NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|515989829|ref|WP_017420412|]
View 

heme biosynthesis protein HemY [Vibrio vulnificus]

Protein Classification

heme biosynthesis protein HemY( domain architecture ID 11489224)

heme biosynthesis protein HemY similar to Escherichia coli HemY, is found in heme biosynthesis gene clusters and contains tetratricopeptide repeats (TPRs)

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TPR_hemY_coli TIGR00540
heme biosynthesis-associated TPR protein; Members of this protein family are uncharacterized ...
 22-386 2.92e-113

heme biosynthesis-associated TPR protein; Members of this protein family are uncharacterized tetratricopeptide repeat (TPR) proteins invariably found in heme biosynthesis gene clusters. The absence of any invariant residues other than Ala argues against this protein serving as an enzyme per se. The gene symbol hemY assigned in E. coli is unfortunate in that an unrelated protein, protoporphyrinogen oxidase (HemG in E. coli) is designated HemY in Bacillus subtilis. [Unknown function, General]


:

Pssm-ID: 273126 [Multi-domain]  Cd Length: 367  Bit Score: 335.41  E-value: 2.92e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829   22 SGQQGYVLISIANTTIEMSVTTLVIFIVAALAGLFGLEYLVKKVLYTGFTTWNWFSVRKMRRSRRYTNEGIIKLLEGDWK 101
Cdd:TIGR00540   3 AGNTGYVLIVYPPYRIELSLNFFVLLLVLLFVVLYILLRLIRRVFRLPRRVRAWRSRRKQRRAQQATREGLIALFEGRYS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829  102 GAEKKVTRWASHHDMPLLCYLVASEAADGQGDKAKRDHYLALAAE-QENAYLAVELTRSKQLVREGEFAQAFDSLQSLKG 180
Cdd:TIGR00540  83 QAEKKATKAAEHSENPLLAYLLAARAAQQMGDEERRDRYLAEAAElAPNSELAVLLTRAELLLDQRDYEAALAALDSLQA 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829  181 RYPNNPIVLNLLKTTYLELKLWQPLIDLLPTLNKQALISPEDAEQMHQRAQCGLLADvAGQQGSEGLIKHWNTLPRKVKQ 260
Cdd:TIGR00540 163 QAPRHTAVLRLALRAYQRSGNWDALLKLLPALRKAKALSPEEAARLEQQAYIGLLDE-AREEDADALKTWWKQLPRAERQ 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829  261 DPHLVACFAKQLISRKADHEALTVIKEALKKSPSPELYALLPQLNLGDVHPVVVMLEQNVKNDSQNAEAHSALAQLYFRE 340
Cdd:TIGR00540 242 EPELAVAAAEALIQLGDHDEAEKLIEEALKKEWDPELLRLYGRLQPGDPSPLIKRAEKWLKKHPDDALLLLALGRLCLRQ 321

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 515989829  341 GKWPQAQSHFETALKVRSSVSDYAFLADALEKQNLNKAAHEVSRKA 386
Cdd:TIGR00540 322 QLWGKAQSYLEASLSLAPTEEAHLELAQLFEQLGDTEAAAQHYRKS 367
 
Name Accession Description Interval E-value
TPR_hemY_coli TIGR00540
heme biosynthesis-associated TPR protein; Members of this protein family are uncharacterized ...
 22-386 2.92e-113

heme biosynthesis-associated TPR protein; Members of this protein family are uncharacterized tetratricopeptide repeat (TPR) proteins invariably found in heme biosynthesis gene clusters. The absence of any invariant residues other than Ala argues against this protein serving as an enzyme per se. The gene symbol hemY assigned in E. coli is unfortunate in that an unrelated protein, protoporphyrinogen oxidase (HemG in E. coli) is designated HemY in Bacillus subtilis. [Unknown function, General]


Pssm-ID: 273126 [Multi-domain]  Cd Length: 367  Bit Score: 335.41  E-value: 2.92e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829   22 SGQQGYVLISIANTTIEMSVTTLVIFIVAALAGLFGLEYLVKKVLYTGFTTWNWFSVRKMRRSRRYTNEGIIKLLEGDWK 101
Cdd:TIGR00540   3 AGNTGYVLIVYPPYRIELSLNFFVLLLVLLFVVLYILLRLIRRVFRLPRRVRAWRSRRKQRRAQQATREGLIALFEGRYS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829  102 GAEKKVTRWASHHDMPLLCYLVASEAADGQGDKAKRDHYLALAAE-QENAYLAVELTRSKQLVREGEFAQAFDSLQSLKG 180
Cdd:TIGR00540  83 QAEKKATKAAEHSENPLLAYLLAARAAQQMGDEERRDRYLAEAAElAPNSELAVLLTRAELLLDQRDYEAALAALDSLQA 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829  181 RYPNNPIVLNLLKTTYLELKLWQPLIDLLPTLNKQALISPEDAEQMHQRAQCGLLADvAGQQGSEGLIKHWNTLPRKVKQ 260
Cdd:TIGR00540 163 QAPRHTAVLRLALRAYQRSGNWDALLKLLPALRKAKALSPEEAARLEQQAYIGLLDE-AREEDADALKTWWKQLPRAERQ 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829  261 DPHLVACFAKQLISRKADHEALTVIKEALKKSPSPELYALLPQLNLGDVHPVVVMLEQNVKNDSQNAEAHSALAQLYFRE 340
Cdd:TIGR00540 242 EPELAVAAAEALIQLGDHDEAEKLIEEALKKEWDPELLRLYGRLQPGDPSPLIKRAEKWLKKHPDDALLLLALGRLCLRQ 321

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 515989829  341 GKWPQAQSHFETALKVRSSVSDYAFLADALEKQNLNKAAHEVSRKA 386
Cdd:TIGR00540 322 QLWGKAQSYLEASLSLAPTEEAHLELAQLFEQLGDTEAAAQHYRKS 367
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 88-389 1.60e-88

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 270.63  E-value: 1.60e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829  88 TNEGIIKLLEGDWKGAEKKVTRWASHHDMPLLCYLVASEAADGQGDKAKRDHYLALAAEQ-ENAYLAVELTRSKQLVREG 166
Cdd:COG3071   20 LLEGLLALAEGRYARAEKLLSKAAEHSEAPLLAYLLAARAAQALGDYERRDEYLAQALELaPEAELAVLLTRAELLLDQG 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829 167 EFAQAFDSLQSLKGRYPNNPIVLNLLKTTYLELKLWQPLIDLLPTLNKQALISPEDAEQMHQRAQCGLLADVAgqQGSEG 246
Cdd:COG3071  100 QAEQALATLEALRAGAPRHPQVLRLLLQAYRQLGDWEELLELLPALRKHKALSAEEAQALERRAYLGLLRQAA--RDAEA 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829 247 LIKHWNTLPRKVKQDPHLVACFAKQLISRKADHEALTVIKEALKKSPSPELYALLPQLNLGDVHPVVVMLEQNVKNDSQN 326
Cdd:COG3071  178 LKALWKALPRAERRDPELAAAYARALIALGDHDEAERLLREALKRQWDPRLVRLYGRLQGGDPAKQLKRAEKWLKKHPND 257

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 515989829 327 AEAHSALAQLYFREGKWPQAQSHFETALKVRSSVSDYAFLADALEKQNLNKAAHEVSRKALTL 389
Cdd:COG3071  258 PDLLLALGRLCLRNQLWGKAREYLEAALALRPSAEAYAELARLLEQLGDPEEAAEHYRKALAL 320
PRK10747 PRK10747
putative protoheme IX biogenesis protein; Provisional
 1-389 1.73e-86

putative protoheme IX biogenesis protein; Provisional


Pssm-ID: 182695 [Multi-domain]  Cd Length: 398  Bit Score: 267.73  E-value: 1.73e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829   1 MIRLIFLFVVLGAGLFVGTQFSGQQGYVLISIANTTIEMSVTTLVIFIVAALAGLFGLEYLVKKVLYTGFTTWNWFSVRK 80
Cdd:PRK10747   1 MLKVLLLFVLLIAGIVVGPMIAGHQGYVLIQTDNYNIETSVTGLAIILILAMVVLFAIEWLLRRIFRTGARTRGWFVGRK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829  81 MRRSRRYTNEGIIKLLEGDWKGAEKKVTRWASHHDMPLLCYLVASEAADGQGDKAKRDHYLALAAE-QENAYLAVELTRS 159
Cdd:PRK10747  81 RRRARKQTEQALLKLAEGDYQQVEKLMTRNADHAEQPVVNYLLAAEAAQQRGDEARANQHLERAAElADNDQLPVEITRV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829 160 KQLVREGEFAQAFDSLQSLKGRYPNNPIVLNLLKTTYLELKLWQPLIDLLPTLNKQALISPEDAEQMHQRAQCGLLADVA 239
Cdd:PRK10747 161 RIQLARNENHAARHGVDKLLEVAPRHPEVLRLAEQAYIRTGAWSSLLDILPSMAKAHVGDEEHRAMLEQQAWIGLMDQAM 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829 240 GQQGSEGLIKHWNTLPRKVKQDPHLVACFAKQLISRKaDHE-ALTVIKEALKKSPSPELYALLPQLNLGDVHPVVVMLEQ 318
Cdd:PRK10747 241 ADQGSEGLKRWWKNQSRKTRHQVALQVAMAEHLIECD-DHDtAQQIILDGLKRQYDERLVLLIPRLKTNNPEQLEKVLRQ 319

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515989829 319 NVKNDSQNAEAHSALAQLYFREGKWPQAQSHFETALKVRSSVSDYAFLADALEKQNLNKAAHEVSRKALTL 389
Cdd:PRK10747 320 QIKQHGDTPLLWSTLGQLLMKHGEWQEASLAFRAALKQRPDAYDYAWLADALDRLHKPEEAAAMRRDGLML 390
HemY_N pfam07219
HemY protein N-terminus; This family represents the N-terminus (approximately 150 residues) of ...
 29-132 2.69e-26

HemY protein N-terminus; This family represents the N-terminus (approximately 150 residues) of bacterial HemY porphyrin biosynthesis proteins. This is a membrane protein involved in a late step of protoheme IX synthesis.


Pssm-ID: 429353 [Multi-domain]  Cd Length: 104  Bit Score: 101.44  E-value: 2.69e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829   29 LISIANTTIEMSVTTLVIFIVAALAGLFGLEYLVKKVLYTGFTTWNWFSVRKMRRSRRYTNEGIIKLLEGDWKGAEKKVT 108
Cdd:pfam07219   1 LIVWGGYRIETSLWVAVLLLVLLFVLLYLLLRLLRLLLRLPGRVRRWRRRRRRRKARKALSEGLIALAEGDWAQAEKLAA 80

                          90       100
                  ....*....|....*....|....
gi 515989829  109 RWASHHDMPLLCYLVASEAADGQG 132
Cdd:pfam07219  81 KAAKLLDAPLLNYLLAARAAQLQG 104
 
Name Accession Description Interval E-value
TPR_hemY_coli TIGR00540
heme biosynthesis-associated TPR protein; Members of this protein family are uncharacterized ...
 22-386 2.92e-113

heme biosynthesis-associated TPR protein; Members of this protein family are uncharacterized tetratricopeptide repeat (TPR) proteins invariably found in heme biosynthesis gene clusters. The absence of any invariant residues other than Ala argues against this protein serving as an enzyme per se. The gene symbol hemY assigned in E. coli is unfortunate in that an unrelated protein, protoporphyrinogen oxidase (HemG in E. coli) is designated HemY in Bacillus subtilis. [Unknown function, General]


Pssm-ID: 273126 [Multi-domain]  Cd Length: 367  Bit Score: 335.41  E-value: 2.92e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829   22 SGQQGYVLISIANTTIEMSVTTLVIFIVAALAGLFGLEYLVKKVLYTGFTTWNWFSVRKMRRSRRYTNEGIIKLLEGDWK 101
Cdd:TIGR00540   3 AGNTGYVLIVYPPYRIELSLNFFVLLLVLLFVVLYILLRLIRRVFRLPRRVRAWRSRRKQRRAQQATREGLIALFEGRYS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829  102 GAEKKVTRWASHHDMPLLCYLVASEAADGQGDKAKRDHYLALAAE-QENAYLAVELTRSKQLVREGEFAQAFDSLQSLKG 180
Cdd:TIGR00540  83 QAEKKATKAAEHSENPLLAYLLAARAAQQMGDEERRDRYLAEAAElAPNSELAVLLTRAELLLDQRDYEAALAALDSLQA 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829  181 RYPNNPIVLNLLKTTYLELKLWQPLIDLLPTLNKQALISPEDAEQMHQRAQCGLLADvAGQQGSEGLIKHWNTLPRKVKQ 260
Cdd:TIGR00540 163 QAPRHTAVLRLALRAYQRSGNWDALLKLLPALRKAKALSPEEAARLEQQAYIGLLDE-AREEDADALKTWWKQLPRAERQ 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829  261 DPHLVACFAKQLISRKADHEALTVIKEALKKSPSPELYALLPQLNLGDVHPVVVMLEQNVKNDSQNAEAHSALAQLYFRE 340
Cdd:TIGR00540 242 EPELAVAAAEALIQLGDHDEAEKLIEEALKKEWDPELLRLYGRLQPGDPSPLIKRAEKWLKKHPDDALLLLALGRLCLRQ 321

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 515989829  341 GKWPQAQSHFETALKVRSSVSDYAFLADALEKQNLNKAAHEVSRKA 386
Cdd:TIGR00540 322 QLWGKAQSYLEASLSLAPTEEAHLELAQLFEQLGDTEAAAQHYRKS 367
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 88-389 1.60e-88

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 270.63  E-value: 1.60e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829  88 TNEGIIKLLEGDWKGAEKKVTRWASHHDMPLLCYLVASEAADGQGDKAKRDHYLALAAEQ-ENAYLAVELTRSKQLVREG 166
Cdd:COG3071   20 LLEGLLALAEGRYARAEKLLSKAAEHSEAPLLAYLLAARAAQALGDYERRDEYLAQALELaPEAELAVLLTRAELLLDQG 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829 167 EFAQAFDSLQSLKGRYPNNPIVLNLLKTTYLELKLWQPLIDLLPTLNKQALISPEDAEQMHQRAQCGLLADVAgqQGSEG 246
Cdd:COG3071  100 QAEQALATLEALRAGAPRHPQVLRLLLQAYRQLGDWEELLELLPALRKHKALSAEEAQALERRAYLGLLRQAA--RDAEA 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829 247 LIKHWNTLPRKVKQDPHLVACFAKQLISRKADHEALTVIKEALKKSPSPELYALLPQLNLGDVHPVVVMLEQNVKNDSQN 326
Cdd:COG3071  178 LKALWKALPRAERRDPELAAAYARALIALGDHDEAERLLREALKRQWDPRLVRLYGRLQGGDPAKQLKRAEKWLKKHPND 257

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 515989829 327 AEAHSALAQLYFREGKWPQAQSHFETALKVRSSVSDYAFLADALEKQNLNKAAHEVSRKALTL 389
Cdd:COG3071  258 PDLLLALGRLCLRNQLWGKAREYLEAALALRPSAEAYAELARLLEQLGDPEEAAEHYRKALAL 320
PRK10747 PRK10747
putative protoheme IX biogenesis protein; Provisional
 1-389 1.73e-86

putative protoheme IX biogenesis protein; Provisional


Pssm-ID: 182695 [Multi-domain]  Cd Length: 398  Bit Score: 267.73  E-value: 1.73e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829   1 MIRLIFLFVVLGAGLFVGTQFSGQQGYVLISIANTTIEMSVTTLVIFIVAALAGLFGLEYLVKKVLYTGFTTWNWFSVRK 80
Cdd:PRK10747   1 MLKVLLLFVLLIAGIVVGPMIAGHQGYVLIQTDNYNIETSVTGLAIILILAMVVLFAIEWLLRRIFRTGARTRGWFVGRK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829  81 MRRSRRYTNEGIIKLLEGDWKGAEKKVTRWASHHDMPLLCYLVASEAADGQGDKAKRDHYLALAAE-QENAYLAVELTRS 159
Cdd:PRK10747  81 RRRARKQTEQALLKLAEGDYQQVEKLMTRNADHAEQPVVNYLLAAEAAQQRGDEARANQHLERAAElADNDQLPVEITRV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829 160 KQLVREGEFAQAFDSLQSLKGRYPNNPIVLNLLKTTYLELKLWQPLIDLLPTLNKQALISPEDAEQMHQRAQCGLLADVA 239
Cdd:PRK10747 161 RIQLARNENHAARHGVDKLLEVAPRHPEVLRLAEQAYIRTGAWSSLLDILPSMAKAHVGDEEHRAMLEQQAWIGLMDQAM 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829 240 GQQGSEGLIKHWNTLPRKVKQDPHLVACFAKQLISRKaDHE-ALTVIKEALKKSPSPELYALLPQLNLGDVHPVVVMLEQ 318
Cdd:PRK10747 241 ADQGSEGLKRWWKNQSRKTRHQVALQVAMAEHLIECD-DHDtAQQIILDGLKRQYDERLVLLIPRLKTNNPEQLEKVLRQ 319

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515989829 319 NVKNDSQNAEAHSALAQLYFREGKWPQAQSHFETALKVRSSVSDYAFLADALEKQNLNKAAHEVSRKALTL 389
Cdd:PRK10747 320 QIKQHGDTPLLWSTLGQLLMKHGEWQEASLAFRAALKQRPDAYDYAWLADALDRLHKPEEAAAMRRDGLML 390
HemY_N pfam07219
HemY protein N-terminus; This family represents the N-terminus (approximately 150 residues) of ...
 29-132 2.69e-26

HemY protein N-terminus; This family represents the N-terminus (approximately 150 residues) of bacterial HemY porphyrin biosynthesis proteins. This is a membrane protein involved in a late step of protoheme IX synthesis.


Pssm-ID: 429353 [Multi-domain]  Cd Length: 104  Bit Score: 101.44  E-value: 2.69e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829   29 LISIANTTIEMSVTTLVIFIVAALAGLFGLEYLVKKVLYTGFTTWNWFSVRKMRRSRRYTNEGIIKLLEGDWKGAEKKVT 108
Cdd:pfam07219   1 LIVWGGYRIETSLWVAVLLLVLLFVLLYLLLRLLRLLLRLPGRVRRWRRRRRRRKARKALSEGLIALAEGDWAQAEKLAA 80

                          90       100
                  ....*....|....*....|....
gi 515989829  109 RWASHHDMPLLCYLVASEAADGQG 132
Cdd:pfam07219  81 KAAKLLDAPLLNYLLAARAAQLQG 104
HemYx COG3898
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to HemY-type ...
 1-388 2.89e-16

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to HemY-type protoporphyrinogen oxidase) [Function unknown];


Pssm-ID: 443105 [Multi-domain]  Cd Length: 468  Bit Score: 79.94  E-value: 2.89e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829   1 MIRLIFLFVVLGAGLFVGTQFSGQQGYVLISIANTTIEMSVTTLVIFIVAALAGLFGLEYLVKKVLYTGFTTWNWFSVRK 80
Cdd:COG3898    1 MIRILLFLALVAALALGAAWLADRPGTVSITWLGYEIETSLLVAAIALLVLAAAVWLLWRLLRFLLGSPTALSRYFRRRR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829  81 MRRSRRYTNEGIIKLLEGDWKGAEKKVTRWASHHDMPLLCYLVASEAADGQGDKAK-RDHYLALAAEQENAYLAV-ELTR 158
Cdd:COG3898   81 RRKGYQALSRGLIAVAAGDGRLARRKAAKAERLLDRPPLTLLLEAQAAQLAGDREAaRRAFEAMLEDPETRFLGLrGLMV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829 159 SKQlvREGEFAQAFDSLQ---SLKgryPNNPIVLNLLkttyLELKL----WQPLIDLLPTLNKQALISPEDAEqmHQRAq 231
Cdd:COG3898  161 EAL--RRGDTEAALALAEealALA---PKLPWAQDAL----LELQAaagdWDGALATLDAALKAGLLDKDVAR--RRRA- 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829 232 cgLLA-----DVAGQQGSEGLikhwnTLPRK-VKQDPHLV--ACFAKQLISRKADH-EALTVIKEALKKSPSPELYALLP 302
Cdd:COG3898  229 --VLLtararELEEGDPDEAR-----ELAIEaLKLAPDLVpaAVLAARLLIAQGKLrKAAKVLEKAWRAQPHPDLAAAYA 301

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829 303 QLNLGDVhPVVVM--LEQNVKNDSQNAEAHSALAQLYFREGKWPQAQSHFETALKVRSSVSDYAFLADALEKQNLNKA-A 379
Cdd:COG3898  302 ELRPGDS-ALDRLkrAETLAALNPDHPESRLALAEAALAAGDFGEARRALGPLLEERPTARVCLLMAEIERGEHGDDGrV 380


                 ....*....
gi 515989829 380 HEVSRKALT 388
Cdd:COG3898  381 REWLARALR 389
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 128-387 5.57e-13

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 68.60  E-value: 5.57e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829 128 ADGQGDKAkRDHYL-ALAAEQENAYLAVELTRSkqLVREGEFAQAFDSLQSLKGRYPNNPIVLNLLKTTYLELKLWQPLI 206
Cdd:COG2956   20 LNGQPDKA-IDLLEeALELDPETVEAHLALGNL--YRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAE 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829 207 DLLptlnKQALISPEDAEQMHQRaqcglLADVAGQQG-SEGLIKHWNTLPRKVKQDPHLVACFAKQLISRKADHEALTVI 285
Cdd:COG2956   97 ELL----EKLLELDPDDAEALRL-----LAEIYEQEGdWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEAL 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829 286 KEALKKSP-SPELYALLPQLNL--GDVHPVVVMLEQNVKNDSQNAEAHSALAQLYFREGKWPQAQSHFETALKVRSSVSD 362
Cdd:COG2956  168 EKALKLDPdCARALLLLAELYLeqGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDL 247

                        250       260
                 ....*....|....*....|....*
gi 515989829 363 YAFLADALEKQNLNKAAHEVSRKAL 387
Cdd:COG2956  248 LLALADLLERKEGLEAALALLERQL 272
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 269-389 2.41e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 55.20  E-value: 2.41e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829 269 AKQLISRKADHEALTVIKEALKKSP-SPELYALLPQ--LNLGDVHPVVVMLEQNVKNDSQNAEAHSALAQLYFREGKWPQ 345
Cdd:COG4783   11 AQALLLAGDYDEAEALLEKALELDPdNPEAFALLGEilLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDE 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 515989829 346 AQSHFETALKVR-SSVSDYAFLADALEKQNLNKAAHEVSRKALTL 389
Cdd:COG4783   91 ALALLEKALKLDpEHPEAYLRLARAYRALGRPDEAIAALEKALEL 135
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 130-355 3.51e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 54.35  E-value: 3.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829 130 GQGDKAKRDHYLALAAEQENAYLAVELTRSkqLVREGEFAQAFDSLQSLKGRYPNNPIVLNLLKTTYLELKLWQPLIDll 209
Cdd:COG2956   56 GEYDRAIRIHQKLLERDPDRAEALLELAQD--YLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIE-- 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829 210 pTLNKQALISPEDAEqmhqrAQCgLLADVAGQQGS-EGLIKHWNTLprkVKQDPHLVACF---AKQLISRKADHEALTVI 285
Cdd:COG2956  132 -VLERLLKLGPENAH-----AYC-ELAELYLEQGDyDEAIEALEKA---LKLDPDCARALlllAELYLEQGDYEEAIAAL 201

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 515989829 286 KEALKKSP-SPELYALLPQL--NLGDVHPVVVMLEQNVKNDSQNAeAHSALAQLYFREGKWPQAQSHFETALK 355
Cdd:COG2956  202 ERALEQDPdYLPALPRLAELyeKLGDPEEALELLRKALELDPSDD-LLLALADLLERKEGLEAALALLERQLR 273
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 221-355 1.29e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 47.49  E-value: 1.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829 221 EDAEQMHQRAQCGLLADvagqqGSEGLIKHWNTLPRKVKQDPHLVACFAKQLISRKADHEALTVIKEALKKSP-SPELYA 299
Cdd:COG4783    2 ACAEALYALAQALLLAG-----DYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPdEPEARL 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 515989829 300 LLPQL--NLGDVHPVVVMLEQNVKNDSQNAEAHSALAQLYFREGKWPQAQSHFETALK 355
Cdd:COG4783   77 NLGLAllKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALE 134
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 109-381 1.55e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 49.99  E-value: 1.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829 109 RWASHHDMPLLCYLVASEA-ADGQGDKAKRDHYLALAAEQENAYLAVELTRSKQLVREGEFAQAFDSLQSLKGRYPNNPI 187
Cdd:COG3914   34 AAALAAALGLALLLLAALAeAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAE 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829 188 VLNLLKTTYLELKLWQPLIDLLptlnKQAL-ISPEDAEQMHQRAQCglladvagqqgseglikhwntlprkvkqdphlva 266
Cdd:COG3914  114 ALFNLGNLLLALGRLEEALAAL----RRALaLNPDFAEAYLNLGEA---------------------------------- 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829 267 cfakqLISRKADHEALTVIKEALKKSPS-PELYALLPQL--NLGDVHPVVVMLEQNVKNDSQNAEAHSALAQLYFREGKW 343
Cdd:COG3914  156 -----LRRLGRLEEAIAALRRALELDPDnAEALNNLGNAlqDLGRLEEAIAAYRRALELDPDNADAHSNLLFALRQACDW 230

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 515989829 344 PQAQSHFETALKVR---SSVSDYAFLADALEKQNLNKAAHE 381
Cdd:COG3914  231 EVYDRFEELLAALArgpSELSPFALLYLPDDDPAELLALAR 271
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 130-355 1.69e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 50.08  E-value: 1.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829  130 GQGDKAKRDHYLALAAEQENAYLAVELTRSKQLVREGEFAQAFDSLQSLKGRYPNNPIVLNLLKTTYL--------ELKL 201
Cdd:TIGR02917 409 SQGDPSEAIADLETAAQLDPELGRADLLLILSYLRSGQFDKALAAAKKLEKKQPDNASLHNLLGAIYLgkgdlakaREAF 488

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829  202 WQPLI---DLLPTLNKQALI--SPEDAEQMHQRAQCGL------------LADVAGQQGSEGLIKHW-NTLPRKVKQDPH 263
Cdd:TIGR02917 489 EKALSiepDFFPAAANLARIdiQEGNPDDAIQRFEKVLtidpknlrailaLAGLYLRTGNEEEAVAWlEKAAELNPQEIE 568

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829  264 LVACFAKQLISRKADHEALTVIKEALKKSP-SPELYALL--PQLNLGDVHPVVVMLEQNVKNDSQNAEAHSALAQLYFRE 340
Cdd:TIGR02917 569 PALALAQYYLGKGQLKKALAILNEAADAAPdSPEAWLMLgrAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVM 648

                         250
                  ....*....|....*
gi 515989829  341 GKWPQAQSHFETALK 355
Cdd:TIGR02917 649 KNYAKAITSLKRALE 663
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 280-372 1.75e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 46.92  E-value: 1.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829 280 EALTVIKEALKKSP-SPELYALLPQL--NLGDVHPVVVMLEQNVKNDSQNAEAHSALAQLYFREGKWPQAQSHFETALKV 356
Cdd:COG4235   35 EALAAYEKALRLDPdNADALLDLAEAllAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLAL 114

                         90
                 ....*....|....*.
gi 515989829 357 RSSVSDYAFLADALEK 372
Cdd:COG4235  115 LPADAPARLLEASIAE 130
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 316-389 1.85e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 46.92  E-value: 1.85e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 515989829 316 LEQNVKNDSQNAEAHSALAQLYFREGKWPQAQSHFETALKVRSSVSDYAF-LADALEKQNLNKAAHEVSRKALTL 389
Cdd:COG4235    6 LRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLdLAEALLAAGDTEEAEELLERALAL 80
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 304-393 7.41e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 45.18  E-value: 7.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829 304 LNLGDVHPVVVMLEQNVKNDSQNAEAHSALAQLYFREGKWPQAQSHFETALKVRSSVSD-YAFLADALEKQNLNKAAHEV 382
Cdd:COG4783   15 LLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEaRLNLGLALLKAGDYDEALAL 94

                         90
                 ....*....|.
gi 515989829 383 SRKALTLIQSH 393
Cdd:COG4783   95 LEKALKLDPEH 105
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 116-355 1.12e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 47.39  E-value: 1.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829  116 MPLLCYLVASEAADGQGDKAkRDHYLALAAEQENAYLAVELTRSKQLvREGEFAQAFDSLQSLKGRYPNNPIVLNLLKTT 195
Cdd:TIGR02917 295 LPALLLAGASEYQLGNLEQA-YQYLNQILKYAPNSHQARRLLASIQL-RLGRVDEAIATLSPALGLDPDDPAALSLLGEA 372

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829  196 YLELKLWQPLIDLlptLNKQALISPEDAEQMHQRAQCGLladvaGQQGSEGLIKHWNTLPRKVKQDPHLVACFAKQLISR 275
Cdd:TIGR02917 373 YLALGDFEKAAEY---LAKATELDPENAAARTQLGISKL-----SQGDPSEAIADLETAAQLDPELGRADLLLILSYLRS 444

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829  276 KADHEALTVIKEALKKSP-SPELYALLPQ--LNLGDVHPVVVMLEQNVKNDSQNAEAHSALAQLYFREGKWPQAQSHFET 352
Cdd:TIGR02917 445 GQFDKALAAAKKLEKKQPdNASLHNLLGAiyLGKGDLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNPDDAIQRFEK 524


                  ...
gi 515989829  353 ALK 355
Cdd:TIGR02917 525 VLT 527
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 114-355 3.24e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 46.23  E-value: 3.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829  114 HDMPLLCYLVASEAADGQGDKAKRdhYLALAAEQENAYLAVELTRSKQLVREGEFAQAFDSLQSLKGRYPNNPIVLNLLK 193
Cdd:TIGR02917 531 KNLRAILALAGLYLRTGNEEEAVA--WLEKAAELNPQEIEPALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLG 608

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829  194 TTYLELKlwqPLIDLLPTLNKQALISPEDAEQMHqraqcgLLADV-AGQQGSEGLIKhwnTLPRKVKQDPHLV------- 265
Cdd:TIGR02917 609 RAQLAAG---DLNKAVSSFKKLLALQPDSALALL------LLADAyAVMKNYAKAIT---SLKRALELKPDNTeaqigla 676

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829  266 ----------------ACFAKQLISRKADHE--------------ALTVIKEALKKSPSPELYALL--PQLNLGDVHPVV 313
Cdd:TIGR02917 677 qlllaakrtesakkiaKSLQKQHPKAALGFElegdlylrqkdypaAIQAYRKALKRAPSSQNAIKLhrALLASGNTAEAV 756

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 515989829  314 VMLEQNVKNDSQNAEAHSALAQLYFREGKWPQAQSHFETALK 355
Cdd:TIGR02917 757 KTLEAWLKTHPNDAVLRTALAELYLAQKDYDKAIKHYQTVVK 798
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 304-389 4.83e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 43.41  E-value: 4.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829 304 LNLGDVHPVVVMLEQNVKNDSQNAEAHSALAQLYFREGKWPQAQSHFETALKVRSSVSD-YAFLADALEKQNLNKAAHEV 382
Cdd:COG5010   65 NKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNaYSNLAALLLSLGQDDEAKAA 144


                 ....*..
gi 515989829 383 SRKALTL 389
Cdd:COG5010  145 LQRALGT 151
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
304-389 6.75e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 43.84  E-value: 6.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829 304 LNLGDVHPVVVMLEQNVKNDSQNAEAHSALAQLYFREGKWPQAQSHFETALKVRSSVSD-YAFLADALEKQNLNKAAHEV 382
Cdd:COG0457   19 RRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEaLNNLGLALQALGRYEEALED 98


                 ....*..
gi 515989829 383 SRKALTL 389
Cdd:COG0457   99 YDKALEL 105
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 118-379 8.06e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 44.69  E-value: 8.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829  118 LLCYLVASEAADGQGDKAKRDHYLALAAEQENAYLAVELTRSKqlVREGEFAQAFDSLQSLKGRYPNNPIVLNLLKttyl 197
Cdd:TIGR02917 127 LLALRGLAYLGLGQLELAQKSYEQALAIDPRSLYAKLGLAQLA--LAENRFDEARALIDEVLTADPGNVDALLLKG---- 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829  198 elklwqpliDLLPTLNK--QALISPEDAEQMHQRAQCGLLADVA---GQQGSEGLIKHWNTLPRKVKQdpHLVACFAKQL 272
Cdd:TIGR02917 201 ---------DLLLSLGNieLALAAYRKAIALRPNNIAVLLALATiliEAGEFEEAEKHADALLKKAPN--SPLAHYLKAL 269

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829  273 IS-RKADHE-ALTVIKEALKKSPS---PELYALLPQLNLGDVHPVVVMLEQNVKNDSQNAEAHSALAQLYFREGKWPQAQ 347
Cdd:TIGR02917 270 VDfQKKNYEdARETLQDALKSAPEylpALLLAGASEYQLGNLEQAYQYLNQILKYAPNSHQARRLLASIQLRLGRVDEAI 349

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 515989829  348 SHFETALkvRSSVSDYAFLADA----LEKQNLNKAA 379
Cdd:TIGR02917 350 ATLSPAL--GLDPDDPAALSLLgeayLALGDFEKAA 383
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
303-389 1.76e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 40.15  E-value: 1.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829 303 QLNLGDVHPVVVMLEQNVKNDSQNAEAHSALAQLYFREGKWPQAQShFETALKVRSSVSD-YAFLADALEKQNLNKAAHE 381
Cdd:COG3063    2 YLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEaLLNLAELLLELGDYDEALA 80


                 ....*...
gi 515989829 382 VSRKALTL 389
Cdd:COG3063   81 YLERALEL 88
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 93-378 4.90e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.38  E-value: 4.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829   93 IKLLEGDWKGAEKKV----TRWASHHDMPLLCYLVASEAADGQGDKAKRDHYLALAAEQENAYLAveltRSKQLVREGEF 168
Cdd:TIGR02917 168 LALAENRFDEARALIdevlTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLA----LATILIEAGEF 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829  169 AQAFDSLQSLKGRYPNNPivlnllKTTYLelklwQPLIDLLPTLNKQALISPEDAEQMHQRAQCGLLadVAG----QQGS 244
Cdd:TIGR02917 244 EEAEKHADALLKKAPNSP------LAHYL-----KALVDFQKKNYEDARETLQDALKSAPEYLPALL--LAGaseyQLGN 310

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829  245 EGLIKHWntLPRKVKQDPHLVACF----AKQLISRKADhEALTVIKEALKKSP-SPELYALLPQ--LNLGDVHPVVVMLE 317
Cdd:TIGR02917 311 LEQAYQY--LNQILKYAPNSHQARrllaSIQLRLGRVD-EAIATLSPALGLDPdDPAALSLLGEayLALGDFEKAAEYLA 387

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 515989829  318 QNVKNDSQNAEAHSALAQLYFREGKWPQAQSHFETALKVRS--SVSDYAFLADALEKQNLNKA 378
Cdd:TIGR02917 388 KATELDPENAAARTQLGISKLSQGDPSEAIADLETAAQLDPelGRADLLLILSYLRSGQFDKA 450
TPR_12 pfam13424
Tetratricopeptide repeat;
327-392 9.20e-04

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 37.75  E-value: 9.20e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 515989829  327 AEAHSALAQLYFREGKWPQAQSHFETALKVRSSVSD---------YAFLADALEKQNLNKAAHEVSRKALTLIQS 392
Cdd:pfam13424   3 ATALNNLAAVLRRLGRYDEALELLEKALEIARRLLGpdhpltattLLNLGRLYLELGRYEEALELLERALALAEK 77
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 93-209 9.91e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.48  E-value: 9.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829  93 IKLLEGDWKGAEKKVTRWASHHDMPLLCYLVASEAADGQGDKAKRDHYLALAAEQENAYLAVELTRSKQLVREGEFAQAF 172
Cdd:COG2956  119 IYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAI 198

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 515989829 173 DSLQSLKGRYPNNPIVLNLLKTTYLELKLWQPLIDLL 209
Cdd:COG2956  199 AALERALEQDPDYLPALPRLAELYEKLGDPEEALELL 235
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
323-389 1.03e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 40.38  E-value: 1.03e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 515989829 323 DSQNAEAHSALAQLYFREGKWPQAQSHFETALKVRSSVSD-YAFLADALEKQNLNKAAHEVSRKALTL 389
Cdd:COG0457    4 DPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEaLYNLGLAYLRLGRYEEALADYEQALEL 71
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
280-387 1.09e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 40.38  E-value: 1.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829 280 EALTVIKEALKKSP-SPELYALLPQL--NLGDVHPVVVMLEQNVKNDSQNAEAHSALAQLYFREGKWPQAQSHFETALKV 356
Cdd:COG0457   60 EALADYEQALELDPdDAEALNNLGLAlqALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALEL 139

                         90       100       110
                 ....*....|....*....|....*....|..
gi 515989829 357 RSSVSD-YAFLADALEKQNLNKAAHEVSRKAL 387
Cdd:COG0457  140 DPDDADaLYNLGIALEKLGRYEEALELLEKLE 171
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
280-359 1.60e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.46  E-value: 1.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515989829 280 EALTVIKEALKKSPS-PELYALLPQL--NLGDvHPVVVMLEQNVKNDSQNAEAHSALAQLYFREGKWPQAQSHFETALKV 356
Cdd:COG3063   10 EAEEYYEKALELDPDnADALNNLGLLllEQGR-YDEAIALEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALEL 88


                 ...
gi 515989829 357 RSS 359
Cdd:COG3063   89 DPS 91
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 327-355 3.90e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 34.81  E-value: 3.90e-03
                          10        20
                  ....*....|....*....|....*....
gi 515989829  327 AEAHSALAQLYFREGKWPQAQSHFETALK 355
Cdd:pfam07719   1 AEALYNLGLAYYKLGDYEEALEAYEKALE 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH