30S ribosomal protein S12 methylthiotransferase accessory factor YcaO; YcaO acts as a partner ...
4-566
0e+00
30S ribosomal protein S12 methylthiotransferase accessory factor YcaO; YcaO acts as a partner for RimO to achieve the modification of ribosomal protein S12. Homologs of YcaO are involved a wide variety of RiPP (ribosomally translated, post-translationally modified peptide) natural product biosynthesis pathways. Some members of this family have an additional N-terminal OsmC-like domain.
:
Pssm-ID: 468680 [Multi-domain] Cd Length: 571 Bit Score: 873.07 E-value: 0e+00
30S ribosomal protein S12 methylthiotransferase accessory factor YcaO; YcaO acts as a partner ...
4-566
0e+00
30S ribosomal protein S12 methylthiotransferase accessory factor YcaO; YcaO acts as a partner for RimO to achieve the modification of ribosomal protein S12. Homologs of YcaO are involved a wide variety of RiPP (ribosomally translated, post-translationally modified peptide) natural product biosynthesis pathways. Some members of this family have an additional N-terminal OsmC-like domain.
Pssm-ID: 468680 [Multi-domain] Cd Length: 571 Bit Score: 873.07 E-value: 0e+00
YcaO-type kinase domain; This protein family includes YcaO and homologs that can phosphorylate ...
11-399
8.93e-88
YcaO-type kinase domain; This protein family includes YcaO and homologs that can phosphorylate a peptide amide backbone (rather than side chains), as during heterocycle-forming modifications during maturation of the TOMM class (Thiazole/Oxazole-Modified Microcins) of bacteriocins. However, YcaO domain proteins also occur in contexts that do not suggest peptide modification. [Hypothetical proteins, Conserved]
Pssm-ID: 273224 Cd Length: 377 Bit Score: 276.34 E-value: 8.93e-88
YcaO cyclodehydratase, ATP-ad Mg2+-binding; YcaO is an ATP- an Mg2+-binding protein involved ...
59-386
4.49e-64
YcaO cyclodehydratase, ATP-ad Mg2+-binding; YcaO is an ATP- an Mg2+-binding protein involved in the peptidic biosynthesis of azoline. There three motifs involved in the binding are, in UniProtKB:P75838, 71-79: Sx3ExxER, 184-203: Sx6Ex3Qx3ExxER, and 286-290: RxxxE. Three slightly different functional families are represented in this family, proteins involved in TOMM (thiazole/oxazole-modified microcin) biogenesis, non-TOMM proteins such as UniProtKB:P75838, and TfuA-associated non-TOMM proteins involved in trifolitoxin biosynthesis. UniProtKB:P75838 hydrolyses ATP to AMP and pyrophosphate.
Pssm-ID: 426884 Cd Length: 318 Bit Score: 212.53 E-value: 4.49e-64
30S ribosomal protein S12 methylthiotransferase accessory factor YcaO; YcaO acts as a partner ...
4-566
0e+00
30S ribosomal protein S12 methylthiotransferase accessory factor YcaO; YcaO acts as a partner for RimO to achieve the modification of ribosomal protein S12. Homologs of YcaO are involved a wide variety of RiPP (ribosomally translated, post-translationally modified peptide) natural product biosynthesis pathways. Some members of this family have an additional N-terminal OsmC-like domain.
Pssm-ID: 468680 [Multi-domain] Cd Length: 571 Bit Score: 873.07 E-value: 0e+00
YcaO-type kinase domain; This protein family includes YcaO and homologs that can phosphorylate ...
11-399
8.93e-88
YcaO-type kinase domain; This protein family includes YcaO and homologs that can phosphorylate a peptide amide backbone (rather than side chains), as during heterocycle-forming modifications during maturation of the TOMM class (Thiazole/Oxazole-Modified Microcins) of bacteriocins. However, YcaO domain proteins also occur in contexts that do not suggest peptide modification. [Hypothetical proteins, Conserved]
Pssm-ID: 273224 Cd Length: 377 Bit Score: 276.34 E-value: 8.93e-88
YcaO cyclodehydratase, ATP-ad Mg2+-binding; YcaO is an ATP- an Mg2+-binding protein involved ...
59-386
4.49e-64
YcaO cyclodehydratase, ATP-ad Mg2+-binding; YcaO is an ATP- an Mg2+-binding protein involved in the peptidic biosynthesis of azoline. There three motifs involved in the binding are, in UniProtKB:P75838, 71-79: Sx3ExxER, 184-203: Sx6Ex3Qx3ExxER, and 286-290: RxxxE. Three slightly different functional families are represented in this family, proteins involved in TOMM (thiazole/oxazole-modified microcin) biogenesis, non-TOMM proteins such as UniProtKB:P75838, and TfuA-associated non-TOMM proteins involved in trifolitoxin biosynthesis. UniProtKB:P75838 hydrolyses ATP to AMP and pyrophosphate.
Pssm-ID: 426884 Cd Length: 318 Bit Score: 212.53 E-value: 4.49e-64
YcaO cyclodehydratase C-terminal domain; This is the proline-rich C-terminal domain found in ...
406-563
8.27e-17
YcaO cyclodehydratase C-terminal domain; This is the proline-rich C-terminal domain found in ribosomal protein S12 methylthiotransferase accessory factor YcaO. It has been shown to be involved in both C protein recognition and cyclodehydration. The C-terminal domain resembles a tetratricopeptide repeat that mediates dimerization.
Pssm-ID: 465734 Cd Length: 172 Bit Score: 78.33 E-value: 8.27e-17
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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