARQQM-LEIAEPEKDIAVAGDATLLRLLVRNLVENAHRYS 270
Cdd:NF040691 328 LLEISR----FDAGAAELDVEPVDLRPLVRRVVDALrqLAERAGVeLRVDAPGTPVVAEVDPRRVERVLRNLVVNAIEHG 403

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 516025404 271 pTGSTITVRIENAATPV-LAVEDEGPGIDESRSGELSKAFVRMD-SR---YGGAGLGLSIVSRIAQLH 333
Cdd:NF040691 404 -EGKPVVVTVAQDDTAVaVTVRDHGVGLKPGEVALVFDRFWRADpARartTGGTGLGLAIALEDARLH 470
HK_WalK NF033092
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ...
 141-333 7.84e-06

cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.


Pssm-ID: 467964 [Multi-domain]  Cd Length: 594  Bit Score: 47.82  E-value: 7.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 141 LDRER-LFTADVAHELRTPLAGLRLHLElmAKTSGINVDP-LVQRLEQMTEN--------IAQLLLLARvgqsFSAGSYQ 210
Cdd:NF033092 368 IEQERrEFVANVSHELRTPLTTMRSYLE--ALADGAWKDPeLAPRFLGVTQNetermirlVNDLLQLSR----MDSKDYK 441

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 211 Q-------VMLLQDVVQpiRSEleqMLTARQQ---MLEIaePEKDIAVAGDATLLRLLVRNLVENAHRYSPTGSTITVR- 279
Cdd:NF033092 442 LnkewvnfNEFFNYIID--RFE---MILKNKNitfKREF--PKRDLWVEIDTDKITQVLDNIISNAIKYSPEGGTITFRl 514

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 516025404 280 IENAATPVLAVEDEGPGIDESRSGELSKAFVRMD---SR-YGGAGLGLSIVSRIAQLH 333
Cdd:NF033092 515 LETHNRIIISISDQGLGIPKKDLDKIFDRFYRVDkarSRkMGGTGLGLAIAKEVVEAH 572
 
Name Accession Description Interval E-value
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
9-354 0e+00

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 506.43  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404   9 WSMRRRLLLTIGGILVFCQLVSVFWLWHESEEQIQLLVQAAIHNHNNRKHIEHEVREAVASLLVPSLLIIGLALLLCMQA 88
Cdd:PRK10755   2 ISLRRRLLLTIGLILLVFQLISVFWLWHESTEQIQLLVQATLSARNNDEHVMKEIREAVASLLVPSLVMVSLTLLICFQA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404  89 VKTITRPLLELQEELNKRTPNNLQPITLNNSVSEVEAVTSSINELVSRLTLTLDRERLFTADVAHELRTPLAGLRLHLEL 168
Cdd:PRK10755  82 VRWITRPLAELQKELEARTADNLTPIAIHSSTLEIEAVTSALNQLVSRLTSTLDQERLFTADVAHELRTPLAGIRLHLEL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 169 MAKTSGINVDPLVQRLEQMTENIAQLLLLARVGQSFSAGSYQQVMLLQDVVQPIRSELEQMLTARQQMLEIAEPEKDIAV 248
Cdd:PRK10755 162 LEKQHHIDVAPLIARLDQMMHTVEQLLQLARAGQSFSSGHYQTVKLLEDVILPSQDELSEMLEQRQQTLLLPESAADITV 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 249 AGDATLLRLLVRNLVENAHRYSPTGSTITVRIENAAT-PVLAVEDEGPGIDESRSGELSKAFVRMDSRYGGAGLGLSIVS 327
Cdd:PRK10755 242 QGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGgAVLAVEDEGPGIDESKCGELSKAFVRMDSRYGGIGLGLSIVS 321

                        330       340
                 ....*....|....*....|....*..
gi 516025404 328 RIAQLHDAQFFLHNRLTQSGVRAWVKF 354
Cdd:PRK10755 322 RITQLHHGQFFLQNRQERSGTRAWVWL 348
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 243-354 2.98e-34

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 122.13  E-value: 2.98e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 243 EKDIAVAGDATLLRLLVRNLVENAHRYSPTGSTITVRIENAATPVLAVEDEGPGIDESRSGELSKAFVRMDSR-YGGAGL 321
Cdd:cd16940    2 AADIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGAVIRVEDNGPGIDEEELEALFERFYRSDGQnYGGSGL 81

                         90       100       110
                 ....*....|....*....|....*....|...
gi 516025404 322 GLSIVSRIAQLHDAQFFLHNRLtQSGVRAWVKF 354
Cdd:cd16940   82 GLSIVKRIVELHGGQIFLGNAQ-GGGLEAWVRL 113
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
147-354 8.22e-33

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 122.32  E-value: 8.22e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 147 FTADVAHELRTPLAGLRLHLELMAKTSGINVDPLVQRLE-------QMTENIAQLLLLARVGQSFSAGSYQQVmLLQDVV 219
Cdd:COG2205   19 FLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEiiresaeRLLRLIEDLLDLSRLESGKLSLELEPV-DLAELL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 220 QPIRSELEQMLTARQQMLEIAEPEKDIAVAGDATLLRLLVRNLVENAHRYSPTGSTITVRIENAATPV-LAVEDEGPGID 298
Cdd:COG2205   98 EEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREGDGVrISVSDNGPGIP 177

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 516025404 299 ESRSGELSKAFVRMDS--RYGGAGLGLSIVSRIAQLHDAQFFLHNRLTQsGVRAWVKF 354
Cdd:COG2205  178 EEELERIFERFYRGDNsrGEGGTGLGLAIVKRIVEAHGGTIWVESEPGG-GTTFTVTL 234
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
142-354 2.46e-31

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 120.78  E-value: 2.46e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 142 DRERLFTADVAHELRTPLAGLRLHLELMAKTSGINVDPLVQRL----EQMTENIAQLLLLARVGQSFSAGSYQQVMLlQD 217
Cdd:COG0642  108 EAKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQREYLETIlrsaDRLLRLINDLLDLSRLEAGKLELEPEPVDL-AE 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 218 VVQPIRSELEQMLTARQQMLEIAEPEKDIAVAGDATLLRLLVRNLVENAHRYSPTGSTITVRIENAATPV-LAVEDEGPG 296
Cdd:COG0642  187 LLEEVVELFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVrISVEDTGPG 266

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 297 IDESRSGELSKAFVRMDS--RYGGAGLGLSIVSRIAQLHDAQFFLHNRLTQsGVRAWVKF 354
Cdd:COG0642  267 IPPEDLERIFEPFFRTDPsrRGGGTGLGLAIVKRIVELHGGTIEVESEPGK-GTTFTVTL 325
PRK10337 PRK10337
sensor protein QseC; Provisional
 94-342 1.01e-30

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 121.29  E-value: 1.01e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404  94 RPLLELQEELNKRTPNNLQPITLNNSVSEVEAVTSSINELVSRLTLTLDRERLFTADVAHELRTPLAGLRLHLELmAKTS 173
Cdd:PRK10337 187 APLKKLALALRMRDPDSETPLNATGVPSEVRPLVEALNQLFARTHAMMVRERRFTSDAAHELRSPLAALKVQTEV-AQLS 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 174 GInvDPLVQR--LEQMTENIA-------QLLLLARVGQSFSAGSYQQVM---LLQDVVqpirseLEQMLTARQQMLEIA- 240
Cdd:PRK10337 266 DD--DPQARKkaLLQLHAGIDratrlvdQLLTLSRLDSLDNLQDVAEIPledLLQSAV------MDIYHTAQQAGIDVRl 337

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 241 -EPEKDIAVAGDATLLRLLVRNLVENAHRYSPTGSTITVRIENAAtpvLAVEDEGPGIDESRSGELSKAFVRMDSR-YGG 318
Cdd:PRK10337 338 tLNAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNARN---FTVRDNGPGVTPEALARIGERFYRPPGQeATG 414

                        250       260
                 ....*....|....*....|....
gi 516025404 319 AGLGLSIVSRIAQLHDAQFFLHNR 342
Cdd:PRK10337 415 SGLGLSIVRRIAKLHGMNVSFGNA 438
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
1-360 2.61e-28

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 113.88  E-value: 2.61e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404   1 MALFNFRRWSMRRRLLLTIGGILVFCQLVSVFWLWHESEEQIQLLVQAAIHNHNNRKHIEHEVREAVASLLVPSLLIIGL 80
Cdd:COG5002    9 LALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLAL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404  81 ALLLCMQAVKTITRPLLELQEELNKRTPNNLQPITLNNSVSEVEAVTSSINELVSRLTLTLDRERL-------------F 147
Cdd:COG5002   89 LLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDitelerleqmrreF 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 148 TADVAHELRTPLAGLRLHLELMAKTSGINVDPLVQRLEQMTEN-------IAQLLLLARVGQSFSAGSYQQVMLlQDVVQ 220
Cdd:COG5002  169 VANVSHELRTPLTSIRGYLELLLDGAADDPEERREYLEIILEEaerlsrlVNDLLDLSRLESGELKLEKEPVDL-AELLE 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 221 PIRSELEQMLTARQQMLEIAEPEKDIAVAGDATLLRLLVRNLVENAHRYSPTGSTITVRIENAATPV-LAVEDEGPGIDE 299
Cdd:COG5002  248 EVVEELRPLAEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVrISVRDTGIGIPE 327

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 516025404 300 SRSGELSKAFVRMDS----RYGGAGLGLSIVSRIAQLHDAQFFLHNRLTQsGVRAWVKfLPGARQ 360
Cdd:COG5002  328 EDLPRIFERFYRVDKsrsrETGGTGLGLAIVKHIVEAHGGRIWVESEPGK-GTTFTIT-LPLARE 390
phoR_proteo TIGR02966
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ...
 134-336 3.58e-23

phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]


Pssm-ID: 274368 [Multi-domain]  Cd Length: 333  Bit Score: 98.43  E-value: 3.58e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404  134 VSRLTLTLDRERLFTADVAHELRTPLAGLRLHLELMAktSGINVDPLVQR--LEQMTEN-------IAQLLLLARVGQSF 204
Cdd:TIGR02966 104 VTRLRRLEQMRRDFVANVSHELRTPLTVLRGYLETLA--DGPDEDPEEWNraLEIMLEQsqrmqslVEDLLTLSRLESAA 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404  205 SAGSYQQVMLLQdVVQPIRSELEQMLTARQQMLEIaEPEKDIAVAGDATLLRLLVRNLVENAHRYSPTGSTITVRIENAA 284
Cdd:TIGR02966 182 SPLEDEPVDMPA-LLDHLRDEAEALSQGKNHQITF-EIDGGVDVLGDEDELRSAFSNLVSNAIKYTPEGGTITVRWRRDG 259

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 516025404  285 T-PVLAVEDEGPGIDESRSGELSKAFVRMD---SR-YGGAGLGLSIVSRIAQLHDAQ 336
Cdd:TIGR02966 260 GgAEFSVTDTGIGIAPEHLPRLTERFYRVDksrSRdTGGTGLGLAIVKHVLSRHHAR 316
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
 94-333 6.75e-19

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 87.44  E-value: 6.75e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404   94 RPLLELQEELNKRTPNNL-QPITLNNSVSEVEAVTSSINELVSRLTLTLDRERLFTADVAHELRTPLAGLRLHLE--LMA 170
Cdd:TIGR01386 190 EPLRRLSAVAARISPESLdQRLDPSRAPAELRELAQSFNAMLGRLEDAFQRLSQFSADLAHELRTPLTNLLGQTQvaLSQ 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404  171 KTSGINVDPLVQ----RLEQMTENIAQLLLLARVGQSFSAGSYQQVMLLQDVVQPIrsELEQMLtARQQMLEIaEPEKDI 246
Cdd:TIGR01386 270 PRTGEEYREVLEsnleELERLSRMVSDMLFLARADNGQLALERVRLDLAAELAKVA--EYFEPL-AEERGVRI-RVEGEG 345

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404  247 AVAGDATLLRLLVRNLVENAHRYSPTGSTITVRIENAATPV-LAVEDEGPGIDESRSGELSKAFVRMD-SRYG---GAGL 321
Cdd:TIGR01386 346 LVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVrVSVSNPGPGIPPEHLSRLFDRFYRVDpARSNsgeGTGL 425

                         250
                  ....*....|..
gi 516025404  322 GLSIVSRIAQLH 333
Cdd:TIGR01386 426 GLAIVRSIMEAH 437
envZ PRK09467
osmolarity sensor protein; Provisional
 121-356 2.12e-18

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 85.73  E-value: 2.12e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 121 SEVEAVTSSINELVSRLTLTLDRERLFTADVAHELRTPLAGLRLHLELMAK-----TSGINVDplvqrLEQMTENIAQLL 195
Cdd:PRK09467 206 SEVRSVTRAFNQMAAGIKQLEDDRTLLMAGVSHDLRTPLTRIRLATEMMSEedgylAESINKD-----IEECNAIIEQFI 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 196 LLARVGQSFSAGSYQQVMLLQDVVQpirSEleqmlTARQQMLEIAEPEKDIAVAGDATLLRLLVRNLVENAHRYSpTGSt 275
Cdd:PRK09467 281 DYLRTGQEMPMEMADLNALLGEVIA---AE-----SGYEREIETALQPGPIEVPMNPIAIKRALANLVVNAARYG-NGW- 350

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 276 itVRIE---NAATPVLAVEDEGPGIDESRSGELSKAFVRMDSRYG--GAGLGLSIVSRIAQLHDAQFFLHNRlTQSGVRA 350
Cdd:PRK09467 351 --IKVSsgtEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARGssGTGLGLAIVKRIVDQHNGKVELGNS-EEGGLSA 427


                 ....*.
gi 516025404 351 WVkFLP 356
Cdd:PRK09467 428 RA-WLP 432
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 152-350 5.52e-18

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 84.90  E-value: 5.52e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 152 AHELRTPLAGLRLHLELMAKtsginvDPLVQRLEQMTENIA-----------QLLLLARVGQSFSAGSYQQVmLLQDVVQ 220
Cdd:PRK11100 264 THELKSPLAAIRGAAELLQE------DPPPEDRARFTGNILtqsarlqqlidRLLELARLEQRQELEVLEPV-ALAALLE 336

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 221 PIRSELEQMLTARQQMLEIAEPekDIAVAGDATLLRLLVRNLVENAHRYSPTGSTITVRIENAATPV-LAVEDEGPGIDE 299
Cdd:PRK11100 337 ELVEAREAQAAAKGITLRLRPD--DARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVaLSVEDQGPGIPD 414

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 516025404 300 ---SRSGELSKAFVRMDSRYGGAGLGLSIVSRIAQLHDAQFFLHNRlTQSGVRA 350
Cdd:PRK11100 415 yalPRIFERFYSLPRPANGRKSTGLGLAFVREVARLHGGEVTLRNR-PEGGVLA 467
BaeS_SmeS NF012163
sensor histidine kinase efflux regulator BaeS;
95-333 2.95e-17

sensor histidine kinase efflux regulator BaeS;


Pssm-ID: 411086 [Multi-domain]  Cd Length: 457  Bit Score: 82.57  E-value: 2.95e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404  95 PLLELQEELNKRTPNNLQPITLNNSVSEVEAVTSSINELVSRLTLTLDRERLFTADVAHELRTPLAGLRLHLELMA---- 170
Cdd:NF012163 191 PVKRLVEATHRLAAGDYTTRVTPTSNDELGKLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLAVLRAELEAIQdgir 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 171 KTSGINVDPL---VQRLEQMTENIAQLlllarvGQSFSAG-SYQQVMLlqDVVQPIRSELEQM---LTARQQMLEIAEPE 243
Cdd:NF012163 271 KFTPESLDSLqaeVGTLTKLVDDLHDL------SMSDEGAlAYQKASV--DLVPLLEVEGGAFrerFASAGLELEVSLPD 342

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 244 KdIAVAGDATLLRLLVRNLVENAHRYSPTGSTItvRIENAATP---VLAVEDEGPGIDESRSGELSKAFVRMDSRY---- 316
Cdd:NF012163 343 S-SLVFGDRDRLMQLFNNLLENSLRYTDSGGSL--HISASQRPkevTLTVADSAPGVSDEQLARLFERFYRVEVSRnras 419

                        250
                 ....*....|....*..
gi 516025404 317 GGAGLGLSIVSRIAQLH 333
Cdd:NF012163 420 GGSGLGLAISLNIVQAH 436
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
116-333 1.37e-16

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 80.75  E-value: 1.37e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 116 LNNSVSEVEAVTSSINELVSRL-TLTLDRERLFTaDVAHELRTPLAGLRLHLELMAKTSGIN-----VDPLVQRLEQMte 189
Cdd:PRK09470 215 LETGPQEFRQAGASFNQMVTALeRMMTSQQRLLS-DISHELRTPLTRLQLATALLRRRQGESkelerIETEAQRLDSM-- 291

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 190 nIAQLLLLAR-------VGQSFSAGSyqqvmLLQDVVQPIRSELEQMltarQQMLEIAEPEKDIAVAGDATLLRLLVRNL 262
Cdd:PRK09470 292 -INDLLVLSRnqqknhlERETFKANS-----LWSEVLEDAKFEAEQM----GKSLTVSAPPGPWPINGNPNALASALENI 361

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 516025404 263 VENAHRYSptGSTITVRIE-NAATPVLAVEDEGPGIDESRSGELSKAFVRMDS----RYGGAGLGLSIVSRIAQLH 333
Cdd:PRK09470 362 VRNALRYS--HTKIEVAFSvDKDGLTITVDDDGPGVPEEEREQIFRPFYRVDEardrESGGTGLGLAIVENAIQQH 435
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 264-354 1.44e-15

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 72.02  E-value: 1.44e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404  264 ENAHRYSPTGSTITVRIENAATPVLAVEDEGPGIDESRSGELSKAFVRMDSR-YGGAGLGLSIVSRIAQLHDAQFFLHNR 342
Cdd:pfam02518  15 DNALKHAAKAGEITVTLSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRgGGGTGLGLSIVRKLVELLGGTITVESE 94

                          90
                  ....*....|..
gi 516025404  343 LTQsGVRAWVKF 354
Cdd:pfam02518  95 PGG-GTTVTLTL 105
PRK10604 PRK10604
sensor protein RstB; Provisional
 151-333 4.47e-15

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 75.80  E-value: 4.47e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 151 VAHELRTPLAGLRLHLELM-----AKTSGINVDplVQRLEQMTEniaQLLLLARVGQsfsagsyQQVMLlqdvvQPIRSE 225
Cdd:PRK10604 219 IAHELRTPLVRLRYRLEMSdnlsaAESQALNRD--IGQLEALIE---ELLTYARLDR-------PQNEL-----HLSEPD 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 226 LEQMLTARQQMLEIAEPEKDIAV---------AGDATLLRLLVRNLVENAHRYSptGSTITVRIE-NAATPVLAVEDEGP 295
Cdd:PRK10604 282 LPAWLSTHLADIQAVTPEKTVRLdtphqgdygALDMRLMERVLDNLLNNALRYA--HSRVRVSLLlDGNQACLIVEDDGP 359

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 516025404 296 GIDESRSGELSKAFVRMD-SR---YGGAGLGLSIVSRIAQLH 333
Cdd:PRK10604 360 GIPPEERERVFEPFVRLDpSRdraTGGCGLGLAIVHSIALAM 401
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
145-336 2.27e-14

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 73.89  E-value: 2.27e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 145 RLFTADVAHELRTPLAGLRLHLELMaktsgiNVDPLVQRLEQ-----MTEN-------IAQLLLLARVGQSfsagsyqQV 212
Cdd:PRK11006 205 RNFFANVSHELRTPLTVLQGYLEMM------QDQPLEGALREkalhtMREQtqrmeglVKQLLTLSKIEAA-------PT 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 213 MLLQDVVQ-PIRSEL----EQMLTARQQMLeIAEPEKDIAVAGDATLLRLLVRNLVENAHRYSPTGSTITVR-IENAATP 286
Cdd:PRK11006 272 IDLNEKVDvPMMLRVlereAQTLSQGKHTI-TFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRwQRVPQGA 350

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 516025404 287 VLAVEDEGPGIDESRSGELSKAFVRMD---SRY-GGAGLGLSIVSRIAQLHDAQ 336
Cdd:PRK11006 351 EFSVEDNGPGIAPEHIPRLTERFYRVDkarSRQtGGSGLGLAIVKHALSHHDSR 404
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 264-354 8.14e-14

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 66.90  E-value: 8.14e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404   264 ENAHRYSPTGSTITVRIENAATPV-LAVEDEGPGIDESRSGELSKAFVRMD---SRYGGAGLGLSIVSRIAQLHDAQFFL 339
Cdd:smart00387  15 DNAIKYTPEGGRITVTLERDGDHVeITVEDNGPGIPPEDLEKIFEPFFRTDkrsRKIGGTGLGLSIVKKLVELHGGEISV 94

                           90
                   ....*....|....*
gi 516025404   340 HNRLTQsGVRAWVKF 354
Cdd:smart00387  95 ESEPGG-GTTFTITL 108
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 137-354 1.36e-13

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 71.53  E-value: 1.36e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 137 LTLTLDRERL-----FTADVAHELRTPLAGLRLHLELMAKTSGINVDPLVQRLEQMTENI-AQLLLLARVGQSFSAGSYQ 210
Cdd:COG5000  189 ITELLRAERLaawgeLARRIAHEIKNPLTPIQLSAERLRRKLADKLEEDREDLERALDTIiRQVDRLKRIVDEFLDFARL 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 211 -----QVMLLQDVVQPIRSELEQMLTARQQMLEIAEPEKDIAVAGDATLLRLLVRNLVENAHRYSPTGSTITVRIENAAT 285
Cdd:COG5000  269 pepqlEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDG 348

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 516025404 286 PV-LAVEDEGPGIDESrsgELSKAFVR-MDSRYGGAGLGLSIVSRIAQLHDAQFFLHNRLtQSGVRAWVKF 354
Cdd:COG5000  349 RVrIEVSDNGPGIPEE---VLERIFEPfFTTKPKGTGLGLAIVKKIVEEHGGTIELESRP-GGGTTFTIRL 415
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 2-333 6.09e-13

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 69.81  E-value: 6.09e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404   2 ALFNFRRWSMRRRLLLTIGGILVFCQLVSVFWLWHESEEQIQLLVQAAIHNHNNRKHIEHEVREAVASLLVPSLLIIGLA 81
Cdd:COG4251  138 EELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAEL 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404  82 LLLCMQAVKTITRPLLELQEELNKRTPNNLqpITLNNSVSEVEAVTSSINELVSRLTLTLDR--ERL--FTADVAHELRT 157
Cdd:COG4251  218 LLSLGGGLGLLLLLLLLLVLLLLLILLLLL--LILVLELLELRLELEELEEELEERTAELERsnEELeqFAYVASHDLRE 295

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 158 PLAGLRLHLELMAKTSGINVDP--------LVQRLEQMTENIAQLLLLARVGQSfsAGSYQQVMLlQDVVQPIRSELEQM 229
Cdd:COG4251  296 PLRKISGFSQLLEEDYGDKLDEegreylerIRDAAERMQALIDDLLAYSRVGRQ--ELEFEPVDL-NELLEEVLEDLEPR 372

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 230 LTARQQMLEIAE-PEkdiaVAGDATLLRLLVRNLVENAHRYSPTGSTITVRI---ENAATPVLAVEDEGPGIDESRSGEL 305
Cdd:COG4251  373 IEERGAEIEVGPlPT----VRGDPTLLRQVFQNLISNAIKYSRPGEPPRIEIgaeREGGEWVFSVRDNGIGIDPEYAEKI 448

                        330       340       350
                 ....*....|....*....|....*....|
gi 516025404 306 SKAFVRMDSR--YGGAGLGLSIVSRIAQLH 333
Cdd:COG4251  449 FEIFQRLHSRdeYEGTGIGLAIVKKIVERH 478
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
88-336 3.69e-12

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 67.10  E-value: 3.69e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404  88 AVKTITRPLLELQEELNKRTPNNLQPITLNNSVS-EVEAVTSSINELVSRLTLTLDRERLFTADVAHELRTPLAGLRLHL 166
Cdd:PRK09835 205 AVHKGHAPIRSVSRQIQNITSKDLDVRLDPQTVPiELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQT 284

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 167 ELM---AKTSGINVDPLVQRLEQ---MTENIAQLLLLARvgqsfsAGSYQ----QVML-LQDVVQPIRSELEQMLTARQQ 235
Cdd:PRK09835 285 EIAlsqSRSQKELEDVLYSNLEEltrMAKMVSDMLFLAQ------ADNNQlipeKKMLdLADEVGKVFDFFEAWAEERGV 358

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 236 MLEIAEpeKDIAVAGDATLLRLLVRNLVENAHRYSPTGSTITVRI-ENAATPVLAVEDEGPGIDESRSGELSKAFVRMD- 313
Cdd:PRK09835 359 ELRFVG--DPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCqEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDp 436

                        250       260
                 ....*....|....*....|....*.
gi 516025404 314 --SRYG-GAGLGLSIVSRIAQLHDAQ 336
Cdd:PRK09835 437 srQRKGeGSGIGLAIVKSIVVAHKGT 462
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 264-342 7.43e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 58.23  E-value: 7.43e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 264 ENAHRYSptGSTITVRIE-NAATPVLAVEDEGPGIDESRSGELSKAFVRMDSRYG--GAGLGLSIVSRIAQLHDAQFFLH 340
Cdd:cd16950   10 DNALRYG--GGWVEVSSDgEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGtsGTGLGLAIVQRISDAHGGSLTLA 87


                 ..
gi 516025404 341 NR 342
Cdd:cd16950   88 NR 89
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 265-334 1.78e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 57.50  E-value: 1.78e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 516025404 265 NAHRYSPTGS-TITVRIENAATPV----LAVEDEGPGIDESRSGELSKAFVRMDS----RYGGAGLGLSIVSRIAQLHD 334
Cdd:cd16922   11 NAIKFTEEGEvTLRVSLEEEEEDGvqlrFSVEDTGIGIPEEQQARLFEPFSQADSsttrKYGGTGLGLAISKKLVELMG 89
marine_sort_HK TIGR03785
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ...
 118-356 2.22e-10

proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.


Pssm-ID: 163497 [Multi-domain]  Cd Length: 703  Bit Score: 62.07  E-value: 2.22e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404  118 NSVSEVEAVTSSINELVSRLTLTLDRERLFTADVAHELRTPLAGLRLHLELMAktSGINVDPLVQRLEQMTENIAQLLLL 197
Cdd:TIGR03785 459 RSRDEIGDLSRSFAQMVARLRQYTHYLENMSSRLSHELRTPVAVVRSSLENLE--LQALEQEKQKYLERAREGTERLSMI 536

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404  198 -------ARVGQSFSAGSYQQVMlLQDVVQPIRSELEQMLTARQQMLEIaePEKDIAVAGDATLLRLLVRNLVENAHRYS 270
Cdd:TIGR03785 537 lnnmseaTRLEQAIQSAEVEDFD-LSEVLSGCMQGYQMTYPPQRFELNI--PETPLVMRGSPELIAQMLDKLVDNAREFS 613

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404  271 PTGSTITVRI-ENAATPVLAVEDEGPGIDESRSGELSKAFVRMdsRYGGA------GLGLSIVSRIAQLHDAQFFLHNRL 343
Cdd:TIGR03785 614 PEDGLIEVGLsQNKSHALLTVSNEGPPLPEDMGEQLFDSMVSV--RDQGAqdqphlGLGLYIVRLIADFHQGRIQAENRQ 691

                         250
                  ....*....|...
gi 516025404  344 TQSGVRAWVKfLP 356
Cdd:TIGR03785 692 QNDGVVFRIS-LP 703
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
131-334 2.52e-10

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 61.57  E-value: 2.52e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 131 NELVSRLTLTLDRERLFTADVAHELRTPLAGLRLHLELMA----KTSGINVDPL---VQRLEQMTENIAQLLLLARVGQS 203
Cdd:PRK10549 227 NQLASTLEKNEQMRRDFMADISHELRTPLAVLRGELEAIQdgvrKFTPESVASLqaeVGTLTKLVDDLHQLSLSDEGALA 306

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 204 FSAGSYQQVMLLQDVVQPIRseleQMLTARQQMLEIAEPEKdIAVAGDATLLRLLVRNLVENAHRYSPTGSTITVRIE-N 282
Cdd:PRK10549 307 YRKTPVDLVPLLEVAGGAFR----ERFASRGLTLQLSLPDS-ATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEqR 381

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 516025404 283 AATPVLAVEDEGPGIDESRSGELSKAFVRMD-SR---YGGAGLGLSIVSRIAQLHD 334
Cdd:PRK10549 382 DKTLRLTFADSAPGVSDEQLQKLFERFYRTEgSRnraSGGSGLGLAICLNIVEAHN 437
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 265-336 3.94e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 56.44  E-value: 3.94e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 516025404 265 NAHRYSPTGSTITVR---IENAATpvLAVEDEGPGIDESRSGELSKAFVRMD----SRYGGAGLGLSIVSRIAQLHDAQ 336
Cdd:cd16952   11 NAVKYTPPSDTITVRwsqEESGAR--LSVEDTGPGIPPEHIPRLTERFYRVDiercRNTGGTGLGLAIVKHVMSRHDAR 87
MtrAB_MtrB NF040691
MtrAB system histidine kinase MtrB;
124-333 4.45e-10

MtrAB system histidine kinase MtrB;


Pssm-ID: 468655 [Multi-domain]  Cd Length: 507  Bit Score: 60.81  E-value: 4.45e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 124 EAVTSSINEL--VSRLtltldrERLFTADVAHELRTPLAGLRLHLELMAKTSGiNVDPLVQR--------LEQMTENIAQ 193
Cdd:NF040691 255 DSLQRQIRQLeeLSRL------QQRFVSDVSHELRTPLTTIRMAADVIHDSRD-DFDPATARsaellhteLDRFESLLSD 327

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 194 LLLLARvgqsFSAGSYQQVMLLQDVVQPIRSELEQM--LTARQQM-LEIAEPEKDIAVAGDATLLRLLVRNLVENAHRYS 270
Cdd:NF040691 328 LLEISR----FDAGAAELDVEPVDLRPLVRRVVDALrqLAERAGVeLRVDAPGTPVVAEVDPRRVERVLRNLVVNAIEHG 403

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 516025404 271 pTGSTITVRIENAATPV-LAVEDEGPGIDESRSGELSKAFVRMD-SR---YGGAGLGLSIVSRIAQLH 333
Cdd:NF040691 404 -EGKPVVVTVAQDDTAVaVTVRDHGVGLKPGEVALVFDRFWRADpARartTGGTGLGLAIALEDARLH 470
PRK10490 PRK10490
sensor protein KdpD; Provisional
 108-342 1.73e-09

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 59.28  E-value: 1.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 108 PNNLQPITLNNSVSEVEAVTSSINELVSRLTLT---------LDRERL---FTADVAHELRTPLAGLR-----LHLELMA 170
Cdd:PRK10490 616 PGNLRQLMIPEQQRLLETFTLLIANALERLTLTaseeqarlaSEREQLrnaLLAALSHDLRTPLTVLFgqaeiLTLDLAS 695

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 171 KTSginvdPLVQRLEQMTENI-------AQLLLLARVgQSFSAGSYQQVMLLQDVVQPIRSELEQMLTARQqmLEIAEPE 243
Cdd:PRK10490 696 EGS-----PHARQASEIRQQVlnttrlvNNLLDMARI-QSGGFNLRKEWLTLEEVVGSALQMLEPGLSGHP--INLSLPE 767

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 244 KDIAVAGDATLLRLLVRNLVENAHRYSPTGSTITVRIENAATPV-LAVEDEGPGIDESRSGELSKAFVRMD--SRYGGAG 320
Cdd:PRK10490 768 PLTLIHVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVEGERLqLDVWDNGPGIPPGQEQLIFDKFARGNkeSAIPGVG 847

                        250       260
                 ....*....|....*....|..
gi 516025404 321 LGLSIVSRIAQLHDAQFFLHNR 342
Cdd:PRK10490 848 LGLAICRAIVEVHGGTIWAENR 869
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 265-333 2.93e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 53.97  E-value: 2.93e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 516025404 265 NAHRYSPTGSTITVRIeNAATPVLAVEDEGPGIDESRSGELSKAFVRMDS----RYGGAGLGLSIVSRIAQLH 333
Cdd:cd16939   11 NALRYAHRTVRIALLV-SGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPsrdrATGGFGLGLAIVHRVALWH 82
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 265-333 6.48e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 53.10  E-value: 6.48e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 516025404 265 NAHRYSPtgSTITVRIENAATPV-LAVEDEGPGIDESRSGELSKAFVRMDSRY----GGAGLGLSIVSRIAQLH 333
Cdd:cd16949   11 NALRYSP--SKILLDISQDGDQWtITITDDGPGVPEDQLEQIFLPFYRVDSARdresGGTGLGLAIAERAIEQH 82
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 264-333 8.87e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 52.85  E-value: 8.87e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 516025404 264 ENAHRYSPTGSTItvRIENAATP---VLAVEDEGPGIDESRSGELSKAFVRMD-SR---YGGAGLGLSIVSRIAQLH 333
Cdd:cd16946   14 ENSLRYTDTGGKL--RIRAAQTPqevRLDVEDSAPGVSDDQLARLFERFYRVEsSRnraSGGSGLGLAICHNIALAH 88
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 147-336 9.85e-09

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 56.52  E-value: 9.85e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 147 FTADVAHELRTPLAGLRLHLELMAKTSGIN----VDPLVQRLEQMTENIAQLLLLARVgqsfSAGSYQQVML---LQDVV 219
Cdd:COG5809  273 LAAGIAHEIRNPLTSLKGFIQLLKDTIDEEqktyLDIMLSELDRIESIISEFLVLAKP----QAIKYEPKDLntlIEEVI 348

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 220 QPIRSelEQMLTARQQMLEIAEPEKDIavAGDATLLRLLVRNLVENAHRYSPTGSTITVRIenAATP----VLAVEDEGP 295
Cdd:COG5809  349 PLLQP--QALLKNVQIELELEDDIPDI--LGDENQLKQVFINLLKNAIEAMPEGGNITIET--KAEDddkvVISVTDEGC 422

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 516025404 296 GIDESRSGELSKAFvrMDSRYGGAGLGLSIVSRIAQLHDAQ 336
Cdd:COG5809  423 GIPEERLKKLGEPF--YTTKEKGTGLGLMVSYKIIEEHGGK 461
HisKA cd00082
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...
 141-199 1.82e-08

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.


Pssm-ID: 119399 [Multi-domain]  Cd Length: 65  Bit Score: 50.67  E-value: 1.82e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 516025404 141 LDRERLFTADVAHELRTPLAGLRLHLELMAKTSGIN------VDPLVQRLEQMTENIAQLLLLAR 199
Cdd:cd00082    1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDeeqreyLERIREEAERLLRLINDLLDLSR 65
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 148-335 2.84e-08

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 55.12  E-value: 2.84e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 148 TADVAHELRTPLAGLRLHLELMAktSGINV-----DPLVQRLEQMTENIAQLLLLARVGQ-SFSAGSYQQvmLLQDVVQP 221
Cdd:COG5805  291 AAGIAHEIRNPLTSIKGFLQLLQ--PGIEDkeeyfDIMLSELDRIESIISEFLALAKPQAvNKEKENINE--LIQDVVTL 366

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 222 IRSEleqmltARQQMLEIA--EPEKDIAVAGDATLLRLLVRNLVENAHRYSPTGSTITVRIENAATPV-LAVEDEGPGID 298
Cdd:COG5805  367 LETE------AILHNIQIRleLLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSViIRVIDEGIGIP 440

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 516025404 299 ESRSGELSKAFVRMDSRygGAGLGLSIVSRIAQLHDA 335
Cdd:COG5805  441 EERLKKLGEPFFTTKEK--GTGLGLMVSYKIIENHNG 475
PRK09303 PRK09303
histidine kinase;
151-333 1.21e-07

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 53.03  E-value: 1.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 151 VAHELRTPLAGLRLHLELMAKTSGINVDPLV------------QRLEQMTENIAQLLLLARvGQSFSAGSYQQVMLLQDV 218
Cdd:PRK09303 158 LAHDLRTPLTAASLALETLELGQIDEDTELKpalieqlqdqarRQLEEIERLITDLLEVGR-TRWEALRFNPQKLDLGSL 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 219 VQPIRSELEQMLTARQQMLEIAEPEKDIAVAGDATLLRLLVRNLVENAHRYSPTGSTITVRIENAATPVLAVE--DEGPG 296
Cdd:PRK09303 237 CQEVILELEKRWLAKSLEIQTDIPSDLPSVYADQERIRQVLLNLLDNAIKYTPEGGTITLSMLHRTTQKVQVSicDTGPG 316

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 516025404 297 IDESrsgELSKAF---VRM--DSRYGGAGLGLSIVSRIAQLH 333
Cdd:PRK09303 317 IPEE---EQERIFedrVRLprDEGTEGYGIGLSVCRRIVRVH 355
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 265-341 1.36e-07

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 49.41  E-value: 1.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 265 NAHRYSPTGSTITVRIENAATP--VLAVEDEGPGIDESRSGELSKAFVRMDS----RYGGAGLGLSIVSRIAQLHDAQFF 338
Cdd:cd16925   15 NAFKFTPDGGRIRCILEKFRLNrfLLTVSDSGPGIPPNLREEIFERFRQGDGsstrAHGGTGLGLSIVKEFVELHGGTVT 94


                 ...
gi 516025404 339 LHN 341
Cdd:cd16925   95 VSD 97
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
151-336 1.82e-07

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 52.16  E-value: 1.82e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 151 VAHELRTPLAGLRLHLELMAKTsgINVDPLVQRLEQMTEN-------IAQLLLLARvgqsFSAGSYQQV---MLLQDVVQ 220
Cdd:COG3852  142 LAHEIRNPLTGIRGAAQLLERE--LPDDELREYTQLIIEEadrlnnlVDRLLSFSR----PRPPEREPVnlhEVLERVLE 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 221 PIRSELEQMLTARQqmleiaEPEKDI-AVAGDATllrllvrnlvE----------NAHRYSPTGSTITVRIENAATP--- 286
Cdd:COG3852  216 LLRAEAPKNIRIVR------DYDPSLpEVLGDPD----------QliqvllnlvrNAAEAMPEGGTITIRTRVERQVtlg 279

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 516025404 287 --------VLAVEDEGPGIDESrsgELSKAFvrmD----SRYGGAGLGLSIVSRIAQLHDAQ 336
Cdd:COG3852  280 glrprlyvRIEVIDNGPGIPEE---ILDRIF---EpfftTKEKGTGLGLAIVQKIVEQHGGT 335
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 264-353 2.11e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 48.61  E-value: 2.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 264 ENAHRYSPTGSTITVRIENAATPV-LAVEDEGPGIDE---SRSGELSKAFVRMDSRYGGAGLGLSIVSRIAQLHDAQFFL 339
Cdd:cd16945   14 DNAIDFSPEGGLIALQLEADTEGIeLLVFDEGSGIPDyalNRVFERFYSLPRPHSGQKSTGLGLAFVQEVAQLHGGRITL 93

                         90
                 ....*....|....
gi 516025404 340 HNRltQSGVRAWVK 353
Cdd:cd16945   94 RNR--PDGVLAFLT 105
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 147-331 3.14e-07

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 52.21  E-value: 3.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 147 FTADVAHELRTPLAGLRLHLELMA-KTSGINVDPLVQRLEQMTENIAQLLLLARVGQSFSAGSyQQVMLLQDVVQPiRSE 225
Cdd:PRK11466 447 FLAAMSHEIRTPLYGILGTAQLLAdNPALNAQRDDLRAITDSGESLLTILNDILDYSAIEAGG-KNVSVSDEPFEP-RPL 524

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 226 LEQMLT-----ARQQMLEIAEPEKDI---AVAGDATLLRLLVRNLVENAHRYSPTGSTITVRIENAATPVLAVEDEGPGI 297
Cdd:PRK11466 525 LESTLQlmsgrVKGRPIRLATDIADDlptALMGDPRRIRQVITNLLSNALRFTDEGSIVLRSRTDGEQWLVEVEDSGCGI 604

                        170       180       190
                 ....*....|....*....|....*....|....
gi 516025404 298 DESRSGELSKAFVRMDSRYGGAGLGLSIVSRIAQ 331
Cdd:PRK11466 605 DPAKLAEIFQPFVQVSGKRGGTGLGLTISSRLAQ 638
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 12-333 4.33e-07

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 51.34  E-value: 4.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404  12 RRRLLLTIGGILVFCQLVSVFWLWHESEEQIQLLVQAAIHNHNNRKHIEHEVREAVASLLVPSLLIIGLALLLCMQAVKT 91
Cdd:COG4191    1 ALRLLLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404  92 ITRPLLELQEELNKRTPNNLQPITLNNSVSEVEAVTSSINELVSRLTLTLDR----ERL-----FTADVAHELRTPLAGL 162
Cdd:COG4191   81 LLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQlvqsEKLaalgeLAAGIAHEINNPLAAI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 163 RLHLELMAK--TSGINVDPLVQRLEQMTEN-------IAQLLLLARVGQSFsagsyQQVMLLQDVVQPIRSELEQMLTAR 233
Cdd:COG4191  161 LGNAELLRRrlEDEPDPEELREALERILEGaeraaeiVRSLRAFSRRDEEE-----REPVDLNELIDEALELLRPRLKAR 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 234 QQMLEIAEPEKDIAVAGDATLLRLLVRNLVENA-----HRYSPtgsTITVRIENAATPV-LAVEDEGPGIDESrsgELSK 307
Cdd:COG4191  236 GIEVELDLPPDLPPVLGDPGQLEQVLLNLLINAidameEGEGG---RITISTRREGDYVvISVRDNGPGIPPE---VLER 309

                        330       340       350
                 ....*....|....*....|....*....|..
gi 516025404 308 AFvrmD------SRYGGAGLGLSIVSRIAQLH 333
Cdd:COG4191  310 IF---EpffttkPVGKGTGLGLSISYGIVEKH 338
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
 145-202 5.12e-07

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 46.44  E-value: 5.12e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 516025404  145 RLFTADVAHELRTPLAGLRLHLELMAKTSGIN-----VDPLVQRLEQMTENIAQLLLLARVGQ 202
Cdd:pfam00512   3 SEFLANLSHELRTPLTAIRGYLELLRDEKLDEeqreyLETILRSAERLLRLINDLLDLSRIEA 65
HisKA smart00388
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...
 145-202 7.44e-07

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.


Pssm-ID: 214644 [Multi-domain]  Cd Length: 66  Bit Score: 46.02  E-value: 7.44e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 516025404   145 RLFTADVAHELRTPLAGLRLHLELMAKTSGIN-----VDPLVQRLEQMTENIAQLLLLARVGQ 202
Cdd:smart00388   3 REFLANLSHELRTPLTAIRGYLELLLDTELSEeqreyLETILREAERLLRLINDLLDLSRIEA 65
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 265-333 9.82e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 46.94  E-value: 9.82e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 516025404 265 NAHRYSPTGSTITVRI---ENAATPVLAVEDEGPGIDESRSGELSKAFVRMDSR--YGGAGLGLSIVSRIAQLH 333
Cdd:cd16921   11 NAIKFRRPRRPPRIEVgaeDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSReeYEGTGVGLAIVRKIIERH 84
PRK15347 PRK15347
two component system sensor kinase;
149-332 6.41e-06

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 48.10  E-value: 6.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 149 ADVAHELRTPLAGLRLHLELMAKTSginVDPLVQRLEQMTENIAqLLLLARVGQ--SFS---AGsyqqvmllQDVVQPIR 223
Cdd:PRK15347 403 TTISHEIRTPLNGVLGALELLQNTP---LTAEQMDLADTARQCT-LSLLAIINNllDFSrieSG--------QMTLSLEE 470

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 224 SELEQMLTarQQMLEIAEP--EKDIAV------------AGDATLLRLLVRNLVENAHRYSPTGStITVRIENAA-TPVL 288
Cdd:PRK15347 471 TALLPLLD--QAMLTIQGPaqSKSLTLrtfvgahvplylHLDSLRLRQILVNLLGNAVKFTETGG-IRLRVKRHEqQLCF 547

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 516025404 289 AVEDEGPGIDESRSGELSKAFVRMDSRYGGAGLGLSIVSRIAQL 332
Cdd:PRK15347 548 TVEDTGCGIDIQQQQQIFTPFYQADTHSQGTGLGLTIASSLAKM 591
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
144-333 7.49e-06

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 47.66  E-value: 7.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 144 ERL-----FTADVAHELRTPLAGLRLHLELMAKTSGINVDP-----LVQRLEQMTENIAQLLLLARVGQSfsagSYQQVm 213
Cdd:PRK11360 385 ERLaalgeLVAGVAHEIRNPLTAIRGYVQIWRQQTSDPPSQeylsvVLREVDRLNKVIDQLLEFSRPRES----QWQPV- 459

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 214 llqDVVQPIRSELEQMLTARQQ---MLEIAEPEKDIAVAGDATLLRLLVRNLVENAHRYSPTGSTITVRIENAA--TPVL 288
Cdd:PRK11360 460 ---SLNALVEEVLQLFQTAGVQarvDFETELDNELPPIWADPELLKQVLLNILINAVQAISARGKIRIRTWQYSdgQVAV 536

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 516025404 289 AVEDEGPGIDESRSGELSKAFvrMDSRYGGAGLGLSIVSRIAQLH 333
Cdd:PRK11360 537 SIEDNGCGIDPELLKKIFDPF--FTTKAKGTGLGLALSQRIINAH 579
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 264-336 7.83e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 44.93  E-value: 7.83e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 516025404 264 ENAHRYSPTGSTITVRiENAATPVLAVEDEGPGIDESRSGELSKAFVRMDSRYGGAGLGLSIVSRIAQLHDAQ 336
Cdd:cd16954   47 DNACKWCLEFVEVTAR-QTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDEQRPGQGLGLAIAKEIVEQYGGE 118
HK_WalK NF033092
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ...
 141-333 7.84e-06

cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.


Pssm-ID: 467964 [Multi-domain]  Cd Length: 594  Bit Score: 47.82  E-value: 7.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 141 LDRER-LFTADVAHELRTPLAGLRLHLElmAKTSGINVDP-LVQRLEQMTEN--------IAQLLLLARvgqsFSAGSYQ 210
Cdd:NF033092 368 IEQERrEFVANVSHELRTPLTTMRSYLE--ALADGAWKDPeLAPRFLGVTQNetermirlVNDLLQLSR----MDSKDYK 441

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 211 Q-------VMLLQDVVQpiRSEleqMLTARQQ---MLEIaePEKDIAVAGDATLLRLLVRNLVENAHRYSPTGSTITVR- 279
Cdd:NF033092 442 LnkewvnfNEFFNYIID--RFE---MILKNKNitfKREF--PKRDLWVEIDTDKITQVLDNIISNAIKYSPEGGTITFRl 514

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 516025404 280 IENAATPVLAVEDEGPGIDESRSGELSKAFVRMD---SR-YGGAGLGLSIVSRIAQLH 333
Cdd:NF033092 515 LETHNRIIISISDQGLGIPKKDLDKIFDRFYRVDkarSRkMGGTGLGLAIAKEVVEAH 572
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 265-340 1.10e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 43.91  E-value: 1.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 265 NAHRYSPTGSTItvRIENAATP---VLAVEDEGPGIDESRSGELSKAFVRMD-SRY-GGAGLGLSIVSRIAQLHDAQFFL 339
Cdd:cd16923   11 NAIKYSPENTRI--YITSFLTDdvvNIMFKNPSSHPLDFKLEKLFERFYRGDnSRNtEGAGLGLSIAKAIIELHGGSASA 88


                 .
gi 516025404 340 H 340
Cdd:cd16923   89 E 89
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 275-333 1.11e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 40.84  E-value: 1.11e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 516025404 275 TITVRIENAATPVLAVEDEGPGIDESRSGELSKAFVrmDSRYGGAGLGLSIVSRIAQLH 333
Cdd:cd16920   27 TIRTSPADDRAVTISVKDTGPGIAEEVAGQLFDPFY--TTKSEGLGMGLSICRSIIEAH 83
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 265-352 1.17e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 40.91  E-value: 1.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 265 NAHRYSPTGSTITVRIENAATPV-LAVEDEGPGIDESRSGELSKAFVRMD-SRYGGA--GLGLSIVSRIAQLHDAQFFLH 340
Cdd:cd16975   15 NACQYAPEGGTVSISIYDEEEYLyFEIWDNGHGFSEQDLKKALELFYRDDtSRRSGGhyGMGLYIAKNLVEKHGGSLIIE 94

                         90
                 ....*....|....*
gi 516025404 341 NrlTQSG---VRAWV 352
Cdd:cd16975   95 N--SQKGgaeVTVKI 107
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 238-342 2.01e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 40.57  E-value: 2.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 238 EIAEPEKDIAVAGDATLLRLLVRNLVENAHRYSPTGSTITVRIENAATPV-LAVEDEGPGIDESrsgELSKAFVRM---- 312
Cdd:cd16947    4 EINIPDRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVyIDIWDKGKGISET---EKDHVFERLytle 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 516025404 313 ---DSRYGGAGLGLSIVSRIAQLHDAQFFLHNR 342
Cdd:cd16947   81 dsrNSAKQGNGLGLTITKRLAESMGGSIYVNSK 113
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 288-333 7.90e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 38.54  E-value: 7.90e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 516025404 288 LAVEDEGPGIDESRSGELSKAFVrmDSRYGGAGLGLSIVSRIAQLH 333
Cdd:cd16918   46 VSVIDNGPGIPPDLQDTIFYPMV--SGRENGTGLGLAIAQNIVSQH 89
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 265-354 1.59e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 37.65  E-value: 1.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 265 NAHRYSPTGSTITVRIENAATPV-LAVEDEGPGIDESrsgELSKAFVRMDSRYGG------AGLGLSIVSRIA-QLHdaq 336
Cdd:cd16948   16 NALKYSKQGGKIEIYSETNEQGVvLSIKDFGIGIPEE---DLPRVFDKGFTGENGrnfqesTGMGLYLVKKLCdKLG--- 89

                         90
                 ....*....|....*...
gi 516025404 337 fflHNRLTQSGVRAWVKF 354
Cdd:cd16948   90 ---HKIDVESEVGEGTTF 104
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 264-333 2.57e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 37.17  E-value: 2.57e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 516025404 264 ENAHRYSP--TGSTITVRIENAATPVLAVEDEGPGIDESRsgeLSKAFVRMDS-RYGGA------GLGLSIVSRIAQLH 333
Cdd:cd16953   10 GNAISFSPpdTGRITVSAMPTGKMVTISVEDEGPGIPQEK---LESIFDRFYTeRPANEafgqhsGLGLSISRQIIEAH 85
glnL PRK11073
nitrogen regulation protein NR(II);
145-325 3.77e-03

nitrogen regulation protein NR(II);


Pssm-ID: 182947 [Multi-domain]  Cd Length: 348  Bit Score: 38.91  E-value: 3.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 145 RLFTADVAHELRTPLAGLRLHLELMAKTSGinvDP------------------LVQRL-------EQMTENIAQllLLAR 199
Cdd:PRK11073 131 RDLVRGLAHEIKNPLGGLRGAAQLLSKALP---DPalteytkviieqadrlrnLVDRLlgpqrpgTHVTESIHK--VAER 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 200 VGQSFSAGSYQQVMLLQDvVQPIRSEL----EQMltaRQQMLEIAEPEKDIAVAGDATLLRLLVRNLVENAH--RYSptg 273
Cdd:PRK11073 206 VVQLVSLELPDNVRLIRD-YDPSLPELahdpDQI---EQVLLNIVRNALQALGPEGGTITLRTRTAFQLTLHgeRYR--- 278

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 516025404 274 stITVRIEnaatpvlaVEDEGPGIDESRSGELskaFVRMDS-RYGGAGLGLSI 325
Cdd:PRK11073 279 --LAARID--------IEDNGPGIPPHLQDTL---FYPMVSgREGGTGLGLSI 318
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 290-345 4.13e-03

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 39.06  E-value: 4.13e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 290 VEDEGPGIDESRSGELSKAFVRMDS----RYGGAGLGLSIVSRIAQLHDAQFFLHNRLTQ 345
Cdd:PRK11107 449 IRDTGIGISERQQSQLFQAFRQADAsisrRHGGTGLGLVITQKLVNEMGGDISFHSQPNR 508
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
111-336 4.34e-03

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 38.85  E-value: 4.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 111 LQPI-TLNNSVSEVE---------AVTSSINELVSRLTLTLDRER-LFT------ADVAHELRTPLAGLRLHLELMAKTS 173
Cdd:PRK10815 216 LRPIeALAKQVRELEegereqldpNPPRELTSLVRNLNRLLKNEReRYTkyrttlTDLTHSLKTPLAVLQSTLRSLRSGK 295

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 174 GINVD---PLVqrLEQMtENIAQLL--LLARVgqSFSAGSyqqvMLLQDVVQPIRSELEQMLTARQQM---------LEI 239
Cdd:PRK10815 296 QMSVEqaePIM--LEQI-SRISQQIgyYLHRA--SMRSEH----NLLSRELHSVAPLLDNLTSALNKVyqrkgvnitLDI 366

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 240 AePEkdIAVAGDATLLRLLVRNLVENAHRYSPTGSTITVRI-ENAATpvLAVEDEGPGIDESRSGELSKAFVRMDSRYGG 318
Cdd:PRK10815 367 S-PE--ITFVGEKNDFMEVMGNVLDNACKYCLEFVEISARQtDEHLH--IVVEDDGPGIPESKRELIFDRGQRADTLRPG 441

                        250
                 ....*....|....*...
gi 516025404 319 AGLGLSIVSRIAQLHDAQ 336
Cdd:PRK10815 442 QGLGLSVAREITEQYEGK 459
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 151-348 9.41e-03

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 38.13  E-value: 9.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 151 VAHELRTPLAGLRLHLeLMAKTSGI--NVDPLVQRLEQMTENIAQLLLLARVGQSFS---AGSYQQVMLLQDVVQPirSE 225
Cdd:COG4192  440 LAHELNQPLNAMSMYL-FSAKKALEqeNYAQLPTSLDKIEGLIERMDKIIKSLRQFSrksDTPLQPVDLRQVIEQA--WE 516

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 516025404 226 LEQMLTARQQMLEIAEPekDIAVAGDATLLRLLVRNLVENAHRYSPTGSTITVRI-ENAATPVLAVEDEGPGIDESRSge 304
Cdd:COG4192  517 LVESRAKPQQITLHIPD--DLMVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLlSNAENLRVAISDNGNGWPLVDK-- 592

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 516025404 305 LSKAFVrmDSRYGGAGLGLSIVSRIAQLHDAQFFLHNRLTQSGV 348
Cdd:COG4192  593 LFTPFT--TTKEVGLGLGLSICRSIMQQFGGDLYLASTLERGAM 634
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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