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Conserved domains on  [gi|515953131|ref|WP_017383714|]
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MULTISPECIES: class I SAM-dependent methyltransferase [Enterobacter]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10549394)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; similar to Saccharomyces cerevisiae tRNA (carboxymethyluridine(34)-5-O)-methyltransferase

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0032259|GO:0008757|GO:0008168|GO:1904047
PubMed:  12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 77-125 6.11e-13

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


:

Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 62.68  E-value: 6.11e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 515953131   77 VKADPLHLPFAEKSIDACLLAHTLPWCSDPHRLLREADRVLIDDGWLIL 125
Cdd:pfam08241  46 VVGDAEDLPFPDNSFDLVLSSEVLHHVEDPERALREIARVLKPGGILII 94
 
Name Accession Description Interval E-value
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 77-125 6.11e-13

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 62.68  E-value: 6.11e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 515953131   77 VKADPLHLPFAEKSIDACLLAHTLPWCSDPHRLLREADRVLIDDGWLIL 125
Cdd:pfam08241  46 VVGDAEDLPFPDNSFDLVLSSEVLHHVEDPERALREIARVLKPGGILII 94
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 77-139 7.95e-12

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 61.16  E-value: 7.95e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 515953131  77 VKADPLHLPFAEKSIDACLLAHTLPWCSDPHRLLREADRVLIDDGWLILSGFNPLSLMGLRKL 139
Cdd:COG2226   74 VVGDAEDLPFPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEEL 136
PRK08317 PRK08317
hypothetical protein; Provisional
 71-126 2.28e-04

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 41.08  E-value: 2.28e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 515953131  71 NGSPVQ-VKADPLHLPFAEKSIDACLLAHTLPWCSDPHRLLREADRVLIDDGWLILS 126
Cdd:PRK08317  67 LGPNVEfVRGDADGLPFPDGSFDAVRSDRVLQHLEDPARALAEIARVLRPGGRVVVL 123
 
Name Accession Description Interval E-value
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 77-125 6.11e-13

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 62.68  E-value: 6.11e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 515953131   77 VKADPLHLPFAEKSIDACLLAHTLPWCSDPHRLLREADRVLIDDGWLIL 125
Cdd:pfam08241  46 VVGDAEDLPFPDNSFDLVLSSEVLHHVEDPERALREIARVLKPGGILII 94
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 77-139 7.95e-12

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 61.16  E-value: 7.95e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 515953131  77 VKADPLHLPFAEKSIDACLLAHTLPWCSDPHRLLREADRVLIDDGWLILSGFNPLSLMGLRKL 139
Cdd:COG2226   74 VVGDAEDLPFPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEEL 136
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 54-129 4.56e-06

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 44.62  E-value: 4.56e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515953131  54 EINTESCAISHQVSVSLNGSPVQvkADPLHLPFAEKSIDACLLAHTLPWCSDPHRLLREADRVLIDDGWLILSGFN 129
Cdd:COG2227   53 DISPEALEIARERAAELNVDFVQ--GDLEDLPLEDGSFDLVICSEVLEHLPDPAALLRELARLLKPGGLLLLSTPN 126
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 36-117 6.98e-05

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 40.62  E-value: 6.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515953131   36 WLAKMYGFHLlkIGnlsAEINTESCAISHQvSVSLNGSPVQ-VKADPLHLPFAEKSIDACLLAHTLPWCSDP--HRLLRE 112
Cdd:pfam13649  14 ALARRGGARV--TG---VDLSPEMLERARE-RAAEAGLNVEfVQGDAEDLPFPDGSFDLVVSSGVLHHLPDPdlEAALRE 87


                  ....*
gi 515953131  113 ADRVL 117
Cdd:pfam13649  88 IARVL 92
PRK08317 PRK08317
hypothetical protein; Provisional
 71-126 2.28e-04

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 41.08  E-value: 2.28e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 515953131  71 NGSPVQ-VKADPLHLPFAEKSIDACLLAHTLPWCSDPHRLLREADRVLIDDGWLILS 126
Cdd:PRK08317  67 LGPNVEfVRGDADGLPFPDGSFDAVRSDRVLQHLEDPARALAEIARVLRPGGRVVVL 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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