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Conserved domains on  [gi|515999603|ref|WP_017430186|]
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3-isopropylmalate dehydrogenase [Vreelandella jeotgali]

Protein Classification

3-isopropylmalate dehydrogenase( domain architecture ID 10011514)

3-isopropylmalate dehydrogenase catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate

CATH:  3.40.718.10
EC:  1.1.1.85
Gene Symbol:  leuB
Gene Ontology:  GO:0003862|GO:0046872|GO:0051287
SCOP:  4000791

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 1-358 0e+00

3-isopropylmalate dehydrogenase; Provisional


:

Pssm-ID: 234832  Cd Length: 358  Bit Score: 654.86  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603   1 MTRKVLLLPGDGIGPEITDQAARLLGA-CQTAGLDIDVEKALVGGAAYDAHGEPLPAPTLEKARAADAVLLGAVGGPKWD 79
Cdd:PRK00772   1 MTYKIAVLPGDGIGPEVMAEAVKVLDAvAEKFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603  80 AVeDLSKRPEKGLLGLRKHLGLFGNLRPALLYPQLAEASSLKPELVSGLDIMIVRELTGGIYFGHPRGTEERDGERVGYN 159
Cdd:PRK00772  81 NL-PPDVRPERGLLALRKELGLFANLRPAKLYPGLADASPLKPEIVAGLDILIVRELTGGIYFGEPRGREGLGGEERAFD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 160 TYVYGEAEIERIGRVAFEMAQKRGGKLCSVDKANVLEVTMLWRDVMERLAPEYPDVELSHMYVDNAAMQLVRAPKQFDVV 239
Cdd:PRK00772 160 TMVYTREEIERIARVAFELARKRRKKVTSVDKANVLESSRLWREVVTEVAKEYPDVELSHMYVDNAAMQLVRNPKQFDVI 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 240 VTGNMFGDILSDAAAMLTGSIGMLPSASLNESGQGMFEPCHGSAPDIAGRDLANPLAMMLSVAMMLRYSLGETALAERIE 319
Cdd:PRK00772 240 VTENLFGDILSDEAAMLTGSLGMLPSASLGESGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEEAADAIE 319

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 515999603 320 AAVGRVLDDGLRTADLADDSARAiGTRAMGDAVLEAFAQ 358
Cdd:PRK00772 320 AAVEKVLAQGYRTADIAEGGGKV-STSEMGDAILAALAE 357
 
Name Accession Description Interval E-value
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 1-358 0e+00

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 654.86  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603   1 MTRKVLLLPGDGIGPEITDQAARLLGA-CQTAGLDIDVEKALVGGAAYDAHGEPLPAPTLEKARAADAVLLGAVGGPKWD 79
Cdd:PRK00772   1 MTYKIAVLPGDGIGPEVMAEAVKVLDAvAEKFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603  80 AVeDLSKRPEKGLLGLRKHLGLFGNLRPALLYPQLAEASSLKPELVSGLDIMIVRELTGGIYFGHPRGTEERDGERVGYN 159
Cdd:PRK00772  81 NL-PPDVRPERGLLALRKELGLFANLRPAKLYPGLADASPLKPEIVAGLDILIVRELTGGIYFGEPRGREGLGGEERAFD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 160 TYVYGEAEIERIGRVAFEMAQKRGGKLCSVDKANVLEVTMLWRDVMERLAPEYPDVELSHMYVDNAAMQLVRAPKQFDVV 239
Cdd:PRK00772 160 TMVYTREEIERIARVAFELARKRRKKVTSVDKANVLESSRLWREVVTEVAKEYPDVELSHMYVDNAAMQLVRNPKQFDVI 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 240 VTGNMFGDILSDAAAMLTGSIGMLPSASLNESGQGMFEPCHGSAPDIAGRDLANPLAMMLSVAMMLRYSLGETALAERIE 319
Cdd:PRK00772 240 VTENLFGDILSDEAAMLTGSLGMLPSASLGESGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEEAADAIE 319

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 515999603 320 AAVGRVLDDGLRTADLADDSARAiGTRAMGDAVLEAFAQ 358
Cdd:PRK00772 320 AAVEKVLAQGYRTADIAEGGGKV-STSEMGDAILAALAE 357
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 2-355 0e+00

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 573.88  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603   2 TRKVLLLPGDGIGPEITDQAARLLGA-CQTAGLDIDVEKALVGGAAYDAHGEPLPAPTLEKARAADAVLLGAVGGPKWDA 80
Cdd:COG0473    1 TYKIAVLPGDGIGPEVVAAALKVLEAaAERFGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKWDD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603  81 vedlSKRPEKGLLGLRKHLGLFGNLRPALLYPQLAeaSSLKPELVSGLDIMIVRELTGGIYFGHPRGTEERDGERVGYNT 160
Cdd:COG0473   81 ----GVRPESGLLALRKELDLYANLRPAKLYPGLP--SPLKPEIVEGIDLVIVRENTEGLYFGIGGRIGTGTGEEVAIDT 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 161 YVYGEAEIERIGRVAFEMAQKRGGKLCSVDKANVLEVTM-LWRDVMERLAPEYPDVELSHMYVDNAAMQLVRAPKQFDVV 239
Cdd:COG0473  155 RVYTRKGIERIARYAFELARKRRKKVTSVDKANVLKLTSgLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVI 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 240 VTGNMFGDILSDAAAMLTGSIGMLPSASLNESGQGMFEPCHGSAPDIAGRDLANPLAMMLSVAMMLRYsLGETALAERIE 319
Cdd:COG0473  235 VTENLFGDILSDLAAGLTGSLGLAPSANIGDEGKALFEPVHGSAPDIAGKGIANPIATILSAAMMLRH-LGEEEAADAIE 313

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 515999603 320 AAVGRVLDDGLRTADLADDsaraIGTRAMGDAVLEA 355
Cdd:COG0473  314 AAVEKVLAEGVRTPDLGGK----AGTSEMGDAIIAA 345
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 4-352 0e+00

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 507.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603    4 KVLLLPGDGIGPEITDQAARLLGACQTA-GLDIDVEKALVGGAAYDAHGEPLPAPTLEKARAADAVLLGAVGGPKWDAVE 82
Cdd:TIGR00169   1 KIAVLPGDGIGPEVMAQALKVLKAVAERfGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603   83 DlSKRPEKGLLGLRKHLGLFGNLRPALLYPQLAEASSLKPELVSGLDIMIVRELTGGIYFGHPRGteeRDGERVGYNTYV 162
Cdd:TIGR00169  81 R-DQRPEQGLLKLRKSLDLFANLRPAKVFPGLEDLSPLKEEIAKGVDFVVVRELTGGIYFGEPKG---REGEGEAWDTEV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603  163 YGEAEIERIGRVAFEMAQKRGGKLCSVDKANVLEVTMLWRDVMERLAPEYPDVELSHMYVDNAAMQLVRAPKQFDVVVTG 242
Cdd:TIGR00169 157 YTVPEIERIARVAFEMARKRRKKVTSVDKANVLESSRLWRKTVEEIAKEYPDVELEHQYIDNAAMQLVKSPTQFDVVVTS 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603  243 NMFGDILSDAAAMLTGSIGMLPSASLNESGQGMFEPCHGSAPDIAGRDLANPLAMMLSVAMMLRYSLGETALAERIEAAV 322
Cdd:TIGR00169 237 NLFGDILSDEASVITGSLGMLPSASLGSDGFGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYSFNLEEAADAIEAAV 316

                         330       340       350
                  ....*....|....*....|....*....|
gi 515999603  323 GRVLDDGLRTADLADDSARAIGTRAMGDAV 352
Cdd:TIGR00169 317 KKVLAEGYRTPDLGSSATTAVGTAEMGEEL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
4-352 2.01e-173

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 486.03  E-value: 2.01e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603    4 KVLLLPGDGIGPEITDQAARLLGACQT-AGLDIDVEKALVGGAAYDAHGEPLPAPTLEKARAADAVLLGAVGGPKWDAVE 82
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALEkAPLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWDPAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603   83 dlsKRPEKGLLGLRKHLGLFGNLRPALLYPQLAEASSLKPElVSGLDIMIVRELTGGIYFGHPRGTEERdGERVGYNTYV 162
Cdd:pfam00180  81 ---VRPENGLLALRKELGLFANLRPAKVFPPLGDASPLKNE-VEGVDIVIVRELTGGIYFGIEKGIKGS-GNEVAVDTKL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603  163 YGEAEIERIGRVAFEMAQKRG-GKLCSVDKANVLEVTMLWRDVMERLA-PEYPDVELSHMYVDNAAMQLVRAPKQFDVVV 240
Cdd:pfam00180 156 YSRDEIERIARVAFELARKRGrKKVTSVDKANVLKSSDLWRKIVTEVAkAEYPDVELEHQLVDNAAMQLVKNPSQFDVIV 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603  241 TGNMFGDILSDAAAMLTGSIGMLPSASLNESGQGMFEPCHGSAPDIAGRDLANPLAMMLSVAMMLRYSLGETALAERIEA 320
Cdd:pfam00180 236 TPNLFGDILSDEASMLTGSLGLLPSASLGANGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEDAADKIEA 315

                         330       340       350
                  ....*....|....*....|....*....|..
gi 515999603  321 AVGRVLDDGLRTADLAdDSARAIGTRAMGDAV 352
Cdd:pfam00180 316 AVLKVLESGIRTGDLA-GSATYVSTSEFGEAV 346
AksF2_Meth NF040626
homoisocitrate dehydrogenase;
4-359 1.86e-86

homoisocitrate dehydrogenase;


Pssm-ID: 468598  Cd Length: 332  Bit Score: 264.29  E-value: 1.86e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603   4 KVLLLPGDGIGPEITDQAARLLGACQtagLDIDVEKALVGGAAYDAHGEPLPAPTLEKARAADAVLLGAVggpkwdaved 83
Cdd:NF040626   3 KITVIPGDGIGKEVMEAALYVLDALD---LNFDFIEAEAGRECFKKNGTTIPEETIKIAKKSDATLFGAV---------- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603  84 LSKRPEK-GLLGLRKHLGLFGNLRPALLYPQLaeasslkPELVSGLDIMIVRELTGGIYfghpRGTEERDGERVGYNTYV 162
Cdd:NF040626  70 TSTPGQKsPIITLRKELDLYANLRPIKSYEGI-------NCLFKDLDFLIVRENTEGLY----SGLEEEYTEEKAIAERV 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 163 YGEAEIERIGRVAFEMAQKRG-GKLCSVDKANVLEVT-MLWRDVMERLAPEYPDVELSHMYVDNAAMQLVRAPKQFDVVV 240
Cdd:NF040626 139 ITRKASERICKFAFEYAIKLGrKKVTAVHKANVLKKTdGIFKDTFYKVAKDYPQIETEDYYVDATAMYLITKPQDFDVIV 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 241 TGNMFGDILSDAAAMLTGSIGMLPSASLNESgQGMFEPCHGSAPDIAGRDLANPLAMMLSVAMMLRYsLGETALAERIEA 320
Cdd:NF040626 219 TTNLFGDILSDEAAGLVGGLGLAPSANIGDK-NGLFEPVHGSAPDIAGKNIANPIAMILSASMMLDY-LGETYEANKLEN 296

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 515999603 321 AVGRVLDDG-LRTADLADDSAraigTRAMGDAVLEAFAQQ 359
Cdd:NF040626 297 ALEKVLREGkVVTPDLGGNAK----TMEMANEIKKKIEEL 332
AksF_Meth NF040619
homoisocitrate dehydrogenase;
2-352 1.82e-72

homoisocitrate dehydrogenase;


Pssm-ID: 468591  Cd Length: 332  Bit Score: 228.49  E-value: 1.82e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603   2 TRKVLLLPGDGIGPEITDQAARLLGACQtaglDIDVEKALVGGAAYDAHGEPLPAPTLEKARAADAVLLGAVGGPKWDAV 81
Cdd:NF040619   1 MPKICVIEGDGIGKEVIPETVRVLKELG----DFEFIKGEAGLECFKKYGDAIPEETIEKAKECDAILFGAVTTPKPTEL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603  82 EDLSKRPEkgLLGLRKHLGLFGNLRPALLYPQLaeasslkpELVSGLDIMIVRELTGGIYFGHPRGTEERD---GERVgy 158
Cdd:NF040619  77 KNKNYKSP--ILTLRKELDLYANVRPINNFGDG--------QDVKNIDFVIIRENTEGLYVGREYYDEENEiaiAERI-- 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 159 ntyvYGEAEIERIGRVAFEMAQKRGGKLCS-VDKANVLEVT-MLWRDVMERLAPEY--PDVELSHMYVDNAAMQLVRAPK 234
Cdd:NF040619 145 ----ISKKGSERIIKFAFEYAKKNNRKKVScIHKANVLRVTdGLFLEIFNEIKKKYknFNIEADDYLVDATAMYLIKNPE 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 235 QFDVVVTGNMFGDILSDAAAMLTGSIGMLPSASLNESgQGMFEPCHGSAPDIAGRDLANPLAMMLSVAMMLRYsLGETAL 314
Cdd:NF040619 221 MFDVIVTTNLFGDILSDEASGLIGGLGLAPSANIGDK-KGLFEPVHGSAPDIAGKGIANPIATILSAAMMLDY-LGMKEK 298

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 515999603 315 AERIEAAVGRVLDDGLRTADLADDsaraIGTRAMGDAV 352
Cdd:NF040619 299 GDLIREAVKKCLENGKVTPDLGGN----LKTKEVTDKI 332
 
Name Accession Description Interval E-value
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 1-358 0e+00

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 654.86  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603   1 MTRKVLLLPGDGIGPEITDQAARLLGA-CQTAGLDIDVEKALVGGAAYDAHGEPLPAPTLEKARAADAVLLGAVGGPKWD 79
Cdd:PRK00772   1 MTYKIAVLPGDGIGPEVMAEAVKVLDAvAEKFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603  80 AVeDLSKRPEKGLLGLRKHLGLFGNLRPALLYPQLAEASSLKPELVSGLDIMIVRELTGGIYFGHPRGTEERDGERVGYN 159
Cdd:PRK00772  81 NL-PPDVRPERGLLALRKELGLFANLRPAKLYPGLADASPLKPEIVAGLDILIVRELTGGIYFGEPRGREGLGGEERAFD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 160 TYVYGEAEIERIGRVAFEMAQKRGGKLCSVDKANVLEVTMLWRDVMERLAPEYPDVELSHMYVDNAAMQLVRAPKQFDVV 239
Cdd:PRK00772 160 TMVYTREEIERIARVAFELARKRRKKVTSVDKANVLESSRLWREVVTEVAKEYPDVELSHMYVDNAAMQLVRNPKQFDVI 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 240 VTGNMFGDILSDAAAMLTGSIGMLPSASLNESGQGMFEPCHGSAPDIAGRDLANPLAMMLSVAMMLRYSLGETALAERIE 319
Cdd:PRK00772 240 VTENLFGDILSDEAAMLTGSLGMLPSASLGESGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEEAADAIE 319

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 515999603 320 AAVGRVLDDGLRTADLADDSARAiGTRAMGDAVLEAFAQ 358
Cdd:PRK00772 320 AAVEKVLAQGYRTADIAEGGGKV-STSEMGDAILAALAE 357
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 2-355 0e+00

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 573.88  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603   2 TRKVLLLPGDGIGPEITDQAARLLGA-CQTAGLDIDVEKALVGGAAYDAHGEPLPAPTLEKARAADAVLLGAVGGPKWDA 80
Cdd:COG0473    1 TYKIAVLPGDGIGPEVVAAALKVLEAaAERFGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKWDD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603  81 vedlSKRPEKGLLGLRKHLGLFGNLRPALLYPQLAeaSSLKPELVSGLDIMIVRELTGGIYFGHPRGTEERDGERVGYNT 160
Cdd:COG0473   81 ----GVRPESGLLALRKELDLYANLRPAKLYPGLP--SPLKPEIVEGIDLVIVRENTEGLYFGIGGRIGTGTGEEVAIDT 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 161 YVYGEAEIERIGRVAFEMAQKRGGKLCSVDKANVLEVTM-LWRDVMERLAPEYPDVELSHMYVDNAAMQLVRAPKQFDVV 239
Cdd:COG0473  155 RVYTRKGIERIARYAFELARKRRKKVTSVDKANVLKLTSgLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVI 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 240 VTGNMFGDILSDAAAMLTGSIGMLPSASLNESGQGMFEPCHGSAPDIAGRDLANPLAMMLSVAMMLRYsLGETALAERIE 319
Cdd:COG0473  235 VTENLFGDILSDLAAGLTGSLGLAPSANIGDEGKALFEPVHGSAPDIAGKGIANPIATILSAAMMLRH-LGEEEAADAIE 313

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 515999603 320 AAVGRVLDDGLRTADLADDsaraIGTRAMGDAVLEA 355
Cdd:COG0473  314 AAVEKVLAEGVRTPDLGGK----AGTSEMGDAIIAA 345
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 4-352 0e+00

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 507.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603    4 KVLLLPGDGIGPEITDQAARLLGACQTA-GLDIDVEKALVGGAAYDAHGEPLPAPTLEKARAADAVLLGAVGGPKWDAVE 82
Cdd:TIGR00169   1 KIAVLPGDGIGPEVMAQALKVLKAVAERfGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603   83 DlSKRPEKGLLGLRKHLGLFGNLRPALLYPQLAEASSLKPELVSGLDIMIVRELTGGIYFGHPRGteeRDGERVGYNTYV 162
Cdd:TIGR00169  81 R-DQRPEQGLLKLRKSLDLFANLRPAKVFPGLEDLSPLKEEIAKGVDFVVVRELTGGIYFGEPKG---REGEGEAWDTEV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603  163 YGEAEIERIGRVAFEMAQKRGGKLCSVDKANVLEVTMLWRDVMERLAPEYPDVELSHMYVDNAAMQLVRAPKQFDVVVTG 242
Cdd:TIGR00169 157 YTVPEIERIARVAFEMARKRRKKVTSVDKANVLESSRLWRKTVEEIAKEYPDVELEHQYIDNAAMQLVKSPTQFDVVVTS 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603  243 NMFGDILSDAAAMLTGSIGMLPSASLNESGQGMFEPCHGSAPDIAGRDLANPLAMMLSVAMMLRYSLGETALAERIEAAV 322
Cdd:TIGR00169 237 NLFGDILSDEASVITGSLGMLPSASLGSDGFGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYSFNLEEAADAIEAAV 316

                         330       340       350
                  ....*....|....*....|....*....|
gi 515999603  323 GRVLDDGLRTADLADDSARAIGTRAMGDAV 352
Cdd:TIGR00169 317 KKVLAEGYRTPDLGSSATTAVGTAEMGEEL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
4-352 2.01e-173

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 486.03  E-value: 2.01e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603    4 KVLLLPGDGIGPEITDQAARLLGACQT-AGLDIDVEKALVGGAAYDAHGEPLPAPTLEKARAADAVLLGAVGGPKWDAVE 82
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALEkAPLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWDPAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603   83 dlsKRPEKGLLGLRKHLGLFGNLRPALLYPQLAEASSLKPElVSGLDIMIVRELTGGIYFGHPRGTEERdGERVGYNTYV 162
Cdd:pfam00180  81 ---VRPENGLLALRKELGLFANLRPAKVFPPLGDASPLKNE-VEGVDIVIVRELTGGIYFGIEKGIKGS-GNEVAVDTKL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603  163 YGEAEIERIGRVAFEMAQKRG-GKLCSVDKANVLEVTMLWRDVMERLA-PEYPDVELSHMYVDNAAMQLVRAPKQFDVVV 240
Cdd:pfam00180 156 YSRDEIERIARVAFELARKRGrKKVTSVDKANVLKSSDLWRKIVTEVAkAEYPDVELEHQLVDNAAMQLVKNPSQFDVIV 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603  241 TGNMFGDILSDAAAMLTGSIGMLPSASLNESGQGMFEPCHGSAPDIAGRDLANPLAMMLSVAMMLRYSLGETALAERIEA 320
Cdd:pfam00180 236 TPNLFGDILSDEASMLTGSLGLLPSASLGANGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEDAADKIEA 315

                         330       340       350
                  ....*....|....*....|....*....|..
gi 515999603  321 AVGRVLDDGLRTADLAdDSARAIGTRAMGDAV 352
Cdd:pfam00180 316 AVLKVLESGIRTGDLA-GSATYVSTSEFGEAV 346
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 5-355 2.48e-138

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 399.45  E-value: 2.48e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603   5 VLLLPGDGIGPEITDQAARLL-GACQTAGLDIDVEKALVGGAAYDAHGEPLPAPTLEKARAADAVLLGAVGGPKWDAVED 83
Cdd:PLN02329  49 IALLPGDGIGPEVISVAKNVLqKAGSLEGLEFDFQEMPVGGAALDLVGVPLPEETFTAAKQSDAILLGAIGGYKWDKNEK 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603  84 lSKRPEKGLLGLRKHLGLFGNLRPALLYPQLAEASSLKPELVSGLDIMIVRELTGGIYFGHPRG-TEERDGERVGYNTYV 162
Cdd:PLN02329 129 -HLRPEMALFYLRRDLKVFANLRPATVLPQLVDASTLKKEVAEGVDMMIVRELTGGIYFGEPRGiTINENGEEVGVSTEI 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 163 YGEAEIERIGRVAFEMAQKRGGKLCSVDKANVLEVTMLWRDVMERLAPEYPDVELSHMYVDNAAMQLVRAPKQFDVVVTG 242
Cdd:PLN02329 208 YAAHEIDRIARVAFETARKRRGKLCSVDKANVLDASILWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQFDTIVTN 287

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 243 NMFGDILSDAAAMLTGSIGMLPSASLNESGQGMFEPCHGSAPDIAGRDLANPLAMMLSVAMMLRYSLGETALAERIEAAV 322
Cdd:PLN02329 288 NIFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAAKRIEDAV 367

                        330       340       350
                 ....*....|....*....|....*....|...
gi 515999603 323 GRVLDDGLRTADLADDSARAIGTRAMGDAVLEA 355
Cdd:PLN02329 368 VDALNKGFRTGDIYSPGNKLVGCKEMGEEVLKS 400
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
 1-355 8.40e-87

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 265.64  E-value: 8.40e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603   1 MTRKVLLLPGDGIGPEITDQAARLLGACQTAGLDIDVEKALVGGAAYDAHGEPLPAPTLEKARAADAVLLGAVGGPkwda 80
Cdd:PRK03437   3 KTMKLAVIPGDGIGPEVVAEALKVLDAVAAGGPGVETTEYDLGARRYLRTGETLPDSVLAELRQHDAILLGAIGDP---- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603  81 vedlSKRP---EKG-LLGLRKHLGLFGNLRPALLYPQLAeaSSLK-PELVsglDIMIVRELTGGIYFGH----PRGTEER 151
Cdd:PRK03437  79 ----SVPSgvlERGlLLKLRFALDHYVNLRPSKLYPGVT--SPLAgPGDI---DFVVVREGTEGPYTGNggalRVGTPHE 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 152 DGERVGYNTYvYGeaeIERIGRVAFEMAQKRGGK-LCSVDKANVLEVTM-LWRDVMERLAPEYPDVELSHMYVDNAAMQL 229
Cdd:PRK03437 150 VATEVSVNTA-FG---VERVVRDAFERAQKRPRKhLTLVHKTNVLTFAGdLWQRTVDEVAAEYPDVTVDYQHVDAATIFM 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 230 VRAPKQFDVVVTGNMFGDILSDAAAMLTGSIGMLPSASLNESGQG--MFEPCHGSAPDIAGRDLANPLAMMLSVAMMLRY 307
Cdd:PRK03437 226 VTDPSRFDVIVTDNLFGDIITDLAAAVTGGIGLAASGNINPTGTNpsMFEPVHGSAPDIAGQGIADPTAAILSVALLLDH 305

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 515999603 308 sLGETALAERIEAAVgrvlddglrTADLADDSARAIGTRAMGDAVLEA 355
Cdd:PRK03437 306 -LGEEDAAARIEAAV---------EADLAERGKMGRSTAEVGDRIAAR 343
AksF2_Meth NF040626
homoisocitrate dehydrogenase;
4-359 1.86e-86

homoisocitrate dehydrogenase;


Pssm-ID: 468598  Cd Length: 332  Bit Score: 264.29  E-value: 1.86e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603   4 KVLLLPGDGIGPEITDQAARLLGACQtagLDIDVEKALVGGAAYDAHGEPLPAPTLEKARAADAVLLGAVggpkwdaved 83
Cdd:NF040626   3 KITVIPGDGIGKEVMEAALYVLDALD---LNFDFIEAEAGRECFKKNGTTIPEETIKIAKKSDATLFGAV---------- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603  84 LSKRPEK-GLLGLRKHLGLFGNLRPALLYPQLaeasslkPELVSGLDIMIVRELTGGIYfghpRGTEERDGERVGYNTYV 162
Cdd:NF040626  70 TSTPGQKsPIITLRKELDLYANLRPIKSYEGI-------NCLFKDLDFLIVRENTEGLY----SGLEEEYTEEKAIAERV 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 163 YGEAEIERIGRVAFEMAQKRG-GKLCSVDKANVLEVT-MLWRDVMERLAPEYPDVELSHMYVDNAAMQLVRAPKQFDVVV 240
Cdd:NF040626 139 ITRKASERICKFAFEYAIKLGrKKVTAVHKANVLKKTdGIFKDTFYKVAKDYPQIETEDYYVDATAMYLITKPQDFDVIV 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 241 TGNMFGDILSDAAAMLTGSIGMLPSASLNESgQGMFEPCHGSAPDIAGRDLANPLAMMLSVAMMLRYsLGETALAERIEA 320
Cdd:NF040626 219 TTNLFGDILSDEAAGLVGGLGLAPSANIGDK-NGLFEPVHGSAPDIAGKNIANPIAMILSASMMLDY-LGETYEANKLEN 296

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 515999603 321 AVGRVLDDG-LRTADLADDSAraigTRAMGDAVLEAFAQQ 359
Cdd:NF040626 297 ALEKVLREGkVVTPDLGGNAK----TMEMANEIKKKIEEL 332
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 4-355 2.58e-86

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 263.92  E-value: 2.58e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603   4 KVLLLPGDGIGPEITDQAARLLGAcqtAGLDIDVEKALVGGAAYDAHGEPLPAPTLEKARAADAVLLGAVGGPKWDAVed 83
Cdd:PRK14025   3 KICVIEGDGIGKEVVPAALHVLEA---TGLPFEFVYAEAGDEVFEKTGKALPEETIEAAKEADAVLFGAAGETAADVI-- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603  84 lskrpekglLGLRKHLGLFGNLRPALLYPQLaeasslkPELVSGLDIMIVRELTGGIYfghpRGTEERDGERVGYNTYVY 163
Cdd:PRK14025  78 ---------VKLRRILDTYANVRPVKSYKGV-------KCLYPDIDYVIVRENTEGLY----KGIEAEIADGVTVATRVI 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 164 GEAEIERIGRVAFEMAQKRG-----GKLCSVDKANVLEVTM-LWRDVMERLAPEYPDVELSHMYVDNAAMQLVRAPKQFD 237
Cdd:PRK14025 138 TRKASERIFRFAFEMAKRRKkmgkeGKVTCAHKANVLKKTDgLFKKTFYEVAKEYPDIKAEDYYVDAMNMYIITRPQTFD 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 238 VVVTGNMFGDILSDAAAMLTGSIGMLPSASLNESgQGMFEPCHGSAPDIAGRDLANPLAMMLSVAMMLRYsLGETALAER 317
Cdd:PRK14025 218 VVVTSNLFGDILSDGAAGLVGGLGLAPSANIGDK-YGLFEPVHGSAPDIAGKGIANPTATILTAVLMLRH-LGENEEADK 295

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 515999603 318 IEAAVGRVLDDGLRTADLADDsaraIGTRAMGDAVLEA 355
Cdd:PRK14025 296 VEKALEEVLALGLTTPDLGGN----LSTMEMAEEVAKR 329
LEU3_arch TIGR02088
isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal ...
 5-353 9.93e-85

isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal decarboxylating dehydrogenases which include the leucine biosynthesis enzyme 3-isopropylmalate dehydrogenase (LeuB, LEU3) and the methanogenic cofactor CoB biosynthesis enzyme isohomocitrate dehydrogenase (AksF). Both of these have been characterized in Methanococcus janaschii. Non-methanogenic archaea have only one hit to this model and presumably this is LeuB, although phylogenetic trees cannot establish which gene is which in the methanogens. The AksF gene is capable of acting on isohomocitrate, iso(homo)2-citrate and iso(homo)3-citrate in the successive elongation cycles of coenzyme B (7-mercaptoheptanoyl-threonine phosphate). This family is closely related to both the LeuB genes found in TIGR00169 and the mitochondrial eukaryotic isocitrate dehydratases found in TIGR00175. All of these are included within the broader subfamily model, pfam00180.


Pssm-ID: 273962  Cd Length: 322  Bit Score: 259.70  E-value: 9.93e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603    5 VLLLPGDGIGPEITDQAARLLGAcqtAGLDIDVEKALVGGAAYDAHGEPLPAPTLEKARAADAVLLGAVGGPKWDAVEDL 84
Cdd:TIGR02088   1 VAVIPGDGIGPEVIEAAIRILNK---LGLEIEFIEFEAGDEALKKYGSALPEDTLEEIRKADAILFGAVTTPANPGYKSV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603   85 skrpekgLLGLRKHLGLFGNLRPALLYPQLAEASSLkpelvsGLDIMIVRELTGGIYFGHPRGTEERD-GERVgyntyVY 163
Cdd:TIGR02088  78 -------IVTLRKELDLYANVRPAKSLPGIPDLYPN------GKDIVIVRENTEGLYAGFEFGFSDRAiAIRV-----IT 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603  164 GEAEiERIGRVAFEMAQKRGGKLCSVDKANVLEVT-MLWRDVMERLAPEYpDVELSHMYVDNAAMQLVRAPKQFDVVVTG 242
Cdd:TIGR02088 140 REGS-ERIARFAFNLAKERNRKVTCVHKANVLKGTdGLFREVCREIAKRY-GVEYRDMYVDSAAMNLVKDPWRFDVIVTT 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603  243 NMFGDILSDAAAMLTGSIGMLPSASLNESgQGMFEPCHGSAPDIAGRDLANPLAMMLSVAMMLRYsLGETALAERIEAAV 322
Cdd:TIGR02088 218 NMFGDILSDLASALAGSLGLAPSANIGDR-KALFEPVHGSAPDIAGKGIANPTAAILSVAMMLDY-LGELEKGKLVWEAV 295

                         330       340       350
                  ....*....|....*....|....*....|.
gi 515999603  323 GRVLDDGLRTADLADDSAraigTRAMGDAVL 353
Cdd:TIGR02088 296 EYYIIEGKKTPDLGGTAK----TKEVGDEIA 322
TTC TIGR02089
tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+) ...
 4-355 6.82e-81

tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+)-tartrate as well as a D-malate. These enzymes are closely related to the 3-isopropylmalate and isohomocitrate dehydrogenases found in TIGR00169 and TIGR02088, respectively. [Energy metabolism, Other]


Pssm-ID: 273963  Cd Length: 352  Bit Score: 250.91  E-value: 6.82e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603    4 KVLLLPGDGIGPEITDQAARLLGACQ--TAGLDIDVEKALVGGAAYDAHGEPLPAPTLEKARAADAVLLGAVGGPKwdav 81
Cdd:TIGR02089   5 RIAAIPGDGIGKEVVAAALQVLEAAAkrHGGFSLHFTEFPWSCDYYKEHGKMMPEDGLEKLKKFDAIFLGAVGWPA---- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603   82 edlsKRPEK-----GLLGLRKHLGLFGNLRPALLYPQLAeaSSLKPELVSGLDIMIVRELTGGIYFGHP----RGTEERd 152
Cdd:TIGR02089  81 ----LVPDHislwgLLLKIRREFDQYANVRPAKLLPGVT--SPLRNCGPGDFDFVVVRENSEGEYSGVGgrihRGTDEE- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603  153 gerVGYNTYVYGEAEIERIGRVAFEMAQKRGGKLCSVDKANVLEVTM-LWRDVMERLAPEYPDVELSHMYVDNAAMQLVR 231
Cdd:TIGR02089 154 ---VATQNAIFTRKGVERIMRFAFELAQKRRKHLTSATKSNGIRHSMpFWDEVFAEVAAEYPDVEWDSYHIDALAARFVL 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603  232 APKQFDVVVTGNMFGDILSDAAAMLTGSIGMLPSASLNESGQ--GMFEPCHGSAPDIAGRDLANPLAMMLSVAMMLRYsL 309
Cdd:TIGR02089 231 KPETFDVIVASNLFGDILSDLGAALMGSLGVAPSANINPEGKfpSMFEPVHGSAPDIAGKGIANPIGAIWTAAMMLEH-L 309

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 515999603  310 GETALAERIEAAVGRVLDDGLRTADLADDSAraigTRAMGDAVLEA 355
Cdd:TIGR02089 310 GEKEAGAKIMDAIERVTAAGILTPDVGGKAT----TSEVTEAVCNA 351
PRK08997 PRK08997
isocitrate dehydrogenase; Provisional
 1-354 5.27e-75

isocitrate dehydrogenase; Provisional


Pssm-ID: 181606  Cd Length: 334  Bit Score: 235.00  E-value: 5.27e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603   1 MTRKVLLLPGDGIGPEITDQAARLLGAcqtAGLDIDVEKALVGGAAYDAHGEPLPAPTLEKARAADAVLLGAVGGPKWDA 80
Cdd:PRK08997   1 MKQTITVIPGDGIGPSIIDATLKILDK---LGCDFEYEFADAGLTALEKHGELLPQRTLDLIEKNKIALKGPLTTPVGEG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603  81 VEDLSkrpekglLGLRKHLGLFGNLRPALLYPQLAEAsslkpelVSGLDIMIVRELTGGIYFGHPRGTEErDGErVGYNT 160
Cdd:PRK08997  78 FTSIN-------VTLRKKFDLYANVRPVLSFPGTKAR-------YDNIDIITVRENTEGMYSGEGQTVSE-DGE-TAEAT 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 161 YVYGEAEIERIGRVAFEMAQKRG-GKLCSVDKANVLEVTM-LWRDVMERLAPEYPDVELSHMYVDNAAMQLVRAPKQFDV 238
Cdd:PRK08997 142 SIITRKGAERIVRFAYELARKEGrKKVTAVHKANIMKSTSgLFLKVAREVALRYPDIEFEEMIVDATCMQLVMNPEQFDV 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 239 VVTGNMFGDILSDAAAMLTGSIGMLPSASLNEsGQGMFEPCHGSAPDIAGRDLANPLAMMLSVAMMLRYsLGETALAERI 318
Cdd:PRK08997 222 IVTTNLFGDILSDLCAGLVGGLGMAPGANIGR-DAAIFEAVHGSAPDIAGKNLANPTSVILAAIQMLEY-LGMPDKAERI 299

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 515999603 319 EAAVGRVLDDGLR-TADLADDSaraiGTRAMGDAVLE 354
Cdd:PRK08997 300 RKAIVAVIEAGDRtTRDLGGTH----GTTDFTQAVID 332
AksF_Meth NF040619
homoisocitrate dehydrogenase;
2-352 1.82e-72

homoisocitrate dehydrogenase;


Pssm-ID: 468591  Cd Length: 332  Bit Score: 228.49  E-value: 1.82e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603   2 TRKVLLLPGDGIGPEITDQAARLLGACQtaglDIDVEKALVGGAAYDAHGEPLPAPTLEKARAADAVLLGAVGGPKWDAV 81
Cdd:NF040619   1 MPKICVIEGDGIGKEVIPETVRVLKELG----DFEFIKGEAGLECFKKYGDAIPEETIEKAKECDAILFGAVTTPKPTEL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603  82 EDLSKRPEkgLLGLRKHLGLFGNLRPALLYPQLaeasslkpELVSGLDIMIVRELTGGIYFGHPRGTEERD---GERVgy 158
Cdd:NF040619  77 KNKNYKSP--ILTLRKELDLYANVRPINNFGDG--------QDVKNIDFVIIRENTEGLYVGREYYDEENEiaiAERI-- 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 159 ntyvYGEAEIERIGRVAFEMAQKRGGKLCS-VDKANVLEVT-MLWRDVMERLAPEY--PDVELSHMYVDNAAMQLVRAPK 234
Cdd:NF040619 145 ----ISKKGSERIIKFAFEYAKKNNRKKVScIHKANVLRVTdGLFLEIFNEIKKKYknFNIEADDYLVDATAMYLIKNPE 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 235 QFDVVVTGNMFGDILSDAAAMLTGSIGMLPSASLNESgQGMFEPCHGSAPDIAGRDLANPLAMMLSVAMMLRYsLGETAL 314
Cdd:NF040619 221 MFDVIVTTNLFGDILSDEASGLIGGLGLAPSANIGDK-KGLFEPVHGSAPDIAGKGIANPIATILSAAMMLDY-LGMKEK 298

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 515999603 315 AERIEAAVGRVLDDGLRTADLADDsaraIGTRAMGDAV 352
Cdd:NF040619 299 GDLIREAVKKCLENGKVTPDLGGN----LKTKEVTDKI 332
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
1-359 9.57e-71

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 228.62  E-value: 9.57e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603   1 MTRKVLLLPGDGIGPEITDQAARLLGAcqtAGLDIDVEKALVGGAAYD---AHG-EPLPAPTLEKARaadaVLLGA---- 72
Cdd:PRK09222   3 EKTPITVAYGDGIGPEIMEAVLKILEA---AGAPLEIETIEIGEKVYKkgwTSGiSPSAWESIRRTK----VLLKApitt 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603  73 -VGGPkwdavedlskrpEKGL-LGLRKHLGLFGNLRPALLYPQLAEASSlkpelvSGLDIMIVRE----LTGGIyfghpr 146
Cdd:PRK09222  76 pQGGG------------YKSLnVTLRKTLGLYANVRPCVSYHPFVETKH------PNLDVVIIREneedLYAGI------ 131

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 147 gtEERDGERVGYNTYVYGEAEIERIGRVAFEMAQKRGGK--LCSVdKANVLEVT-MLWRDVMERLAPEYPDVELSHMYVD 223
Cdd:PRK09222 132 --EHRQTPDVYQCLKLISRPGSEKIIRYAFEYARANGRKkvTCLT-KDNIMKLTdGLFHKVFDEIAKEYPDIEAEHYIVD 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 224 NAAMQLVRAPKQFDVVVTGNMFGDILSDAAAMLTGSIGMLPSASLNESGqGMFEPCHGSAPDIAGRDLANPLAMMLSVAM 303
Cdd:PRK09222 209 IGAARLATNPENFDVIVTPNLYGDILSDIAAEISGSVGLAGSANIGEEY-AMFEAVHGSAPDIAGKNIANPSGLLNAAVM 287

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 515999603 304 MLRYsLGETALAERIEAAVGRVLDDGLRTADLADD--SARAIGTRAMGDAVLEAFAQQ 359
Cdd:PRK09222 288 MLVH-IGQFDIAELIENAWLKTLEDGIHTADIYNEgvSKKKVGTKEFAEAVIENLGQK 344
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
 4-358 3.01e-69

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 220.75  E-value: 3.01e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603   4 KVLLLPGDGIGPEITDQAARLLGACQTA--GLDIDVEKALVGGAAYDAHGEPLPAPTLEKARAADAVLLGAVGGPKwdAV 81
Cdd:PRK08194   5 KIAVIPGDGVGKEVVPAAVRVLKAVAEVhgGLKFEFTEFPWSCEYYLEHGEMMPEDGLEQLKQFDAIFLGAVGNPK--LV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603  82 EDlskrpEKGLLGL----RKHLGLFGNLRPALLYPqlaeasSLKPELVS--GLDIMIVRELTGGIYfGHPRGTEERDGER 155
Cdd:PRK08194  83 PD-----HISLWGLlikiRREFEQVINIRPAKQLR------GIKSPLANpkDFDLLVVRENSEGEY-SEVGGRIHRGEDE 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 156 VGYNTYVYGEAEIERIGRVAFEMAQKRGGKLCSVDKANVLEVTM-LWRDVMERLAPEYPDVELSHMYVDNAAMQLVRAPK 234
Cdd:PRK08194 151 IAIQNAVFTRKGTERAMRYAFELAAKRRKHVTSATKSNGIVHSMpFWDEVFQEVGKDYPEIETDSQHIDALAAFFVTRPE 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 235 QFDVVVTGNMFGDILSDAAAMLTGSIGMLPSASLNESGQ--GMFEPCHGSAPDIAGRDLANPLAMMLSVAMMLRYsLGET 312
Cdd:PRK08194 231 EFDVIVASNLFGDILTDIGAAIMGSIGIAPAANINVNGKypSMFEPVHGSAPDIAGKGIANPIGQIWTAKLMLDH-FGEE 309

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 515999603 313 ALAERIEAAVGRVLDDGLRTADLADDSaraiGTRAMGDAVLEAFAQ 358
Cdd:PRK08194 310 ELGSHLLDVIEDVTEDGIKTPDIGGRA----TTDEVTDEIISRLKK 351
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
 3-336 7.65e-61

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


Pssm-ID: 272942  Cd Length: 333  Bit Score: 198.37  E-value: 7.65e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603    3 RKVLLLPGDGIGPEITDQAARLLGACqtaGLDIDVEKALVggAAYDAHGEPLPAPTLEKARAADAVLLGAVGGPkwdave 82
Cdd:TIGR00175   4 YTVTLIPGDGIGPEISGSVKKIFRAA---NVPIEFEEIDV--SPQTDGKTEIPDEAVESIKRNKVALKGPLETP------ 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603   83 dLSKRPEKGL-LGLRKHLGLFGNLRPALLYPQLaeasslkPELVSGLDIMIVRELTGGIYFG--HprgtEERDGerVGYN 159
Cdd:TIGR00175  73 -IGKGGHRSLnVALRKELDLYANVVHCKSLPGF-------KTRHEDVDIVIIRENTEGEYSGleH----ESVPG--VVES 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603  160 TYVYGEAEIERIGRVAFEMAQKRGGK-LCSVDKANVLEVT-MLWRDVMERLAPEYPDVELSHMYVDNAAMQLVRAPKQFD 237
Cdd:TIGR00175 139 LKVITRDKSERIARYAFEYARKNGRKkVTAVHKANIMKLAdGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFD 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603  238 VVVTGNMFGDILSDAAAMLTGSIGMLPSASLNESGQGMFEPCHGSAPDIAGRDLANPLAMMLSVAMMLRYsLGETALAER 317
Cdd:TIGR00175 219 VMVMPNLYGNILSNLGAGLVGGPGLVPGANIGRDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMMLNH-LGLKEHADR 297

                         330       340
                  ....*....|....*....|
gi 515999603  318 IEAAVGRVLDDG-LRTADLA 336
Cdd:TIGR00175 298 IQKAVLSTIAEGkNRTKDLG 317
ICDH_alpha TIGR02924
isocitrate dehydrogenase; This family of mainly alphaproteobacterial enzymes is a member of ...
 10-358 1.01e-60

isocitrate dehydrogenase; This family of mainly alphaproteobacterial enzymes is a member of the isocitrate/isopropylmalate dehydrogenase superfamily described by pfam00180. Every member of the seed of this model appears to have a TCA cycle lacking only a determined isocitrate dehydrogenase. The precise identity of the cofactor (NADH -- 1.1.1.41 vs. NADPH -- 1.1.1.42) is unclear. [Energy metabolism, TCA cycle]


Pssm-ID: 274353 [Multi-domain]  Cd Length: 473  Bit Score: 202.30  E-value: 1.01e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603   10 GDGIGPEITDQAARLLGAcqtAGLDIDVEKALVGGAAYDAHGEPLPAP-TLEKARAADAVLLGAVGGPKWDAVEDLSkrp 88
Cdd:TIGR02924   8 GDGIGPEIMEAVLLILKE---AEAPIDIETIEIGEKVYKKGWPSGISPsSWESIRRTKVLLKAPITTPQGGGHKSLN--- 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603   89 ekglLGLRKHLGLFGNLRPALLYPQLAEASSlkpelvSGLDIMIVRELTGGIYfghpRGTEERDGERVGYNTYVYGEAEI 168
Cdd:TIGR02924  82 ----VTLRKTLGLYANIRPCVSYHPFIETKS------PNLNIVIVRENEEDLY----TGIEYRQTPDTYECTKLITRSGS 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603  169 ERIGRVAFEMAQKRGGKLCSV-DKANVLEVT-MLWRDVMERLAPEYPDVELSHMYVDNAAMQLVRAPKQFDVVVTGNMFG 246
Cdd:TIGR02924 148 EKICRYAFEYARKHNRKKVTClTKDNIMKMTdGIFHKIFDKIAAEYPDIESEHYIVDIGMARLATNPENFDVIVTPNLYG 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603  247 DILSDAAAMLTGSIGMLPSASLNESGqGMFEPCHGSAPDIAGRDLANPLAMMLSVAMMLRYsLGETALAERIEAAVGRVL 326
Cdd:TIGR02924 228 DILSDVAAEISGSVGLAGSANIGEEY-AMFEAVHGSAPDIAGQNIANPSGLLNAAIQMLVH-IGQSDIAQLIYNAWLKTL 305

                         330       340       350
                  ....*....|....*....|....*....|....
gi 515999603  327 DDGLRTADL--ADDSARAIGTRAMGDAVLEAFAQ 358
Cdd:TIGR02924 306 EDGVHTADIynEKTSKQKVGTKEFAEAVTANLGK 339
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 7-350 4.03e-49

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 169.29  E-value: 4.03e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603   7 LLPGDGIGPEITDQAARLLGAcqtAGLDIDVEKALVGGAAYDAHGEPLPAPTLEKARAADAVLLGAVGGPKWDAVEDLSk 86
Cdd:PLN00118  46 LFPGDGIGPEIAESVKQVFTA---AGVPIEWEEHYVGTTVDPRTGSFLTWESLESVRRNKVGLKGPMATPIGKGHRSLN- 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603  87 rpekglLGLRKHLGLFGNLRPALLYPQLAEAsslkpelVSGLDIMIVRELTGGIYfghpRGTEERDGERVGYNTYVYGEA 166
Cdd:PLN00118 122 ------LTLRKELGLYANVRPCYSLPGYKTR-------YDDVDLVTIRENTEGEY----SGLEHQVVRGVVESLKIITRQ 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 167 EIERIGRVAFEMAQKRGGKLCS-VDKANVLEVT-MLWRDVMERLAPEYPDVELSHMYVDNAAMQLVRAPKQFDVVVTGNM 244
Cdd:PLN00118 185 ASLRVAEYAFHYAKTHGRKRVSaIHKANIMKKTdGLFLKCCREVAEKYPEIVYEEVIIDNCCMMLVKNPALFDVLVMPNL 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 245 FGDILSDAAAMLTGSIGMLPSASLNESGQGMFEPCHGSAPDIAGRDLANPLAMMLSVAMMLRYsLGETALAERIEAAVGR 324
Cdd:PLN00118 265 YGDIISDLCAGLIGGLGLTPSCNIGENGLALAEAVHGSAPDIAGKNLANPTALLLSAVMMLRH-LKLNEQAEQIHNAILN 343

                        330       340
                 ....*....|....*....|....*..
gi 515999603 325 VLDDG-LRTADLADDSARAIGTRAMGD 350
Cdd:PLN00118 344 TIAEGkYRTADLGGSSTTTDFTKAICD 370
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 10-354 1.49e-41

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 149.88  E-value: 1.49e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603  10 GDGIGPEITDQAARLL-GACQTA---GLDIDVEKALVGGAAYDAHGEPLPAPTLEKARAADAVLLGAVGGPkwdaVEDLS 85
Cdd:COG0538   26 GDGIGPEITRAIWKVIdAAVEKAyggKRDIEWKEVDAGEKARDETGDWLPDETAEAIKEYGVGIKGPLTTP----VGGGW 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603  86 KRPEkglLGLRKHLGLFGNLRPALLYPQLAeaSSLK-PELVsglDIMIVRELTGGIYFG--HPRGTEE--------RDGE 154
Cdd:COG0538  102 RSLN---VTIRQILDLYVCRRPVRYFKGVP--SPVKhPEKV---DIVIFRENTEDIYAGieWKAGSPEalklifflEDEM 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 155 RVGYNTY---------VYGEAEIERIGRVAFEMAQKRGGK-LCSVDKANVLEVT----MLW-----------RDVMERLA 209
Cdd:COG0538  174 GVTVIRFpedsgigikPVSDEGTERLVRAAIQYALDNKRKsVTLVHKGNIMKFTegafKDWgyevaeeefgdKFITEGPW 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 210 PEYP------DVELSHMYVDNAAMQLVRAPKQFDVVVTGNMFGDILSDAAAMLTGSIGMLPSASLNESGQGMFEPCHGSA 283
Cdd:COG0538  254 EKYKgpkpagKIVYKDRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGANIGDDGGAEFEATHGTA 333

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 515999603 284 PDIAGRDLANPLAMMLSVAMMLRYsLGETALAERIEAAVGRVLDDGLRTADLAD--DSARAIGTRAMGDAVLE 354
Cdd:COG0538  334 PKYAGKDSTNPGSLILSGTMMLRH-RGWLEAADLIEKAVEKTIESGKVTYDLARlmEGATELSTSEFGDAIIE 405
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 3-355 1.45e-39

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 143.47  E-value: 1.45e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603   3 RKVLLLPGDGIGPEITDQAARLLGACQtagldidvekALVGGAAYDAHG--EPLPAPTLEKARAADAVLLGAVGGPKWDA 80
Cdd:PLN00123  31 RAVTLIPGDGIGPLVTGAVEQVMEAMH----------APVYFERYEVHGdmKKVPEEVLESIRRNKVCLKGGLATPVGGG 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603  81 VEDLSkrpekglLGLRKHLGLFGNLRPALLYPQLaeasslkPELVSGLDIMIVRELTGGIYfghpRGTEERDGERVGYNT 160
Cdd:PLN00123 101 VSSLN-------VQLRKELDLFASLVNCFNLPGL-------PTRHENVDIVVIRENTEGEY----SGLEHEVVPGVVESL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 161 YVYGEAEIERIGRVAFEMAQ-KRGGKLCSVDKANVLEVT-MLWRDVMERLAPEYPDVELSHMYVDNAAMQLVRAPKQFDV 238
Cdd:PLN00123 163 KVITKFCSERIAKYAFEYAYlNNRKKVTAVHKANIMKLAdGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQFDV 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 239 VVTGNMFGDILSDAAAMLTGSIGMLPSASLNeSGQGMFEPCHGSA----PDIAGRDLANPLAMMLSVAMMLRYsLGETAL 314
Cdd:PLN00123 243 MVTPNLYGNLVANTAAGIAGGTGVMPGGNVG-ADHAVFEQGASAGnvgnEKLVEQKKANPVALLLSSAMMLRH-LQFPSF 320

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 515999603 315 AERIEAAVGRVLDDG-LRTADLADDSAraigTRAMGDAVLEA 355
Cdd:PLN00123 321 ADRLETAVKRVIAEGkYRTKDLGGSST----TQEVVDAVIAN 358
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
5-354 5.97e-35

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 132.26  E-value: 5.97e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603   5 VLLLPGDGIGPEITDQAARLLgacqtaglDIDVEKA------------LVGGAAYDAHGEPLPAPTLEKARAADAVLLGA 72
Cdd:PRK06451  26 ILYVEGDGIGPEITHAAMKVI--------NKAVEKAygsdreikwvevLAGDKAEKLTGNRFPKESEELIEKYRVLLKGP 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603  73 VGGP---KWDAVEdlskrpekglLGLRKHLGLFGNLRPALLYPQLAeaSSLK-PELVsglDIMIVRELTGGIYFG--HPR 146
Cdd:PRK06451  98 LETPigkGWKSIN----------VAIRLMLDLYANIRPVKYIPGIE--SPLKnPEKI---DLIIFRENTDDLYRGieYPY 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 147 GTEE----RDGERVGYNTYVYGEAEI----------ERIGRVAFEMA-QKRGGKLCSVDKANVLEVTM-LWRDVMERLA- 209
Cdd:PRK06451 163 DSEEakkiRDFLRKELGVEVEDDTGIgikliskfktQRIARMAIKYAiDHKRKKVTIMHKGNVMKYTEgAFREWAYEVAl 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 210 PEYPDV-----ELSHMY---------------VDNAAMQLVRAPKQFDVVVTGNMFGDILSDAAAMLTGSIGMLPSASLN 269
Cdd:PRK06451 243 KEFRDYvvteeEVTKNYngvppsgkviindriADNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANIG 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 270 ESGqGMFEPCHGSAPDIAGRDLANPLAMMLSVAMMLRYsLGETALAERIEAAVGRVLDDGLRTADLAD-DSARAIGTRAM 348
Cdd:PRK06451 323 DTG-GMFEAIHGTAPKYAGKNVANPTGIIKGGELMLRF-MGWDKAADLIDKAIMESIKQKKVTQDLARfMGVRALSTTEY 400


                 ....*.
gi 515999603 349 GDAVLE 354
Cdd:PRK06451 401 TDELIS 406
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 10-354 5.37e-27

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 110.15  E-value: 5.37e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603  10 GDGIGPEITDQAARLLGACqtagldidVEKA------------LVGGAAYDAHGEP--LPAPTLEKAR----AADAVLLG 71
Cdd:PRK07006  27 GDGIGPDITPAMLKVVDAA--------VEKAykgerkiswmeiYAGEKATKVYGEDvwLPEETLDLIReyrvAIKGPLTT 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603  72 AVGGpkwdAVEDLSkrpekglLGLRKHLGLFGNLRPALLYPQLAeaSSLK-PELVsglDIMIVRELTGGIYFG--HPRGT 148
Cdd:PRK07006  99 PVGG----GIRSLN-------VALRQELDLYVCLRPVRYFKGVP--SPVKrPEDT---DMVIFRENSEDIYAGieWKAGS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 149 EE-----------------RDGERVGYNTYVYGEAEIERIGRVAFEMAQKRGGK-LCSVDKANVLEVTM-LWRDVMERLA 209
Cdd:PRK07006 163 AEakkvikflqeemgvkkiRFPETSGIGIKPVSEEGTERLVRAAIEYAIDNDRKsVTLVHKGNIMKFTEgAFKDWGYQLA 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 210 PEYPDVEL----SHMYVDNAA----------------MQLVRAPKQFDVVVTGNMFGDILSDAAAMLTGSIGMLPSASLN 269
Cdd:PRK07006 243 EEEFGDELidggPWDKIKNPEtgkeiivkdsiadaflQQILLRPAEYDVIATMNLNGDYISDALAAQVGGIGIAPGANIN 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 270 eSGQGMFEPCHGSAPDIAGRDLANPLAMMLSVAMMLRYsLGETALAERIEAAVGRVLDDGLRTADLAD--DSARAIGTRA 347
Cdd:PRK07006 323 -DGHAIFEATHGTAPKYAGLDKVNPGSVILSAEMMLRH-MGWTEAADLIIKSMEKTIASKTVTYDFARlmEGATEVKCSE 400


                 ....*..
gi 515999603 348 MGDAVLE 354
Cdd:PRK07006 401 FGDALIK 407
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
223-336 1.43e-15

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 77.45  E-value: 1.43e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515999603 223 DNAAMQLVRAPKQFDVVVTGNMFGDILSDAAAMLTGSIGMLPSASLNESGqGMFEPCHGSAPDIAGRDLANPLAMMLSVA 302
Cdd:PRK07362 340 DSIFQQIQTRPQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIGDNA-AIFEATHGTAPKHAGLDRINPGSVILSGV 418

                         90       100       110
                 ....*....|....*....|....*....|....
gi 515999603 303 MMLRYsLGETALAERIEAAVGRVLDDGLRTADLA 336
Cdd:PRK07362 419 MMLEY-LGWQEAADLITKGLSAAIANKQVTYDLA 451
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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