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Conserved domains on  [gi|515995290|ref|WP_017425873|]
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MULTISPECIES: helix-turn-helix domain-containing protein [Paenibacillus]

Protein Classification

winged helix-turn-helix transcriptional regulator( domain architecture ID 10004391)

winged helix-turn-helix (HTH) transcriptional regulator containing a HxlR family HTH domain; similar to HTH-type transcriptional regulator HxlR, a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|10679470|10908318

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
2-101 1.38e-43

DNA-binding transcriptional regulator, HxlR family [Transcription];


:

Pssm-ID: 441339  Cd Length: 108  Bit Score: 138.08  E-value: 1.38e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515995290   2 KQYNLGIEATLEIIGGKWKSLIICLLMSGRKRTSELQRSIAGISQKVLIQQLRELEKDGIIGRHVYNQMPPKVEYYITEY 81
Cdd:COG1733    6 KEADCPVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLTEK 85

                         90       100
                 ....*....|....*....|
gi 515995290  82 GITANEIIDLMCTWGRTNIK 101
Cdd:COG1733   86 GRSLLPVLDALAEWGEEHLP 105
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
2-101 1.38e-43

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 138.08  E-value: 1.38e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515995290   2 KQYNLGIEATLEIIGGKWKSLIICLLMSGRKRTSELQRSIAGISQKVLIQQLRELEKDGIIGRHVYNQMPPKVEYYITEY 81
Cdd:COG1733    6 KEADCPVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLTEK 85

                         90       100
                 ....*....|....*....|
gi 515995290  82 GITANEIIDLMCTWGRTNIK 101
Cdd:COG1733   86 GRSLLPVLDALAEWGEEHLP 105
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 14-100 6.15e-34

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 112.78  E-value: 6.15e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515995290   14 IIGGKWKSLIICLLMSGRKRTSELQRSIAGISQKVLIQQLRELEKDGIIGRHVYNQMPPKVEYYITEYGITANEIIDLMC 93
Cdd:pfam01638   1 LIGGKWKGLILRELLDGKKRFSELKRAIPGITQKMLTQRLRELEQDGIINREVYPEVPPKVEYSLTEKGRSLEPILQELC 80


                  ....*..
gi 515995290   94 TWGRTNI 100
Cdd:pfam01638  81 DWGEEYL 87
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 12-67 2.02e-05

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 39.59  E-value: 2.02e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515995290  12 LEIIGGKWKSLIICLLMSGRKRTSELQRsIAGISQKVLIQQLRELEKDGII-----GRHVY 67
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPLTVSELAE-RLGLSQSTVSRHLKKLEEAGLVesrreGRRVY 60
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
23-81 7.72e-04

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 35.26  E-value: 7.72e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 515995290    23 IICLLMSGRKRTSELQRsIAGISQKVLIQQLRELEKDGII-----GRHVYNQM-PPKVEYYITEY 81
Cdd:smart00418   2 ILKLLAEGELCVCELAE-ILGLSQSTVSHHLKKLREAGLVesrreGKRVYYSLtDEKVADLLEEL 65
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
2-101 1.38e-43

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 138.08  E-value: 1.38e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515995290   2 KQYNLGIEATLEIIGGKWKSLIICLLMSGRKRTSELQRSIAGISQKVLIQQLRELEKDGIIGRHVYNQMPPKVEYYITEY 81
Cdd:COG1733    6 KEADCPVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLTEK 85

                         90       100
                 ....*....|....*....|
gi 515995290  82 GITANEIIDLMCTWGRTNIK 101
Cdd:COG1733   86 GRSLLPVLDALAEWGEEHLP 105
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 14-100 6.15e-34

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 112.78  E-value: 6.15e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515995290   14 IIGGKWKSLIICLLMSGRKRTSELQRSIAGISQKVLIQQLRELEKDGIIGRHVYNQMPPKVEYYITEYGITANEIIDLMC 93
Cdd:pfam01638   1 LIGGKWKGLILRELLDGKKRFSELKRAIPGITQKMLTQRLRELEQDGIINREVYPEVPPKVEYSLTEKGRSLEPILQELC 80


                  ....*..
gi 515995290   94 TWGRTNI 100
Cdd:pfam01638  81 DWGEEYL 87
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 12-67 2.02e-05

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 39.59  E-value: 2.02e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515995290  12 LEIIGGKWKSLIICLLMSGRKRTSELQRsIAGISQKVLIQQLRELEKDGII-----GRHVY 67
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPLTVSELAE-RLGLSQSTVSRHLKKLEEAGLVesrreGRRVY 60
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
23-67 5.24e-05

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 39.10  E-value: 5.24e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 515995290  23 IICLLMSGRKRTSELQRsIAGISQKVLIQQLRELEKDGII-----GRHVY 67
Cdd:COG0640   25 ILRLLAEGELCVGELAE-ALGLSQSTVSHHLKVLREAGLVtsrreGRWVY 73
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
23-81 7.72e-04

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 35.26  E-value: 7.72e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 515995290    23 IICLLMSGRKRTSELQRsIAGISQKVLIQQLRELEKDGII-----GRHVYNQM-PPKVEYYITEY 81
Cdd:smart00418   2 ILKLLAEGELCVCELAE-ILGLSQSTVSHHLKKLREAGLVesrreGKRVYYSLtDEKVADLLEEL 65
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
8-83 2.35e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 35.01  E-value: 2.35e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 515995290   8 IEATLEIIGGKWKSLIICLLMSGRKRTSELQRSIaGISQKVLIQQLRELEKDGII--GRHVYNQMPPKVEYYITEYGI 83
Cdd:COG1777    7 LDRLLDALGNPTRRRILALLSEEPAYVSELAREL-GVSRQAVYKHLRKLEEAGLVesYREGREDGRARKYYRLSAFRL 83
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 20-62 4.58e-03

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 32.80  E-value: 4.58e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 515995290   20 KSLIICLLMSGRKRTSELQRsIAGISQKVLIQQLRELEKDGII 62
Cdd:pfam01022   4 RLKILKLLAEGELCVCELAE-ELGLSQSTVSHHLKKLREAGLV 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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